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The construction of continuous adapted orthonormal frames along C1 closed–loop spatial curves is addressed. Such frames are important in the design of periodic spatial rigid–body motions along smooth closed paths. The construction is illustrated through the simplest non–trivial context — namely, C1 closed loops defined by a single Pythagorean–hodograph (PH) quintic space curve of a prescribed total arc length. It is shown that such curves comprise a two–parameter family, dependent on two angular variables, and they degenerate to planar curves when these parameters differ by an integer multiple of π. The desired frame is constructed through a rotation applied to the normal–plane vectors of the Euler–Rodrigues frame, so as to interpolate a given initial/final frame orientation. A general solution for periodic adapted frames of minimal twist on C1 closed–loop PH curves is possible, although this incurs transcendental terms. However, the C1 closed–loop PH quintics admit particularly simple rational periodic adapted frames.

Acral melanoma is a distinct subtype of cutaneous malignant melanoma that uniquely occurs on ultraviolet (UV)-shielded, glabrous skin of the palms, soles, and nail beds. While acral melanoma only accounts for 2–3% of all melanomas, it represents the most common subtype among darker-skinned, non-Caucasian individuals. Unlike other cutaneous melanomas, acral melanoma does not arise from UV radiation exposure and is accordingly associated with a relatively low tumor mutational burden. Recent advances in genomic, transcriptomic, and epigenomic sequencing have revealed genetic alterations unique to acral melanoma, including novel driver genes, high copy number variations, and complex chromosomal rearrangements. This review synthesizes the current knowledge on the clinical features, epidemiology, and treatment approaches for acral melanoma, with a focus on the genetic pathogenesis that gives rise to its unique tumor landscape. These findings highlight a need to deepen our genetic and molecular understanding to better target this challenging subtype of melanoma. [ABSTRACT FROM AUTHOR]

Deep convection and its vicinity are important areas of turbulence encountered in cruising aircraft, called convectively induced turbulence (CIT). In this study, deep convection area (DCA) in East Asia is identified using the infrared channel of Geostationary Korea Multi‐Purpose Satellite‐2A (GK‐2A) over 49 months (from August 2019 to August 2023), and CIT is determined by using in situ aircraft data adjacent to the DCA. Based on the satellite‐based CIT algorithm, the results indicate that 13.85%, 15.65%, and 18.23% of the total turbulence cases are classified as CIT over the Korean Peninsula, East Asia, and the full‐disk area, respectively, which are consistent with those in the previous studies. In East Asia, the CIT ratio is the highest in summer primarily due to the East Asian summer monsoon, and surprisingly, it is the second highest in winter. In winter, DCA occurs along the storm tracks accompanied by Aleutian Low, which provides favorable conditions for flights to encounter CIT in the North Pacific Ocean. The CIT intensity decreases rapidly as the horizontal distance between the DCA boundary and CIT location increases. However, at a distance exceeding 40 km from the DCA boundary, the intensity of turbulence gradually increases, which is most significant in winter. This trend is more likely related to the broader areas of DCA in the winter season than those in summer mainly due to the stronger upper‐level jet and its interaction with a storm system. Eventually, this algorithm can provide better information of avoidance guidance for CIT over the ocean. Plain Language Summary: Deep convective clouds and surrounding areas are vulnerable for encountering severe turbulence events by cruising aircraft, which often results in serious injuries and fatalities on in‐flight crews and passengers. This study uses geostationary satellite data and in situ aircraft data to identify possible areas of convectively induced turbulence (CIT) in East Asia. From the satellite‐based CIT detection algorithm, it is found that CIT events are most frequent in summer due to the East Asian summer monsoon. Surprisingly, the second peak is in winter, which is mainly driven by frequent activities of mid‐latitude cyclones in the North Pacific Ocean that affects the dominant flight routes between East Asia and North America. Eventually, the CIT detection technique will be very useful for providing better information of turbulence avoidance guidance especially over the ocean. Key Points: Convectively induced turbulence (CIT) is determined using satellite and in situ aircraft dataCIT in East Asia has the highest frequency in summer, and its intensity decreases with an increasing distance from the deep convection areaThe second‐highest frequency in winter is mainly driven by deep convections along with frontal systems in the Aleutian Low [ABSTRACT FROM AUTHOR]

Background: To investigate prenatal ultrasound findings and the chromosomal outcomes of mosaic embryo transfer. Methods: This retrospective study was conducted on pregnant women who underwent mosaic embryo transfer following blastocyst-stage preimplantation genetic testing for aneuploidy (PGT-A) at CHA Gangnam Medical Center from January 2021 to July 2024. Trophectoderm biopsy specimens were collected using standard protocols, and next-generation sequencing profiles were defined as mosaics when displaying copy number counts in the 20–80% range. The results of the PGT-A, the amniocentesis results, the findings of prenatal ultrasounds, and the pregnancy outcomes were analyzed. Results: A total of 88 mosaic embryos were transferred, of which 77 embryos were successfully implanted. Sixty-seven embryo-maintained pregnancies went beyond 11 weeks (87.0%), all among 58 patients with singleton pregnancies. The chaotic subtype showed the lowest ongoing pregnancy rate, and high-level mosaicism was less frequent in the ongoing group, compared to the total study group and the successful implantation group. Amniocentesis was performed on 33 mothers (56.9%), revealing two cases with abnormal findings that did not correlate with the PGT-A results. Two cases showed abnormalities in the second trimester detailed ultrasound, and both subsequently demonstrated normal findings in the third trimester and after birth. The average gestational age at birth was 38.4 weeks, and the average birth weight was 3313 g. No congenital anomalies were detected in 16 postnatal cases. Conclusions: Our study indicated that mosaic embryos can develop into euploid healthy infants with various levels or types of mosaicism, although the postnatal follow-up data are limited. This study is invaluable for counseling clinical results after mosaic embryo transfer, reassuring that, if patients do not have euploid embryos available, mosaic embryos can also be a viable option for transfer. [ABSTRACT FROM AUTHOR]

Apios is a legume known to be nutrient dense. However, it is difficult for older adults to consume due to chewing difficulties. In this study, we analyzed its nutritional contents and antioxidant capacity and improved its texture through enzymatic treatment (polygalacturonase, cellulase, and α-amylase) to make it more palatable for older adults. Apios has been shown to have higher antioxidant capacity than other tubers, which is beneficial for geriatric health. Enzyme treatment (ETG1 7.12 h, ETG2 9.64 h, ETG3 over 6.48 h) made the texture suitable for consumption by the elderly. SEM analysis showed that the pore size increased and the cell wall was disrupted, resulting in irregular cell tissues. These changes can facilitate mastication and improve nutrient intake. Therefore, the enzyme-treated Apios is easy to chew, so it will be able to improve the intake of nutrients that the elderly need. In addition, it is expected to contribute to the expansion of the elder-friendly food industry by applying enzyme treatment to personalized food development considering different chewing abilities of the elderly. [ABSTRACT FROM AUTHOR]

Vancomycin-variable enterococci (VVE), though genetically containing van genes, are phenotypically sensitive to vancomycin. If VVE is undetected or does not grow on the vancomycin-resistant enterococci (VRE) selection medium, or both, it can acquire resistance upon exposure to vancomycin. This characteristic is clinically important for the treatment and prevention of VRE. This study aims to analyze the prevalence and characteristics of VVE in Korea through the Global Antibiotic Resistance Surveillance System (Kor-GLASS) and emphasize the importance of VVE. A total of 3342 enterococcal bloodstream isolates were collected through the Kor-GLASS between 2017 and 2022. Antibiotic susceptibility testing, van gene detection, and multilocus sequence typing were conducted with all the isolates. The trends in the domestic prevalence of VVE were analyzed and compared with global prevalence data. Among the isolates, 197 (5.9%), including 124 Enterococcus faecium and 73 E. faecalis, were identified as VVE. While the VRE incidence has declined in Korea since 2020, the VVE incidence is significantly rising. In Korea, only the vanA gene has been detected in both VRE and VVE, and no other van gene variants have been identified. Most of these isolates belong to CC17 (91.3%), with ST17, ST817, and ST80 as the predominant types. We have shown that continuous surveillance is essential in Korea due to the persistently high prevalence of VRE and the potential evolution of VVE into VRE. Consequently, it is critical to evaluate Enterococcus species isolated from domestic clinical settings for their phenotypic vancomycin resistance and the molecular detection of van genes, irrespective of the strain. [ABSTRACT FROM AUTHOR]

For liquid organic hydrogen carrier (LOHC) technology to be competitive with other H2‐storage methods, it is crucial to reduce the cost of LOHC materials occupying the high proportion of the embodied energy required for system implementation. Promising approaches are to convert crude or waste feedstock into LOHC materials and to utilize crude hydrogen sources obtained from various routes. Thus, in this review, the state‐of‐the‐art advances in sustainable LOHC‐based hydrogen storage using crude or waste feedstock, associated with their conversion into LOHC materials, and coupling crude hydrogen with LOHC system to obtain high‐purity H2 without separation and purification are highlighted. Petroleum sources like light cycle oil and pyrolysis fuel oil are used after liquid–liquid extraction, combined distillation/hydroprocessing, and one‐pot hydrotreating–hydrocracking. In case of converting renewable resources (e.g., biomass and plastic waste), depolymerization followed by hydrodeoxygenation is an effective approach. To utilize crude hydrogen sources for hydrogen storage, catalysts should be designed and synthesized toward activating LOHC hydrogenation reaction at lower temperatures, along with high CO resistance. Consequently, this context provides guidance for the development of LOHC technology to accelerate its commercialization. [ABSTRACT FROM AUTHOR]

With the rapid acceleration of the Fourth Industrial Revolution, cyber threats have become increasingly frequent and complex. However, most public and private institutions still rely heavily on manual cybersecurity operations, which often lead to delayed responses and human errors, exposing critical vulnerabilities. A particular challenge lies in the inability to efficiently integrate and automate the analysis of threat logs collected from various sources, limiting the effectiveness of threat prediction and mitigation. To address these challenges, this study proposes an AI-based RPA (Robotic Process Automation) system designed to automate the collection, analysis, and dissemination of cyber threat logs. By minimizing human intervention, the proposed system significantly enhances real-time response capabilities and reduces errors. Additionally, standardizing and centralizing diverse log formats lays a foundation for the future development of AI models capable of predicting cyberattack patterns. This system is particularly well-suited for government and public organizations, offering a cost-effective solution that enhances cybersecurity while maintaining compatibility with existing infrastructures. The experimental results demonstrate that the proposed AI-based RPA system outperforms traditional manual systems in terms of log processing speed, prediction accuracy, and error reduction. This study highlights the critical role of automated AI-driven systems in enabling real-time threat response and prevention, presenting a practical and scalable approach for modern cybersecurity environments. [ABSTRACT FROM AUTHOR]

Neonatal chylothorax is a potentially fatal respiratory condition caused by a congenital or traumatic etiology. Conventional therapies, such as fasting, total parenteral nutrition, and intravenous octreotide, are generally successful in such cases; however, more invasive therapeutic measures, such as pleurodesis, should be considered in refractory cases. This case report presents two preterm infants with refractory chylothorax who were non-responsive to conventional treatment but were successfully managed using hypertonic glucose pleurodesis. The first case was that of a female infant born at 24+5 weeks of gestation (585 g) and diagnosed with postsurgical chylothorax at 68 days of life. Even after the initiation of fasting and intravenous octreotide administration, pleural drainage did not reduce. Therefore, the patient underwent three intermittent procedures of 50% glucose pleurodesis, which resulted in the resolution of the chylothorax and subsequent chest tube removal after 37 days. The second case was a female infant born at 34+6 weeks (3,040 g), who was diagnosed with congenital chylothorax immediately after birth. Fasting and intravenous octreotide failed to show any clinical effects; therefore, the patient underwent pleurodesis for 3 consecutive days. After the procedure, the amount of pleural drainage substantially decreased, and the chest tube was removed after 14 days. In both cases, a temporal relation between pleurodesis and chylothorax resolution was observed, suggesting that hypertonic glucose pleurodesis may be an effective and safe alternative for treating refractory chylothorax in preterm infants with minimal side effects. Further studies are needed to establish the optimal protocol for this procedure and to compare its efficacy with that of other pleurodesis agents. [ABSTRACT FROM AUTHOR]