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DFT and TD-DFT studies of B3LYP/6–31 g(d,p) with the D2 version of Grimme’s dispersion are used to examine the adsorption of a CH2O molecule on Be12O12 and MBe12O12 nano-cages (M = K, Mn, or Cu atom). The energy gap for Be12O12 was 8.210 eV, while the M encapsulation decreased its value to 0.685–1.568 eV, whereas the adsorption of the CH2O gas decreased the Eg values for Be12O12 and CuBe12O12 to 4.983 and 0.876 eV and increased its values for KBe12O12 and MnBe12O12 to 1.286 and 1.516 eV, respectively. The M encapsulation enhanced the chemical adsorption of CH2O gas with the surface of Be12O12. The UV-vis spectrum of the Be12O12 nano-cage was dramatically affected by the M encapsulation as well as the adsorption of the CH2O gas. In addition, the adsorption energies and the electrical sensitivity of the Be12O12 as well as the MBe12O12 nano-cages to CH2O gas could be manipulated with an external electric field. Our results may be fruitful for utilizing Be12O12 as well as MBe12O12 nano-cages as candidate materials for removing and sensing formaldehyde gas.

The design of the chef’s uniform requires a set of conditions and standards. The chef’s uniform is considered one of the functional outfits that requires the designer to study the conditions and nature of work and the risks to which the chef is exposed, such as direct fire, as he uses it in the maturation of foods, and many types of hot liquids to boiling point and the risks involved. The chef is also exposed to the use of different types of sharp knives.Also, taking into account the chef’s exposure to constant heat throughout the work period, due to the nature and conditions of his work taking into account the protection of the human body from high heat, humidity, radiation, insects, chemicals and intense friction. Applying this to the chef’s clothes and costumes, for example, making ventilation holes or making supports for strengthening in places Movement, making an adjustment in the pattern that facilitates movement, taking into account the treatment of large and abnormal sizes in the design. Which reflects the addition of proposals for innovative designs using modern fabrics, high-quality technologies, new proposed colors and modern fashion requirements.

The current research aims to: 1- Build an entrepreneurial trend in the halls of fitness and bodybuilding in the city of Mosul from the viewpoint of its visitors. 2- Investigate the level of leadership in the halls of fitness and body building in the city of Mosul from the viewpoint of its Visitors. The researchers used the descriptive approach in its survey to suit the nature of the research, and the research community included (378) people who went to the halls of fitness and body building in the city of Mosul, which were numbered (70) halls distributed on the right sides of the city with (10) halls, and the left with (60) Halls, thus, the research sample included (27) halls for fitness and body building in the city of Mosul, which represented (38.57%) of the research community, and these halls are divided into (9) halls on the right side and (18) halls on the left side of the city of Mosul. The number of people returning to these halls according to the scientific conditions of stability was (378) people distributed over the pilot sample with (18) people and the building sample with (260) people and (68.78%) from the research sample in addition to (100) people for the sample application. And by (26.45%) of the research sample, With regard to the research tools, the researcher built a scale of pioneering orientation for fitness halls and bodybuilding in the city of Mosul according to four dimensions (creativity, risk-taking, proactive, and competitive). On the final research sample in order to obtain data that were statistically treated through the percentage, the arithmetic mean, the simple correlation coefficient, and (T) test for two independent samples. The study concluded the following conclusions: - the level of entrepreneurship in the halls of fitness and bodybuilding in the city of Mosul ranged from medium to weak. The researchers recommended the following: 1- The departments of the halls of fitness and bodybuilding must adopt the pioneering approach in order to achieve the success for these halls. 2- The necessity for hall administrations to develop them by updating the devices and tools used as well as the other aspects in the hall.

Abstract Liver cancer is considered one of the deadliest diseases with one of the highest disease burdens worldwide. Among the different types of liver cancer, hepatocellular carcinoma is considered to be the most common type. Multiple conventional approaches are being used in treating hepatocellular carcinoma. Focusing on drug treatment, regular agents in conventional forms fail to achieve the intended clinical outcomes. In order to improve the treatment outcomes, utilizing nanoparticles—specifically lipid based nanoparticles—are considered to be one of the most promising approaches being set in motion. Multiple forms of lipid based nanoparticles exist including liposomes, solid lipid nanoparticles, nanostructured lipid carriers, microemulsion, nanoemulsion, phytosomes, lipid coated nanoparticles, and nanoassemblies. Multiple approaches are used to enhance the tumor uptake as well tumor specificity such as intratumoral injection, passive targeting, active targeting, and stimuli responsive nanoparticles. In this review, the effect of utilizing lipidic nanoparticles is being discussed as well as the different tumor uptake enhancement techniques used. Graphical Abstract

In this study, biosynthesized nanoparticles using chitosan, Ulva fasciata, and Avicennia marina leaves extracts (A, B, and C, respectively), were evaluated as paint additives to control marine fouling on different substrates. These biocidal nanoparticle compounds were prepared using a green biosynthesis method. Their characterizations were conducted using Fourier-Transform Infrared spectroscopy and Transmission electron microscopy. Each nanoparticle compound was mixed with a prepared paint, resulting in three formulations for each (e.g. 1C, 2C, 3C), containing 20%, 40%, and 60% by weight. Painted PVC, wood, and steel with these nine paints, and the control were immersed in seawater for different periods. After two months of immersion, the least number of fouling species, (one species) was recorded on both the wood and steel panels that were coated with paint (1C). Meanwhile, after four months, the least numbers of fouling (four and six species) were recorded on wood and steel panels that were coated with paint (3C). After around seven months of immersion, the least numbers of fouling species (five and ten) were recorded on wood and steel panels that were coated with paints (1C and 3C), respectively. The steel panel coated with (3C), harbored ∼2% of the total number of barnacles found on the control, after 7 months of immersion. The superior antifouling agent efficiency of extract (C) nanoparticles can be attributed to its constituents of polyphenols, ammonium compounds, and high concentrations of alcohols, besides the presence of both aromatic and aliphatic amide and amide derivatives.

Summary: Background: Primary Ovarian Insufficiency (POI), a public health problem, affects 1-3.7% of women under 40 yielding infertility and a shorter lifespan. Most causes are unknown. Recently, genetic causes were identified, mostly in single families. We studied an unprecedented large cohort of POI to unravel its molecular pathophysiology. Methods: 375 patients with 70 families were studied using targeted (88 genes) or whole exome sequencing with pathogenic/likely-pathogenic variant selection. Mitomycin-induced chromosome breakages were studied in patients’ lymphocytes if necessary. Findings: A high-yield of 29.3% supports a clinical genetic diagnosis of POI. In addition, we found strong evidence of pathogenicity for nine genes not previously related to a Mendelian phenotype or POI: ELAVL2, NLRP11, CENPE, SPATA33, CCDC150, CCDC185, including DNA repair genes: C17orf53(HROB), HELQ, SWI5 yielding high chromosomal fragility. We confirmed the causal role of BRCA2, FANCM, BNC1, ERCC6, MSH4, BMPR1A, BMPR1B, BMPR2, ESR2, CAV1, SPIDR, RCBTB1 and ATG7 previously reported in isolated patients/families. In 8.5% of cases, POI is the only symptom of a multi-organ genetic disease. New pathways were identified: NF-kB, post-translational regulation, and mitophagy (mitochondrial autophagy), providing future therapeutic targets. Three new genes have been shown to affect the age of natural menopause supporting a genetic link. Interpretation: We have developed high-performance genetic diagnostic of POI, dissecting the molecular pathogenesis of POI and enabling personalized medicine to i) prevent/cure comorbidities for tumour/cancer susceptibility genes that could affect life-expectancy (37.4% of cases), or for genetically-revealed syndromic POI (8.5% of cases), ii) predict residual ovarian reserve (60.5% of cases). Genetic diagnosis could help to identify patients who may benefit from the promising in vitro activation-IVA technique in the near future, greatly improving its success in treating infertility. Funding: Université Paris Saclay, Agence Nationale de Biomédecine.

Introduction: In the present research, the health benefits of the traditional Egyptian food called Kishk Sa′eedi (KS) and KS mixed with gum Arabic (GA) or with a mixture of GA and pomegranate seed oil (PSO) were studied in a rat model of metabolic syndrome (MS) induced by feeding high fructose high hydrogenated fat diet (HFFD). Methods: Rats were divided into a normal control group (NC) fed on a balanced diet (Diet 1), a MS control (MSC) receiving HFFD (Diet 2), and three test groups feeding on HFFD containing KS (Diet 3), KS with GA (Diet 4), and KS with GA and PSO (Diet 5), respectively for five weeks. Biochemical and histopathological changes were assessed. Results: Significant increase in blood glucose, plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST), urea, creatinine, uric acid, malondialdehyde (MDA), dyslipidemia and reduction in reduced glutathione (GSH) were demonstrated in MSC compared to NC (P < 0.05). Significant elevation in liver fat, MDA and gene expression of interleukin-6 (IL-6) with significant down-regulation of peroxisome proliferator-activated receptor (PPAR-α) were noticed in MSC compared to NC (P < 0.05). The three test diets improved plasma high-density lipoprotein-cholesterol (HDL-C), uric acid, MDA, liver PPAR-α and IL-6 expression (P < 0.05) compared to MSC without affecting liver lipids. Blood glucose, plasma dyslipidemia, AST, creatinine and urea were improved by diet 3 and diet 5 (P < 0.05). Diet 3 elevated GSH and reduced ALT and MDA (P < 0.05). Histopathological changes induced by HFFD in both liver and kidney showed variable improvement by feeding the tested diets. Conclusion: The tested diets significantly improved MS rat model with superiority to diet 3.

Abstract Background The nature of opaque lesions such as effusions, atelectasis, masses, and consolidations can be clarified by sonography. This study investigated the sensitivity and accuracy of ultrasound-guided percutaneous core needle biopsy in different thoracic tumors (lung, pleural, chest wall, and mediastinal). Results Sixty patients underwent ultrasound-guided percutaneous transthoracic core biopsy of peripheral thoracic masses with a Tru-Cut needle with a big bore. Twenty masses were in the lung, seventeen lesions were in the pleura, ten masses were in the mediastinum, eleven were enlarged palpable lymph nodes, and two masses were in chest wall. The sensitivity, PPV, and accuracy for detection of chest tumors in the chest wall, mediastinum, lung, and pleura were 100% for all, and in LN 88.9, 100, and 90.9%, respectively. The overall diagnostic performance of sonar-guided Tru-Cut needle biopsy in diagnosis was 97.78% sensitivity, 98.18% accuracy, and 100% PPV. Conclusion Tru-Cut needle percutaneous transthoracic core biopsy is a convenient and sensitive process in obtaining samples under ultrasound guidance for exact histological diagnosis of thoracic tumors. The diagnostic efficiency is high, and the technique can also be used in outpatients, which is relatively simple. Trial registration NCT, NCT04741958 Registered 5 February 2021, retrospectively registered,

The morphology of coastal regions is continually changing because of both natural and human factors. Monitoring and understanding these changes are essential for efficient coastal management and sustainable development. To protect and develop beaches, quantitative monitoring of coastal changes is crucial. According to this study, there is a persistent erosion issue with the shoreline of the Rosetta region in Egypt. Over the previous century, there has been noticeable erosion. This is mostly because of the Aswan High Dam, which was built in 1964 and decreased runoff and sediment flow. Five Landsat images spanning the years 1980–2023 were utilized in this study. The Nile Delta would be eroding at an alarming rate if action were not taken due to coastal erosion, which is made worse by sea level rise. Our study's primary goal is to evaluate the shoreline of the Rosetta region and identify rates of erosion and accretion as well as patterns of accumulation and erosion using a combination of statistical analysis of the coastline using DSAS software and remote sensing techniques. It also seeks to pinpoint hotspots that require security. In this study, the Shoreline Linear Regression Rate (LRR), End Point Rate (EPR), Shoreline Change Envelope (SCE), and Net Shoreline Movement (NSM) were determined by creating crosssections perpendicular to the baseline using the Digital Shoreline Analysis System (DSAS). According to the analysis of coastal change, the periods with the highest levels of erosion were between 1980 and 1990, before the protection of the promontory took place. In addition, the results extracted from this study showed a stabilized shoreline between 2000 and 2023 at the Rosetta Promontory and noticeable erosion in the east and west of the promontory. [ABSTRACT FROM AUTHOR]

This study employs density functional theory (DFT) calculations at the B3LYP/6-311+g(d,p) level to investigate the interaction of XH3 gases (X = N, P, As) with the Mn-phthalocyanine molecule (MnPc). Grimme's D3 dispersion correction is applied to consider long-range interactions. The adsorption behavior is explored under the influence of an external static electric field (EF) ranging from −0.514 to 0.514 V/Å. Chemical adsorption of XH3 molecules onto the MnPc molecule is confirmed. The adsorption results in a significant decrease in the energy gap (Eg) of MnPc, indicating the potential alteration of its optical properties. Quantum theory of atoms in molecules (QTAIM) analysis reveals partially covalent bonds between XH3 and MnPc, and the charge density differenc (Δρ) calculations suggest a charge donation-back donation mechanism. The UV-vis spectrum of MnPc experiences a blue shift upon XH3 adsorption, highlighting MnPc's potential as a naked-eye sensor for XH3 molecules. Thermodynamic calculations indicate exothermic interactions, with NH3/MnPc being the most stable complex. The stability of NH3/MnPc decreases with increasing temperature. The direction and magnitude of the applied electric field (EF) play a crucial role in determining the adsorption energy (Eads) for XH3/MnPc complexes. The Eg values decrease with an increasing negative EF, which suggests that the electrical conductivity (σ) and the electrical sensitivity (ΔEg) of the XH3/MnPc complexes are influenced by the magnitude and direction of the applied EF. Overall, this study provides valuable insights into the suggested promising prospects for the utilization of MnPc in sensing applications of XH3 gases. [ABSTRACT FROM AUTHOR]

The recovery and recycling/upcycling of plastics and polymer-based materials is needed in order to reduce plastic waste accumulated over decades. Mechanical recycling processes have made a great contribution to the circularity of plastic materials, contributing to 99% of recycled thermoplastics. Challenges facing this family of processes limit its outreach to 30% of plastic waste. Complementary pathways are needed to increase recycling rates. Chemical processes have the advantage of decomposing plastics into a variety of hydrocarbons that can cover a wide range of applications, such as monomers, lubricants, phase change materials, solvents, BTX (benzene, toluene, xylene), etc. The aim of the present work is to shed light on different chemical recycling pathways, with a special focus on thermochemicals. The study will cover the effects of feedstock, operating conditions, and processes used on the final products. Then, it will attempt to correlate these final products to some petrochemical feedstock being used today on a large scale. [ABSTRACT FROM AUTHOR]

Background Weaning failure is common in mechanically ventilated patients, and if ultrasound can predict weaning outcome remains controversial. The purpose of this study was to evaluate the diaphragmatic function (thickness and excursion) measured by ultrasound as a predictor of the extubation outcome. Methods We included 62 mechanically ventilated patients from the chest intensive care unit in this study. Sixty-two patients who successfully passed the spontaneous breathing trial (SBT) were enrolled. The transthoracic ultrasound of the diaphragm was performed during an SBT to the assess diaphragmatic function (excursion and thickness), and they were classified into the successful extubation group and the failed extubation group. Results There was a statistically significant increase in the successful extubation group in the diaphragmatic excursion and thickness fraction (p

Abstract Background Convex probe endobronchial ultrasound is a minimally invasive technique used for performing real-time transbronchial needle aspiration of enlarged hilar and mediastinal lymph nodes and could be used for diagnosing proximal peribronchial lesions. Although computed tomography, magnetic resonant imaging, and positron emission tomography/computed tomography have relatively high sensitivity for mediastinal evaluation, pathology is the gold standard. This study compared between Echo Tip Ultra HD-EBUS 22G needle and Echo Tip ProCore HD-EBUS 22G needle in diagnosis of mediastinal lesions using convex probe endobronchial ultrasound. Results Twenty-four patients with mediastinal lesions were included. Convex probe endobronchial ultrasound-guided transbronchial needle aspiration using both Echo Tip Ultra HD 22G and Echo Tip ProCore HD 22G needles was done to all patients with no peripheral lymph node enlargement. CP-EBUS TBNA had diagnostic accuracy 50%, sensitivity 47.6%, and specificity 100% in diagnosis of mediastinal lesions. The Echo Tip Ultra HD needle had diagnostic accuracy 40.9%, sensitivity 38%, and specificity 100% compared to the Echo Tip ProCore HD needle which had diagnostic accuracy 31.8%, sensitivity 82.5%, and specificity 100%. The difference between both needles was statistically insignificant. The Echo Tip Ultra 22G HD needle had more representative cellularity (82%) compared to the Echo Tip ProCore 22G HD needle (45%) with a significant difference between both needles (p value = 0.001). Conclusion Both needles can be used equally in sampling mediastinal lesions. This study supports that Echo Tip Ultra HD and Echo Tip ProCore HD needles can be used equally in sampling of mediastinal lesions and supports ultrasound screening of enlarged supraclavicular and cervical lymph nodes before performing EBUS-TBNA in patients with mediastinal lesions.

The orbital error is one of the errors in GPS which affect the accuracy of GPS positioning. In this research GPS broadcast, ultra-rapid, rapid and precise satellite ephemerides are used for processing different baseline lengths among some CORS stations by using the Trimble Business Center software (TBC) and different satellite ephemerides (NRCan ultra-rapid, NRCan rapid and IGS final) are tested in CSRS-PPP online application at the same CORS stations. In this research, when using TBC software for processing the different baseline lengths by using the different satellite ephemerides and compared the coordinates of CORS stations which obtained from the different satellite ephemerides with each other. The results showed that the best satellite ephemerides closest to rapid and final satellite ephemerides are the ultra-rapid (00 UTC) and ultra-rapid (06 UTC). When processing the same CORS stations which used at TBC on CSRSPPP online application by using the different satellite ephemerides it is found also that the NRCan ultra-rapid closest to final satellite ephemerides.