922 results on '"Koenig, T."'
Search Results
52. Synaptic Molecular and Neurophysiological Markers Are Independent Predictors of Progression in Alzheimer's Disease
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Smailovic, U., Kåreholt, Ingemar, Koenig, T., Ashton, N. J., Winblad, B., Höglund, K., Nilsson, P., Zetterberg, H., Blennow, K., Jelic, V., Smailovic, U., Kåreholt, Ingemar, Koenig, T., Ashton, N. J., Winblad, B., Höglund, K., Nilsson, P., Zetterberg, H., Blennow, K., and Jelic, V.
- Abstract
Background: Cerebrospinal fluid (CSF) neurogranin and quantitative electroencephalography (qEEG) are potential molecular and functional markers of synaptic pathology in Alzheimer's disease (AD). Synaptic markers have emerged as candidate prognostic indicators of AD since synaptic degeneration was shown to be an early event and the best correlate of cognitive deficits in patients along the disease continuum. Objective: The present study investigated the association between CSF neurogranin and qEEG measures as well as their potential to predict clinical deterioration in mild cognitive impairment (MCI) patients. Methods: Patients diagnosed with MCI (n=99) underwent CSF conventional AD biomarkers and neurogranin analysis and resting-state EEG recordings. The study population was further stratified into stable (n=41) and progressive MCI (n=31), based on the progression to AD dementia during two years follow-up. qEEG analysis included computation of global field power and global field synchronization in four conventional frequency bands. Results: CSF neurogranin levels were associated with theta power and synchronization in the progressive MCI group. CSF neurogranin and qEEG measures were significant predictors of progression to AD dementia, independent of baseline amyloid status in MCI patients. A combination of CSF neurogranin with global EEG power in theta and global EEG synchronization in beta band exhibited the highest classification accuracy as compared to either of these markers alone. Conclusion: qEEG and CSF neurogranin are independent predictors of progression to AD dementia in MCI patients. Molecular and neurophysiological synaptic markers may have additive value in a multimodal diagnostic and prognostic approach to dementia.
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- 2021
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53. The hidden structure dependence of the chemical life of dislocations
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Zhou, X., primary, Mianroodi, J. R., additional, Kwiatkowski da Silva, A., additional, Koenig, T., additional, Thompson, G. B., additional, Shanthraj, P., additional, Ponge, D., additional, Gault, B., additional, Svendsen, B., additional, and Raabe, D., additional
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- 2021
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54. Investigation of electrophysiological markers to predict clinical and functional outcome of schizophrenia using sparse partial least square regression
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Giuliani, L., primary, Popovic, D., additional, Koutsouleris, N., additional, Giordano, G.M., additional, Koenig, T., additional, Mucci, A., additional, Vignapiano, A., additional, Altamura, M., additional, Bellomo, A., additional, Brugnoli, R., additional, Corrivetti, G., additional, Lorenzo, G. Di, additional, Girardi, P., additional, Monteleone, P., additional, Niolu, C., additional, Galderisi, S., additional, and Maj, M., additional
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- 2021
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55. Multivariate approach to identify electrophysiological markers for diagnosis and prognosis of schizophrenia
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Giuliani, L., primary, Koutsouleris, N., additional, Koenig, T., additional, Mucci, A., additional, Vignapiano, A., additional, Reuf, A., additional, Altamura, M., additional, Bellomo, A., additional, Brugnoli, R., additional, Corrivetti, G., additional, Lorenzo, G. Di, additional, Girardi, P., additional, Monteleone, P., additional, Galderisi, S., additional, and Maj, M., additional
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- 2021
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56. Plasticity in the adult language system: A longitudinal electrophysiological study on second language learning
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Stein, M., Dierks, T., Brandeis, D., Wirth, M., Strik, W., and Koenig, T.
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- 2006
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57. Dexamethasone depresses the expression of l-selectin but not the in vivo migration of bovine neutrophils into the uterus
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König, T., Schuberth, H.J., Leibold, W., and Zerbe, H.
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- 2006
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58. The Relationship Between Synovial Fluid and Cartilage Chondroitin Sulfate-846 Epitope in a Model of Experimentally Induced Osteoarthritis in Horses Treated Intravenously with Pentosan Polysulfate, Nʼacetyl Glucosamine and Sodium Hyaluranon.
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Koenig, T., Dart, A., McIlwraith, W., Bell, R., Perkins, N., Jeffcott, L., and Little, C.
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- 2012
59. P108Deficiency of cardiac cytidine monophospho-N-acetylneuraminic acid synthetase (CMAS) determines arrhythmias in the murine heart
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Hoch, M., Koenig, T., Gardiwal, A., Stapel, B., Erschow, S., Froese, A., Weinhold, B., Gerardy-Schahn, R., Klein, G., and Hilfiker-Kleiner, D.
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- 2012
60. A deviant EEG brain microstate in acute, neuroleptic-naive schizophrenics at rest
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Koenig, T., Lehmann, Dietrich, Merlo, Marco C. G., Kochi, Kieko, Hell, Daniel, and Koukkou, Martha
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- 1999
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61. Estimating the time needed for induction of anaesthesia and its importance in balancing anaesthetistsʼ and surgeonsʼ waiting times around the start of surgery
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Koenig, T., Neumann, C., Ocker, T., Kramer, S., Spies, C., and Schuster, M.
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- 2011
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62. P.779 Multivariate investigations of electrophysiological indices for the diagnosis and prognosis of schizophrenia
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Giuliani, L., primary, Koutsouleris, N., additional, Vignapiano, A., additional, Koenig, T., additional, Mucci, A., additional, Giordano, G.M., additional, Reuf, A., additional, Altamura, M., additional, Bellomo, A., additional, Brugnoli, R., additional, Corrivetti, G., additional, Lorenzo, G. Di, additional, Girardi, P., additional, Monteleone, P., additional, Niolu, C., additional, Galderisi, S., additional, and Maj, M., additional
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- 2020
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63. Disorganization and cognitive impairment in schizophrenia: new insights from electrophysiological findings
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Vignapiano, A., Koenig, T., Mucci, A., Giordano, G. M., Amodio, A., Altamura, M., Bellomo, A., Brugnoli, R., Corrivetti, G., Di Lorenzo, G., Girardi, P., Monteleone, P., Niolu, C., Galderisi, S., Maj, M., Piegari, G., Merlotti, E., Plescia, G. M., Montefusco, V., Gallo, O., Romano, P., Carnevale, R., La Montagna, M., Ferrentino, F., Siracusano, A., Comparelli, A., Corigliano, V., Cascino, G., Del Buono, G., Vignapiano, A., Koenig, T., Mucci, A., Giordano, G. M., Amodio, A., Altamura, M., Bellomo, A., Brugnoli, R., Corrivetti, G., Di Lorenzo, G., Girardi, P., Monteleone, P., Niolu, C., Galderisi, S., and Maj, M.
- Subjects
Adult ,Male ,medicine.medical_specialty ,alpha rhythm ,difficulty in abstract thinking ,disorganization dimension ,neurocognitive domains ,spectral power ,topographic analysis ,Alpha (ethology) ,Audiology ,Neuropsychological Tests ,050105 experimental psychology ,Correlation ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Cognition ,Physiology (medical) ,medicine ,Humans ,0501 psychology and cognitive sciences ,Cognitive Dysfunction ,610 Medicine & health ,Association (psychology) ,Problem Solving ,Positive and Negative Syndrome Scale ,General Neuroscience ,05 social sciences ,Brain ,Electroencephalography ,500 Science ,Middle Aged ,medicine.disease ,Brain Waves ,Electrophysiology ,Neuropsychology and Physiological Psychology ,Settore MED/25 ,Schizophrenia ,570 Life sciences ,biology ,Neurocognitive domain ,Female ,Schizophrenic Psychology ,Psychology ,Neurocognitive ,030217 neurology & neurosurgery - Abstract
In subjects with schizophrenia (SCZ), the disorganization dimension is a strong predictor of real-life functioning. "Conceptual disorganization" (P2), "Difficulty in abstract thinking" (N5) and "Poor attention" (G11) are core features of the disorganization factor, evaluated using the Positive and Negative Syndrome Scale. The heterogeneity of this dimension and its overlap with neurocognitive deficits are still debated. Within the multicenter study of the Italian Network for Research on Psychoses, we investigated electrophysiological and neurocognitive correlates of disorganization and its component items to assess the heterogeneity of this dimension and its possible overlap with neurocognitive deficits. Resting state EEG was recorded in 145 stabilized SCZ and 69 matched healthy controls (HC). Spectral amplitude was averaged in ten frequency bands. Neurocognitive domains were assessed by MATRICS Consensus Cognitive Battery (MCCB). RAndomization Graphical User software explored band spectral amplitude differences between groups and correlations with disorganization and MCCB scores in SCZ. Correlations between disorganization and MCCB scores were also investigated. Compared to HC, SCZ showed increased delta, theta, and beta 1 and decreased alpha 2 activity. A negative correlation between alpha 1 and disorganization was observed in SCZ. At the item level, only "N5" showed the same correlation. MCCB neurocognitive composite score was associated with disorganization, "P2" and "N5". Our findings suggest only a partial overlap between disorganization and neurocognitive impairment. The association of alpha 1 with the "N5" item suggests that some aspects of disorganization could be underpinned by the impairment of basic neurobiological functions that are only partially evaluated using MCCB.
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- 2019
64. Fallbericht: Individuelle selbsthaltende Gaumen-Obturator-Epithese zur Wiederherstellung des Gaumens nach Tumorresektion
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Koenig, T, additional, Pietsch, M, additional, and Schwab, B, additional
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- 2020
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65. Case report: Individual self-retaining palate-obturator epithesis to restore the palate after tumour resection
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Koenig, T, additional, Pietsch, M, additional, and Schwab, B, additional
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- 2020
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66. Bonding Energetics in Organometallic Compounds
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TOBIN J. MARKS, Tobin J. Marks, Peter B. Armentrout, Petra A. M. van Koppen, Michael T. Bowers, J. L. Beauchamp, David V. Dearden, Ben S. Freiser, David E. Richardson, Charles S. Christ, Paul Sharpe, Matthew F. Ryan, John R. Eyler, Dennis L. Lichtenberger, Ann S. Copenhaver, Jack Halpern, T. Koenig, T. W. Scott, Jame, Tobin J. Marks, M. Joan Comstock
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- 1990
67. Sparseness in Space Meets Sparseness in Time: EEG Sychronization is Associated with fMRI Resting State Networks
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Koenig, T, Jann, K, Kottlow, M, Boesch, C, Strik, W, and Dierks, T
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- 2009
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68. Decreased EEG synchronization in Alzheimer’s disease and mild cognitive impairment
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Koenig, T., Prichep, L., Dierks, T., Hubl, D., Wahlund, L.O., John, E.R., and Jelic, V.
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- 2005
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69. Prestimulus EEG microstates influence visual event-related potential microstates in field maps with 47 channels
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Kondakor, I., Lehmann, D., Michel, C. M., Brandeis, D., Kochi, K., and Koenig, T.
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- 1997
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70. Event-related potential P300 microstate topography during visual one- and two-dimensional tasks in chronic schizophrenics
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Kochi, K., Koenig, T., Strik, W. K., and Lehmann, D.
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- 1996
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71. Sex Differences in Semantic Processing: Event-Related Brain Potentials Distinguish between Lower and Higher Order Semantic Analysis during Word Reading
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Wirth, M., Horn, H., Koenig, T., Stein, M., Federspiel, A., Meier, B., Michel, C.M., and Strik, W.
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- 2007
72. Frequency domain source localization shows state-dependent diazepam effects in 47-channel EEG
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Michel, C. M., Pascual-Marqui, R. D., Strik, W. K., Koenig, T., and Lehmann, D.
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- 1995
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73. Quantitative detection of iodine in the stratosphere
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National Science Foundation (US), National Aeronautics and Space Administration (US), European Commission, Koenig, T. K. [0000-0002-3756-4315], Baidar, S. [0000-0002-9837-294X], Campuzano-Jost, Pedro [0000-0003-3930-010X], Cuevas, Carlos A. [0000-0002-9251-5460, Fernández, Rafael P. [0000-0002-4114-5500], Hall, S. R. [0000-0002-2060-7112], Kinnison, Douglas [0000-0002-3418-0834], Ullmann, K. [0000-0002-4724-9634], Saiz-Lopez, A. [0000-0002-0060-1581], Volkamer, Rainer [0000-0002-0899-1369], Koenig, T.K., Baidar, S., Campuzano-Jost, Pedro, Cuevas, Carlos A., Dix, B., Fernández, Rafael P., Guo, H., Hall, S.R., Kinnison, Douglas E., Nault, Benjamin A., Ullmann, K., Jiménez, José L., Saiz-Lopez, A., Volkamer, Rainer, National Science Foundation (US), National Aeronautics and Space Administration (US), European Commission, Koenig, T. K. [0000-0002-3756-4315], Baidar, S. [0000-0002-9837-294X], Campuzano-Jost, Pedro [0000-0003-3930-010X], Cuevas, Carlos A. [0000-0002-9251-5460, Fernández, Rafael P. [0000-0002-4114-5500], Hall, S. R. [0000-0002-2060-7112], Kinnison, Douglas [0000-0002-3418-0834], Ullmann, K. [0000-0002-4724-9634], Saiz-Lopez, A. [0000-0002-0060-1581], Volkamer, Rainer [0000-0002-0899-1369], Koenig, T.K., Baidar, S., Campuzano-Jost, Pedro, Cuevas, Carlos A., Dix, B., Fernández, Rafael P., Guo, H., Hall, S.R., Kinnison, Douglas E., Nault, Benjamin A., Ullmann, K., Jiménez, José L., Saiz-Lopez, A., and Volkamer, Rainer
- Abstract
Oceanic emissions of iodine destroy ozone, modify oxidative capacity, and can form new particles in the troposphere. However, the impact of iodine in the stratosphere is highly uncertain due to the lack of previous quantitative measurements. Here, we report quantitative measurements of iodine monoxide radicals and particulate iodine (Iy,part) from aircraft in the stratosphere. These measurements support that 0.77 ± 0.10 parts per trillion by volume (pptv) total inorganic iodine (Iy) is injected to the stratosphere. These high Iy amounts are indicative of active iodine recycling on ice in the upper troposphere (UT), support the upper end of recent Iy estimates (0 to 0.8 pptv) by the World Meteorological Organization, and are incompatible with zero stratospheric iodine injection. Gas-phase iodine (Iy,gas) in the UT (0.67 ± 0.09 pptv) converts to Iy,part sharply near the tropopause. In the stratosphere, IO radicals remain detectable (0.06 ± 0.03 pptv), indicating persistent Iy,part recycling back to Iy,gas as a result of active multiphase chemistry. At the observed levels, iodine is responsible for 32% of the halogen-induced ozone loss (bromine 40%, chlorine 28%), due primarily to previously unconsidered heterogeneous chemistry. Anthropogenic (pollution) ozone has increased iodine emissions since preindustrial times (ca. factor of 3 since 1950) and could be partly responsible for the continued decrease of ozone in the lower stratosphere. Increasing iodine emissions have implications for ozone radiative forcing and possibly new particle formation near the tropopause.
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- 2020
74. Cognitive response control in writerʼs cramp
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Berg, D., Herrmann, M. J., Müller, T. J., Strik, W. K., Aranda, D., Koenig, T., Naumann, M., and Fallgatter, A. J.
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- 2001
75. Chronic schizophrenics with positive symptomatology have shortened EEG microstate durations
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Strelets, V, Faber, P.L, Golikova, J, Novototsky-Vlasov, V, Koenig, T, Gianotti, L.R.R, Gruzelier, J.H, and Lehmann, D
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- 2003
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76. Visualisation of flow processes in packed beds with NMR imaging: determination of the local porosity, velocity vector and local dispersion coefficients
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Götz, J., Zick, K., Heinen, C., and König, T.
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- 2002
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77. Cage Pair Intermediates and Activation Parameters
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Koenig, T., primary, Scott, T. W., additional, and Franz, James A., additional
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- 1990
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78. Liraglutide and Renal Outcomes in Type 2 Diabetes
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Mann JFE, Ørsted DD, Brown-Frandsen K, Marso SP, Poulter NR, Rasmussen S, Tornøe K, Zinman B, Buse JB, LEADER Steering Committee and Investigators. Bergenstal R, Daniels G, Moses AC, Nauck M, Nissen S, Pocock S, Steinberg W, Stockner M, Kristensen P, Ravn LS, Zychma M, Flyvbjerg A, Ford I, Kloos RT, Schactman MJ, Sleight P, Swedberg K, Tenner SM, Akalın S, Arechavaleta R, Bain S, Babkowski MC, Benroubi M, Berard L, Comlekci A, Czupryniak L, Eliasson B, Eriksson M, Fonseca V, Franek E, Gross J, Hafidh K, Haluzik M, Hayes F, Huang YY, Jacob S, Kaddaha G, Khalil A, Kilhovd B, Laakso M, Leiter L, Lalic N, Ji L, Luedemann J, Mannucci E, Marre M, Masmiquel L, Mota M, Omar M, O’Shea D, Pan C, Petrie J, Pieber T, Pratley R, Raz I, Rea R, Rutten G, Satman I, Shestakova M, Simpson R, Smith D, Tack C, Tarnow L, Thomas N, Van Gaal L, Travert F, Vidal J, Warren M, Yoon KH, Tuttle RM, Sheerman SI, Hegedüs L, Baerwald H, Bergenstal M, Celik S, Dias C, Eder M, Fitzgibbons S, Irvhage L, Kloluckova J, Kriulianski R, McDuffie R, Moen S, Paster A, Saalfeld RM, Sankar K, Shehaj E, Swierzewska P, Tiktin M, Tovey S, Gibson CM, Chakrabarti AK, Dashe JF, Hinchey J, Leary MC, Pride Y, Wiviott S, Allen S, Mehr AP, Mutter WP, Parikh S, Ray S, Cheifetz A, Leffler D, Sheth S, Alexander E, Gaglia JL, Goessling W, Mitzner LD, Rosenberg C, Snow KJ, Wagner A, Piazza G, Abell S, Davis T, D'Emden M, Ding SA, Gilfillan C, Greenaway T, Gunawan F, Ho J, Jackson R, Kalra B, Lau SL, Lin J, MacIsaac R, Makepeace A, Malabu U, Marjason J, McCallum R, McLean M, Moin N, Petersons C, Price S, Roberts A, Roberts D, Sangla K, Stranks S, Tan Y, Thynne T, Walters J, Ward G, Wen W, Zhang J, Brix J, Feder A, Höbaus C, Höllerl F, Höller V, Kotter T, Kratz E, Krzizek EC, Leb-Stoeger U, Mader J, Mras N, Novak E, Obendorf F, Peric S, Pesau G, Prager R, Ribitsch A, Schnack C, Schernthaner G, Wascher T, Batens AH, Benhalima K, De Block C, Ernest P, Fouckova A, Jandrain B, Lapauw B, Letiexhe M, Mathieu C, Neven S, Peiffer F, Ruige J, Scheen A, Taes Y, Van Boxelaer I, Vandistel G, Van Durme Y, Verhaegen A, Alencar E, Alencar R, Almeida AC, Alves B, Alves E, Alves G, Alves J, Araujo L, Arruda V, Augusto GA, Baggentoss R, Balestrassi L, Barbosa M, Barcelos I, Belem L, de Bem A, Betti RT, Bona R, Bosco A, Branda J, Bronstein M, Bueno T, Bulcão T, Caiado F, Camazzola F, Cambréa MF, Campos S, Canani L, Carra MK, Caruso S, Carvalho N, Casillo A, Castro D, Cavalcanti T, Cavichioli V, Cercato C, Chacra A, Challela W, Charchar HS, Chaves C, Chrisman C, Correia-Deur J, da Costa A Jr, Costa M, Costi B, Coutinho P, Coutinho W, Cunha MR, Daher J Jr, Davini E, Democh D Jr, Eliaschewitz F, Esmanhoto Facin G, Farias F, Felício J, Fernandes V, Filho CS, Filho FF, Filho M, Fontan D, Fontenele AP, Forti A, Franco D, Freire K, Fusaro A, Genestreti P, Gerchman F, Godi A, Gomes KF, Gonçalves P, Gonçalves R, Griz L, Grossman M, Gurgel MH, Vasconcellos Haddad AW, Halpern A, Hissa M, Inuy A, Jaime J, Jonasson T, Jorge JC, Malucelli FJ, Kohara S, Kramer C, Lacerda C, Ladeira S, Lana J, Lastebasse F, Leitão A, Leite S, Lerário AC, Lima D, Lima M, Lippi V, Lunardi M, Machado E, Maia F, Maia J, Maia KP, Mañas N, Marchisotti F, Marinho C, Martins C, Figueiredo de Medeiros F, Melo A, Melo F, Mendonca E, Mendonça P, Filho RM, Miguel M, Miléo K, Miyahara M, Montenegro AP, Moraes A, Moreira A, Ítalo Mota J, Mothe FS, Murro A, Nakatani V, Napoli TF, Neto BG, Neto OQ, Niclewicz E, Ohe LN, Oliveira F, Oliveira M, Panarotto D, Parente E, Parolin S, Pechmann L, Costa da Penha P, Perlamagna L, Perotta B, Pimentel L, Pinto M, Poço C, Ponte C, Prazeres P, Quintao E, Raduan R, Rassi DT, Rassi N, Reck L, Montenegro R Jr, Ribeiro R, Rodovalho S, Silveira Rodrigues G, Rollin G, Rossi S, Sabino C, Sales AP, Salles J, Sampaio CR, Santana L, Sato V, da Silva Santos M, Santos NL, Santos R, Saraiva J, Sartori C, Sena R, Sevilha M, Sgarbi J, Silva D, D'albuquerque Silva L, Silva ME, Siqueira K, Soares S, Sobreira W, Sousa B, Souza AC, Souza B, Tambascia M, Tarantino R, Tenor F, Tomarchio M, Triches C, Tristão LJ, Valenti A, Vasques E, Vencio S, Vianna A, Munhoz Vidotto T, Vieira S, Villar H, Visconti G, Volaco A, Wajchenberg B, Zanatta L, Zimmerman L, Abbott EC, Abu-Bakare A, Advani A, Allison R, Bishara P, Bowering CK, Cheng A, Chouinard S, Clayton D, Conway J, D'Amours M, de Tugwell B, DeYoung P, D'Ignazio G, Dube F, Ekoe JM, Fagan S, Garceau C, Gottesman I, Hanna A, Harris S, Hramiak IM, Hurd C, Imran S, Josse R, Joyce C, Kaiser S, Khan F, Kirouac I, Kovacs C, Labonte I, Langlois WJ, Levac MF, Liutkus J, McDonald C, Milosevic V, Nyomba BL, Paul T, Raby K, Ransom T, Reichert SM, Retnakaran R, Rabasa-Lhoret R, Raff E, Shaikholeslami R, Sigalas J, Yip CE, Weisnagel SJ, Woo V, Bao Y, Cai X, Chen J, Chen K, Chen M, Chen X, Chen Y, Ji Y, Lei J, Li H, Liu P, Mu Y, Ren M, Ren Y, Shi Y, Wang D, Wang F, Wang J, Wang Y, Yan L, Yang G, Yang J, Yu X, Yuan G, Xu M, Zhao X, Zheng J, Zhou L, Anderlová K, Brožová J, Haluzík M, Hanušová V, Kosák M, Křížová J, Mráz M, Owen K, Rušavý Z, Tomešová J, Trachta P, Žourek M, Andersen PH, Boesgaard T, Christensen S, Gram J, Gregersen S, Henriksen JE, Hermansen K, Jakobsen PE, Jensen J, Krogsaa A, Larsen M, Lervang HH, Madsbad S, Mortensen L, Olesen T, Pietraszek A, Ridderstråle M, Safai N, Schioldan AG, Schmidt C, Snorgaard O, Stidsen J, Cederberg H, Haapamäki H, Hukkanen J, Jauhiainen R, Kujari ML, Lahtela J, Laine M, Mäkelä J, Miilunpohja M, Savolainen M, Taurio J, Vänttinen M, Creton C, Cosma NV, Dillinger J, Jacques JL, Guedj AM, Moulla M, Petit C, Ratsianoharana V, Richter D, Rodier M, Roussel R, Hinz A, Politz E, Esser M, Deuse U, Mittag D, Hagenow A, Jacob F, Jordan R, Gantke D, Venschott-Jordan U, Löhr C, Klausmann G, Eschenbrücher K, Karakas M, Jahrsdörfer B, Kunze MR, Wöhrle J, König W, Spielhagen H, Kilimnik A, Lüdemann HP, Lüdemann J, Mölle A, Mölle M, Müller J, Appelt S, Sauter A, Sauter J, Hartmann U, Löw A, Krötz F, Sohn HY, von Schacky C, Klauss V, Braun D, Segner A, Degtyareva E, Kreutzmann K, Paschmionka R, Hauck N, Sihal O, Busch AK, Maus O, Stübler P, Füllgraf-Horst S, Vietzke A, Müller C, Tosch-Sisting R, Lengsfeld B, Thaler J, Schaum T, Steindorf J, Steindorf S, König A, Reitschuster S, Schlott D, Clever HU, Witzel P, Kempe HP, Stemler L, Benis A, Diakoumopoulou E, Kazakos K, Kypraios N, Liatis S, Pagkalos E, Siami E, Tentolouris N, Alur VC, Agrawal M, Ali M, Asirvatham A, Asirvatham E, Bandgar TR, Balaji M, Bardoloi N, Baruah M, Bekur R, Bhansali A, Bhatia S, Bhonsley S, Bhuyan S, Borah B, Bright N, Ambrish C, Chaudhury T, Choudhury S, Chellan G, Das M, Dharmalingam M, Dutta P, Erugu A, Vinutha FP, Gunasekaran P, Das Gupta R, Iqbal A, Jagadish P, Jain S, Jebasingh H, John A, John M, Kalra S, Kasaragod P, Kesavadev J, Kumar H, Kumar P, Lakshmanan V, Lila AR, Mathew T, Miyen H, Mohan T, Motha A, Murthy C, Shivashankara N, Nanaiah A, Ommen T, Pani K, Pandey K, Paramesh S, Paramesh V, Pillai B, Prabhu M, Kalki RC, Ramachandran S, Ramu M, Rao Y, Reddy S, Saikia P, Saravu K, Selvam K, Sethi B, Shankar A, Sharma A, Shah N, Shankar P, Shetty R, Shivane V, Srivalli S, Thaseen 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Sutton T, Tabbah I, Talsania M, Tang R, Tapia J, Taylor K, Taylor-Hancher R, Teator R, Tekateka M, Temple B, Temple K, Teodori M, Tharp P, Thethi T, Theuma P, Thomas S, Thottan A, Thrasher J, Thrasher L, Tiemeyer M, Tinney I, Tobin T, Toma S, Tovar M, Townsend J, Trantow C, Traylor H, Trevino M, Troy M, Trumper D, Tryggestad J, Tucker C, Turner J, Turney R, Tuten C, Tyzack J, Ullo L, Underkofler C, Unger J, Urdanetta R, Valdivia V, Valenti S, Vanderheiden A, Vanderlinde-Wood M, Varma C, Vasquez E, Vazquez M, Vickery D, Villafuerte B, Villegas C, Vivar J, Vivekananthan K, Vo G, Vukojicic K, Wachter A, Wahl D, Waitmann J, Walker D, Walsh J, Walsh K, Walton A, Wang A, Wardell K, Watkins S, Watkinson J, Watts M, Watwe V, Weaver N, Weber R, Wedick C, Weeks D, Weeks L, Weindorff K, Weinstein R, Weiss S, Wenger K, Wentworth M, Werner A, West M, Whelan S, White B, White J, Whitmire M, Whittington R, Wical J, Wigley C, Wilkins F, Will K, Williams A, Wilson LE, Wince M, Wine S, Winkle P, Winner C, Wise J, Witte M, Wittenmyer J, Wood C, Wood R, Woodruff C, Worthington B, Wynn D, Wysham C, Xavier P, Yela S, Yenoby L, Young L, Younus N, Yourell V, Zaid M, Zubair I., Mann, Jfe, Ørsted, Dd, Brown-Frandsen, K, Marso, Sp, Poulter, Nr, Rasmussen, S, Tornøe, K, Zinman, B, Buse, Jb, Bergenstal R, LEADER Steering Committee and Investigators., Daniels, G, Moses, Ac, Nauck, M, Nissen, S, Pocock, S, Steinberg, W, Stockner, M, Kristensen, P, Ravn, L, Zychma, M, Flyvbjerg, A, Ford, I, Kloos, Rt, Schactman, Mj, Sleight, P, Swedberg, K, Tenner, Sm, Akalın, S, Arechavaleta, R, Bain, S, Babkowski, Mc, Benroubi, M, Berard, L, Comlekci, A, Czupryniak, L, Eliasson, B, Eriksson, M, Fonseca, V, Franek, E, Gross, J, Hafidh, K, Haluzik, M, Hayes, F, Huang, Yy, Jacob, S, Kaddaha, G, Khalil, A, Kilhovd, B, Laakso, M, Leiter, L, Lalic, N, Ji, L, Luedemann, J, Mannucci, E, Marre, M, Masmiquel, L, Mota, M, Omar, M, O’Shea, D, Pan, C, Petrie, J, Pieber, T, Pratley, R, Raz, I, Rea, R, Rutten, G, Satman, I, 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S, Pechmann, L, Costa da Penha, P, Perlamagna, L, Perotta, B, Pimentel, L, Pinto, M, Poço, C, Ponte, C, Prazeres, P, Quintao, E, Raduan, R, Rassi, Dt, Rassi, N, Reck, L, Montenegro, R Jr, Ribeiro, R, Rodovalho, S, Silveira Rodrigues, G, Rollin, G, Rossi, S, Sabino, C, Sales, Ap, Salles, J, Sampaio, Cr, Santana, L, Sato, V, da Silva Santos, M, Santos, Nl, Santos, R, Saraiva, J, Sartori, C, Sena, R, Sevilha, M, Sgarbi, J, Silva, D, D'albuquerque Silva, L, Silva, Me, Siqueira, K, Soares, S, Sobreira, W, Sousa, B, Souza, Ac, Souza, B, Tambascia, M, Tarantino, R, Tenor, F, Tomarchio, M, Triches, C, Tristão, Lj, Valenti, A, Vasques, E, Vencio, S, Vianna, A, Munhoz Vidotto, T, Vieira, S, Villar, H, Visconti, G, Volaco, A, Wajchenberg, B, Zanatta, L, Zimmerman, L, Abbott, Ec, Abu-Bakare, A, Advani, A, Allison, R, Bishara, P, Bowering, Ck, Cheng, A, Chouinard, S, Clayton, D, Conway, J, D'Amours, M, de Tugwell, B, Deyoung, P, D'Ignazio, G, Dube, F, Ekoe, Jm, Fagan, S, Garceau, C, Gottesman, I, 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T, Hagan, A, Hager, S, Haggag, A, Haggar, M, Hamilton, M, Hamlet, P, Hammond, J, Hansen, A, Harrell, W, Harris, E, Harris, K, Harris, M, Harrison, L, Hartman, I, Hatch, A, Hayes, D, Hayes, M, Heath, J, Heineman, R, Heinzman, A, Hendrick, M, Herbst, R, Hermayer, K, Hibbard, J, Hill, Wd, Hilliard, B, Hix, M, Hoch, B, Hollander, P, Holmes, Z, Horobetz, C, Horowitz, R, Hsieh, P, Hsieh, S, Htun, W, Huang, J, Huber, C, Hudson, T, Huizar, S, Hull, B, Hull, J, Hummer, K, Hundal, R, Hunt, G, Hunt, V, Hutchinson, P, Hwang, J, Iannamorelli, A, Iannuzzi, L, Ingram, M, Iram, N, Ismail-Beigi, F, Jabbour, S, Jackson, T, Jaen, L, Jain, V, Jannesari, R, Januski, V, Japa, U, Jarvis, K, Jayson, L, Jensen, R, Jester, D, Jocko, C, Johnson, C, Johnson, M, Johnston, K, Jones, D, Jones, J, Jordan, T, Juarez, M, Kaapuraala, A, Kain, A, Kaiser, V, Kamradt, K, Karatoprakli, P, Karegar, M, Karounos, C, Karounos, D, Karunaratne, H, Katalenich, B, Katic, K, Katz, M, Kaur, G, Kawa, A, Keib, C, Keider, G, Kem, D, Kennedy, R, Kenney, B, Kereiakes, D, Ketana, M, Kettinger, L, Khaira, A, Khan, A, Khan, K, Khan, M, Khoo, T, Khrlobyan, N, Kilgore, J, Kim, G, Kimble, S, Kinsley, M, Kitchen, T, Klick, M, Kniffen, W, Knight, R, Kodzwa, D, Koenig, T, Komarovskiy, K, Kong, Y, Koontz, D, Krishnasamy, S, Krueger, E, Kuechenmeister, L, Kuehl, A, Kuettel, K, Kugler, D, Kulow, T, Kupriyanchik, I, Kuruvanka, T, Kushner, D, Kwon, E, Kwon, S, Kyle, M, Labryer, L, Labuda, J, Lafave, J, Laguerre, J, Laliberte, A, Lane, J, Langel, C, Lann, D, Largay, J, Latif, K, Latus, T, Lawrence, J, Ledger, G, Lee, Fg, Lee, E, Leffert, J, Leinung, M, Lenhard, Mj, Lentino, J, Leon, J, Leonard, M, Letassy, N, Leuck, K, Levin, P, Levinson, D, Lewis, M, Light, T, Lim, J, Lindamood, R, Lingvay, I, Lipps, J, Lisa, A, Livingston, Y, Llamas, L, Loesch, R, Long, T, Looby, R, Lopez, C, Lorenz, T, Lovre, D, Lu, P, Lucas, K, Luevano, G, Luidens, M, Luna, B, Luttrell, L, Lyons, T, Macadams, M, Mack, D, Mack, M, Madden, M, Madder, R, Madireddy, S, Mae, L, Mahakala, A, Maheshwari, H, Malbari, H, Maldonado, N, Mallitz, M, Mandviwala, M, Mann, K, Mardahay, M, Marino, J, Marney, A, Marshall, L, Martin, A, Martin, E, Martinez, G, Martinez-Miss, S, Marx, P, Massara, L, Mastoor, M, Matfin, G, Maturu, A, Maurides, P, May, M, Mayfield, R, Maynard, B, Mazza, A, Mccann, K, Mccoy, J, Mccoy, T, Mccullen, Mk, Mcdaniel, C, Mcdaniel, Am, Mcdermott, M, Mcdonald, A, Mcmasters, B, Mcmurray, C, Medlin, T, Meinel, M, Mendez, I, Menefee, J, Meredith, M, Merriweather, M, Mersey, J, Messino, C, Meyer, S, Meyers, L, Michael, D, Midyett, C, Miklius, A, Milford, E, Miller, B, Miller, H, Milligan, M, Minor, A, Miranda-Palma, B, Mirarchi, N, Mittadodla, S, Mittle, J, Moffat, A, Mohaupt, S, Mohiuddin, K, Mokshagundam, S, Monaco, S, Monsaert, R, Montano-Pereira, C, Montgomery, A, Moody, K, Moon, M, Moore, D, Moore, L, Morawski, E, Moreau, C, Morin, D, Moscoa, C, Motzkin, C, Mueller, R, Munoz, C, Munoz, M, Myneni, A, Naderi, B, Nagireddy, P, Naidu, J, Naidu, R, Naik, S, Naimark, R, Nardicchi, M, Ndukwu, I, Neller, C, Netten-Foster, L, Neumiller, J, New, T, Newman, S, Newton, T, Nguyen, B, Nicol, B, Nicol, P, Ninivaggi, L, Niswender, K, Norman, L, Noworatzky, G, Nyenwe, E, O'Brien, H, O'Connell, T, Oden, W, Odugbesan, A, Oliver, M, Oliver, T, Olmeda, C, O'Neil, C, Oremus, R, Ortega, T, Ortiz-Santos, S, Osborn, T, Padmanabhan, S, Papacostea, O, Park, I, Parker, A, Parker, K, Parker, R, Patel, C, Patel, M, Patel, R, Patino, M, Patterson, S, Paulson, K, Paz, A, Pemba, R, Pepe, C, Perez, J, Perez, T, Perry, D, Phillips, B, Phillips, J, Pickett, A, Pinson, M, Pitzer, R, Poduri, M, Poehls, J, Poteat, T, Powell, L, Prasad, S, Prevost, J, Price, E, Priest, D, Prieto, L, Purewal, T, Purighalla, R, Purighalla, U, Quadrel, M, Qureshi, A, Radhamma, R, Rafla, E, Rajab, H, Ramalingam, R, Ramirez, A, J, Ramirez, Ramirez, K, Ramirez, M, Randall, M, Rangaraj, U, Rao, V, Rasmussen, P, Rasouli, N, Ray, A, Reed, J, Rems, L, Renaud, K, Reno, M, Resnick, M, Reusch, J, Reynolds, L, Rhoton, K, Rhudy, J, Ricci, C, Rice, L, Richardson, A, Richardson, L, Rickard, H, Rickels, M, Riff, D, Rightenour, N, Risser, J, Rizvi, A, Robertson, J, Robinson, A, Robinson, R, Rockwell, M, Rodriguez, Jp, Rodriguez, M, Rojas, M, Rojas, W, Rooker-Morris, L, Root, C, Rose, M, Rosenberg, R, Rosenstock, J, Roth, M, Ruby, R, Sachson, R, Sack, P, Sadler, Rk, Sahai, S, J, Salazar, Salgam, M, Samal, A, Samson, A, Sanagorski, R, Sanchez, A, Sandberg, J, Sanderson, M, Sandoval, J, Santiago, E, Sapp, T, Saunders, J, Schill, J, Schott, C, Schreiman, R, Schu, D, Schuh, K, Schutta, M, Schwartz, J, Schweppe, L, Scofield, H, Scribner, A, Seal, J, Sealock, J, Seaton, B, Sedlak-Hanslik, T, Seekins, K, Segal, M, Seggelke, S, Semenza, S, Sentman, P, Serra, M, Seshadri, P, Sevilla, E, Shah, S, Shaheen, K, Shanik, M, Shaw, J, Sheets, M, Shellabarger, C, Sher, J, Shippey, J, Shivaswamy, V, Shomali, M, Shore, D, Shroff, P, Siddiqui, T, Siegwald, A, Silver, R, Simmons, D, 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E, Vazquez, M, Vickery, D, Villafuerte, B, Villegas, C, Vivar, J, Vivekananthan, K, Vo, G, Vukojicic, K, Wachter, A, Wahl, D, Waitmann, J, Walker, D, Walsh, J, Walsh, K, Walton, A, Wang, A, Wardell, K, Watkins, S, Watkinson, J, Watts, M, Watwe, V, Weaver, N, Weber, R, Wedick, C, Weeks, D, Weeks, L, Weindorff, K, Weinstein, R, Weiss, S, Wenger, K, Wentworth, M, Werner, A, West, M, Whelan, S, White, B, White, J, Whitmire, M, Whittington, R, Wical, J, Wigley, C, Wilkins, F, Will, K, Williams, A, Wilson, Le, Wince, M, Wine, S, Winkle, P, Winner, C, Wise, J, Witte, M, Wittenmyer, J, Wood, C, Wood, R, Woodruff, C, Worthington, B, Wynn, D, Wysham, C, Xavier, P, Yela, S, Yenoby, L, Young, L, Younus, N, Yourell, V, Zaid, M, Zubair, I., Mann J.F.E., Orsted D.D., Brown-Frandsen K., Marso S.P., Poulter N.R., Rasmussen S., Tornoe K., Zinman B., Buse J.B., and Buscemi S.
- Subjects
Male ,Settore MED/09 - Medicina Interna ,Acute Kidney Injury ,Aged ,Albuminuria ,Creatinine ,Diabetes Mellitus, Type 2 ,Diabetic Nephropathies ,Double-Blind Method ,Female ,Follow-Up Studies ,Glomerular Filtration Rate ,Glucagon-Like Peptide 1 ,Humans ,Hypoglycemic Agents ,Intention to Treat Analysis ,Kidney Failure, Chronic ,Liraglutide ,Middle Aged ,Type 2 diabetes ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,GLOMERULAR-FILTRATION-RATE ,KIDNEY-FUNCTION ,DISEASE ,law.invention ,Kidney Failure ,chemistry.chemical_compound ,0302 clinical medicine ,Randomized controlled trial ,law ,Medicine ,Settore MED/49 - Scienze Tecniche Dietetiche Applicate ,Chronic ,RISK ,Kidney ,Acute kidney injury ,11 Medical And Health Sciences ,General Medicine ,medicine.anatomical_structure ,TRIAL ,liraglutide, randomized controlled trial, type 2 diabetes, renal outcomes ,Life Sciences & Biomedicine ,Type 2 ,medicine.drug ,medicine.medical_specialty ,Renal function ,030209 endocrinology & metabolism ,CARDIOVASCULAR OUTCOMES ,Follow-Up Studie ,03 medical and health sciences ,Medicine, General & Internal ,General & Internal Medicine ,Diabetes mellitus ,Internal medicine ,Diabetes Mellitus ,Intensive care medicine ,Science & Technology ,business.industry ,MORTALITY ,medicine.disease ,INTENSIVE GLUCOSE CONTROL ,INDIVIDUALS ,chemistry ,Diabetic Nephropathie ,LEADER Steering Committee and Investigators ,business - Abstract
BACKGROUND: In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2 diabetes and high cardiovascular risk who were receiving usual care, we found that liraglutide resulted in lower risks of the primary end point (nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes) and death. However, the long-term effects of liraglutide on renal outcomes in patients with type 2 diabetes are unknown. METHODS: We report the prespecified secondary renal outcomes of that randomized, controlled trial in which patients were assigned to receive liraglutide or placebo. The secondary renal outcome was a composite of new-onset persistent macroalbuminuria, persistent doubling of the serum creatinine level, end-stage renal disease, or death due to renal disease. The risk of renal outcomes was determined with the use of time-to-event analyses with an intention-to-treat approach. Changes in the estimated glomerular filtration rate and albuminuria were also analyzed. RESULTS: A total of 9340 patients underwent randomization, and the median follow-up of the patients was 3.84 years. The renal outcome occurred in fewer participants in the liraglutide group than in the placebo group (268 of 4668 patients vs. 337 of 4672; hazard ratio, 0.78; 95% confidence interval [CI], 0.67 to 0.92; P=0.003). This result was driven primarily by the new onset of persistent macroalbuminuria, which occurred in fewer participants in the liraglutide group than in the placebo group (161 vs. 215 patients; hazard ratio, 0.74; 95% CI, 0.60 to 0.91; P=0.004). The rates of renal adverse events were similar in the liraglutide group and the placebo group (15.1 events and 16.5 events per 1000 patient-years), including the rate of acute kidney injury (7.1 and 6.2 events per 1000 patient-years, respectively). CONCLUSIONS: This prespecified secondary analysis shows that, when added to usual care, liraglutide resulted in lower rates of the development and progression of diabetic kidney disease than placebo. (Funded by Novo Nordisk and the National Institutes of Health; LEADER ClinicalTrials.gov number, NCT01179048 .).
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- 2017
79. Mindfulness meditators show altered distributions of early and late neural activity markers of attention in a response inhibition task
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Di Russo, F, Bailey, NW, Freedman, G, Raj, K, Sullivan, CM, Rogasch, NC, Chung, SW, Hoy, KE, Chambers, R, Hassed, C, Van Dam, NT, Koenig, T, Fitzgerald, PB, Di Russo, F, Bailey, NW, Freedman, G, Raj, K, Sullivan, CM, Rogasch, NC, Chung, SW, Hoy, KE, Chambers, R, Hassed, C, Van Dam, NT, Koenig, T, and Fitzgerald, PB
- Abstract
Attention is vital for optimal behavioural performance in every-day life. Mindfulness meditation has been shown to enhance attention. However, the components of attention altered by meditation and the related neural activities are underexplored. In particular, the contributions of inhibitory processes and sustained attention are not well understood. To address these points, 34 meditators were compared to 28 age and gender matched controls during electroencephalography (EEG) recordings of neural activity during a Go/Nogo response inhibition task. This task generates a P3 event related potential, which is related to response inhibition processes in Nogo trials, and attention processes across both trial types. Compared with controls, meditators were more accurate at responding to Go and Nogo trials. Meditators showed a more frontally distributed P3 to both Go and Nogo trials, suggesting more frontal involvement in sustained attention rather than activity specific to response inhibition. Unexpectedly, meditators also showed increased positivity over the right parietal cortex prior to visual information reaching the occipital cortex (during the pre-C1 window). Both results were positively related to increased accuracy across both groups. The results suggest that meditators show altered engagement of neural regions related to attention, including both higher order processes generated by frontal regions, and sensory anticipation processes generated by poster regions. This activity may reflect an increased capacity to modulate a range of neural processes in order to meet task requirements. This increased capacity may underlie the improved attentional function observed in mindfulness meditators.
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- 2019
80. Topographic Time-Frequency Decomposition of the EEG
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Koenig, T., Marti-Lopez, F., and Valdes-Sosa, P.
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- 2001
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81. Decreased functional connectivity of EEG theta-frequency activity in first-episode, neuroleptic-naı̈ve patients with schizophrenia: preliminary results
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Koenig, T, Lehmann, D, Saito, N, Kuginuki, T, Kinoshita, T, and Koukkou, M
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- 2001
- Full Text
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82. Ground-based direct-sun DOAS and airborne MAX-DOAS measurements of the collision-induced oxygen complex, O2O2, absorption with significant pressure and temperature differences
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Spinei, E., Cede, A., Herman, J., Mount, G. H., Eloranta, E., Morley, B., Baidar, S., Dix, B., Ortega, I., Koenig, T., and Volkamer, R.
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lcsh:TA715-787 ,lcsh:Earthwork. Foundations ,lcsh:TA170-171 ,lcsh:Environmental engineering - Abstract
The collision-induced O2 complex, O2O2, is a very important trace gas for understanding remote sensing measurements of aerosols, cloud properties and atmospheric trace gases. Many ground-based multi-axis differential optical absorption spectroscopy (MAX-DOAS) measurements of the O2O2 optical depth require correction factors of 0.75 ± 0.1 to reproduce radiative transfer modeling (RTM) results for a nearly pure Rayleigh atmosphere. One of the potential causes of this discrepancy is uncertainty in laboratory-measured O2O2 absorption cross section temperature and pressure dependencies due to difficulties in replicating atmospheric conditions in the laboratory environment. This paper presents ground-based direct-sun (DS) and airborne multi-axis (AMAX) DOAS measurements of O2O2 absorption optical depths under actual atmospheric conditions in two wavelength regions (335–390 and 435–490 nm). DS irradiance measurements were made by the Washington State University research-grade Multi-Function Differential Spectroscopy Instrument instrument from 2007 to 2014 at seven sites with significant pressure (778 to 1013 hPa) and O2O2 profile-weighted temperature (247 to 275 K) differences. Aircraft MAX-DOAS measurements were conducted by the University of Colorado (CU) AMAX-DOAS instrument on 29 January 2012 over the Southern Hemispheric subtropical Pacific Ocean. Scattered solar radiance spectra were collected at altitudes between 9 and 13.2 km, with O2O2 profile-weighted temperatures of 231 to 244 K and nearly pure Rayleigh scattering conditions. Due to the well-defined DS air-mass factors during ground-based measurements and extensively characterized atmospheric conditions during the aircraft AMAX-DOAS measurements, O2O2 "pseudo" absorption cross sections, σ, are derived from the observed optical depths and estimated O2O2 column densities. Vertical O2O2 columns are calculated from the atmospheric sounding temperature, pressure and specific humidity profiles. Based on the ground-based atmospheric DS observations, there is no pressure dependence of the O2O2 σ within the measurement errors (3%). Two data sets are combined to derive the peak σ temperature dependence of the 360 and 477 nm dimer absorption bands from 231 to 275 K. DS and AMAX-derived peak σ ( O2O2) as a function of T can be described by a quadratic function at 360 nm and linear function at 477 nm with about 9% ± 2.5% per 44 K rate. Recent laboratory-measured O2O2 cross sections by Thalman and Volkamer (2013) agree with these "DOAS apparent" peak σ( O2O2) at 233, 253 and 273 K within 3%. Changes in the O2O2 spectral band shape at colder temperatures are observed for the first time in field data. Temperature effects on spectral band shapes can introduce errors in the retrieved O2O2 column abundances if a single room temperature σ( O2O2) is used in the DOAS analysis. Simultaneous fitting of σ( O2O2) at temperatures that bracket the ambient temperature range can reduce such errors. Our results show that laboratory-measured σ( O2O2) (Hermans, 2011, at 296 K and Thalman and Volkamer, 2013) are applicable for observations over a wide range of atmospheric conditions. Column densities derived using Hermans (2011) σ at 296 K require very small correction factors (0.94 ± 0.02 at 231 K and 0.99 ± 0.02 at 275 K) to reproduce theoretically calculated slant column densities for DS and AMAX-DOAS measurements. Simultaneous fitting of σ( O2O2) at 203 and 293 K further improved the results at UV and visible wavelengths for AMAX-DOAS.
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- 2015
83. BrO and Bry profiles over the Western Pacific : Relevance of Inorganic Bromine Sources and a Bry Minimum in the Aged Tropical Tropopause Layer
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Koenig, T. K., Volkamer, R., Baidar, S., Dix, B., Anderson, D. C., Salawitch, R. J., Wales, P. A., Cuevas, C. A., Fernandez, R. P., Saiz-Lopez, A., Evans, M. J., Sherwen, T., Jacob, D. J., Schmidt, J., Kinnison, D., Lamarque, J.-F., Apel, E. C., Bresch, J. C., Campos, T., Flocke, F. M., Honomichl, S. B., Hornbrook, R., Jensen, J. B., Lueb, R., Montzka, D. D., Pan, L. L., Reeves, J. M., Schauffler, S. M., Ullmann, K., Weinheimer, A. J., Atlas, E. L., Donets, V., Navarro, M. A., Riemer, D., Blake, N. J., Huey, L. G., Tanner, D. J., Hanisco, T. F., Wolfe, G. M., Wang, Siyuan, Chen, Dexien, and Hall, Samuel R.
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purl.org/becyt/ford/1 [https] ,BrO and Bry ,purl.org/becyt/ford/1.5 [https] ,CONTRAST ,Stratospheric Injection ,Meteorología y Ciencias Atmosféricas ,CIENCIAS NATURALES Y EXACTAS ,VSL Chemistry ,Ciencias de la Tierra y relacionadas con el Medio Ambiente - Abstract
We report measurements of bromine monoxide (BrO) and use an observationally constrained chemical box-model to infer total gas phase inorganic bromine (Bry) over the tropical Western Pacific Ocean (tWPO) during the CONTRAST field 40 campaign (January – February 2014). The median tropospheric BrO Vertical Column Density (VCD) over the tWPO was measured as 1.6×1013 molec. cm˗2, compared to model predictions of 0.4×1013 in CAM-Chem, 0.9×1013 in GEOS-Chem, and 2.1×1013 in GEOS-Chem with a sea-salt aerosol (SSA) bromine source. The observed BrO and inferred Bry profiles is found to be C-shaped in the troposphere, with local maxima in the marine boundary layer (MBL) and in the upper free troposphere. Neither global model fully captures this profile shape. Between 6 and 13.5 km, the inferred Bry is highly sensitive to 5 assumptions about the rate of heterogeneous bromine recycling (depends on the surface area of ice/aerosols), and the inclusion of a SSA bromine source. A local Bry maximum of 3.6 ppt (2.3-11.1 ppt, 95% CI) is observed between 9.5 and 13.5 km in air masses influenced by recent convective outflow. Unlike BrO, which increases from the convective TTL to the aged TTL, gas phase Bry decreases from the convective TTL to the aged TTL. Analysis of gas phase Bry against multiple tracers (CFC-11, H2O/O3 ratio, and θ) reveals a Bry minimum of 2.7 ppt (2.4-3.0 ppt, 95% CI) in the aged TTL, which is remarkably insensitive 10 to assumptions about heterogeneous chemistry. Bry increases to 6.3 ppt (5.9-6.7 ppt, 95% CI) in the stratospheric middleworld, and 6.9 ppt (6.7-7.1 ppt, 95% CI) in the stratospheric overworld. The local Bry minimum in the aged TTL is qualitatively (but not quantitatively) captured by CAM-chem, and suggests a more complex partitioning of gas phase and aerosol Bry species than previously recognized. Our data provide corroborating evidence that inorganic bromine sources (e.g., SSA derived gas phase Bry) are needed to explain the gas phase Bry budget in the TTL. They are also consistent with observations of significant 15 bromide in UTLS aerosols. The total Bry budget in the TTL is currently not closed, because of the lack of concurrent quantitative measurements of gas phase Bry species (i.e., BrO, HOBr, HBr, etc.) and aerosol bromide. These simultaneous measurements are needed 1) to quantify SSA derived Bry aloft, 2) to test Bry partitioning, and explain the gas phase Bry minimum in the aged TTL, 3) to constrain heterogeneous reaction rates of bromine, and 4) to account for all of the sources of Bry to the lower stratosphere. Fil: Koenig, Theodore K.. State University of Colorado at Boulder; Estados Unidos. Cooperative Institute for Research in Environmental Sciences; Estados Unidos Fil: Volkamer, Rainer. State University of Colorado at Boulder; Estados Unidos. Cooperative Institute for Research in Environmental Sciences; Estados Unidos Fil: Baidar, Sunil. Cooperative Institute for Research in Environmental Sciences; Estados Unidos. State University of Colorado at Boulder; Estados Unidos Fil: Dix, Barbara. State University of Colorado at Boulder; Estados Unidos Fil: Wang, Siyuan. State University of Colorado at Boulder; Estados Unidos. University of Michigan; Estados Unidos Fil: Anderson, Daniel C.. University of Maryland. Department of Atmospheric and Oceanic Science; Estados Unidos Fil: Salawitch, Ross J.. University of Maryland. Department of Atmospheric and Oceanic Science; Estados Unidos Fil: Wales, Pamela A.. University of Maryland. Department of Atmospheric and Oceanic Science; Estados Unidos Fil: Cuevas, Carlos A.. Consejo Superior de Investigaciones Científicas. Instituto de Química Física; España Fil: Fernandez, Rafael Pedro. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Universidad Tecnologica Nacional. Facultad Regional Mendoza. Secretaría de Ciencia, Tecnología y Postgrado; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina Fil: Saiz Lopez, Alfonso. Consejo Superior de Investigaciones Científicas. Instituto de Química Física; España Fil: Evans, Mathew J.. University of York; Reino Unido Fil: Sherwen, Tomás. University of York; Reino Unido Fil: Jacob, Daniel J.. Harvard University; Estados Unidos Fil: Schmidt, Johan. Universidad de Copenhagen; Dinamarca Fil: Kinnison, Douglas. National Center for Atmospheric Research; Estados Unidos Fil: Lamarque, Jean François. National Center for Atmospheric Research; Estados Unidos Fil: Apel, Eric C.. National Center for Atmospheric Research; Estados Unidos Fil: Bresch, James C.. National Center for Atmospheric Research; Estados Unidos Fil: Campos, Teresa. National Center for Atmospheric Research; Estados Unidos Fil: Flocke, Frank M.. National Center for Atmospheric Research; Estados Unidos Fil: Hall, Samuel R.. National Center for Atmospheric Research; Estados Unidos Fil: Honomichl, Shawn B.. National Center for Atmospheric Research; Estados Unidos Fil: Hornbrook, Rebecca. National Center for Atmospheric Research; Estados Unidos Fil: Jensen, Jorgen B.. National Center for Atmospheric Research; Estados Unidos Fil: Lueb, Richard. National Center for Atmospheric Research; Estados Unidos Fil: Montzka, Denise D.. National Center for Atmospheric Research; Estados Unidos Fil: Pan, Laura L.. National Center for Atmospheric Research; Estados Unidos Fil: Reeves, J. Michael. National Center for Atmospheric Research; Estados Unidos Fil: Schauffle, Sue M.. National Center for Atmospheric Research; Estados Unidos Fil: Ullmann, Kirk. National Center for Atmospheric Research; Estados Unidos Fil: Weinheimer, Andrew J.. National Center for Atmospheric Research; Estados Unidos Fil: Atlas, Elliot L.. University of Miami; Estados Unidos Fil: Donets, Valeria. University of Miami; Estados Unidos Fil: Maria A. Navarro. University of Miami; Estados Unidos Fil: Riemer, Daniel. University of Miami; Estados Unidos Fil: Blake, Nicola J.. University of California; Estados Unidos Fil: Chen, Dexien. School of Earth & Atmospheric Sciences; Estados Unidos Fil: Huey, L. Gregory. School of Earth & Atmospheric Sciences; Estados Unidos Fil: Tanner, David J.. School of Earth & Atmospheric Sciences; Estados Unidos Fil: Hanisco, Thomas F.. National Aeronautics and Space Administration; Estados Unidos Fil: Wolfe, Glenn M.. University of Maryland; Estados Unidos. National Aeronautics and Space Administration; Estados Unidos
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- 2017
84. Face-elicited ERPs and affective attitude: brain electric microstate and tomography analyses
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Pizzagalli, D., Lehmann, D., Koenig, T., Regard, M., and Pascual-Marqui, R.D.
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- 2000
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85. Synthesis and characterization of the layered sodium silicate ilerite
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Brenn, U, Ernst, H, Freude, D, Herrmann, R, Jähnig, R, Karge, H.G, Kärger, J, König, T, Mädler, B, Pingel, U.-T, Prochnow, D, and Schwieger, W
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- 2000
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- View/download PDF
86. Biometrische Verfahren zur Charakterisierung von Wachstumstypen und die Eigenarten der resultierenden Typologie
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Rempe, U. and Müller-König, T.
- Published
- 1975
87. Das Wachstum von Körperhöhe und Gewicht bei Knaben und Mädchen im Schulalter mit besonderer Berücksichtigung der sozialen Schichtung: Teil I: Methodische Grundlagen
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Müller-König, T.
- Published
- 1983
88. Das Wachstum von Körperhöhe und Gewicht bei Knaben und Mädchen im Schulalter mit besonderer Berücksichtigung der sozialen Schichtung: Teil II: Praktische Untersuchungen
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Müller-König, T.
- Published
- 1984
89. Antioxidant action of organic sulphites III. Antioxidative effect of esters of sulphurous acid in hydrocarbons and polypropylene
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Günther, A., König, T., Habicher, W.D., and Schwetlick, K.
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- 1999
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90. Cage-effects in organometallic radical chemistry. Fractional cage-recombination efficiency for photochemical caged-pair intermediates of Cp'2M2(CO)6 (M = Mo and W; Cp' = eta(super 5)-C5H4CH3)
- Author
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Covert, Katherine J., Askew, Edward F., Grunkemeier, John, Koenig, T., and Tyler, David R.
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Organometallic chemistry -- Research ,Radicals (Chemistry) -- Research ,Chemistry - Abstract
A new method for measuring photochemical cage-efficiency factors, F(sub cP), in photochemically generated radical cage pairs was reported. The method was applied to the measurement of F(sub cP) values for Cp'2M2(CO)6 caged pairs (M = Mo, W) in solvent systems of various viscosities. The results show that there is a significant cage effect even in common solvents. For example, F(sub cP) is expected to be about 0.3 for the Cp'2M2(CO)6 caged pair in cyclohexane at 23 degrees C.
- Published
- 1992
91. P802A novel scn5a loss-of-function mutation in a family with symptomatic brugada syndrome
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Mueller-Leisse, J, primary, Sanner, K, additional, Duncker, D, additional, Koenig, T, additional, Zormpas, C, additional, Leffler, A, additional, and Veltmann, C, additional
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- 2018
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92. P1241Transvenous pacing in fontan circulation - with and without a lead
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Mueller-Leisse, J, primary, Koenig, T, additional, Duncker, D, additional, Zormpas, C, additional, Westhoff-Bleck, M, additional, Horke, A, additional, and Veltmann, C, additional
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- 2018
- Full Text
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93. P928Compatibilies and incompatibilities - Systematic analysis of telemetry interferences between ICD families and LVAD models
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Duncker, D, primary, Michalski, R, additional, Mueller-Leisse, J, additional, Zormpas, C, additional, Koenig, T, additional, Schmitto, J D, additional, and Veltmann, C, additional
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- 2018
- Full Text
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94. P3.13-033 DNA Methylation of PTGER4 and SHOX2 in Liquid Biopsies Facilitates the Diagnosis of Lung Malignancy After Chest CT-Scan
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Schotten, L., primary, Darwiche, K., additional, Taube, C., additional, Aigner, C., additional, Welter, S., additional, Eisenmann, S., additional, Schlegel, A., additional, Koenig, T., additional, Hager, T., additional, Freitag, L., additional, He, K., additional, and Oezkan, F., additional
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- 2017
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95. Neurophysiological correlates of negative symptom domains in schizophrenia
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Giordano, G.M., primary, Koenig, T., additional, Mucci, A., additional, Vignapiano, A., additional, Amodio, A., additional, Di Lorenzo, G., additional, Niolu, C., additional, Altamura, M., additional, and Bellomo, A., additional
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- 2017
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96. Electrophysiological and neurocognitive correlates of the disorganization factor in schizophrenia
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Vignapiano, A., primary, Koenig, T., additional, Mucci, A., additional, Giordano, G.M., additional, Amodio, A., additional, Di Lorenzo, G., additional, Niolu, C., additional, Altamura, M., additional, Bellomo, A., additional, and Galderisi, S., additional
- Published
- 2017
- Full Text
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97. P1111Ventricular arrhythmias do not affect prognosis in patients with continuous-flow left ventricular assist devices
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Koenig, T., primary, Heimeshoff, J., additional, Duncker, D., additional, Schmitto, J., additional, and Veltmann, C., additional
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- 2017
- Full Text
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98. P1490Real-world experience of 355 consecutive patients with a wearable cardioverter/defibrillator - Single-centre analysis
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Duncker, D., primary, Koenig, T., additional, Michalski, R., additional, Mueller-Leisse, J., additional, Pfeffer, T., additional, Hohmann, S., additional, and Veltmann, C., additional
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- 2017
- Full Text
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99. Disorganization in Schizophrenia: A Resting EEG Study
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Vignapiano, A., primary, Koenig, T., additional, Mucci, A., additional, Giordano, G.-M., additional, Amodio, A., additional, Di Lorenzo, G., additional, Niolu, C., additional, Altamura, M., additional, Bellomo, A., additional, and Galderisi, S., additional
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- 2017
- Full Text
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100. Electrophysiological Correlates of Negative Symptom Domains in Schizophrenia
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Giordano, G.-M., primary, Koenig, T., additional, Mucci, A., additional, Vignapiano, A., additional, Amodio, A., additional, Di Lorenzo, G., additional, Niolu, C., additional, Altamura, M., additional, Bellomo, A., additional, and Galderisi, S., additional
- Published
- 2017
- Full Text
- View/download PDF
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