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370 results on '"Koh, Tse-Hsien"'

51. Risk factors and outcomes associated with the isolation of polymyxin B and carbapenem-resistant Enterobacteriaceae spp.: A case–control study

Author

Teo, Jocelyn Qi-Min, primary, Chang, Cassandra Wee-Ting, additional, Leck, Hui, additional, Tang, Cheng-Yee, additional, Lee, Shannon Jing-Yi, additional, Cai, Yiying, additional, Ong, Rick Twee-Hee, additional, Koh, Tse-Hsien, additional, Tan, Thuan-Tong, additional, and Kwa, Andrea Lay-Hoon, additional

Published
2019
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53. Streptococcus iniae discitis in Singapore

Author

Koh, Tse Hsien, Kurup, Asok, and Chen, John

Abstract

To the Editor: Streptococcus iniae is a well-recognized fish pathogen that can cause meningoencephalitis in tilapia and trout (1) and necrotizing myositis in red drum (2). We describe the first [...]

Published
2004

54. CTX-M and plasmid-mediated AmpC-producing Enterobacteriaceae, Singapore

Author

Koh, Tse Hsien, Yeng Wang, Grace Chee, Sng, Li-Hwei, Yi, Zhao, and Koh, Tse Yuen

Subjects
Enzymes
Abstract

To the Editor: In gram-negative bacteria, [beta]-lactamases are an important cause of antimicrobial resistance. In the 1990s, several new [beta]-lactamases, including CTX-M type and plasmid-mediated AmpC [beta]-lactamases, emerged. CTX-M extended [...]

Published
2004

55. Genotypes and virulence in serotype K2 Klebsiella pneumoniae from liver abscess and non-infectious carriers in Hong Kong, Singapore and Taiwan

Author

Lin, Jung-Chung, Koh, Tse Hsien, Lee, Nelson, Fung, Chang-Phone, Chang, Feng-Yee, Tsai, Yu-Kuo, Ip, Margaret, and Siu, L Kristopher

Subjects
Health
Abstract

In Klebsiella pneumoniae liver abscess (KP-LA), K. pneumonia e K2 is the most frequently isolated serotype after K1, but this serotype has been much less studied. In the present study, the molecular types sequences type (MLST) of serotype K2 isolates from three different regions in Asia were identified and the virulence of these isolates was investigated. Eight different MLSTs were found among 26 isolates (ST 65, 66, 86, 373, 374, 375, 380, and 434). There were two major MLST groups, ST-65-like (42%) and ST86-like (46%). No isolates contained allS while all isolates contained rmpA. The prevalence of aerobactin gene and kfu were 25/26 (96%) and 3/26 (11.5%) respectively. Although liver abscess isolates were generally more resistant (11/15 isolates) to serum killing, there was no specific distribution of serum killing resistant or susceptible ST types between stool carriage and liver abscess isolates. Neutrophil phagocytosis showed that the liver abscess and carriage isolates varied in their susceptibility to phagocytosis. Strains with resistance to both neutrophil phagocytosis and serum killing were generally hypervirulent with lethality at LD.sub.50 < 10.sup.3 colony forming units by intraperitoneal injection. In conclusion, Anti-phagocytosis and resistance to serum killing are two parameters that most predict hyperviurlence in serotype K2 isolates. Unlike serotype K1 KP-LA that mainly belong to ST-23, ST-65-like and -86-like are the two major MLST types among serotype K2 isolates from Singapore, Hong Kong and Taiwan. Keywords: Liver abscess, Klebsiella pneumoniae, MLST, Author(s): Jung-Chung Lin[sup.1] , Tse Hsien Koh[sup.2] , Nelson Lee[sup.3] , Chang-Phone Fung[sup.4] , Feng-Yee Chang[sup.1] , Yu-Kuo Tsai[sup.5] , Margaret Ip[sup.6] and L Kristopher Siu[sup.1,5,7] Introduction Klebsiella pneumoniae liver [...]

Published
2014
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58. Population genomics of hypervirulent Klebsiella pneumoniae clonal-group 23 reveals early emergence and rapid global dissemination

Author

Lam, Margaret M. C., primary, Wyres, Kelly L., additional, Duchêne, Sebastian, additional, Wick, Ryan R., additional, Judd, Louise M., additional, Gan, Yunn-Hwen, additional, Hoh, Chu-Han, additional, Archuleta, Sophia, additional, Molton, James S., additional, Kalimuddin, Shirin, additional, Koh, Tse Hsien, additional, Passet, Virginie, additional, Brisse, Sylvain, additional, and Holt, Kathryn E., additional

Published
2018
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61. Nod2 is required for the early innate immune clearance of Acinetobacter baumannii from the lungs

Author

Kale, Sandeep D., primary, Dikshit, Neha, additional, Kumar, Pankaj, additional, Balamuralidhar, Vanniarajan, additional, Khameneh, Hanif Javanmard, additional, Bin Abdul Malik, Najib, additional, Koh, Tse Hsien, additional, Tan, Gladys Gek Yen, additional, Tan, Thuan Tong, additional, Mortellaro, Alessandra, additional, and Sukumaran, Bindu, additional

Published
2017
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62. Population genomics of hypervirulentKlebsiella pneumoniaeclonal group 23 reveals early emergence and rapid global dissemination

Author

Lam, Margaret MC, primary, Wyres, Kelly L, additional, Duchêne, Sebastian, additional, Wick, Ryan R, additional, Judd, Louise M, additional, Gan, Yunn-Hwen, additional, Hoh, Chu-Han, additional, Achuleta, Sophia, additional, Molton, James S, additional, Kalimuddin, Shirin, additional, Koh, Tse Hsien, additional, Passet, Virginie, additional, Brisse, Sylvain, additional, and Holt, Kathryn E, additional

Published
2017
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65. Clinical and Molecular Epidemiology of Carbapenem-Resistant Enterobacteriaceae Among Adult Inpatients in Singapore

Author

Marimuthu, Kalisvar, primary, Venkatachalam, Indumathi, additional, Khong, Wei Xin, additional, Koh, Tse Hsien, additional, Cherng, Benjamin Pei Zhi, additional, Van La, My, additional, De, Partha Pratim, additional, Krishnan, Prabha Unny, additional, Tan, Thean Yen, additional, Choon, Raymond Fong Kok, additional, Pada, Surinder Kaur, additional, Lam, Choong Weng, additional, Ooi, Say Tat, additional, Deepak, Rama Narayana, additional, Smitasin, Nares, additional, Tan, Eng Lee, additional, Lee, Jia Jun, additional, Kurup, Asok, additional, Young, Barnaby, additional, Sim, Nancy Tee Wen, additional, Thoon, Koh Cheng, additional, Fisher, Dale, additional, Ling, Moi Lin, additional, Peng, Brenda Ang Sze, additional, Teo, Yik-Ying, additional, Hsu, Li Yang, additional, Lin, Raymond Tzer Pin, additional, Ong, Rick Twee-Hee, additional, Teo, Jeanette, additional, and Ng, Oon Tek, additional

Published
2017
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66. ST3268: a geographically widespread primate MRSA clone

Author

Hsu, Li-Yang, primary, Holden, Matthew T. G., additional, Koh, Tse Hsien, additional, Pettigrew, Kerry A., additional, Cao, Delphine, additional, Hon, Pei Yun, additional, Sergio, Darvi M., additional, Pena, Edgar, additional, and Ogden, Bryan E., additional

Published
2017
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69. Evaluating Polymyxin B-Based Combinations against Carbapenem-Resistant Escherichia coli in Time-Kill Studies and in a Hollow-Fiber Infection Model

Author

Cai, Yiying, primary, Lim, Tze-Peng, additional, Teo, Jocelyn Qi-Min, additional, Sasikala, Suranthran, additional, Chan, Eric Chun Yong, additional, Hong, Yan Jun, additional, Lee, Winnie, additional, Tan, Thean Yen, additional, Tan, Thuan Tong, additional, Koh, Tse Hsien, additional, Hsu, Li Yang, additional, and Kwa, Andrea L., additional

Published
2017
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70. EMRSA-15 Bacteremia is not Associated with a Worse Outcome Compared with Bacteremia Caused by Multidrug-Resistant MRSA

Author

Hsu, Li-Yang, Loomba-Chlebicka, Nidhi, Koh, Tse-Hsien, Kang, Mei-Ling, Tan, Ban-Hock, and Tambyah, Paul Ananth

Subjects
Staphylococcus aureus, methicillin resistance, bacteremia, bacterial infections and mycoses, outcomes, mortality, Article
Abstract

EMRSA-15 (ST22-MRSA-IV) is rapidly replacing the endemic ST239 health care-associated methicillin-resistant Staphylococcus aureus clone in Singapore. A one-year single-centre cohort study of inpatients with MRSA bacteremia was performed to determine if bacteremia caused by EMRSA-15 was associated with worse outcomes compared to bacteremia caused by the endemic ST239 strain. Strains were identified by antibiotypes, and subsequent validation was performed on a selected sample of MRSA strains via pulsed-field gel electrophoresis and staphylococcal chromosome cassette mec typing. Two hundred and twenty-eight patients with MRSA bacteremia were studied; Seventy-three were infected with EMRSA-15. EMRSA-15 and ST239-infected patients were similar regarding gender, frequencies of most co-morbidities, and risk factors for adverse outcomes. Similar numbers of EMRSA-15-infected and ST239-infected patients died (24.7% vs 27.1%, P=0.70) or developed complicated infections (41.1% vs 40.0%, P=0.88). After multivariate analysis, EMRSA-15 as a cause of bacteremia was not significantly associated with either death or development of complicated infections, although inappropriate therapy (5.45-fold, P

Published
2007

74. Comparative genomic analysis of Streptococcus dysgalactiaesubspecies dysgalactiae, an occasional cause of zoonotic infection

Author

Koh, Tse Hsien, Binte Abdul Rahman, Nurdyana, and Sessions, October Michael

Abstract

Streptococcus dysgalactiaecomprise two subspecies. Typically, S. dysgalactiaesubspecies equisimilis(SDSE) are large colony β-haemolytic Group C and Group G streptococci that cause pharyngitis, skin and soft tissue infections in humans. On the other hand, S. dysgalactiaesubspecies dysgalactiae(SDSD) are classically described as α-haemolytic Group C streptococci that are animal pathogens. We compared the genome sequences of five S. dysgalactiaeisolated from four cases of bacteraemia in women with breast cancer, and one from fish meat. One human isolate was SDSE, all other isolates were SDSD. Zoonotic SDSD infection may be under-recognised because of lack of patient and clinician awareness, and failure to distinguish SDSD from SDSE in the routine lab. The possibility of zoonotic SDSD should be suspected in patients with bacteraemia and ascending cellulitis of the upper limb with a history of handling raw fish and meat.

Published
2020
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75. In Vitro Activity of Polymyxin B in Combination with Various Antibiotics against Extensively Drug-Resistant Enterobacter cloacae with Decreased Susceptibility to Polymyxin B

Author

Cai, Yiying, primary, Lim, Tze-Peng, additional, Teo, Jocelyn, additional, Sasikala, Suranthran, additional, Lee, Winnie, additional, Hong, Yanjun, additional, Chan, Eric Chun Yong, additional, Tan, Thean Yen, additional, Tan, Thuan-Tong, additional, Koh, Tse Hsien, additional, Hsu, Li Yang, additional, and Kwa, Andrea L., additional

Published
2016
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76. Tracking inter-institutional spread of NDM and identification of a novel NDM-positive plasmid, pSg1-NDM, using next-generation sequencing approaches

Author

Khong, Wei Xin, primary, Marimuthu, Kalisvar, additional, Teo, Jeanette, additional, Ding, Yichen, additional, Xia, Eryu, additional, Lee, Jia Jun, additional, Ong, Rick Twee-Hee, additional, Venkatachalam, Indumathi, additional, Cherng, Benjamin, additional, Pada, Surinder Kaur, additional, Choong, Weng Lam, additional, Smitasin, Nares, additional, Ooi, Say Tat, additional, Deepak, Rama Narayana, additional, Kurup, Asok, additional, Fong, Raymond, additional, Van La, My, additional, Tan, Thean Yen, additional, Koh, Tse Hsien, additional, Lin, Raymond Tzer Pin, additional, Tan, Eng Lee, additional, Krishnan, Prabha Unny, additional, Singh, Siddharth, additional, Pitout, Johann D., additional, Teo, Yik-Ying, additional, Yang, Liang, additional, and Ng, Oon Tek, additional

Published
2016
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77. From Bench-Top to Bedside: A Prospective In Vitro Antibiotic Combination Testing (iACT) Service to Guide the Selection of Rationally Optimized Antimicrobial Combinations against Extensively Drug Resistant (XDR) Gram Negative Bacteria (GNB)

Author

Cai, Yiying, primary, Chua, Nathalie Grace, additional, Lim, Tze-Peng, additional, Teo, Jocelyn Qi-Min, additional, Lee, Winnie, additional, Kurup, Asok, additional, Koh, Tse-Hsien, additional, Tan, Thuan-Tong, additional, and Kwa, Andrea L., additional

Published
2016
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82. In Vitro Activities of Ceftazidime-Avibactam, Aztreonam-Avibactam, and a Panel of Older and Contemporary Antimicrobial Agents against Carbapenemase-Producing Gram-Negative Bacilli

Author

Vasoo, Shawn, primary, Cunningham, Scott A., additional, Cole, Nicolynn C., additional, Kohner, Peggy C., additional, Menon, Sanjay R., additional, Krause, Kevin M., additional, Harris, Kelly A., additional, De, Partha P., additional, Koh, Tse Hsien, additional, and Patel, Robin, additional

Published
2015
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86. In Vitro Pharmacodynamics of Various Antibiotics in Combination against Extensively Drug-Resistant Klebsiella pneumoniae

Author

Lim, Tze-Peng, primary, Cai, Yiying, additional, Hong, Yanjun, additional, Chan, Eric Chun Yong, additional, Suranthran, Sasikala, additional, Teo, Jocelyn Qi-Min, additional, Lee, Winnie Huiling, additional, Tan, Thean-Yen, additional, Hsu, Li-Yang, additional, Koh, Tse-Hsien, additional, Tan, Thuan-Tong, additional, and Kwa, Andrea Lay-Hoon, additional

Published
2015
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87. Evolutionary dynamics of methicillin-resistant Staphylococcus aureus within a healthcare system

Author

Hsu, Li-Yang, primary, Harris, Simon R, additional, Chlebowicz, Monika A, additional, Lindsay, Jodi A, additional, Koh, Tse-Hsien, additional, Krishnan, Prabha, additional, Tan, Thean-Yen, additional, Hon, Pei-Yun, additional, Grubb, Warren B, additional, Bentley, Stephen D, additional, Parkhill, Julian, additional, Peacock, Sharon J, additional, and Holden, Matthew TG, additional

Published
2015
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90. Community-associated methicillin-resistant Staphylococcus aureus, Singapore

Author

Hsu, Li-Yang, Tristan, Anne, Koh, Tse-Hsien, Bes, Michele, Etienne, Jerome, Kurup, Asok, Tan, Thuan-Tong, and Tan, Ban-Hock

Abstract

To the Editor: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging phenomenon that has been reported from almost every continent in the world (1-4). Such strains are usually characterized by [...]

Published
2005

91. Panton-Valentine leukocidin-positive Staphylococcus aureus, Singapore

Author

Hsu, Li-Yang, Koh, Tse-Hsien, Anantham, Devanand, Kurup, Asok, Chan, Kenneth Ping Wah, and Tan, Ban-Hock

Subjects
Pneumonia, Bacterial pneumonia
Abstract

To the Editor: Necrotizing community-acquired pneumonia attributable to Panton-Valentine leukocidin-producing strains of Staphylococcus aureus has been described as a distinct clinical syndrome with a high death rate in young, immunocompetent [...]

Published
2004

93. Changing molecular epidemiology and high rates of mupirocin resistance among meticillin-resistant Staphylococcus aureus in Singaporean hospitals

Author

Hon, Pei Yun, primary, Koh, Tse Hsien, additional, Tan, Thean Yen, additional, Krishnan, Prabha, additional, Leong, Janice Wai-Yeng, additional, Jureen, Roland, additional, Chan, Joey, additional, Tee, Nancy Wen-Sim, additional, Murugesh, Jagadeesan, additional, Chan, Kian Sing, additional, and Hsu, Li Yang, additional

Published
2014
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98. Arginine Catabolic Mobile Element in Methicillin-Resistant Staphylococcus aureus (MRSA) Clonal Group ST239-MRSA-III Isolates in Singapore: Implications for PCR-Based Screening Tests

Author

Hon, Pei Yun, primary, Chan, Kian Sing, additional, Holden, Matthew T., additional, Harris, Simon R., additional, Tan, Thean Yen, additional, Zu, Yan-Bing, additional, Krishnan, Prabha, additional, Oon, Lynette L., additional, Koh, Tse Hsien, additional, and Hsu, Li Yang, additional

Published
2013
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99. Emergence and global spread of epidemic healthcare-associated Clostridium difficile

Author

He, Miao, primary, Miyajima, Fabio, additional, Roberts, Paul, additional, Ellison, Louise, additional, Pickard, Derek J, additional, Martin, Melissa J, additional, Connor, Thomas R, additional, Harris, Simon R, additional, Fairley, Derek, additional, Bamford, Kathleen B, additional, D'Arc, Stephanie, additional, Brazier, Jon, additional, Brown, Derek, additional, Coia, John E, additional, Douce, Gill, additional, Gerding, Dale, additional, Kim, Hee Jung, additional, Koh, Tse Hsien, additional, Kato, Haru, additional, Senoh, Mitsutoshi, additional, Louie, Tom, additional, Michell, Stephen, additional, Butt, Emma, additional, Peacock, Sharon J, additional, Brown, Nick M, additional, Riley, Tom, additional, Songer, Glen, additional, Wilcox, Mark, additional, Pirmohamed, Munir, additional, Kuijper, Ed, additional, Hawkey, Peter, additional, Wren, Brendan W, additional, Dougan, Gordon, additional, Parkhill, Julian, additional, and Lawley, Trevor D, additional

Published
2012
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