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52. The Engineering Council's influence on Building Services Engineering education and qualifications : towards an internationalist education and training model

Author

King, D. C., Tucker, M. P., and Cotgrave, A.

Subjects
710, L Education (General), LC Special aspects of education, TA Engineering (General). Civil engineering (General), TH Building construction
Abstract

A large number of Building Services Engineering (BSE) graduates from UK universities either already live and work abroad, or aspire to do so, and the destinations for such migrants are most often English-speaking countries or countries where English is commonly used in business. Academic programmes in BSE are usually professionally accredited by the Chartered Institution of Building Services Engineers (CIBSE) under licence from the Engineering Council (EC). In the common destination countries for UK BSE graduates the Washington, Sydney and Dublin Accord (WSDA) agreements prevail, meaning that there is a mutual recognition of engineering qualifications and professional accreditation of academic courses, and this facilitates international mobility. Since it is widely accepted that buildings account for as much as 50% of greenhouse gas emissions worldwide, it could be said that there is a worldwide sustainability agenda with respect to buildings. The common factor across national boundaries is that Building Services Engineers, as central members of building design teams, must provide much of the specialist practical knowledge to enable more energy efficient buildings to be designed and constructed, and it is therefore likely that UK educated engineers will be working in far more varied overseas locations in the near future. The main aim of the work is to synthesise an education and training model to encourage and enable international mobility of UK BSE graduates, and to carry out some evaluation of this model. This work sets out initially to question whether a UK education in BSE necessarily provides UK graduates with the best possible skillset for work abroad. The influence of the EC upon the content of BSE study programmes has been examined, and the research assesses the benefits of the EC’s influence in countries with different economic and political priorities to the UK, other western economies and to the WSDA countries. Following identification and analysis of the main issues, the model was constructed and evaluations were made using semi-structured interviews. The methodology used in this research is necessarily underpinned by a pragmatist paradigm, which has led to the use of a mixed methods blended approach. In addition to thorough review and analysis of literature, the practical methods employed include a questionnaire survey and semi-structured interviews in three phases: an exploratory phase, an in-depth analysis, and a concluding phase. The early conclusions indicated that the EC influence upon BSE study programmes is generally regarded as necessary and beneficial, since it provides an engineering skillset that is internationally respected and recognised. There is, however, less confidence in applying this in an international arena outside of the WSDA umbrella since different parts of the world face different economic challenges, divergent societal imperatives, and diverse attitudes to sustainability and green issues. An education and training model was constructed to address these issues and, after initial testing, was found generally to be a workable proposition to enhance the international prospects of UK BSEs, and further, could be adopted in the UK under the auspices of the Degree Apprenticeship initiatives. Such a model is, however, unlikely to be adopted in many overseas locations due to differing cultural views on the value of work-based learning and apprenticeship.

Published
2017
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53. High spatial resolution optical imaging of the multiple T Tauri system LkH{\alpha} 262/LkH{\alpha} 263

Author

Velasco, S., Rebolo, R., Oscoz, A., Mackay, C., Labadie, L., Garrido, A. Pérez, Crass, J., Díaz-Sánchez, A., Femenía, B., González-Escalera, V., King, D. L., López, R. L., Puga, M., Rodríguez-Ramos, L. F., and Zuther, J.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We report high spatial resolution i' band imaging of the multiple T Tauri system LkH$\alpha$ 262/LkH$\alpha$ 263 obtained during the first commissioning period of the Adaptive Optics Lucky Imager (AOLI) at the 4.2 m William Herschel Telescope, using its Lucky Imaging mode. AOLI images have provided photometry for each of the two components LkH$\alpha$ 263 A and B (0.41 arcsec separation) and marginal evidence for an unresolved binary or a disc in LkH$\alpha$ 262. The AOLI data combined with previously available and newly obtained optical and infrared imaging show that the three components of LkH$\alpha$ 263 are co-moving, that there is orbital motion in the AB pair, and, remarkably, that LkH$\alpha$ 262-263 is a common proper motion system with less than 1 mas/yr relative motion. We argue that this is a likely five-component gravitationally bounded system. According to BT-settl models the mass of each of the five components is close to 0.4 M$_{\odot}$ and the age is in the range 1-2 Myr. The presence of discs in some of the components offers an interesting opportunity to investigate the formation and evolution of discs in the early stages of multiple very low-mass systems. In particular, we provide tentative evidence that the disc in 263C could be coplanar with the orbit of 263AB., Comment: 11 pages, 7 figures, Accepted 2016 May 4

Published
2016
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57. Fast-ion orbit origin of neutron emission spectroscopy measurements in the JET DT campaign

Author

Järleblad, H., Stagner, L., Eriksson, Jacob, Nocente, M., Kirov, K., Rud, M., Schmidt, B. S., Maslov, M., King, D., Keeling, D., Maggi, C., Garcia, J., Lerche, E. A., Mantica, P., Dong, Y., Salewski, M., Järleblad, H., Stagner, L., Eriksson, Jacob, Nocente, M., Kirov, K., Rud, M., Schmidt, B. S., Maslov, M., King, D., Keeling, D., Maggi, C., Garcia, J., Lerche, E. A., Mantica, P., Dong, Y., and Salewski, M.

Abstract

In the JET DTE2 deuterium-tritium campaign, neutron diagnostics were employed to measure 14 MeV neutrons originating from D(T,n)4He reactions. In discharge 99965, a diamond matrix detector (KM14) and a magnetic proton recoil (MPRu) detector with a vertical and an oblique line-of-sight were used, respectively. At the timepoints of interest, a significant decrease in the expected diagnostic signals can be observed as electromagnetic wave heating in the ion cyclotron range of frequencies (ICRF) is switched off. Utilizing only TRANSP simulation data, the fast-ion distribution is found to have been likely composed mostly of trapped orbits. In contrast, analysis performed using orbit weight functions revealed that the majority of neutrons in the KM14 MeV and MPRu

Published
2024
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58. Impact of interaction between RF waves and fast NBI ions on the fusion performance in JET DTE2 campaign

Author

Kirov, K. K., Challis, C. D., De la Luna, E., Eriksson, Jacob, Gallart, D., Garcia, J., Gorelenkova, M., Hobirk, J., Jacquet, P., Kappatou, A., Kazakov, Y. O., Keeling, D., King, D., Lerche, E., Maggi, C., Mailloux, J., Mantica, P., Mantsinen, M., Maslov, M., Menmuir, S., Siren, P., Stancar, Z., Van Eester, D., Kirov, K. K., Challis, C. D., De la Luna, E., Eriksson, Jacob, Gallart, D., Garcia, J., Gorelenkova, M., Hobirk, J., Jacquet, P., Kappatou, A., Kazakov, Y. O., Keeling, D., King, D., Lerche, E., Maggi, C., Mailloux, J., Mantica, P., Mantsinen, M., Maslov, M., Menmuir, S., Siren, P., Stancar, Z., and Van Eester, D.

Abstract

This work presents a study of the interaction between radio frequency (RF) waves used for ion cyclotron resonance heating and the fast deuterium (D) and tritium (T) neutral Beam injected (NBI) ions in DT plasma. The focus is on the effects of this interaction, also referred to as synergistic effects, on the fusion performance in the recent JET DTE2 campaign. Experimental data from dedicated pulses at 3.43 T/2.3 MA heated at (i) 51.4 MHz, giving the central minority H and n = 2 D, and at (ii) 32.2 MHz for the central minority 3He and n = 2 T. Resonances are analysed and conclusions are drawn and supported by modelling of the synergistic effects. Modelling with transport code TRANSP runs with and without the RF kick operator predict a moderate increase, of about 10%, in DT rates for the case of the RF wave-fast D NBI ion interactions at the n = 2 harmonic of ion cyclotron resonance, and a negligible impact due to synergistic interaction between fast T NBI ions and RF waves. JETTO modelling gives a 29% enhancement in fusion rates due to the interction between RF waves and fast D NBI ions, and an 18% enhancement in fast T NBI ions. Analysis of experimental neutron rates compared to TRANSP predictions without synergistic effects and magnetic proton recoil neutron spectrometer indicate an enhancement of approximately 25%-28% in fusion rates due to RF interaction with fast D ions, and an enhancement of approximately 5%-8% when RF waves and fast T NBI ions are interacting. The contributions of various heating and fast ion sources are assessed and discussed.

Published
2024
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59. Fast-ion orbit origin of neutron emission spectroscopy measurements in the JET DT campaign

Author

Järleblad, H, Stagner, L, Eriksson, J, Nocente, M, Kirov, K, Rud, M, Schmidt, B, Maslov, M, King, D, Keeling, D, Maggi, C, Garcia, J, Lerche, E, Mantica, P, Dong, Y, Salewski, M, Schmidt, BS, Lerche, EA, Järleblad, H, Stagner, L, Eriksson, J, Nocente, M, Kirov, K, Rud, M, Schmidt, B, Maslov, M, King, D, Keeling, D, Maggi, C, Garcia, J, Lerche, E, Mantica, P, Dong, Y, Salewski, M, Schmidt, BS, and Lerche, EA

Abstract

In the JET DTE2 deuterium-tritium campaign, neutron diagnostics were employed to measure 14 MeV neutrons originating from D(T,n)4He reactions. In discharge 99965, a diamond matrix detector (KM14) and a magnetic proton recoil (MPRu) detector with a vertical and an oblique line-of-sight were used, respectively. At the timepoints of interest, a significant decrease in the expected diagnostic signals can be observed as electromagnetic wave heating in the ion cyclotron range of frequencies (ICRF) is switched off. Utilizing only TRANSP simulation data, the fast-ion distribution is found to have been likely composed mostly of trapped orbits. In contrast, analysis performed using orbit weight functions revealed that the majority of neutrons in the KM14 Ed=9.3 MeV and MPRu Xcm=33 cm measurement bins are to have originated from fast deuterium ions on co-passing orbits. This work explains the perhaps surprising results and shows that the relative signal decrease as ICRF heating is switched off is largest for counter-passing orbits. Finally, for the magnetic equilibria of interest, it is shown how stagnation orbits, corresponding to similar to 1 % of the fast-ion distribution, were completely unobservable by the KM14 diagnostic.

Published
2024

60. Analysis of fusion alphas interaction with RF waves in D-T plasma at JET

Author

Kirov, K. K., Auriemma, F., Bonofiglo, P. J., Challis, C. D., De la Luna, E., Eriksson, Jacob, Gallart, D., Garcia, J., Gorelenkova, M., Hobirk, J., Jacquet, P., Kappatou, A., Kazakov, Y., Keeling, D., King, D., Kiptily, V., Lerche, E., Maggi, C., Mailloux, J., Mantica, P., Mantsinen, M., Maslov, M., Menmuir, S., Sharma, R., Siren, P., Stancar, Z., Van Eester, D., Kirov, K. K., Auriemma, F., Bonofiglo, P. J., Challis, C. D., De la Luna, E., Eriksson, Jacob, Gallart, D., Garcia, J., Gorelenkova, M., Hobirk, J., Jacquet, P., Kappatou, A., Kazakov, Y., Keeling, D., King, D., Kiptily, V., Lerche, E., Maggi, C., Mailloux, J., Mantica, P., Mantsinen, M., Maslov, M., Menmuir, S., Sharma, R., Siren, P., Stancar, Z., and Van Eester, D.

Abstract

This work studies the influence of radio frequency (RF) waves in the ion cyclotron resonance heating (ICRH) range of frequencies on fusion alphas during the recent JET D-T campaign. Fusion alphas from D-T reactions are created with energies of about 3.5 MeV and therefore have significant Doppler shifts enabling synergistic interactions between them and RF waves at a broad range of frequencies, including the ones foreseen for future fusion machines in ITER (Schneider et al 2021 Nucl. Fusion 61 126058) and SPARC (Creely et al 2020 J. Plasma Phys. 86 865860502). Resonant interactions between RF waves and alphas, also called synergistic effects, will modify the alpha distribution and ultimately will have an impact on alpha orbit losses and heating. Data from JET 3.43 T/2.3 MA pulses based on the hybrid scenario (Hobirk et al 2023 Nucl. Fusion; Hobirk et al 29th IAEA FEC23 Conf. (16-21 October 2023); Challis et al 48th EPS Conf. on Plasma Physics (27 June-1 July 2022) during the DTE2 campaign (Maggi et al 2023 Nucl. Fusion)) were used for the analysis in this study. The impact of synergistic effects on alpha orbit losses and alpha heating are assessed. The conclusions are based on the analysis of experimental data for fast alpha losses, i.e. measurements from neutral particle analyser (NPA), fast ion losses scintillator detector, Faraday cups (FCs), and TRANSP (Hawryluk et al 1980 Physics of Plasmas Close to Thermonuclear Conditions vol 1 (CEC) pp 19-46) simulations. Experimental data and TRANSP analysis indicates that there are indeed changes in the alpha distribution function (DF) due to interaction with RF waves. Data from the NPA show increased 4He flux in the range from a few hundred keV up to 800 keV for pulses with RF power, while TRANSP clearly shows modifications in the fast alpha DF for these energies. Data from the scintillator detector and the FCs were compared for pulses with and without ICRH power and versus cases with enhanced alpha losses due to MHD activ

Published
2024
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61. Observation of alpha-particles in recent D-T experiments on JET

Author

Kiptily, V. G., Challis, C. D., Dumont, R., Fitzgerald, M., Garcia, J., Garzotti, L., Ghani, Z., Hobirk, J., Jacquet, P., Kappatou, A., Keeling, D., Kazakov, Ye., Mantica, P., Mantsinen, M. J., Sharapov, S. E., Solano, E. R., Van Eester, D., Bonofiglo, P. J., Craciunescu, T., Dal Molin, A., Eriksson, Jacob, Goloborodko, V., Iliasova, M. V., Khilkevitch, E. M., King, D., Lengar, I., Nocente, M., Menmuir, S., Podesta, M., Poradzinski, M., Rigamonti, D., Rivero-Rodriguez, J., Stancar, Z., Shevelev, A. E., Siren, P., Sun, H., Taylor, D. M., Tardocchi, M., Beaumont, P., Belli, F., Cecil, F. E., Coelho, R., Curuia, M., Garcia-Munoz, M., Joffrin, E., Lowry, C., Lennholm, M., Lerche, E., Maggi, C. F., Mailloux, J., Marocco, D., Maslov, M., Von Thun, C. Perez, Rimini, F., Zoita, V., Kiptily, V. G., Challis, C. D., Dumont, R., Fitzgerald, M., Garcia, J., Garzotti, L., Ghani, Z., Hobirk, J., Jacquet, P., Kappatou, A., Keeling, D., Kazakov, Ye., Mantica, P., Mantsinen, M. J., Sharapov, S. E., Solano, E. R., Van Eester, D., Bonofiglo, P. J., Craciunescu, T., Dal Molin, A., Eriksson, Jacob, Goloborodko, V., Iliasova, M. V., Khilkevitch, E. M., King, D., Lengar, I., Nocente, M., Menmuir, S., Podesta, M., Poradzinski, M., Rigamonti, D., Rivero-Rodriguez, J., Stancar, Z., Shevelev, A. E., Siren, P., Sun, H., Taylor, D. M., Tardocchi, M., Beaumont, P., Belli, F., Cecil, F. E., Coelho, R., Curuia, M., Garcia-Munoz, M., Joffrin, E., Lowry, C., Lennholm, M., Lerche, E., Maggi, C. F., Mailloux, J., Marocco, D., Maslov, M., Von Thun, C. Perez, Rimini, F., and Zoita, V.

Abstract

The fusion reaction between deuterium and tritium, D(T,n)4 He is the main source of energy in future thermonuclear reactors. Alpha-particles (4 He-ions) born with an average energy of 3.5 MeV transferring energy to the thermal plasma during their slowing down, should provide the self-sustained D-T plasma burn. The adequate confinement of alpha-particles is essential to provide efficient heating of the bulk plasma and steady burning of a reactor plasma. That is why the fusion-born alpha-particle studies have been a priority task in the second D-T experiments (DTE2) on the Joint European Torus (JET) to understand the main mechanisms of their slowing down, redistribution and losses and to develop optimal plasma scenarios. JET with Be-wall and W-divertor, enhanced auxiliary heating systems and improved energetic-particle diagnostic capabilities, producing significant population of alpha-particles, provided the possibility for comprehensive studying of the alpha-particle behaviour. Selected results of the confined and lost alpha-particle measurements, evidence of alpha-particle self-heating and assessments of the fusion performance are presented in this paper giving an opportunity for further modelling and extrapolation to the International Thermonuclear Experimental Reactor and burning plasma reactors.

Published
2024
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62. JET machine operations in T&D-T

Author

King, D. B., Rubel, Marek, Zerbini, M., et al., King, D. B., Rubel, Marek, Zerbini, M., and et al.

Abstract

JET, the world's largest operating tokamak with unique Be/W wall and tritium handling capability, completed a Deuterium-Tritium (D-T) campaign in 2021 (Maggi et al 29th Fusion Energy Conf.) following a decade of preparatory experiments, dedicated enhancements, technical rehearsals and training (Horton et al 2016 Fusion Eng. Des. 109-111 925). Operation with tritium raises significant technical, safety and scientific challenges not encountered in standard protium or deuterium operation. This contribution describes the tritium operational requirements, pulses and technical preparations, new operating procedures, lessons learned and details on the achieved operational availability and performance. The preparation and execution of the recent JET tritium experiments benefitted from the previous experience in 1991 (Preliminary Tritium Experiment), 1997 (DTE1 campaign) and 2003 (Trace Tritium Campaigns) and consisted of the following five phases: technical rehearsals and scenario preparation, tritium commissioning, 100% tritium campaign, D-T campaign (DTE2), tritium clean-up. Following the clean-up JET resumed normal operation and is currently undertaking a further D-T campaign (DTE3)., QC 20240926

Published
2024
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63. Gilteritinib as Post-Transplant Maintenance for Acute Myeloid Leukemia With Internal Tandem Duplication Mutation of FLT3

Author

Levis, M, Hamadani, M, Logan, B, Jones, R, Singh, A, Litzow, M, Wingard, J, Papadopoulos, E, Perl, A, Soiffer, R, Ustun, C, Ueda Oshima, M, Uy, G, Waller, E, Vasu, S, Solh, M, Mishra, A, Muffly, L, Kim, H, Mikesch, J, Najima, Y, Onozawa, M, Thomson, K, Nagler, A, Wei, A, Marcucci, G, Geller, N, Hasabou, N, Delgado, D, Rosales, M, Hill, J, Gill, S, Nuthethi, R, King, D, Wittsack, H, Mendizabal, A, Devine, S, Horowitz, M, Chen, Y, Agura, E, Altman, J, Anagnostopoulos, A, Anand, S, Artz, A, Aulitzky, W, Balderman, S, Ballen, K, Becker, M, Beguin, Y, Berkahn, L, Berneman, Z, Bhatt, V, Bilmon, I, Bonifazi, F, Briggs, A, Bruno, B, Brunstein, C, Byrne, M, Byrne, J, Cabrero, M, Cairoli, R, Carrum, G, Cerny, J, Cheong, J, Ciceri, F, Colorado, M, Cook, R, Couriel, D, Craddock, C, Damon, L, Deol, A, Desbrosses, Y, Di Grazia, C, Di Stasi, A, Dias, A, Dorritie, K, Essell, J, Eto, T, Farag, S, Forcade, E, Frankfurt, O, Fujiwara, S, Fukuda, T, Fukushima, K, Furst, S, Goto, T, Hall, A, Hatta, S, Hicheri, Y, Horwitz, M, Hou, H, How, J, Howard, D, Hsu, W, Huynh, A, Irvine, D, Ishikawa, T, Jamieson, K, Jedrzejczak, W, Jethava, Y, Jimenez, A, Jung, C, Kanda, J, Karakasis, D, Kato, J, Kekre, N, Khera, N, Klein, A, Kobbe, G, Kornblit, B, Kota, V, Lachance, S, Leber, B, Lee, C, Lee, J, Lin, T, Liu, T, Martelli, M, Martinez, C, Matsuoka, K, Mccarty, J, Mendez, L, Michelis, F, Mineishi, S, Mohty, M, Moors, I, Motyckova, G, Mueller, L, Nakamae, H, Nakano, N, Nathan, S, Nicholson, E, Norkin, M, Ogawa, Y, Olesen, G, Oluwole, O, Pantin, J, Paulson, K, Pemberton, L, Perera, T, Piatkowska-Jakubas, B, Poire, X, Protheroe, R, Rambaldi, A, Ritchie, D, Ross, K, Rubio, M, Santarone, S, Sanz Caballer, J, Sawa, M, Schaar, D, Scheid, C, Schriber, J, Seropian, S, Shah, N, Shore, T, Gil, J, Sobecks, R, Socie, G, Sprague, K, Spyridonidis, A, Stelljes, M, Stiff, P, Stuart, R, Tanaka, M, Tandra, A, Tholouli, E, Thomas, X, Tiribelli, M, Tomlinson, B, Tsirigotis, P, Tzachanis, D, Uchida, N, Ueda, M, Valcarcel Ferreiras, D, Wagner, E, Watson, A, Weisdorf, D, Wolschke, C, Wrobel, T, Yakoub-Agha, I, Yamauchi, T, Yared, J, Yeh, S, Yoon, S, Yoshihara, S, Null, N, Levis, Mark J., Hamadani, Mehdi, Logan, Brent, Jones, Richard J., Singh, Anurag K., Litzow, Mark, Wingard, John R., Papadopoulos, Esperanza B., Perl, Alexander E., Soiffer, Robert J., Ustun, Celalettin, Ueda Oshima, Masumi, Uy, Geoffrey L., Waller, Edmund K., Vasu, Sumithra, Solh, Melhem, Mishra, Asmita, Muffly, Lori, Kim, Hee-Je, Mikesch, Jan-Henrik, Najima, Yuho, Onozawa, Masahiro, Thomson, Kirsty, Nagler, Arnon, Wei, Andrew H., Marcucci, Guido, Geller, Nancy L., Hasabou, Nahla, Delgado, David, Rosales, Matt, Hill, Jason, Gill, Stanley C., Nuthethi, Rishita, King, Denise, Wittsack, Heather, Mendizabal, Adam, Devine, Steven M., Horowitz, Mary M., Chen, Yi-Bin, Agura, Ed, Altman, Jessica, Anagnostopoulos, Achiles, Anand, Sarah, Artz, Andrew, Aulitzky, Walter, Balderman, Sophia, Ballen, Karen, Becker, Michael, Beguin, Yves, Berkahn, Leanne, Berneman, Zwi, Bhatt, Vijaya, Bilmon, Ian, Bonifazi, Francesca, Briggs, Adrienne, Bruno, Benedetto, Brunstein, Claudio, Byrne, Michael, Byrne, Jenny, Cabrero, Monica, Cairoli, Roberto, Carrum, George, Cerny, Jan, Cheong, June-Won, Ciceri, Fabio, Colorado, Mercedes, Cook, Rachel, Couriel, Daniel, Craddock, Charles, Damon, Lloyd, Deol, Abhinav, Desbrosses, Yohan, Devine, Steve, Di Grazia, Carmela, Di Stasi, Antonio, Dias, Ajoy, Dorritie, Kathy, Essell, James, Eto, Tetsuya, Farag, Sherif, Forcade, Edouard, Frankfurt, Olga, Fujiwara, Shinichiro, Fukuda, Takahiro, Fukushima, Kentaro, Furst, Sabine, Goto, Tatsunori, Hall, Aric, Hatta, Shunsuke, Hicheri, Yosr, Horwitz, Mitchell, Hou, Hsin-An, How, Jonathan, Howard, Dianna, Hsu, Wei-Hsun (Blake), Huynh, Anne, Irvine, David, Ishikawa, Takayuki, Jamieson, Katarzyna, Jedrzejczak, Wieslaw, Jethava, Yogesh, Jimenez, Antonio, Jung, Chul Won, Kanda, Junya, Karakasis, Dimitrios, Kato, Jun, Kekre, Natasha, Khera, Nandita, Klein, Andreas, Kobbe, Guido, Kornblit, Brian, Kota, Vamsi, Lachance, Silvy, Leber, Brian, Lee, Catherine, Lee, Je Hwan, Lin, Tung-Liang, Liu, Ta-Chih, Martelli, Maurizio, Martinez, Carmen, Matsuoka, Kenichi, McCarty, John, Mendez, Lourdes, Michelis, Fotios, Mineishi, Shin, Mohty, Mohamad, Moors, Ine, Motyckova, Gabriela, Mueller, Lutz, Nakamae, Hirohisa, Nakano, Nobuaki, Nathan, Sunita, Nicholson, Emma, Norkin, Maxim, Ogawa, Yoshiaki, Olesen, Gitte, Oluwole, Olalekan, Pantin, Jeremy, Paulson, Kristjan, Pemberton, Lucy, Perera, Travis, Piatkowska-Jakubas, Beata, Poire, Xavier, Protheroe, Rachel, Rambaldi, Alessandro, Ritchie, David, Ross, Kelly, Rubio, Marie-Therese, Santarone, Stella, Sanz Caballer, Jaime, Sawa, Masashi, Schaar, Dale, Scheid, Christoph, Schriber, Jeffrey, Seropian, Stuart, Shah, Nilay, Shah, Nirav, Shore, Tsiporah, Gil, Jorge Sierra, Singh, Anurag, Sobecks, Ronald, Socie, Gerard, Soiffer, Robert, Sprague, Kellie, Spyridonidis, Alexandros, Stelljes, Matthias, Stiff, Patrick, Stuart, Robert, Tanaka, Masatsugu, Tandra, Anand, Tholouli, Eleni, Thomas, Xavier, Tiribelli, Mario, Tomlinson, Benjamin, Tsirigotis, Panagiotis, Tzachanis, Dimitrios, Uchida, Naoyuki, Ueda, Masumi, Valcarcel Ferreiras, David, Wagner, Eva, Watson, Anne-Marie, Weisdorf, Daniel, Wolschke, Christine, Wrobel, Tomasz, Yakoub-Agha, Ibrahim, Yamauchi, Takuji, Yared, Jean, Yeh, Su-Peng, Yoon, Sung-Soo, Yoshihara, Satoshi, null, null, Levis, M, Hamadani, M, Logan, B, Jones, R, Singh, A, Litzow, M, Wingard, J, Papadopoulos, E, Perl, A, Soiffer, R, Ustun, C, Ueda Oshima, M, Uy, G, Waller, E, Vasu, S, Solh, M, Mishra, A, Muffly, L, Kim, H, Mikesch, J, Najima, Y, Onozawa, M, Thomson, K, Nagler, A, Wei, A, Marcucci, G, Geller, N, Hasabou, N, Delgado, D, Rosales, M, Hill, J, Gill, S, Nuthethi, R, King, D, Wittsack, H, Mendizabal, A, Devine, S, Horowitz, M, Chen, Y, Agura, E, Altman, J, Anagnostopoulos, A, Anand, S, Artz, A, Aulitzky, W, Balderman, S, Ballen, K, Becker, M, Beguin, Y, Berkahn, L, Berneman, Z, Bhatt, V, Bilmon, I, Bonifazi, F, Briggs, A, Bruno, B, Brunstein, C, Byrne, M, Byrne, J, Cabrero, M, Cairoli, R, Carrum, G, Cerny, J, Cheong, J, Ciceri, F, Colorado, M, Cook, R, Couriel, D, Craddock, C, Damon, L, Deol, A, Desbrosses, Y, Di Grazia, C, Di Stasi, A, Dias, A, Dorritie, K, Essell, J, Eto, T, Farag, S, Forcade, E, Frankfurt, O, Fujiwara, S, Fukuda, T, Fukushima, K, Furst, S, Goto, T, Hall, A, Hatta, S, Hicheri, Y, Horwitz, M, Hou, H, How, J, Howard, D, Hsu, W, Huynh, A, Irvine, D, Ishikawa, T, Jamieson, K, Jedrzejczak, W, Jethava, Y, Jimenez, A, Jung, C, Kanda, J, Karakasis, D, Kato, J, Kekre, N, Khera, N, Klein, A, Kobbe, G, Kornblit, B, Kota, V, Lachance, S, Leber, B, Lee, C, Lee, J, Lin, T, Liu, T, Martelli, M, Martinez, C, Matsuoka, K, Mccarty, J, Mendez, L, Michelis, F, Mineishi, S, Mohty, M, Moors, I, Motyckova, G, Mueller, L, Nakamae, H, Nakano, N, Nathan, S, Nicholson, E, Norkin, M, Ogawa, Y, Olesen, G, Oluwole, O, Pantin, J, Paulson, K, Pemberton, L, Perera, T, Piatkowska-Jakubas, B, Poire, X, Protheroe, R, Rambaldi, A, Ritchie, D, Ross, K, Rubio, M, Santarone, S, Sanz Caballer, J, Sawa, M, Schaar, D, Scheid, C, Schriber, J, Seropian, S, Shah, N, Shore, T, Gil, J, Sobecks, R, Socie, G, Sprague, K, Spyridonidis, A, Stelljes, M, Stiff, P, Stuart, R, Tanaka, M, Tandra, A, Tholouli, E, Thomas, X, Tiribelli, M, Tomlinson, B, Tsirigotis, P, Tzachanis, D, Uchida, N, Ueda, M, Valcarcel Ferreiras, D, Wagner, E, Watson, A, Weisdorf, D, Wolschke, C, Wrobel, T, Yakoub-Agha, I, Yamauchi, T, Yared, J, Yeh, S, Yoon, S, Yoshihara, S, Null, N, Levis, Mark J., Hamadani, Mehdi, Logan, Brent, Jones, Richard J., Singh, Anurag K., Litzow, Mark, Wingard, John R., Papadopoulos, Esperanza B., Perl, Alexander E., Soiffer, Robert J., Ustun, Celalettin, Ueda Oshima, Masumi, Uy, Geoffrey L., Waller, Edmund K., Vasu, Sumithra, Solh, Melhem, Mishra, Asmita, Muffly, Lori, Kim, Hee-Je, Mikesch, Jan-Henrik, Najima, Yuho, Onozawa, Masahiro, Thomson, Kirsty, Nagler, Arnon, Wei, Andrew H., Marcucci, Guido, Geller, Nancy L., Hasabou, Nahla, Delgado, David, Rosales, Matt, Hill, Jason, Gill, Stanley C., Nuthethi, Rishita, King, Denise, Wittsack, Heather, Mendizabal, Adam, Devine, Steven M., Horowitz, Mary M., Chen, Yi-Bin, Agura, Ed, Altman, Jessica, Anagnostopoulos, Achiles, Anand, Sarah, Artz, Andrew, Aulitzky, Walter, Balderman, Sophia, Ballen, Karen, Becker, Michael, Beguin, Yves, Berkahn, Leanne, Berneman, Zwi, Bhatt, Vijaya, Bilmon, Ian, Bonifazi, Francesca, Briggs, Adrienne, Bruno, Benedetto, Brunstein, Claudio, Byrne, Michael, Byrne, Jenny, Cabrero, Monica, Cairoli, Roberto, Carrum, George, Cerny, Jan, Cheong, June-Won, Ciceri, Fabio, Colorado, Mercedes, Cook, Rachel, Couriel, Daniel, Craddock, Charles, Damon, Lloyd, Deol, Abhinav, Desbrosses, Yohan, Devine, Steve, Di Grazia, Carmela, Di Stasi, Antonio, Dias, Ajoy, Dorritie, Kathy, Essell, James, Eto, Tetsuya, Farag, Sherif, Forcade, Edouard, Frankfurt, Olga, Fujiwara, Shinichiro, Fukuda, Takahiro, Fukushima, Kentaro, Furst, Sabine, Goto, Tatsunori, Hall, Aric, Hatta, Shunsuke, Hicheri, Yosr, Horwitz, Mitchell, Hou, Hsin-An, How, Jonathan, Howard, Dianna, Hsu, Wei-Hsun (Blake), Huynh, Anne, Irvine, David, Ishikawa, Takayuki, Jamieson, Katarzyna, Jedrzejczak, Wieslaw, Jethava, Yogesh, Jimenez, Antonio, Jung, Chul Won, Kanda, Junya, Karakasis, Dimitrios, Kato, Jun, Kekre, Natasha, Khera, Nandita, Klein, Andreas, Kobbe, Guido, Kornblit, Brian, Kota, Vamsi, Lachance, Silvy, Leber, Brian, Lee, Catherine, Lee, Je Hwan, Lin, Tung-Liang, Liu, Ta-Chih, Martelli, Maurizio, Martinez, Carmen, Matsuoka, Kenichi, McCarty, John, Mendez, Lourdes, Michelis, Fotios, Mineishi, Shin, Mohty, Mohamad, Moors, Ine, Motyckova, Gabriela, Mueller, Lutz, Nakamae, Hirohisa, Nakano, Nobuaki, Nathan, Sunita, Nicholson, Emma, Norkin, Maxim, Ogawa, Yoshiaki, Olesen, Gitte, Oluwole, Olalekan, Pantin, Jeremy, Paulson, Kristjan, Pemberton, Lucy, Perera, Travis, Piatkowska-Jakubas, Beata, Poire, Xavier, Protheroe, Rachel, Rambaldi, Alessandro, Ritchie, David, Ross, Kelly, Rubio, Marie-Therese, Santarone, Stella, Sanz Caballer, Jaime, Sawa, Masashi, Schaar, Dale, Scheid, Christoph, Schriber, Jeffrey, Seropian, Stuart, Shah, Nilay, Shah, Nirav, Shore, Tsiporah, Gil, Jorge Sierra, Singh, Anurag, Sobecks, Ronald, Socie, Gerard, Soiffer, Robert, Sprague, Kellie, Spyridonidis, Alexandros, Stelljes, Matthias, Stiff, Patrick, Stuart, Robert, Tanaka, Masatsugu, Tandra, Anand, Tholouli, Eleni, Thomas, Xavier, Tiribelli, Mario, Tomlinson, Benjamin, Tsirigotis, Panagiotis, Tzachanis, Dimitrios, Uchida, Naoyuki, Ueda, Masumi, Valcarcel Ferreiras, David, Wagner, Eva, Watson, Anne-Marie, Weisdorf, Daniel, Wolschke, Christine, Wrobel, Tomasz, Yakoub-Agha, Ibrahim, Yamauchi, Takuji, Yared, Jean, Yeh, Su-Peng, Yoon, Sung-Soo, Yoshihara, Satoshi, and null, null

Abstract

PURPOSEAllogeneic hematopoietic cell transplantation (HCT) improves outcomes for patients with AML harboring an internal tandem duplication mutation of FLT3 (FLT3-ITD) AML. These patients are routinely treated with a FLT3 inhibitor after HCT, but there is limited evidence to support this. Accordingly, we conducted a randomized trial of post-HCT maintenance with the FLT3 inhibitor gilteritinib (ClinicalTrials.gov identifier: NCT02997202) to determine if all such patients benefit or if detection of measurable residual disease (MRD) could identify those who might benefit.METHODSAdults with FLT3-ITD AML in first remission underwent HCT and were randomly assigned to placebo or 120 mg once daily gilteritinib for 24 months after HCT. The primary end point was relapse-free survival (RFS). Secondary end points included overall survival (OS) and the effect of MRD pre- and post-HCT on RFS and OS.RESULTSThree hundred fifty-six participants were randomly assigned post-HCT to receive gilteritinib or placebo. Although RFS was higher in the gilteritinib arm, the difference was not statistically significant (hazard ratio [HR], 0.679 [95% CI, 0.459 to 1.005]; two-sided P =.0518). However, 50.5% of participants had MRD detectable pre- or post-HCT, and, in a prespecified subgroup analysis, gilteritinib was beneficial in this population (HR, 0.515 [95% CI, 0.316 to 0.838]; P =.0065). Those without detectable MRD showed no benefit (HR, 1.213 [95% CI, 0.616 to 2.387]; P =.575).CONCLUSIONAlthough the overall improvement in RFS was not statistically significant, RFS was higher for participants with detectable FLT3-ITD MRD pre- or post-HCT who received gilteritinib treatment. To our knowledge, these data are among the first to support the effectiveness of MRD-based post-HCT therapy.

Published
2024

64. Adaptive Optics and Lucky Imager (AOLI): presentation and first light

Author

Velasco, S., Rebolo, R., Mackay, C., Oscoz, A., King, D. L., Crass, J., Díaz-Sánchez, A., Femenía, B., González-Escalera, V., Labadie, L., López, R. L., Garrido, A. Pérez, Puga, M., Rodríguez-Ramos, L. F., and Zuther, J.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

In this paper we present the Adaptive Optics Lucky Imager (AOLI), a state-of-the-art instrument which makes use of two well proved techniques for extremely high spatial resolution with ground-based telescopes: Lucky Imaging (LI) and Adaptive Optics (AO). AOLI comprises an AO system, including a low order non-linear curvature wavefront sensor together with a 241 actuators deformable mirror, a science array of four 1024x1024 EMCCDs, allowing a 120x120 down to 36x36 arcseconds field of view, a calibration subsystem and a powerful LI software. Thanks to the revolutionary WFS, AOLI shall have the capability of using faint reference stars ({\it I\/} $\sim$ 16.5-17.5), enabling it to be used over a much wider part of the sky than with common Shack-Hartmann AO systems. This instrument saw first light in September 2013 at William Herschel Telescope. Although the instrument was not complete, these commissioning demonstrated its feasibility, obtaining a FWHM for the best PSF of 0.151$\pm$0.005 arcsec and a plate scale of 55.0$\pm$0.3 mas/pixel. Those observations served us to prove some characteristics of the interesting multiple T Tauri system LkH$\alpha$ 262-263, finding it to be gravitationally bounded. This interesting multiple system mixes the presence of proto-planetary discs, one proved to be double, and the first-time optically resolved pair LkH$\alpha$ 263AB (0.42 arcsec separation)., Comment: 6 pages, 4 figures

Published
2015

65. Improved Confinement in JET High {beta} Plasmas with an ITER-Like Wall

Author

Challis, C. D., Garcia, J., Beurskens, M., Buratti, P., Delabie, E., Drewelow, P., Frassinetti, L., Giroud, C., Hawkes, N., Hobirk, J., Joffrin, E., Keeling, D., King, D. B., Maggi, C. F., Mailloux, J., Marchetto, C., McDonald, D., Nunes, I., Pucella, G., Saarelma, S., and Simpson, J.

Subjects
Physics - Plasma Physics
Abstract

The replacement of the JET carbon wall (C-wall) by a Be/W ITER-like wall (ILW) has affected the plasma energy confinement. To investigate this, experiments have been performed with both the C-wall and ILW to vary the heating power over a wide range for plasmas with different shapes., Comment: 50 pages, 32 figures. This is an author-created, un-copyedited version of an article submitted for publication in Nuclear Fusion. IoP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it

Published
2015
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68. Acute Adenoviral Infection Elicits an Arrhythmogenic Substrate Prior to Myocarditis

Author

Padget, Rachel L., primary, Zeitz, Michael J., additional, Blair, Grace A., additional, Wu, Xiaobo, additional, North, Michael D., additional, Tanenbaum, Mira T., additional, Stanley, Kari E., additional, Phillips, Chelsea M., additional, King, D. Ryan, additional, Lamouille, Samy, additional, Gourdie, Robert G., additional, Hoeker, Gregory S., additional, Swanger, Sharon A., additional, Poelzing, Steven, additional, and Smyth, James W., additional

Published
2024
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71. Reconnaissance of the HR 8799 Exosolar System II: Astrometry and Orbital Motion

Author

Pueyo, L., Soummer, R., Hoffmann, J., Oppenheimer, R., Graham, J. R., Zimmerman, N., Zhai, C., Wallace, J. K., Vescelus, F., Veicht, A., Vasisht, G., Truong, T., Sivaramakrishnan, A., Shao, M., Roberts Jr., L. C., Roberts, J. E., Rice, E., Parry, I. R., Nilsson, R., Luszcz-Cook, S., Lockhart, T., Ligon, E. R., King, D., Hinkley, S., Hillenbrand, L., Hale, D., Dekany, R., Crepp, J. R., Cady, E., Burruss, R., Brenner, D., Beichman, C., and Baranec, C.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

We present an analysis of the orbital motion of the four sub-stellar objects orbiting HR8799. Our study relies on the published astrometric history of this system augmented with an epoch obtained with the Project 1640 coronagraph + Integral Field Spectrograph (IFS) installed at the Palomar Hale telescope. We first focus on the intricacies associated with astrometric estimation using the combination of an Extreme Adaptive Optics system (PALM-3000), a coronagraph and an IFS. We introduce two new algorithms. The first one retrieves the stellar focal plane position when the star is occulted by a coronagraphic stop. The second one yields precise astrometric and spectro-photometric estimates of faint point sources even when they are initially buried in the speckle noise. The second part of our paper is devoted to studying orbital motion in this system. In order to complement the orbital architectures discussed in the literature, we determine an ensemble of likely Keplerian orbits for HR8799bcde, using a Bayesian analysis with maximally vague priors regarding the overall configuration of the system. While the astrometric history is currently too scarce to formally rule out coplanarity, HR8799d appears to be misaligned with respect to the most likely planes of HR8799bce orbits. This misalignment is sufficient to question the strictly coplanar assumption made by various authors when identifying a Laplace resonance as a potential architecture. Finally, we establish a high likelihood that HR8799de have dynamical masses below 13 M_Jup using a loose dynamical survival argument based on geometric close encounters. We illustrate how future dynamical analyses will further constrain dynamical masses in the entire system., Comment: 26 pages, 18 figures

Published
2014
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72. Progress with applications of three-ion ICRF scenarios for fusion research: A review

Author

Wukitch, SJ, Bertelli, N, Bonoli, P, Kazakov, Y, Ongena, J, Nocente, M, Bobkov, V, Garcia, J, Kiptily, V, Schneider, M, Wukitch, S, Wright, J, Dreval, M, Kirov, K, Mazzi, S, Ochoukov, R, Sharapov, S, Štancar, Weisen, H, Baranov, Y, Baruzzo, M, Bierwage, A, Bilato, R, Chomiczewska, A, Coelho, R, Craciunescu, T, Crombé, K, Delabie, E, Luna, E, Dumont, R, Dumortier, P, Durodié, F, Eriksson, J, Fitzgerald, M, Galdon-Quiroga, J, Gallart, D, Garcia-Munoz, M, Giacomelli, L, Giroud, C, Gonzalez-Martin, J, Hakola, A, Henriques, R, Jacquet, P, Jepu, I, Johnson, T, Kappatou, A, Keeling, D, King, D, Klepper, C, Lauber, P, Lennholm, M, Lerche, E, Lomanowski, B, Lowry, C, Mantsinen, M, Maslov, M, Menmuir, S, Monakhov, I, Nabais, F, Nave, M, Noble, C, Panontin, E, Pinches, S, Polevoi, A, Rigamonti, D, Sahlberg, A, Salewski, M, Schneider, P, Sheikh, H, Shinohara, K, Siren, P, Sumida, S, Thorman, A, Tinguely, R, Valcarcel, D, Van Eester, D, Schoor, M, Varje, J, Weiland, M, Wendler, N, Kazakov Y. O., Ongena J., Nocente M., Bobkov V., Garcia J., Kiptily V. G., Schneider M., Wukitch S., Wright J. C., Dreval M., Kirov K. K., Mazzi S., Ochoukov R., Sharapov S. E., Weisen H., Baranov Y., Baruzzo M., Bierwage A., Bilato R., Chomiczewska A., Coelho R., Craciunescu T., Crombé K., Delabie E., Luna E. D. L., Dumont R., Dumortier P., Durodié F., Eriksson J., Fitzgerald M., Galdon-Quiroga J., Gallart D., Garcia-Munoz M., Giacomelli L., Giroud C., Gonzalez-Martin J., Hakola A., Henriques R., Jacquet P., Jepu I., Johnson T., Kappatou A., Keeling D., King D., Klepper C., Lauber P., Lennholm M., Lerche E., Lomanowski B., Lowry C., Mantsinen M. J., Maslov M., Menmuir S., Monakhov I., Nabais F., Nave M. F. F., Noble C., Panontin E., Pinches S. D., Polevoi A. R., Rigamonti D., Sahlberg A., Salewski M., Schneider P. A., Sheikh H., Shinohara K., Siren P., Sumida S., Thorman A., Tinguely R. A., Valcarcel D., Van Eester D., Schoor M. V., Varje J., Weiland M., Wendler N., Wukitch, SJ, Bertelli, N, Bonoli, P, Kazakov, Y, Ongena, J, Nocente, M, Bobkov, V, Garcia, J, Kiptily, V, Schneider, M, Wukitch, S, Wright, J, Dreval, M, Kirov, K, Mazzi, S, Ochoukov, R, Sharapov, S, Štancar, Weisen, H, Baranov, Y, Baruzzo, M, Bierwage, A, Bilato, R, Chomiczewska, A, Coelho, R, Craciunescu, T, Crombé, K, Delabie, E, Luna, E, Dumont, R, Dumortier, P, Durodié, F, Eriksson, J, Fitzgerald, M, Galdon-Quiroga, J, Gallart, D, Garcia-Munoz, M, Giacomelli, L, Giroud, C, Gonzalez-Martin, J, Hakola, A, Henriques, R, Jacquet, P, Jepu, I, Johnson, T, Kappatou, A, Keeling, D, King, D, Klepper, C, Lauber, P, Lennholm, M, Lerche, E, Lomanowski, B, Lowry, C, Mantsinen, M, Maslov, M, Menmuir, S, Monakhov, I, Nabais, F, Nave, M, Noble, C, Panontin, E, Pinches, S, Polevoi, A, Rigamonti, D, Sahlberg, A, Salewski, M, Schneider, P, Sheikh, H, Shinohara, K, Siren, P, Sumida, S, Thorman, A, Tinguely, R, Valcarcel, D, Van Eester, D, Schoor, M, Varje, J, Weiland, M, Wendler, N, Kazakov Y. O., Ongena J., Nocente M., Bobkov V., Garcia J., Kiptily V. G., Schneider M., Wukitch S., Wright J. C., Dreval M., Kirov K. K., Mazzi S., Ochoukov R., Sharapov S. E., Weisen H., Baranov Y., Baruzzo M., Bierwage A., Bilato R., Chomiczewska A., Coelho R., Craciunescu T., Crombé K., Delabie E., Luna E. D. L., Dumont R., Dumortier P., Durodié F., Eriksson J., Fitzgerald M., Galdon-Quiroga J., Gallart D., Garcia-Munoz M., Giacomelli L., Giroud C., Gonzalez-Martin J., Hakola A., Henriques R., Jacquet P., Jepu I., Johnson T., Kappatou A., Keeling D., King D., Klepper C., Lauber P., Lennholm M., Lerche E., Lomanowski B., Lowry C., Mantsinen M. J., Maslov M., Menmuir S., Monakhov I., Nabais F., Nave M. F. F., Noble C., Panontin E., Pinches S. D., Polevoi A. R., Rigamonti D., Sahlberg A., Salewski M., Schneider P. A., Sheikh H., Shinohara K., Siren P., Sumida S., Thorman A., Tinguely R. A., Valcarcel D., Van Eester D., Schoor M. V., Varje J., Weiland M., and Wendler N.

Abstract

The viability of magnetic confinement fusion as an energy source depends on achieving the high ion temperatures required for D-T fusion. Among the available techniques, plasma heating with waves in the ion cyclotron range of frequencies (ICRF) is a prominent method for bulk ion heating in fusion plasmas. Furthermore, a detailed understanding of the non-linear physics of alpha heating and the complex impact of MeV-range fast ions on plasma dynamics becomes progressively more important. This paper provides a comprehensive overview of recent developments with the three-ion ICRF scenarios on Alcator C-Mod, ASDEX Upgrade and JET tokamaks. The results demonstrate the flexibility of these novel scenarios for heating bulk ions in D-T ≈ 50%-50% plasmas and efficient generation of MeV-range fast ions in multi-ion species plasmas. Several key results relevant for ITER and future fusion reactors are highlighted.

Published
2023

75. On the Challenge of Plasma Heating with the JET Metallic Wall

Author

Mayoral, M-L, Bobkov, V, Czarnecka, A, Day, I, Ekedah, A, Jacquet, P, Goniche, M, King, R, Kirov, K, Lerche, E, Mailloux, J, Van Eester, D, Asunta, O, Challis, C, Ciric, D, Coenen, J W, Colas, L, Giroud, C, Graham, M, Jenkins, I, Joffrin, E, Jones, T, King, D, Kiptily, V, Klepper, C C, Maggi, C, Maggiora, R., Marcotte, F, Matthews, G, Milanesio, D, Monakhov, I, Nightingale, M, Neu, R, Ongena, J, Pütterich, T, Riccardo, V, Rimini, F, Strachan, J, Surrey, E, Thompson, V, Van Rooij, G, and contributors, JET EFDA

Subjects
Physics - Plasma Physics
Abstract

The major aspects linked to the use of the JET auxiliary heating systems: NBI, ICRF and LHCD, in the new JET ITER-like wall (JET-ILW) are presented. We show that although there were issues related to the operation of each system, efficient and safe plasma heating was obtained with room for higher power. For the NBI up to 25.7MW was safely injected; issues that had to be tackled were mainly the beam shine-through and beam re-ionisation before its entrance into the plasma. For the ICRF system, 5MW were coupled in L-mode and 4MW in H-mode; the main areas of concern were RF-sheaths related heat loads and impurities production. For the LH, 2.5 MW were delivered without problems; arcing and generation of fast electron beams in front of the launcher that can lead to high heat loads were the keys issues. For each system, an overview will be given of: the main modifications implemented for safe use, their compatibility with the new metallic wall, the differences in behavior compared with the previous carbon wall, with emphasis on heat loads and impurity content in the plasma., Comment: 21 pages, 17 figures

Published
2013
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76. Reconnaissance of the HR 8799 Exosolar System I: Near IR Spectroscopy

Author

Oppenheimer, B. R., Baranec, C., Beichman, C., Brenner, D., Burruss, R., Cady, E., Crepp, J. R., Dekany, R., Fergus, R., Hale, D., Hillenbrand, L., Hinkley, S., Hogg, David W., King, D., Ligon, E. R., Lockhart, T., Nilsson, R., Parry, I. R., Pueyo, L., Rice, E., Roberts, J. E., Roberts, Jr., L. C., Shao, M., Sivaramakrishnan, A., Soummer, R., Truong, T., Vasisht, G., Veicht, A., Vescelus, F., Wallace, J. K., Zhai, C., and Zimmerman, N.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

We obtained spectra, in the wavelength range \lambda = 995 - 1769 nm, of all four known planets orbiting the star HR 8799. Using the suite of instrumentation known as Project 1640 on the Palomar 5-m Hale Telescope, we acquired data at two epochs. This allowed for multiple imaging detections of the companions and multiple extractions of low-resolution (R ~ 35) spectra. Data reduction employed two different methods of speckle suppression and spectrum extraction, both yielding results that agree. The spectra do not directly correspond to those of any known objects, although similarities with L and T-dwarfs are present, as well as some characteristics similar to planets such as Saturn. We tentatively identify the presence of CH_4 along with NH_3 and/or C_2H_2, and possibly CO_2 or HCN in varying amounts in each component of the system. Other studies suggested red colors for these faint companions, and our data confirm those observations. Cloudy models, based on previous photometric observations, may provide the best explanation for the new data presented here. Notable in our data is that these presumably co-eval objects of similar luminosity have significantly different spectra; the diversity of planets may be greater than previously thought. The techniques and methods employed in this paper represent a new capability to observe and rapidly characterize exoplanetary systems in a routine manner over a broad range of planet masses and separations. These are the first simultaneous spectroscopic observations of multiple planets in a planetary system other than our own., Comment: Accepted for publication in The Astrophysical Journal 8 March 2013. Submitted 12 November 2012. Revised 11 February 2013 and 7 March 2013. 19 Pages, 10 Figures. Figure 4 is the money plot

Published
2013
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77. Improving breast self-examination compliance: a Southwest Oncology Group randomized trial of three interventions.

Author

Strickland, C J, Feigl, P, Upchurch, C, King, D K, Pierce, H I, Grevstad, P K, Bearden, J D, 3rd, Dawson, M, Loewen, W C, and Meyskens, F L, Jr

Subjects
Adult, Age Factors, Attitude to Health, Breast Neoplasms: prevention & control, psychology, Breast Self-Examination: statistics & numerical data, Chi-Square Distribution, Female, Health Education: methods, standards, Humans, Intervention Studies, Logistic Models, Middle Aged, Multivariate Analysis, Patient Compliance, Patient Dropouts, Physician's Role, Program Evaluation, Prospective Studies, Psychological Theory, Reinforcement (Psychology), Treatment Outcome, United States, Women's Health, breast self-examination and physicians, breast self-examination and reinforcement, breast self-examination and training, health education, patient complianceadult, article, breast cancer, breast examination, controlled study, female, health education, human, normal human, patient compliance, patient education, priority journal, reinforcement, self examination, Adult, Age Factors, Attitude to Health, Breast Neoplasms, Breast Self-Examination, Chi-Square Distribution, Female, Health Education, Humans, Intervention Studies, Logistic Models, Middle Aged, Multivariate Analysis, Patient Compliance, Patient Dropouts, Physician's Role, Program Evaluation, Prospective Studies, Psychological Theory, Reinforcement (Psychology), Treatment Outcome, United States, Women's Health
Abstract

Only 20-40% of U.S. women conduct breast self-examination (BSE). This Southwest Oncology Group experimental study compared the impact of three interventions on BSE compliance.Subjects were randomly assigned to one of three arms: (1) physician message; (2) physician message and BSE class; or (3) physician message, BSE class, and reinforcement (phone and postcard). Compliance (frequency and accuracy) was measured by interview at intake and at 6 months and by phone contact at 1 year. Logistic and multiple regression were employed.This analysis included 2,233 subjects from six institutions. At 1 year the percentages of women doing BSE were 59, 62, and 78% for Arms 1-3, respectively; gains over intake frequency (27% average) were significant within each arm (P < or = 0.0001). At both 6 months and 1 year the differences between Arm 1 and Arm 2 average accuracy scores and the differences between Arm 2 and Arm 3 in the percentage of women doing BSE were significant (P < or = 0.0001). Findings within institutions were consistent with the overall findings.The addition of a BSE class increased accuracy over physician message alone; physician message, BSE class, and reinforcement gave the highest percentage of women doing BSE.

Published
2014

84. A Technology-Informed Approach to Clinical Trial Equity

Author

Brown, E., primary, Jr, G. A. Fisher, additional, Shelton, A., additional, Johnson, T., additional, Chen, C., additional, Shaheen, S., additional, Holden, T.L., additional, Dao, V.A., additional, Bien, J.Y.E., additional, King, D., additional, Vitzthum, L., additional, Kirilcuk, N., additional, Morris, A., additional, Kin, C., additional, Dawes, A., additional, Sheth, V., additional, Chang, D.T., additional, and Pollom, E., additional

Published
2023
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85. Extracellular Perinexal Separation Is a Principal Determinant of Cardiac Conduction

Author

Adams, William P., primary, Raisch, Tristan B., additional, Zhao, Yajun, additional, Davalos, Rafael, additional, Barrett, Sarah, additional, King, D. Ryan, additional, Bain, Chandra B., additional, Colucci-Chang, Katrina, additional, Blair, Grace A., additional, Hanlon, Alexandra, additional, Lozano, Alicia, additional, Veeraraghavan, Rengasayee, additional, Wan, Xiaoping, additional, Deschenes, Isabelle, additional, Smyth, James W., additional, Hoeker, Gregory S., additional, Gourdie, Robert G., additional, and Poelzing, Steven, additional

Published
2023
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88. Comparison of Machine Learning Algorithms for Predictive Modeling of Beef Attributes Using Rapid Evaporative Ionization Mass Spectrometry (REIMS) Data *

Author

Gredell, Devin A., primary, Schroeder, Amelia R., additional, Belk, Keith E., additional, Broeckling, Corey D., additional, Heuberger, Adam L., additional, Kim, Soo-Young, additional, King, D. Andy, additional, Shackelford, Steven D., additional, Sharp, Julia L., additional, Wheeler, Tommy L., additional, Woerner, Dale R., additional, and Prenni, Jessica E., additional

Published
2020
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91. Towards a swarm robotic approach for cooperative object recognition

Author

King, D.

Subjects
629.8
Abstract

Social insects have inspired the behaviours of swarm robotic systems for the last 20 years. Interactions of the simple individuals in these swarms form solutions to relatively complex problems. A novel swarm robotic method is investigated for future robotic cooperative object recognition tasks. Previous multi-agent systems involve cameras and image analyses to identify objects. They cooperate only to improve their hypotheses of the shape's identity. The system proposed uses agents whose interactions with each other around the physical boundaries of the object's shape allow the distinguishing features found. The agents are a physical embodiment of the vision system, making them suitable for environments where it would not be possible to use a camera. A Simplified Hexagonal Model was developed to simulate and examine the strategies. The hexagonal cells of which can be empty, contain an agent (hBot) or part of an object shape. Initially the hBots are required to identify the valid object shapes from a set of two types of known shapes. To do this the hBots change state when in contact with an object and when touching other hBots of the same state level, where some states are only achieved when neighbouring certain object shapes. The agents are oblivious, anonymous and homogeneous. They also do not know their position or orientation and cannot distinguish between object shapes alone due to their limited sensor range. Further work increased the number of object shapes to provide a range of scenarios. In order to hypothesise the difficulty a swarm of hBots has distinguishing one object shape type from any other a system is devised to compare object shapes. Data-chains describe the object shapes, without orientation, by considering how many object cells the empty cells surrounding them are in contact with. Pairs of object shapes could then be analysed to determine their difference value from each other. These difference values correlate to a swarms difficulty in completing the specific scenarios. Finally, a genetic algorithm (GA) was analysed as a method to determine the behaviours of the hBots different states. The GA is more efficient than both derived and randomly populated methods, showing that a GA can be used to train agents without first determining differences between the object shapes. These insights provide a significant contribution to knowledge through the object shape analyses method and the swarm robotic strategies which establish a unique foundation for further development of novel applications for both swarm robotic and cooperative object recognition research.

Published
2012

92. Successful Community College Election Strategies.

Author

King, D. Brian

Abstract

This study identifies successful election strategies employed by community colleges in bond issues or tax levy increase elections, and distills these strategies into a list of principles or rules that can be utilized by colleges in preparing for such an event. Results of case studies conducted at Maricopa (Arizona), Santa Monica (California), and Washtenaw (Michigan) community colleges indicate that: (1) dollars raised by campaigns are not enough to guarantee victory; (2) each campaign had significant support from a broad array of community organizations; (3) the length of the formal campaign was relatively brief for all three subject colleges; (4) the impact of other, unrelated issues on the same ballot differs by college; (5) the primary organization of each campaign came from a core of college staff members; (6) efforts to involve students in the campaign efforts were emphasized; (7) staff participation at the colleges were crucial to electoral success; (8) efforts to involve faculty and staff began years before the formal campaign; (9) strengths and weaknesses were assessed by the subject colleges both internally and externally; and (10) the primary role of the formal campaign committees was to raise dollars for the advocacy effort of the campaigns. Each of the colleges studied had an electoral victory; further research on colleges that lost elections might provide a useful comparative analysis. Appended are the questionnaire provided to state community college directors, the fifty-state telephone survey, the follow-up questionnaire to subject colleges, the interview guide and procedures, a summary of contacts in fifty-state telephone survey, summaries of interviews, ballot language, and employee guidelines for bond election. Contains five tables and 114 references. (AS)

Published
1998

93. Determining carrier densities in InMnAs by cyclotron resonance

Author

Sanders, G. D., Sun, Y., Stanton, C. J., Khodaparast, G. A., Kono, J., King, D. S., Matsuda, Y. H., Ikeda, S., Miura, N., Oiwa, A., and Munekata, H.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

Accurate determination of carrier densities in ferromagnetic semiconductors by Hall measurements is hindered by the anomalous Hall effect, and thus alternative methods are being sought. Here, we propose that cyclotron resonance (CR) is an excellent method for carrier density determination for InMnAs-based magnetic structures. We develop a theory for electronic and magneto-optical properties in narrow gap InMnAs films and superlattices in ultrahigh magnetic fields oriented along [001]. In n-type InMnAs films and superlattices, we find that the e-active CR peak field is pinned at low electron densities and then begins to shift rapidly to higher fields above a critical electron concentration allowing the electron density to be accurately calibrated. In p-type InMnAs, we observe two h-active CR peaks due to heavy and light holes. The lineshapes depend on temperature and line broadening. The light hole CR requires higher hole densities and fields. Analyzing CR lineshapes in p-films and superlattices can help determine hole densities., Comment: 4 pages, 4 figures

Published
2003
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