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57. List of Contributors

Author

Amaya, Luis, primary, Ashworth, Jane L, additional, Avery, Robert A, additional, Bartram, Jack, additional, Beres, Shannon J, additional, Binenbaum, Gil, additional, Biousse, Valérie, additional, Birch, Eileen E, additional, Biswas, Susmito, additional, Black, Graeme C M, additional, Black, Joanna, additional, Bowman, Richard J C, additional, Bradbury, John A, additional, Brodsky, Michael C, additional, Brosnahan, Donal, additional, de Alba, Alejandra, additional, Camuglia, Jayne E, additional, Carden, Susan M, additional, Castano, Giovanni, additional, Casteels, Ingele, additional, Chung, Yvonne, additional, Clarke, Michael P, additional, Coats, David K, additional, Collin, Richard, additional, Crompton, John, additional, Cunningham, Emmett T, additional, Demer, Joseph L, additional, Dollfus, Hélène, additional, Dolman, Peter J, additional, Donahue, Sean P, additional, Edelsten, Clive, additional, Fielder, Alistair R, additional, FitzPatrick, David R., additional, Fulton, Anne B, additional, Gallie, Brenda L, additional, Geloneck, Megan, additional, Gilbert, Clare E, additional, Giligson, Christy, additional, Gole, Glen A, additional, Good, William V, additional, Grigg, John R B, additional, Grossniklaus, Hans, additional, Hamel, Patrick, additional, Handler, Sheryl M, additional, Hansen, Ronald M, additional, Heidary, Gena, additional, Hertle, Richard W, additional, Hildebrand, Göran Darius, additional, Holder, Graham E, additional, Hoyt, Creig S, additional, Hubbard, G Baker, additional, Hutchinson, Amy K, additional, Jain, Saurabh, additional, Jamieson, Robyn V, additional, Jensen, Hanne, additional, Kadom, Nadja, additional, Kekunnaya, Ramesh, additional, Kersten, Robert C, additional, Kestelyn, Philippe, additional, Keunen, Jan E E, additional, Khaw, Peng Tee, additional, Kim, Chong Ae, additional, Koopman, Jan, additional, Kraft, Stephen P, additional, Kushner, Burton J, additional, Lambert, Scott R, additional, LaRoche, G Robert, additional, Larsen, Dorte Ancher, additional, Lee, Andrew G, additional, Lee, Barry, additional, Lenhart, Phoebe, additional, Liasis, Alki, additional, Liu, Grant T, additional, Lloyd, Christopher, additional, Lyons, Christopher J, additional, Matsuba, Carey A, additional, MacEwen, Caroline J, additional, McNab, Alan A, additional, Mehta, Vaishali, additional, Michaelides, Michel, additional, Mojon, Daniel, additional, Ulrik, Hans, additional, Moore, Anthony T, additional, Morris, Andrew A M, additional, Newman, Nancy J, additional, Nischal, Ken K, additional, O'Colmain, Una, additional, O'Connor, Anna R, additional, O'Keefe, Michael, additional, Olitsky, Scott E, additional, Ospina, Luis H, additional, Oystreck, Darren T, additional, Papadopoulos, Maria, additional, Park, Sunju, additional, Paysse, Evelyn A, additional, Peragallo, Jason H, additional, Pereira, Erika Mota, additional, Pilling, Rachel F, additional, Pineles, Stacy, additional, Prajna, Venkatesh, additional, Proudlock, Frank Antony, additional, Puvanachandra, Narman, additional, Quinn, Anthony G, additional, Quinn, Graham E, additional, Rahi, Jugnoo S, additional, Repka, Michael X, additional, Robinson, Joshua, additional, Russell, Buddy, additional, de Sá, Luis Carlos Ferreira, additional, Sachdeva, Virender, additional, Salchow, Daniel J, additional, Scawn, Richard L, additional, Schalij-Delfos, Nicoline, additional, van Schooneveld, Mary J, additional, Self, Jay, additional, Sergouniotis, Panagiotis I, additional, Shields, Carol L, additional, Shields, Jerry A, additional, Sloper, John J, additional, Snead, Martin P, additional, Soliman, Sameh E, additional, Sullivan, Timothy John, additional, Summers, C Gail, additional, Tan, Kimberley, additional, Taylor, David S, additional, Thompson, Dorothy A, additional, Traboulsi, Elias I, additional, Tuft, Stephen J, additional, Uddin, Jimmy M, additional, Vijayalakshmi, Perumalsamy, additional, Watts, Patrick, additional, Weakley, David R, additional, and Wells, Jill Razor, additional

Published
2017
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60. Scoping Review Protocol_Version 1.10

Author

Piyasena, Mapa, Aghaji, Ada, Christin, Henein, Rono, Hilary, Bastawrous, Andrew, Khaw, Peng, West, Sheila, Bourne, Rupert, Congdon, Nathan, and Burton, Matthew

Subjects
Latent Eye Diseases, Eye Diseases Screening, Eye Care Burden Estimation, Eye Health Burden, Quality of Life in Eye Health, Non-Visually Impairing Ocular
Published
2022
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61. Systematic Analysis of Non-Visually Impairing Ocular Conditions: Protocol for a Scoping Review

Author

Piyasena, Mapa, Aghaji, Ada, Christin, Henein, Rono, Hilary, Bastawrous, Andrew, Khaw, Peng, West, Sheila, Bourne, Rupert, Burton, Matthew, and Congdon, Nathan

Subjects
Hardware_MEMORYSTRUCTURES, Non-Visual Ocular Conditions, genetic structures, Eye Health Burden Estimation, Eye Diseases Screening, Eye Care Burden Estimation, Life Sciences, Eye Health Burden, Quality of Life in Eye Health, Social and Behavioral Sciences, eye diseases, Eye Disease Global Burden, Latent Eye Diseases, Medicine and Health Sciences, sense organs, Non-Visually Impairing Ocular
Abstract

The proposed scoping review protocol attached in the OSF web-site and publicly available only for reference.

Published
2022
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70. Transcriptomics of CD29+/CD44+ cells isolated from hPSC retinal organoids reveals a single cell population with retinal progenitor and Müller glia characteristics.

Author

Eastlake, Karen, Luis, Joshua, Wang, Weixin, Lamb, William, Khaw, Peng T., and Limb, G. Astrid

Subjects
CELL populations, ORGANOIDS, RETINAL diseases, GENE expression, RETINA
Abstract

Müller glia play very important and diverse roles in retinal homeostasis and disease. Although much is known of the physiological and morphological properties of mammalian Müller glia, there is still the need to further understand the profile of these cells during human retinal development. Using human embryonic stem cell-derived retinal organoids, we investigated the transcriptomic profiles of CD29+/CD44+ cells isolated from early and late stages of organoid development. Data showed that these cells express classic markers of retinal progenitors and Müller glia, including NFIX, RAX, PAX6, VSX2, HES1, WNT2B, SOX, NR2F1/2, ASCL1 and VIM, as early as days 10–20 after initiation of retinal differentiation. Expression of genes upregulated in CD29+/CD44+ cells isolated at later stages of organoid development (days 50–90), including NEUROG1, VSX2 and ASCL1 were gradually increased as retinal organoid maturation progressed. Based on the current observations that CD24+/CD44+ cells share the characteristics of early and late-stage retinal progenitors as well as of mature Müller glia, we propose that these cells constitute a single cell population that upon exposure to developmental cues regulates its gene expression to adapt to functions exerted by Müller glia in the postnatal and mature retina. [ABSTRACT FROM AUTHOR]

Published
2023
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74. Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia

Author

Hysi, Pirro G, Choquet, Hélène, Khawaja, Anthony P, Wojciechowski, Robert, Tedja, Milly S, Yin, Jie, Simcoe, Mark J, Patasova, Karina, Mahroo, Omar A, Thai, Khanh K, Cumberland, Phillippa M, Melles, Ronald B, Verhoeven, Virginie JM, Vitart, Veronique, Segre, Ayellet, Stone, Richard A, Wareham, Nicholas, Hewitt, Alex W, Mackey, David A, Klaver, Caroline CW, MacGregor, Stuart, Error, Consortium For Refractive, Khaw, Peng T, Foster, Paul J, Eye, UK, Guggenheim, Jeremy A, 23andMe Inc., Rahi, Jugnoo S, Jorgenson, Eric, Hammond, Christopher J, Apollo-University Of Cambridge Repository, Hysi, Pirro G [0000-0001-5752-2510], Choquet, Hélène [0000-0001-9839-8667], Khawaja, Anthony P [0000-0001-6802-8585], Wojciechowski, Robert [0000-0002-9593-4652], Tedja, Milly S [0000-0003-0356-9684], Simcoe, Mark J [0000-0003-2432-0810], Verhoeven, Virginie JM [0000-0001-7359-7862], Vitart, Veronique [0000-0002-4991-3797], Hewitt, Alex W [0000-0002-5123-5999], Klaver, Caroline CW [0000-0002-2355-5258], MacGregor, Stuart [0000-0001-6731-8142], Khaw, Peng T [0000-0002-8087-2268], Foster, Paul J [0000-0002-4755-177X], Guggenheim, Jeremy A [0000-0001-5164-340X], Jorgenson, Eric [0000-0002-5829-8191], Hammond, Christopher J [0000-0002-3227-2620], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, genetic structures, Consortium for Refractive Error and Myopia, European Continental Ancestry Group, Middle Aged, Refractive Errors, Polymorphism, Single Nucleotide, eye diseases, White People, 23andMe Inc, UK Eye and Vision Consortium, Myopia, Humans, Genetic Predisposition to Disease, Female, Aged, Genome-Wide Association Study
Abstract

Refractive errors, in particular myopia, are a leading cause of morbidity and disability worldwide. Genetic investigation can improve understanding of the molecular mechanisms that underlie abnormal eye development and impaired vision. We conducted a meta-analysis of genome-wide association studies (GWAS) that involved 542,934 European participants and identified 336 novel genetic loci associated with refractive error. Collectively, all associated genetic variants explain 18.4% of heritability and improve the accuracy of myopia prediction (area under the curve (AUC) = 0.75). Our results suggest that refractive error is genetically heterogeneous, driven by genes that participate in the development of every anatomical component of the eye. In addition, our analyses suggest that genetic factors controlling circadian rhythm and pigmentation are also involved in the development of myopia and refractive error. These results may enable the prediction of refractive error and the development of personalized myopia prevention strategies in the future.

Published
2021
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76. Grand Challenges in global eye health: a global prioritisation process using Delphi method

Author

Ramke, Jacqueline, primary, Evans, Jennifer R, additional, Habtamu, Esmael, additional, Mwangi, Nyawira, additional, Silva, Juan Carlos, additional, Swenor, Bonnielin K, additional, Congdon, Nathan, additional, Faal, Hannah B, additional, Foster, Allen, additional, Friedman, David S, additional, Gichuhi, Stephen, additional, Jonas, Jost B, additional, Khaw, Peng T, additional, Kyari, Fatima, additional, Murthy, Gudlavalleti V S, additional, Wang, Ningli, additional, Wong, Tien Y, additional, Wormald, Richard, additional, Yusufu, Mayinuer, additional, Taylor, Hugh, additional, Resnikoff, Serge, additional, West, Sheila K, additional, Burton, Matthew J, additional, Aghaji, Ada, additional, Adewole, Adeyemi T, additional, Csutak, Adrienne, additional, Salam, Ahmad Shah, additional, Paduca, Ala, additional, Bron, Alain M, additional, Denniston, Alastair K, additional, Lazo Legua, Alberto, additional, Halim, Aldiana, additional, Tefera, Alemayehu Woldeyes, additional, Mwangi, Alice, additional, Jenkins, Alicia J, additional, Davis, Amanda, additional, Meddeb-Ouertani, Amel, additional, Wali, Amina H, additional, Palis, Ana G, additional, Bastos de Carvalho, Ana, additional, Joshi, Anagha, additional, Kreis, Andreas J, additional, Mueller, Andreas, additional, Bastawrous, Andrew, additional, Cooper, Andrew, additional, Smith, Andrew F, additional, Grzybowski, Andrzej, additional, Arvind, Anitha, additional, Karanu, Anne M, additional, Orlina, Anne O, additional, Burnett, Anthea, additional, Yashadhana, Aryati, additional, Abeydeera, Asela P, additional, Abdurakhmanova, Aselia, additional, Mohamed, Ashik, additional, Bacchav, Ashish, additional, Bernhisel, Ashlie, additional, Webson, Aubrey Walton, additional, Azuara-Blanco, Augusto, additional, Hossain, Ava, additional, Ilhan, Bayazit, additional, Assumpta Lucienne, Bella, additional, Tousignant, Benoit, additional, Shamanna, Bindiganavale R, additional, Wiafe, Boateng, additional, Mueller, Brigitte, additional, Caglar, Cagatay, additional, Mpyet, Caleb, additional, Abraham, Carl H, additional, Cheung, Carol Y, additional, Thiel, Cassandra L, additional, Jan, Catherine L, additional, Emedike, Chike, additional, Chuluunkhuu, Chimgee, additional, Chinyere, Chinomso, additional, Henein, Christin, additional, Gilbert, Clare E, additional, Bascaran, Covadonga, additional, Nitulescu, Cristina Elena, additional, Patel, Daksha, additional, Bachani, Damodar, additional, Kiage, Daniel, additional, Etya'ale, Daniel, additional, Dahdal, David, additional, Woo Lawson, Dawn, additional, Godin, Denise, additional, Nkanga, Dennis G, additional, Ondeyo, Dennis M, additional, O'Brien, Donna, additional, Mutie, Dorothy M, additional, Alalawi, Ebtisam S K, additional, Mayorga, Eduardo, additional, Bin Hashim, Effendy, additional, Ashrafi, Elham, additional, Kishiki, Elizabeth Andrew, additional, Kurian, Elizabeth, additional, D'Esposito, Fabrizio, additional, Masila, Faith, additional, Pena, Fernando Yaacov, additional, Büsch, Fortunat, additional, Topouzis, Fotis, additional, Bandello, Francesco, additional, Oyediji, Funmilayo J, additional, Thumann, Gabriele, additional, Ezz Elarab, Gamal, additional, Kitema, Gatera Fiston, additional, Schlenther, Gerhard, additional, Fefoame, Gertrude Oforiwa, additional, Cochrane, Gillian M, additional, Laganovska, Guna, additional, Awan, Haroon R, additional, Ansari, Harris M, additional, Philippin, Heiko, additional, Burn, Helen, additional, Dimaras, Helen, additional, Filipe, Helena P, additional, Monye, Henrietta I, additional, Kandel, Himal, additional, Randrianarisoa, Hoby Lalaina, additional, Jones, Iain, additional, Murdoch, Ian E, additional, Fabian, Ido Didi, additional, Khan, Imran A, additional, Sharma, Indra P, additional, Elbeih, Islam, additional, Mactaggart, Islay, additional, Pastor, J Carlos, additional, Keunen, Jan E E, additional, Ohuma, Jane A, additional, Pithuwa Nirwoth, Jason, additional, Hammou, Jaouad, additional, Vianna, Jayme R, additional, Biao, Jean-eudes, additional, Burr, Jennifer M, additional, Keenan, Jeremy D, additional, Blijkers, Jess, additional, Black, Joanna M, additional, Barbosa Breda, Joao, additional, Furtado, Joao M, additional, Buchan, John C, additional, Lawrenson, John G, additional, Kempen, John H, additional, Ehrlich, Joshua R, additional, Stern, Judith, additional, Zhang, Justine H, additional, Keskinbora, Kadircan H, additional, Knoll, Karin M, additional, Blanchet, Karl, additional, Schmid, Katrina L, additional, Ono, Koichi, additional, Ogundimu, Kolawole, additional, Balo, Komi, additional, Somda, Kussome Paulin, additional, Yeboah, Kwame, additional, Amissah-Arthur, Kwesi N, additional, Nasehi, Leone, additional, Øverland, Lene, additional, Vijaya, Lingam, additional, Keay, Lisa, additional, Hamm, Lisa M, additional, Mowatt, Lizette, additional, Harrison-Williams, Lloyd C M, additional, Silva, Lucia, additional, Bilotto, Luigi, additional, Mörchen, Manfred, additional, Rabiu, Mansur, additional, Zondervan, Marcia, additional, Chagunda, Margarida, additional, Sandinha, Maria Teresa, additional, Yee Melgar, Mariano, additional, Salas Vargas, Marisela, additional, Daniell, Mark D, additional, Katibeh, Marzieh, additional, Broom, Matt, additional, Collins, Megan E, additional, Alp, Mehmet Numan, additional, Kwarteng, Michael A, additional, Belkin, Michael, additional, Gichangi, Michael, additional, Sylvanowicz, Michelle, additional, Wu, Min, additional, Cano, Miriam R, additional, Shalaby, Mohammad, additional, Duggal, Mona, additional, Khairallah, Moncef, additional, Batur, Muhammed, additional, Bikbov, Mukharram M, additional, Ramappa, Muralidhar, additional, Pamarathi, Nagaraju, additional, Khachatryan, Naira, additional, Muhammad, Nasiru, additional, Kennedy, Neil, additional, Murray, Neil, additional, Beare, Nicholas A V, additional, Astbury, Nick, additional, Carnt, Nicole A, additional, St Rose, Nigel A, additional, Barker, Nigel H, additional, Pehere, Niranjan K, additional, Uche, Nkechinyere J, additional, Lois, Noemi, additional, Awe, Oluwaseun O, additional, Mujica, Oscar J, additional, Okolo, Oteri E, additional, Rani, Padmaja Kumari, additional, Ruamviboonsuk, Paisan, additional, Ndiaye, Papa Amadou, additional, Dhakhwa, Parami, additional, Rozsival, Pavel, additional, Mbulawa, Pearl K, additional, Keane, Pearse A, additional, Jones, Pete R, additional, Holland, Peter, additional, Nukella, Phanindra Babu, additional, Burgess, Philip I, additional, O'Dwyer, Pinar Aydin, additional, Piyasena, Prabhath, additional, Bastola, Pradeep, additional, Morjaria, Priya, additional, Nasimee, Qais, additional, Rambacal, Raizza A T, additional, Das, Rajdeep, additional, Khandekar, Rajiv B, additional, Azad, Rajvardhan, additional, Bashshur, Ramona, additional, Sousa, Raúl A R C, additional, Oenga, Rebecca, additional, Gurung, Reeta, additional, Geneau, Robert, additional, Jacobs, Robert J, additional, Finger, Robert P, additional, Guymer, Robyn H, additional, Sevciuc, Rodica, additional, Khanna, Rohit C, additional, George, Ronnie, additional, Graham, Ronnie, additional, Kawasaki, Ryo, additional, Ho, S May, additional, Mishra, Sailesh Kumar, additional, Buttan, Sandeep, additional, Block, Sandra S, additional, Talero, Sandra, additional, Yoon, Sangchul, additional, Joseph, Sanil, additional, Safi, Sare, additional, Dodson, Sarity, additional, Munoz, Sergio R, additional, Bakayoko, Seydou, additional, Mohammadi, Seyed Farzad, additional, Muez, Shabir Ahmad, additional, Pardhan, Shahina, additional, Hopkins, Shelley, additional, Sheu, Shwu-Jiuan, additional, Coulibaly, Sidi Mohamed, additional, Schellini, Silvana A, additional, Arunga, Simon, additional, Bush, Simon R, additional, Sivaprasad, Sobha, additional, Salomao, Solange R, additional, Marmamula, Srinivas, additional, Onwubiko, Stella N, additional, Misra, Stuti L, additional, Kuyyadiyil, Subeesh, additional, Kulkarni, Sucheta, additional, khanal, Sudarshan, additional, Yasmin, Sumrana, additional, Pavljasevic, Suzana Nikolic, additional, Gilbert, Suzanne S, additional, Braithwaite, Tasanee, additional, Ghidirimschi, Tatiana, additional, Ravilla, Thulasiraj, additional, Fricke, Timothy R, additional, Cogliati, Tiziana, additional, Kassa, Tsehaynesh, additional, Peto, Tunde, additional, Dibb, Ute, additional, Lansingh, Van C, additional, Hu, Victor H, additional, Sheffield, Victoria M, additional, Mathenge, Wanjiku, additional, Dean, William H, additional, Nolan, Winifred, additional, Hiratsuka, Yoshimune, additional, Mahsood, Yousaf Jamal, additional, and Sapkota, Yuddha, additional

Published
2022
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78. Future Strategies

Author

Khaw, Peng Tee, primary, Lockwood, Alastair, additional, Georgoulas, Stelios, additional, Dahlmann-Noor, Annegret H, additional, and Brocchini, Stephen, additional

Published
2015
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80. Authors' reply

Author

Khaw, Peng Tee, Shah, Peter, and Elkington, Andrew R

Published
2004

90. Trabeculectomy

Author

Khaw, Peng, primary, Shah, Peter, additional, Sii, Freda, additional, and Abbott, Joseph, additional

Published
2014
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92. Foveal structure and visual function in nanophthalmos and posterior microphthalmos

Author

Müller, Philipp L, primary, Treis, Tim, additional, Alsaedi, Abdulrahman, additional, Webster, Andrew R, additional, Khaw, Peng, additional, Michaelides, Michel, additional, Wickham, Louisa, additional, Siriwardena, Dilani, additional, Foster, Paul, additional, Moosajee, Mariya, additional, Pavesio, Carlos, additional, Tufail, Adnan, additional, and Egan, Catherine, additional

Published
2021
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94. Alcohol Consumption and Incident Cataract Surgery in Two Large UK Cohorts

Author

Chua, Sharon Y.L., primary, Luben, Robert N., additional, Hayat, Shabina, additional, Broadway, David C., additional, Khaw, Kay-Tee, additional, Warwick, Alasdair, additional, Britten, Abigail, additional, Day, Alexander C., additional, Strouthidis, Nicholas, additional, Patel, Praveen J., additional, Khaw, Peng T., additional, Foster, Paul J., additional, and Khawaja, Anthony P., additional

Published
2021
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95. Retinal asymmetry in multiple sclerosis

Author

Petzold, Axel, Chua, Sharon Y. L., Khawaja, Anthony P., Keane, Pearse A., Khaw, Peng T., Reisman, Charles, Dhillon, Baljean, Strouthidis, Nicholas G., Foster, Paul J., Patel, Praveen J., Atan, Denize, Aslam, Tariq, Barman, Sarah A., Barrett, Jenny H., Bishop, Paul, Bunce, Catey, Carare, Roxana O., Chakravarthy, Usha, Chan, Michelle, Crabb, David P., Day, Alexander, Desai, Parul, Dhillon, Bal, Dick, Andrew D., Egan, Cathy, Ennis, Sarah, Fruttiger, Marcus, Gallacher, John E. J., Garway-Heath, David F., Gibson, Jane, Gore, Dan, Guggenheim, Jeremy A., Hammond, Chris J., Hardcastle, Alison, Harding, Simon P., Hogg, Ruth E., Hysi, Pirro, Khaw, Sir Peng T., Lascaratos, Gerassimos, Lotery, Andrew J., MacGillivray, Tom, MacKie, Sarah, McGaughey, Michelle, McGuinness, Bernadette, McKay, Gareth J., McKibbin, Martin, Moore, Tony, Morgan, James E., Muthy, Zaynah A., O'Sullivan, Eoin, Owen, Chris G., Patel, Praveen, Paterson, Euan, Peto, Tunde, Rahi, Jugnoo S., Rudnikca, Alicja R., Self, Jay, Sivaprasad, Sobha, Steel, David, Stratton, Irene, Strouthidis, Nicholas, Sudlow, Cathie, Thomas, Dhanes, Trucco, Emanuele, Tufail, Adnan, Vitart, Veronique, Vernon, Stephen A., Viswanathan, Ananth C., Williams, Cathy, Williams, Katie, Woodside, Jayne V., Yates, Max M., Zheng, Yalin, Consortium, UK Biobank Eye and Vision, Gallacher, JE, Neurology, Ophthalmology, APH - Mental Health, APH - Methodology, and Amsterdam Neuroscience - Neuroinfection & -inflammation

Subjects
Male, genetic structures, Youden's J statistic, Optic neuritis, Imaging, chemistry.chemical_compound, 0302 clinical medicine, medicine.diagnostic_test, AcademicSubjects/SCI01870, imaging, Middle Aged, Biobank, Female, demyelination, Demyelination, Tomography, Optical Coherence, medicine.medical_specialty, Multiple Sclerosis, Clinical Neurology, Sensitivity and Specificity, Retina, Multiple sclerosis, 03 medical and health sciences, Optical coherence tomography, SDG 3 - Good Health and Well-being, Ophthalmology, medicine, Humans, optic neuritis, Research ethics, Community level, Neuromyelitis optica, Receiver operating characteristic, business.industry, biomarkers, Retinal, Original Articles, medicine.disease, Confidence interval, eye diseases, chemistry, North west, 030221 ophthalmology & optometry, Optometry, AcademicSubjects/MED00310, RE, Neurology (clinical), sense organs, business, 030217 neurology & neurosurgery, Biomarkers, RC
Abstract

In a large community-based study, Petzold et al. show that optical coherence tomography measures of retinal asymmetry have high diagnostic sensitivity for multiple sclerosis, particularly in younger individuals without relevant comorbidities. The technique should be considered in future revisions of diagnostic criteria., The diagnosis of multiple sclerosis is based on a combination of clinical and paraclinical tests. The potential contribution of retinal optical coherence tomography (OCT) has been recognized. We tested the feasibility of OCT measures of retinal asymmetry as a diagnostic test for multiple sclerosis at the community level. In this community-based study of 72 120 subjects, we examined the diagnostic potential of the inter-eye difference of inner retinal OCT data for multiple sclerosis using the UK Biobank data collected at 22 sites between 2007 and 2010. OCT reporting and quality control guidelines were followed. The inter-eye percentage difference (IEPD) and inter-eye absolute difference (IEAD) were calculated for the macular retinal nerve fibre layer (RNFL), ganglion cell inner plexiform layer (GCIPL) complex and ganglion cell complex. Area under the receiver operating characteristic curve (AUROC) comparisons were followed by univariate and multivariable comparisons accounting for a large range of diseases and co-morbidities. Cut-off levels were optimized by ROC and the Youden index. The prevalence of multiple sclerosis was 0.0023 [95% confidence interval (CI) 0.00229–0.00231]. Overall the discriminatory power of diagnosing multiple sclerosis with the IEPD AUROC curve (0.71, 95% CI 0.67–0.76) and IEAD (0.71, 95% CI 0.67–0.75) for the macular GCIPL complex were significantly higher if compared to the macular ganglion cell complex IEPD AUROC curve (0.64, 95% CI 0.59–0.69, P = 0.0017); IEAD AUROC curve (0.63, 95% CI 0.58–0.68, P 0.14) with narrow confidence intervals. In conclusion, the OCT macular GCIPL complex IEPD and IEAD may be considered as supportive measurements for multiple sclerosis diagnostic criteria in a young patient without relevant co-morbidity. The metric does not allow separation of multiple sclerosis from neuromyelitis optica. Retinal OCT imaging is accurate, rapid, non-invasive, widely available and may therefore help to reduce need for invasive and more costly procedures. To be viable, higher sensitivity and specificity levels are needed.

Published
2021
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96. Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images

Author

Currant, Hannah, Hysi, Pirro, Fitzgerald, Tomas W., Gharahkhani, Puya, Bonnemaijer, Pieter W.M., Senabouth, Anne, Hewitt, Alex W., Atan, Denize, Aung, Tin, Charng, Jason, Choquet, Hélène, Craig, Jamie, Khaw, Peng T., Klaver, Caroline C.W., Kubo, Michiaki, Ong, Jue Sheng, Pasquale, Louis R., Reisman, Charles A., Daniszewski, Maciej, Powell, Joseph E., Pébay, Alice, Simcoe, Mark J., Thiadens, Alberta A.H.J., van Duijn, Cornelia M., Yazar, Seyhan, Jorgenson, Eric, MacGregor, Stuart, Hammond, Chris J., Mackey, David A., Wiggs, Janey L., Foster, Paul J., Patel, Praveen J., Birney, Ewan, Khawaja, Anthony P., Currant, Hannah, Hysi, Pirro, Fitzgerald, Tomas W., Gharahkhani, Puya, Bonnemaijer, Pieter W.M., Senabouth, Anne, Hewitt, Alex W., Atan, Denize, Aung, Tin, Charng, Jason, Choquet, Hélène, Craig, Jamie, Khaw, Peng T., Klaver, Caroline C.W., Kubo, Michiaki, Ong, Jue Sheng, Pasquale, Louis R., Reisman, Charles A., Daniszewski, Maciej, Powell, Joseph E., Pébay, Alice, Simcoe, Mark J., Thiadens, Alberta A.H.J., van Duijn, Cornelia M., Yazar, Seyhan, Jorgenson, Eric, MacGregor, Stuart, Hammond, Chris J., Mackey, David A., Wiggs, Janey L., Foster, Paul J., Patel, Praveen J., Birney, Ewan, and Khawaja, Anthony P.

Abstract

Optical Coherence Tomography (OCT) enables non-invasive imaging of the retina and is used to diagnose and manage ophthalmic diseases including glaucoma. We present the first large-scale genome-wide association study of inner retinal morphology using phenotypes derived from OCT images of 31,434 UK Biobank participants. We identify 46 loci associated with thickness of the retinal nerve fibre layer or ganglion cell inner plexiform layer. Only one of these loci has been associated with glaucoma, and despite its clear role as a biomarker for the disease, Mendelian randomisation does not support inner retinal thickness being on the same genetic causal pathway as glaucoma. We extracted overall retinal thickness at the fovea, representative of foveal hypoplasia, with which three of the 46 SNPs were associated. We additionally associate these three loci with visual acuity. In contrast to the Mendelian causes of severe foveal hypoplasia, our results suggest a spectrum of foveal hypoplasia, in part genetically determined, with consequences on visual function.

Published
2021

98. Randomised controlled trial of screening and prophylactic treatment to prevent primary angle closure glaucoma

Author

Yip, Jennifer L.Y., Foster, Paul J., Uranchimeg, Davatseren, Javzandulam, Balt, Javzansuren, Dash, Munhzaya, Tsengenbayar, Lee, Pak S., Baassanhuu, Jamyanjav, Gilbert, Clare E., Khaw, Peng T., Johnson, Gordon J., and Nolan, Winifred P.

Subjects
Angle-closure glaucoma -- Prevention, Angle-closure glaucoma -- Research, Medical screening -- Research, Anterior chamber (Eye) -- Medical examination, Anterior chamber (Eye) -- Research, Health
Published
2010

99. Visual impairment, severe visual impairment, and blindness in children in Britain (BCVIS2): a national observational study

Author

Teoh, Lucinda J, primary, Solebo, Ameenat Lola, additional, Rahi, Jugnoo S, additional, Abbott, Joe, additional, Abdullah, Wajda, additional, Adams, Gill, additional, Allen, Louise, additional, Anderson, Christopher, additional, Ansell, Karen, additional, Anwar, Samira, additional, Ash, Isabel, additional, Ashworth, Jane, additional, Aslam, Sher, additional, Astagi, Majunath, additional, Ball, Colin, additional, Balu, Rajesh, additional, Barrett, Victoria, additional, Bassi, Zahabiyah, additional, Bates, Adam, additional, Batra, Dushyant, additional, Bell, Sarah, additional, Belmour, Linda, additional, Benzimra, James, additional, Birrell, Ginny, additional, Biswas, Susmito, additional, Blaikie, Andrew, additional, Blundell, Michael, additional, Bolton, Kate, additional, Bos, Ewoud, additional, Bowen, Pamela, additional, Bowman, Richard, additional, Boyle, Natalie, additional, Bradbury, John, additional, Bredow, Maria, additional, Bregu, Marsel, additional, Brennan, Nicholas, additional, Brennan, Rosie, additional, Brittain, Paul, additional, Buchanan, Charles, additional, Bunce, Catey, additional, Bunting, Howard, additional, Burgess, Priscilla, additional, Burke, Cathie, additional, Bush, Alexandra Kate, additional, Butcher, Jeremy, additional, Butler, Lucilla, additional, Cane, Clare, additional, Chadwick, Cathryn, additional, Charlton, Ruth, additional, Childs, Anne-Marie, additional, Choi, Jessy, additional, Choleva, Vivi, additional, Churchill, Amanda, additional, Clarke, Michael, additional, Clayton, Peter, additional, Clifford, Luke, additional, Connor, Alan, additional, Cox, Rachel, additional, Cresswell, Lyn, additional, Dahlmann-Noor, Annegret, additional, D'Amore, Angela, additional, Dattani, Mehul, additional, Dean, Fiona, additional, Devlin, Anita, additional, Dhir, Luna, additional, Doherty, Cora, additional, Dorey, Suzanne, additional, Drimmie, Fiona, additional, Duke, Tina, additional, Dutton, Gordon, additional, Eaton, Fiona, additional, Eaton, Megan, additional, Eckersley, Danielle, additional, Edelsten, Clive, additional, Elderkin, Rachel, additional, Ennis, Julia, additional, Escardo-Paton, Julia, additional, Estephen, Ziad, additional, Etuwewe, Onajite, additional, Evans, Anthony, additional, Ezekwe, Adjoa, additional, Fairfield, Jenny, additional, Falzon, Kevin, additional, Ferguson, Allison, additional, Fleck, Brian, additional, Gainsborough, Mary, additional, Galloway, Alexandra, additional, Gerson-Sofer, Naomi, additional, Gibbon, Caspar, additional, Gibson, Patricia, additional, Goss, Kevin, additional, Graham-Evans, Katherine, additional, Gray, Judith, additional, Gregory, Anna, additional, Gulati, Arun, additional, Gurtin-Zorkun, Deniz, additional, Guy, Emma, additional, Haddad, Diab, additional, Haggerty, Helen, additional, Haigh, Paul, additional, Hale, Julia, additional, Hamada, Samer, additional, Hancox, Joanne, additional, Hanna, Kerry, additional, Harris, Sian, additional, Harrison, Christine, additional, Harvey, Phillip, additional, Headland, Sophie, additional, Heath, Dominic, additional, Heaton, Paul, additional, Henderson, Robert, additional, Hingorani, Melanie, additional, Hirst, Zoe, additional, Hogg, Claire, additional, Hogler, Wolfgang, additional, Holden, Roger, additional, Hoole, Janice, additional, Horridge, Karen, additional, Howard, Delyth, additional, Howells, Rachel, additional, Irvine, Vanessa, additional, Irving, Clare, additional, Johnson, Nicola, additional, Johnston, Ian, additional, Jollands, Alice, additional, Jones, David, additional, Joseph, Annie, additional, Joshi, Archana, additional, Kandaswamy, Pugazhvendan, additional, Kattakayam, Charles, additional, Keenan, Joseph, additional, Kelly, Anne, additional, Kersey, James, additional, Khan, Awais, additional, Khaw, Peng, additional, Kipioti, Tina, additional, Kiran, Sadia, additional, Kneen, Lesley, additional, Kotagiri, Ajay, additional, Kulshrestha, Richa, additional, Lambley, Rosemary, additional, Lavy, Tim, additional, Lawson, Joanna, additional, Lee, Vicki, additional, Leitch, Jane, additional, Lennon, Julie, additional, Lipshen, Gabi, additional, Lloyd, Chris, additional, Loftus, John, additional, Lomas, Tom, additional, Long, Vernon, additional, Mackinnon, Jane, additional, MacRae, Mary, additional, Mahmood, Usman, additional, Maino, Anna, additional, Maling, Sarah, additional, Mansfield, David, additional, Marder, Elizabeth, additional, Markham, Richard, additional, Marr, Jane, additional, Marsh, Catherine, additional, Maw, Anna, additional, McCartney, Eleanor, additional, McCullagh, Helen, additional, McDonald, Anna, additional, McPhee, Derek, additional, Miall, Lawrence, additional, Mistry, Shila, additional, Moate, Benjamin, additional, Mohan, Meyyammai, additional, Moore, Helen, additional, Moore, Will, additional, Morgan, Nicola, additional, Morton, Claire, additional, Mulvihill, Alan, additional, Nair, Ranjit, additional, Newman, Bill, additional, Nitsch, Christiane, additional, O'Connell, Katy, additional, Oluonye, Ngozi, additional, Pai, Vittaldas, additional, Palmer, Helen, additional, Papadopoulos, Maria, additional, Parkinson, Shelagh, additional, Parmar, Bina, additional, Parulekar, Manoj, additional, Parvathareddy, Madhavi, additional, Patel, Dipesh, additional, Patel, Himanshu, additional, Patel, Kamal, additional, Pennefather, Philippa, additional, Petrone, Flaudia, additional, Pierrepoint, Marcus, additional, Pilling, Rachel, additional, Pollard, Sally, additional, Puertas, Renata, additional, Pysden, Karen, additional, Quinn, Anthony, additional, Quinn, Philip, additional, Rachdan, Diyaa, additional, Raina, Jyoti, additional, Rajak, Saul, additional, Ramm, Laura, additional, Rands, Catherine, additional, Rao, Tekki, additional, Ray, Mary, additional, Reddy, Ashwin, additional, Reilly, Sheilla, additional, Rekha, Maralla, additional, Richardson, Greg, additional, Riordan, Andrew, additional, Roberts, Nerys, additional, Robertson, Helen, additional, Robinson, Gillian, additional, Rogers, Neil, additional, Saeed, Shakir, additional, Salmon, Caroline, additional, Sargent, Jenefer, additional, Sarvananthan, Nagini, additional, Schmoll, Conrad, additional, Self, James, additional, Sellar, P, additional, Service, Elaine, additional, Shafiq, Ayad, additional, Shah, Shilpa, additional, Sharma, Vinod, additional, Sharp, Jemima, additional, Shaw, Julia, additional, Shenoy, Manjula, additional, Sleep, Tamsin, additional, Smit, Elisa, additional, Smyth, Katherine, additional, Speedwell, Lynne, additional, Spowart, Katherine, additional, Standring, P, additional, Stanga, Paulo, additional, Stanley, Alison, additional, Stanton, Alan, additional, Steel, David, additional, Stephen, John, additional, Stewart, Catherine, additional, Street, Jessica, additional, Stucke, Sally, additional, Sutherland, Shona, additional, Tambe, Katya, additional, Tandon, Anamika, additional, Tappin, Alison, additional, Taylor, Kate, additional, Taylor, Robert, additional, Teasdale, Katherine, additional, Theodorou, Maria, additional, Thomas, Gareth, additional, Thomas, Megan, additional, Thomas, Paula, additional, Thompson, Dorothy, additional, Thomson, Stephen, additional, Thopte, Indrajit, additional, Tiffin, Peter, additional, Tillett, Angela, additional, Traunecker, Heidi, additional, Tsimpida, Maria, additional, Van Someren, Vivienne, additional, Venkatesh, Udupa, additional, Vermaak, Zoe, additional, Vincent, Michael, additional, Walker, David, additional, Walker, Simon, additional, Walsh, Deidre, additional, Walters, Bronwyn, additional, Ward Platt, Martin, additional, Watson, Louise, additional, Watts, Patrick, additional, West, Siobhan, additional, West, Stephanie, additional, White, Cathy, additional, White, Joy, additional, Whitlingum, Gabriel, additional, Williams, Cathy, additional, Wilne, Sophie, additional, Wilson, Janice, additional, Wong, Chien, additional, Woodbridge, Tamsin, additional, Wright, Paul, additional, Wyles, Martha, additional, and Wylie, Philip, additional

Published
2021
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100. Ambient Air Pollution Associations with Retinal Morphology in the UK Biobank

Author

Chua, Sharon Y.L., Khawaja, Anthony P., Dick, Andrew D., Morgan, James, Dhillon, Baljean, Lotery, Andrew J., Strouthidis, Nicholas G., Reisman, Charles, Peto, Tunde, Khaw, Peng T., Foster, Paul J., Patel, Praveen J., Littlejohns, Thomas, Allen, Naomi, Beli, Eleni, Atan, Denize, Aslam, Tariq, Barman, Sarah A., Barrett, Jenny H., Bishop, Paul, Bunce, Catey, Carare, Roxana O., Chakravarthy, Usha, Chan, Michelle, Crabb, David P., Day, Alexander, Desai, Parul, Dhillon, Bal, Egan, Cathy, Ennis, Sarah, Fruttiger, Marcus, Gallacher, John E.J., Garway-Heath, David F., Gibson, Jane, Gore, Dan, Guggenheim, Jeremy A., Hammond, Chris J., Hardcastle, Alison, Harding, Simon P., Hogg, Ruth E., Hysi, Pirro, Keane, Pearse A., Lascaratos, Gerassimos, Macgillivray, Tom, Mackie, Sarah, McGaughey, Michelle, McGuinness, Bernadette, McKay, Gareth J., McKibbin, Martin, Moore, Tony, Morgan, James E., Muthy, Zaynah A., O’Sullivan, Eoin, Owen, Chris G., Paterson, Euan, Petzold, Axel, Rahi, Jugnoo S., Rudnikca, Alicja R., Self, Jay, Sivaprasad, Sobha, Steel, David, Stratton, Irene, Strouthidis, Nicholas, Sudlow, Cathie, Thomas, Dhanes, Trucco, Emanuele, Tufail, Adnan, Vitart, Veronique, Vernon, Stephen A., Viswanathan, Ananth C., Williams, Cathy, Williams, Katie, Woodside, Jayne V., Yates, Max M., and Zheng, Yalin

Subjects
Adult, Male, Retinal Ganglion Cells, medicine.medical_specialty, Retinal layers, air pollution, Air pollution, Nerve fiber layer, Glaucoma, Outer plexiform layer, Retinal Pigment Epithelium, Absorbance, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Nerve Fibers, Retinal Diseases, Ophthalmology, Surveys and Questionnaires, medicine, Humans, Outer nuclear layer, Aged, Biological Specimen Banks, Chemistry, Clinical and Epidemiologic Research, Retinal, retinal layers, Middle Aged, medicine.disease, GF, SDG 11 - Sustainable Cities and Communities, United Kingdom, medicine.anatomical_structure, Cross-Sectional Studies, OCT, Inner nuclear layer, 030221 ophthalmology & optometry, Female, Nitrogen Oxides, Particulate Matter, RE, sense organs, Layer (electronics), 030217 neurology & neurosurgery, Tomography, Optical Coherence, Photoreceptor Cells, Vertebrate
Abstract

PURPOSE. Because air pollution has been linked to glaucoma and AMD, we characterized the relationship between pollution and retinal structure. METHODS. We examined data from 51,710 UK Biobank participants aged 40 to 69 years old. Ambient air pollution measures included particulates and nitrogen oxides. SD-OCT imaging measured seven retinal layers: retinal nerve fiber layer, ganglion cell–inner plexiform layer, inner nuclear layer, outer plexiform layer + outer nuclear layer, photoreceptor inner segments, photoreceptor outer segments, and RPE. Multivariable regression was used to evaluate associations between pollutants (per interquartile range increase) and retinal thickness, adjusting for age, sex, race, Townsend deprivation index, body mass index, smoking status, and refractive error. RESULTS. Participants exposed to greater particulate matter with an aerodynamic diameter of CONCLUSIONS. Greater exposure to PM2.5, PM2.5 absorbance, and nitrogen oxides were all associated with apparently adverse retinal structural features.

Published
2020
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