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Amaç: Bu çalışmada Hashimoto tiroiditinde (HT) interlökin-35 (IL-35) düzeylerinin ve tiroid fonksiyon testleri ile ilişkisinin incelenmesi amaçlandı.Gereç ve Yöntem: Çalışmaya 18-65 yaş arasında yeni HT tanısı almış (ötiroid, subklinik hipotiroidi ve aşikar hipotiroidi) 128 kişi ile bilinen herhangi bir hastalığı veya ilaç kullanımı olmayan 38 sağlık kontrolü dahil edildi.Bulgular: IL-35 düzeyleri açısından gruplar arasında anlamlı bir fark saptanmadı (p=0,285), ancak grup içi karşılaştırmalarda IL-35 düzeylerinin aşikar hipotiroidizme doğru giderek azaldığı görüldü. Grup içi karşılaştırmalarda, kontrol grubu ile aşikar hipotiroidizm grubu arasında istatistiksel olarak anlamlı bir fark belirlendi (550,05±411,50 ve 369,80±253,33; p=0,046). Hasta grupları tiroid uyarıcı hormon değerlerine göre gruplandırıldığında, eşik değeri ≥6 uIU/ mL olan gruplar ile bunun altındakiler arasında IL-35 düzeyleri açısından anlamlı fark saptandı (p=0,043). Eşik değeri ≥10 uIU/mL olanlar ve altındakilerden oluşan iki grup oluşturulduğunda, gruplar arasında IL-35 düzeyleri açısından daha anlamlı fark olduğu görüldü (p=0,024). Kontrol edilebilir faktörler (sigara, diabetes mellitus, hipertansiyon ve vücut kitle indeksi) dikkate alınarak yapılan korelasyon analizi sonucunda IL-35 seviyeleri ile antitiroid peroksidaz arasında düşük anlamlı bir korelasyon tespit edildi (p=0,029).Sonuç: Bu çalışmada HT’de rol oynayan bir antiinflamatuar sitokin olan IL-35 düzeylerinin ötiroid hasta grubundan aşikar hipotiroidi grubuna doğru giderek azaldığı belirlendi., Aim: In this study, it was aimed to examine interleukin-35 (IL-35) levels and their association with thyroid function tests in Hashimoto’s thyroiditis (HT).Material and Method: Included in the study were 128 individuals, between 18 and 65 years of age, who had been newly diagnosed with HT (euthyroid, subclinical hypothyroidism and overt hypothyroidism) and 38 health controls who had no known diseases or drug use.Result: No significant difference was determined between the groups in terms of the IL-35 levels (p=0.285), although in the in-group comparisons, the IL-35 levels were found to decrease progressively towards overt hypothyroidism. In the in-group comparisons, however, a statistically significant difference was determined between the control group and the overt hypothyroidism group (550.05±411.50 vs. 369.80±253.33; p=0.046). When the patient groups were grouped according to their thyroid stimulating hormone values, a significant difference was determined between the groups with a threshold value of ≥6 uIU/ mL and those below it, in terms of the IL-35 levels (p=0.043). When two groups were created, comprising those with a threshold value of ≥10 uIU/mL and those below it, it was observed that there was a more significant difference between the groups in terms of the IL-35 levels (p=0.024). As a result of the correlation analysis performed by taking into account the controllable factors (smoking, diabetes mellitus, hypertension, and body mass index), a low-significant correlation was determined between the IL-35 levels and antithyroid peroxidase (p=0.029).Conclusion: In this study, it was determined that the IL-35 levels, an antiinflammatory cytokine involved in HT, decreased progressively from the euthyroid patient group towards the overt hypothyroidism group.

Aim: To determine the effect of lactose intolerance on serum glucose levels and related biochemical parameters in the adult population who refrain from consuming milk and milk products. Material and Method: This retrospective, observational study was conducted in a tertiary care hospital between January 2016 and December 2019 with 296 participants. Plasma glucose, calcium, 25-hydroxyvitamin D3, folate, vitamin B12, thyroid-stimulating hormone (TSH), and ferritin levels were controlled. Patients with positive lactose intolerance test results were accepted as the study group and negative results were accepted as the control group, and data of two groups were compared. Results: Of the total 296 participants 212 (71.7%) were found to have lactose intolerance and 84 (28.3%) were found to be normal. In the lactose intolerant group, blood glucose levels were significantly lower than the control group (5.14±0.53 mmol/L versus 5.47±0.54 mmol/L, p