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2,669 results on '"Kehlet, Henrik"'

55. Multimodal prehabilitation to improve the clinical outcomes of frail elderly patients with gastric cancer: a study protocol for a multicentre randomised controlled trial (GISSG+2201)

Author

Sun, Yuqi, primary, Tian, Yulong, additional, Cao, Shougen, additional, Li, Leping, additional, Yu, Wenbin, additional, Ding, Yinlu, additional, Wang, Xixun, additional, Kong, Ying, additional, Wang, Xinjian, additional, Wang, Hao, additional, Hui, Xizeng, additional, Qu, Jianjun, additional, Wang, HongBo, additional, Duan, Quanhong, additional, Yang, Daogui, additional, Zhang, Huanhu, additional, Zhou, Shaofei, additional, Liu, Xiaodong, additional, Li, Zequn, additional, Meng, Cheng, additional, Kehlet, Henrik, additional, and Zhou, Yanbing, additional

Published
2023
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62. Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: infection and sepsis

Author

Myles, Paul, Gan, Tang Joon, Kurz, Andrea, Peyton, Phil, Sessler, Dan, Tramèr, Martin, Cyna, Alan, De Oliveira, Gildasio S., Jr., Wu, Christopher, Jensen, Mark, Kehlet, Henrik, Botti, Mari, Boney, Oliver, Haller, Guy, Grocott, Mike, Cook, Tim, Fleisher, Lee, Neuman, Mark, Story, David, Gruen, Russell, Bampoe, Sam, Evered, Lis, Scott, David, Silbert, Brendan, van Dijk, Diederik, Kalkman, Cor, Chan, Matthew, Grocott, Hilary, Eckenhoff, Rod, Rasmussen, Lars, Eriksson, Lars, Beattie, Scott, Wijeysundera, Duminda, Landoni, Giovanni, Leslie, Kate, Biccard, Bruce, Howell, Simon, Nagele, Peter, Richards, Toby, Lamy, Andre, Lalu, Manoj, Pearse, Rupert, Mythen, Monty, Canet, Jaume, Moller, Ann, Gin, Tony, Schultz, Marcus, Pelosi, Paolo, Gabreu, Marcelo, Futier, Emmanuel, Creagh-Brown, Ben, Fowler, Alexander, Abbott, Tom, Klein, Andy, Corcoran, Tomas, Cooper, David James, Dieleman, Stefan, Diouf, Elisabeth, McIlroy, David, Bellomo, Rinaldo, Shaw, Andrew, Prowle, John, Karkouti, Keyvan, Billings, Josh, Mazer, David, Jayarajah, Mohindas, Murphy, Michael, Bartoszko, Justyna, Sneyd, Rob, Morris, Steve, George, Ron, Moonesinghe, Ramani, Shulman, Mark, Lane-Fall, Meghan, Nilsson, Ulrica, Stevenson, Nathalie, Cooper, Jamie (DJ), van Klei, Wilton, Cabrini, Luca, Miller, Tim, Pace, Nathan, Jackson, Sandy, Buggy, Donal, Short, Tim, Riedel, Bernhard, Gottumukkala, Vijay, Alkhaffaf, Bilal, Johnson, Mark, Barnes, Jonathan, Hunter, Jennifer, Harris, Steve, Shankar-Hari, Manu, Jammer, Ib, Klein, Andrew A., Grocott, Michael P.W., and Mythen, Michael G.

Published
2019
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65. Spinal anaesthesia versus general anaesthesia (SAGA) on recovery after hip and knee arthroplasty: A study protocol for three randomized, single‐blinded, multi‐centre, clinical trials.

Author

Jensen, Christian Bredgaard, Gromov, Kirill, Foss, Nicolai Bang, Kehlet, Henrik, Pleckaitiene, Lina, Varnum, Claus, and Troelsen, Anders

Subjects
TOTAL hip replacement, CLINICAL trials, ANESTHESIA, RESEARCH protocols, POSTOPERATIVE pain, ANALGESIA
Abstract

Mobilisation difficulties, due to muscle weakness, and urinary retention are common reasons for prolonged admission following hip and knee arthroplasty procedures. Whether spinal anaesthesia is detrimental to early mobilisation is controversial. Previous studies have reported differences in post‐operative recovery between spinal anaesthesia and general anaesthesia; however, up‐to‐date comparisons in fast‐track setups are needed. Our randomized, single‐blinded, multi‐centre, clinical trials aim to compare the post‐operative recovery after total hip (THA), total knee (TKA), and unicompartmental knee arthroplasties (UKA) respectively when using either spinal anaesthesia (SA) or general anaesthesia (GA) in a fast‐track setup. Included patients (74 THA, 74 TKA, and 74 UKA patients) are randomized (1:1) to receive either SA (2 mL 0.5% Bupivacaine) or GA (Induction: Propofol 1.0–2.0 mg/kg iv with Remifentanil 3–5 mcg/kg iv. Infusion: Propofol 3–5 mg/kg/h and Remifentanil 0.5 mcg/kg/min iv). Patients undergo standard primary unilateral hip and knee arthroplasty procedures in an optimized fast‐track setup with intraoperative local infiltrative analgesia in TKA and UKA, post‐operative multimodal opioid sparing analgesia, immediate mobilisation with full weightbearing, no drains and in‐hospital only thromboprophylaxis. Data will be collected on the day of surgery and until patients are discharged. The primary outcome is the ability to be safely mobilised during a 5‐m walking test within 6 h of surgery. Secondary outcomes include fulfilment of discharge criteria, post‐operative pain, dizziness, and nausea as well as patient reported recovery and opioid related side effects. Data will also be gathered on all hospital contacts within 30‐days of surgery. This study will offer insights into advantages and disadvantages of anaesthetic methods used in fast‐track arthroplasty surgery. [ABSTRACT FROM AUTHOR]

Published
2024
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67. Update of the European Society of Anaesthesiology and Intensive Care Medicine evidence-based and consensus-based guideline on postoperative delirium in adult patients

Author

Aldecoa, César, primary, Bettelli, Gabriella, additional, Bilotta, Federico, additional, Sanders, Robert D., additional, Aceto, Paola, additional, Audisio, Riccardo, additional, Cherubini, Antonio, additional, Cunningham, Colm, additional, Dabrowski, Wojciech, additional, Forookhi, Ali, additional, Gitti, Nicola, additional, Immonen, Kaisa, additional, Kehlet, Henrik, additional, Koch, Susanne, additional, Kotfis, Katarzyna, additional, Latronico, Nicola, additional, MacLullich, Alasdair M.J., additional, Mevorach, Lior, additional, Mueller, Anika, additional, Neuner, Bruno, additional, Piva, Simone, additional, Radtke, Finn, additional, Blaser, Annika Reintam, additional, Renzi, Stefania, additional, Romagnoli, Stefano, additional, Schubert, Maria, additional, Slooter, Arjen J.C., additional, Tommasino, Concezione, additional, Vasiljewa, Lisa, additional, Weiss, Bjoern, additional, Yuerek, Fatima, additional, and Spies, Claudia D., additional

Published
2023
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77. Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations

Author

Gewandter, Jennifer S., Dworkin, Robert H., Turk, Dennis C., Farrar, John T., Fillingim, Roger B., Gilron, Ian, Markman, John D., Oaklander, Anne Louise, Polydefkis, Michael J., Raja, Srinivasa N., Robinson, James P., Woolf, Clifford J., Ziegler, Dan, Ashburn, Michael A., Burke, Laurie B., Cowan, Penney, George, Steven Z., Goli, Veeraindar, Graff, Ole X., Iyengar, Smriti, Jay, Gary W., Katz, Joel, Kehlet, Henrik, Kitt, Rachel A., Kopecky, Ernest A., Malamut, Richard, McDermott, Michael P., Palmer, Pamela, Rappaport, Bob A., Rauschkolb, Christine, Steigerwald, Ilona, Tobias, Jeffrey, and Walco, Gary A.

Published
2021
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88. Is smaller necessarily better? A systematic review comparing the effects of minilaparoscopic and conventional laparoscopic cholecystectomy on patient outcomes

Author

McCloy, Rory, Randall, Delia, Schug, Stephan, Kehlet, Henrik, Simanski, Christian, Bonnet, Francis, Camu, Frederic, Fischer, Barrie, Joshi, Girish, Rawal, Narinder, and Neugebauer, Edmund

Abstract

Abstract: Background: In recent years, minilaparoscopic cholecystectomy (MLC; total size of trocar incision <25 mm) has been increasingly advocated for the removal of the gallbladder, due to potentially better surgical outcomes (e.g., better cosmetic result, reduced pain, shorter hospital stay, quicker return to activity), but an evidence-based approach has been lacking. The current systematic review was undertaken to evaluate the importance of total size of trocar incision in improving surgical outcomes in adult laparoscopic cholecystectomy (LC). Methods: The literature was systematically reviewed using MEDLINE and EmBASE. Only randomized controlled trials in English, investigating minilaparoscopic versus conventional LC (total size of trocar incision ≥25 mm) and reporting pain scores were included. Quantitative analyses (meta-analyses) were performed on postoperative pain scores and other patient outcomes from more than one study where feasible and appropriate. Qualitative analyses consisted of assessing the number of studies showing a significant difference between the techniques. Results: Thirteen trials met the inclusion criteria. There was a trend towards reduced pain with MLC compared with conventional LC, without reduction in opioid use. Patients in the MLC group had slightly reduced length of hospital stay, but there were no significant differences for return to activity. The two interventions were also similar in terms of operating times and adverse events, but MLC was associated with better cosmetic result (largely patient rated). There was a significantly greater likelihood of conversion to conventional LC or to open cholecystectomy in the MLC group than there was of conversion to open cholecystectomy in the conventional LC group [OR 4.71 (95% confidence interval 2.67–8.31), p < 0.00001]. Conclusions: The data included in this review suggest that reducing the size of trocar incision results in some limited improvements in surgical outcomes after LC. However, it carries a higher risk of conversion to conventional LC or open cholecystectomy.

Published
2024
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90. Author Correction: Preferential inhibition of adaptive immune system dynamics by glucocorticoids in patients after acute surgical trauma

Author

Ganio, Edward A., Stanley, Natalie, Lindberg-Larsen, Viktoria, Einhaus, Jakob, Tsai, Amy S., Verdonk, Franck, Culos, Anthony, Ghaemi, Sajjad, Rumer, Kristen K., Stelzer, Ina A., Gaudilliere, Dyani, Tsai, Eileen, Fallahzadeh, Ramin, Choisy, Benjamin, Kehlet, Henrik, Aghaeepour, Nima, Angst, Martin S., and Gaudilliere, Brice

Published
2020
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92. Effects of perioperative enhanced recovery after surgery pathway management versus traditional management on the clinical outcomes of laparoscopic-assisted radical resection of distal gastric cancer: study protocol for a randomized controlled trial

Author

Tian, Yulong, Cao, Shougen, Li, Leping, He, Qingsi, Xia, Lijian, Jiang, Lixin, Ding, Yinlu, Wang, Xinjian, Wang, Hao, Mao, Weizheng, Hui, Xizeng, Shi, Yiran, Zhang, Huanhu, Chu, Xianqun, Kehlet, Henrik, and Zhou, Yanbing

Published
2020
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93. Preliminary effect and feasibility of physiotherapy with strength training and protein-rich nutritional supplement in combination with anabolic steroids in cross-continuum rehabilitation of patients with hip fracture: protocol for a blinded randomized controlled pilot trial (HIP-SAP1 trial)

Author

Hulsbæk, Signe, Ban, Ilija, Aasvang, Tobias Kvanner, Jensen, Jens-Erik Beck, Kehlet, Henrik, Foss, Nicolai Bang, Bandholm, Thomas, and Kristensen, Morten Tange

Published
2019
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94. Psychological predictors of acute postoperative pain after total knee and hip arthroplasty: A systematic review.

Author

Springborg, Anders H., Visby, Lasse, Kehlet, Henrik, and Foss, Nicolai B.

Subjects
TOTAL hip replacement, TOTAL knee replacement, POSTOPERATIVE pain, PAIN catastrophizing, PSYCHOLOGICAL factors
Abstract

Background: Identifying patients at high risk of acute postoperative pain after total knee or hip arthroplasty (TKA/THA) will facilitate individualized pain management and research on the efficacy of treatment options. Numerous studies have reported that psychological patient factors may influence acute postoperative pain, but most reviews have focused on chronic pain and functional outcomes. This systematic review aims to evaluate which psychological metrics are associated with acute postoperative pain after TKA and THA. Methods: A systematic search was conducted using the databases PubMed, EMBASE, Web of Science, and Cochrane Library until June 2022. Full‐text articles reporting associations of preoperative psychological factors with acute pain within 48 h of TKA or THA surgery were identified. Quality was assessed using the Quality in Prognostic Studies tool. Results: Eighteen studies containing 16 unique study populations were included. TKA was the most common procedure, and anxiety and depression were the most evaluated psychological metrics. Several different anesthetic techniques and analgesic regimens were used. The studies were generally rated as having a low to moderate risk of bias. Catastrophizing was associated with acute pain in six studies (of nine), mainly after TKA. In contrast, three studies (of 13) and two studies (of 13) found anxiety and depression, respectively, to be associated with acute postoperative pain. Conclusion: Pain catastrophizing seemed to be the most consistent psychological predictor of acute postoperative pain after TKA. The results for other psychological factors and THA were inconsistent. However, the interpretation of results was limited by considerable methodological heterogeneity. [ABSTRACT FROM AUTHOR]

Published
2023
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98. Gastrointestinal complications after fast-track total hip and knee replacement:an observational study in a consecutive 36,932 patient cohort

Author

Daugberg, Louise O. H., Kehlet, Henrik, Petersen, Pelle B., Jakobsen, Thomas, and Jørgensen, Christoffer C.

Subjects
THA, GI-bleed, POI, TKA, Fast-track, C. difficile, GI-complications
Abstract

IntroductionGastrointestinal complications after total hip (THA) and knee arthroplasty (TKA) have been reported to be between 0.3 and 2.6% with bleeding and C. difficile infection in 0–1%, and 0.1–1.7%, respectively. The use of enhanced recovery or “fast-track” protocols have focused on optimizing all aspects of perioperative care resulting in reduced length of hospital stay (LOS) and potentially also gastrointestinal complications. This study is a detailed analysis on the occurrence of postoperative gastrointestinal complications resulting in increased hospital stay or readmissions in a large consecutive cohort of fast-track THA and TKA with complete 90 days follow-up.Materials and methodsThis is an observational study on a consecutive cohort of primary unilateral THAs and TKAs performed between January 2010 and August 2017 in nine Danish high-volume fast-track centers. Discharge summaries and relevant patient records were reviewed in patients with readmissions within 90 days or LOS > 4 days caused by gastrointestinal complications.ResultsThe cohort included 36,932 patients with 58.3% females and 54.1% THAs. Mean age and BMI were 68 years and 28. Median postoperative LOS was 2 days. Only n: 276 (0.75 %) had a LOS > 4 days or a readmission within 90 days due to a gastrointestinal complication (CI 0.67%–0.84%). Of these, only 34 (0.09%) were graded as severe ileus or gastrointestinal bleeding.ConclusionsThe risk of GI-complications within the first 90 postoperative days after fast-track THA and TKA was low (0.75%). IntroductionGastrointestinal complications after total hip (THA) and knee arthroplasty (TKA) have been reported to be between 0.3 and 2.6% with bleeding and C. difficile infection in 0–1%, and 0.1–1.7%, respectively. The use of enhanced recovery or “fast-track” protocols have focused on optimizing all aspects of perioperative care resulting in reduced length of hospital stay (LOS) and potentially also gastrointestinal complications. This study is a detailed analysis on the occurrence of postoperative gastrointestinal complications resulting in increased hospital stay or readmissions in a large consecutive cohort of fast-track THA and TKA with complete 90 days follow-up.Materials and methodsThis is an observational study on a consecutive cohort of primary unilateral THAs and TKAs performed between January 2010 and August 2017 in nine Danish high-volume fast-track centers. Discharge summaries and relevant patient records were reviewed in patients with readmissions within 90 days or LOS > 4 days caused by gastrointestinal complications.ResultsThe cohort included 36,932 patients with 58.3% females and 54.1% THAs. Mean age and BMI were 68 years and 28. Median postoperative LOS was 2 days. Only n: 276 (0.75 %) had a LOS > 4 days or a readmission within 90 days due to a gastrointestinal complication (CI 0.67%–0.84%). Of these, only 34 (0.09%) were graded as severe ileus or gastrointestinal bleeding.ConclusionsThe risk of GI-complications within the first 90 postoperative days after fast-track THA and TKA was low (0.75%).

Published
2023

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