1,378 results on '"Kimmel, Paul"'
Search Results
52. Risk of ESRD and Mortality Associated With Change in Filtration Markers
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Rebholz, Casey M, Inker, Lesley A, Chen, Yuan, Liang, Menglu, Foster, Meredith C, Eckfeldt, John H, Kimmel, Paul L, Vasan, Ramachandran S, Feldman, Harold I, Sarnak, Mark J, Hsu, Chi-yuan, Levey, Andrew S, Coresh, Josef, and Consortium, Chronic Kidney Disease Biomarkers
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Biomedical and Clinical Sciences ,Clinical Sciences ,Kidney Disease ,Clinical Research ,Prevention ,Nutrition ,Renal and urogenital ,Good Health and Well Being ,Biomarkers ,Clinical Trials as Topic ,Female ,Glomerular Filtration Rate ,Humans ,Kidney Failure ,Chronic ,Male ,Middle Aged ,Prospective Studies ,Risk Assessment ,Beta-2-microglobulin ,beta trace protein ,creatinine ,cystatin C ,filtration markers ,death ,mortality ,end-stage renal disease ,incident ESRD ,glomerular filtration rate ,estimated GFR ,measured GFR ,kidney function decline ,Chronic Kidney Disease Biomarkers Consortium ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundUsing change in estimated glomerular filtration rate (eGFR) based on creatinine concentration as a surrogate outcome in clinical trials of chronic kidney disease has been proposed. Risk for end-stage renal disease (ESRD) and all-cause mortality associated with change in concentrations of other filtration markers has not been studied in chronic kidney disease populations.Study designObservational analysis of 2 clinical trials.Setting & participantsParticipants in the MDRD (Modification of Diet in Renal Disease; n=317) Study and AASK (African American Study of Kidney Disease and Hypertension; n=373).PredictorsCreatinine, cystatin C, β-trace protein (BTP), and β2-microglobulin (B2M) were measured in serum samples collected at the 12- and 24-month follow-up visits, along with measured GFR (mGFR) at these time points.OutcomesESRD and all-cause mortality.MeasurementsPoisson regression was used to estimate incidence rate ratios and 95% CIs for ESRD and all-cause mortality during long-term follow-up (10-16 years) per 30% decline in mGFR or eGFR for each filtration marker and the average of all 4 markers.Results1-year decline in mGFR, eGFRcr, eGFRBTP, and the average of the 4 filtration markers was significantly associated with increased risk for incident ESRD in both studies (all P≤0.02). Compared to mGFR, only decline in eGFRBTP was statistically significantly more strongly associated with ESRD risk in both studies (both P≤0.03). Decline in eGFRcr, but not mGFR or the other filtration markers, was significantly associated with risk for all-cause mortality in AASK only (incidence rate ratio per 30% decline, 4.17; 95% CI, 1.78-9.74; P
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- 2017
53. Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression.
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Hsu, Chi-Yuan, Xie, Dawei, Waikar, Sushrut S, Bonventre, Joseph V, Zhang, Xiaoming, Sabbisetti, Venkata, Mifflin, Theodore E, Coresh, Josef, Diamantidis, Clarissa J, He, Jiang, Lora, Claudia M, Miller, Edgar R, Nelson, Robert G, Ojo, Akinlolu O, Rahman, Mahboob, Schelling, Jeffrey R, Wilson, Francis P, Kimmel, Paul L, Feldman, Harold I, Vasan, Ramachandran S, Liu, Kathleen D, CRIC Study Investigators, and CKD Biomarkers Consortium
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CRIC Study Investigators ,CKD Biomarkers Consortium ,Kidney Tubules ,Humans ,Kidney Failure ,Chronic ,Albuminuria ,Disease Progression ,Creatinine ,Acetylglucosaminidase ,Glomerular Filtration Rate ,Proportional Hazards Models ,Risk Assessment ,Risk Factors ,Follow-Up Studies ,Prospective Studies ,Aged ,Middle Aged ,Female ,Male ,Fatty Acid-Binding Proteins ,Renal Insufficiency ,Chronic ,Biomarkers ,Lipocalin-2 ,Hepatitis A Virus Cellular Receptor 1 ,chronic kidney disease ,microalbuminuria ,proteinuria ,Kidney Disease ,Patient Safety ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Renal and urogenital ,Good Health and Well Being ,Clinical Sciences ,Urology & Nephrology - Abstract
Few investigations have evaluated the incremental usefulness of tubular injury biomarkers for improved prediction of chronic kidney disease (CKD) progression. As such, we measured urinary kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, N-acetyl-ß-D-glucosaminidase and liver fatty acid binding protein under highly standardized conditions among 2466 enrollees of the prospective Chronic Renal Insufficiency Cohort Study. During 9433 person-years of follow-up, there were 581 cases of CKD progression defined as incident end-stage renal disease or halving of the estimated glomerular filtration rate. Levels of the urine injury biomarkers, normalized for urine creatinine, were strongly associated with CKD progression in unadjusted Cox proportional hazard models with hazard ratios in the range of 7 to 15 comparing the highest with the lowest quintiles. However, after controlling for the serum creatinine-based estimated glomerular filtration rate and urinary albumin/creatinine ratio, none of the normalized biomarkers was independently associated with CKD progression. None of the biomarkers improved on the high (0.89) C-statistic for the base clinical model. Thus, among patients with CKD, risk prediction with a clinical model that includes the serum creatinine-based estimated glomerular filtration rate and the urinary albumin/creatinine ratio is not improved on with the addition of renal tubular injury biomarkers.
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- 2017
54. Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND)
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Williams, Robert C, Elston, Robert C, Kumar, Pankaj, Knowler, William C, Abboud, Hanna E, Adler, Sharon, Bowden, Donald W, Divers, Jasmin, Freedman, Barry I, Igo, Robert P, Ipp, Eli, Iyengar, Sudha K, Kimmel, Paul L, Klag, Michael J, Kohn, Orly, Langefeld, Carl D, Leehey, David J, Nelson, Robert G, Nicholas, Susanne B, Pahl, Madeleine V, Parekh, Rulan S, Rotter, Jerome I, Schelling, Jeffrey R, Sedor, John R, Shah, Vallabh O, Smith, Michael W, Taylor, Kent D, Thameem, Farook, Thornley-Brown, Denyse, Winkler, Cheryl A, Guo, Xiuqing, Zager, Phillip, Hanson, Robert L, and the FIND Research Group
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Biological Sciences ,Genetics ,American Indian or Alaska Native ,Diabetes ,Health Disparities ,Minority Health ,Human Genome ,Metabolic and endocrine ,Black or African American ,Algorithms ,Chromosome Mapping ,Diabetic Nephropathies ,Genetic Markers ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Indians ,North American ,Likelihood Functions ,Mexican Americans ,Models ,Genetic ,Oligonucleotide Array Sequence Analysis ,Polymorphism ,Single Nucleotide ,Principal Component Analysis ,United States ,White People ,Individual genetic ancestry ,Population structure ,SNP ,Diabetic nephropathy ,FIND Research Group ,Information and Computing Sciences ,Medical and Health Sciences ,Bioinformatics ,Biological sciences ,Biomedical and clinical sciences - Abstract
BackgroundThe presence of population structure in a sample may confound the search for important genetic loci associated with disease. Our four samples in the Family Investigation of Nephropathy and Diabetes (FIND), European Americans, Mexican Americans, African Americans, and American Indians are part of a genome- wide association study in which population structure might be particularly important. We therefore decided to study in detail one component of this, individual genetic ancestry (IGA). From SNPs present on the Affymetrix 6.0 Human SNP array, we identified 3 sets of ancestry informative markers (AIMs), each maximized for the information in one the three contrasts among ancestral populations: Europeans (HAPMAP, CEU), Africans (HAPMAP, YRI and LWK), and Native Americans (full heritage Pima Indians). We estimate IGA and present an algorithm for their standard errors, compare IGA to principal components, emphasize the importance of balancing information in the ancestry informative markers (AIMs), and test the association of IGA with diabetic nephropathy in the combined sample.ResultsA fixed parental allele maximum likelihood algorithm was applied to the FIND to estimate IGA in four samples: 869 American Indians; 1385 African Americans; 1451 Mexican Americans; and 826 European Americans. When the information in the AIMs is unbalanced, the estimates are incorrect with large error. Individual genetic admixture is highly correlated with principle components for capturing population structure. It takes ~700 SNPs to reduce the average standard error of individual admixture below 0.01. When the samples are combined, the resulting population structure creates associations between IGA and diabetic nephropathy.ConclusionsThe identified set of AIMs, which include American Indian parental allele frequencies, may be particularly useful for estimating genetic admixture in populations from the Americas. Failure to balance information in maximum likelihood, poly-ancestry models creates biased estimates of individual admixture with large error. This also occurs when estimating IGA using the Bayesian clustering method as implemented in the program STRUCTURE. Odds ratios for the associations of IGA with disease are consistent with what is known about the incidence and prevalence of diabetic nephropathy in these populations.
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- 2016
55. Nonpharmacologic Treatments for Opioid Reduction in Patients With Advanced Chronic Kidney Disease
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Brintz, Carrie E., Cheatle, Martin D., Dember, Laura M., Heapy, Alicia A., Jhamb, Manisha, Shallcross, Amanda J., Steel, Jennifer L., Kimmel, Paul L., and Cukor, Daniel
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- 2021
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56. Effects of intensive versus standard blood pressure control on domain-specific cognitive function: a substudy of the SPRINT randomised controlled trial
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Rapp, Stephen R, Pajewski, Nicholas M, Auchus, Alexander P, Chelune, Gordon, Cheung, Alfred K, Cleveland, Maryjo L, Coker, Laura H, Crowe, Michael G, Cushman, William C, Cutler, Jeffery A, Davatzikos, Christos, Desiderio, Lisa, Doshi, Jimit, Erus, Guray, Fine, Lawrence J, Gaussoin, Sarah A, Harris, Darrin, Johnson, Karen C, Kimmel, Paul L, Tamura, Manjula K, Launer, Lenore J, Lerner, Alan J, Lewis, Cora E, Martindale-Adams, Jennifer, Moy, Claudia S, Nichols, Linda O, Oparil, Suzanne, Ogrocki, Paula K, Rahman, Mahboob, Nasrallah, Ilya M, Reboussin, David M, Rocco, Michael V, Sachs, Bonnie C, Sink, Kaycee M, Still, Carolyn H, Supiano, Mark A, Snyder, Joni K, Wadley, Virginia G, Walker, Jennifer, Weiner, Daniel E, Whelton, Paul K, Wilson, Valerie M, Woolard, Nancy, Wright, Jackson T, Jr., Wright, Clinton B, Williamson, Jeff D, Bryan, R Nick, Wilson, Valarie M, Whittle, Jeff C, Beddhu, Srinivasan, Berlowitz, Dan R, Bress, Adam P, Krousel-Wood, Marie, Miller, Eliza C, Rifkin, Dena E, Tamariz, Leonardo, Wolfgram, Dawn F, Yang, Mia, and Bryan, Robert Nick
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- 2020
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57. A prospective controlled study of metabolic and physiologic effects of kidney donation suggests that donors retain stable kidney function over the first nine years
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Kasiske, Bertram L., Anderson-Haag, Tracy L., Duprez, Daniel A., Kalil, Roberto S., Kimmel, Paul L., Pesavento, Todd E., Snyder, Jon J., and Weir, Matthew R.
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- 2020
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58. Metabolites Associated With Uremic Symptoms in Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
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Wulczyn, Kendra E., primary, Shafi, Tariq, additional, Anderson, Amanda, additional, Rincon-Choles, Hernan, additional, Clish, Clary B., additional, Denburg, Michelle, additional, Feldman, Harold I., additional, He, Jiang, additional, Hsu, Chi-yuan, additional, Kelly, Tanika, additional, Kimmel, Paul L., additional, Mehta, Rupal, additional, Nelson, Robert G., additional, Ramachandran, Vasan, additional, Ricardo, Ana, additional, Shah, Vallabh O., additional, Srivastava, Anand, additional, Xie, Dawei, additional, Rhee, Eugene P., additional, Kalim, Sahir, additional, Dember, Laura M., additional, Landis, J. Richard, additional, Townsend, Raymond R., additional, Appel, Lawrence, additional, Fink, Jeffrey, additional, Rahman, Mahboob, additional, Horwitz, Edward J., additional, Taliercio, Jonathan J., additional, Rao, Panduranga, additional, Sondheimer, James H., additional, Lash, James P., additional, Chen, Jing, additional, Go, Alan S., additional, Parsa, Afshin, additional, and Rankin, Tracy, additional
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- 2024
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59. Association of Obesity, Metabolic Syndrome, and Diabetes With Urinary Incontinence and Chronic Kidney Disease: Analysis of the National Health and Nutrition Examination Survey, 2003-2020
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Fwu, Chyng-Wen, primary, Schulman, Ivonne H., additional, Lawrence, Jean M., additional, Kimmel, Paul L., additional, Eggers, Paul, additional, Norton, Jenna, additional, Chan, Kevin, additional, Mendley, Susan R., additional, and Barthold, Julia S., additional
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- 2024
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60. Abnormalities in biomarkers of mineral and bone metabolism in kidney donors
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Kasiske, Bertram L, Kumar, Rajiv, Kimmel, Paul L, Pesavento, Todd E, Kalil, Roberto S, Kraus, Edward S, Rabb, Hamid, Posselt, Andrew M, Anderson-Haag, Teresa L, Steffes, Michael W, Israni, Ajay K, Snyder, Jon J, Singh, Ravinder J, and Weir, Matthew R
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Biomedical and Clinical Sciences ,Clinical Sciences ,Kidney Disease ,Osteoporosis ,Clinical Research ,2.1 Biological and endogenous factors ,Aetiology ,Renal and urogenital ,Musculoskeletal ,Adult ,Alkaline Phosphatase ,Biomarkers ,Bone Resorption ,Bone and Bones ,Calcitriol ,Collagen Type I ,Female ,Fibroblast Growth Factor-23 ,Fibroblast Growth Factors ,Humans ,Kidney Transplantation ,Living Donors ,Male ,Middle Aged ,Minerals ,Nephrectomy ,Osteocalcin ,Parathyroid Hormone ,Peptide Fragments ,Peptides ,Phosphates ,Procollagen ,Prospective Studies ,Renal Reabsorption ,Vitamin D ,FGF23 ,hyperparathyroidism ,mineral metabolism ,parathyroid hormone ,Urology & Nephrology ,Clinical sciences - Abstract
Previous studies have suggested that kidney donors may have abnormalities of mineral and bone metabolism typically seen in chronic kidney disease. This may have important implications for the skeletal health of living kidney donors and for our understanding of the pathogenesis of long-term mineral and bone disorders in chronic kidney disease. In this prospective study, 182 of 203 kidney donors and 173 of 201 paired normal controls had markers of mineral and bone metabolism measured before and at 6 and 36 months after donation (ALTOLD Study). Donors had significantly higher serum concentrations of intact parathyroid hormone (24.6% and 19.5%) and fibroblast growth factor-23 (9.5% and 8.4%) at 6 and 36 months, respectively, as compared to healthy controls, and significantly reduced tubular phosphate reabsorption (-7.0% and -5.0%) and serum phosphate concentrations (-6.4% and -2.3%). Serum 1,25-dihydroxyvitamin D3 concentrations were significantly lower (-17.1% and -12.6%), while 25-hydroxyvitamin D (21.4% and 19.4%) concentrations were significantly higher in donors compared to controls. Moreover, significantly higher concentrations of the bone resorption markers, carboxyterminal cross-linking telopeptide of bone collagen (30.1% and 13.8%) and aminoterminal cross-linking telopeptide of bone collagen (14.2% and 13.0%), and the bone formation markers, osteocalcin (26.3% and 2.7%) and procollagen type I N-terminal propeptide (24.3% and 8.9%), were observed in donors. Thus, kidney donation alters serum markers of bone metabolism that could reflect impaired bone health. Additional long-term studies that include assessment of skeletal architecture and integrity are warranted in kidney donors.
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- 2016
61. Relationship of proximal tubular injury to chronic kidney disease as assessed by urinary kidney injury molecule-1 in five cohort studies.
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Waikar, Sushrut S, Sabbisetti, Venkata, Ärnlöv, Johan, Carlsson, Axel C, Coresh, Josef, Feldman, Harold I, Foster, Meredith C, Fufaa, Gudeta D, Helmersson-Karlqvist, Johanna, Hsu, Chi-Yuan, Kimmel, Paul L, Larsson, Anders, Liu, Yumin, Lind, Lars, Liu, Kathleen D, Mifflin, Theodore E, Nelson, Robert G, Risérus, Ulf, Vasan, Ramachandran S, Xie, Dawei, Zhang, Xiaoming, Bonventre, Joseph V, and Chronic Kidney Disease Biomarkers Consortium Investigators
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Chronic Kidney Disease Biomarkers Consortium Investigators ,Kidney Tubules ,Proximal ,Humans ,Albuminuria ,Risk Factors ,Prospective Studies ,Adult ,Aged ,Middle Aged ,Sweden ,Female ,Male ,Renal Insufficiency ,Chronic ,Young Adult ,Biomarkers ,Hepatitis A Virus Cellular Receptor 1 ,KIM-1 ,albuminuria ,chronic kidney disease ,Kidney Disease ,Physical Injury - Accidents and Adverse Effects ,Clinical Research ,Renal and urogenital ,Good Health and Well Being ,Clinical Sciences ,Urology & Nephrology - Abstract
BackgroundThe primary biomarkers used to define CKD are serum creatinine and albuminuria. These biomarkers have directed focus on the filtration and barrier functions of the kidney glomerulus even though albuminuria results from tubule dysfunction as well. Given that proximal tubules make up ∼90% of kidney cortical mass, we evaluated whether a sensitive and specific marker of proximal tubule injury, urinary kidney injury molecule-1 (KIM-1), is elevated in individuals with CKD or with risk factors for CKD.MethodsWe measured urinary KIM-1 in participants of five cohort studies from the USA and Sweden. Participants had a wide range of kidney function and were racially and ethnically diverse. Multivariable linear regression models were used to test the association of urinary KIM-1 with demographic, clinical and laboratory values.ResultsIn pooled, multivariable-adjusted analyses, log-transformed, creatinine-normalized urinary KIM-1 levels were higher in those with lower eGFR {β = -0.03 per 10 mL/min/1.73 m(2) [95% confidence interval (CI) -0.05 to -0.02]} and greater albuminuria [β = 0.16 per unit of log albumin:creatinine ratio (95% CI 0.15-0.17)]. Urinary KIM-1 levels were higher in current smokers, lower in blacks than nonblacks and lower in users versus nonusers of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers.ConclusionProximal tubule injury appears to be an integral and measurable element of multiple stages of CKD.
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- 2016
62. Serum β-Trace Protein and β2-Microglobulin as Predictors of ESRD, Mortality, and Cardiovascular Disease in Adults With CKD in the Chronic Renal Insufficiency Cohort (CRIC) Study
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Foster, Meredith C, Coresh, Josef, Hsu, Chi-yuan, Xie, Dawei, Levey, Andrew S, Nelson, Robert G, Eckfeldt, John H, Vasan, Ramachandran S, Kimmel, Paul L, Schelling, Jeffrey, Simonson, Michael, Sondheimer, James H, Anderson, Amanda Hyre, Akkina, Sanjeev, Feldman, Harold I, Kusek, John W, Ojo, Akinlolu O, Inker, Lesley A, Investigators, CKD Biomarker Consortium and the CRIC Study, Appel, Lawrence J, Go, Alan S, He, Jiang, Lash, James P, Rahman, Mahboob, and Townsend, Raymond R
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Biomedical and Clinical Sciences ,Clinical Sciences ,Prevention ,Clinical Research ,Kidney Disease ,Cardiovascular ,Renal and urogenital ,Good Health and Well Being ,Biomarkers ,Cardiovascular Diseases ,Cohort Studies ,Female ,Humans ,Intramolecular Oxidoreductases ,Kidney Failure ,Chronic ,Lipocalins ,Male ,Middle Aged ,Predictive Value of Tests ,Prospective Studies ,Renal Insufficiency ,Chronic ,beta 2-Microglobulin ,Beta-trace protein ,beta(2)-microglobulin ,CKD Biomarkers Consortium ,filtration markers ,renal function ,estimated glomerular filtration rate ,chronic kidney disease ,end-stage renal disease ,mortality ,cardiovascular events ,Chronic Renal Insufficiency Cohort ,CKD Biomarker Consortium and the CRIC Study Investigators ,β(2)-microglobulin ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundSerum β-trace protein (BTP) and β2-microglobulin (B2M) are independently associated with end-stage renal disease (ESRD) and mortality in the general population and high-risk groups with diabetes or advanced chronic kidney disease (CKD). Less is known about their associations with outcomes and predictive ability in adults with moderate CKD.Study designProspective cohort study.Setting & participants3,613 adults from the CRIC (Chronic Renal Insufficiency Cohort) Study (45% women; mean age, 57.9 years; 41.0% non-Hispanic black; 51.9% with diabetes).PredictorsBTP and B2M levels with a reciprocal transformation to reflect their associations with filtration, creatinine-based estimated glomerular filtration rate (eGFRcr), measured GFR, and a 4-marker composite score combining BTP, B2M, creatinine, and cystatin C levels. Predictors were standardized as z scores for comparisons across filtration markers.OutcomesESRD, all-cause mortality, and new-onset cardiovascular disease.ResultsDuring a 6-year median follow-up, 755 (21%) participants developed ESRD, 653 died, and 292 developed new-onset cardiovascular disease. BTP, B2M, and the 4-marker composite score were independent predictors of ESRD and all-cause mortality, and B2M and the 4-marker composite score of cardiovascular events, after multivariable adjustment. These associations were stronger than those observed for eGFRcr (P vs eGFRcr≤0.02). The 4-marker composite score led to improvements in C statistic and 2.5-year risk reclassification beyond eGFRcr for all outcomes.LimitationsFiltration markers measured at one time point; measured GFR available in subset of cohort.ConclusionsBTP and B2M levels may contribute additional risk information beyond eGFRcr, and the use of multiple markers may improve risk prediction beyond this well-established marker of kidney function among persons with moderate CKD.
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- 2016
63. Biomarkers of Vitamin D Status and Risk of ESRD
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Rebholz, Casey M, Grams, Morgan E, Lutsey, Pamela L, Hoofnagle, Andrew N, Misialek, Jeffrey R, Inker, Lesley A, Levey, Andrew S, Selvin, Elizabeth, Hsu, Chi-yuan, Kimmel, Paul L, Vasan, Ramachandran S, Eckfeldt, John H, Coresh, Josef, and Consortium, Chronic Kidney Disease Biomarkers
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Aging ,Clinical Research ,Prevention ,Kidney Disease ,Nutrition ,Metabolic and endocrine ,Aged ,Biomarkers ,Case-Control Studies ,Cohort Studies ,Female ,Follow-Up Studies ,Humans ,Kidney Failure ,Chronic ,Male ,Middle Aged ,Prospective Studies ,Residence Characteristics ,Risk Factors ,Vitamin D ,Vitamin D-Binding Protein ,Biological markers ,chronic renal failure ,end-stage renal disease ,risk factors ,vitamin D-binding protein ,vitamin D ,mineral metabolism biomarker ,vitamin D insufficiency ,Chronic Kidney Disease Biomarkers Consortium ,Clinical Sciences ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundDisordered mineral metabolism is characteristic of decreased kidney function. However, the prospective associations between circulating levels of vitamin D binding protein, vitamin D, and end-stage renal disease (ESRD) have not been extensively evaluated in epidemiologic studies.Study designNested case-control study.Setting & participantsMiddle-aged black and white men and women from 4 US communities.PredictorsBaseline levels of vitamin D binding protein, 25-hydroxyvitamin D (25[OH]D), and 1,25-dihydroxyvitamin D (1,25[OH]2D) were measured in blood samples collected at study visit 4 (1996-1998) of the ARIC (Atherosclerosis Risk in Communities) Study.OutcomeESRD cases (n=184) were identified through hospitalization diagnostic codes from 1996 to 2008 and were frequency matched to controls (n=251) on categories of estimated glomerular filtration rate, albuminuria, diabetes mellitus, sex, and race.MeasurementsLogistic regression was used to estimate the association between mineral metabolism biomarkers (vitamin D binding protein, 25(OH)D, and 1,25(OH)2D) and incident ESRD, adjusting for age, sex, race, estimated glomerular filtration rate, albuminuria, diabetes mellitus, hypertension, education, specimen type, and serum levels of calcium, phosphate, and parathyroid hormone.ResultsHigher vitamin D binding protein levels were associated with elevated risk for incident ESRD (OR, 1.76; 95% CI, 1.22-2.54; P=0.003). Higher free and bioavailable 25(OH)D levels were associated with reduced risk for incident ESRD (ORs of 0.65 [95% CI, 0.46-0.92; P=0.02] and 0.63 [95% CI, 0.43-0.91; P=0.02] for free and bioavailable 25[OH]D, respectively). There was no association between ESRD and overall levels of 25(OH)D (OR, 0.83; 95% CI, 0.58-1.19; P=0.3) or 1,25(OH)2D (OR, 0.73; 95% CI, 0.48-1.13; P=0.2).LimitationsLack of direct measurement of free and bioavailable vitamin D.ConclusionsIn the general population, blood levels of vitamin D binding protein were positively associated and blood levels of free and bioavailable 25(OH)D were inversely associated with new-onset ESRD during follow-up.
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- 2016
64. The design and baseline characteristics for the HOPE Consortium Trial to reduce pain and opioid use in hemodialysis
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Dember, Laura M., primary, Hsu, Jesse Y., additional, Bernardo, Leah, additional, Cavanaugh, Kerri L., additional, Charytan, David M., additional, Crowley, Susan T., additional, Cukor, Daniel, additional, Doorenbos, Ardith Z., additional, Edwards, David A., additional, Esserman, Denise, additional, Fischer, Michael J., additional, Jhamb, Manisha, additional, Joffe, Steven, additional, Johansen, Kirsten L., additional, Kalim, Sahir, additional, Keefe, Francis J., additional, Kimmel, Paul L., additional, Krebs, Erin E., additional, Kuzla, Natalie, additional, Mehrotra, Rajnish, additional, Mishra, Puneet, additional, Pellegrino, Bethany, additional, Steel, Jennifer L., additional, Unruh, Mark L., additional, White, David M., additional, Yabes, Jonathan G., additional, and Becker, William C., additional
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- 2023
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65. Biopsies from Healthy Volunteers to Advance Precision Medicine
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Kimmel, Paul L., primary and Wendler, David S., additional
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- 2023
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66. Plasma Metabolomics of Dietary Intake of Protein-Rich Foods and Kidney Disease Progression in Children
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Ren, Xuyuehe, primary, Chen, Jingsha, additional, Abraham, Alison G., additional, Xu, Yunwen, additional, Siewe, Aisha, additional, Warady, Bradley A., additional, Kimmel, Paul L., additional, Vasan, Ramachandran S., additional, Rhee, Eugene P., additional, Furth, Susan L., additional, Coresh, Josef, additional, Denburg, Michelle, additional, and Rebholz, Casey M., additional
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- 2023
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67. Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND).
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Iyengar, Sudha K, Sedor, John R, Freedman, Barry I, Kao, WH Linda, Kretzler, Matthias, Keller, Benjamin J, Abboud, Hanna E, Adler, Sharon G, Best, Lyle G, Bowden, Donald W, Burlock, Allison, Chen, Yii-Der Ida, Cole, Shelley A, Comeau, Mary E, Curtis, Jeffrey M, Divers, Jasmin, Drechsler, Christiane, Duggirala, Ravi, Elston, Robert C, Guo, Xiuqing, Huang, Huateng, Hoffmann, Michael Marcus, Howard, Barbara V, Ipp, Eli, Kimmel, Paul L, Klag, Michael J, Knowler, William C, Kohn, Orly F, Leak, Tennille S, Leehey, David J, Li, Man, Malhotra, Alka, März, Winfried, Nair, Viji, Nelson, Robert G, Nicholas, Susanne B, O'Brien, Stephen J, Pahl, Madeleine V, Parekh, Rulan S, Pezzolesi, Marcus G, Rasooly, Rebekah S, Rotimi, Charles N, Rotter, Jerome I, Schelling, Jeffrey R, Seldin, Michael F, Shah, Vallabh O, Smiles, Adam M, Smith, Michael W, Taylor, Kent D, Thameem, Farook, Thornley-Brown, Denyse P, Truitt, Barbara J, Wanner, Christoph, Weil, E Jennifer, Winkler, Cheryl A, Zager, Philip G, Igo, Robert P, Hanson, Robert L, Langefeld, Carl D, and Family Investigation of Nephropathy and Diabetes (FIND)
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Family Investigation of Nephropathy and Diabetes ,Humans ,Diabetic Nephropathies ,Diabetes Mellitus ,Type 2 ,Genetic Predisposition to Disease ,RNA-Binding Proteins ,African Americans ,Indians ,North American ,European Continental Ancestry Group ,Hispanic Americans ,United States ,Genome-Wide Association Study ,Diabetes ,Genetics ,Human Genome ,Clinical Research ,Kidney Disease ,American Indian or Alaska Native ,Prevention ,2.1 Biological and endogenous factors ,Metabolic and endocrine ,Renal and urogenital ,Developmental Biology - Abstract
Diabetic kidney disease (DKD) is the most common etiology of chronic kidney disease (CKD) in the industrialized world and accounts for much of the excess mortality in patients with diabetes mellitus. Approximately 45% of U.S. patients with incident end-stage kidney disease (ESKD) have DKD. Independent of glycemic control, DKD aggregates in families and has higher incidence rates in African, Mexican, and American Indian ancestral groups relative to European populations. The Family Investigation of Nephropathy and Diabetes (FIND) performed a genome-wide association study (GWAS) contrasting 6,197 unrelated individuals with advanced DKD with healthy and diabetic individuals lacking nephropathy of European American, African American, Mexican American, or American Indian ancestry. A large-scale replication and trans-ethnic meta-analysis included 7,539 additional European American, African American and American Indian DKD cases and non-nephropathy controls. Within ethnic group meta-analysis of discovery GWAS and replication set results identified genome-wide significant evidence for association between DKD and rs12523822 on chromosome 6q25.2 in American Indians (P = 5.74x10-9). The strongest signal of association in the trans-ethnic meta-analysis was with a SNP in strong linkage disequilibrium with rs12523822 (rs955333; P = 1.31x10-8), with directionally consistent results across ethnic groups. These 6q25.2 SNPs are located between the SCAF8 and CNKSR3 genes, a region with DKD relevant changes in gene expression and an eQTL with IPCEF1, a gene co-translated with CNKSR3. Several other SNPs demonstrated suggestive evidence of association with DKD, within and across populations. These data identify a novel DKD susceptibility locus with consistent directions of effect across diverse ancestral groups and provide insight into the genetic architecture of DKD.
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- 2015
68. Filtration Markers as Predictors of ESRD and Mortality in Southwestern American Indians With Type 2 Diabetes
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Foster, Meredith C, Inker, Lesley A, Hsu, Chi-yuan, Eckfeldt, John H, Levey, Andrew S, Pavkov, Meda E, Myers, Bryan D, Bennett, Peter H, Kimmel, Paul L, Vasan, Ramachandran S, Coresh, Josef, Nelson, Robert G, and Consortium, CKD Biomarkers
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Clinical Research ,Prevention ,Kidney Disease ,Diabetes ,Adult ,Arizona ,Biomarkers ,Comorbidity ,Diabetes Mellitus ,Type 2 ,Diabetic Nephropathies ,Disease Progression ,Disease Susceptibility ,Ethnicity ,Female ,Follow-Up Studies ,Glomerular Filtration Rate ,Humans ,Hyperlipidemias ,Hypertension ,Indians ,North American ,Intramolecular Oxidoreductases ,Kaplan-Meier Estimate ,Kidney Failure ,Chronic ,Kidney Glomerulus ,Lipocalins ,Male ,Middle Aged ,Predictive Value of Tests ,Prospective Studies ,Risk Factors ,beta 2-Microglobulin ,Beta-trace protein ,beta-2 microglobulin ,end-stage renal disease ,type 2 diabetes mellitus ,diabetic kidney failure ,mortality ,filtration markers ,glomerular filtration rate ,kidney function ,Pima Indians ,CKD Biomarkers Consortium ,Clinical Sciences ,Public Health and Health Services ,Urology & Nephrology - Abstract
© 2015. Background: A growing number of serum filtration markers are associated with mortality and end-stage renal disease (ESRD) in adults. Whether β-trace protein (BTP) and β2-microglobulin (B2M) are associated with these outcomes in adults with type 2 diabetes is not known. Study Design: Longitudinal cohort study. Setting & Participants: 250 Pima Indians with type 2 diabetes (69% women; mean age, 42 years; mean diabetes duration, 11 years). Predictors: Serum BTP, B2M, and glomerular filtration rate measured by iothalamate clearance (mGFR) or estimated using creatinine (eGFRcr) or cystatin C level (eGFRcys). Outcomes & Measurements: Incident ESRD and all-cause mortality through December 2013. HRs were reported per interquartile range decrease of the inverse of BTP and B2M (1/BTP and 1/B2M) using Cox regression. Improvement in risk prediction with the addition of BTP or B2M level to established markers (eGFRcys with mGFR or eGFRcr) was evaluated using C statistics, continuous net reclassification improvement, and relative integrated discrimination improvement (RIDI). Results: During a median follow-up of 14 years, 69 participants developed ESRD and 95 died. Both novel markers were associated with ESRD in multivariable models. BTP level remained statistically significant after further adjustment for mGFR (1/BTP, 1.53 [95% CI, 1.01-2.30]; 1/B2M, 1.54 [95% CI, 0.98-2.42]). B2M level was associated with mortality in multivariable models and after further adjustment for mGFR (HR, 2.12; 95% CI, 1.38-3.26). The addition of B2M level to established markers increased the C statistic for mortality but only weakly when assessed by either continuous net reclassification improvement or RIDI; none was improved for ESRD by the addition of these markers. Limitations: Small sample size, single measurements of markers. Conclusions: In Pima Indians with type 2 diabetes, BTP and, to a lesser extent, B2M levels were associated with ESRD. B2M level was associated with mortality after adjustment for traditional risk factors and established filtration markers. Further studies are warranted to confirm whether inclusion of B2M level in a multimarker approach leads to improved risk prediction for mortality in this population.
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- 2015
69. Association of urinary KIM-1, L-FABP, NAG and NGAL with incident end-stage renal disease and mortality in American Indians with type 2 diabetes mellitus
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Fufaa, Gudeta D, Weil, E Jennifer, Nelson, Robert G, Hanson, Robert L, Bonventre, Joseph V, Sabbisetti, Venkata, Waikar, Sushrut S, Mifflin, Theodore E, Zhang, Xiaoming, Xie, Dawei, Hsu, Chi-yuan, Feldman, Harold I, Coresh, Josef, Vasan, Ramachandran S, Kimmel, Paul L, Liu, Kathleen D, and for the Chronic Kidney Disease Biomarkers Consortium Investigators
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Epidemiology ,Biomedical and Clinical Sciences ,Health Sciences ,Kidney Disease ,Renal and urogenital ,Good Health and Well Being ,Acute-Phase Proteins ,Adolescent ,Adult ,Aged ,Diabetes Mellitus ,Type 2 ,Diabetic Nephropathies ,Fatty Acid-Binding Proteins ,Female ,Hepatitis A Virus Cellular Receptor 1 ,Humans ,Incidence ,Indians ,North American ,Kidney Failure ,Chronic ,Lipocalin-2 ,Lipocalins ,Male ,Membrane Glycoproteins ,Middle Aged ,Neoplasm Proteins ,Proto-Oncogene Proteins ,Receptors ,Virus ,Young Adult ,Biomarkers ,End-stage renal disease ,Mortality ,Type 2 diabetes ,Chronic Kidney Disease Biomarkers Consortium Investigators ,Clinical Sciences ,Paediatrics and Reproductive Medicine ,Public Health and Health Services ,Endocrinology & Metabolism ,Clinical sciences ,Public health - Abstract
Aims/hypothesisKidney injury molecule 1 (KIM-1), liver fatty acid-binding protein (L-FABP), N-acetyl-β-D-glucosaminidase (NAG) and neutrophil gelatinase-associated lipocalin (NGAL) are urinary biomarkers of renal tubular injury. We examined their association with incident end-stage renal disease (ESRD) and all-cause mortality in American Indians with type 2 diabetes.MethodsBiomarker concentrations were measured in baseline urine samples in 260 Pima Indians who were followed for a median of 14 years. HRs were reported per SD of creatinine (Cr)-normalised log-transformed KIM-1, NAG and NGAL, and for three categories of L-FABP.ResultsDuring follow-up, 74 participants developed ESRD and 101 died. Median concentrations of KIM-1/Cr, NAG/Cr and NGAL/Cr and the proportion of detectable L-FABP were highest in those with macroalbuminuria (p
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- 2015
70. Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial
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Langefeld, Carl D, Divers, Jasmin, Pajewski, Nicholas M, Hawfield, Amret T, Reboussin, David M, Bild, Diane E, Kaysen, George A, Kimmel, Paul L, Raj, Dominic S, Ricardo, Ana C, Wright, Jackson T, Sedor, John R, Rocco, Michael V, Freedman, Barry I, and Trial, on behalf of the Systolic Blood Pressure Intervention
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Hypertension ,Cardiovascular ,Kidney Disease ,Clinical Trials and Supportive Activities ,Atherosclerosis ,Heart Disease ,Prevention ,Clinical Research ,Renal and urogenital ,Good Health and Well Being ,African Americans ,Apolipoprotein L1 ,Apolipoproteins ,Cardiovascular Diseases ,Female ,Genetic Variation ,Humans ,Lipoproteins ,HDL ,Male ,Middle Aged ,Renal Insufficiency ,Chronic ,Systolic Blood Pressure Intervention Trial ,Black or African American ,Clinical Sciences ,Urology & Nephrology - Abstract
Apolipoprotein L1 gene (APOL1) G1 and G2 coding variants are strongly associated with chronic kidney disease (CKD) in African Americans (AAs). Here APOL1 association was tested with baseline estimated glomerular filtration rate (eGFR), urine albumin:creatinine ratio (UACR), and prevalent cardiovascular disease (CVD) in 2571 AAs from the Systolic Blood Pressure Intervention Trial (SPRINT), a trial assessing effects of systolic blood pressure reduction on renal and CVD outcomes. Logistic regression models that adjusted for potentially important confounders tested for association between APOL1 risk variants and baseline clinical CVD (myocardial infarction, coronary, or carotid artery revascularization) and CKD (eGFR under 60 ml/min per 1.73 m(2) and/or UACR over 30 mg/g). AA SPRINT participants were 45.3% female with a mean (median) age of 64.3 (63) years, mean arterial pressure 100.7 (100) mm Hg, eGFR 76.3 (77.1) ml/min per 1.73 m(2), and UACR 49.9 (9.2) mg/g, and 8.2% had clinical CVD. APOL1 (recessive inheritance) was positively associated with CKD (odds ratio 1.37, 95% confidence interval 1.08-1.73) and log UACR estimated slope (β) 0.33) and negatively associated with eGFR (β -3.58), all significant. APOL1 risk variants were not significantly associated with prevalent CVD (1.02, 0.82-1.27). Thus, SPRINT data show that APOL1 risk variants are associated with mild CKD but not with prevalent CVD in AAs with a UACR under 1000 mg/g.
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- 2015
71. Sex and the kidneys: current understanding and research opportunities
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Bairey Merz, C. Noel, Dember, Laura M., Ingelfinger, Julie R., Vinson, Amanda, Neugarten, Joel, Sandberg, Kathryn L., Sullivan, Jennifer C., Maric-Bilkan, Christine, Rankin, Tracy L., Kimmel, Paul L., and Star, Robert A.
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- 2019
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72. Coping with chronic illness: The challenge of patients with renal disease
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Cukor, Daniel, primary, Cohen, Scott D., additional, and Kimmel, Paul L., additional
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- 2021
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73. Contributors
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Alshihiri, Saad, primary, Amatya, Kaushalendra, additional, Argyropoulos, Christos P., additional, Berman, Nathaniel, additional, Centron, Patricia, additional, Chilcot, Joseph, additional, Christian Cornelius, Matthew, additional, Cohen, Scott D., additional, Cukor, Daniel, additional, De Geest, Sabina M., additional, Denhaerynck, Kris, additional, Dobbels, Fabienne, additional, Engel, Kristy L., additional, Farrington, Ken, additional, Foy, Capri G., additional, Graham Ford, C., additional, Gray, Nicholas A., additional, Griva, Konstadina, additional, Hooper, Stephen R., additional, Jhamb, Manisha, additional, Johansen, Kirsten L., additional, Kimmel, Paul L., additional, Kuntz, Kristin K., additional, Levy, Norman B., additional, Lew, Susie Q., additional, Mehrotra, Rajnish, additional, Moxey-Mims, Marva M., additional, Myaskovsky, Larissa, additional, Nataatmadja, Melissa S., additional, Newman, Stanton P., additional, Norton, Jenna M., additional, Parker Gregg, L., additional, Quinn, Davin K., additional, Ribaut, Janette, additional, Roumelioti, Maria-Eleni, additional, Steel, Jennifer, additional, Susan Hedayati, S., additional, Unruh, Mark L., additional, Varma, Elly, additional, Wang, Connie J., additional, Weinman, John, additional, Wetmore, James B., additional, and Won, Alice, additional
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- 2021
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74. The landscape of psychiatric illness in CKD and ESRD
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Won, Alice, primary and Kimmel, Paul L., additional
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- 2021
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75. Anxiety in patients with CKD and ESRD
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Kimmel, Paul L., primary, Cohen, Scott D., additional, and Cukor, Daniel, additional
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- 2021
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76. Preface
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Cukor, Daniel, primary, Cohen, Scott D., additional, and Kimmel, Paul L., additional
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- 2021
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77. Blood Pressure, Sexual Activity, and Erectile Function in Hypertensive Men: Baseline Findings from the Systolic Blood Pressure Intervention Trial (SPRINT)
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Foy, Capri G., Newman, Jill C., Berlowitz, Dan R., Russell, Laurie P., Kimmel, Paul L., Wadley, Virginia G., Thomas, Holly N., Lerner, Alan J., and Riley, William T.
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- 2019
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78. Urine Stability Studies for Novel Biomarkers of Acute Kidney Injury
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Parikh, Chirag R, Butrymowicz, Isabel, Yu, Angela, Chinchilli, Vernon M, Park, Meyeon, Hsu, Chi-yuan, Reeves, W Brian, Devarajan, Prasad, Kimmel, Paul L, Siew, Edward D, Liu, Kathleen D, and Investigators, ASSESS-AKI Study
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Biomedical and Clinical Sciences ,Clinical Sciences ,Kidney Disease ,Clinical Trials and Supportive Activities ,Clinical Research ,Good Health and Well Being ,Acute Kidney Injury ,Aged ,Aged ,80 and over ,Biomarkers ,Centrifugation ,Cross-Sectional Studies ,Enzyme-Linked Immunosorbent Assay ,Female ,Freezing ,Humans ,Male ,Prospective Studies ,Urine Specimen Collection ,Proteins ,storage ,handling ,concordance ,urine biomarker ,acute kidney injury ,acute renal failure ,protein stability ,biospecimen handling ,ASSESS-AKI Study Investigators ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundThe study of novel urinary biomarkers of acute kidney injury has expanded exponentially. Effective interpretation of data and meaningful comparisons between studies require awareness of factors that can adversely affect measurement. We examined how variations in short-term storage and processing might affect the measurement of urine biomarkers.Study designCross-sectional prospective.Setting & participantsHospitalized patients from 2 sites: Yale New Haven Hospital (n=50) and University of California, San Francisco Medical Center (n=36).PredictorsWe tested the impact of 3 urine processing conditions on these biomarkers: (1) centrifugation and storage at 4°C for 48 hours before freezing at -80°C, (2) centrifugation and storage at 25°C for 48 hours before freezing at -80°C, and (3) uncentrifuged samples immediately frozen at -80°C.OutcomesUrine concentrations of 5 biomarkers: neutrophil gelatinase-associated lipocalin (NGAL), interleukin 18 (IL-18), kidney injury molecule 1 (KIM-1), liver-type fatty acid-binding protein (L-FABP), and cystatin C.MeasurementsWe measured urine biomarkers by established enzyme-linked immunosorbent assay methods. Biomarker values were log-transformed, and agreement with a reference standard of immediate centrifugation and storage at -80°C was compared using concordance correlation coefficients (CCCs).ResultsNeither storing samples at 4°C for 48 hours nor centrifugation had a significant effect on measured levels, with CCCs higher than 0.9 for all biomarkers tested. For samples stored at 25°C for 48 hours, excellent CCC values (>0.9) also were noted between the test sample and the reference standard for NGAL, cystatin C, L-FABP and KIM-1. However, the CCC for IL-18 between samples stored at 25°C for 48 hours and the reference standard was 0.81 (95% CI, 0.66-0.96).LimitationsNo comparisons to fresh, unfrozen samples; no evaluation of the effect of protease inhibitors.ConclusionsAll candidate markers tested using the specified assays showed high stability with both short-term storage at 4°C and without centrifugation prior to freezing. For optimal fidelity, urine for IL-18 measurement should not be stored at 25°C before long-term storage or analysis.
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- 2014
79. Urinary Biomarkers of Kidney Tubule Health and Mortality in Persons with CKD and Diabetes Mellitus
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Vasquez-Rios, George, primary, Katz, Ronit, additional, Levitan, Emily B., additional, Cushman, Mary, additional, Parikh, Chirag R., additional, Kimmel, Paul L., additional, Bonventre, Joseph V., additional, Waikar, Sushrut S., additional, Schrauben, Sarah J., additional, Greenberg, Jason H., additional, Sarnak, Mark J., additional, Ix, Joachim H., additional, Shlipak, Michael G., additional, and Gutierrez, Orlando M., additional
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- 2023
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80. A Genome-Wide Search for Linkage of Estimated Glomerular Filtration Rate (eGFR) in the Family Investigation of Nephropathy and Diabetes (FIND)
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Thameem, Farook, Igo, Robert P, Freedman, Barry I, Langefeld, Carl, Hanson, Robert L, Schelling, Jeffrey R, Elston, Robert C, Duggirala, Ravindranath, Nicholas, Susanne B, Goddard, Katrina A. B, Divers, Jasmin, Guo, Xiuqing, Ipp, Eli, Kimmel, Paul L, Meoni, Lucy A, Shah, Vallabh O, Smith, Michael W, Winkler, Cheryl A, Zager, Philip G, Knowler, William C, Nelson, Robert G, Pahl, Madeline V, Parekh, Rulan S, Kao, W. H. Linda, Rasooly, Rebekah S, Adler, Sharon G, Abboud, Hanna E, Iyengar, Sudha K, Sedor, John R, and Cai, Tao
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Chronic Kidney-Disease ,Renal-Function ,Mexican-Americans ,Genetic-Variants ,Serum Creatinine ,Identifies 6 ,Association ,Loci ,Albuminuria ,Traits - Published
- 2013
81. Clinical Assessment and Management of Chronic Kidney Disease Across Its Stages
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Collins, Ashte' K., primary, Rosenberg, Mark E., additional, and Kimmel, Paul L., additional
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- 2020
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82. Inflammation in Chronic Kidney Disease
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Raj, Dominic S., primary, Pecoits-Filho, Roberto, additional, and Kimmel, Paul L., additional
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- 2020
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83. Psychosocial Issues in Chronic Kidney Disease Patients
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Cukor, Daniel, primary, Halen, Nisha Ver, additional, and Kimmel, Paul L., additional
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- 2020
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84. Acute Kidney Injury and Chronic Kidney Disease
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James, Matthew T., primary, Chawla, Lakhmir S., additional, and Kimmel, Paul L., additional
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- 2020
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85. Pain and Chronic Kidney Disease
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D. Cohen, Scott, primary, Davison, Sara N., additional, and Kimmel, Paul L., additional
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- 2020
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86. Human Immunodeficiency Virus Infection and Chronic Kidney Disease
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Cohen, Scott D., primary, Kopp, Jeffrey B., additional, Cathro, Helen, additional, and Kimmel, Paul L., additional
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- 2020
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87. List of Contributors
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Abramovitz, Blaise, primary, Adu, Dwomoa, additional, Afshinnia, Farsad, additional, Agarwal, Anupam, additional, Andrews, Sarah C., additional, Appel, Gerald, additional, Bailey, James L., additional, Bakris, George L., additional, Bauer, Carolyn A., additional, Baxi, Pravir V., additional, Berns, Jeffrey S., additional, Birks, Peter, additional, Bomback, Andrew, additional, Bose, Anirban, additional, Brosius, Frank C., additional, Brown, Lee K., additional, Bushinsky, David A., additional, Busse, Laurence W., additional, Campbell, Ruth C., additional, Canney, Mark, additional, Cathro, Helen, additional, Chávez-Iñiguez, Jonathan, additional, Chawla, Lakhmir S., additional, Chen, Sheldon, additional, Chertow, Glenn M., additional, Chew, Emily Y., additional, Chonchol, Michel, additional, Clegg, Deborah J., additional, Clive, David M., additional, Clive, Pia H., additional, Cohen, Scott D., additional, Collins, Ashte' K., additional, Cooper, James E., additional, Correa-Rotter, Ricardo, additional, Cukor, Daniel, additional, Dalal, Monica, additional, Davenport, Andrew, additional, Davis, Scott, additional, Davison, Sara N., additional, Delanaye, Pierre, additional, de Zeeuw, Dick, additional, Dobre, Mirela A., additional, Drawz, Paul, additional, Ebert, Natalie, additional, Eggers, Paul, additional, Ferrè, Silvia, additional, Freedman, Barry I., additional, Furth, Susan L., additional, Gao, Bixia, additional, García-García, Guillermo, additional, Gashti, Casey N., additional, Germino, Gregory G., additional, Goldsmith, David, additional, Golestaneh, Ladan, additional, Goligorsky, Michael S., additional, Greenberg, Arthur, additional, Gregg, L. Parker, additional, Guay-Woodford, Lisa M., additional, Hamm, Lee, additional, Hart, Allyson, additional, Haselby, Danielle, additional, Hedayati, S. Susan, additional, Heerspink, Hiddo J.L., additional, Herzog, Charles A., additional, Hostetter, Thomas H., additional, House, Andrew A., additional, Hruska, Keith A., additional, Ishani, Areef, additional, Isom, Robert T., additional, James, Matthew T., additional, Jhaveri, Kenar D., additional, Johansen, Kirsten, additional, Johnson, Richard J., additional, Kang, Duk-Hee, additional, Kanno, Hiroko, additional, Kanno, Yoshihiko, additional, Karambelkar, Amrita D., additional, Karet Frankl, Fiona E., additional, Khoury, Charbel C., additional, Kimmel, Paul L., additional, Kopp, Jeffrey B., additional, Korbet, Stephen M., additional, Kruzel-Davila, Etty, additional, Kummer, Andrew, additional, LaFave, Laura, additional, Lakkis, Jay I., additional, Lerman, Lilach O., additional, Levin, Adeera, additional, Lew, Susie Q., additional, Luyckx, Valerie A., additional, Mattoo, Tej K., additional, Maynard, Sharon E., additional, McCullough, Peter A., additional, Mehrotra, Rajnish, additional, Meyer, Timothy W., additional, Mitch, William E., additional, Moe, Orson W., additional, Mohandes, Samer, additional, Moss, Alvin H., additional, Moxey-Mims, Marva, additional, Murugapandian, Sangeetha, additional, Nath, Karl A., additional, Neugarten, Joel, additional, Neyra, Javier A., additional, Nissenson, Allen R., additional, Nobakht, Ehsan, additional, Nolin, Thomas D., additional, Norris, Keith C., additional, Norton, Jenna M., additional, Nowak, Kristen L., additional, Ojo, Akinlolu O., additional, Pahl, Madeleine V., additional, Paller, Mark S., additional, Palmer, Biff F., additional, Palmer, Nicholette D., additional, Patel, Samir S., additional, Pecoits-Filho, Roberto, additional, Peitzman, Steven J., additional, Peixoto, Aldo J., additional, Pham, Phuong-Thu T., additional, Pham, Phuong-Chi T., additional, Piraino, Beth, additional, Pisoni, Roberto, additional, Rabelink, Ton, additional, Radhakrishnan, Jai, additional, Rahman, Mahboob, additional, Raj, Dominic S., additional, Ramírez-Sandoval, Juan C., additional, Rangaswami, Janani, additional, Reckelhoff, Jane F., additional, Regunathan-Shenk, Renu, additional, Reule, Scott, additional, Ronco, Claudio, additional, Rosenberg, Mark E., additional, Rosner, Mitchell H., additional, Rovin, Brad, additional, Roy-Chaudhury, Prabir, additional, Ruebner, Rebecca, additional, Rule, Andrew D., additional, Sands, Jeff M., additional, Schlanger, Lynn E., additional, Schrauben, Sarah J., additional, Seliger, Stephen, additional, Shah, Maulin, additional, Sterns, Richard H., additional, Stites, Erik, additional, Sugatani, Toshifumi, additional, Textor, Stephen C., additional, Thadhani, Ravi, additional, Thajudeen, Bijin, additional, Thakar, Surabhi, additional, Thomas, George, additional, Townsend, Raymond R., additional, Turner, Jeffrey, additional, Unruh, Mark L., additional, Urquhart, Bradley L., additional, Vassalotti, Joseph A., additional, Vaziri, Nosratola D., additional, Velasquez, Manuel T., additional, Ver Halen, Nisha, additional, Waddy, Salina P., additional, Wang, Jinwei, additional, Weber, Marc, additional, Weir, Matthew R., additional, White, Christine A., additional, Whittier, William L., additional, Williams, Matthew J., additional, Wiseman, Alexander C., additional, Wymer, David C., additional, Wymer, David T.G., additional, Yee, Jerry, additional, Zhang, Luxia, additional, Zhuang, Shougang, additional, and Ziyadeh, Fuad N., additional
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- 2020
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88. Introduction
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Kimmel, Paul L., primary and Rosenberg, Mark E., additional
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- 2020
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89. Financial accounting/ by Paul D. Kimmel, Jerry J.Weygandt & Donald E. Kieso.
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Kimmel, Paul D., Kieso, Donald E., and Weygandt, Jerry J
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Accounting ,Finance ,Financial Statements ,Reporting and Analyzing
90. Intensive systolic blood pressure control and incident chronic kidney disease in people with and without diabetes mellitus: secondary analyses of two randomised controlled trials
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Beddhu, Srinivasan, Greene, Tom, Boucher, Robert, Cushman, William C, Wei, Guo, Stoddard, Gregory, Ix, Joachim H, Chonchol, Michel, Kramer, Holly, Cheung, Alfred K, Kimmel, Paul L, Whelton, Paul K, and Chertow, Glenn M
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- 2018
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91. Genomewide linkage scan for diabetic renal failure and albuminuria: the FIND study.
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Igo, Robert P, Jr, Iyengar, Sudha K, Nicholas, Susanne B, Goddard, Katrina A B, Langefeld, Carl D, Hanson, Robert L, Duggirala, Ravindranath, Divers, Jasmin, Abboud, Hanna, Adler, Sharon G, Arar, Nedal H, Horvath, Amanda, Elston, Robert C, Bowden, Donald W, Guo, Xiuqing, Ipp, Eli, Kao, W H Linda, Kimmel, Paul L, Knowler, William C, Meoni, Lucy A, Molineros, Julio, Nelson, Robert G, Pahl, Madeline V, Parekh, Rulan S, Rasooly, Rebekah S, Schelling, Jeffrey R, Shah, Vallabh O, Smith, Michael W, Winkler, Cheryl A, Zager, Philip G, Sedor, John R, and Freedman, Barry I
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Aged ,Albuminuria: genetics ,metabolism ,Chromosome Mapping ,Diabetic Nephropathies: genetics ,metabolism ,Ethnic Groups ,Female ,Genetic Linkage ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Male ,Middle Aged ,Pedigree ,Polymorphism ,Single Nucleotide ,Renal Insufficiency: genetics ,metabolism ,Risk ,Time Factors - Abstract
Diabetic nephropathy (DN) is a leading cause of mortality and morbidity in patients with type 1 and type 2 diabetes. The multicenter FIND consortium aims to identify genes for DN and its associated quantitative traits, e.g. the urine albumin:creatinine ratio (ACR). Herein, the results of whole-genome linkage analysis and a sparse association scan for ACR and a dichotomous DN phenotype are reported in diabetic individuals.A genomewide scan comprising more than 5,500 autosomal single nucleotide polymorphism markers (average spacing of 0.6 cM) was performed on 1,235 nuclear and extended pedigrees (3,972 diabetic participants) ascertained for DN from African-American (AA), American-Indian (AI), European-American (EA) and Mexican-American (MA) populations.Strong evidence for linkage to DN was detected on chromosome 6p (p = 8.0 × 10(-5), LOD = 3.09) in EA families as well as suggestive evidence for linkage to chromosome 7p in AI families. Regions on chromosomes 3p in AA, 7q in EA, 16q in AA and 22q in MA displayed suggestive evidence of linkage for urine ACR. The linkage peak on chromosome 22q overlaps the MYH9/APOL1 gene region, previously implicated in AA diabetic and nondiabetic nephropathies.These results strengthen the evidence for previously identified genomic regions and implicate several novel loci potentially involved in the pathogenesis of DN.
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- 2011
92. The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods
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Go, Alan S, Parikh, Chirag R, Ikizler, T Alp, Coca, Steven, Siew, Edward D, Chinchilli, Vernon M, Hsu, Chi-yuan, Garg, Amit X, Zappitelli, Michael, Liu, Kathleen D, Reeves, W Brian, Ghahramani, Nasrollah, Devarajan, Prasad, Faulkner, Georgia, Tan, Thida C, Kimmel, Paul L, Eggers, Paul, Stokes, John B, and alan.s.go@kp.org
- Abstract
Abstract Background The incidence of acute kidney injury (AKI) has been increasing over time and is associated with a high risk of short-term death. Previous studies on hospital-acquired AKI have important methodological limitations, especially their retrospective study designs and limited ability to control for potential confounding factors. Methods The Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) Study was established to examine how a hospitalized episode of AKI independently affects the risk of chronic kidney disease development and progression, cardiovascular events, death, and other important patient-centered outcomes. This prospective study will enroll a cohort of 1100 adult participants with a broad range of AKI and matched hospitalized participants without AKI at three Clinical Research Centers, as well as 100 children undergoing cardiac surgery at three Clinical Research Centers. Participants will be followed for up to four years, and will undergo serial evaluation during the index hospitalization, at three months post-hospitalization, and at annual clinic visits, with telephone interviews occurring during the intervening six-month intervals. Biospecimens will be collected at each visit, along with information on lifestyle behaviors, quality of life and functional status, cognitive function, receipt of therapies, interim renal and cardiovascular events, electrocardiography and urinalysis. Conclusions ASSESS-AKI will characterize the short-term and long-term natural history of AKI, evaluate the incremental utility of novel blood and urine biomarkers to refine the diagnosis and prognosis of AKI, and identify a subset of high-risk patients who could be targeted for future clinical trials to improve outcomes after AKI.
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- 2010
93. Genome-wide Association Study for Acute Kidney Injury
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Bhatraju, Pavan K., primary, Stanaway, Ian B., additional, Palmer, Melody R., additional, Menon, Rajasree, additional, Schaub, Jennifer A., additional, Menez, Steven, additional, Srivastava, Anand, additional, Wilson, F Perry, additional, Kiryluk, Krzysztof, additional, Palevsky, Paul M., additional, Naik, Abhijit S., additional, Sakr, Sana S., additional, Jarvik, Gail P., additional, Parikh, Chirag R., additional, Ware, Lorraine B., additional, Ikizler, T. Alp, additional, Siew, Edward D., additional, Chinchilli, Vernon M., additional, Coca, Steve G., additional, Garg, Amit X., additional, Go, Alan S., additional, Kaufman, James S., additional, Kimmel, Paul L., additional, Himmelfarb, Jonathan, additional, and Wurfel, Mark M., additional
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- 2023
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94. Association of Kidney Tubule Biomarkers With Cardiac Structure and Function in the Multiethnic Study of Atherosclerosis
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Wettersten, Nicholas, primary, Katz, Ronit, additional, Greenberg, Jason H., additional, Gutierrez, Orlando M., additional, Lima, Joao A.C., additional, Sarnak, Mark J., additional, Schrauben, Sarah, additional, Deo, Rajat, additional, Bonventre, Joseph, additional, Vasan, Ramachandran S., additional, Kimmel, Paul L., additional, Shlipak, Michael, additional, and Ix, Joachim H., additional
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- 2023
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95. Assessing the Impact of Peace Building Processes.
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Kimmel, Paul R.
- Abstract
It is important for those interested in contributing to a stable world peace to focus their attention and work on positive, proactive programs that will promote peace building rather than negative, reactive programs intended to reduce violence. This paper focuses on such a training program for international negotiators. The program is intended to develop self-awareness and intercultural communication skills that will enable the negotiators to understand and collaborate with each other more effectively in future negotiations. The impact of these informed negotiations on the process of peace building is assessed. Peace building is a process that takes place through social organizations and relationships that can deal with the conflicts, stresses, and frustrations that are inevitable in international relations without resorting to violent behavior and war. (DB)
- Published
- 1991
96. Association of Obesity, Metabolic Syndrome, and Diabetes With Urinary Incontinence and Chronic Kidney Disease: Analysis of the National Health and Nutrition Examination Survey, 2003-2020.
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Chyng-Wen Fwu, Schulman, Ivonne H., Lawrence, Jean M., Kimmel, Paul L., Eggers, Paul, Norton, Jenna, Chan, Kevin, Mendley, Susan R., Barthold, Julia S., Brown, Heidi W., and McAchran, Sarah E.
- Abstract
Purpose: Diabetes and obesity, components of the metabolic syndrome (MetS), are risk factors for urinary incontinence (UI) and chronic kidney disease (CKD). We interrogated US population-based data to explore independent, sex-specific associations between nondiabetic MetS, with and without obesity, and UI and/or CKD. Materials and Methods: We analyzed data from 8586 males and 8420 females -20 years from the National Health and Nutrition Examination Survey. Multivariable logistic regression models were used to examine associations of UI or CKD with diabetes and 4 nondiabetic obesity/metabolic phenotypes: non-MetS/nonobese, MetS/nonobese, non-MetS/obese, and MetS/obese. Multinominal logistic regression models were used to assess associations of co-occurring UI/CKD with obesity/metabolic phenotypes. Results: Male MetS/obese participants had increased odds of any UI (1.25; 95% CI 1.00-1.57) and urgency UI (1.36; 1.03-1.80), compared with non-MetS/nonobese participants. Female MetS/obese participants had increased odds of any UI (2.16; 95% CI 1.76-2.66), stress UI (1.51; 1.21-1.87), and mixed UI (1.66; 1.31-2.11) compared with non-MetS/nonobese participants. The odds of cooccurring UI/CKD were increased relative to either condition alone in persons with diabetes, and in males with MetS/obese phenotypes and females with MetS phenotypes as compared to same sex participants with neither obesity nor MetS. Conclusions: We found novel associations between MetS/obese and urgency UI in males without diabetes, and between SUI and both MetS and obesity in females without diabetes. Odds estimates for UI/CKD were increased by existing obesity or MetS as compared to those for UI or CKD alone. Improved understanding of modifiable factors associated with UI will inform prevention and treatment opportunities. [ABSTRACT FROM AUTHOR]
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- 2024
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97. Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study.
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Schrauben, Sarah J, Sapa, Hima, Xie, Dawei, Zhang, Xiaoming, Anderson, Amanda Hyre, Shlipak, Michael G, Hsu, Chi-yuan, Shafi, Tariq, Mehta, Rupal, Bhat, Zeenat, Brown, Julie, Charleston, Jeanne, Chen, Jing, He, Jiang, Ix, Joachim H, Rao, Pandurango, Townsend, Ray, Kimmel, Paul L, Vasan, Ramachandran S, and Feldman, Harold I
- Subjects
DIABETIC nephropathies ,CHRONIC kidney failure ,DISEASE risk factors ,CARDIOVASCULAR diseases ,LIQUID chromatography-mass spectrometry - Abstract
Background Chronic kidney disease (CKD) is associated with atherosclerotic cardiovascular disease (ASCVD) risk, especially among those with diabetes. Altered metabolism of solutes that accumulate in CKD [asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and trimethylamine N -oxide (TMAO)] may reflect pathways linking CKD with ASCVD. Methods This case–cohort study included Chronic Renal Insufficiency Cohort participants with baseline diabetes, estimated glomerular filtration rate <60 mL/min/1.73 m
2 , and without prior history for each outcome. The primary outcome was incident ASCVD (time to first myocardial infarction, stroke or peripheral artery disease event) and secondary outcome was incident heart failure. The subcohort comprised randomly selected participants meeting entry criteria. Plasma and urine ADMA, SDMA and TMAO concentrations were determined by liquid chromatography–tandem mass spectrometry. Associations of uremic solute plasma concentrations and urinary fractional excretions with outcomes were evaluated by weighted multivariable Cox regression models, adjusted for confounding covariables. Results Higher plasma ADMA concentrations (per standard deviation) were associated with ASCVD risk [hazard ratio (HR) 1.30, 95% confidence interval (CI) 1.01–1.68]. Lower fractional excretion of ADMA (per standard deviation) was associated with ASCVD risk (HR 1.42, 95% CI 1.07–1.89). The lowest quartile of ADMA fractional excretion was associated with greater ASCVD risk (HR 2.25, 95% CI 1.08–4.69) compared with the highest quartile. Plasma SDMA and TMAO concentration and fractional excretion were not associated with ASCVD. Neither plasma nor fractional excretion of ADMA, SDMA and TMAO were associated with incident heart failure. Conclusion These data suggest that decreased kidney excretion of ADMA leads to increased plasma concentrations and ASCVD risk. [ABSTRACT FROM AUTHOR]- Published
- 2023
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98. List of Contributors
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Alexopoulos, Sophoclis, primary, Alhamed, Tarek, additional, Alicic, Radica Z., additional, Amarah, Amatur, additional, Ananthakrishnan, Shubha, additional, Arduino, Matthew J., additional, Rosenthal Asher, Deborah S., additional, Axelrod, David, additional, Balogun, Rasheed Abiodun, additional, Bargman, Joanne M., additional, Beathard, Gerald A., additional, Beaulieu, Monica C., additional, Belcher, Justin M., additional, Berns, Jeffrey S., additional, Bieber, Scott D., additional, Bloom, Roy D., additional, Blumberg, Emily A., additional, Bowman, Brendan, additional, Carrero, Juan J., additional, Cedillo-Couvert, Esteban, additional, Chan, Christopher T., additional, Chandraker, Anil, additional, Chopra, Tushar, additional, Cobo, Gabriela, additional, Cohen, Lewis M., additional, Collins, Allan J., additional, Concepcion, Beatrice P., additional, Connor, Michael J., additional, Coresh, Josef, additional, Cukor, Daniel, additional, Dawson, Solomon, additional, de Boer, Ian, additional, Denburg, Michelle, additional, Depner, Thomas A., additional, Dharnidharka, Vikas R., additional, Germain, Michael J., additional, Gill, John S., additional, Goral, Simin, additional, Grafals, Monica, additional, Graham, Judi M., additional, Hall, Gentzon, additional, Heimbürger, Olof, additional, Hingorani, Sangeeta R., additional, Hudson, Joanna Q., additional, Inker, Lesley A., additional, Jankowska, Magdalena, additional, Johnson, Emily J., additional, Johnston, Olwyn, additional, Jones, Clare B., additional, Jovanovich, Anna, additional, Kam-Tao Li, Philip, additional, Karp, Seth J., additional, Kendrick, Jessica, additional, Kimmel, Paul L., additional, Klatte, Derk C.F., additional, Knoll, Greg, additional, Kraus, Michael A., additional, Lash, James P., additional, Lentine, Krista L., additional, Levey, Andrew S., additional, Levin, Adeera, additional, Lim, Mary Ann, additional, Lindhom, Bengt, additional, Liu, Kathleen, additional, MacLaughlin, Helen, additional, Marsh, Nicola, additional, Matsuoka, Lea, additional, Mawad, Habib, additional, Mehrotra, Rajnish, additional, Moe, Sharon, additional, Najafian, Nadar, additional, Nataatmadja, Melissa, additional, Nguyen, Duc B., additional, Okusa, Mark Douglas, additional, Oliver, Matthew J., additional, Palevsky, Paul M., additional, Parikh, Chirag R., additional, Patel, Priti R., additional, Porter, Anna C., additional, Quinn, Robert R., additional, Riella, Leonardo V., additional, Rhee, Eugene P., additional, Rivara, Matthew B., additional, Rosner, Mitchell H., additional, Roumelioti, Maria-Eleni, additional, Roumeliotis, Athanasios K., additional, Sarnak, Mark J., additional, Sawinski, Deirdre, additional, Schaefer, Heidi, additional, Shafi, Tariq, additional, Sheerin, Neil, additional, Siew, Edward D., additional, Srivastava, Anand, additional, Starr, Michelle C., additional, Stenvinkel, Peter, additional, St. Peter, Wendy L., additional, Szeto, Cheuk-Chun, additional, Tolwani, Ashita J., additional, Trinh, Emilie, additional, Tuttle, Katherine R., additional, Unruh, Mark L., additional, Vella, John P., additional, Waikar, Sushrut S., additional, Yee-Moon Wang, Angela, additional, Wasse, Monnie, additional, Wazny, Lori, additional, Weiner, Daniel E., additional, Weinhandl, Eric, additional, Weiss, Jessica W., additional, Wetmore, James B., additional, Wong, Tiffany C., additional, Woodell, Tyler B., additional, Xu, Hong, additional, Yeun, Jane Y., additional, and Zalunardo, Nadia, additional
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- 2019
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99. Depression and Neurocognitive Function in Chronic Kidney Disease
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Cukor, Daniel, primary, Rosenthal Asher, Deborah S., additional, and Kimmel, Paul L., additional
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- 2019
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100. Racial disparities in poverty account for mortality differences in US medicare beneficiaries
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Kimmel, Paul L., Fwu, Chyng-Wen, Abbott, Kevin C., Ratner, Jonathan, and Eggers, Paul W.
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- 2016
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