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52. Nontraumatic Pediatric Intracerebral Hemorrhage

Author

Boulouis, Gregoire, Blauwblomme, Thomas, Hak, Jean François, Benichi, Sandro, Kirton, Adam, Meyer, Philippe, Chevignard, Mathilde, Tournier-Lasserve, Elisabeth, Mackay, Mark T., Chabrier, Stéphane, Cordonnier, Charlotte, Kossorotoff, Manoëlle, and Naggara, Olivier

Published
2019
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53. Towards a Consensus-Based Classification of Childhood Arterial Ischemic Stroke

Author

Bernard, Timothy J, Manco-Johnson, Marilyn J, Lo, Warren, MacKay, Mark T, Ganesan, Vijeya, deVeber, Gabrielle, Goldenberg, Neil A, Armstrong-Wells, Jennifer, Dowling, Michael M, Roach, E Steve, Tripputi, Mark, Fullerton, Heather J, Furie, Karen L, Benseler, Susanne M, Jordan, Lori C, Kirton, Adam, and Ichord, Rebecca

Subjects
Brain Disorders, Neurosciences, Pediatric, Stroke, Algorithms, Brain Ischemia, Cerebral Arterial Diseases, Child, Consensus, Delphi Technique, Humans, Observer Variation, Registries, Reproducibility of Results, pediatric, classification, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeThe implementation of uniform nomenclature and classification in adult arterial ischemic stroke (AIS) has been critical for defining outcomes and recurrence risks according to etiology and in developing risk-stratified treatments. In contrast, current classification and nomenclature in childhood AIS are often overlapping or contradictory. Our purpose was to develop a comprehensive consensus-based classification system for childhood AIS.MethodsUsing a modified-Delphi method, members of the International Pediatric Stroke Study (IPSS) developed the Childhood AIS Standardized Classification And Diagnostic Evaluation (CASCADE) criteria. Two groups of pediatric stroke specialists from the IPSS classified 7 test cases using 2 methods each: (1) classification typical of the individual clinician's current clinical practice; and (2) classification based on the CASCADE criteria. Group 1 underwent in-person training in the utilization of the CASCADE criteria. Group 2 classified the same cases via an online survey, including definitions but without training. Inter-rater reliability (IRR) was assessed via multi-rater unweighted κ-statistic.ResultsIn Group 1 (with training), IRR was improved using CASCADE criteria (κ=0.78, 95% CI=[0.49, 0.94]), compared with typical clinical practice (κ=0.40, 95% CI=[0.11, 0.60]). In Group 2 (without training), IRR was lower than among trained raters (κ=0.61, 95% CI=[0.29, 0.77]), but higher than current practice (κ=0.23, 95% CI=[0.03, 0.36]).ConclusionsA new, consensus-based classification system for childhood AIS, the CASCADE criteria, can be used to classify cases with good IRR. These preliminary findings suggest that the CASCADE criteria may be particularity useful in the setting of prospective multicenter studies in childhood-onset AIS, where standardized training of investigators is feasible.

Published
2012

58. Whole Genome Sequencing to Resolve the Genomic Architecture of Cerebral Palsy in a Canadian Cohort (P13-9.003)

Author

Oskoui, Maryam, primary, Zarrei, Mehdi, additional, Engchuan, Worrawat, additional, Sondheimer, Neal, additional, Thiruv, Bhooma, additional, Higginbotham, Edward, additional, Thapa, Ritesh, additional, Behlim, Tarannum, additional, Aimola, Sabrina, additional, Wei, John, additional, Danthi, Prakroothi, additional, Pellecchia, Giovanna, additional, Ho, Karen, additional, de Rijke, Jill, additional, Howe, Jennifer, additional, Nalpathamkalam, Thomas, additional, Manshaei, Roozbeh, additional, Whitney, Joseph, additional, Patel, Rohan, additional, Hamdan, Omar, additional, Shaath, Rulan, additional, Knights, Shannon, additional, Trost, Brett, additional, Samdup, Dawa, additional, MCCORMICK, ANNA, additional, Hunt, Carolyn, additional, Kirton, Adam, additional, Kawamura, Anne, additional, Mesterman, Ronit, additional, Gorter, Jan Willem, additional, Dlamini, Nomazulu, additional, Merico, Daniele, additional, Yuen, Ryan, additional, Shevell, Michael, additional, Stavropoulos, Dimitri, additional, Wintle, Richard, additional, Fehlings, Darcy, additional, and Scherer, Stephen, additional

Published
2023
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70. Risk of Intracranial Hemorrhage Following Intravenous tPA (Tissue-Type Plasminogen Activator) for Acute Stroke Is Low in Children

Author

Amlie-Lefond, Catherine, Shaw, Dennis W.W., Cooper, Andrew, Wainwright, Mark S., Kirton, Adam, Felling, Ryan J., Abraham, Michael G., Mackay, Mark T., Dowling, Michael M., Torres, Marcela, Rivkin, Michael J., Grabowski, Eric F., Lee, Sarah, Kurz, Jonathan E., McMillan, Hugh J., Barry, Dwight, Lee-Eng, Jacqueline, and Ichord, Rebecca N.

Published
2020
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71. Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016

Author

Bikson, Marom, Grossman, Pnina, Thomas, Chris, Zannou, Adantchede Louis, Jiang, Jimmy, Adnan, Tatheer, Mourdoukoutas, Antonios P., Kronberg, Greg, Truong, Dennis, Boggio, Paulo, Brunoni, André R., Charvet, Leigh, Fregni, Felipe, Fritsch, Brita, Gillick, Bernadette, Hamilton, Roy H., Hampstead, Benjamin M., Jankord, Ryan, Kirton, Adam, Knotkova, Helena, Liebetanz, David, Liu, Anli, Loo, Colleen, Nitsche, Michael A., Reis, Janine, Richardson, Jessica D., Rotenberg, Alexander, Turkeltaub, Peter E., and Woods, Adam J.

Published
2016
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75. Structural brain network lateralization across childhood and adolescence

Author

Craig, Brandon T., primary, Geeraert, Bryce, additional, Kinney‐Lang, Eli, additional, Hilderley, Alicia J., additional, Yeates, Keith O., additional, Kirton, Adam, additional, Noel, Melanie, additional, MacMaster, Frank P., additional, Bray, Signe, additional, Barlow, Karen M., additional, Brooks, Brian L., additional, Lebel, Catherine, additional, and Carlson, Helen L., additional

Published
2022
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83. Risk Factors for Term-Born Periventricular White Matter Injury in Children With Cerebral Palsy: A Case-Control Study

Author

Marefi, Amaar, Husein, Nafisa, Dunbar, Mary, Dewey, Deborah, Letourneau, Nicole, Oskoui, Maryam, Kirton, Adam, and Shevell, Michael I.

Subjects
Male, Pregnancy Complications, Pregnancy, Risk Factors, Cerebral Palsy, Case-Control Studies, Humans, Female, White Matter, Research Article, Alberta
Abstract

OBJECTIVE: The aim of this study was to identify possible risk factors associated with term-born children with cerebral palsy (CP) and periventricular white matter injury (PVWMI) on imaging. METHODS: This is a case-controlled study restricted to term-born children with CP with the cases extracted from the Canadian Cerebral Palsy Registry and controls from Alberta Pregnancy Outcomes and Nutrition (APrON) study. A diagnosis of PVWMI was performed based on expert categorization of MRI reports. Risk factor variables were selected a priori; these included pregnancy complications, antenatal toxin exposure, perinatal infection, sex, small for gestational age, and perinatal adversity (i.e., neonatal encephalopathy presumably on the basis of intrapartum hypoxia-ischemia). We used multivariable analyses to calculate odds ratios (ORs) and their 95% CIs. RESULTS: A total of 160 cases (7.06% of the registry sample) were compared with 1,950 controls. Of the term-born PVWMI participants, 59.4% were male and 13.5% were born to mothers of extreme maternal age. Multivariable analysis of each risk factor controlled for weight showed PVWMI is associated with pregnancy complications (OR = 3.35; 95% CI = 2.23–4.94), antenatal toxin exposure (OR = 2.45; 95% CI = 1.67–3.55), perinatal infection (OR = 3.61; 95% CI = 1.96–6.29), and perinatal adversity (OR = 2.03; 95% CI = 1.42–2.94). Term-born male participants were not more likely to experience PVWMI compared with female participants (OR = 1.37; 95% CI = 0.98–1.93). Multiple regression analyses suggested independent associations between PVWMI and pregnancy complications (OR = 3.75; 95% CI 2.46–5.62), antenatal toxin exposure (OR = 2.80; 95% CI 1.88–4.12), perinatal infection (OR = 4.62; 95% CI 2.46–8.42), and perinatal adversity (OR = 2.49; 95% CI = 1.71–3.69). DISCUSSION: Risk factors such as pregnancy complications, antenatal toxin exposure, perinatal infection, and perinatal adversity are associated with PVWMI in term-born children, suggesting perhaps variable interactions between antenatal and perinatal factors to yield this under-recognized CP phenotype.

Published
2022

86. International Prevalence and Mechanisms of SARS-CoV-2 in Childhood Arterial Ischemic Stroke During the COVID-19 Pandemic

Author

Beslow, Lauren A., primary, Agner, Shannon C., additional, Santoro, Jonathan D., additional, Ram, Dipak, additional, Wilson, Jenny L., additional, Harrar, Dana, additional, Appavu, Brian, additional, Fraser, Stuart M., additional, Rossor, Thomas, additional, Torres, Marcela D., additional, Kossorotoff, Manoëlle, additional, Zuñiga Zambrano, Yenny C., additional, Hernández-Chávez, Marta, additional, Hassanein, Sahar M.A., additional, Zafeiriou, Dimitrios, additional, Dowling, Michael M., additional, Kopyta, Ilona, additional, Stence, Nicholas V., additional, Bernard, Timothy J., additional, Dlamini, Nomazulu, additional, Abd El-Hamid Rihan, Ahmed, additional, Mohammed, Maha, additional, Farid, Moustafa, additional, Guergues, Wessam S.S., additional, Babiker, Mohamed O.E., additional, Hochberg, Oded, additional, Saracco, Paola, additional, Main, Thomas, additional, Mallick, Andrew, additional, Kala, Selina, additional, Philbrook, Bryan L., additional, Reddy, Kartik, additional, Ichord, Rebecca N., additional, Shih, Evelyn K., additional, Pearson, Rachel P., additional, Rafay, Mubeen F., additional, Sharma, Mukta, additional, Allen Staat, Mary, additional, Vadivelu, Sudhakar, additional, Duarte, Marvid, additional, Whitworth, Mary Suzanne, additional, Parakh, Manish, additional, Meesters, Kevin, additional, Roud, Charles-Joris, additional, Leruez- Ville, Marianne, additional, Ganesan, Vijeya, additional, Lehman, Laura L., additional, Rivkin, Michael, additional, Hernandez, Zulma, additional, Balut, Fernanda, additional, Celeste Buompadre, Maria, additional, Gómez Naranjo, Heidy J., additional, Gonzalez Alvarez, Veronica, additional, Bakeer, Nihal, additional, Garrison, Stephanie, additional, Belcher, Christopher, additional, Miller, Lorie, additional, Whitmore, Maria, additional, Amico, Giulia, additional, Severino, Mariasavina, additional, Bertamino, Marta, additional, Signa, Sara, additional, Sun, Lisa R., additional, Felling, Ryan J., additional, Kashyape, Pawan, additional, Gerstl, Lucia, additional, Kovacevic, Gordana, additional, Basu, Anna, additional, Taha, Yusri, additional, Lo, Warren D., additional, Yau, Maggie L.Y., additional, Peake, Deirdre, additional, Stevenson, Kim, additional, Gwer, Samson, additional, Andrade, Andrea, additional, Amlie- Lefond, Catherine, additional, Lee-Eng, Jacqueline, additional, Lee, Sarah, additional, Mailo, Janette, additional, Hausman- Kedem, Moran, additional, Jaiswal, Kamna, additional, Brown, Kellie, additional, Stojanovski, Belinda, additional, Mackay, Mark T, additional, Carolina Vargas Nino, Adriana, additional, McGregor, Daune, additional, deVeber, Gabrielle, additional, Bhathal, Ishvinder, additional, Liza Pulcine, NP, additional, Moharir, Mahendra, additional, Bjornson, Bruce, additional, Kim, Danny H.C., additional, Kirton, Adam, additional, Floer, Amalia, additional, Fox, Christine K., additional, Smith- Anderson, Christiana, additional, Wilt, Kelly, additional, Thompson, Vivian, additional, Chang, Michael L., additional, Tan, Marilyn, additional, Jordan, Lori C, additional, Grefe, Annette E., additional, Guilliams, Kristin, additional, and Noetzel, Michael J., additional

Published
2022
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88. Development and Validation of a Prediction Model for Perinatal Arterial Ischemic Stroke in Term Neonates

Author

Srivastava, Ratika, primary, Dunbar, Mary, additional, Shevell, Michael, additional, Oskoui, Maryam, additional, Basu, Anna, additional, Rivkin, Michael John, additional, Shany, Eilon, additional, de Vries, Linda S., additional, Dewey, Deborah, additional, Letourneau, Nicole, additional, Hill, Michael D., additional, and Kirton, Adam, additional

Published
2022
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92. Contributors

Author

Aaen, Gregory S., primary, Abend, Nicholas Scott, additional, Abou-Hamden, Amal, additional, Allen, Jeffrey C., additional, Amato, Anthony A., additional, Amlie-Lefond, Catherine, additional, Ashwal, Stephen, additional, Bailey, Russell C., additional, Bale, James F., additional, Banwell, Brenda, additional, Barañano, Kristin W., additional, Barkovich, A. James, additional, Barohn, Richard J., additional, Bartels, Ute K., additional, Bartnik-Olson, Brenda, additional, Barzilai, Ori, additional, Bassuk, Alexander, additional, Bearden, David R., additional, Ben-Sira, Liat, additional, Bernard, Timothy J., additional, Berry-Kravis, Elizabeth, additional, Beslow, Lauren A., additional, Biegel, Jaclyn A., additional, Billinghurst, Lori, additional, Birnbaum, Angela K., additional, Blackburn, Joanna S., additional, Bobowski, Nuala, additional, Boire, Adrienne, additional, Bönnemann, Carsten G., additional, Bonifacio, Sonia L., additional, Bonthius, Daniel J., additional, Borcherding, Breck, additional, Branchford, Brian R., additional, Brandsema, John, additional, Brennan, Kathryn M., additional, Brenton, J. Nicholas, additional, Brooks-Kayal, Amy R., additional, Brown, Lawrence W., additional, Buchalter, Jeffrey, additional, Camfield, Carol S., additional, Camfield, Peter R., additional, Campoy, Cristina, additional, Carpenter, Jessica L., additional, Chang, Taeun, additional, Chau, Vann, additional, Chi, Susan N., additional, Chiriboga, Claudia A., additional, Cho, Yoon-Jae, additional, Christian, Cindy W., additional, Chrestian, Nicholas, additional, Cilio, Maria Roberta, additional, Clark, Robin D., additional, Cohen, Bruce H., additional, Cohn, Ronald D., additional, Connolly, Anne M., additional, Constable, Todd, additional, Constantini, Shlomi, additional, Conway, Jeannine M., additional, Coulter, David L., additional, Cowan, Tina M., additional, Dale, Russell C., additional, Darbro, Benjamin, additional, Darras, Basil T., additional, Dastgir, Jahannaz, additional, De Meirleir, Linda, additional, De Vivo, Darryl C., additional, de Vries, Linda S., additional, Deisch, Jeremy K., additional, Deltenre, Paul, additional, Desai, Jay, additional, Descartes, Maria, additional, deVeber, Gabrielle, additional, Dhamne, Sameer C., additional, Diaz, Jullianne, additional, DiMauro, Salvatore, additional, Dobyns, William B., additional, Doherty, Dan, additional, Donner, Elizabeth J., additional, Dosenbach, Nico U.F., additional, Dowling, James J., additional, Drake, James M., additional, Ejerskov, Cecile, additional, Engel, Andrew G., additional, Enns, Gregory M., additional, Escolano-Margarit, María Victoria, additional, Etzion, Iris, additional, Fatemi, S. Ali, additional, Fehlings, Darcy L., additional, Feinberg, Michelle Lauren, additional, Ferriero, Donna M., additional, Filipek, Pauline A., additional, Finkel, Richard S., additional, Fisher, Paul G., additional, Flanigan, Kevin, additional, Foreman, Nicholas K., additional, Franco, Israel, additional, Frank, Yitzchak, additional, Fredrick, Douglas R., additional, Freeze, Hudson H., additional, Fuente-Mora, Cristina, additional, Furman, Joseph M., additional, Gallagher, Renata C., additional, Garel, Catherine, additional, Gertsch, Emily, additional, Gilbert, Donald L., additional, Gilles, Elizabeth E., additional, Giza, Christopher C., additional, Glaser, Carol A., additional, Glass, Hannah C., additional, Glauser, Tracy, additional, Glykys, Joseph, additional, Goldstein, Amy, additional, Gonorazky, Hernan Dario, additional, Gonzalez, Rodolfo, additional, Goodkin, Howard P., additional, Graham, John M., additional, Greninger, Alexander L., additional, Gronseth, Gary, additional, Gropman, Andrea L., additional, Grundy, Richard, additional, Guerrini, Renzo, additional, Gupta, Nalin, additional, Hahn, Jin S., additional, Hamblin, Milton H., additional, Hani, Abeer J., additional, Hanmantgad, Sharyu, additional, Harbert, Mary J., additional, Harini, Chellamani, additional, Harriott, Andrea M., additional, Heatwole, Chad, additional, Hershey, Andrew D., additional, Hirtz, Deborah G., additional, Holmes, Gregory L., additional, Holshouser, Barbara A., additional, Hurwitz, Kathleen A., additional, Hwang, Eugene, additional, Ichord, Rebecca N., additional, Jafar-Nejad, Paymaan, additional, Jain, Sejal V., additional, Jordan, Lori, additional, Kabbouche, Marielle A., additional, Kacperski, Joanne, additional, Kang, Peter B., additional, Kariannis, Matthias A., additional, Kaufmann, Horacio, additional, Kaye, Harper L., additional, Keating, Robert, additional, Kennedy, Colin R., additional, Khakoo, Yasmin, additional, Kirton, Adam, additional, Kissel, John T., additional, Knupp, Kelly G., additional, Korf, Bruce R., additional, Kossoff, Eric H., additional, Kothare, Sanjeev V., additional, Kupfer, Oren, additional, LaFrance, W. Curt, additional, Latal, Beatrice, additional, Leber, Steven M., additional, Lee, Jean-Pyo, additional, Leppik, Ilo E., additional, Lerman-Sagie, Tally, additional, Lerner, Jason T., additional, Leventer, Richard J., additional, Licht, Daniel J., additional, Lichter-Konecki, Uta, additional, Lidar, Zvi, additional, Liem, Djin Gie, additional, Loddenkemper, Tobias, additional, Long, Roger K., additional, Luc, Quyen N., additional, Mackay, Mark, additional, Majnemer, Annette, additional, Makhani, Naila, additional, Malinger, Gustavo, additional, Mandelbaum, David E., additional, Maricich, Stephen M., additional, Maski, Kiran P., additional, Mathur, Mudit, additional, Matthews, Dennis J., additional, McMahon, Kelly, additional, DeMara-Hoth, Megan B., additional, Mendelsohn, Bryce, additional, Mennella, Julie A., additional, Ment, Laura R., additional, Mercuri, Eugenio, additional, Michelson, David J., additional, Mikati, Mohamad A., additional, Mikhail, Fady M., additional, Miller, Steven Paul, additional, Milunsky, Jeff M., additional, Mink, Jonathan W., additional, Mirzaa, Ghayda M., additional, Mitchell, Wendy G., additional, Mohan, Michael A., additional, Mohassel, Payam, additional, Moharir, Mahendranath, additional, Monani, Umrao R., additional, Monje Deisseroth, Michelle, additional, Moodley, Manikum, additional, Mower, Andrew, additional, Moxley, Richard T., additional, Mueller, Sabine, additional, Muotri, Alysson R., additional, Nagamani, Sandesh C.S., additional, Narayanan, Mohan J., additional, Narayanan, Vinodh, additional, Nass, Ruth D., additional, Neul, Jeffrey L., additional, Nevo, Yoram, additional, Ng, Bobby G., additional, Nickels, Katherine C., additional, Nimmo, Graeme A.M., additional, Noetzel, Michael J., additional, Norcliffe-Kaufmann, Lucy, additional, Nordli, Douglas R., additional, Nowak-Göttl, Ulrike, additional, O'Brien, Hope L., additional, Oleszek, Joyce, additional, Oskoui, Maryam, additional, Paciorkowski, Alex R., additional, Packer, Roger J., additional, Packman, Seymour, additional, Palma, Jose-Alberto, additional, Pardo, Andrea C., additional, Parsons, Julie A., additional, Partridge, John Colin, additional, Pastores, Gregory M., additional, Patterson, Marc C., additional, Pearce, William J., additional, Pearl, Phillip L., additional, Penner, Melanie, additional, Percival, Leila, additional, Pereira, Marcia, additional, Pfister, Stefan M., additional, Phillips, John, additional, Plecko, Barbara, additional, Plioplys, Sigita, additional, Poduri, Annapurna, additional, Poisson, Sharon, additional, Pomeroy, Scott L., additional, Poretti, Andrea, additional, Powers, Scott W., additional, Pranzatelli, Michael R., additional, Przekop, Allison, additional, Rabie, Malcolm, additional, Rangasamy, Sampathkumar, additional, Raymond, Gerald V., additional, Reddy, Alyssa T., additional, Rendleman, Rebecca L., additional, Rho, Jong M., additional, Rodan, Lance H., additional, Roddy, Sarah M., additional, Rogers, Elizabeth E., additional, Rosenthal, Stephen M., additional, Rosman, N. Paul, additional, Ross, M. Elizabeth, additional, Rotenberg, Alexander, additional, Rust, Robert S., additional, Sanchez, Cheryl P., additional, Sanchez, Pedro, additional, Sánchez Fernández, Iván, additional, Sands, Tristan T., additional, Sanger, Terence D., additional, Sannagowdara, Kumar, additional, Scheinost, Dustin, additional, Scher, Mark S., additional, Schor, Nina F., additional, Schrauwen, Isabelle, additional, Segal, Michael M., additional, Seinfeld, Syndi, additional, Selcen, Duygu, additional, Seltzer, Laurie E., additional, Semrud-Clikeman, Margaret, additional, Shaw, Dennis W., additional, Shaywitz, Bennett A., additional, Shaywitz, Sally E., additional, Shellhaas, Renée A., additional, Sherr, Elliott H., additional, Sheth, Rita D., additional, Shevell, Michael I., additional, Shinnar, Shlomo, additional, Shofty, Ben, additional, Shu, Stanford K., additional, Shy, Michael E., additional, Silveira Moriyama, Laura, additional, Silvestri, Nicholas J., additional, Sims, Katherine B., additional, Singer, Harvey S., additional, Singhal, Nilika Shah, additional, Smith, Craig M., additional, Smith, Edward, additional, Smith, Stephen A., additional, Snyder, Evan Y., additional, Soul, Janet, additional, Spalink, Christy L., additional, Spencer, Karen A., additional, Stafstrom, Carl E., additional, Steinfeld, Robert, additional, Strober, Jonathan B., additional, Sullivan, Joseph, additional, Swaiman, Kenneth F., additional, Swoboda, Kathryn J., additional, Tate, Elizabeth D., additional, Tatum, William O., additional, Tein, Ingrid, additional, Tekulve, Kristyn, additional, Tenney, Jeffrey R., additional, Thiele, Elizabeth A., additional, Thompson-Stone, Robert, additional, Tochen, Laura, additional, Tormoehlen, Laura M., additional, Tran, Lily, additional, Trauner, Doris A., additional, Turnacioglu, Sinan O., additional, Ullrich, Nicole J., additional, Urion, David K., additional, Van Camp, Guy, additional, Van Hirtum-Das, Michèle, additional, van Karnebeek, Clara D.M., additional, Van Maldergem, Lionel, additional, Vanderver, Adeline, additional, Vitanza, Nicholas A., additional, von Rhein, Michael, additional, von Scheven, Emily, additional, Wagner, Ann, additional, Wainwright, Mark S., additional, Walker, Melissa A., additional, Walkup, John T., additional, Walsh, Laurence, additional, Walters-Sen, Lauren C., additional, Wang, Raymond Y., additional, Warner, Thomas T., additional, Whelan, Harry T., additional, Weinberg, Geoffrey A., additional, Wells, Elizabeth M., additional, Wheless, James W., additional, Wirrell, Elaine C., additional, Wisoff, Jeffrey H., additional, Wolf, Nicole I., additional, Wolfe, Gil I., additional, Wright, F. Virginia, additional, Wycliffe, Nathaniel D., additional, Yang, Michele L., additional, Yuskaitis, Christopher J., additional, Zoghbi, Huda Y., additional, and Zupanc, Mary L., additional

Published
2017
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96. Structural brain network lateralization across childhood and adolescence.

Author

Craig, Brandon T., Geeraert, Bryce, Kinney‐Lang, Eli, Hilderley, Alicia J., Yeates, Keith O., Kirton, Adam, Noel, Melanie, MacMaster, Frank P., Bray, Signe, Barlow, Karen M., Brooks, Brian L., Lebel, Catherine, and Carlson, Helen L.

Subjects
LARGE-scale brain networks, CEREBRAL dominance, ADOLESCENCE, YOUNG adults, WHITE matter (Nerve tissue)
Abstract

Developmental lateralization of brain function is imperative for behavioral specialization, yet few studies have investigated differences between hemispheres in structural connectivity patterns, especially over the course of development. The present study compares the lateralization of structural connectivity patterns, or topology, across children, adolescents, and young adults. We applied a graph theory approach to quantify key topological metrics in each hemisphere including efficiency of information transfer between regions (global efficiency), clustering of connections between regions (clustering coefficient [CC]), presence of hub‐nodes (betweenness centrality [BC]), and connectivity between nodes of high and low complexity (hierarchical complexity [HC]) and investigated changes in these metrics during development. Further, we investigated BC and CC in seven functionally defined networks. Our cross‐sectional study consisted of 211 participants between the ages of 6 and 21 years with 93% being right‐handed and 51% female. Global efficiency, HC, and CC demonstrated a leftward lateralization, compared to a rightward lateralization of BC. The sensorimotor, default mode, salience, and language networks showed a leftward asymmetry of CC. BC was only lateralized in the salience (right lateralized) and dorsal attention (left lateralized) networks. Only a small number of metrics were associated with age, suggesting that topological organization may stay relatively constant throughout school‐age development, despite known underlying changes in white matter properties. Unlike many other imaging biomarkers of brain development, our study suggests topological lateralization is consistent across age, highlighting potential nonlinear mechanisms underlying developmental specialization. [ABSTRACT FROM AUTHOR]

Published
2023
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98. Early intensive leg training to enhance walking in children with perinatal stroke: Protocol for a randomized controlled trial

Author

Hurd, Caitlin, Livingstone, Donna, Brunton, Kelly, Teves, Michelle, Zewdie, Ephrem, Smith, Allison, Ciechanski, Patrick, Gorassini, Monica A., Kirton, Adam, Watt, Man-Joe, Andersen, John, Yager, Jerome, and Yang, jaynie F.

Subjects
Stroke (Disease) -- Prevention, Therapeutics, Physiological -- Usage -- Physiological aspects -- Methods, Physical therapy -- Usage -- Physiological aspects -- Methods, Children -- Physiological aspects -- Usage -- Methods, Physical therapy for children -- Usage -- Physiological aspects -- Methods, Walking -- Methods -- Physiological aspects -- Usage, Health
Abstract

Background. Development of motor pathways is modulated by activity in these pathways, when they are maturing (ie, critical period). Perinatal stroke injures motor pathways, including the corticospinal tracts, reducing their [...]

Published
2017
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99. P288. Scalp-To-Cortex Distance in Youth With Major Depressive Disorder in Consideration of Precision Medicine Approaches to Noninvasive Brain Stimulation

Author

Chenji, Sneha, primary, Izquierdo, Jessica, additional, McLellan, Quinn, additional, Swansburg, Rose, additional, Stone, Kayla, additional, Jaworska, Natalia, additional, Kirton, Adam, additional, Croarkin, Paul E., additional, Wilkes, T. Christopher, additional, and MacMaster, Frank, additional

Published
2022
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