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52. Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses

Author

Yudi Zhang, Volker Kinast, Julie Sheldon, Nicola Frericks, Daniel Todt, Matthias Zimmer, Neva Caliskan, Richard J. P. Brown, Eike Steinmann, and Thomas Pietschmann

Subjects
restriction factor, HCV, liver, IFN, species tropism, virus, Microbiology, QR1-502
Abstract

ABSTRACT Mice are refractory to infection with human-tropic hepatitis C virus (HCV), although distantly related rodent hepaciviruses (RHV) circulate in wild rodents. To investigate whether liver intrinsic host factors can exhibit broad restriction against these distantly related hepaciviruses, we focused on Shiftless (Shfl), an interferon (IFN)-regulated gene (IRG) which restricts HCV in humans. Unusually, and in contrast to selected classical IRGs, human and mouse SHFL orthologues (hSHFL and mSHFL, respectively) were highly expressed in hepatocytes in the absence of viral infection, weakly induced by IFN, and highly conserved at the amino acid level (>95%). Replication of both HCV and RHV subgenomic replicons was suppressed by ectopic expression of mSHFL in human or rodent hepatoma cell lines. Gene editing of endogenous mShfl in mouse liver tumor cells increased HCV replication and virion production. Colocalization of mSHFL protein with viral double-stranded RNA (dsRNA) intermediates was confirmed and could be ablated by mutational disruption of the SHFL zinc finger domain, concomitant with a loss of antiviral activity. In summary, these data point to an evolutionarily conserved function for this gene in humans and rodents: SHFL is an ancient antiviral effector which targets distantly related hepaciviruses via restriction of viral RNA replication. IMPORTANCE Viruses have evolved ways to evade or blunt innate cellular antiviral mechanisms within their cognate host species. However, these adaptations may fail when viruses infect new species and can therefore limit cross-species transmission. This may also prevent development of animal models for human-pathogenic viruses. HCV shows a narrow species tropism likely due to distinct human host factor usage and innate antiviral defenses limiting infection of nonhuman liver cells. Interferon (IFN)-regulated genes (IRGs) partially inhibit HCV infection of human cells by diverse mechanisms. Here, we show that mouse Shiftless (mSHFL), a protein that interferes with HCV replication factories, inhibits HCV replication and infection in human and mouse liver cells. We further report that the zinc finger domain of SHFL is important for viral restriction. These findings implicate mSHFL as a host factor that impairs HCV infection of mice and provide guidance for development of HCV animal models needed for vaccine development.

Published
2023
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53. Geant4-based electromagnetic background model for the CRESST dark matter experiment

Author

CRESST Collaboration, Abdelhameed, A. H., Angloher, G., Bauer, P., Bento, A., Bertoldo, E., Breier, R., Bucci, C., Canonica, L., D'Addabbo, A., Di Lorenzo, S., Erb, A., Feilitzsch, F. v., Iachellini, N. Ferreiro, Fichtinger, S., Fuss, A., Gorla, P., Hauff, D., Ješkovský, M., Jochum, J., Kaizer, J., Kinast, A., Kluck, H., Kraus, H., Langenkämper, A., Mancuso, M., Mokina, V., Mondragón, E., Olmi, M., Ortmann, T., Pagliarone, C., Palušová, V., Pattavina, L., Petricca, F., Potzel, W., Povinec, P., Pröbst, F., Reindl, F., Rothe, J., Schäffner, K., Schieck, J., Schipperges, V., Schmiedmayer, D., Schönert, S., Schwertner, C., Stahlberg, M., Stodolsky, L., Strandhagen, C., Strauss, R., Türkoğlu, C., Usherov, I., Willers, M., Zema, V., and Zeman, J.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The CRESST (Cryogenic Rare Event Search with Superconducting Thermometers) dark matter search experiment aims for the detection of dark matter particles via elastic scattering off nuclei in $\mathrm{CaWO_4}$ crystals. To understand the CRESST electromagnetic background due to the bulk contamination in the employed materials, a model based on Monte Carlo simulations was developed using the Geant4 simulation toolkit. The results of the simulation are applied to the TUM40 detector module of CRESST-II phase 2. We are able to explain up to $(68 \pm 16)\,\mathrm{\%}$ of the electromagnetic background in the energy range between $1\,\mathrm{keV}$ and $40\,\mathrm{keV}$., Comment: 19 pages, 12 figures

Published
2019
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54. Exploring CEvNS with NUCLEUS at the Chooz Nuclear Power Plant

Author

Angloher, G., Ardellier-Desages, F., Bento, A., Canonica, L., Erhart, A., Ferreiro, N., Friedl, M., Ghete, V. M., Hauff, D., Kluck, H., Langenkämper, A., Lasserre, T., Lhuillier, D., Kinast, A., Mancuso, M., Rubiales, J. Molina, Mondragon, E., Munch, G., Nones, C., Oberauer, L., Onillon, A., Ortmann, T., Pattavina, L., Petricca, F., Potzel, W., Pröbst, F., Reindl, F., Rothe, J., Schieck, J., Schönert, S., Schwertner, C., Scola, L., Stodolsky, L., Strauss, R., Vivier, M., Wagner, V., and Zolotarova, A.

Subjects
Physics - Instrumentation and Detectors
Abstract

Coherent elastic neutrino-nucleus scattering (CE$\nu$NS) offers a unique way to study neutrino properties and to search for new physics beyond the Standard Model. Nuclear reactors are promising sources to explore this process at low energies since they deliver large fluxes of (anti-)neutrinos with typical energies of a few MeV. In this paper, a new-generation experiment to study CE$\nu$NS is described. The NUCLEUS experiment will use cryogenic detectors which feature an unprecedentedly low energy threshold and a time response fast enough to be operated in above-ground conditions. Both sensitivity to low-energy nuclear recoils and a high event rate tolerance are stringent requirements to measure CE$\nu$NS of reactor antineutrinos. A new experimental site, denoted the Very-Near-Site (VNS) at the Chooz nuclear power plant in France is described. The VNS is located between the two 4.25 GW$_{\mathrm{th}}$ reactor cores and matches the requirements of NUCLEUS. First results of on-site measurements of neutron and muon backgrounds, the expected dominant background contributions, are given. In this paper a preliminary experimental setup with dedicated active and passive background reduction techniques is presented. Furthermore, the feasibility to operate the NUCLEUS detectors in coincidence with an active muon-veto at shallow overburden is studied. The paper concludes with a sensitivity study pointing out the promising physics potential of NUCLEUS at the Chooz nuclear power plant.

Published
2019
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55. Description of CRESST-III Data

Author

CRESST Collaboration, Abdelhameed, A. H., Angloher, G., Bauer, P., Bento, A., Bertoldo, E., Bucci, C., Canonica, L., D'Addabbo, A., Defay, X., Di Lorenzo, S., Erb, A., Feilitzsch, F. v., Fichtinger, S., Iachellini, N. Ferreiro, Fuss, A., Gorla, P., Hauff, D., Jochum, J., Kinast, A., Kluck, H., Kraus, H., Langenkämper, A., Mancuso, M., Mokina, V., Mondragon, E., Münster, A., Olmi, M., Ortmann, T., Pagliarone, C., Pattavina, L., Petricca, F., Potzel, W., Pröbst, F., Reindl, F., Rothe, J., Schäffner, K., Schieck, J., Schipperges, V., Schmiedmayer, D., Schönert, S., Schwertner, C., Stahlberg, M., Stodolsky, L., Strandhagen, C., Strauss, R., Türkoglu, C., Usherov, I., Willers, M., and Zema, V.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

In CRESST-III, 10 cryogenic detector modules optimized for low energy thresholds were operated for almost two years (May 2016 - February 2018). Together with this document we are publishing data from the best performing detector module which has a nuclear recoil threshold of 30.1eV. With this data-set we were able to set limits on the cross-section for spin-dependent and spin-independent elastic scattering of dark matter particles off nuclei at dark matter masses down to 160MeV/c$^2$. We publish the energies of all events after data selection as well as of all events within the acceptance region for dark-matter searches. In this document we describe how to use these data sets., Comment: Added appendix with information for better reproducibility

Published
2019

56. First results from the CRESST-III low-mass dark matter program

Author

CRESST Collaboration, Abdelhameed, A. H., Angloher, G., Bauer, P., Bento, A., Bertoldo, E., Bucci, C., Canonica, L., D'Addabbo, A., Defay, X., Di Lorenzo, S., Erb, A., Feilitzsch, F. v., Fichtinger, S., Iachellini, N. Ferreiro, Fuss, A., Gorla, P., Hauff, D., Jochum, J., Kinast, A., Kluck, H., Kraus, H., Langenkämper, A., Mancuso, M., Mokina, V., Mondragon, E., Münster, A., Olmi, M., Ortmann, T., Pagliarone, C., Pattavina, L., Petricca, F., Potzel, W., Pröbst, F., Reindl, F., Rothe, J., Schäffner, K., Schieck, J., Schipperges, V., Schmiedmayer, D., Schönert, S., Schwertner, C., Stahlberg, M., Stodolsky, L., Strandhagen, C., Strauss, R., Türkoglu, C., Usherov, I., Willers, M., and Zema, V.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The CRESST experiment is a direct dark matter search which aims to measure interactions of potential dark matter particles in an earth-bound detector. With the current stage, CRESST-III, we focus on a low energy threshold for increased sensitivity towards light dark matter particles. In this manuscript we describe the analysis of one detector operated in the first run of CRESST-III (05/2016-02/2018) achieving a nuclear recoil threshold of 30.1eV. This result was obtained with a 23.6g CaWO$_4$ crystal operated as a cryogenic scintillating calorimeter in the CRESST setup at the Laboratori Nazionali del Gran Sasso (LNGS). Both the primary phonon/heat signal and the simultaneously emitted scintillation light, which is absorbed in a separate silicon-on-sapphire light absorber, are measured with highly sensitive transition edge sensors operated at ~15mK. The unique combination of these sensors with the light element oxygen present in our target yields sensitivity to dark matter particle masses as low as 160MeV/c$^2$., Comment: 9 pages, 9 figures

Published
2019
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57. First results on sub-GeV spin-dependent dark matter interactions with $^{7}$Li

Author

Abdelhameed, A. H., Angloher, G., Bauer, P., Bento, A., Bertoldo, E., Bucci, C., Canonica, L., D'Addabbo, A., Defay, X., Di Lorenzo, S., Erb, A., Feilitzsch, F. v., Iachellini, N. Ferreiro, Fichtinger, S., Fuss, A., Gorla, P., Hauff, D., Jochum, J., Kinast, A., Kluck, H., Kraus, H., Langenkämper, A., Mancuso, M., Mokina, V., Mondragon, E., Münster, A., Olmi, M., Ortmann, T., Pagliarone, C., Pattavina, L., Petricca, F., Potzel, W., Pröbst, F., Reindl, F., Rothe, J., Schäffner, K., Schieck, J., Schipperges, V., Schmiedmayer, D., Schönert, S., Schwertner, C., Stahlberg, M., Stodolsky, L., Strandhagen, C., Strauss, R., Türkoglu, C., Usherov, I., Willers, M., Zema, V., Chapellier, M., Giuliani, A., Nones, C., Poda, D. V., Shlegel, V. N., Velázquez, M., and Zolotarova, A. S.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

In this work, we want to highlight the potential of lithium as a target for spin-dependent dark matter search in cryogenic experiments, with a special focus on the low-mass region of the parameter space. We operated a prototype detector module based on a Li$_2$MoO$_4$ target crystal in an above-ground laboratory. Despite the high background environment, the detector sets competitive limits on spin-dependent interactions of dark matter particles with protons and neutrons for masses between 0.8 GeV/c$^2$ and 1.5 GeV/c$^2$.

Published
2019
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59. Secular equilibrium assessment in a CaWO4 target crystal from the dark matter experiment CRESST using Bayesian likelihood normalisation

Author

Angloher, G., Banik, S., Benato, G., Bento, A., Bertolini, A., Breier, R., Bucci, C., Burkhart, J., Canonica, L., D’Addabbo, A., Di Lorenzo, S., Einfalt, L., Erb, A., Feilitzsch, F.v., Ferreiro Iachellini, N., Fichtinger, S., Fuchs, D., Fuss, A., Garai, A., Ghete, V.M., Gorla, P., Gupta, S., Hauff, D., Ješkovský, M., Jochum, J., Kaznacheeva, M., Kinast, A., Kluck, H., Kraus, H., Langenkämper, A., Mancuso, M., Marini, L., Mokina, V., Nilima, A., Olmi, M., Ortmann, T., Pagliarone, C., Pattavina, L., Petricca, F., Potzel, W., Povinec, P., Pröbst, F., Pucci, F., Reindl, F., Rothe, J., Schäffner, K., Schieck, J., Schmiedmayer, D., Schönert, S., Schwertner, C., Stahlberg, M., Stodolsky, L., Strandhagen, C., Strauss, R., Usherov, I., Wagner, F., Willers, M., Zema, V., Ferella, F., Laubenstein, M., and Nisi, S.

Published
2023
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62. Towards an automated data cleaning with deep learning in CRESST

Author

Angloher, G., Banik, S., Bartolot, D., Benato, G., Bento, A., Bertolini, A., Breier, R., Bucci, C., Burkhart, J., Canonica, L., D’Addabbo, A., Di Lorenzo, S., Einfalt, L., Erb, A., Feilitzsch, F. v., Iachellini, N. Ferreiro, Fichtinger, S., Fuchs, D., Fuss, A., Garai, A., Ghete, V. M., Gerster, S., Gorla, P., Guillaumon, P. V., Gupta, S., Hauff, D., Ješkovský, M., Jochum, J., Kaznacheeva, M., Kinast, A., Kluck, H., Kraus, H., Lackner, M., Langenkämper, A., Mancuso, M., Marini, L., Meyer, L., Mokina, V., Nilima, A., Olmi, M., Ortmann, T., Pagliarone, C., Pattavina, L., Petricca, F., Potzel, W., Povinec, P., Pröbst, F., Pucci, F., Reindl, F., Rizvanovic, D., Rothe, J., Schäffner, K., Schieck, J., Schmiedmayer, D., Schönert, S., Schwertner, C., Stahlberg, M., Stodolsky, L., Strandhagen, C., Strauss, R., Usherov, I., Wagner, F., Willers, M., Zema, V., and Waltenberger, W.

Published
2023
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63. OS-092 Targeting cellular cathepsins inhibits hepatitis E virus infection

Author

Klöhn, Mara, primary, Burkard, Thomas, additional, Janzen, Juliana, additional, Schrader, Jil Alexandra, additional, Gömer, André, additional, Brown, Richard, additional, Fu, Rebecca, additional, Thi, Viet Loan Dao, additional, Kinast, Volker, additional, Brüggemann, Yannick, additional, Todt, Daniel, additional, and Steinmann, Eike, additional

Published
2024
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64. Targeting cellular cathepsins inhibits hepatitis E virus entry

Author

Klöhn, Mara, primary, Burkard, Thomas, additional, Janzen, Juliana, additional, Haase, Jil Alexandra, additional, Gömer, André, additional, Fu, Rebecca, additional, Ssebyatika, George, additional, Nocke, Maximilian K., additional, Brown, Richard J. P., additional, Krey, Thomas, additional, Dao Thi, Viet Loan, additional, Kinast, Volker, additional, Brüggemann, Yannick, additional, Todt, Daniel, additional, and Steinmann, Eike, additional

Published
2024
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65. Theoretical compensation of static deformations of freeform multi mirror substrates

Author

Hartung, Johannes, von Lukowicz, Henrik, and Kinast, Jan

Subjects
Physics - Applied Physics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Varying temperatures influence the figure errors of freeform metal mirrors by thermal expansion. Furthermore, different materials lead to thermo-elastic bending effects. The article presents a derivation of a compensation approach for general static loads. Utilizing perturbation theory this approach works for shape compensation of substrates which operate in various temperature environments. Verification is made using a finite element analysis which is further used to produce manufacturable CAD models. The remaining low spatial frequency errors are deterministically correctable using diamond turning or polishing techniques., Comment: 16 pages, published version

Published
2018
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71. Functional Requirements for Medical Data Integration into Knowledge Management Environments: Requirements Elicitation Approach Based on Systematic Literature Analysis

Author

Benjamin Kinast, Hannes Ulrich, Björn Bergh, and Björn Schreiweis

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundIn patient care, data are historically generated and stored in heterogeneous databases that are domain specific and often noninteroperable or isolated. As the amount of health data increases, the number of isolated data silos is also expected to grow, limiting the accessibility of the collected data. Medical informatics is developing ways to move from siloed data to a more harmonized arrangement in information architectures. This paradigm shift will allow future research to integrate medical data at various levels and from various sources. Currently, comprehensive requirements engineering is working on data integration projects in both patient care– and research-oriented contexts, and it is significantly contributing to the success of such projects. In addition to various stakeholder-based methods, document-based requirement elicitation is a valid method for improving the scope and quality of requirements. ObjectiveOur main objective was to provide a general catalog of functional requirements for integrating medical data into knowledge management environments. We aimed to identify where integration projects intersect to derive consistent and representative functional requirements from the literature. On the basis of these findings, we identified which functional requirements for data integration exist in the literature and thus provide a general catalog of requirements. MethodsThis work began by conducting a literature-based requirement elicitation based on a broad requirement engineering approach. Thus, in the first step, we performed a web-based systematic literature review to identify published articles that dealt with the requirements for medical data integration. We identified and analyzed the available literature by applying the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. In the second step, we screened the results for functional requirements using the requirements engineering method of document analysis and derived the requirements into a uniform requirement syntax. Finally, we classified the elicited requirements into a category scheme that represents the data life cycle. ResultsOur 2-step requirements elicitation approach yielded 821 articles, of which 61 (7.4%) were included in the requirement elicitation process. There, we identified 220 requirements, which were covered by 314 references. We assigned the requirements to different data life cycle categories as follows: 25% (55/220) to data acquisition, 35.9% (79/220) to data processing, 12.7% (28/220) to data storage, 9.1% (20/220) to data analysis, 6.4% (14/220) to metadata management, 2.3% (5/220) to data lineage, 3.2% (7/220) to data traceability, and 5.5% (12/220) to data security. ConclusionsThe aim of this study was to present a cross-section of functional data integration–related requirements defined in the literature by other researchers. The aim was achieved with 220 distinct requirements from 61 publications. We concluded that scientific publications are, in principle, a reliable source of information for functional requirements with respect to medical data integration. Finally, we provide a broad catalog to support other scientists in the requirement elicitation phase.

Published
2023
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73. Probing spin-dependent dark matter interactions with $$^6$$ 6 Li

Author

G. Angloher, G. Benato, A. Bento, E. Bertoldo, A. Bertolini, R. Breier, C. Bucci, L. Canonica, A. D’Addabbo, S. Di Lorenzo, L. Einfalt, A. Erb, F. v. Feilitzsch, N. Ferreiro Iachellini, S. Fichtinger, D. Fuchs, A. Fuss, A. Garai, V. M. Ghete, P. Gorla, S. Gupta, D. Hauff, M. Ješkovský, J. Jochum, M. Kaznacheeva, A. Kinast, H. Kluck, H. Kraus, A. Langenkämper, M. Mancuso, L. Marini, V. Mokina, A. Nilima, M. Olmi, T. Ortmann, C. Pagliarone, V. Palušová, L. Pattavina, F. Petricca, W. Potzel, P. Povinec, F. Pröbst, F. Pucci, F. Reindl, J. Rothe, K. Schäffner, J. Schieck, D. Schmiedmayer, S. Schönert, C. Schwertner, M. Stahlberg, L. Stodolsky, C. Strandhagen, R. Strauss, I. Usherov, F. Wagner, M. Willers, and V. Zema

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract CRESST is one of the most prominent direct detection experiments for dark matter particles with sub-GeV/c $$^2$$ 2 mass. One of the advantages of the CRESST experiment is the possibility to include a large variety of nuclides in the target material used to probe dark matter interactions. In this work, we discuss in particular the interactions of dark matter particles with protons and neutrons of $$^{6}$$ 6 Li. This is now possible thanks to new calculations on nuclear matrix elements of this specific isotope of Li. To show the potential of using this particular nuclide for probing dark matter interactions, we used the data collected previously by a CRESST prototype based on LiAlO $$_2$$ 2 and operated in an above ground test-facility at Max-Planck-Institut für Physik in Munich, Germany. In particular, the inclusion of $$^{6}$$ 6 Li in the limit calculation drastically improves the result obtained for spin-dependent interactions with neutrons in the whole mass range. The improvement is significant, greater than two order of magnitude for dark matter masses below 1 GeV/c $$^2$$ 2 , compared to the limit previously published with the same data.

Published
2022
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76. Medical Data Engineering – Theory and Practice

Author

Kock-Schoppenhauer, Ann-Kristin, Schreiweis, Björn, Ulrich, Hannes, Reimer, Niklas, Wiedekopf, Joshua, Kinast, Benjamin, Busch, Hauke, Bergh, Björn, Ingenerf, Josef, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Bellatreche, Ladjel, editor, Chernishev, George, editor, Corral, Antonio, editor, Ouchani, Samir, editor, and Vain, Jüri, editor

Published
2021
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78. The triglyceride-synthesizing enzyme diacylglycerol acyltransferase 2 modulates the formation of the hepatitis C virus replication organelle.

Author

Reichert, Isabelle, Lee, Ji-Young, Weber, Laura, Fuh, Marceline M., Schlaeger, Lina, Rößler, Stefanie, Kinast, Volker, Schlienkamp, Sarah, Conradi, Janina, Vondran, Florian W. R., Pfaender, Stephanie, Scaturro, Pietro, Steinmann, Eike, Bartenschlager, Ralf, Pietschmann, Thomas, Heeren, Joerg, Lauber, Chris, and Vieyres, Gabrielle

Subjects
HEPATITIS C virus, UNSATURATED fatty acids, INTRACELLULAR membranes, ENDOPLASMIC reticulum, HEPATITIS C
Abstract

The replication organelle of hepatitis C virus (HCV), called membranous web, is derived from the endoplasmic reticulum (ER) and mainly comprises double membrane vesicles (DMVs) that concentrate the viral replication complexes. It also tightly associates with lipid droplets (LDs), which are essential for virion morphogenesis. In particular acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), a rate-limiting enzyme in triglyceride synthesis, promotes early steps of virus assembly. The close proximity between ER membranes, DMVs and LDs therefore permits the efficient coordination of the HCV replication cycle. Here, we demonstrate that exaggerated LD accumulation due to the excessive expression of the DGAT1 isozyme, DGAT2, dramatically impairs the formation of the HCV membranous web. This effect depended on the enzymatic activity and ER association of DGAT2, whereas the mere LD accumulation was not sufficient to hamper HCV RNA replication. Our lipidomics data indicate that both HCV infection and DGAT2 overexpression induced membrane lipid biogenesis and markedly increased phospholipids with long chain polyunsaturated fatty acids, suggesting a dual use of these lipids and their possible competition for LD and DMV biogenesis. On the other hand, overexpression of DGAT2 depleted specific phospholipids, particularly oleyl fatty acyl chain-containing phosphatidylcholines, which, in contrast, are increased in HCV-infected cells and likely essential for viral infection. In conclusion, our results indicate that lipid exchanges occurring during LD biogenesis regulate the composition of intracellular membranes and thereby affect the formation of the HCV replication organelle. The potent antiviral effect observed in our DGAT2 overexpression system unveils lipid flux that may be relevant in the context of steatohepatitis, a hallmark of HCV infection, but also in physiological conditions, locally in specific subdomains of the ER membrane. Thus, LD formation mediated by DGAT1 and DGAT2 might participate in the spatial compartmentalization of HCV replication and assembly factories within the membranous web. Author summary: Lipid droplets are fat storage organelles with an increasingly recognized importance for the infectious cycle of multiple pathogens. In particular, they support hepatitis C virion morphogenesis and the formation of the picornaviral replication organelle. Unexpectedly, we observed that exaggerated lipid droplet biogenesis, due to an excessive expression of the triglyceride forming enzyme DGAT2, is deleterious to hepatitis C virus replication. More precisely, the formation and maintenance of the viral replication organelle was impeded. Exaggerated lipid droplet biogenesis induced by DGAT2 also profoundly altered the cell lipidome, with strong accumulation of neutral lipids and changes in the membrane lipid composition. Our results support a model where lipid flux occurring during lipid droplet biogenesis regulates the composition of the endoplasmic reticulum membranes, where lipid droplets are formed, and thereby affect the capacity of hepatitis C virus to remodel these membranes into its replication organelle. Since DGAT1 and its triglyceride synthesis were previously reported to contribute to virus assembly, this also implies that lipid droplet biogenesis driven by DGAT1 and DGAT2 but also membrane contact sites between endoplasmic reticulum and lipid droplets might locally restrict and determine the formation of hepatitis C virus replication and assembly factories. [ABSTRACT FROM AUTHOR]

Published
2024
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79. Latest observations on the low energy excess in CRESST-III

Author

G. Angloher, S. Banik, G. Benato, A. Bento, A. Bertolini, R. Breier, C. Bucci, L. Canonica, A. D'Addabbo, S. Di Lorenzo, L. Einfalt, A. Erb, F. von Feilitzsch, N. Ferreiro Iachellini, S. Fichtinger, D. Fuchs, A. Fuss, A. Garai, V. M. Ghete, S. Gerster, P. Gorla, P. V. Guillaumon, S. Gupta, D. Hauff, M. Ješkovský, J. Jochum, M. Kaznacheeva, A. Kinast, H. Kluck, H. Kraus, A. Langenkämper, M. Mancuso, L. Marini, L. Meyer, V. Mokina, A. Nilima, M. Olmi, T. Ortmann, C. Pagliarone, L. Pattavina, F. Petricca, W. Potzel, P. Povinec, F. Pröbst, F. Pucci, F. Reindl, J. Rothe, K. Schäffner, J. Schieck, D. Schmiedmayer, S. Schönert, C. Schwertner, M. Stahlberg, L. Stodolsky, C. Strandhagen, R. Strauss, I. Usherov, F. Wagner, M. Willers, V. Zema

Subjects
Physics, QC1-999
Abstract

The CRESST experiment observes an unexplained excess of events at low energies. In the current CRESST-III data-taking campaign we are operating detector modules with different designs to narrow down the possible explanations. In this work, we show first observations of the ongoing measurement, focusing on the comparison of time, energy and temperature dependence of the excess in several detectors. These exclude dark matter, radioactive backgrounds and intrinsic sources related to the crystal bulk as a major contribution.

Published
2023
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80. Exploring coherent elastic neutrino-nucleus scattering of reactor neutrinos with the NUCLEUS experiment

Author

C. Goupy, H. Abele, G. Angloher, A. Bento, L. Canonica, F. Cappella, L. Cardani, N. Casali, R. Cerulli, I. Colantoni, A. Cruciani, G. del Castello, M. del Gallo Roccagiovine, A. Doblhammer, S. Dorer, A. Erhart, M. Friendl, A. Garai, V. M. Ghete, D. Hauff, F. Jeanneau, E. Jericha, M. Kaznacheeva, A. Kinast, H. Kluck, A. Langenkämper, T. Lasserre, D. Lhuillier, M. Mancuso, B. Mauri, A. Mazzolari, E. Mazzucato, H. Neyrial, C. Nones, L. Oberauer, T. Ortmann, L. Pattavina, L. Peters, F. Petricca, W. Potzel, F. Pröbst, F. Pucci, F. Riendl, R. Rogly, M. Romagnoni, J. Rothe, N. Schermer, J. Schieck, S. Schönert, C. Schwertner, L. Scola, G. Soum Sidikov, L. Stodolsky, R. Strauss, M. Tamisari, C. Tomei, M. Vignati, M. Vivier, V. Wagner, A. Wex (The NUCLEUS collaboration)

Subjects
Physics, QC1-999
Abstract

The NUCLEUS experiment aims to perform a high-precision measurement of Coherent Elastic Neutrino-Nucleus Scattering (CEvNS) at the EdF Chooz B nuclear power plant in France. CEvNS is a unique process to study neutrino properties and to search for physics beyond the Standard Model. The study of CEvNS is also important for light Dark-Matter searches. It could be a possible irreducible background for high-sensitivity Dark-Matter experiments. NUCLEUS is an experiment under construction based on ultra-low threshold ($\sim$20 eV$_{nr}$) cryogenic calorimeters, operated at tens-of-mK temperatures.

Published
2023
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81. Characterisation of low background CaWO$_4$ crystals for CRESST-III

Author

A. Kinast, G. Angloher, S. Banik, G. Benato, A. Bento, A. Bertolini, R. Breier, C. Bucci, J. Burkhart, L. Canonica, A. D'Addabbo, S. Di Lorenzo, L. Einfalt, A. Erb, F. v. Feilitzsch, N. Ferreiro Iachellini, S. Fichtinger, D. Fuchs, A. Fuss, A. Garai, V.M. Ghete, S. Gerster, P. Gorla, P.V. Guillaumon, S. Gupta, D. Hauff, M. Ješkovský, J. Jochum, M. Kaznacheeva, H. Kluck, H. Kraus, A. Langenkämper, M. Mancuso, L. Marini, L. Meyer, V. Mokina, A. Nilima, M. Olmi, T. Ortmann, C. Pagliarone, L. Pattavina, F. Petricca, W. Potzel, P. Povinec, F. Pröbst, F. Pucci, F. Reindl, J. Rothe, K. Schäffner, J. Schieck, D. Schmiedmayer, S. Schönert, C. Schwertner, M. Stahlberg, L. Stodolsky, C. Strandhagen, R. Strauss, I. Usherov, F. Wagner, M. Willers, V. Zema (CRESST Collaboration)

Subjects
Physics, QC1-999
Abstract

The CRESST-III experiment aims at the direct detection of dark matter particles via their elastic scattering off nuclei in a scintillating CaWO$_4$ target crystal. For many years CaWO$_4$ crystals have successfully been produced in-house at Technische Universität München with a focus on high radiopurity. To further improve the CaWO$_4$ crystals, an extensive chemical purification of the raw materials has been performed and the crystal TUM93 was produced from this powder. We present results from an $\alpha$-decay rate analysis performed on 344 days of data collected in the ongoing CRESST-III data-taking campaign. The $\alpha$-decay rate could significantly be reduced.

Published
2023
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82. NEOTROPICAL ALIEN MAMMALS : a data set of occurrence and abundance of alien mammals in the Neotropics

Author

da Rosa, Clarissa Alves, Ribeiro, Bruno R., Bejarano, Vanesa, Puertas, Fernando Henrique, Bocchiglieri, Adriana, dos Santos Barbosa, Adriana Loeser, Chiarello, Adriano Garcia, Paglia, Adriano Pereira, Pereira, Adriele Aparecida, de Souza Moreira, Adryelle Francisca, de Souza, Agnis Cristiane, Pellegrin, Aiesca, Gatica, Ailin, Medeiro, Akyllan Zoppi, Pereira, Alan Deivid, Braz, Alan Gerhardt, Yanosky, Alberto, Valenzuela, Alejandro Eduardo Jorge, Bertassoni, Alessandra, dos Santos Venturinido Prado, Alessandra, Nava, Alessandra Ferreira Dales, Rocha, Alessandro, Bovo, Alex Augusto Abreu, Bager, Alex, Cravino, Alexandra, dos Santos Pires, Alexandra, Martensen, Alexandre Camargo, Filippini, Alexandre, Percequillo, Alexandre Reis, Vogliotti, Alexandre, Antunes, Alexsander Zamorano, de Oliveira, Aline Cristina Leite, da Silva de Oliveira, Allan Jefferson, Devlin, Allison, de Paula, Almir, Ferreira, Aluane Silva, García-Olaechea, Alvaro, Subalusky, Amanda, Sánchez, Amadeo, de Aquino, Ana Carla Medeiros Morato, Srbek-Araujo, Ana Carolina, Gonçales, Amane Paldês, Araújo, Ana Caroline L., Gozzi, Ana Cecilia, Ochoa, Ana Cecilia, de Oliveira, Ana Cristina Mendes, Lacerda, Ana Cristyna Reis, Francisco, Ana Karina, de Oliveira Paschoal, Ana Maria, Gomes, Ana Paula Nascimento, Potrich, Ana Paula, Olímpio, Ana Priscila Medeiros, Rojas, Ana, Meiga, Ana Yoko Ykeuti, de Almeida Jácomo, Anah Tereza, Calaça, Analice Maria, Feijó, Anderson, Pagoto, Anderson, Miranda, André Borja, Alonso, André Chein, Barreto-Lima, André Felipe, Lanna, Andre, Luza, André Luís, Camilo, André Restel, Tavares, André, Nunes, André Valle, Kindel, Andreas, de Miguel, Andrés, Gatti, Andressa, Nobre, Andrezza Bellotto, da Conceição Campêlo, Anielise, de Albuquerque, Anna Carolina Figueiredo, de la Torre, Antonio, Mangione, Antonio, Pontes, Antonio Rossano Mendes, Fernandes, Arthur Soares, de Almeida Felicio, Artur Luiz, Ferreguetti, Atilla Colombo, Marcili, Arlei, Piratelli, Augusto João, do Nascimento, Ariel Guilherme Santos, dos Santos, Áureo Banhos, Rosa, Beatris Felipe, Cezila, Beatriz Azevedo, de Thoisy, Benoit, Ingberman, Bianca, Köhler, Bianca, Morais, Bianca Cruz, Gómez-Valencia, Bibiana, de Camargo, Bruna Bertagni, Bezerra, Bruna M., Tamasauskas, Bruna, Campos, Bruno A. T. Parahyba, Kubiak, Bruno Busnello, Saranholi, Bruno Henrique, Nakagawa, Bruno K., Leles, Bruno Pereira, Lim, Burton K., Mendes, Calebe Pereira, Islas, Camila Alvez, Aoki, Camila, Devids, Camila Cantagallo, Figueiredo, Camila, de Abreu, Camila Matias Goes, Oliveira, Camila Raquel Silva, Cassano, Camila Righetto, Lugarini, Camile, Caputo, Carin, Gestich, Carla Cristina, Tedesco, Carla Denise, de Vera y Conde, Carla Fabiane, Hegel, Carla Grasiele Zanin, Kasper, Carlos Benhur, De Angelo, Carlos, Grelle, Carlos E. V., Fragoso, Carlos Eduardo, Esbérard, Carlos Eduardo Lustosa, Rocha, Carlos Frederico Duarte, Verona, Carlos Eduardo, Salvador, Carlos Henrique, Vieira, Carlos Leonardo, Abrahão, Carlos Roberto, Brocardo, Carlos Rodrigo, Fieker, Carolline Zatta, Braga, Caryne, Lalinde, Catalina Sánchez, Bueno, Cecília, Ikuta, Cássia Yumi, Luna, Cecília Licarião Barreto, Cestari, Cesar, Del Vechio Koike, Christine, Knogge, Christoph, Anderson, Christopher Brian, Hurtado, Cindy M., de Oliveira, Cintia Ferreira Antunes, Tellaeche, Cintia, Cesário, Clarice Silva, Costa, Claudia Guimarães, Kanda, Claudia Zukeran, Costa, Sebastián Andrés, Seixas, Cristiana Simão, Trinca, Cristiano Trapé, López-Fuerte, Cristina F., da Cunha, Cristina Jaques, Ribas, Cynthia Doutel, Santos, Cyntia Cavalcante, Buscariol, Daiane, Carreira, Daiane, do Nascimento, Daiane Chaves, Carvalho, Danianderson Rodrigues, da Silva Ferraz, Daniel, Galiano, Daniel, Homem, Daniel Henrique, Jesús-Espinosa, Daniel, Bôlla, Daniela A. S., Moreno, Daniele Janina, de Oliveira Moreira, Danielle, Ramos, Danielle Leal, de Amorim, Danilo Angelucci, Barros-Battesti, Darci Moraes, Lopez, David Echeverri, Tavares, Davi Castro, Post, David M., Couto, Dayvid Rodrigues, Patrocínio, Dennis Nogarolli, Carvalho, Diana Letícia Kruger Pacheco, Silva, Diego Afonso, Córdoba, Diego, Queirolo, Diego, Varela, Diego, de Oliveira, Dilmar Alberto Goncalves, Casanova, Diogo Cavenague, de Matos Dias, Douglas, da Silva, Douglas Machado, Barbier, Eder, Rivadeneira, Edgar Federico, Alexandrino, Eduardo, Carrano, Eduardo, Santos, Eduardo Marques, Venticinque, Eduardo Martins, Hernández-Pérez, Edwin, da Fonseca Casazza, Egberto, Anderson, Elizabeth P., da Costa Fraga, Elmary, de Lima, Elson Fernandes, D’Bastiani, Elvira, Vieira, Emerson Monteiro, Guijosa-Guadarrama, Emiliano, González, Enrique M., Maggiorini, Erica Vanessa, de Aguiar, Erick Francisco Silva, Martínez-Nambo, Erik Daniel, Castro, Érika Paula, de la Peña-Cuéllar, Erika, Pedó, Ezequiel, de Melo, Fabiana Cristina S. Alves, Rocha, Fabiana Lopes, Fonseca, Fabiana Luques, Girardi, Fabiane, de Melo, Fabiano Rodrigues, de Oliveira Roque, Fábio, Ferreira, Fabíola Keesen, Peters, Felipe Bortolotto, Fantacini, Felipe Moreli, Pedrosa, Felipe, da Silva, Felipe Pessoa, Vélez-García, Felipe, Abra, Fernanda D., de Azevedo, Fernanda Cavalcanti, da Silva, Fernanda Guedes, Neri, Fernanda Maria, Teixeira, Fernanda Zimmermann, dos Santos Fernandez, Fernando Antonio, Carvalho, Fernando, Passos, Fernandode Camargo, de Castro Jacinavicius, Fernando, Ferreira, Fernando, de Pinho, Fernando Ferreira, Gonçalves, Fernando, Martins, Fernando Ibanez, Lima, Fernando, Contreras-Moreno, Fernando M., Ribeiro, Fernando Silvério, Tortato, Fernando, Patel, Filipe M., Caruso, Flavia, Tirelli, Flávia Pereira, Rodrigues, Flávio Henrique Guimarães, Ubaid, Flávio Kulaif, Palmeira, Francesca Belem Lopes, Neto, Francisco Grotta, Gabriel, Francisco Homem, de Souza, Franco Leandro, da Veiga da Costa, Francys E., de Aguiar, Gabriel Lima, Lemos, Frederico Gemesio, Magezi, Gabriel S., Di Panigai, Gabriel Ferreira Vianna, Hofmann, Gabriel Selbach, Heliodoro, Gabriela, Graviola, Gabriela Rosa, Beca, Gabrielle, de Andrade, Gabrielle Ribeiro, Romero, Germán Jiménez, Duarte, Gabriela Teixeira, Melo, Geruza Leal, Dierings, Geverson Luiz, Sabino-Santos, Gilberto, de Oliveira, Geovana Linhares, Santana, Gindomar Gomes, Ciocheti, Giordano, Zanirato, Gisele Lamberti, Alves, Giselle Bastos, Batista, Graziele Oliveira, Behling, Greici Maia, Ferreira, Guilherme Braga, da Rocha, Guilherme Casoni, Lessa, Gisele, Mourão, Guilherme, Maras, Gustavo A., da Costa Toledo, Gustavo Alves, Gonsioroski, Gustavo, Canale, Gustavo R., Schuchmann, Karl-Ludwig, Sebastião, Harley, do Prado, Helena Alves, de Godoy Bergallo, Helena, Secco, Helio Kinast Cruz, Roig, Henrique Llacer, Rajão, Henrique, Carlos, Henrique Santiago Alberto, de Oliveira B. Duarte, Herbert, Ermenegildo, Hiago, de Jesus Pena, Hilda Fátima, Júnior, Hilton Entringer, Neto, Hipólito Ferreira Paulino, de Macedo Lemos, Hudson, del Castillo, Hugo, Fernandes-Ferreira, Hugo, Banquero, Hugo Ignacio Coitiño, Roesler, Ignacio, Ribeiro, Igor Kintopp, Coelho, Igor Pfeifer, Lima, Ingrid M. S., Bechara, Isabel Muniz, Lermen, Isabel Salgueiro, Méndez, Isac Mella, Schuck, Gabriela, Esperandio, Isadora Beraldi, de Oliveria Silva, Ita, Mourthe, Italo, Oliveira, Igor, Bernardi, Itiberê Piaia, Miller, Jacqueline R., Marinho-Filho, Jader, Zocche, Jairo José, Russell, James Charles, Seibert, Jardel Brandão, Hinojosa, Javier, Vitule, Jean R. S., Thompson, Jeffrey J., Silva, Jean Carlos Ramos, Gouvea, Jéssica Abonízio, Santos, Jean Pierre, de Faria Falcão, Jéssica Caroline, Castro-Prieto, Jessica, Ferreira, Jéssica Paloma, Pincheira-Ulbrich, Jimmy, Nodari, Joana Zorzal, Gebin, João Carlos Zecchini, Giovanelli, João Gabriel Ribeiro, Miranda, João M. D., Souza-Alves, João Pedro, de Almeida Marins, João Rafael Gomes, Costa, Jociel Ferreira, Sponchiado, Jonas, de Souza, Jonathas Linds, Gallo, Jorge Alberto, Cherem, Jorge José, Cordeiro, José Luís Passos, Duarte, José Maurício Barbanti, Dantas, José Oliveira, de Matos, José Roberto, Pires, José Salatiel Rodrigues, Lanfranco, Juan Andrés Martínez, de la Cruz Godoy, Juan Camilo, Rudolf, Juan Carlos, Parrish, Juan Felipe Reátiga, Tellarini, Juan Francisco, Peña-Mondragón, Juan L., Arrabal, Juan Pablo, Reppucci, Juan, Ruiz-Esparza, Juan, Beduschi, Julia, de Faria Oshima, Júlia Emi, Ribeiro, Juliana Fernandes, de Almeida Rocha, Juliana Monteiro, Neto, José Soares Ferreira, dos Santos, Juliana Silveira, Pereira-Ribeiro, Juliane, Zanoni, Juliani Bruna, Bogoni, Juliano André, Ferreira, Juliana Rodrigues, Bicca-Marques, Júlio César, Pacheco, Julio Javier Chacón, de Oliveira Scarascia, Pietro, Guidoni-Martins, Karlo Gregório, Burs, Kathrin, de Barros Ferraz, Katia Maria Paschoaletto Micchi, Pisciotta, Kátia Regina, Von Kossel de Andrade Silva, Katyucha, Juarez, Keila MacFadem, de 1a Cruz-Félix, Keynes, de Morais, Kimberly Danielle Rodrigues, Candelária, Lana Pavão, Fornitano, Larissa, Bailey, Larissa Lynn, Gonçalves, Larissa Oliveira, Fasola, Laura, León, Laura Johanna Nova, de Andrade, Layla Reis, de Oliveira Marques, Leandro, Macedo, Leandro, Moreira, Leandro Santana, Silveira, Leandro, de Carvalho Oliveira, Leonardo, da Silva, Leonardo Henrique, Jerusalinsky, Leandro, La Serra, Leonardo, Costa, Leonardo Marques, Sartorello, Leonardo Rodrigues, Munhoes, Leticia Prado, Oliveira-Silva, Liany Regina B., de Pina, Ligia Ferracine, Bonjorne, Lilian, Rampim, Lilian Elaine, Sales, Lilian P., da Silva, Lucas Gonçalves, Quintilham, Lucas Lacerda Toth, Perillo, Lucas Neves, Rodríguez-Planes, Lucía Inés, Martín, Lucía, Araújo, Luciana Souza, Tiepolo, Liliani Marilia, Silva, Luciana Zago, Loaiza, Lina Marcela García, de Alagão Querido, Luciano Carramaschi, da Silva, Luciano Ferreira, La Sala, Luciano Francisco, Bopp, Luciano Tessare, Hufnagel, Ludmila, de Oliveira, Luiz Flamarion Barbosa, Oliveira-Santos, Luiz Gustavo Rodrigues, Lyra, Luiz Henrique, Guimarães, Luiza Neves, Segura, Luz Fernanda Jimenez, de Sousa, Luziene Conceição, Möcklinghoff, Lydia, Guichón, M. Laura, de la Maza, Javier, Barrios-Garcia, M. Noelia, Talamoni, Sônia A., Severo, Magnus Machado, Martins, Maísa Ziviani Alves, Oliveira, Marcela Alvares, Moraes, Marcela Figuerêdo Duarte, Lima, Marcela Guimarães Moreira, Pinheiro, Marcell Soares, do Carmo Pônzio, Marcella, Guerreiro, Marcello, Cervini, Marcelo, da Silva, Marcelo, Oliveira, Marcelo Juliano Rabelo, Magioli, Marcelo, Passamani, Marcelo, de Almeida, Marcelo Silva, Amaku, Marcos, de Oliveira, Márcio Leite, Tortato, Marcos Adriano, Melo, Marcos Antônio, Coutinho, Marcos E., Santos, Marcos Pérsio Dantas, Vieira, Marcus V., Andrade, Maria Augusta, Barros, Maria Claudene, do Rosario, Maria Cristina Ferreira, dos Santos Domit, Maria Dolores Alves, de Avelar Fernandes, Maria Emília, Iezzi, María Eugenia, do Nascimento, Maria Histele Sousa, Andrade-Núñez, María José, Lorini, Maria Lucia, de Castro Morini, Maria Santina, Nagy-Reis, Mariana B., Landis, Mariana Bueno, Vale, Mariana Moncassim, Xavier, Mariana Sampaio, Kaizer, Mariane C., Baptiste, Maria Piedad, Bergel, Mariano Maudet, Borgnia, Mariela, Barros, Marília A. S., da Silva, Marina Lima, Favarini, Marina Ochoa, Munerato, Marina Sales, Zaluar, Marina Trancoso, Winter, Marina, da Silva, Marina Xavier, Zanin, Marina, Marques, Marinêz Isaac, Haberfeld, Mario Burke, Di Bitetti, Mario S., Galliez, Maron, Alvarez, Martin R., Malerba, Martina, Rivero, Marina, Dias, Mateus Melo, de Oliveira, Mateus Yan, dos Reis, Matheus Gonçalves, Corrêa, Matheus Rocha Jorge, Graipel, Maurício Eduardo, Godoi, Mauricio N., Núñez-Regueiro, Maurício M., Moura, Mauricio Osvaldo, Orsi, Mário Luís, da Silva, Marco Aurélio Galvão, Lopez, Mauro Sanvicente, Benedetti, Maximiliano Augusto, Beltrão, Mayara Guimarães, Camino, Micaela, Faria, Michel Barros, Miretzki, Michel, Luiz, Micheli Ribeiro, Perine, Michell, Monteiro, Miguel Coutinho Moretta, Alves-Eigenheer, Milene, Perilli, Miriam Lucia Lages, da Silva, Mônica Andrade, Marini, Miguel Ângelo, Pereira, Monicque Silva, de Freitas Junior, Mozart Caetano, Cossa, Natalia, Denkiewicz, Natalia Mariana, Tôrres, Natália Mundim, Olifiers, Natalie, de Albuquerque, Natasha Moraes, Canassa, Nathália Fernandes, Detogne, Nathália, Filho, Newton Gurgel, Seoane, Nicolás Fernando, da Rosa Oliveira, Nicole, Megale, Nicoli, Pasqualotto, Nielson, Cáceres, Nilton Carlos, Peroni, Nivaldo, Zanella, Noeli, Pays, Olivier, Arimoro, Omolabake Alhambra Silva, Acevedo-Charry, Orlando, de Almeida Curi, Nelson Henrique, Pinha, Patricia Ribeiro Salgado, Perovic, Pablo, Gonçalves, Pablo Rodrigues, Santos, Paloma Marques, de Goés Brennand, Pamella Gusmão, Rogeri, Patrícia Kerches, Ribeiro, Patrícia Rosas, da Rocha, Patrício Adriano, de Lázari, Patrick Ricardo, Pedreira, Paula Anabel, Pinheiro, Paula Fabiana, Lira, Paula Koeler, Ferreira, Paula Modenesi, Martin, Paula Sanches, de Tarso Zuquim Antas, Paulo, Marinho, Paulo Henrique, Ruffino, Paulo Henrique Peira, Camargo, Paulo Henrique S. A., Filho, Paulo Landgref, Mangini, Paulo Rogério, Farias, Patrick, Cordeiro-Estrela, Pedro, de Faria Peres, Pedro Henrique, Galetti, Pedro Manoel, Ramírez-Bautista, Pedro, de Almeida Maués, Paula Cristina Rodrigues, Renaud, Pierre-Cyril, Sartorello, Ricardo, de Barros, Pollyanna Alves, Lombardi, Pryscilla Moura, Bessa, Rafael, Arroyo-Gerala, Paulina, de Souza, Rafael Cerqueira Castro, Zenni, Rafael D., Peredo, Rafael Flores, Hoogesteijn, Rafael, Loyola, Rafael, Alves, Rafael Souza Cruz, de Paula Rodarte, Raisa Reis, Silva, Ramon Lima, de Oliveira, Ramonna, Beltrão-Mendes, Raone, de Macêdo Alencar, Raony, da Silva, Raquel Costa, Pedroso, Rayssa, Sampaio, Rebeca Ferreira, Ribeiro, Renan Lieto Alves, Pardini, Renata, Bonikowski, Renata Twardowsky Ramalho, Pagotto, Renata Valls, Dias, Ricardo Augusto, Bassini-Silva, Ricardo, Arrais, Ricardo Corassa, Sampaio, Ricardo, de Cassia Bianchi, Rita, Paolino, Roberta Montanheiro, Fusco-Costa, Roberto, Trovati, Roberto Guilherme, Hack, Robson Odeli Espíndola, de Arruda Mauro, Rodiney, de Almeida Nobre, Rodrigo, Gessulli, Rodrigo Delmonte, Pérez, Rodrigo León, Massara, Rodrigo Lima, da Silva, Rodrigo Medina Fróes, de Paula, Rogério Cunha, da Cunha, Rogério Grassetto Teixeira, Costa, Rômulo Theodoro, Marques, Rosane Vera, Morato, Ronaldo Gonçalves, Bovendorp, Ricardo S., da Paixão Dornas, Rubem Augusto, Andrade, Rubia Santana, Siciliano, Salvatore, Guaragni, Samara Arsego, Rolim, Samir Gonçalves, Astete, Samuel, Cavalcanti, Sandra, Hartz, Sandra Maria, Carvalho, Santiago, Cortez, Sara, de Sousa, Saulo Meneses Silvestre, Ballari, Sebastián A., Lima, Saulo Ramos, Cirignoli, Sebastián, García-R, Sebastian, Bazilio, Sérgio, Torres, Sergio Solari, Franco, Silvana Back, Martins, Simone Rebouças, de Bustos, Soledad, Age, Stefani Gabrieli, Ferrari, Stephen Francis, Francisco, Talitha Mayumi, Micheletti, Tatiane, da Silva Godim, Tayanna Medonça, Luiz, Thais Guimaraes, de Freitas, Thales Renato Ochotorena, Rodrigues, Thiago Ferreira, Piovezan, Ubiratan, Barcos, Umberto Cotrim, Onofrio, Valeria Castilho, Martin-Albarracin, Valeria L., Towns, Valeria, Araújo, Valquíria Cabral, Kanaan, Vanessa, Daga, Vanessa Salete, Boere, Vanner, de Araujo, Verônica Parente Gomes, Benitez, Verónica Victoria, Leandro-Silva, Victor, Geraldi, Vilma Clarice, Alberici, Vinicius, Bastazini, Vinícius Augusto Galvão, de Oliveira Gasparotto, Vinícius Peron, Orsini, Vinícius Santana, da Silva, Virgínia Santiago, Bonzi, Viviana Rojas, Pereira, Vinicius José Alves, Layme, Viviane Maria Guedes, da Silva, Victor Hugo Duarte, Tomas, Walfrido Moraes, De Almeida Moreira, Thamy, Martins, Waldney Pereira, de Moraes Pires, Walna Micaelle, Hannibal, Wellington, Dáttilo, Wesley, Mottin, Viviane, Endo, Whaldener, Bercê, William, Carvalho, William Douglas, Magnusson, William, Akkawi, Paula, Di Blanco, Yamil, Amaral, Paulo Roberto, Ramos, Yan Gabriel Celli, Rodríguez-Calderón, Yenifer G., Mendes, Yuri Raia, Ribeiro, Yuri Geraldo Gomes, Campos, Zilca, Galetti, Mauro, and Ribeiro, Milton Cezar

Published
2020

84. Optic nerve cavitations in glaucoma suspect and glaucoma patients

Author

Bennett Y. Hong, Brad Fortune, Robert M. Kinast, Claude F. Burgoyne, Jack P. Rees, and Steven L. Mansberger

Subjects
Optic nerve cavitations, Intrachoroidal cavitations, Lamina cribosa, Glaucoma, Imaging, Optical coherence tomography, Ophthalmology, RE1-994
Abstract

Purpose: Glaucoma is associated with structural changes of the optic nerve head such as deformation, lamina cribosa defects, prelaminar schisis, and peripapillary retinal schisis. We describe optic nerve cavitations that were detected by routine spectral domain optical coherence tomography (OCT). Observations: OCT imaging showed cavitations in 5 eyes of 4 patients with an initial diagnosis of glaucoma or glaucoma suspect. The cavitations were seen as hyporeflective spaces that are sharply delineated from surrounding tissue. They were centered inferonasally, anterior to the lamina cribosa, and at least partially within the Bruch's membrane opening (BMO). They extended from 3 to 6 clock hours. Conclusion: AND IMPORTANCE: We describe a new OCT finding in patients with a diagnosis of glaucoma and glaucoma suspect. While previous reports describe cavitations in the choroid in patients with pathological myopia, our patients had minimal refractive error and the cavitations were located within the optic nerve. We will examine these patients over time to determine the impact of this finding on longitudinal changes in structure and function.

Published
2022
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88. A Genome-Wide Arrayed CRISPR Screen Reveals PLSCR1 as an Intrinsic Barrier to SARS-CoV-2 Entry

Author

Le Pen, Jeremie, primary, Paniccia, Gabrielle, additional, Bauer, Michael, additional, Hoffmann, H.-Heinrich, additional, Kinast, Volker, additional, Moncada-Velez, Marcela, additional, Pinharanda, Ana, additional, Ricardo-Lax, Inna, additional, Stenzel, Ansgar F, additional, Rosado-Olivieri, Edwin A, additional, Ashbrook, Alison W, additional, Dinnon, Kenneth H, additional, Doyle, William, additional, Freije, Catherine, additional, Hong, Seon-Hui, additional, Lee, Danyel, additional, Lewy, Tyler, additional, Luna, Joseph M, additional, Peace, Avery, additional, Schmidt, Carltin, additional, Schneider, Willia M, additional, Winkler, Roni, additional, Larson, Chloe, additional, McGinn, Timothy, additional, Menezes, Miriam-Rose, additional, Ramos-Espiritu, Lavoisier, additional, Banerjee, Priyam, additional, Poirier, John T, additional, Sanchez-Rivera, Francisco J, additional, Zhang, Qian, additional, Casanova, Jean-Laurent, additional, Carroll, Thomas S, additional, Glickman, J. Fraser, additional, Michailidis, Eleftherios, additional, Razooky, Brandon, additional, MacDonald, Margaret R, additional, and Rice, Charles M, additional

Published
2024
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89. Geant4 simulations of the influence of contamination and roughness of the detector surface on background spectra in CRESST

Author

Grüner, Christoph, primary, Angloher, G., additional, Banik, S., additional, Benato, G., additional, Bento, A., additional, Bertolini, A., additional, Breier, R., additional, Bucci, C., additional, Burkhart, J., additional, Canonica, L., additional, D'Addabbo, A., additional, Di Lorenzo, S., additional, Einfalt, L., additional, Erb, A., additional, v. Feilitzsch, F., additional, Fichtinger, S., additional, Fuchs, D., additional, Garai, A., additional, Ghete, V.M., additional, Gorla, P., additional, Guillaumon, P.V., additional, Gupta, S. K., additional, Hauff, D., additional, Ješkovský, M., additional, Jochum, J., additional, Kaznacheeva, M., additional, Kinast, A., additional, Kluck, H., additional, Kraus, H., additional, Kuckuk, S., additional, Langenkämper, A., additional, Mancuso, M., additional, Marini, L., additional, Mauri, B., additional, Meyer, L., additional, Mokina, Valentyna, additional, Olmi, M., additional, Ortmann, T., additional, Pagliarone, C. E., additional, Pattavina, L., additional, Petricca, F., additional, Potzel, W., additional, Povinec, P., additional, Pröbst, F., additional, Pucci, F., additional, Reindl, F., additional, Rothe, J., additional, Schäffner, K., additional, Schieck, J., additional, Schönert, S., additional, Schwertner, C., additional, Stahlberg, M., additional, Stodolsky, L., additional, Strandhagen, C., additional, Strauss, R., additional, Usherov, I., additional, Wagner, F., additional, Willers, M., additional, and Zema, V., additional

Published
2024
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96. Robust hepatitis E virus infection and transcriptional response in human hepatocytes

Author

Todt, Daniel, Friesland, Martina, Moeller, Nora, Praditya, Dimas, Kinast, Volker, Brüggemann, Yannick, Knegendorf, Leonard, Burkard, Thomas, Steinmann, Joerg, Burm, Rani, Verhoye, Lieven, Wahid, Avista, Meister, Toni Luise, Engelmann, Michael, Pfankuche, Vanessa M., Puff, Christina, Vondran, Florian W. R., Baumgärtner, Wolfgang, Meuleman, Philip, Behrendt, Patrick, and Steinmann, Eike

Published
2020

98. Normalization of blood clotting characteristics using prothrombin complex concentrate, fibrinogen and FXIII in an albumin based fluid: experimental studies in thromboelastometry

Author

Tobias Koller, Nadia Kinast, Andres Guilarte Castellanos, Sergio Perez Garcia, Pilar Paniagua Iglesias, Xavi León Vintro, Jose Mateo Arranz, Noelia Vilalta Seto, Ma. Victòria Moral García, Ana Belén Moreno-Castaño, Jose Aznar-Salatti, Gines Escolar Albaladejo, and Maribel Diaz-Ricart

Subjects
Massive bleeding, Blood transfusion, Fibrinogen, Factor XIII, Prothrombin complex concentrate, Fluid therapy, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Colloid fluids supplemented with adequate combinations of coagulation factor concentrates with the capability to restore coagulation could be a desirable future treatment component in massive transfusion. Methods Starting from a coagulation factor and blood cell-free albumin solution we added Prothrombin Complex Concentrate, Fibrinogen Concentrate and Factor XIII in different combinations and concentrations to analyze their properties to restore thromboelastometry parameters without the use of plasma. Further analysis under the presence of platelets was performed for comparability to whole blood conditions. Results Albumin solutions enriched with Fibrinogen Concentrate, Factor XIII and Prothrombin Complex Concentrate at optimized concentrations show restoring coagulation potential. Prothrombin Complex Concentrate showed sufficient thrombin formation for inducing fibrinogen polymerization. The combination of Prothrombin Complex Concentrate and Fibrinogen Concentrate led to the formation of a stable in vitro fibrin clot. Fibrinogen and Factor XIII showed excellent capacity to improve fibrin clot firmness expressed as Amplitude at 10 min and Maximal Clot Firmness. Fibrinogen alone, or in combination with Factor XIII, was able to restore normal Amplitude at 10 min and Maximal Clot Firmness values. In the presence of platelets, the thromboelastometry surrogate parameter for thrombin generation (Clotting Time) improves and normalizes when compared to whole blood. Conclusions Combinations of coagulation factor concentrates suspended in albumin solutions can restore thromboelastometry parameters in the absence of plasma. This kind of artificial colloid fluids with coagulation-restoring characteristics might offer new treatment alternatives for massive transfusion. Trial registration Study registered at the institutional ethic committee “Institut de Recerca, Hospital Santa Creu i Sant Pau, with protocol number IIBSP-CFC-2013-165.

Published
2021
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