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Your search keyword '"King-Stephens, David"' showing total 95 results
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95 results on '"King-Stephens, David"'

51. Brain-responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas

Author

Jobst, Barbara C., primary, Kapur, Ritu, additional, Barkley, Gregory L., additional, Bazil, Carl W., additional, Berg, Michel J., additional, Bergey, Gregory K., additional, Boggs, Jane G., additional, Cash, Sydney S., additional, Cole, Andrew J., additional, Duchowny, Michael S., additional, Duckrow, Robert B., additional, Edwards, Jonathan C., additional, Eisenschenk, Stephan, additional, Fessler, A. James, additional, Fountain, Nathan B., additional, Geller, Eric B., additional, Goldman, Alica M., additional, Goodman, Robert R., additional, Gross, Robert E., additional, Gwinn, Ryder P., additional, Heck, Christianne, additional, Herekar, Aamr A., additional, Hirsch, Lawrence J., additional, King-Stephens, David, additional, Labar, Douglas R., additional, Marsh, W. R., additional, Meador, Kimford J., additional, Miller, Ian, additional, Mizrahi, Eli M., additional, Murro, Anthony M., additional, Nair, Dileep R., additional, Noe, Katherine H., additional, Olejniczak, Piotr W., additional, Park, Yong D., additional, Rutecki, Paul, additional, Salanova, Vicenta, additional, Sheth, Raj D., additional, Skidmore, Christopher, additional, Smith, Michael C., additional, Spencer, David C., additional, Srinivasan, Shraddha, additional, Tatum, William, additional, Van Ness, Paul, additional, Vossler, David G., additional, Wharen, Robert E., additional, Worrell, Gregory A., additional, Yoshor, Daniel, additional, Zimmerman, Richard S., additional, Skarpaas, Tara L., additional, and Morrell, Martha J., additional

Published
2017
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55. Long-termtreatmentwith responsive brain stimulation in adults with refractory partial seizures.

Author

Bergey, Gregory K., Morrell, Martha J., Mizrahi, Eli M., Goldman, Alica, King-Stephens, David, Nair, Dileep, Srinivasan, Shraddha, Jobst, Barbara, Gross, Robert E., Shields, Donald C., Barkley, Gregory, Salanova, Vicenta, Olejniczak, Piotr, Cole, Andrew, Cash, Sydney S., Noe, Katherine, Wharen, Robert, Worrell, Gregory, Murro, Anthony M., and Edwards, Jonathan

Published
2015
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59. Future Perspectives

Author

Herlopian, Aline, Herlopian, Aline, editor, Spencer, Dennis Dee, editor, Hirsch, Lawrence J., editor, and King-Stephens, David, editor

Published
2024
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89. Hypothalamic Hamartoma

Author

Herlopian, Aline, Herlopian, Aline, editor, Spencer, Dennis Dee, editor, Hirsch, Lawrence J., editor, and King-Stephens, David, editor

Published
2024
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94. The development of aperiodic neural activity in the human brain.

Author

Cross ZR, Gray SM, Dede AJO, Rivera YM, Yin Q, Vahidi P, Rau EMB, Cyr C, Holubecki AM, Asano E, Lin JJ, McManus OK, Sattar S, Saez I, Girgis F, King-Stephens D, Weber PB, Laxer KD, Schuele SU, Rosenow JM, Wu JY, Lam SK, Raskin JS, Chang EF, Shaikhouni A, Brunner P, Roland JL, Braga RM, Knight RT, Ofen N, and Johnson EL

Abstract

The neurophysiological mechanisms supporting brain maturation are fundamental to attention and memory capacity across the lifespan. Human brain regions develop at different rates, with many regions developing into the third and fourth decades of life. Here, in this preregistered study ( https://osf.io/gsru7 ), we analyzed intracranial EEG (iEEG) recordings from widespread brain regions in a large developmental cohort. Using task-based (i.e., attention to-be-remembered visual stimuli) and task-free (resting-state) data from 101 children and adults (5.93 - 54.00 years, 63 males; n electrodes = 5691), we mapped aperiodic (1/ƒ-like) activity, a proxy of excitation:inhibition (E:I) balance with steeper slopes indexing inhibition and flatter slopes indexing excitation. We reveal that aperiodic slopes flatten with age into young adulthood in both association and sensorimotor cortices, challenging models of early sensorimotor development based on brain structure. In prefrontal cortex (PFC), attentional state modulated age effects, revealing steeper task-based than task-free slopes in adults and the opposite in children, consistent with the development of cognitive control. Age-related differences in task-based slopes also explained age-related gains in memory performance, linking the development of PFC cognitive control to the development of memory. Last, with additional structural imaging measures, we reveal that age-related differences in gray matter volume are differentially associated with aperiodic slopes in association and sensorimotor cortices. Our findings establish developmental trajectories of aperiodic activity in localized brain regions and illuminate the development of PFC inhibitory control during adolescence in the development of attention and memory.

Published
2024
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95. Responsive neurostimulation as a treatment for super-refractory focal status epilepticus: a systematic review and case series.

Author

Ernst LD, Raslan AM, Wabulya A, Shin HW, Cash SS, Yang JC, Sagi V, King-Stephens D, Damisah EC, Ramos A, Hussain B, Toprani S, Brandman DM, Shahlaie K, Kanth K, Arain A, Peters A, Rolston JD, Berns M, Patel SI, and Uysal U

Subjects
Humans, Retrospective Studies, Neoplasm Recurrence, Local, Treatment Outcome, Status Epilepticus therapy, Status Epilepticus etiology, Drug Resistant Epilepsy therapy
Abstract

Objective: Super-refractory status epilepticus (SRSE) has high rates of morbidity and mortality. Few published studies have investigated neurostimulation treatment options in the setting of SRSE. This systematic literature review and series of 10 cases investigated the safety and efficacy of implanting and activating the responsive neurostimulation (RNS) system acutely during SRSE and discusses the rationale for lead placement and selection of stimulation parameters., Methods: Through a literature search (of databases and American Epilepsy Society abstracts that were last searched on March 1, 2023) and direct contact with the manufacturer of the RNS system, 10 total cases were identified that utilized RNS acutely during SE (9 SRSE cases and 1 case of refractory SE [RSE]). Nine centers obtained IRB approval for retrospective chart review and completed data collection forms. A tenth case had published data from a case report that were referenced in this study. Data from the collection forms and the published case report were compiled in Excel., Results: All 10 cases presented with focal SE: 9 with SRSE and 1 with RSE. Etiology varied from known lesion (focal cortical dysplasia in 7 cases and recurrent meningioma in 1) to unknown (2 cases, with 1 presenting with new-onset refractory focal SE [NORSE]). Seven of 10 cases exited SRSE after RNS placement and activation, with a time frame ranging from 1 to 27 days. Two patients died of complications due to ongoing SRSE. Another patient's SE never resolved but was subclinical. One of 10 cases had a device-related significant adverse event (trace hemorrhage), which did not require intervention. There was 1 reported recurrence of SE after discharge among the cases in which SRSE resolved up to the defined endpoint., Conclusions: This case series offers preliminary evidence that RNS is a safe and potentially effective treatment option for SRSE in patients with 1-2 well-defined seizure-onset zone(s) who meet the eligibility criteria for RNS. The unique features of RNS offer multiple benefits in the SRSE setting, including real-time electrocorticography to supplement scalp EEG for monitoring SRSE progress and response to treatment, as well as numerous stimulation options. Further research is indicated to investigate the optimal stimulation settings in this unique clinical scenario.

Published
2023
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