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53. The burden of metabolic risk factors in North Africa and the Middle East, 1990–2019: findings from the Global Burden of Disease Study

Author

Malekpour, Mohammad-Reza, Abbasi-Kangevari, Mohsen, Ghamari, Seyyed-Hadi, Khanali, Javad, Heidari-Foroozan, Mahsa, Moghaddam, Sahar Saeedi, Azangou-Khyavy, Mohammadreza, Rezazadeh-Khadem, Sahba, Rezaei, Negar, Shobeiri, Parnian, Esfahani, Zahra, Rezaei, Nazila, Aali, Amirali, Abd-Elsalam, Sherief, Abdoun, Meriem, Absalan, Abdorrahim, Abu-Gharbieh, Eman, Abu-Rmeileh, Niveen ME., Abu-Zaid, Ahmed, Ahmadi, Ali, Ahmadi, Sepideh, Ahmed, Ayman, Rashid, Tarik Ahmed, Ajami, Marjan, Akbarzadeh-Khiavi, Mostafa, Al Hamad, Hanadi, Alalwan, Tariq A., Alhabib, Khalid F., Alimohamadi, Yousef, Alipour, Vahid, Aljunid, Syed Mohamed, Alomari, Mahmoud A., Alqahatni, Saleh A., Al-Raddadi, Rajaa M., Aminian Dehkordi, Javad Javad, Amir-Behghadami, Mehrdad, Amiri, Sohrab, Anvari, Davood, Arabloo, Jalal, Arulappan, Judie, Arumugam, Ashokan, Aryan, Zahra, Athar, Mohammad, Athari, Seyyed Shamsadin, Avan, Abolfazl, Azadnajafabad, Sina, Azari, Samad, Azizi, Hosein, Baghcheghi, Nayereh, Bagheri, Nader, Bagherieh, Sara, Baltatu, Ovidiu Constantin, Bhagavathula, Akshaya Srikanth, Bhojaraja, Vijayalakshmi S., Bouaoud, Souad, Butt, Muhammad Hammad, Campos, Luciana Aparecida, Chitheer, Abdulaal, Cheshmeh Soltani, Reza Darvishi, Darwesh, Aso Mohammad, Djalalinia, Shirin, Dodangeh, Milad, El Sayed Zaki, Maysaa, Elbarazi, Iffat, Elhadi, Muhammed, El-Huneidi, Waseem, Ezzeddini, Rana, Fareed, Mohammad, Farrokhpour, Hossein, Fatehizadeh, Ali, Galali, Yaseen, Ghaderi, Amir, Ghafourifard, Mansour, Nour, Mohammad Ghasemi, Ghashghaee, Ahmad, Gholamalizadeh, Maryam, Goleij, Pouya, Golitaleb, Mohamad, Habibzadeh, Parham, Hafezi-Nejad, Nima, Halwani, Rabih, Hasani, Hamidreza, Hashemian, Maryam, Hassan, Amr, Hassanipour, Soheil, Hassankhani, Hadi, Hezam, Kamal, Homayounfar, Reza, Hosseini, Seyed Kianoosh, Hosseini, Kaveh, Hosseinzadeh, Mehdi, Hoveidamanesh, Soodabeh, Jaafari, Jalil, Jahrami, Haitham, Jamshidi, Elham, Javaheri, Tahereh, Jayapal, Sathish Kumar, Kabir, Ali, Karimi, Amirali, Kaydi, Neda, Keykhaei, Mohammad, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khan, Moien A.B., Khan, Kashif Ullah, Khan, Yusra H., Khatatbeh, Moawiah Mohammad, Kompani, Farzad, Koohestani, Hamid Reza, Kuddus, Mohammed, Lasrado, Savita, Lee, Sang-woong, Mahjoub, Soleiman, Mahmoodpoor, Ata, Mahmoudi, Elham, Rad, Elaheh Malakan, Malih, Narges, Malik, Ahmad Azam, Mallhi, Tauqeer Hussain, Manla, Yosef, Mansouri, Borhan, Mansournia, Mohammad Ali, Mardi, Parham, Marjani, Abdoljalal, Masoudi, Sahar, Nasab, Entezar Mehrabi, Menezes, Ritesh G., Mevsim, Vildan, Mohammad, Yousef, Mohammadi, Mokhtar, Mohammadi, Esmaeil, Mohammadifard, Noushin, Mohammed, Arif, Momtazmanesh, Sara, Montazeri, Fateme, Moradi, Maryam, Moradi-Lakeh, Maziar, Morovatdar, Negar, Murray, Christopher J.L., Natto, Zuhair S., Nejadghaderi, Seyed Aria, Nowroozi, Ali, Oladnabi, Morteza, Bali, Ahmed Omar, Omer, Emad, Toroudi, Hamidreza Pazoki, Pezzani, Raffaele, Langroudi, Ashkan Pourabhari, Rafiei, Sima, Rahimi, Mehran, Rahimi-Movaghar, Vafa, Rahmani, Shayan, Rahmani, Amir Masoud, Rahmanian, Vahid, Rao, Chythra R., Rashedi, Sina, Rashidi, Mohammad-Mahdi, Rawassizadeh, Reza, Mohamed Redwan, Elrashdy Moustafa, Rezaee, Malihe, Rezaei, Maryam, Riahi, Seyed Mohammad, Roshandel, Gholamreza, Saad, Aly, Saber-Ayad, Maha Mohamed, Sabour, Siamak, Sabzmakan, Leila, Saddik, Basema, Sadeghi, Erfan, Sadeghian, Saeid, Sahebkar, Amirhossein, Saki, Morteza, Salahi, Saina, Salahi, Sarvenaz, Farrokhi, Amir Salek, Salem, Marwa Rashad, Salimzadeh, Hamideh, Samy, Abdallah M., Sarrafzadegan, Nizal, Sathian, Brijesh, Shafeghat, Melika, Shah, Syed Mahboob, Shah, Jaffer, Shahbandi, Ataollah, Shahraki-Sanavi, Fariba, Shams-Beyranvand, Mehran, Shanawaz, Mohd, Sharafi, Kiomars, Sharifi-Rad, Javad, Shetty, Jeevan K., Varniab, Zahra Shokri, Shorofi, Seyed Afshin, Siabani, Soraya, Soltani-Zangbar, Mohammad Sadegh, Tabaeian, Seidamir Pasha, Tabatabaeizadeh, Seyed-Amir, Tabish, Mohammad, Taheri, Majid, Abkenar, Yasaman Taheri, Soodejani, Moslem Taheri, Taherkhani, Amir, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Tigabu, Bereket M., Vakilian, Alireza, Vaziri, Siavash, Vo, Bay, Yazdanpanah, Fereshteh, Yigit, Arzu, Yiğit, Vahit, Zahir, Mazyar, Zaman, Burhan Abdullah, Zamanian, Maryam, Zangiabadian, Moein, Zare, Iman, Zareshahrabadi, Zahra, Mokdad, Ali H., Naghavi, Mohsen, Larijani, Bagher, and Farzadfar, Farshad

Published
2023
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55. Report of the first seven agents in the I-SPY COVID trial: a phase 2, open label, adaptive platform randomised controlled trial

Author

Files, D. Clark, Aggarwal, Neil, Albertson, Timothy, Auld, Sara, Beitler, Jeremy R., Berger, Paul, Burnham, Ellen L., Calfee, Carolyn S., Cobb, Nathan, Crippa, Alessio, Discacciati, Andrea, Eklund, Martin, Esserman, Laura, Friedman, Eliot, Gandotra, Sheetal, Khan, Kashif, Koff, Jonathan, Kumar, Santhi, Liu, Kathleen D., Martin, Thomas R., Matthay, Michael A., Meyer, Nuala J., Obermiller, Timothy, Robinson, Philip, Russell, Derek, Thomas, Karl, Wong, Se Fum, Wunderink, Richard G., Wurfel, Mark M., Yen, Albert, Youssef, Fady A., Darmanian, Anita, Dzierba, Amy L., Garcia, Ivan, Gosek, Katarzyna, Madahar, Purnema, Mittel, Aaron M., Muir, Justin, Rosen, Amanda, Schicchi, John, Serra, Alexis L., Wahab, Romina, Gibbs, Kevin W., Landreth, Leigha, LaRose, Mary, Parks, Lisa, Wynn, Adina, Ittner, Caroline A.G., Mangalmurti, Nilman S., Reilly, John P., Harris, Donna, Methukupally, Abhishek, Patel, Siddharth, Boerger, Lindsie, Kazianis, John, Higgins, Carrie, McKeehan, Jeff, Daniel, Brian, Fields, Scott, Hurst-Hopf, James, Jauregui, Alejandra, Brown Swigart, Lamorna, Blevins, Daniel, Nguyen, Catherine, Suarez, Alexis, Tanios, Maged A., Sarafian, Farjad, Shah, Usman, Adelman, Max, Creel-Bulos, Christina, Detelich, Joshua, Harris, Gavin, Nugent, Katherine, Spainhour, Christina, Yang, Philip, Haczku, Angela, Hardy, Erin, Harper, Richart, Morrissey, Brian, Sandrock, Christian, Budinger, G. R. Scott, Donnelly, Helen K., Singer, Benjamin D., Moskowitz, Ari, Coleman, Melissa, Levitt, Joseph, Lu, Ruixiao, Henderson, Paul, Asare, Adam, Dunn, Imogene, and Botello Barragan, Alejandro

Published
2023
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64. Constructing Hard Examples for Graph Isomorphism

Author

Dawar, Anuj and Khan, Kashif

Subjects
Computer Science - Computational Complexity, Computer Science - Discrete Mathematics, F.2.2, G.2.2, G.4
Abstract

We describe a method for generating graphs that provide difficult examples for practical Graph Isomorphism testers. We first give the theoretical construction, showing that we can have a family of graphs without any non-trivial automorphisms which also have high Weisfeiler-Leman dimension. The construction is based on properties of random 3XOR-formulas. We describe how to convert such a formula into a graph which has the desired properties with high probability. We validate the method by an experimental implementation. We construct random formulas and validate them with a SAT solver to filter through suitable ones, and then convert them into graphs. Experimental results demonstrate that the resulting graphs do provide hard examples that match the hardest known benchmarks for graph isomorphism., Comment: 20 pages. A revised version incorporating new experimental results

Published
2018

66. New mechanistic insights on Justicia vahlii Roth: UPLC-Q-TOF-MS and GC–MS based metabolomics, in-vivo, in-silico toxicological, antioxidant based anti-inflammatory and enzyme inhibition evaluation

Author

Basit, Abdul, Ahmad, Saeed, ur Rehman Khan, Kashif, Sherif, Asmaa E., Aati, Hanan Y., Ovatlarnporn, Chitchamai, Abbas Khan, Mohsin, Rao, Huma, Ahmad, Imtiaz, Nadeem Shahzad, Muhammad, Ahmad Ghalloo, Bilal, Shah, Hassan, Khan, Kifayat Ullah, and Dilshad, Rizwana

Published
2022
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68. Trend in Clinical Trial Participation During COVID-19: A Secondary Analysis of the I-SPY COVID Clinical Trial

Author

Yang, Philip, Dickert, Neal W., Haczku, Angela, Spainhour, Christine, Auld, Sara C., Aggarwal, Neil R., Albertson, Timothy, Auld, Sara, Beitler, Jeremy R., Berger, Paul, Burnham, Ellen L., Calfee, Carolyn S., Cobb, Nathan, Crippa, Alessio, Discacciati, Andrea, Eklund, Martin, Esserman, Laura, Files, D. Clark, Friedman, Eliot, Gandotra, Sheetal, Khan, Kashif, Koff, Jonathan, Kumar, Santhi, Liu, Kathleen D., Martin, Thomas R., Matthay, Michael A., Meyer, Nuala J., Obermiller, Timothy, Robinson, Philip, Russell, Derek, Thomas, Karl, Wong, Se Fum, Wunderink, Richard G., Wurfel, Mark M., Yen, Albert, Youssef, Fady A., Darmanian, Anita, Dzierba, Amy L., Garcia, Ivan, Gosek, Katarzyna, Madahar, Purnema, Mittel, Aaron M., Muir, Justin, Roden, Amanda, Schicchi, John, Serra, Alexis L., Wahab, Romina, Gibbs, Kevin W., Landreth, Leigha, LaRose, Mary, Parks, Lisa, Wynn, Adina, Ittner, Caroline A. G., Mangalmurti, Nilam S., Reilly, John P., Harris, Donna, Methukupally, Abhishek, Patel, Siddharth, Boerger, Lindsie, Kazianis, John, Higgins, Carrie, McKeehan, Jeff, Daniel, Brian, Fields, Scott, Hurst-Hopf, James, Jauregui, Alejandra, Swigart, Lamorna Brown, Belvins, Daniel, Nguyen, Catherine, Suarez, Alexis, Tanios, Maged A., Sarafian, Farjad, Shah, Usman, Adelman, Max, Creel-Bulos, Christina, Detelich, Joshua, Harris, Gavin, Nugent, Katherine, Spainhour, Christine, Yang, Philip, Haczku, Angela, Hardy, Erin, Harper, Richart, Morrissey, Brian, Sandrock, Christian, Budinger, G. R. Scott, Donnelly, Helen K., Singer, Benjamin D., Moskowitz, Ari, Coleman, Melissa, Levitt, Joseph, Lu, Ruixiao, Henderson, Paul, Asare, Adam, Dunn, Imogene, and Barragan, Alejandro Botello

Published
2023
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78. Numerical simulation on the MHD time-dependent Williamson nanofluid flow with cross diffusion and heat generation/absorption over a stretching plate.

Author

Ullah, Muhammad Asad, Khan, Kashif Ali, Hussein, Mohamed, Fathima, Dowlath, Alroobaea, Roobaea, Raza, Nauman, Ghazwani, Hassan Ali, and Awan, Aziz Ullah

Subjects
*NANOFLUIDS, *PHOTOTHERMAL effect, *MAGNETOHYDRODYNAMICS, *ORDINARY differential equations, *PARTIAL differential equations, *MASS transfer, *THERMAL engineering
Abstract

This novel study unfolds the heat and mass transfer investigation of Williamson nanofluid (WNF) through a porous medium past a stretching plate, along with considering heat generation/absorption. Nanoparticles hold significant significance in thermal engineering, industrial operations, and biomedical advancements, contributing to enhanced heat transfer, cooling mechanisms, thermal extrusion processes, and applications in cancer treatment, particularly in addressing brain tumors. The coupled ordinary differential equations (ODEs) are gained from governing partial differential equations (PDEs) by applying sufficient transformations. Then the ODEs of a nonlinear nature, along with boundary conditions, are solved through bvp4c, a built-in MATLAB program. A good agreement has been found in comparing the present study with already published papers. Numerical values for skin friction, mass transfer, and heat transfer are shown through a table against involved physical parameters, especially for both injection (S < 0) and suction (S > 0) cases, by varying the values of unsteadiness parameter A and Weissenberg number W e . The effects of the physical parameters on velocity, temperature, and mass profile are graphically depicted and illustrated minutely. It is noted that both the magnetic and Williamson parameters cause the thickness of the boundary layer to be reduced. It can be deduced from these findings that the rate of heat transfer over the surface of the plate decreases as the unsteadiness parameter increases. Furthermore, it is observed that an increase in the parameters of thermophoresis and Brownian motion leads to a higher temperature of the nanofluid. [ABSTRACT FROM AUTHOR]

Published
2024
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79. Evaluating the Reparative Potential of Secretome from Patient-Derived Induced Pluripotent Stem Cells during Ischemia–Reperfusion Injury in Human Cardiomyocytes.

Author

Rody, Elise, Zwaig, Jeremy, Derish, Ida, Khan, Kashif, Kachurina, Nadezda, Gendron, Natalie, Giannetti, Nadia, Schwertani, Adel, and Cecere, Renzo

Subjects
INDUCED pluripotent stem cells, PLURIPOTENT stem cells, SERUM-free culture media, INTRACELLULAR calcium, STEM cells
Abstract

During a heart attack, ischemia causes losses of billions of cells; this is especially concerning given the minimal regenerative capability of cardiomyocytes (CMs). Heart remuscularization utilizing stem cells has improved cardiac outcomes despite little cell engraftment, thereby shifting focus to cell-free therapies. Consequently, we chose induced pluripotent stem cells (iPSCs) given their pluripotent nature, efficacy in previous studies, and easy obtainability from minimally invasive techniques. Nonetheless, using iPSC secretome-based therapies for treating injured CMs in a clinical setting is ill-understood. We hypothesized that the iPSC secretome, regardless of donor health, would improve cardiovascular outcomes in the CM model of ischemia–reperfusion (IR) injury. Episomal-generated iPSCs from healthy and dilated cardiomyopathy (DCM) donors, passaged 6–10 times, underwent 24 h incubation in serum-free media. Protein content of the secretome was analyzed by mass spectroscopy and used to treat AC16 immortalized CMs during 5 h reperfusion following 24 h of hypoxia. IPSC-derived secretome content, independent of donor health status, had elevated expression of proteins involved in cell survival pathways. In IR conditions, iPSC-derived secretome increased cell survival as measured by metabolic activity (p < 0.05), cell viability (p < 0.001), and maladaptive cellular remodelling (p = 0.052). Healthy donor-derived secretome contained increased expression of proteins related to calcium contractility compared to DCM donors. Congruently, only healthy donor-derived secretomes improved CM intracellular calcium concentrations (p < 0.01). Heretofore, secretome studies mainly investigated differences relating to cell type rather than donor health. Our work suggests that healthy donors provide more efficacious iPSC-derived secretome compared to DCM donors in the context of IR injury in human CMs. These findings illustrate that the regenerative potential of the iPSC secretome varies due to donor-specific differences. [ABSTRACT FROM AUTHOR]

Published
2024
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80. Comparative effects of organic and inorganic amendments on heavy metal co‐contaminated soil remediation, reducing heavy metal bioavailability and enhancing nutrient accessibility for maize growth.

Author

Akbar, Zulqarnain, Akbar, Waqas Ali, Irfan, Muhammad, Rahim, Hafeez Ur, Khan, Usama, Saleem, Atif, Ali, Shamsher, and Khan, Kashif

Subjects
ELECTRIC conductivity of soils, SOIL amendments, CALCAREOUS soils, HEAVY metals, LEAD
Abstract

Many years ago, widespread and ineffective technologies led to significant ecological contamination, primarily due to heavy metals (HMs), particularly lead (Pb) and cadmium (Cd). Plant growth in heavy metals contaminated and calcareous soil is a challenge for all the growers worldwide. Several organic and inorganic amendments are used by researchers in different types of soils. However, their impact on soil contaminated with toxic metals and alkaline in reaction is still unclear. Therefore, the current pot experiment investigates the relative effect of organic (wheat straw biochar and farmyard manure) at 10 and 20 t ha−1 and inorganic (diammonium phosphate and gypsum) at 100 and 150 kg ha−1 amendments on NPK availability, soil organic matter, soil properties, and maize growth under Cd and Pb stress. Highest soil pH (7.61), soil electrical conductivity (0.25 dS m−1), soil organic matter (1.40%), plant height (92 cm), shoot dry weight (41 g), and root dry weight (5.5 g) were observed because of biochar application at 20 t ha−1. While the highest total nitrogen (N) (0.13%), and phosphorus (P) (8.16 mg kg−1) were recorded with diammonium phosphate application at 150 kg ha−1, moreover, application of farmyard manure at 20 t ha−1 increased the soil potassium (K) (108.14 mg kg−1). Biochar application at 20 t ha−1 greatly reduced the toxic metals bioavailability with a high immobilization index, that is, Cd (52%) and Pb (43.79%) lead to lower concentrations of metals in roots and shoots as well. A negative correlation was identified between soil pH, soil organic matter, and soil Cd, Pb, demonstrating the positive impact of biochar in terms of the reduction of toxic metals by enhancing pH and soil organic matter, found to be the most effective amendment for soil improvement and plant growth under Cd and Pb stress condition. [ABSTRACT FROM AUTHOR]

Published
2024
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81. A Comparative Analysis of the Gas Pipeline Geopolitics of China and India in the Central Asia Republics.

Author

Khan, Kashif Hasan, Omidi, Ali, and Alkan, Abdulmelik

Subjects
*NATURAL gas pipelines, *GEOPOLITICS
Abstract

After the discovery of large oil and gas deposits in Central Asia, the region has become a vital battlefield for major world powers' competing interests, resulting in a complex geopolitical and energy transportation interaction known as 'pipeline politics'. After independence, multinational energy companies and global powers contacted the Central Asian Republics. Chinese investment has dominated the region's energy sector throughout the past decade. India is strategically seeking Central Asia's energy resources as it becomes more global. This article compares China's and India's Central Asian natural gas strategy and identifies research shortcomings. The complex geopolitical landscape is considered while examining their objectives and regional investments. This analysis reveals these methods' motivations and their effects on the Central Asian Republics and the world. China has an advantage over India in Central Asian pipeline politics, making the region vital to China's energy security. [ABSTRACT FROM AUTHOR]

Published
2024
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82. Evolutionary Safe Padé Approximation Scheme for Dynamical Study of Nonlinear Cervical Human Papilloma Virus Infection Model.

Author

Ali, Javaid, Ciancio, Armando, Khan, Kashif Ali, Raza, Nauman, Baskonus, Haci Mehmet, Luqman, Muhammad, and Khan, Zafar-Ullah

Subjects
HUMAN papillomavirus, FINITE differences, GENETIC algorithms, CERVICAL cancer, MATHEMATICAL functions
Abstract

This study proposes a structure-preserving evolutionary framework to find a semi-analytical approximate solution for a nonlinear cervical cancer epidemic (CCE) model. The underlying CCE model lacks a closed-form exact solution. Numerical solutions obtained through traditional finite difference schemes do not ensure the preservation of the model's necessary properties, such as positivity, boundedness, and feasibility. Therefore, the development of structure-preserving semi-analytical approaches is always necessary. This research introduces an intelligently supervised computational paradigm to solve the underlying CCE model's physical properties by formulating an equivalent unconstrained optimization problem. Singularity-free safe Padé rational functions approximate the mathematical shape of state variables, while the model's physical requirements are treated as problem constraints. The primary model of the governing differential equations is imposed to minimize the error between approximate solutions. An evolutionary algorithm, the Genetic Algorithm with Multi-Parent Crossover (GA-MPC), executes the optimization task. The resulting method is the Evolutionary Safe Padé Approximation (ESPA) scheme. The proof of unconditional convergence of the ESPA scheme on the CCE model is supported by numerical simulations. The performance of the ESPA scheme on the CCE model is thoroughly investigated by considering various orders of non-singular Padé approximants. [ABSTRACT FROM AUTHOR]

Published
2024
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91. Health-related quality of life among people with diabetes: A cross-sectional study in Hail region, Saudi Arabia ​

Author

Alshammari, Farhan, primary, Ansari, Mukhtar, additional, Khan, Kashif Ullah, additional, Neupane, Dinesh, additional, Hussain, Arshad, additional, Anwar, Sirajudheen, additional, Alshammari, Bushra, additional, Alrasheeday, Awatif, additional, Jamshed, Shazia, additional, Sapkota, Binaya, additional, and Rasheed, Abdur, additional

Published
2024
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100. Computational approach and flow analysis of chemically reactive tangent hyperbolic nanofluid over a cone and plate.

Author

Seadawy, Aly, Raza, Nauman, Khalil, O. H., Khan, Kashif Ali, and Usman, M.

Subjects
NATURAL heat convection, NANOFLUIDS, CONES, DRAG coefficient, DRAG (Aerodynamics), FREE convection
Abstract

A new study aims to clarify the analytical and mathematical dimensions of the tangent hyperbolic fluid through the plate and cone with useful uses in technical devices like the handling of biomass pyrolysis and viscometer. The presence of chemical process and mixed convection in the natural characteristics of liquid is taken into account. By implementing the homotopy analysis approach, the achieved coupling system is inspected. The influence of the flow control variables on the related profiles is evaluated quantitatively and qualitatively in order to get a full understanding of the current pagination. Through the deep study, it is calculated that convective thermal and surface drag factor for the plate is greater in magnitude than for the cone. The superiority is also observed for the plate in the thermal field relative to that in the cone. The results shows that the heat transfer improves as Hartmann number (M) and Brownian motion factor (Nt) increase but it decreases with an increase of thermophoresis factor (Nb). Also it can be found that effect of drag coefficient is more pronounced or higher for cone as compared to plate. [ABSTRACT FROM AUTHOR]

Published
2024
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