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51. Alternative Fistula Risk Score for Pancreatoduodenectomy (a-FRS) Design and International External Validation

Author

Mungroop, T.H., Rijssen, L.B. van, Klaveren, D. van, Smits, F.J., Woerden, V. van, Linnemann, R.J., Pastena, M. de, Klompmaker, S., Marchegiani, G., Ecker, B.L., Dieren, S. van, Bonsing, B., Busch, O.R., Dam, R.M. van, Erdmann, J., Eijck, C.H. van, Gerhards, M.E., Goor, H. van, Harst, E. van der, Hingh, I.H. de, Jong, K.P. de, Kazemier, G., Luyer, M., Shamali, A., Barbaro, S., Armstrong, T., Takhar, A., Hamady, Z., Klaase, J., Lips, D.J., Molenaar, I.Q., Nieuwenhuijs, V.B., Rupert, C., Santvoort, H.C. van, Scheepers, J.J., Schelling, G.P. van der, Bassi, C., Vollmer, C.M., Steyerberg, E.W., Abu Hilal, M., Koerkamp, B.G., Besselink, M.G., Dutch Pancreatic Canc Grp, Ear, Nose and Throat, CCA - Cancer Treatment and Quality of Life, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, AGEM - Endocrinology, metabolism and nutrition, Graduate School, Surgery, APH - Methodology, Promovendi NTM, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, CCA - Cancer Treatment and quality of life, Groningen Institute for Organ Transplantation (GIOT), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Value, Affordability and Sustainability (VALUE), and Public Health

Subjects
Male, medicine.medical_specialty, Internationality, LOGISTIC-REGRESSION ANALYSIS, PREDICTION, DRAINAGE, Fistula, medicine.medical_treatment, MODELS, complication, 030230 surgery, Gastroenterology, Risk Assessment, Pancreaticoduodenectomy, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, pancreatic fistula, BLOOD-LOSS, Internal medicine, Pancreatic cancer, POSTOPERATIVE PANCREATIC FISTULA, medicine, MANAGEMENT, Humans, pancreas, Aged, Pancreatic duct, Framingham Risk Score, business.industry, Odds ratio, PERFORMANCE, Middle Aged, medicine.disease, Confidence interval, prediction model, medicine.anatomical_structure, Pancreatic fistula, 030220 oncology & carcinogenesis, Surgery, Female, Pancreatic Fistula, business, SYSTEM
Abstract

Objective: The aim of this study was to develop an alternative fistula risk score (a-FRS) for postoperative pancreatic fistula (POPF) after pancreatoduodenectomy, without blood loss as a predictor.Background: Blood loss, one of the predictors of the original-FRS, was not a significant factor during 2 recent external validations.Methods: The a-FRS was developed in 2 databases: the Dutch Pancreatic Cancer Audit (18 centers) and the University Hospital Southampton NHS. Primary outcome was grade B/C POPF according to the 2005 International Study Group on Pancreatic Surgery (ISGPS) definition. The score was externally validated in 2 independent databases (University Hospital of Verona and University Hospital of Pennsylvania), using both 2005 and 2016 ISGPS definitions. The a-FRS was also compared with the original-FRS.Results: For model design, 1924 patients were included of whom 12% developed POPE Three predictors were strongly associated with POPF: soft pancreatic texture [odds ratio (OR) 2.58, 95% confidence interval (95% CI) 1.80-3.69], small pancreatic duct diameter (per mm increase, OR: 0.68, 95% CI: 0.61-0.76), and high body mass index (BMI) (per kg/m(2) increase, OR: 1.07, 95% CI: 1.04-1.11). Discrimination was adequate with an area under curve (AUC) of 0.75 (95% CI: 0.71-0.78) after internal validation, and 0.78 (0.74-0.82) after external validation. The predictive capacity of a-FRS was comparable with the original-FRS, both for the 2005 definition (AUC 0.78 vs 0.75, P = 0.03), and 2016 definition (AUC 0.72 vs 0.70, P = 0.05).Conclusion: The a-FRS predicts POPF after pancreatoduodenectomy based on 3 easily available variables (pancreatic texture, duct diameter, BMI) without blood loss and pathology, and was successfully validated for both the 2005 and 2016 POPF definition. The online calculator is available at www.pancreascalculator.com .

Published
2019
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52. Cross-Sectional Study on MRI Restaging After Chemoradiotherapy and Interval to Surgery in Rectal Cancer: Influence on Short- and Long-Term Outcomes

Author

Detering, R., Borstlap, W.A.A., Broeders, L., Hermus, L., Marijnen, C.A.M., Beets-Tan, R.G.H., Bemelman, W.A., Westreenen, H.L. van, Tanis, P.J., Aalbers, A., Acherman, Y., Algie, G.D., Geusau, B.A. von, Amelung, F., Bartels, S.A., Basha, S., Bastiaansen, A.J.N.M., Belgers, E., Bleeker, W., Blok, J., Bosker, R.J.I., Bosmans, J.W., Boute, M.C., Bouvy, N.D., Bouwman, H., Brandt-Kerkhof, A., Brinkman, D.J., Bruin, S., Bruns, E.R.J., Burbach, J.P.M., Burger, J.W.A., Buskens, C.J., Clermonts, S., Coene, P.P.L.O., Compaan, C., Consten, E.C.J., Darbyshire, T., Mik, S.M.L. de, Graaf, E.J.R. de, Groot, I. de, Cappel, R.J.L.D.T.N., Wilt, J.H.W. de, Wolde, J. van der, Boer, F.C. den, Dekker, J.W.T., Demirkiran, A., Derkx-Hendriksen, M., Dijkstra, F.R., Duijvendijk, P. van, Dunker, M.S., Eijsbouts, Q.E., Fabry, H., Ferenschild, F., Foppen, J.W., Gerhards, M.F., Gerven, P., Gooszen, J.A.H., Govaert, J.A., Grevenstein, W.M.U. van, Haen, R., Harlaar, J.J., Harst, E., Havenga, K., Heemskerk, J., Heeren, J.F., Heijnen, B., Heres, P., Hoff, C., Hogendoorn, W., Hoogland, P., Huijbers, A., Janssen, P., Jongen, A.C., Jonker, F.H., Karthaus, E.G., Keijzer, A., Ketel, J.M.A., Klaase, J., Wit, F., Kloppenberg, H., Kool, M.E., Kortekaas, R., Kruyt, P.M., Kuiper, J.T., Lamme, B., Lange, J.F., Lettinga, T., Lips, D.J., Logeman, F., Holzik, M.F.L., Madsen, E., Mamound, A., Marres, C.C., Masselink, I., Meerdink, M., Menon, A.G., Mieog, J.S., Mierlo, D., Musters, G.D., Nieuwenhuijzen, G.A.P., Neijenhuis, P.A., Nonner, J., Oostdijk, M., Paul, P.M.P., Peeters, K.C.M.J., Pereboom, I.T.A., Polat, F., Poortman, P., Raber, M., Reiber, B.M.M., Renger, R.J., Rossem, C.C. van, Rutten, H.J., Rutten, A., Schaapman, R., Scheer, M., Schoonderwoerd, L., Schouten, N., Schreuder, A.M., Schreurs, W.H., Simkens, G.A., Slooter, G.D., Sluijmer, H.C.E., Smakman, N., Smeenk, R., Snijders, H.S., Sonneveld, D.J.A., Spaansen, B., Bilgen, E.J.S., Steller, E., Steup, W.H., Steur, C., Stortelder, E., Straatman, J., Swank, H.A., Sietses, C., Berge, H.A. ten, Hoeve, H.G. ten, Riele, W.W. ter, Thorensen, I.M., Tip-Pluijm, B., Toorenvliet, B.R., Tseng, L., Tuynman, J.B., Bastelaar, J. van, Beek, S.C. van, Ven, A.W.H. van de, Weijer, M.A.J. van de, Berg, C. van den, Bosch, I. van den, Bilt, J.D.W. van der, Hagen, S.J. van der, Hul, R. van der, Schelling, G. van der, Spek, A. van der, Wielen, N. van der, Duyn, E. van, Eekelen, C. van, Essen, J.A. van, Gangelt, K. van, Geloven, A.A.W. van, Kessel, C. van, Loon, Y.T. van, Rijswijk, A. van, Rooijen, S.J. van, Sprundel, T. van, Steensel, L. van, Tets, W.F. van, Veltkamp, S., Verhaak, T., Verheijen, P.M., Versluis-Ossenwaarde, L., Vijfhuize, S., Vles, W.J., Voeten, S.C., Vogelaar, F.J., Vrijland, W.W., Westerduin, E., Westerterp, M.E., Wetzel, M., Wevers, K.P., Wiering, B., Witjes, C.D.M., Wouters, M.W., Yauw, S.T.K., Zaag, E.S. van der, Zeestraten, E.C., Zimmerman, D.D., Zwieten, T., Dutch Snapshot Res Grp, Groningen Institute for Organ Transplantation (GIOT), Value, Affordability and Sustainability (VALUE), ​Robotics and image-guided minimally-invasive surgery (ROBOTICS), CCA - Cancer Treatment and quality of life, Surgery, Amsterdam Reproduction & Development (AR&D), and Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
Male, IMPACT, medicine.medical_treatment, THERAPY, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], CHEMORADIATION, 0302 clinical medicine, ADJUVANT CHEMOTHERAPY, Interquartile range, Medicine, PATHOLOGICAL COMPLETE RESPONSE, Stage (cooking), Neoadjuvant therapy, Netherlands, Aged, 80 and over, medicine.diagnostic_test, Incidence, ASO Author Reflections, Chemoradiotherapy, Middle Aged, Magnetic Resonance Imaging, Neoadjuvant Therapy, Survival Rate, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Surgical Procedures, Operative, SURVIVAL, 030211 gastroenterology & hepatology, Female, TIME-INTERVAL, RADIOTHERAPY, medicine.medical_specialty, RESECTION, Preoperative care, Time-to-Treatment, 03 medical and health sciences, Preoperative Care, Humans, Survival rate, Aged, Neoplasm Staging, Retrospective Studies, business.industry, Rectal Neoplasms, Magnetic resonance imaging, Retrospective cohort study, NEOADJUVANT CHEMORADIOTHERAPY, Surgery, Cross-Sectional Studies, Neoplasm Recurrence, Local, business, Follow-Up Studies
Abstract

Contains fulltext : 215772.pdf (Publisher’s version ) (Open Access) BACKGROUND: The time interval between CRT and surgery in rectal cancer patients is still the subject of debate. The aim of this study was to first evaluate the nationwide use of restaging magnetic resonance imaging (MRI) and its impact on timing of surgery, and, second, to evaluate the impact of timing of surgery after chemoradiotherapy (CRT) on short- and long-term outcomes. METHODS: Patients were selected from a collaborative rectal cancer research project including 71 Dutch centres, and were subdivided into two groups according to time interval from the start of preoperative CRT to surgery (< 14 and >/= 14 weeks). RESULTS: From 2095 registered patients, 475 patients received preoperative CRT. MRI restaging was performed in 79.4% of patients, with a median CRT-MRI interval of 10 weeks (interquartile range [IQR] 8-11) and a median MRI-surgery interval of 4 weeks (IQR 2-5). The CRT-surgery interval groups consisted of 224 (< 14 weeks) and 251 patients (>/= 14 weeks), and the long-interval group included a higher proportion of cT4 stage and multivisceral resection patients. Pathological complete response rate (n = 34 [15.2%] vs. n = 47 [18.7%], p = 0.305) and CRM involvement (9.7% vs. 15.9%, p = 0.145) did not significantly differ. Thirty-day surgical complications were similar (20.1% vs. 23.1%, p = 0.943), however no significant differences were found for local and distant recurrence rates, disease-free survival, and overall survival. CONCLUSIONS: These real-life data, reflecting routine daily practice in The Netherlands, showed substantial variability in the use and timing of restaging MRI after preoperative CRT for rectal cancer, as well as time interval to surgery. Surgery before or after 14 weeks from the start of CRT resulted in similar short- and long-term outcomes.

Published
2019
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55. Volume-outcome relationship of liver surgery:a nationwide analysis

Author

Olthof, P B, Elfrink, A K E, Marra, E, Belt, E J T, van den Boezem, P B, Bosscha, K, Consten, E C J, den Dulk, M, Gobardhan, P D, Hagendoorn, J, van Heek, T N T, IJzermans, J N M, Klaase, J M, Kuhlmann, K F D, Leclercq, W K G, Liem, M S L, Manusama, E R, Marsman, H A, Mieog, J S D, Oosterling, S J, Patijn, G A, Te Riele, W, Swijnenburg, R-J, Torrenga, H, van Duijvendijk, P, Vermaas, M, Kok, N F M, Grünhagen, D J, Olthof, P B, Elfrink, A K E, Marra, E, Belt, E J T, van den Boezem, P B, Bosscha, K, Consten, E C J, den Dulk, M, Gobardhan, P D, Hagendoorn, J, van Heek, T N T, IJzermans, J N M, Klaase, J M, Kuhlmann, K F D, Leclercq, W K G, Liem, M S L, Manusama, E R, Marsman, H A, Mieog, J S D, Oosterling, S J, Patijn, G A, Te Riele, W, Swijnenburg, R-J, Torrenga, H, van Duijvendijk, P, Vermaas, M, Kok, N F M, and Grünhagen, D J

Abstract

BACKGROUND: Evidence for an association between hospital volume and outcomes for liver surgery is abundant. The current Dutch guideline requires a minimum volume of 20 annual procedures per centre. The aim of this study was to investigate the association between hospital volume and postoperative outcomes using data from the nationwide Dutch Hepato Biliary Audit.METHODS: This was a nationwide study in the Netherlands. All liver resections reported in the Dutch Hepato Biliary Audit between 2014 and 2017 were included. Annual centre volume was calculated and classified in categories of 20 procedures per year. Main outcomes were major morbidity (Clavien-Dindo grade IIIA or higher) and 30-day or in-hospital mortality.RESULTS: A total of 5590 liver resections were done across 34 centres with a median annual centre volume of 35 (i.q.r. 20-69) procedures. Overall major morbidity and mortality rates were 11·2 and 2·0 per cent respectively. The mortality rate was 1·9 per cent after resection for colorectal liver metastases (CRLMs), 1·2 per cent for non-CRLMs, 0·4 per cent for benign tumours, 4·9 per cent for hepatocellular carcinoma and 10·3 per cent for biliary tumours. Higher-volume centres performed more major liver resections, and more resections for hepatocellular carcinoma and biliary cancer. There was no association between hospital volume and either major morbidity or mortality in multivariable analysis, after adjustment for known risk factors for adverse events.CONCLUSION: Hospital volume and postoperative outcomes were not associated.

Published
2020

56. Preoperative imaging for colorectal liver metastases:a nationwide population-based study

Author

Elfrink, A K E, Pool, M, van der Werf, L R, Marra, E, Burgmans, M C, Meijerink, M R, den Dulk, M, van den Boezem, P B, Te Riele, W W, Patijn, G A, Wouters, M W J M, Leclercq, W K G, Liem, M S L, Gobardhan, P D, Buis, C I, Kuhlmann, K F D, Verhoef, C, Besselink, M G, Grünhagen, D J, Klaase, J M, Kok, N F M, Elfrink, A K E, Pool, M, van der Werf, L R, Marra, E, Burgmans, M C, Meijerink, M R, den Dulk, M, van den Boezem, P B, Te Riele, W W, Patijn, G A, Wouters, M W J M, Leclercq, W K G, Liem, M S L, Gobardhan, P D, Buis, C I, Kuhlmann, K F D, Verhoef, C, Besselink, M G, Grünhagen, D J, Klaase, J M, and Kok, N F M

Abstract

BACKGROUND: In patients with colorectal liver metastases (CRLM) preoperative imaging may include contrast-enhanced (ce) MRI and [18 F]fluorodeoxyglucose (18 F-FDG) PET-CT. This study assessed trends and variation between hospitals and oncological networks in the use of preoperative imaging in the Netherlands.METHODS: Data for all patients who underwent liver resection for CRLM in the Netherlands between 2014 and 2018 were retrieved from a nationwide auditing database. Multivariable logistic regression analysis was used to assess use of ceMRI, 18 F-FDG PET-CT and combined ceMRI and 18 F-FDG PET-CT, and trends in preoperative imaging and hospital and oncological network variation.RESULTS: A total of 4510 patients were included, of whom 1562 had ceMRI, 872 had 18 F-FDG PET-CT, and 1293 had combined ceMRI and 18 F-FDG PET-CT. Use of ceMRI increased over time (from 9·6 to 26·2 per cent; P < 0·001), use of 18 F-FDG PET-CT decreased (from 28·6 to 6·0 per cent; P < 0·001), and use of both ceMRI and 18 F-FDG PET-CT 16·9 per cent) remained stable. Unadjusted variation in the use of ceMRI, 18 F-FDG PET-CT, and combined ceMRI and 18 F-FDG PET-CT ranged from 5·6 to 100 per cent between hospitals. After case-mix correction, hospital and oncological network variation was found for all imaging modalities.DISCUSSION: Significant variation exists concerning the use of preoperative imaging for CRLM between hospitals and oncological networks in the Netherlands. The use of MRI is increasing, whereas that of 18 F-FDG PET-CT is decreasing.

Published
2020

63. Conditional survival after resection of pancreatic cancer: A population-based study

Author

Latenstein, A., primary, Van der Geest, L., additional, Van Dam, R., additional, Koerkamp, B. Groot, additional, De Hingh, I., additional, Homs, M., additional, Klaase, J., additional, Bonsing, B., additional, Lemmens, V., additional, Molenaar, I., additional, Stommel, M., additional, Busch, O., additional, Van Eijck, C., additional, Van Laarhoven, H., additional, Wilmink, J., additional, and Besselink, M., additional

Published
2020
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64. Implementation and outcomes of a national liver surgeons expert panel to determine secondary resectability in patients with initially unresectable colorectal liver metastases (CRLM)

Author

Swijnenburg, R., primary, Bolhuis, K., additional, Huiskens, J., additional, Van Lienden, K., additional, Engelbrecht, M., additional, Van Amerongen, M., additional, Heijmen, L., additional, Hermans, J., additional, Molenaar, Q., additional, Verhoef, C., additional, Grünhagen, D., additional, De Jong, K., additional, Klaase, J., additional, Dejong, C., additional, Kazemier, G., additional, Ruers, T., additional, De Wilt, H., additional, Rijken, A., additional, Gerhards, M., additional, Liem, M., additional, Patijn, G., additional, Punt, C., additional, and Van Gulik, T., additional

Published
2020
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66. Outcome including long-term quality of life after total pancreatectomy (PANORAMA): a nationwide cohort study

Author

Latenstein, A., primary, Scholten, L., additional, Van Hooft, J., additional, Bonsing, B., additional, Bosscha, K., additional, Coene, P., additional, Van Dam, R., additional, Van Dieren, S., additional, Van Eijck, C., additional, Erdmann, J., additional, Gerhards, M., additional, Van Goor, H., additional, Van der Harst, E., additional, De Hingh, I., additional, Kazemier, G., additional, Klaase, J., additional, Mieog, S., additional, Molenaar, I., additional, Patijn, G., additional, Van Santvoort, H., additional, Scheepers, J., additional, Van der Schelling, G., additional, Busch, O., additional, Pranger, B., additional, Snoek, F., additional, De Vries, J., additional, and Besselink, M., additional

Published
2020
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67. Treatment and survival of locally recurrent rectal cancer: A cross-sectional population study 15 years after the Dutch TME trial

Author

Detering, Robin, primary, Karthaus, Eleonora G., additional, Borstlap, Wernard A.A., additional, Marijnen, Corrie A.M., additional, van de Velde, Cornelis J.H., additional, Bemelman, Willem A., additional, Beets, Geerard L., additional, Tanis, Pieter J., additional, Aalbers, Arend G.J., additional, Aalbers, A.G.J., additional, Acherman, Y., additional, Algie, G.D., additional, Alting von Geusau, B., additional, Amelung, F., additional, Aukema, T.S., additional, Bakker, I.S., additional, Bartels, S.A., additional, Basha, S., additional, Bastiaansen, A.J.N.M., additional, Belgers, E., additional, Bleeker, W., additional, Blok, J., additional, Bosker, R.J.I., additional, Bosmans, J.W., additional, Boute, M.C., additional, Bouvy, N.D., additional, Bouwman, H., additional, Brandt-Kerkhof, A., additional, Brinkman, D.J., additional, Bruin, S., additional, Bruns, E.R.J., additional, Burbach, J.P.M., additional, Burger, J.W.A., additional, Buskens, C.J., additional, Clermonts, S., additional, Coene, P.P.L.O., additional, Compaan, C., additional, Consten, E.C.J., additional, Darbyshire, T., additional, de Mik, S.M.L., additional, de Graaf, E.J.R., additional, de Groot, I., additional, tot Nederveen Cappel, RJ de Vos, additional, de Wilt, J.H.W., additional, van der Wolde, J., additional, Boer, FC den, additional, Dekker, J.W.T., additional, Demirkiran, A., additional, Derkx-Hendriksen, M., additional, Dijkstra, F.R., additional, van Duijvendijk, P., additional, Dunker, M.S., additional, Eijsbouts, Q.E., additional, Fabry, H., additional, Ferenschild, F., additional, Foppen, J.W., additional, Furnee, E.J.B., additional, Gerhards, M.F., additional, Gerven, P., additional, Gooszen, J.A.H., additional, Govaert, J.A., additional, Van Grevenstein, W.M.U., additional, Haen, R., additional, Harlaar, J.J., additional, van der Harst, E., additional, Havenga, K., additional, Heemskerk, J., additional, Heeren, J.F., additional, Heijnen, B., additional, Heres, P., additional, Hoff, C., additional, Hogendoorn, W., additional, Hoogland, P., additional, Huijbers, A., additional, Janssen, P., additional, Jongen, A.C., additional, Jonker, F.H., additional, Karthaus, E.G., additional, Keijzer, A., additional, Ketel, J.M.A., additional, Klaase, J., additional, Kloppenberg, F.W.H., additional, Kool, M.E., additional, Kortekaas, R., additional, Kruyt, P.M., additional, Kuiper, J.T., additional, Lamme, B., additional, Lange, J.F., additional, Lettinga, T., additional, Lips, D.J., additional, Logeman, F., additional, Lutke Holzik, M.F., additional, Madsen, E., additional, Mamound, A., additional, Marres, C.C., additional, Masselink, I., additional, Meerdink, M., additional, Menon, A.G., additional, Mieog, J.S., additional, Mierlo, D., additional, Musters, G.D., additional, Nieuwenhuijzen, G.A.P., additional, Neijenhuis, P.A., additional, Nonner, J., additional, Oostdijk, M., additional, Oosterling, S.J., additional, Paul, P.M.P., additional, Peeters, K.C.M.J., additional, Pereboom, I.T.A., additional, Polat, F., additional, Poortman, P., additional, Raber, M., additional, Reiber, B.M.M., additional, Renger, R.J., additional, van Rossem, C.C., additional, Rutten, H.J., additional, Rutten, A., additional, Schaapman, R., additional, Scheer, M., additional, Schoonderwoerd, L., additional, Schouten, N., additional, Schreuder, A.M., additional, Schreurs, W.H., additional, Simkens, G.A., additional, Slooter, G.D., additional, Sluijmer, H.C.E., additional, Smakman, N., additional, Smeenk, R., additional, Snijders, H.S., additional, Sonneveld, D.J.A., additional, Spaansen, B., additional, Bilgen, EJ Spillenaar, additional, Steller, E., additional, Steup, W.H., additional, Steur, C., additional, Stortelder, E., additional, Straatman, J., additional, Swank, H.A., additional, Sietses, C., additional, Groen, H.A., additional, Hoeve, HG ten, additional, Riele, WW ter, additional, Thorensen, I.M., additional, Tip-Pluijm, B., additional, Toorenvliet, B.R., additional, Tseng, L., additional, Tuynman, J.B., additional, van Bastelaar, J., additional, van Beek, S.C., additional, van de Ven, A.W.H., additional, van de Weijer, M.A.J., additional, van den Berg, C., additional, van den Bosch, I., additional, van der Bilt, J.D.W., additional, van der Hagen, S.J., additional, van der Hul, R., additional, van der Schelling, G., additional, van der Spek, A., additional, van der Wielen, N., additional, van Duyn, E., additional, van Eekelen, C., additional, van Essen, J.A., additional, van Gangelt, K., additional, van Geloven, A.A.W., additional, van Kessel, C., additional, van Loon, Y.T., additional, van Rijswijk, A., additional, van Rooijen, S.J., additional, van Sprundel, T., additional, van Steensel, L., additional, van Tets, W.F., additional, van Westreenen, H.L., additional, Veltkamp, S., additional, Verhaak, T., additional, Verheijen, P.M., additional, Versluis-Ossenwaarde, L., additional, Vijfhuize, S., additional, Vles, W.J., additional, Voeten, S.C., additional, Vogelaar, F.J., additional, Vrijland, W.W., additional, Westerduin, E., additional, Westerterp, M.E., additional, Wetzel, M., additional, Wevers, K.P., additional, Wiering, B., additional, Witjes, C.D.M., additional, Wouters, M.W., additional, Yauw, S.T.K., additional, van der Zaag, E.S., additional, Zeestraten, E.C., additional, Zimmerman, D.D.E., additional, and Zwieten, T., additional

Published
2019
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68. Propensity score-matched analysis of oncological outcome between stent as bridge to surgery and emergency resection in patients with malignant left-sided colonic obstruction

Author

Amelung, F J, primary, Borstlap, W A A, additional, Consten, E C J, additional, Veld, J V, additional, van Halsema, E E, additional, Bemelman, W A, additional, Siersema, P D, additional, ter Borg, F, additional, van Hooft, J E, additional, Tanis, P J, additional, Algera, H, additional, Algie, G D, additional, Andeweg, C S, additional, Argillander, T, additional, Arron, M N N J, additional, Arts, K, additional, Aufenacker, T H J, additional, Bakker, I S, additional, Basten Batenburg, M, additional, Bastiaansen, A J N M, additional, Beets, G L, additional, Berg, A, additional, Beukel, B, additional, Blom, R L G M, additional, Blomberg, B, additional, Boerma, E G, additional, Boer, F C, additional, Bouvy, N D, additional, Bouwman, J E, additional, Boye, N D A, additional, Brandt, A R M, additional, Brandsma, H T, additional, Breijer, A, additional, Broek, W, additional, Bröker, M E E, additional, Burbach, J P M, additional, Bruns, E R J, additional, Burghgraef, T A, additional, Crolla, R M P H, additional, Dam, M, additional, Daniels, L, additional, Dekker, J W T, additional, Demirkiran, A, additional, Dongen, K, additional, Durmaz, S F, additional, Esch, A, additional, Essen, J A, additional, Foppen, J W, additional, Furnee, E J B, additional, Geloven, A A W, additional, Gerhards, M F, additional, Gorter, E A, additional, Grevenstein, W M U, additional, Groningen, J, additional, Groot, I, additional, Haak, H, additional, Haas, J W A, additional, Hagen, P, additional, Hamminga, J T H, additional, Havenga, K, additional, Hengel, B, additional, Harst, E, additional, Heemskerk, J, additional, Heeren, J, additional, Heijnen, B H M, additional, Heijnen, L, additional, Heikens, J T, additional, Heinsbergen, M, additional, Hess, D A, additional, Heuchemer, N, additional, Hoff, C, additional, Hogendoorn, W, additional, Houdijk, A P J, additional, Hugen, N, additional, Inberg, B, additional, Janssen, T, additional, Pierre, D Jean, additional, Jong, W J, additional, Jongen, A C H M, additional, Kamman, A V, additional, Klaase, J M, additional, Kelder, W, additional, Kelling, E F, additional, Klicks, R, additional, De Klein, G W, additional, Kloppenberg, F W H, additional, Konsten, J L M, additional, Koolen, L J E R, additional, Kornmann, V, additional, Kortekaas, R T J, additional, Kreiter, A, additional, Lamme, B, additional, Lange, J F, additional, Lettinga, T, additional, Lips, D, additional, Lo, G, additional, Logeman, F, additional, Loon, Y T, additional, Holzik, M F Lutke, additional, Marres, C C M, additional, Masselink, I, additional, Mearadji, A, additional, Meisen, G, additional, Menon, A G, additional, Merkus, J, additional, Mey, D, additional, Mijle, H C J, additional, Moes, D E, additional, Molenaar, C, additional, Nieboer, M J, additional, Nielsen, K, additional, Nieuwenhuijzen, G A P, additional, Neijenhuis, P A, additional, Oomen, P, additional, Oorschot, N, additional, Parry, K, additional, Peeters, K C M J, additional, Paulides, T, additional, Paulusma, I, additional, Poelmann, F B, additional, Polle, S W, additional, Poortman, P, additional, Raber, M, additional, Renger, R J, additional, Reiber, B M M, additional, Roukema, R, additional, Ruijter, W M J, additional, Russchen, M J A M, additional, Rutten, H J T, additional, Scheerhoorn, J, additional, Scheurs, S, additional, Schippers, H, additional, Schuermans, V N E, additional, Schuijt, H J, additional, Sierink, J C, additional, Sietses, C, additional, Silvis, R, additional, Slegt, J, additional, Slooter, G, additional, Sluis, M, additional, Sluis, P, additional, Smakman, N, additional, Smit, D, additional, Sprundel, T C, additional, Sonneveld, D J A, additional, Steur, C, additional, Straatman, J, additional, Struijs, M C, additional, Swank, H A, additional, Talsma, A K, additional, Tenhagen, M, additional, Tol, J A M G, additional, Tolenaar, J L, additional, Tseng, L, additional, Tuynman, J B, additional, Veen, M J F, additional, Veltkamp, S, additional, Ven, A W H, additional, Verkoele, L, additional, Vermaas, M, additional, Versteegh, H P, additional, Versluijs, L, additional, Visser, T, additional, Uden, D, additional, Vles, W J, additional, Vos tot Nederveen Cappel, R, additional, Vries, H S, additional, Vugt, S T, additional, Vugts, G, additional, Wegdam, J A, additional, Weijs, T, additional, Wely, B J, additional, Werker, C, additional, Westerterp, M, additional, Westreenen, H L, additional, Wiering, B, additional, Wijffels, N A T, additional, Wijkman, A A, additional, Wijngaarden, L H, additional, Wilt, J H W, additional, Wilt, M, additional, Wisselink, D D, additional, Wit, F, additional, Zaag, E S, additional, Zimmerman, D, additional, and Zwols, T, additional

Published
2019
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69. Prognostic impact of repeat sentinel lymph node biopsy in patients with ipsilateral breast tumour recurrence

Author

Poodt, I G M, primary, Vugts, G, additional, Schipper, R J, additional, Roumen, R M H, additional, Rutten, H J T, additional, Maaskant-Braat, A J G, additional, Voogd, A C, additional, Nieuwenhuijzen, G A P, additional, Luiten, E J T, additional, Rutgers, E J T, additional, Vrancken-Peeters, M T F D, additional, Bessems, M, additional, Klaase, J M, additional, Muller, S, additional, Francken, A B, additional, Van Dalen, T, additional, Jansen, L, additional, Koopal, S A, additional, Vissers, Y L J, additional, Smidt, M L, additional, Merkus, J W S, additional, Contant, C M E, additional, Veldman, P H, additional, Linthorst-Niers, E M H, additional, van der Sijp, J R, additional, Guicherit, O R, additional, Koppert, L B, additional, Bosch, A M, additional, Strobbe, L J A, additional, Schlooz-Vries, M S, additional, Arntz, I E, additional, van Essen, J A, additional, de Waard, J W D, additional, Vrouenraets, B C, additional, and van Ooijen, B, additional

Published
2019
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70. Costs and quality of life in a randomized trial comparing minimally invasive and open distal pancreatectomy (LEOPARD trial)

Author

Perfusie, MS CGO, Cancer, van Hilst, J., Strating, E. A., de Rooij, T., Daams, F., Festen, S., Groot Koerkamp, B., Klaase, J. M., Luyer, M., Dijkgraaf, M. G., Besselink, M. G., on behalf of the Dutch Pancreatic Cancer Group and LEOPARD trial collaborators, Perfusie, MS CGO, Cancer, van Hilst, J., Strating, E. A., de Rooij, T., Daams, F., Festen, S., Groot Koerkamp, B., Klaase, J. M., Luyer, M., Dijkgraaf, M. G., Besselink, M. G., and on behalf of the Dutch Pancreatic Cancer Group and LEOPARD trial collaborators

Published
2019

71. Benchmarking recent national practice in rectal cancer treatment with landmark randomized controlled trials

Author

Borstlap, W.A.A., Deijen, C.L., Dulk, M. den, Bonjer, H.J., Velde, C.J. van de, Bemelman, W.A., Tanis, P.J., Aalbers, A., Acherman, Y., Algie, G.D., Geu-sau, B.A. von, Amelung, F., Aukema, T.S., Bakker, I.S., Bartels, S.A., Basha, S., Bastiaansen, A.J.N.M., Belgers, E., Bleeker, W., Blok, J., Bosker, R.J.I., Bosmans, J.W., Boute, M.C., Bouvy, N.D., Bouwman, H., Brandt-Kerkhof, A., Brinkman, D.J., Bruin, S., Bruns, E.R.J., Burbach, J.P.M., Burger, J.W.A., Buskens, C.J., Clermonts, S., Coene, P.P.L.O., Compaan, C., Consten, E.C.J., Darbyshire, T., Mik, S.M.L. de, Graaf, E.J.R. de, Groot, I. de, Cappel, R.J.L.D.T.N., Wilt, J.H.W. de, Wolde, J. van der, Boer, F.C. den, Dekker, J.W.T., Demirkiran, A., Derkx-Hendriksen, M., Dijkstra, F.R., Duijvendijk, P. van, Dunker, M.S., Eijsbouts, Q.E., Fabry, H., Ferenschild, F., Foppen, J.W., Furnee, E.J.B., Gerhards, M.F., Gerven, P., Gooszen, J.A.H., Govaert, J.A., Grevenstein, W.M.U. van, Haen, R., Harlaar, J.J., Harst, E., Havenga, K., Heemskerk, J., Heeren, J.F., Heijnen, B., Heres, P., Hoff, C., Hogendoorn, W., Hoogland, P., Huijbers, A., Janssen, P., Jongen, A.C., Jonker, F.H., Karthaus, E.G., Keijzer, A., Ketel, J.M.A., Klaase, J., Kloppenberg, F.W.H., Kool, M.E., Kortekaas, R., Kruyt, P.M., Kuiper, J.T., Lamme, B., Lange, J.F., Lettinga, T., Lips, D.J., Logeman, F., Holzik, M.F.L., Madsen, E., Mamound, A., Marres, C.C., Masselink, I., Meerdink, M., Menon, A.G., Mieog, J.S., Mierlo, D., Musters, G.D., Neijenhuis, P.A., Nonner, J., Oostdijk, M., Oosterling, S.J., Paul, P.M.P., Peeters, K.C.M.J.C., Pereboom, I.T.A., Polat, F., Poortman, P., Raber, M., Reiber, B.M.M., Renger, R.J., Rossem, C.C. van, Rutten, H.J., Rutten, A., Schaapman, R., Scheer, M., Schoonderwoerd, L., Schouten, N., Schreuder, A.M., Schreurs, W.H., Simkens, G.A., Slooter, G.D., Sluijmer, H.C.E., Smakman, N., Smeenk, R., Snijders, H.S., Sonneveld, D.J.A., Spaansen, B., Bilgen, E.J.S., Steller, E., Steup, W.H., Steur, C., Stortelder, E., Straatman, J., Swank, H.A., Sietses, C., Berge, H.A. ten, Hoeve, H.G. ten, Riele, W.W. ter, Thorensen, I.M., Tip-Pluijm, B., Toorenvliet, B.R., Tseng, L., Tuynman, J.B., Bastelaar, J. van, Beek, S.V. van, Ven, A.W.H. van de, Weijer, M.A.J. van de, Berg, C. van den, Bosch, I. van den, Bilt, J.D.W. van der, Hagen, S.J. van der, Hul, R. van der, Schelling, G. van der, Spek, A. van der, Wielen, N. van der, Duyn, E. van, Eekelen, C. van, Essen, J.A. van, Gangelt, K. van, Geloven, A.A.W. van, Kessel, C. van, Loon, Y.T. van, Rijswijk, A. van, Rooijen, S.J. van, Sprundel, T. van, Steensel, L. van, Tets, W.F. van, Westreenen, H.L. van, Veltkamp, S., Verhaak, T., Verheijen, P.M., Versluis-Ossenwaarde, L., Vijfhuize, S., Vles, W.J., Voeten, S., Vogelaar, F.J., Vrijland, W.W., Westerduin, E., Westerterp, M.E., Wetzel, M., Wevers, K., Wiering, B., Witjes, A.C., Wouters, M.W., Yauw, S.T.K., Zeestraten, E.C., Zimmerman, D.D., Zwieten, T., and Dutch Snapshot Res Grp

Subjects
oncologic outcomes, snapshot study, Rectal cancer
Abstract

Aim A Snapshot study design eliminates changes in treatment and outcome over time. This population based Snapshot study aimed to determine current practice and outcome of rectal cancer treatment with published landmark randomized controlled trials as a benchmark.Method In this collaborative research project, the dataset of the Dutch Surgical Colorectal Audit was extended with additional treatment and long-term outcome data. All registered patients who underwent resection for rectal cancer in 2011 were eligible. Baseline characteristics and outcome were evaluated against the results of the Dutch TME trial and the COLOR II trial from which the original datasets were obtained.Results A total of 71 hospitals participated, and data were completed for 2102 out of the potential 2633 patients (79.8%). Median follow-up was 41 (interquartile range 25-47) months. Overall circumferential resection margin (CRM) involvement was 9.3% in the Snapshot cohort and 18.5% in the Dutch TME trial. CRM positivity after laparoscopic resection was 7.8% in the Snapshot and 9.5% in the COLOR II trial. Three-year overall local recurrence rate in the Snapshot was 5.9%, with a disease-free survival of 67.1% and overall survival of 79.5%. Benchmarking with the randomized controlled trials revealed an overall favourable long-term outcome of the Snapshot cohort.Conclusion This study showed that current rectal cancer care in a large unselected Dutch population is of high quality, with less positive CRM since the TME trial and oncologically safe implementation of minimally invasive surgery after the COLOR II trial.

Published
2017

72. Benchmarking recent national practice in rectal cancer treatment with landmark randomized controlled trials

Author

Borstlap, W.A., Deijen, C.L., Dulk, M. den, Bonjer, H.J., Velde, C.J. van de, Bemelman, W.A., Tanis, P.J., Aalbers, A., Acherman, Y., Algie, G.D., Geu-sau, B. von, Amelung, F., Aukema, T.S., Bakker, I.S., Bartels, S.A., Basha, S., Bastiaansen, A.J., Belgers, E.H.J., Bleeker, W., Blok, J., Bosker, R.J.I., Bosmans, J.W., Boute, M.C., Bouvy, N.D., Bouwman, H., Brandt-Kerkhof, A., Brinkman, D.J., Bruin, S., Bruns, E.R.J., Burbach, J.P.M., Burger, J.W., Buskens, C.J., Clermonts, S., Coene, P.P.L.O., Compaan, C., Consten, E.C., Darbyshire, T., Mik, S.M.L. de, Graaf, E.J. de, Groot, I de, Cappel de Vos Tot Nederveen, R.J.L., Wilt, J.H.W. de, Wolde, J. van der, Boer, F.C. den, Dekker, J.W.T., Demirkiran, A., Derkx-Hendriksen, M., Dijkstra, F.R., Duijvendijk, P. van, Dunker, M.S., Eijsbouts, Q.E., Fabry, H., Ferenschild, F.T.J., Foppen, J.W., Furnee, E.J.B., Gerhards, M.F., Gerven, P, Gooszen, J.A.H., Govaert, J.A., Grevenstein, W.M. van, Haen, R., Harlaar, J.J., Harst, E, Havenga, K., Heemskerk, J., Heeren, J.F., Heijnen, B., Heres, P., Hoff, C., Hogendoorn, W., Hoogland, P., Huijbers, A, Janssen, P., Jongen, A.C., Jonker, F.H., Karthaus, E.G., Keijzer, A, Ketel, J.M.A., Klaase, J., Kloppenberg, F.W.H., Kool, M.E., Kortekaas, R., Kruyt, P.M., Kuiper, J.T., Lamme, B., Lange, J.F., Lettinga, T., Lips, D.J., Logeman, F., Holzik, M.F., Madsen, E., Mamound, A., Marres, C.C., Masselink, I., Meerdink, M., Menon, A.G., Mieog, J.S., Mierlo, D. van, Musters, G.D., Neijenhuis, P.A., Nonner, J., Oostdijk, M, Oosterling, S.J., Paul, P.M.P., Peeters, K.C., Pereboom, I.T.A., Polat, F., Poortman, P., Raber, M., Reiber, B.M.M., Renger, R.J., Rossem, C.C. van, Rutten, H.J., Rutten, A., Schaapman, R., Scheer, M.G.W., Schoonderwoerd, L., Schouten, N., Schreuder, A.M., Schreurs, W.H., Simkens, G.A., Slooter, G.D., Sluijmer, H.C.E., Smakman, N., Smeenk, R., Snijders, H.S., Sonneveld, D.J.A., Spaansen, B., Spillenaar Bilgen, E.J., Steller, E., Steup, W.H., Steur, C., Stortelder, E., Straatman, J., Swank, H.A., Sietses, C., Berge, H.A. ten, Hoeve, H.G. ten, Riele, W.W. ter, Thorensen, I.M., Tip-Pluijm, B., Toorenvliet, B.R., Tseng, L., Tuynman, J.B., Bastelaar, J. van, Beek, S.V. van, Ven, A.W.H. van de, Weijer, M.A.J. van de, Berg, C. van den, Bosch, I. van den, Bilt, J.D.W. van der, Hagen, S.J. van der, Hul, R. van der, Schelling, G.P. van der, Spek, A van der, Wielen, N. van der, Duyn, E. van, Eekelen, C. van, Essen, J.A. van, Gangelt, K. van, Geloven, A.A. van, Kessel, C. Van, Loon, Y.T. van, Rijswijk, A. van, Rooijen, S.J. van, Sprundel, T. van, Steensel, L. van, Tets, W.F van, Westreenen, H.L. van, Veltkamp, S., Verhaak, T., Verheijen, P.M., Versluis-Ossenwaarde, L., Vijfhuize, S., Vles, W.J., Voeten, S., Vogelaar, F.J., Vrijland, W.W., Westerduin, E., Westerterp, M., Wetzel, M., Wevers, K., Wiering, B., Witjes, A.C., Wouters, M.W., Yauw, S.T.K., Zeestraten, E.C., Zimmerman, D., Zwieten, T., Groningen Institute for Organ Transplantation (GIOT), Value, Affordability and Sustainability (VALUE), ​Robotics and image-guided minimally-invasive surgery (ROBOTICS), Surgery, CCA - Cancer Treatment and quality of life, APH - Quality of Care, APH - Global Health, Anatomy and neurosciences, VU University medical center, AGEM - Re-generation and cancer of the digestive system, AGEM - Digestive immunity, Neurology, Internal medicine, ACS - Microcirculation, MUMC+: MA Heelkunde (9), RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, Promovendi MHN, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: NUTRIM - R1 - Metabolic Syndrome, RS: NUTRIM - R2 - Liver and digestive health, Revalidatie, RS: CARIM - R1.03 - Cell biochemistry of thrombosis and haemostasis, Biochemie, Promovendi CD, Ondersteunend personeel NTM, Promovendi NTM, Promovendi PHPC, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, MUMC+: MA AIOS Heelkunde (9), Promovendi ODB, MUMC+: MA AIOS Anesthesiologie (9), Pathologie, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA - Cancer Treatment and Quality of Life, Graduate School, and Other departments

Subjects
Male, Transanal Endoscopic Microsurgery, Colorectal cancer, medicine.medical_treatment, NETHERLANDS, law.invention, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, ADJUVANT CHEMOTHERAPY, Randomized controlled trial, law, Interquartile range, Prospective Studies, Registries, Rectal cancer, Intersectoral Collaboration, Randomized Controlled Trials as Topic, Aged, 80 and over, Medical Audit, Gastroenterology, Margins of Excision, Chemoradiotherapy, Benchmarking, Middle Aged, Total mesorectal excision, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Treatment Outcome, snapshot study, 030220 oncology & carcinogenesis, OPEN SURGERY, Cohort, Female, 030211 gastroenterology & hepatology, RADIOTHERAPY, medicine.medical_specialty, Disease-Free Survival, 03 medical and health sciences, ANTERIOR RESECTION, medicine, Humans, Aged, Retrospective Studies, oncologic outcomes, Rectal Neoplasms, business.industry, General surgery, TOTAL MESORECTAL EXCISION, medicine.disease, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Radiation therapy, Cross-Sectional Studies, Circumferential resection margin, Neoplasm Recurrence, Local, business
Abstract

Aim A Snapshot study design eliminates changes in treatment and outcome over time. This population based Snapshot study aimed to determine current practice and outcome of rectal cancer treatment with published landmark randomized controlled trials as a benchmark.Method In this collaborative research project, the dataset of the Dutch Surgical Colorectal Audit was extended with additional treatment and long-term outcome data. All registered patients who underwent resection for rectal cancer in 2011 were eligible. Baseline characteristics and outcome were evaluated against the results of the Dutch TME trial and the COLOR II trial from which the original datasets were obtained.Results A total of 71 hospitals participated, and data were completed for 2102 out of the potential 2633 patients (79.8%). Median follow-up was 41 (interquartile range 25-47) months. Overall circumferential resection margin (CRM) involvement was 9.3% in the Snapshot cohort and 18.5% in the Dutch TME trial. CRM positivity after laparoscopic resection was 7.8% in the Snapshot and 9.5% in the COLOR II trial. Three-year overall local recurrence rate in the Snapshot was 5.9%, with a disease-free survival of 67.1% and overall survival of 79.5%. Benchmarking with the randomized controlled trials revealed an overall favourable long-term outcome of the Snapshot cohort.Conclusion This study showed that current rectal cancer care in a large unselected Dutch population is of high quality, with less positive CRM since the TME trial and oncologically safe implementation of minimally invasive surgery after the COLOR II trial.

Published
2017
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73. Minimally invasive versus open distal pancreatectomy (LEOPARD): study protocol for a randomized controlled trial

Author

Rooij, T. de, Hilst, J. van, Vogel, J.A., Santvoort, H.C. van, Boer, M.T. de, Boerma, D., Boezem, P.B. van den, Bonsing, B.A., Bosscha, K., Coene, P.P., Daams, F., Dam, R.M. van, Dijkgraaf, M.G., Eijck, C.H. van, Festen, S., Gerhards, M.F., Koerkamp, B.G., Hagendoorn, J., Harst, E. van der, Hingh, I.H. de, Dejong, C.H., Kazemier, G., Klaase, J., Kleine, R.H. de, Laarhoven, C.J. van, Lips, D.J., Luyer, M.D., Molenaar, I.Q., Nieuwenhuijs, V.B., Patijn, G.A., Roos, D., Scheepers, J.J., Schelling, G.P. van der, Steenvoorde, P., Swijnenburg, R.J., Wijsman, J.H., Abu Hilal, M., Busch, O.R., Besselink, M.G., Dutch Pancreatic Canc Grp, CCA - Cancer Treatment and quality of life, AGEM - Re-generation and cancer of the digestive system, Surgery, Groningen Institute for Organ Transplantation (GIOT), Value, Affordability and Sustainability (VALUE), RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Gut-liver homeostasis, CCA - Cancer Treatment and Quality of Life, Other departments, APH - Methodology, Clinical Research Unit, and Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
Time Factors, medicine.medical_treatment, Cost-Benefit Analysis, Health Status, INTERNATIONAL STUDY-GROUP, Distal pancreatectomy, Medicine (miscellaneous), Administration, Oral, law.invention, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Study Protocol, Eating, 0302 clinical medicine, Superiority Trial, Randomized controlled trial, Quality of life, Clinical Protocols, Robotic Surgical Procedures, law, SURGERY ISGPS, Pharmacology (medical), 030212 general & internal medicine, Hospital Costs, Laparoscopy, Netherlands, Pain Measurement, Analgesics, Pain, Postoperative, lcsh:R5-920, medicine.diagnostic_test, MALIGNANT-DISEASE, Robot-assisted, 3. Good health, Treatment Outcome, Research Design, 030220 oncology & carcinogenesis, Pancreatectomy, lcsh:Medicine (General), Cohort study, medicine.medical_specialty, LONG-TERM, BENIGN, Pancreatic surgery, DUCTAL ADENOCARCINOMA, PANCREATOSPLENECTOMY, CLINICAL-TRIAL, 03 medical and health sciences, Laparoscopic, medicine, Journal Article, Humans, IDEAL FRAMEWORK, Minimally invasive, business.industry, Recovery of Function, Pancreatic cancer, Surgery, Clinical trial, DEFINITION, Quality of Life, Observational study, business, Energy Intake
Abstract

Background Observational cohort studies have suggested that minimally invasive distal pancreatectomy (MIDP) is associated with better short-term outcomes compared with open distal pancreatectomy (ODP), such as less intraoperative blood loss, lower morbidity, shorter length of hospital stay, and reduced total costs. Confounding by indication has probably influenced these findings, given that case-matched studies failed to confirm the superiority of MIDP. This accentuates the need for multicenter randomized controlled trials, which are currently lacking. We hypothesize that time to functional recovery is shorter after MIDP compared with ODP even in an enhanced recovery setting. Methods LEOPARD is a randomized controlled, parallel-group, patient-blinded, multicenter, superiority trial in all 17 centers of the Dutch Pancreatic Cancer Group. A total of 102 patients with symptomatic benign, premalignant or malignant disease will be randomly allocated to undergo MIDP or ODP in an enhanced recovery setting. The primary outcome is time (days) to functional recovery, defined as all of the following: independently mobile at the preoperative level, sufficient pain control with oral medication alone, ability to maintain sufficient (i.e. >50%) daily required caloric intake, no intravenous fluid administration and no signs of infection. Secondary outcomes are operative and postoperative outcomes, including clinically relevant complications, mortality, quality of life and costs. Discussion The LEOPARD trial is designed to investigate whether MIDP reduces the time to functional recovery compared with ODP in an enhanced recovery setting. Trial registration Dutch Trial Register, NTR5188. Registered on 9 April 2015 Electronic supplementary material The online version of this article (doi:10.1186/s13063-017-1892-9) contains supplementary material, which is available to authorized users.

Published
2017
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74. Variation in hospital mortality after pancreatoduodenectomy is related to failure to rescue rather than major complications: a nationwide audit

Author

van Rijssen, L., primary, Zwart, M., additional, Van Dieren, S., additional, De Rooij, T., additional, Bonsing, B., additional, Bosscha, K., additional, van Dam, R., additional, Van Eijck, C., additional, Gerhards, M., additional, Gerritsen, J., additional, Van Der Harst, E., additional, De Hingh, I., additional, De Jong, K., additional, Kazemier, G., additional, Klaase, J., additional, Van Der Kolk, M., additional, van Laarhoven, C., additional, Luyer, M., additional, Molenaar, I., additional, Patijn, G., additional, Rupert, C., additional, Scheepers, J., additional, Van Der Schelling, G., additional, Vahrmeijer, A., additional, Busch, O., additional, Van Santvoort, H., additional, Groot Koerkamp, B., additional, and Besselink, M., additional

Published
2019
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75. Intraoperative Fistula Risk Score (iFRS) In Pancreatoduodenectomy: Development and Validation in Three Datasets

Author

Mungroop, T., primary, van Rijssen, L.B., additional, van Klaveren, D., additional, Smits, F.J., additional, van Woerden, V., additional, Linnemann, R., additional, Ecker, B.L., additional, van Dieren, S., additional, Bonsing, B., additional, Busch, O., additional, van Dam, R., additional, Erdmann, J., additional, van Eijck, C., additional, Gerhards, M., additional, van Goor, H., additional, van der Harst, E., additional, de Hingh, I., additional, de Jong, K., additional, Kazemier, G., additional, Luyer, M., additional, Shamali, A., additional, Barbaro, S., additional, Armstrong, T., additional, Takhar, A., additional, Hamady, Z., additional, Klaase, J., additional, Lips, D., additional, Molenaar, I.Q., additional, Nieuwenhuis, V., additional, Rupert, C., additional, van Santvoort, H., additional, Scheepers, J., additional, van der Schelling, G., additional, Vollmer, C., additional, Steyerberg, E., additional, Abu Hilal, M., additional, Groot Koerkamp, B., additional, and Besselink, M., additional

Published
2019
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76. Nationwide prospective audit of pancreatic surgery: design, accuracy, and outcomes of the Dutch Pancreatic Cancer Audit

Author

van Rijssen, L., primary, Groot Koerkamp, B., additional, Zwart, M., additional, Bonsing, B., additional, Bosscha, K., additional, van Dam, R., additional, Van Eijck, C., additional, Gerhards, M., additional, Van Der Harst, E., additional, De Hingh, I., additional, De Jong, K., additional, Kazemier, G., additional, Klaase, J., additional, van Laarhoven, C., additional, Molenaar, I., additional, Patijn, G., additional, Rupert, C., additional, Van Santvoort, H., additional, Scheepers, J., additional, Van Der Schelling, G., additional, Busch, O., additional, and Besselink, M., additional

Published
2019
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80. Variation in hospital mortality after pancreatoduodenectomy is related to failure to rescue rather than major complications: a nationwide audit

Author

Rijssen, L.B. van, Zwart, M.J., Dieren, S. van, Rooij, T. de, Bonsing, B.A., Bosscha, K., Dam, R.M. van, Eijck, C.H. van, Gerhards, M.F., Gerritsen, J.J., Harst, E, Hingh, I.H. de, Jong, K.P. de, Kazemier, G., Klaase, J., Kolk, B.M. van der, Laarhoven, C.J.H.M. van, Luyer, M.D., Molenaar, I.Q., Patijn, G.A., Rupert, C.G., Scheepers, J.J., Schelling, G.P. van der, Vahrmeijer, A.L., Busch, O.R., Santvoort, H.C. van, Koerkamp, B. Groot, Besselink, M.G.H., Rijssen, L.B. van, Zwart, M.J., Dieren, S. van, Rooij, T. de, Bonsing, B.A., Bosscha, K., Dam, R.M. van, Eijck, C.H. van, Gerhards, M.F., Gerritsen, J.J., Harst, E, Hingh, I.H. de, Jong, K.P. de, Kazemier, G., Klaase, J., Kolk, B.M. van der, Laarhoven, C.J.H.M. van, Luyer, M.D., Molenaar, I.Q., Patijn, G.A., Rupert, C.G., Scheepers, J.J., Schelling, G.P. van der, Vahrmeijer, A.L., Busch, O.R., Santvoort, H.C. van, Koerkamp, B. Groot, and Besselink, M.G.H.

Abstract

Item does not contain fulltext, BACKGROUND: In the mandatory nationwide Dutch Pancreatic Cancer Audit, rates of major complications and Failure to Rescue (FTR) after pancreatoduodenectomy between low- and high-mortality hospitals are compared, and independent predictors for FTR investigated. METHODS: Patients undergoing pancreatoduodenectomy in 2014 and 2015 in The Netherlands were included. Hospitals were divided into quartiles based on mortality rates. The rate of major complications (Clavien-Dindo >/=3) and death after a major complication (FTR) were compared between these quartiles. Independent predictors for FTR were identified by multivariable logistic regression analysis. RESULTS: Out of 1.342 patients, 391 (29%) developed a major complication and in-hospital mortality was 4.2%. FTR occurred in 56 (14.3%) patients. Mortality was 0.9% in the first hospital quartile (4 hospitals, 327 patients) and 8.1% in the fourth quartile (5 hospitals, 310 patients). The rate of major complications increased by 40% (25.7% vs 35.2%) between the first and fourth hospital quartile, whereas the FTR rate increased by 560% (3.6% vs 22.9%). Independent predictors of FTR were male sex (OR = 2.1, 95%CI 1.2-3.9), age >75 years (OR = 4.3, 1.8-10.2), BMI >/=30 (OR = 2.9, 1.3-6.6), histopathological diagnosis of periampullary cancer (OR = 2.0, 1.1-3.7), and hospital volume <30 (OR = 3.9, 1.6-9.6). CONCLUSIONS: Variations in mortality between hospitals after pancreatoduodenectomy were explained mainly by differences in FTR, rather than the incidence of major complications.

Published
2018

82. Magnetic technique for sentinel lymph node biopsy in melanoma: the MELAMAG trial

Author

Anninga, B, White, S, Moncrieff, M, Dziewulski, P, Geh, J, Klaase, J, Garmo, H, Castro, F, Pinder, S, Pankhurst, Q, Hall-Craggs, M, Douek, M, and Group, MELAMAG Multicentre Trialists

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Sentinel lymph node, 030230 surgery, 03 medical and health sciences, 0302 clinical medicine, Biopsy, medicine, Humans, Coloring Agents, Lymph node, Melanoma, Aged, medicine.diagnostic_test, business.industry, Sentinel Lymph Node Biopsy, International Agencies, Sentinel node, Middle Aged, equipment and supplies, medicine.disease, Prognosis, Surgery, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Cutaneous melanoma, Magnets, Feasibility Studies, Lymphadenectomy, Female, Sentinel Lymph Node, Nuclear medicine, business, human activities, Gamma probe, Follow-Up Studies
Abstract

Background: Sentinel lymph node biopsy (SLNB) in melanoma is currently performed using the standard dual technique (radioisotope and blue dye). The magnetic technique is non-radioactive and provides a brown color change in the sentinel lymph node (SLN) through an intradermal injection of a magnetic tracer, and utilizes a handheld magnetometer. The MELAMAG Trial compared the magnetic technique with the standard technique for SLNB in melanoma. Methods: Clinically node-negative patients with primary cutaneous melanoma were recruited from four centers. SLNB was undertaken after intradermal administration of both the standard (blue dye and radioisotope) and magnetic tracers. The SLN identification rate per patient, with the two techniques, was compared. Results: A total of 133 patients were recruited, 129 of which were available for final analysis. The sentinel node identification rate was 97.7 % (126/129) with the standard technique and 95.3 % (123/129) with the magnetic technique [2.3 % difference; 95 % upper confidence limit (CL) 6.4; 5.4 % discordance]. With radioisotope alone, the SLN identification rate was 95.3 % (123/129), as with the magnetic technique (0 % difference; 95 % upper CL 4.5; 7.8 % discordance). The lymph node retrieval rate was 1.99 nodes per patient overall, 1.78 with the standard technique and 1.87 with the magnetic technique. Conclusions: The magnetic technique is feasible for SLNB in melanoma with a high SLN identification rate, but is associated with skin staining. When compared with the standard dual technique, it did not reach our predefined non-inferiority margin.

Published
2016

85. Nationwide prospective audit of pancreatic surgery: design, accuracy, and outcomes of the Dutch Pancreatic Cancer Audit

Author

Rijssen, L.B. van, Koerkamp, B.G., Zwart, M.J., Bonsing, B.A., Bosscha, K., Dam, R.M. van, Eijck, C.H. van, Gerhards, M.F., Harst, E. van der, Hingh, I.H. de, Jong, K.P. de, Kazemier, G., Klaase, J., Laarhoven, C.J.H.M. van, Molenaar, I.Q., Patijn, G.A., Rupert, C.G., Santvoort, H.C. van, Scheepers, J.J., Schelling, G.P. van der, Busch, O.R., Besselink, M.G., Rijssen, L.B. van, Koerkamp, B.G., Zwart, M.J., Bonsing, B.A., Bosscha, K., Dam, R.M. van, Eijck, C.H. van, Gerhards, M.F., Harst, E. van der, Hingh, I.H. de, Jong, K.P. de, Kazemier, G., Klaase, J., Laarhoven, C.J.H.M. van, Molenaar, I.Q., Patijn, G.A., Rupert, C.G., Santvoort, H.C. van, Scheepers, J.J., Schelling, G.P. van der, Busch, O.R., and Besselink, M.G.

Abstract

Item does not contain fulltext, BACKGROUND: Auditing is an important tool to identify practice variation and 'best practices'. The Dutch Pancreatic Cancer Audit is mandatory in all 18 Dutch centers for pancreatic surgery. METHODS: Performance indicators and case-mix factors were identified by a PubMed search for randomized controlled trials (RCT's) and large series in pancreatic surgery. In addition, data dictionaries of two national audits, three institutional databases, and the Dutch national cancer registry were evaluated. Morbidity, mortality, and length of stay were analyzed of all pancreatic resections registered during the first two audit years. Case ascertainment was cross-checked with the Dutch healthcare inspectorate and key-variables validated in all centers. RESULTS: Sixteen RCT's and three large series were found. Sixteen indicators and 20 case-mix factors were included in the audit. During 2014-2015, 1785 pancreatic resections were registered including 1345 pancreatoduodenectomies. Overall in-hospital mortality was 3.6%. Following pancreatoduodenectomy, mortality was 4.1%, Clavien-Dindo grade >/= III morbidity was 29.9%, median (IQR) length of stay 12 (9-18) days, and readmission rate 16.0%. In total 97.2% of >40,000 variables validated were consistent with the medical charts. CONCLUSIONS: The Dutch Pancreatic Cancer Audit, with high quality data, reports good outcomes of pancreatic surgery on a national level.

Published
2017

86. Minimally invasive versus open distal pancreatectomy (LEOPARD): study protocol for a randomized controlled trial

Author

de Rooij, T, van Hilst, J, Vogel, J A, van Santvoort, HC, de Boer, MT, Boerma, D, van den Boezem, PB, Bonsing, BA, Bosscha, K, Coene, PP, Daams, F, van Dam, RM, Dijkgraaf, MG, van Eijck, Casper, Festen, S, Gerhards, MF, Groot Koerkamp, B, Hagendoorn, J, van der Harst, E, de Hingh, IH, DeJong, CH, Kazemier, G, Klaase, J, de Kleine, R H, van Laarhoven, CJ, Lips, DJ, Luyer, MD, Molenaar, IQ, Nieuwenhuijs, VB, Patijn, GA, Roos, D, Scheepers, JJ, van der Schelling, GP, Steenvoorde, P, Swijnenburg, RJ, Wijsman, JH, Abu Hilal, M, Busch, OR, Besselink, MG, de Rooij, T, van Hilst, J, Vogel, J A, van Santvoort, HC, de Boer, MT, Boerma, D, van den Boezem, PB, Bonsing, BA, Bosscha, K, Coene, PP, Daams, F, van Dam, RM, Dijkgraaf, MG, van Eijck, Casper, Festen, S, Gerhards, MF, Groot Koerkamp, B, Hagendoorn, J, van der Harst, E, de Hingh, IH, DeJong, CH, Kazemier, G, Klaase, J, de Kleine, R H, van Laarhoven, CJ, Lips, DJ, Luyer, MD, Molenaar, IQ, Nieuwenhuijs, VB, Patijn, GA, Roos, D, Scheepers, JJ, van der Schelling, GP, Steenvoorde, P, Swijnenburg, RJ, Wijsman, JH, Abu Hilal, M, Busch, OR, and Besselink, MG

Published
2017

87. Randomized clinical trial of open versus laparoscopic left lateral hepatic sectionectomy within an enhanced recovery after surgery programme (ORANGE II study)

Author

Wong-Lun-Hing, E M, primary, van Dam, R M, additional, van Breukelen, G J P, additional, Tanis, P J, additional, Ratti, F, additional, van Hillegersberg, R, additional, Slooter, G D, additional, de Wilt, J H W, additional, Liem, M S L, additional, de Boer, M T, additional, Klaase, J M, additional, Neumann, U P, additional, Aldrighetti, L A, additional, Dejong, C H C, additional, Terkivatan, T, additional, Verhoef, C, additional, Porte, R J, additional, Haverman, J W, additional, Busch, O R, additional, Boermeester, M A, additional, Besselink, M G, additional, Molenaar, I Q, additional, Borel Rinkes, I H M, additional, Bosscha, K, additional, van der Vorst, J R, additional, de Waard, J W D, additional, Gerhards, M F, additional, Patijn, G A, additional, Schmeding, M, additional, Primrose, J N, additional, Abu Hilal, M, additional, Dagher, I, additional, Laurent, A, additional, Topal, B, additional, Edwin, B, additional, Lassen, K, additional, van Duyn, E B, additional, Ambergen, A W, additional, Olde Damink, S W, additional, and Bemelmans, M H, additional

Published
2017
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88. Impact of a Nationwide Training Program in Minimally Invasive Distal Pancreatectomy (LAELAPS)

Author

Rooij, T. de, Hilst, J. van, Boerma, D., Bonsing, B.A., Daams, F., Dam, R.M. van, Dijkgraaf, M.G., Eijck, C.H. van, Festen, S., Gerhards, M.F., Koerkamp, B.G., Harst, E. van der, Hingh, I.H. de, Kazemier, G., Klaase, J., Kleine, R.H. de, Laarhoven, C.J.H.M. van, Lips, D.J., Luyer, M.D., Molenaar, I.Q., Patijn, G.A., Roos, D., Scheepers, J.J., Schelling, G.P. van der, Steenvoorde, P., Vriens, M.R., Wijsman, J.H., Gouma, D.J., Busch, O.R., Hilal, M.A., Besselink, M.G., Rooij, T. de, Hilst, J. van, Boerma, D., Bonsing, B.A., Daams, F., Dam, R.M. van, Dijkgraaf, M.G., Eijck, C.H. van, Festen, S., Gerhards, M.F., Koerkamp, B.G., Harst, E. van der, Hingh, I.H. de, Kazemier, G., Klaase, J., Kleine, R.H. de, Laarhoven, C.J.H.M. van, Lips, D.J., Luyer, M.D., Molenaar, I.Q., Patijn, G.A., Roos, D., Scheepers, J.J., Schelling, G.P. van der, Steenvoorde, P., Vriens, M.R., Wijsman, J.H., Gouma, D.J., Busch, O.R., Hilal, M.A., and Besselink, M.G.

Abstract

Item does not contain fulltext, OBJECTIVE: To study the feasibility and impact of a nationwide training program in minimally invasive distal pancreatectomy (MIDP). SUMMARY OF BACKGROUND DATA: Superior outcomes of MIDP compared with open distal pancreatectomy have been reported. In the Netherlands (2005 to 2013) only 10% of distal pancreatectomies were in a minimally invasive fashion and 85% of surgeons welcomed MIDP training. The feasibility and impact of a nationwide training program is unknown. METHODS: From 2014 to 2015, 32 pancreatic surgeons from 17 centers participated in a nationwide training program in MIDP, including detailed technique description, video training, and proctoring on-site. Outcomes of MIDP before training (2005-2013) were compared with outcomes after training (2014-2015). RESULTS: In total, 201 patients were included; 71 underwent MIDP in 9 years before training versus 130 in 22 months after training (7-fold increase, P < 0.001). The conversion rate (38% [n = 27] vs 8% [n = 11], P < 0.001) and blood loss were lower after training and more pancreatic adenocarcinomas were resected (7 [10%] vs 28 [22%], P = 0.03), with comparable R0-resection rates (4/7 [57%] vs 19/28 [68%], P = 0.67). Clavien-Dindo score >/=III complications (15 [21%] vs 19 [15%], P = 0.24) and pancreatic fistulas (20 [28%] vs 41 [32%], P = 0.62) were not significantly different. Length of hospital stay was shorter after training (9 [7-12] vs 7 [5-8] days, P < 0.001). Thirty-day mortality was 3% vs 0% (P = 0.12). CONCLUSION: A nationwide MIDP training program was feasible and followed by a steep increase in the use of MIDP, also in patients with pancreatic cancer, and decreased conversion rates. Future studies should determine whether such a training program is applicable in other settings.

Published
2016

94. Outcome and survival after distal pancreatectomy for pancreatic ductal adenocarcinoma: a nationwide cohort study

Author

De Rooij, T., primary, Tol, J., additional, Van Eijck, C., additional, Boerma, D., additional, Bonsing, B., additional, Bosscha, K., additional, Van Dam, R., additional, Dijkgraaf, M., additional, Gerhards, M., additional, Van Goor, H., additional, Van Der Harst, E., additional, De Hingh, I., additional, Kazemier, G., additional, Klaase, J., additional, Molenaar, Q., additional, Patijn, G., additional, Van Santvoort, H., additional, Scheepers, J., additional, Van Der Schelling, G., additional, Sieders, E., additional, Busch, O., additional, and Besselink, M., additional

Published
2016
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95. Open versus laparoscopic left lateral hepatic sectionectomy within an enhanced recovery ERAS® programme (ORANGE II-trial): study protocol for a randomised controlled trial

Author

Van Dam, Ronald M., Wong-Lun-Hing, Edgar M., Van Breukelen, Gerard J. P., Stoot, Jan H. M. B., Van Der Vorst, Joost R., Bemelmans, Marc H. A., Olde Damink, Steven W. M., Lassen, Kristoffer, Dejong, Cornelis H. C., ORANGE II Study Group, Busch, O. R., Tanis, P. J., Hoekstra, L. T., Van Hillegersberg, R., Molenaar, I. Q., Verhoef, C., Terkivatan, T., De Jonge, J., Slooter, G. D., Roumen, R. M., Klaase, J. M., Van Duyn, E. B., Boscha, K., Porte, R. J., De Boer, M. T., Haveman, J. W., De Wilt, J. H., Buyne, O. R., Van Duijvendijk, P., Neumann, U., Schmeding, M., Ferla, G., Aldrighetti, L. A., Ferla, F., Primrose, J. N., Abu Hilal, M., Pearce, N. W., Dagher, I., Laurent, A., Topal, B., Troisi, R. I., Edwin, B., Boermeester, M. A., Borel Rinkes, I. H., Ambergen, A. W., AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA -Cancer Center Amsterdam, Surgery, AII - Amsterdam institute for Infection and Immunity, RS: CAPHRI School for Public Health and Primary Care, RS: NUTRIM - R2 - Gut-liver homeostasis, RS: FPN M&S I, FHML Methodologie & Statistiek, Dean and Directors Office, van Dam Ronald, M., Wong-Lun-Hing Edgar, M., Van Breukelen Gerard, J. P., Stoot Jan, H. M. B., van der Vorst Joost, R., Bemelmans Marc, H. A., Damink Steven W. M., Olde, Lassen, Kristoffer, Dejong Cornelis, H. C., and Aldrighetti, L

Subjects
Laparoscopic surgery, Time Factors, EARLY AMBULATION, medicine.medical_treatment, Medicine (miscellaneous), law.invention, Study Protocol, Quality of life, Randomized controlled trial, QUALITY-OF-LIFE, law, Left lateral sectionectomy, Clinical endpoint, Outpatient clinic, INCISIONAL HERNIA, Pharmacology (medical), Prospective Studies, Registries, ERAS, Hospital Costs, Prospective cohort study, lcsh:R5-920, PARTIAL-HEPATECTOMY, Hernia, Abdominal, INTESTINAL RESECTION, Europe, Treatment Outcome, COLONIC RESECTION, Patient Satisfaction, Research Design, Evaluation of complex medical interventions Tissue engineering and pathology [NCEBP 2], lcsh:Medicine (General), CLINICAL-TRIALS, RCT, medicine.medical_specialty, CONTROLLED REHABILITATION, Quality of Care [ONCOL 4], Cicatrix, Double-Blind Method, Body Image, medicine, Humans, Hepatectomy, Hernia, Open liver resection, business.industry, Recovery of Function, Length of Stay, medicine.disease, Surgery, COLORECTAL LIVER METASTASES, Clinical trial, NUMERIC RATING-SCALE, Quality of Life, Laparoscopy, business
Abstract

Trials 13, 54 (2012). doi:10.1186/1745-6215-13-54, Published by BioMed Central, London

Published
2012
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96. Intensified follow-up in colorectal cancer patients using frequent Carcino-Embryonic Antigen (CEA) measurements and CEA-triggered imaging: results of the randomized 'CEAwatch' trial

Author

Verberne, C. J., Zhan, Z., van den Heuvel, E.R., Grossmann, I.E., Doornbos, P.M., Havenga, K., Manusama, E., Klaase, J., Van Der Mijle, H.C.J., Lamme, B., Bosscha, K., Baas, P., Van Ooijen, B., Nieuwenhuijzen, G., Marinelli, A., Van Der Zaag, E., Wasowicz, D., De Bock, G. H., Wiggers, T., Verberne, C. J., Zhan, Z., van den Heuvel, E.R., Grossmann, I.E., Doornbos, P.M., Havenga, K., Manusama, E., Klaase, J., Van Der Mijle, H.C.J., Lamme, B., Bosscha, K., Baas, P., Van Ooijen, B., Nieuwenhuijzen, G., Marinelli, A., Van Der Zaag, E., Wasowicz, D., De Bock, G. H., and Wiggers, T.

Abstract

Abstract Aim The value of frequent Carcino-Embryonic Antigen (CEA) measurements and CEA-triggered imaging for detecting recurrent disease in colorectal cancer (CRC) patients was investigated in search for an evidence-based follow-up protocol. Methods This is a randomized-controlled multicenter prospective study using a stepped-wedge cluster design. From October 2010 to October 2012, surgically treated non-metastasized CRC patients in follow-up were followed in eleven hospitals. Clusters of hospitals sequentially changed their usual follow-up care into an intensified follow-up schedule consisting of CEA measurements every two months, with imaging in case of two CEA rises. The primary outcome measures were the proportion of recurrences that could be treated with curative intent, recurrences with definitive curative treatment outcome, and the time to detection of recurrent disease. Results 3223 patients were included; 243 recurrences were detected (7.5%). A higher proportion of recurrences was detected in the intervention protocol compared to the control protocol (OR = 1.80; 95%-CI: 1.33-2.50; p = 0.0004). The proportion of recurrences that could be treated with curative intent was higher in the intervention protocol (OR = 2.84; 95%-CI: 1.38-5.86; p = 0.0048) and the proportion of recurrences with definitive curative treatment outcome was also higher (OR = 3.12, 95%-CI: 1.25-6.02, p-value: 0.0145). The time to detection of recurrent disease was significantly shorter in the intensified follow-up protocol (HR = 1.45; 95%-CI: 1.08-1.95; p = 0.013). Conclusion The CEAwatch protocol detects recurrent disease after colorectal cancer earlier, in a phase that a significantly higher proportion of recurrences can be treated with curative intent.

Published
2015

98. Prospective nationwide outcome audit of surgery for suspected acute appendicitis

Author

van Rossem, C C, primary, Bolmers, M D M, additional, Schreinemacher, M H F, additional, van Geloven, A A W, additional, Bemelman, W A, additional, Acker, G J D, additional, Akkermans, B, additional, Akkersdijk, G J M, additional, Algie, G D, additional, Allema, J H, additional, Andeweg, C S, additional, Appeldorn, N, additional, Baal, J G, additional, Bakker, C M, additional, Bartels, S A L, additional, Berg, C, additional, Boekestijn, B, additional, Boer, F C, additional, Boerma, D, additional, Boom, A L, additional, Boute, M C, additional, Bouwense, S A W, additional, Bransen, J, additional, Brussel, F A, additional, Busch, O R C, additional, Castro, S M M, additional, Cense, H A, additional, Croese, C, additional, Dalen, T, additional, Dawson, I, additional, Dessel, E, additional, Dettmers, R, additional, Dhar, N, additional, Dohmen, F Y M, additional, Dongen, K W, additional, Duijvendijk, P, additional, Dulfer, R R, additional, Dwars, B J, additional, Eerenberg, J P, additional, Elst, M, additional, Ende, E, additional, Fassaert, L M M, additional, Fikkers, J T, additional, Foppen, J W, additional, Furnee, E J B, additional, Garssen, F P, additional, Gerhards, M F, additional, Goor, H, additional, Gorter, R R, additional, Graaf, J S, additional, Graat, L J, additional, Groote, J, additional, Ham, A C, additional, Hamming, J F, additional, Hamminga, J T H, additional, Harst, E, additional, Heemskerk, J, additional, Heij, H A, additional, Heijne, A, additional, Heikens, J T, additional, Heineman, E, additional, Hertogs, R, additional, Heurn, E, additional, Hil, L C L, additional, Hoofwijk, A G M, additional, Hulsker, C C C, additional, Hunen, D R M, additional, Ibelings, M S, additional, Klaase, J M, additional, Klicks, R, additional, Knaapen, L, additional, Kortekaas, R T J, additional, Kruyt, F, additional, Kwant, S, additional, Lases, S S, additional, Lettinga, T, additional, Loupatty, A, additional, Matthijsen, R A, additional, Minnee, R C, additional, Mirck, B, additional, Mitalas, L, additional, Moes, D, additional, Moorman, A M, additional, Nieuwenhuijs, V B, additional, Nieuwenhuijzen, G A P, additional, Nijk, P D, additional, Omloo, J M T, additional, Ottenhof, A G, additional, Palamba, H W, additional, Peet, D L, additional, Pereboom, I T A, additional, Plaisier, P W, additional, Ploeg, A P T, additional, Raber, M H, additional, Reijnen, M M P J, additional, Rijna, H, additional, Rosman, C, additional, Roumen, R M H, additional, Schmitz, R F, additional, Velden, A P Schouten, additional, Schreurs, W H, additional, Sigterman, T A, additional, Smeets, H J, additional, Sonneveld, D J A, additional, Sosef, M N, additional, Spoor, S F, additional, Stassen, L P S, additional, Steensel, L, additional, Stortelder, E, additional, Straatman, J, additional, Susante, H J, additional, Hoog, D E N M Suykerbuyk, additional, Scheltinga, C Terwisscha, additional, Toorenvliet, B R, additional, Verbeek, B M, additional, Verbeek, P C M, additional, Verseveld, M, additional, Volders, J H, additional, Vriens, M R, additional, Vriens, P W H E, additional, Vrouenraets, B C, additional, Wall, B J M, additional, Wegdam, J A, additional, Westerduin, E, additional, Wever, J J, additional, Wijffels, N A T, additional, Wijnhoven, B P L, additional, Winkel, T A, additional, Zee, D C, additional, Zeillemaker, A M, additional, and Zietse, C, additional

Published
2015
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99. Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial

Author

Vennix, Sandra, primary, Musters, Gijsbert D, additional, Mulder, Irene M, additional, Swank, Hilko A, additional, Consten, Esther C, additional, Belgers, Eric H, additional, van Geloven, Anna A, additional, Gerhards, Michael F, additional, Govaert, Marc J, additional, van Grevenstein, Wilhelmina M, additional, Hoofwijk, Anton G, additional, Kruyt, Philip M, additional, Nienhuijs, Simon W, additional, Boermeester, Marja A, additional, Vermeulen, Jefrey, additional, van Dieren, Susan, additional, Lange, Johan F, additional, Bemelman, Willem A, additional, Hop, W C, additional, Opmeer, B C, additional, Reitsma, J B, additional, Scholte, R A, additional, Waltmann, E W H, additional, Legemate, D A, additional, Bartelsman, J F, additional, Meijer, D W, additional, de Brouwer, M, additional, van Dalen, J, additional, Durbridge, M, additional, Geerdink, M, additional, Ilbrink, G J, additional, Mehmedovic, S, additional, Middelhoek, P, additional, Di Saverio, Salomone, additional, Boom, M J, additional, Consten, E C J, additional, van der Bilt, J D W, additional, van Olden, G D J, additional, Stam, M A W, additional, Verweij, M S, additional, Busch, O R C, additional, Buskens, C J, additional, El-Massoudi, Y, additional, Kluit, A B, additional, van Rossem, C C, additional, Schijven, M P, additional, Tanis, P J, additional, Unlu, C, additional, Gerhards, M F, additional, Karsten, T M, additional, de Nes, L C, additional, Rijna, H, additional, van Wagensveld, B A, additional, Koffeman, G I, additional, Steller, E P, additional, Tuynman, J B, additional, Bruin, S C, additional, van der Peet, D L, additional, Blanken-Peeters, C F J M, additional, Cense, H A, additional, Jutte, E, additional, Crolla, R M P H, additional, van der Schelling, G P, additional, van Zeeland, M, additional, de Graaf, E J R, additional, Groenendijk, R P R, additional, Vermaas, M, additional, Schouten, O, additional, de Vries, M R, additional, Prins, H A, additional, Lips, D J, additional, Bosker, R J I, additional, van der Hoeven, J A B, additional, Diks, J, additional, Plaisier, P W, additional, Kruyt, P M, additional, Sietses, C, additional, Stommel, M W J, additional, Nienhuijs, S W, additional, de Hingh, I H J T, additional, Luyer, M D P, additional, van Montfort, G, additional, Ponten, E H, additional, Smulders, J F, additional, van Duyn, E B, additional, Klaase, J M, additional, Swank, D J, additional, Ottow, R T, additional, Stockmann, H B A C, additional, Vermeulen, J, additional, Vuylsteke, R J C L M, additional, Belgers, H J, additional, Fransen, S, additional, von Meijenfeldt, E M, additional, Sosef, M N, additional, van Geloven, A A W, additional, Hendriks, E R, additional, ter Horst, B, additional, Leeuwenburgh, M M N, additional, van Ruler, O, additional, Vogten, J M, additional, Vriens, E J C, additional, Westerterp, M, additional, Eijsbouts, Q A J, additional, Bentohami, A, additional, Bijlsma, T S, additional, de Korte, N, additional, Nio, D, additional, Govaert, M J P M, additional, Joosten, J J A, additional, Tollenaar, R A E M, additional, Stassen, L P S, additional, Wiezer, M J, additional, Hazebroek, E J, additional, Smits, A B, additional, van Westreenen, H L, additional, Lange, J F, additional, Brandt, A, additional, Nijboer, W N, additional, Toorenvliet, B R, additional, Weidema, W F, additional, Coene, P P L O, additional, Mannaerts, G H H, additional, den Hartog, D, additional, de Vos, R J, additional, Zengerink, J F, additional, Hoofwijk, A G M, additional, Hulsewé, K W E, additional, Melenhorst, J, additional, Stoot, J H M B, additional, Steup, W H, additional, Huijstee, P J, additional, Merkus, J W S, additional, Wever, J J, additional, Maring, J K, additional, Heisterkamp, J, additional, van Grevenstein, W M U, additional, Vriens, M R, additional, Besselink, M G H, additional, Borel Rinkes, I H M, additional, Witkamp, A J, additional, Slooter, G D, additional, Konsten, J L M, additional, Engel, A F, additional, Pierik, E G J M, additional, Frakking, T G, additional, van Geldere, D, additional, Patijn, G A, additional, D'Hoore, A J L, additional, de Buck van Overstraeten, A, additional, Miserez, M, additional, Terrasson, I, additional, Wolthuis, A, additional, and De Blasiis, M G, additional

Published
2015
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100. Intensified follow-up in colorectal cancer patients using frequent Carcino-Embryonic Antigen (CEA) measurements and CEA-triggered imaging: Results of the randomized “CEAwatch” trial

Author

Verberne, C.J., primary, Zhan, Z., additional, van den Heuvel, E., additional, Grossmann, I., additional, Doornbos, P.M., additional, Havenga, K., additional, Manusama, E., additional, Klaase, J., additional, van der Mijle, H.C.J., additional, Lamme, B., additional, Bosscha, K., additional, Baas, P., additional, van Ooijen, B., additional, Nieuwenhuijzen, G., additional, Marinelli, A., additional, van der Zaag, E., additional, Wasowicz, D., additional, de Bock, G.H., additional, and Wiggers, T., additional

Published
2015
Full Text
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