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51. Help seeking behavior and onset-to-alarm time in patients with acute stroke: substudy of the preventive antibiotics in stroke study.

Author

Zock, E., Kerkhoff, H., Kleyweg, R. P., van Bavel-Ta, T. B. V., Scott, S., Kruyt, N. D., Nederkoorn, P. J., and van de Beek, D.

Subjects
*STROKE prevention, *ANTIBIOTICS, *HELP-seeking behavior, *SYMPTOMS, *MEDICAL care
Abstract

Background: Patients with acute stroke often do not seek immediate medical help, which is assumed to be driven by lack of knowledge of stroke symptoms. We explored the process of help seeking behavior in patients with acute stroke, evaluating knowledge about stroke symptoms, socio-demographic and clinical characteristics, and onset-to-alarm time (OAT). Methods: In a sub-study of the Preventive Antibiotics in Stroke Study (PASS), 161 acute stroke patients were prospectively included in 3 Dutch hospitals. A semi-structured questionnaire was used to assess knowledge, recognition and interpretation of stroke symptoms. With in-depth interviews, response actions and reasons were explored. OAT was recorded and associations with socio-demographic, clinical parameters were assessed. Results: Knowledge about stroke symptoms does not always result in correct recognition of own stroke symptoms, neither into correct interpretation of the situation and subsequent action. In our study population of 161 patients with acute stroke, median OAT was 30 min (interquartile range [IQR] 10-150 min). Recognition of one-sided weakness and/ or sensory loss (p = 0.046) and adequate interpretation of the stroke situation (p = 0.003), stroke at daytime (p = 0.002), severe stroke (p = 0.003), calling the emergency telephone number (p = 0.004), and transport by ambulance (p = 0.040) were associated with shorter OAT. Conclusion: Help seeking behavior after acute stroke is a complex process. A shorter OAT after stroke is associated with correct recognition of one-sided weakness and/or sensory loss, adequate interpretation of the stroke situation by the patient and stroke characteristics and logistics of stroke care, but not by knowledge of stroke symptoms. [ABSTRACT FROM AUTHOR]

Published
2016
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52. Built-in test of electrode degradation of multi-electrode array biosensors

Author

Liu, H., Dumas, N., Richardson, A., Heal, R., Kerkhoff, H. G., Liu, H., Dumas, N., Richardson, A., Heal, R., and Kerkhoff, H. G.

Abstract

Micro-electrode array (MEA) is a widely used platform in biosensor systems, which provide a technology in communicating with micro chemical and biological world. This paper addresses hte topic of testing micro electrode degradation for MEAs, which is a common encountered damage during its application. The basic logic of the proposed test method is examining the symmetrical impedance of the included surrounding electrode by a central stimulating electrode. The feasability was proved by preliminary simulation and the underlaying assumption was confirmed by application experience.

Published
2006

53. Delay-fault ATPG for high-speed electrically erasable PLDs

Author

Kerkhoff, H., Sachdev, M., and Klaasen, C.

Abstract

A dedicated timing model has been developed for an electrically erasable PLD. The programming part, including the electrically erasable transistors, has received special attention. This timing model has been primarily developed to be used as an input for a test-pattern generator for combinational and sequential implementations especially dedicated for detecting and diagnosing small delay faults in high-speed applications.

Published
1996

54. VHDL-AMS fault simulation for testing DNA bio-sensing arrays

Author

Kerkhoff, H G, Zhang, X, Liu, H, Richardson, A, Nouet, P, Azais, F, Kerkhoff, H G, Zhang, X, Liu, H, Richardson, A, Nouet, P, and Azais, F

Abstract

the market of microelectronic fluidic arrays for biomedical applications, like DNA determination, is rapidly increasing. In order to evaluate these systems in terms of required Design-for-Test structures, fault simulations in both fluidic and electronic domains are necessary. VHDL-AMS can be used successfully in this case. This paper shows a highly testable architecture of a DNA Bio-Sensing array, its basic sensing concept, fluidic modeling and sensitivity analysis. The overall VHDL-AMS fault simulation of the system is presented.

Published
2005

55. Design and Test of an Oscillation-based System Architecture for DNA Sensor Arrays

Author

Liu, H., Kerkhoff, H. G., Richardson, A., Zhang, X., Nouet, P., Azais, F., Liu, H., Kerkhoff, H. G., Richardson, A., Zhang, X., Nouet, P., and Azais, F.

Abstract

A DfT strategy for MEMS-based DNA sensors is investigated in this paper. Based on a fault-free and defect model developed for a single sensing element and the VHDL-AMS simulation results, it is implied that an oscillation-based interface might be a potential solution for both testing and read out of this DNA sensor array system. A possible physical implementation of the biosensing array is proposed based on some important boundary conditions. Finally, a potential architecture of the read out electronics to implement the strategy for the array is proposed.

Published
2005

56. Adjunctive dexamethasone in adults with meningococcal meningitis

Author

Heckenberg, Sebastiaan G.B., primary, Brouwer, Matthijs C., additional, van der Ende, Arie, additional, van de Beek, Diederik, additional, Wennekes, MJ, additional, Esselink, RAJ, additional, de Graaf, RJ, additional, ten Houten, R, additional, Baart, JC, additional, Keunen, RWM, additional, Oerlemans, WGH, additional, Broere, D, additional, Straathof, CSM, additional, Verheul, GAM, additional, van de Vlasakker, CJW, additional, Enting, RH, additional, van Schaik, IN, additional, van der Plas, JPL, additional, Bienfait, HP, additional, Christiaans, MH, additional, Hoogerwaard, EM, additional, Reijneveld, JC, additional, Alting van Geusau, RB, additional, Berendes, JN, additional, Jacobs, BC, additional, van den Berg, JSP, additional, Witteveen, RJW, additional, Stevens, M, additional, Herderschee, D, additional, Struys, MA, additional, Jansen, C, additional, Anten, HWM, additional, Brekelmans, GFJ, additional, Fennis, TFM, additional, Prick, JJW, additional, Pop, PHM, additional, Wouda, EJ, additional, Bülens, C, additional, Lohman, HJMM, additional, Blankevoort, JP, additional, Visee, HF, additional, Smits, RCF, additional, Berntsen, PJIM, additional, Saxena, R, additional, Geelen, JAG, additional, Schiphof, PR, additional, Weisfelt, M, additional, Grosveld, WJHM, additional, van Zuilen, EV, additional, Kwa, IH, additional, van Domburg, PHMF, additional, Medaer, RHJ, additional, Koppenaal, A, additional, van der Kamp, W, additional, Holscher, RS, additional, Schipper, JP, additional, van Dijk, GW, additional, Kerkhoff, H, additional, Taphoorn, MJB, additional, Huisman, UW, additional, Kok, AJM, additional, van Spreeken, A, additional, Admiraal, P, additional, de Jong, PJ, additional, van Lieshout, HBM, additional, Zorgdrager, AN, additional, Gijsbers, CJ, additional, de Steen, Avan, additional, van Raak, EPM, additional, Gerrits, M, additional, Wieringa, EJ, additional, Leenders, EM, additional, Roebroek, RMJA, additional, Snoek, JW, additional, Vermeij, AJ, additional, Wessels, PH, additional, Boon, AM, additional, Vrooland, L, additional, Knibbeler, JGM, additional, ter Spill, HW, additional, Meijer, RJ, additional, Krooman, JP, additional, Heerema, J, additional, Oonk, JGW, additional, Molenaar, DSM, additional, Koeman, JP, additional, Hoefnagels, W, additional, Duyff, RF, additional, Don, JA, additional, Keuter, EJV, additional, Dunnewold, RJW, additional, Beintema, KD, additional, Zegerius, L, additional, Mauser, HW, additional, and Bollen, AE, additional

Published
2012
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65. Defect oriented test development based on inductive fault analysis

Author

Richardson, Andrew, Kerkhoff, H G, Harvey, Russell, Richardson, Andrew, Kerkhoff, H G, and Harvey, Russell

Abstract

This paper describes a method of developing a Defect Oriented Test (DOT) strategy by using Inductive Fault Analysis (IFA) and layout dependent fault models extracted from process defect statistics. The results of a quantitative prediction of the effectiveness of several test strategies, such as functional, IDDQ, and a low voltage power supply method, on a current-mode Digital to Analogue Converter are discussed and show that no single test method is superior.

Published
1995

67. Multifocal inflammatory demyelinating neuropathy

Author

Van den Berg-Vos, R.M., primary, Van den Berg, L.H., additional, Franssen, H., additional, Vermeulen, M., additional, Witkamp, T.D., additional, Jansen, G.H., additional, van Es, H.W., additional, Kerkhoff, H., additional, and Wokke, J.H. J., additional

Published
2000
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70. Sarcoglycanopathies in Dutch patients with autosomal recessive limb girdle muscular dystrophy

Author

Ginjaar, H.B., primary, vd Kooi, A., additional, Ceelie, H., additional, Kneppers, A.L.J., additional, Barth, P.G., additional, Busch, H.F.M., additional, Wokke, J.H.J., additional, Kerkhoff, H., additional, Broere, D., additional, Anderson, L.V.B., additional, Bönnemann, C.G., additional, Jeanpierre, M., additional, Bakker, E., additional, de Visser, M., additional, and v Ommen, G.J.B., additional

Published
1997
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83. Radiative decay and autoionization in the D-states of the 3 d4 s5 s configuration in CuI.

Author

Kerkhoff, H., Micali, G., Werner, K., Wolf, A., and Zimmermann, P.

Abstract

The CuI 3 d4 s5 s D-states, which lie above the ionization limit, were populated by stepwise collisional and laser excitation. With respect to their total angular momentum, the D-states have completely different decay modes. Whereas the lifetimes τ( D)=8.2(4)·10s and τ( D)=7.9(6)·10 s are determinrd by radiative transitions and were measured by time-resolved spectroscopy, the lifetimes τ( D)=1.59(6)·10s and τ( D)=1.28(5)·10s are due to autoionization and were deduced from the widths of the excitation signals observed by ion detection. [ABSTRACT FROM AUTHOR]

Published
1981
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87. Radiative decay and autoionization in the4D-states of the 3d94s5s configuration in CuI

Author

Kerkhoff, H., Micali, G., Werner, K., Wolf, A., and Zimmermann, P.

Abstract

The CuI 3d94s5s4D-states, which lie above the ionization limit, were populated by stepwise collisional and laser excitation. With respect to their total angular momentum, the4D-states have completely different decay modes. Whereas the lifetimest(4D7/2)=8.2(4)·10-9s andt(4D1/2)=7.9(6)·10-9 s are determinrd by radiative transitions and were measured by time-resolved spectroscopy, the lifetimest(4D5/2)=1.59(6)·10-12s andt(4D3/2)=1.28(5)·10-12s are due to autoionization and were deduced from the widths of the excitation signals observed by ion detection.

Published
1981
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89. Analysis of Input and Output Configurations for Use in Four-Valued CCD Programmable Logic Arrays

Author

NAVAL POSTGRADUATE SCHOOL MONTEREY CA DEPT OF ELECTRICAL AND COMPUTER ENGINEERING, Butler, J T, Kerkhoff, H G, NAVAL POSTGRADUATE SCHOOL MONTEREY CA DEPT OF ELECTRICAL AND COMPUTER ENGINEERING, Butler, J T, and Kerkhoff, H G

Abstract

As in binary, a multiple-valued programmable logic array (PLA) realises a sum-of-products expression specified by the user. However, in multiple-valued logic, there are many more operations than in binary, and an important question is the choice of operations which provides the greatest number of functions for a given chip area. In this paper, we analyse various PLA configurations using operations realised in the peristaltic multiple-valued CCD technology. We compare a multiple-valued CCD PLA implementation with four other proposed designs and show that there is a significant difference in chip area required to realise the same set of functions. The basis of comparison is the set of 4-valued unary functions., Published in the Journal of IEEE Proceedings, v134 n4 pt. E p168-176, July 1987.

Published
1987

90. A Fault-Tolerant MEF Peptide Synthesizer using Control and Direct Sensing Electrodes Employing Current and Impedance Tests

Author

Zhang, X., Kerkhoff, H. G., Mailly, F., Nouet, P., Liu, H., andrew richardson, CTIT - Testable Design & Test of Integrated Systems, Conception et Test de Systèmes MICroélectroniques (SysMIC), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre for Microsystems Engineering, Lancaster University, and Peridier, Martine

Subjects
[SPI.NANO] Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, ComputingMilieux_MISCELLANEOUS
Abstract

The research in the area of microelectronic fluidic (MEF) devices for biomedical applications is rapidly growing. As faults in these devices can have severe personal implications, a system is presented which includes fault-tolerance with respect to the systhesized biomaterials (peptides). It can employ purity detection of peptides via current tests of control electrodes of impedance measurements using direct sensing electrodes near the peptide collector area. In the case of purity problems, the location is marked, and repeated synthesis at another collector side is initiated.

91. Built-in test of electrode degradation of multi-electrode array biosensors

Author

Liu, H., Dumas, N., andrew richardson, Heal, R., and Kerkhoff, H. G.

Subjects
Hardware_GENERAL
Abstract

Micro-electrode array (MEA) is a widely used platform in biosensor systems, which provide a technology in communicating with micro chemical and biological world. This paper addresses hte topic of testing micro electrode degradation for MEAs, which is a common encountered damage during its application. The basic logic of the proposed test method is examining the symmetrical impedance of the included surrounding electrode by a central stimulating electrode. The feasability was proved by preliminary simulation and the underlaying assumption was confirmed by application experience.

92. Design and Test of an Oscillation-based System Architecture for DNA Sensor Arrays

Author

Liu, H., Kerkhoff, H. G., andrew richardson, Zhang, X., Nouet, P., and Azais, F.

Subjects
EC Grant Agreement nr.: FP6/507255
Abstract

A DfT strategy for MEMS-based DNA sensors is investigated in this paper. Based on a fault-free and defect model developed for a single sensing element and the VHDL-AMS simulation results, it is implied that an oscillation-based interface might be a potential solution for both testing and read out of this DNA sensor array system. A possible physical implementation of the biosensing array is proposed based on some important boundary conditions. Finally, a potential architecture of the read out electronics to implement the strategy for the array is proposed.

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