85,757 results on '"Keating A"'
Search Results
52. Detection of X-ray Polarization from the Blazar 1ES 1959+650 with the Imaging X-ray Polarimetry Explorer
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Errando, Manel, Liodakis, Ioannis, Marscher, Alan P., Marshall, Herman L., Middei, Riccardo, Negro, Michela, Peirson, Abel Lawrence, Perri, Matteo, Puccetti, Simonetta, Rabinowitz, Pazit L., Agudo, Iván, Jorstad, Svetlana G., Savchenko, Sergey S., Blinov, Dmitry, Bourbah, Ioakeim G., Kiehlmann, Sebastian, Kontopodis, Evangelos, Mandarakas, Nikos, Romanopoulos, Stylianos, Skalidis, Raphael, Vervelaki, Anna, Aceituno, Francisco José, Bernardos, Maria I., Bonnoli, Giacomo, Casanova, Víctor, Agís-González, Beatriz, Husillos, César, Marchini, Alessandro, Sota, Alfredo, Kouch, Pouya M., Lindfors, Elina, Casadio, Carolina, Escudero, Juan, Myserlis, Ioannis, Imazawa, Ryo, Sasada, Mahito, Fukazawa, Yasushi, Kawabata, Koji S., Uemura, Makoto, Mizuno, Tsunefumi, Nakaoka, Tatsuya, Akitaya, Hiroshi, Gurwell, Mark, Keating, Garrett K., Rao, Ramprasad, Ingram, Adam, Massaro, Francesco, Antonelli, Lucio Angelo, Bonino, Raffaella, Cavazzuti, Elisabetta, Chen, Chien-Ting, Cibrario, Nicolò, Ciprini, Stefano, De Rosa, Alessandra, Di Gesu, Laura, Di Pierro, Federico, Donnarumma, Immacolata, Ehlert, Steven R., Fenu, Francesco, Gau, Ephraim, Karas, Vladimir, Kim, Dawoon E., Krawczynski, Henric, Laurenti, Marco, Lisalda, Lindsey, López-Coto, Rubén, Madejski, Grzegorz, Marin, Frédéric, Marinucci, Andrea, Mitsuishi, Ikuyuki, Muleri, Fabio, Pacciani, Luigi, Paggi, Alessandro, Petrucci, Pierre-Olivier, Cavero, Nicole Rodriguez, Romani, Roger W., Tavecchio, Fabrizio, Tugliani, Stefano, Wu, Kinwah, Bachetti, Matteo, Baldini, Luca, Baumgartner, Wayne H., Bellazzini, Ronaldo, Bianchi, Stefano, Bongiorno, Stephen D., Brez, Alessandro, Bucciantini, Niccolò, Capitanio, Fiamma, Castellano, Simone, Costa, Enrico, Del Monte, Ettore, Di Lalla, Niccolò, Di Marco, Alessandro, Doroshenko, Victor, Dovčiak, Michal, Enoto, Teruaki, Evangelista, Yuri, Fabiani, Sergio, Ferrazzoli, Riccardo, Garcia, Javier A., Gunji, Shuichi, Hayashida, Kiyoshi, Heyl, Jeremy, Iwakiri, Wataru, Kaaret, Philip, Kislat, Fabian, Kitaguchi, Takao, Kolodziejczak, Jeffery J., La Monaca, Fabio, Latronico, Luca, Maldera, Simone, Manfreda, Alberto, Matt, Giorgio, Ng, C. -Y., O'Dell, Stephen L., Omodei, Nicola, Oppedisano, Chiara, Papitto, Alessandro, Pavlov, George G., Pesce-Rollins, Melissa, Pilia, Maura, Possenti, Andrea, Poutanen, Juri, Ramsey, Brian D., Rankin, John, Ratheesh, Ajay, Roberts, Oliver J., Sgrò, Carmelo, Slane, Patrick, Soffitta, Paolo, Spandre, Gloria, Swartz, Douglas A., Tamagawa, Toru, Taverna, Roberto, Tawara, Yuzuru, Tennant, Allyn F., Thomas, Nicholas E., Tombesi, Francesco, Trois, Alessio, Tsygankov, Sergey S., Turolla, Roberto, Vink, Jacco, Weisskopf, Martin C., Xie, Fei, and Zane, Silvia
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Observations of linear polarization in the 2-8 keV energy range with the Imaging X-ray Polarimetry Explorer (IXPE) explore the magnetic field geometry and dynamics of the regions generating non-thermal radiation in relativistic jets of blazars. These jets, particularly in blazars whose spectral energy distribution peaks at X-ray energies, emit X-rays via synchrotron radiation from high-energy particles within the jet. IXPE observations of the X-ray selected BL Lac-type blazar 1ES 1959+650 in 2022 May 3-4 showed a significant linear polarization degree of $\Pi_\mathrm{x} = 8.0\% \pm 2.3\%$ at an electric-vector position angle $\psi_\mathrm{x} = 123^\circ \pm 8^\circ$. However, in 2022 June 9-12, only an upper limit of $\Pi_\mathrm{x} \leq 5.1\%$ could be derived (at the 99% confidence level). The degree of optical polarization at that time $\Pi_\mathrm{O} \sim 5\%$ is comparable to the X-ray measurement. We investigate possible scenarios for these findings, including temporal and geometrical depolarization effects. Unlike some other X-ray selected BL Lac objects, there is no significant chromatic dependence of the measured polarization in 1ES 1959+650, and its low X-ray polarization may be attributed to turbulence in the jet flow with dynamical timescales shorter than 1 day., Comment: 16 pages, 4 figures, accepted for publication in The Astrophysical Journal
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- 2024
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53. Antiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II interventional trial of pediatric patients with risk factor assessment.
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Keller, Michael, Hanley, Patrick, Chi, Yueh-Yun, Aguayo-Hiraldo, Paibel, Verneris, Michael, Kohn, Donald, Pai, Sung-Yun, Dávila Saldaña, Blachy, Hanisch, Benjamin, Quigg, Troy, Adams, Roberta, Dahlberg, Ann, Chandrakasan, Shanmuganathan, Hasan, Hasibul, Malvar, Jemily, Jensen-Wachspress, Mariah, Lazarski, Christopher, Sani, Gelina, Idso, John, Lang, Haili, Chansky, Pamela, McCann, Chase, Tanna, Jay, Abraham, Allistair, Webb, Jennifer, Shibli, Abeer, Keating, Amy, Satwani, Prakash, Muranski, Pawel, Hall, Erin, Eckrich, Michael, Shereck, Evan, Miller, Holly, Mamcarz, Ewelina, Agarwal, Rajni, Vander Lugt, Mark, Ebens, Christen, Aquino, Victor, Bednarski, Jeffrey, Chu, Julia, Parikh, Suhag, Whangbo, Jennifer, Lionakis, Michail, Zambidis, Elias, Gourdine, Elizabeth, Bollard, Catherine, Pulsipher, Michael, Dvorak, Christopher, and De Oliveira, Satiro
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Humans ,Child ,Epstein-Barr Virus Infections ,Herpesvirus 4 ,Human ,Virus Diseases ,Risk Factors ,Hematopoietic Stem Cell Transplantation - Abstract
Viral infections remain a major risk in immunocompromised pediatric patients, and virus-specific T cell (VST) therapy has been successful for treatment of refractory viral infections in prior studies. We performed a phase II multicenter study (NCT03475212) for the treatment of pediatric patients with inborn errors of immunity and/or post allogeneic hematopoietic stem cell transplant with refractory viral infections using partially-HLA matched VSTs targeting cytomegalovirus, Epstein-Barr virus, or adenovirus. Primary endpoints were feasibility, safety, and clinical responses (>1 log reduction in viremia at 28 days). Secondary endpoints were reconstitution of antiviral immunity and persistence of the infused VSTs. Suitable VST products were identified for 75 of 77 clinical queries. Clinical responses were achieved in 29 of 47 (62%) of patients post-HSCT including 73% of patients evaluable at 1-month post-infusion, meeting the primary efficacy endpoint (>52%). Secondary graft rejection occurred in one child following VST infusion as described in a companion article. Corticosteroids, graft-versus-host disease, transplant-associated thrombotic microangiopathy, and eculizumab treatment correlated with poor response, while uptrending absolute lymphocyte and CD8 T cell counts correlated with good response. This study highlights key clinical factors that impact response to VSTs and demonstrates the feasibility and efficacy of this therapy in pediatric HSCT.
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- 2024
54. Interfacial Assembly of Bacterial Microcompartment Shell Proteins in Aqueous Multiphase Systems
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Abeysinghe, AA Dharani T, Young, Eric J, Rowland, Andrew T, Dunshee, Lucas C, Urandur, Sandeep, Sullivan, Millicent O, Kerfeld, Cheryl A, and Keating, Christine D
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Biochemistry and Cell Biology ,Biological Sciences ,Bioengineering ,Dextrans ,Bacterial Proteins ,bioreactor ,bottom-up synthetic biology ,compartmentalization ,protocell ,self-assembly ,synthetic cell ,bottom‐up synthetic biology ,self‐assembly ,Nanoscience & Nanotechnology - Abstract
Compartments are a fundamental feature of life, based variously on lipid membranes, protein shells, or biopolymer phase separation. Here, this combines self-assembling bacterial microcompartment (BMC) shell proteins and liquid-liquid phase separation (LLPS) to develop new forms of compartmentalization. It is found that BMC shell proteins assemble at the liquid-liquid interfaces between either 1) the dextran-rich droplets and PEG-rich continuous phase of a poly(ethyleneglycol)(PEG)/dextran aqueous two-phase system, or 2) the polypeptide-rich coacervate droplets and continuous dilute phase of a polylysine/polyaspartate complex coacervate system. Interfacial protein assemblies in the coacervate system are sensitive to the ratio of cationic to anionic polypeptides, consistent with electrostatically-driven assembly. In both systems, interfacial protein assembly competes with aggregation, with protein concentration and polycation availability impacting coating. These two LLPS systems are then combined to form a three-phase system wherein coacervate droplets are contained within dextran-rich phase droplets. Interfacial localization of BMC hexameric shell proteins is tunable in a three-phase system by changing the polyelectrolyte charge ratio. The tens-of-micron scale BMC shell protein-coated droplets introduced here can accommodate bioactive cargo such as enzymes or RNA and represent a new synthetic cell strategy for organizing biomimetic functionality.
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- 2024
55. Methodological Pluralism in Political Science
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della Porta, Donatella, Keating, Michael, Box-Steffensmeier, Janet M., book editor, Christenson, Dino P., book editor, and Sinclair-Chapman, Valeria, book editor
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- 2024
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56. Tuberculosis in otherwise healthy adults with inherited TNF deficiency
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Arias, Andrés A., Neehus, Anna-Lena, Ogishi, Masato, Meynier, Vincent, Krebs, Adam, Lazarov, Tomi, Lee, Angela M., Arango-Franco, Carlos A., Yang, Rui, Orrego, Julio, Corcini Berndt, Melissa, Rojas, Julian, Li, Hailun, Rinchai, Darawan, Erazo-Borrás, Lucia, Han, Ji Eun, Pillay, Bethany, Ponsin, Khoren, Chaldebas, Matthieu, Philippot, Quentin, Bohlen, Jonathan, Rosain, Jérémie, Le Voyer, Tom, Janotte, Till, Amarajeeva, Krishnajina, Soudée, Camille, Brollo, Marion, Wiegmann, Katja, Marquant, Quentin, Seeleuthner, Yoann, Lee, Danyel, Lainé, Candice, Kloos, Doreen, Bailey, Rasheed, Bastard, Paul, Keating, Narelle, Rapaport, Franck, Khan, Taushif, Moncada-Vélez, Marcela, Carmona, María Camila, Obando, Catalina, Alvarez, Jesús, Cataño, Juan Carlos, Martínez-Rosado, Larry Luber, Sanchez, Juan P., Tejada-Giraldo, Manuela, L’Honneur, Anne-Sophie, Agudelo, María L., Perez-Zapata, Lizet J., Arboleda, Diana M., Alzate, Juan Fernando, Cabarcas, Felipe, Zuluaga, Alejandra, Pelham, Simon J., Ensser, Armin, Schmidt, Monika, Velásquez-Lopera, Margarita M., Jouanguy, Emmanuelle, Puel, Anne, Krönke, Martin, Ghirardello, Stefano, Borghesi, Alessandro, Pahari, Susanta, Boisson, Bertrand, Pittaluga, Stefania, Ma, Cindy S., Emile, Jean-François, Notarangelo, Luigi D., Tangye, Stuart G., Marr, Nico, Lachmann, Nico, Salvator, Hélène, Schlesinger, Larry S., Zhang, Peng, Glickman, Michael S., Nathan, Carl F., Geissmann, Frédéric, Abel, Laurent, Franco, José Luis, Bustamante, Jacinta, Casanova, Jean-Laurent, and Boisson-Dupuis, Stéphanie
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- 2024
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57. Effect of low-volume combined aerobic and resistance high-intensity interval training on vascular health in people with type 2 diabetes: a randomised controlled trial
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Cox, Emily R., Gajanand, Trishan, Keating, Shelley E., Hordern, Matthew D., Burton, Nicola W., Green, Daniel J., Ramos, Joyce S., Ramos, Maximiano V., Fassett, Robert G., Cox, Stephen V., Coombes, Jeff S., and Bailey, Tom G.
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- 2024
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58. An investigation of the longitudinal trajectory patterns of health-related quality of life among Australians with disabilities: explaining disability types and properties
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Hashmi, Rubayyat, Keating, Byron W., Ali, Mohammad Afshar, and Keramat, Syed Afroz
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- 2024
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59. Outcomes of surgical revascularization for pediatric moyamoya disease and syndrome
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Boulter, Jason H., Szuflita, Nicholas S., Keating, Robert F., and Magge, Suresh N.
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- 2024
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60. Molecular ontogeny underlies the benefit of adding venetoclax to hypomethylating agents in newly diagnosed AML patients
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Shimony, Shai, Garcia, Jacqueline S., Keating, Julia, Chen, Evan C., Luskin, Marlise R., Stahl, Maximilian, Neuberg, Donna S., DeAngelo, Daniel J., Stone, Richard M., and Lindsley, R. Coleman
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- 2024
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61. Donor genetic burden for cerebrovascular risk and kidney transplant outcome
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Collins, Kane E., Gilbert, Edmund, Mauduit, Vincent, Benson, Katherine A., Elhassan, Elhussein A. E., O’Seaghdha, Conall, Hill, Claire, McKnight, Amy Jayne, Maxwell, Alexander P., van der Most, Peter J., de Borst, Martin H., Guan, Weihua, Jacobson, Pamala A., Israni, Ajay K., Keating, Brendan J., Lord, Graham M., Markkinen, Salla, Helanterä, Ilkka, Hyvärinen, Kati, Partanen, Jukka, Madden, Stephen F., Limou, Sophie, Cavalleri, Gianpiero L., and Conlon, Peter J.
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- 2024
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62. First characterization of the emission behavior of Mrk421 from radio to VHE gamma rays with simultaneous X-ray polarization measurements
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Abe, S., Abhir, J., Acciari, V. A., Agudo, I., Aniello, T., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Arcaro, C., Artero, M., Asano, K., Babić, A., Baquero, A., de Almeida, U. Barres, Barrio, J. A., Batković, I., Baxter, J., González, J. Becerra, Bednarek, W., Bernardini, E., Bernete, J., Berti, A., Besenrieder, J., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bošnjak, Ž., Burelli, I., Busetto, G., Campoy-Ordaz, A., Carosi, A., Carosi, R., Carretero-Castrillo, M., Castro-Tirado, A. J., Ceribella, G., Chai, Y., Cifuentes, A., Cikota, S., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Ammando, F., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., de Menezes, R., Del Popolo, A., Delgado, J., Mendez, C. Delgado, Di Pierro, F., Di Venere, L., Prester, D. Dominis, Donini, A., Dorner, D., Doro, M., Elsaesser, D., Emery, G., Escudero, J., Fariña, L., Fattorini, A., Foffano, L., Font, L., Fröse, S., Fukami, S., Fukazawa, Y., López, R. J. García, Garczarczyk, M., Gasparyan, S., Gaug, M., Paiva, J. G. Giesbrecht, Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Gradetzke, T., Grau, R., Green, D., Green, J. G., Günther, P., Hadasch, D., Hahn, A., Hassan, T., Heckmann, L., Herrera, J., Hrupec, D., Hütten, M., Imazawa, R., Inada, T., Ishio, K., Martínez, I. Jiménez, Jormanainen, J., Kerszberg, D., Kluge, G. W., Kobayashi, Y., Kouch, P. M., Kubo, H., Kushida, J., Lezáun, M. Láinez, Lamastra, A., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Lorini, A., Fraga, B. Machado de Oliveira, Majumdar, P., Makariev, M., Maneva, G., Mang, N., Manganaro, M., Mangano, S., Mannheim, K., Mariotti, M., Martínez, M., Martínez-Chicharro, M., Mas-Aguilar, A., Mazin, D., Menchiari, S., Mender, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., González, M. Molero, Molina, E., Mondal, H. A., Moralejo, A., Morcuende, D., Nakamori, T., Nanci, C., Nava, L., Neustroev, V., Nickel, L., Rosillo, M. Nievas, Nigro, C., Nikolić, L., Nilsson, K., Nishijima, K., Ekoume, T. Njoh, Noda, K., Nozaki, S., Ohtani, Y., Okumura, A., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavlović, D., Peresano, M., Persic, M., Pihet, M., Pirola, G., Podobnik, F., Moroni, P. G. Prada, Prandini, E., Principe, G., Priyadarshi, C., Rhode, W., Ribó, M., Rico, J., Righi, C., Sahakyan, N., Saito, T., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schmuckermaier, F., Schubert, J. L., Schweizer, T., Sciaccaluga, A., Sitarek, J., Sliusar, V., Sobczynska, D., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Suutarinen, S., Tajima, H., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terauchi, K., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Acosta, M. Vazquez, Ventura, S., Viale, I., Vigorito, C. F., Vitale, V., Vovk, I., Walter, R., Will, M., Wunderlich, C., Yamamoto, T., Liodakis, I., Jorstad, S. G., Gesu, L. D., Donnarumma, I., Kim, D. E., Marscher, A. P., Middei, R., Perri, M., Puccetti, S., Verrecchia, F., Leto, C., Pérez, I. De La Calle, Jiménez-Bailón, E., Blinov, D., Bourbah, I. G., Kiehlmann, S., Kontopodis, E., Mandarakas, N., Skalidis, R., Vervelaki, A., Aceituno, F. J., Agís-González, B., Sota, A., Sasada, M., Kawabata, K. S., Uemura, M., Mizuno, T., Akitaya, H., Casadio, C., Myserlis, I., Sievers, A., Lähteenmäki, A., Syrjärinne, I., Tornikoski, M., Salomé, Q., Gurwell, M., Keating, G. K., and Rao, R.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We perform the first broadband study of Mrk421 from radio to TeV gamma rays with simultaneous measurements of the X-ray polarization from IXPE. The data were collected within an extensive multiwavelength campaign organized between May and June 2022 using MAGIC, Fermi-LAT, NuSTAR, XMM-Newton, Swift, and several optical and radio telescopes to complement IXPE. During the IXPE exposures, the measured 0.2-1 TeV flux is close to the quiescent state and ranges from 25% to 50% of the Crab Nebula without intra-night variability. Throughout the campaign, the VHE and X-ray emission are positively correlated at a $4\sigma$ significance level. The IXPE measurements unveil a X-ray polarization degree that is a factor of 2-5 higher than in the optical/radio bands; that implies an energy-stratified jet in which the VHE photons are emitted co-spatially with the X-rays, in the vicinity of a shock front. The June 2022 observations exhibit a rotation of the X-ray polarization angle. Despite no simultaneous VHE coverage being available during a large fraction of the swing, the Swift-XRT monitoring unveils an X-ray flux increase with a clear spectral hardening. It suggests that flares in high synchrotron peaked blazars can be accompanied by a polarization angle rotation, as observed in some flat spectrum radio quasars. Finally, during the polarization angle rotation, NuSTAR data reveal two contiguous spectral hysteresis loops in opposite directions (clockwise and counter-clockwise), implying important changes in the particle acceleration efficiency on $\sim$hour timescales., Comment: Accepted for publication in Astronomy & Astrophysics. 29 pages, 22 figures. Corresponding authors: Axel Arbet Engels, Felix Schmuckermaier, David Paneque
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- 2023
63. Constraints on the Evolution of the Ionizing Background and Ionizing Photon Mean Free Path at the End of Reionization
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Davies, Frederick B., Bosman, Sarah E. I., Gaikwad, Prakash, Nasir, Fahad, Hennawi, Joseph F., Becker, George D., Haehnelt, Martin G., D'Odorico, Valentina, Bischetti, Manuela, Eilers, Anna-Christina, Keating, Laura C., Kulkarni, Girish, Lai, Samuel, Mazzucchelli, Chiara, Qin, Yuxiang, Satyavolu, Sindhu, Wang, Feige, Yang, Jinyi, and Zhu, Yongda
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The variations in Ly$\alpha$ forest opacity observed at $z>5.3$ between lines of sight to different background quasars are too strong to be caused by fluctuations in the density field alone. The leading hypothesis for the cause of this excess variance is a late, ongoing reionization process at redshifts below six. Another model proposes strong ionizing background fluctuations coupled to a short, spatially varying mean free path of ionizing photons, without explicitly invoking incomplete reionization. With recent observations suggesting a short mean free path at $z\sim6$, and a dramatic improvement in $z>5$ Ly$\alpha$ forest data quality, we revisit this latter possibility. Here we apply the likelihood-free inference technique of approximate Bayesian computation to jointly constrain the hydrogen photoionization rate $\Gamma_{\rm HI}$ and the mean free path of ionizing photons $\lambda_{\rm mfp}$ from the effective optical depth distributions at $z=5.0$-$6.1$ from XQR-30. We find that the observations are well-described by fluctuating mean free path models with average mean free paths that are consistent with the steep trend implied by independent measurements at $z\sim5$-$6$, with a concomitant rapid evolution of the photoionization rate., Comment: 23 pages, 13 figures, resubmitted to ApJ after referee's comments
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- 2023
64. Metadata for the Flux Density Calibration of the April 2018 Event Horizon Telescope Data
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Koay, J. Y., Romero-Cañizales, C., Matthews, L. D., Janssen, M., Blackburn, L., Tilanus, R. P. J., Park, J., Asada, K., Matsushita, S., Baczko, A. -K., La Bella, N., Chan, C. -K., Crew, G. B., Fish, V., Patel, N., Ramakrishnan, V., Rottmann, H., Wagner, J., Wiik, K., Friberg, P., Goddi, C., Issaoun, S., Keating, G., Kim, J., Krichbaum, T. P., Marrone, D., Narayanan, G., Roy, A., Ruíz, I., Sánchez, S., Torne, P., and Weintroub, J.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Event Horizon Telescope (EHT) observations carried out in 2018 April at 1.3 mm wavelengths included 9 stations in the array, comprising 7 single-dish telescopes and 2 phased arrays. The metadata package for the 2018 EHT observing campaign contains calibration tables required for the a-priori amplitude calibration of the 2018 April visibility data. This memo is the official documentation accompanying the release of the 2018 EHT metadata package, providing an overview of the contents of the package. We describe how telescope sensitivities, gain curves and other relevant parameters for each station in the EHT array were collected, processed, and validated to produce the calibration tables., Comment: 26 pages, 7 figures, EHT Memo Series 2023-L1-01
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- 2023
65. Lecture hall graphs and the Askey scheme
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Corteel, Sylvie, Jonnadula, Bhargavi, Keating, Jonathan P., and Kim, Jang Soo
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Mathematics - Combinatorics ,Mathematical Physics ,Mathematics - Classical Analysis and ODEs ,05A15 (primary) 33D45, 05A10, 05A19, 05A30 (secondary) - Abstract
We establish, for every family of orthogonal polynomials in the $q$-Askey scheme and the Askey scheme, a combinatorial model for mixed moments and coefficients in terms of paths on the lecture hall graph. This generalizes the previous results of Corteel and Kim for the little $q$-Jacobi polynomials. We build these combinatorial models by bootstrapping, beginning with polynomials at the bottom and working towards Askey-Wilson polynomials which sit at the top of the $q$-Askey scheme. As an application of the theory, we provide the first combinatorial proof of the symmetries in the parameters of the Askey-Wilson polynomials., Comment: 43 pages, 23 figures
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- 2023
66. Robustness of direct measurements of the mean free path of ionizing photons in the epoch of reionization
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Satyavolu, Sindhu, Kulkarni, Girish, Keating, Laura C., and Haehnelt, Martin G.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
Measurements of the mean free path of Lyman-continuum photons in the intergalactic medium during the epoch of reionization can help constrain the nature of the sources as well as sinks of hydrogen-ionizing radiation. A recent approach to this measurement has been to utilize composite spectra of multiple quasars at $z\sim 6$, and infer the mean free path after correcting the spectra for the presence of quasar proximity zones. This has revealed not only a steep drop in the mean free path from $z=5$ to $z=6$, but also potentially a mild tension with reionization simulations. We critically examine such direct measurements of the mean free path for biases due to quasar environment, incomplete reionization, and quasar proximity zones. Using cosmological radiative transfer simulations of reionization combined with one-dimensional radiative transfer calculations of quasar proximity zones, we find that the bias in the mean free path due to overdensities around quasars is minimal at $z\sim 6$. Patchiness of reionization at this redshift also does not affect the measurements significantly. Fitting our model to the data results in a mean free path of $\lambda_{\mathrm{mfp}}=1.49^{+0.47}_{-0.52}$~pMpc at $z=6$, which is consistent with the recent measurements in the literature, indicating robustness with respect to the modelling of quasar proximity zones. We also compare various ways in which the mean free path has been defined in simulations before the end of reionization. Overall, our finding is that recent measurements of the mean free path appear to be robust relative to several sources of potential bias., Comment: Accepted in MNRAS. Mean free path measurement revised to a higher value with narrower uncertainty using full data covariance
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- 2023
67. The ultraviolet continuum slopes of high-redshift galaxies: evidence for the emergence of dust-free stellar populations at z > 10
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Cullen, F., McLeod, D. J., McLure, R. J., Dunlop, J. S., Donnan, C. T., Carnall, A. C., Keating, L. C., Magee, D., Arellano-Cordova, K. Z., Bowler, R. A. A., Begley, R., Flury, S. R., Hamadouche, M. L., and Stanton, T. M.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present an analysis of the ultraviolet (UV) continuum slopes ($\beta$) for a sample of $172$ galaxy candidates at $8 < z_{\mathrm{phot}} < 16$ selected from a combination of JWST NIRCam imaging and COSMOS/UltraVISTA ground-based near-infrared imaging. Focusing primarily on a new sample of $121$ galaxies at $\langle z \rangle \simeq 11$ selected from $\simeq 320$ arcmin$^2$ of public JWST imaging data across $15$ independent data sets, we investigate the evolution of $\beta$ in the galaxy population at $z \geq 9$. We find a significant trend between $\beta$ and redshift, with the inverse-variance weighted mean UV slope evolving from $\langle \beta \rangle = -2.17 \pm 0.06$ at $z = 9.5$ to $\langle \beta \rangle = -2.59 \pm 0.06$ at $z = 11.5$. Based on a comparison with stellar population models including nebular continuum emission, we find that at $z>10.5$ the average UV continuum slope is consistent with the intrinsic blue limit of dust-free stellar populations $(\beta_{\mathrm{int}} \simeq -2.6)$. These results suggest that the moderately dust-reddened galaxy population at $z < 10$ was essentially unattenuated at $z \simeq 11$. The extremely blue galaxies being uncovered at $z>10$ place important constraints on dust attenuation in galaxies in the early Universe, and imply that the already observed galaxy population is likely supplying an ionising photon budget capable of maintaining ionised IGM fractions of $\gtrsim 5$ per cent at $z\simeq11$., Comment: 18 pages, 12 figures, MNRAS accepted
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- 2023
68. Magnetic Field Properties inside the Jet of Mrk 421: Multiwavelength Polarimetry Including the Imaging X-ray Polarimetry Explorer
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Kim, Dawoon E., Di Gesu, Laura, Liodakis, Ioannis, Marscher, Alan P., Jorstad, Svetlana G., Midde, Riccardo, Marshall, Herman L., Pacciani, Luigi, Agudo, Iván, Tavecchio, Fabrizio, Cibrario, Nicolò, Tugliani, Stefano, Bonino, Raffaella, Negro, Michela, Puccetti, Simonetta, Tombesi, Francesco, Costa, Enrico, Donnarumma, Immacolata, Soffitta, Paolo, Mizuno, Tsunefumi, Fukazawa, Yasushi, Kawabata, Koji S., Nakaoka, Tatsuya, Uemura, Makoto, Imazawa, Ryo, Sasada, Mahito, Akitaya, Hiroshi, Aceituno, Francisco Josè, Bonnoli, Giacomo, Casanova, Vìctor, Myserlis, Ioannis, Sievers, Albrecht, Angelakis, Emmanouil, Kraus, Alexander, Cheong, Whee Yeon, Jeong, Hyeon-Woo, Kang, Sincheol, Kim, Sang-Hyun, Lee, Sang-Sung, Agìs-Gonzàlez, Beatriz, Sota, Alfredo, Escudero, Juan, Gurwell, Mark, Keating, Garrett K., Rao, Ramprasad, Kouch, Pouya M., Lindfors, Elina, Bourbah, Ioakeim G., Kiehlmann, Sebastian, Kontopodis, Evangelos, Mandarakas, Nikos, Romanopoulos, Stylianos, Skalidis, Raphael, Vervelaki, Anna, Savchenko, Sergey S., Antonelli, Lucio A., Bachetti, Matteo, Baldini, Luca, Baumgartner, Wayne H., Bellazzini, Ronaldo, Bianchi, Stefano, Bongiorno, Stephen D., Brez, Alessandro, Bucciantini, Niccolò, Capitanio, Fiamma, Castellano, Simone, Cavazzuti, Elisabetta, Chen, Chien-Ting, Ciprini, Stefano, De Rosa, Alessandra, Del Monte, Ettore, Di Lalla, Niccolò, Di Marco, Alessandro, Doroshenko, Victor, Dovčiak, Michal, Ehlert, Steven R., Enoto, Teruaki, Evangelista, Yuri, Fabiani, Sergio, Ferrazzoli, Riccardo, Garcia, Javier A., Gunji, Shuichi, Hayashida, Kiyoshi, Heyl, Jeremy, Iwakiri, Wataru, Kaaret, Philip, Karas, Vladimir, Kislat, Fabian, Kitaguchi, Takao, Kolodziejczak, Jeffery J., Krawczynski, Henric, La Monaca, Fabio, Latronico, Luca, Maldera, Simone, Manfreda, Alberto, Marin, Frédéric, Marinucci, Andrea, Massaro, Francesco, Matt, Giorgio, Mitsuishi, Ikuyuki, Muleri, Fabio, Ng, C. -Y., O'Dell, Stephen L., Omodei, Nicola, Oppedisano, Chiara, Papitto, Alessandro, Pavlov, George G., Peirson, Abel L., Perri, Matteo, Pesce-Rollins, Melissa, Petrucci, Pierre-Olivier, Pilia, Maura, Possenti, Andrea, Poutanen, Juri, Ramsey, Brian D., Rankin, John, Ratheesh, Ajay, Roberts, Oliver, Romani, Roger W., Sgrò, Carmelo, Slane, Patrick, Spandre, Gloria, Swartz, Doug, Tamagawa, Toru, Taverna, Roberto, Tawara, Yuzuru, Tennant, Allyn F., Thomas, Nicholas E., Trois, Alessio, Tsygankov, Sergey S., Turolla, Roberto, Vink, Jacco, Weisskopf, Martin C., Wu, Kinwah, Xie, Fei, and Zane, Silvia
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We conducted a polarimetry campaign from radio to X-ray wavelengths of the high-synchrotron-peak (HSP) blazar Mrk 421, including Imaging X-ray Polarimetry Explorer (IXPE) measurements on 2022 December 6-8. We detected X-ray polarization of Mrk 421 with a degree of $\Pi_{\rm X}$=14$\pm$1$\%$ and an electric-vector position angle $\psi_{\rm X}$=107$\pm$3$^{\circ}$ in the 2-8 keV band. From the time variability analysis, we find a significant episodic variation in $\psi_{\rm X}$. During 7 months from the first IXPE pointing of Mrk 421 in 2022 May, $\psi_{\rm X}$ varied across the range of 0$^{\circ}$ to 180$^{\circ}$, while $\Pi_{\rm X}$ maintained similar values within $\sim$10-15$\%$. Furthermore, a swing in $\psi_{\rm X}$ in 2022 June was accompanied by simultaneous spectral variations. The results of the multiwavelength polarimetry show that the X-ray polarization degree was generally $\sim$2-3 times greater than that at longer wavelengths, while the polarization angle fluctuated. Additionally, based on radio, infrared, and optical polarimetry, we find that rotation of $\psi$ occurred in the opposite direction with respect to the rotation of $\psi_{\rm X}$ over longer timescales at similar epochs. The polarization behavior observed across multiple wavelengths is consistent with previous IXPE findings for HSP blazars. This result favors the energy-stratified shock model developed to explain variable emission in relativistic jets. The accompanying spectral variation during the $\psi_{\rm X}$ rotation can be explained by a fluctuation in the physical conditions, e.g., in the energy distribution of relativistic electrons. The opposite rotation direction of $\psi$ between the X-ray and longer-wavelength polarization accentuates the conclusion that the X-ray emitting region is spatially separated from that at longer wavelengths., Comment: 17 pages, 13 figures, 4 tables; Accepted for publication in A&A
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- 2023
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69. Searching for [CII] Emission from the First Sample of $z\sim 6$ OI Absorption-Associated Galaxies with ALMA
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Wu, Yunjing, Cai, Zheng, Li, Jianan, Finlator, Kristian, Neeleman, Marcel, Prochaska, J. Xavier, Emonts, Bjorn H. C., Zhang, Shiwu, Wang, Feige, Yang, Jinyi, Wang, Ran, Fan, Xiaohui, Xu, Dandan, Golden-Marx, Emmet, Keating, Laura C., and Hennawi, Joseph F.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We report the first statistical analyses of [CII] and dust continuum observations in six strong OI absorber fields at the end of the reionization epoch obtained by the Atacama Large Millimeter/Submillimeter Array (ALMA). Combined with one [CII] emitter reported in Wu et al. (2021), we detect one OI-associated [CII] emitter in six fields. At redshifts of OI-absorbers in non-detection fields, no emitters are brighter than our detection limit within impact parameters of 50 kpc and velocity offsets between $\pm200\ {\rm km\ s^{-1}}$. The averaged [CII]-detection upper limit is $< 0.06$ Jy ${\rm km\ s^{-1}}$ (3$\sigma$), corresponding to the [CII] luminosity of $L_{\rm [CII]} <5.8\times 10^7\ L_{\odot}$ and the [CII]-based star formation rate of ${\rm SFR_{\rm [CII]}} < 5.5$ $M_\odot$ yr$^{-1}$. Cosmological simulations suggest that only $\sim10^{-2.5}$ [CII] emitters around [OI] absorbers have comparable SFR to our detection limit. Although the detection in one out of six fields is reported, an order of magnitude number excess of emitters obtained from our ALMA observations supports that the contribution of massive galaxies that caused the metal enrichment cannot be ignored. Further, we also found 14 tentative galaxy candidates with S/N of $\approx4.3$ at large impact parameters ($>50$ kpc) and having larger outflow velocities within $\pm 600$ km s$^{-1}$. If these detections are confirmed in the future, then the mechanism of pushing metals at larger distances with higher velocities needs to be further explored from the theoretical side., Comment: Accepted for publication in ApJ. Main text 10 pages, 5 figures
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- 2023
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70. X-ray Polarization of the BL Lac Type Blazar 1ES 0229+200
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Ehlert, Steven R., Liodakis, Ioannis, Middei, Riccardo, Marscher, Alan P., Tavecchio, Fabrizio, Agudo, Iván, Kouch, Pouya M., Lindfors, Elina, Nilsson, Kari, Myserlis, Ioannis, Gurwell, Mark, Rao, Ramprasad, Aceituno, Francisco Jose, Bonnoli, Giacomo, Casanova, Victor, Agiz-Gonzalez, Beatriz, Escudero, Juan, Santos, Jorge Otero, Sota, Alfredo, Angelakis, Emmanouil, Kraus, Alexander, Keating, Garrett K., Antonelli, Lucio A., Bachetti, Matteo, Baldini, Luca, Baumgartner, Wayne H., Bellazzini, Ronaldo, Bianchi, Stefano, Bongiorno, Stephen D., Bonino, Raffaella, Brez, Alessandro, Bucciantini, Niccolò, Capitanio, Fiamma, Castellano, Simone, Cavazzuti, Elisabetta, Chen, Chien-Ting, Ciprini, Stefano, Costa, Enrico, De Rosa, Alessandra, Del Monte, Ettore, Di Gesu, Laura, Di Lalla, Niccolò, Di Marco, Alessandro, Donnarumma, Immacolata, Doroshenko, Victor, Dovčiak, Michal, Enoto, Teruaki, Evangelista, Yuri, Fabiani, Sergio, Ferrazzoli, Riccardo, Garcia, Javier A., Gunji, Shuichi, Hayashida, Kiyoshi, Heyl, Jeremy, Iwakiri, Wataru, Jorstad, Svetlana G., Kaaret, Philip, Karas, Vladimir, Kislat, Fabian, Kitaguchi, Takao, Kolodziejczak, Jeffery J., Krawczynski, Henric, La Monaca, Fabio, Latronico, Luca, Maldera, Simone, Manfreda, Alberto, Marin, Frédéric, Marinucci, Andrea, Marshall, Herman L., Massaro, Francesco, Matt, Giorgio, Mitsuishi, Ikuyuki, Mizuno, Tsunefumi, Muleri, Fabio, Negro, Michela, Ng, C. -Y., O'Dell, Stephen L., Omodei, Nicola, Oppedisano, Chiara, Papitto, Alessandro, Pavlov, George G., Peirson, Abel L., Perri, Matteo, Pesce-Rollins, Melissa, Petrucci, Pierre-Olivier, Pilia, Maura, Possenti, Andrea, Poutanen, Juri, Puccetti, Simonetta, Ramsey, Brian D., Rankin, John, Ratheesh, Ajay, Roberts, Oliver J., Romani, Roger W., Sgro, Carmelo, Slane, Patrick, Soffitta, Paolo, Spandre, Gloria, Swartz, Douglas A., Tamagawa, Toru, Taverna, Roberto, Tawara, Yuzuru, Tennant, Allyn F., Thomas, Nicholas E., Tombesi, Francesco, Trois, Alessio, Tsygankov, Sergey S., Turolla, Roberto, Vink, Jacco, Weisskopf, Martin C., Wu, Kinwah, Xie, Fei, and Zane, Silvia
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present polarization measurements in the $2-8 \thinspace \mathrm{keV}$ band from blazar 1ES 0229+200, the first extreme high synchrotron peaked source to be observed by the Imaging X-ray Polarimetry Explorer (IXPE). Combining two exposures separated by about two weeks, we find the degree of polarization to be $\Pi_{X} = 17.9 \pm 2.8 \%$ at an electric-vector position angle $\psi_X = 25.0 \pm 4.6^{\circ}$ using a spectropolarimetric fit from joint IXPE and XMM-Newton observations. There is no evidence for the polarization degree or angle varying significantly with energy or time on both short time scales (hours) or longer time scales (days). The contemporaneous polarization degree at optical wavelengths was $>$7$\times$ lower, making 1ES 0229+200 the most strongly chromatic blazar yet observed. This high X-ray polarization compared to the optical provides further support that X-ray emission in high-peaked blazars originates in shock-accelerated, energy-stratified electron populations, but is in tension with many recent modeling efforts attempting to reproduce the spectral energy distribution of 1ES 0229+200 which attribute the extremely high energy synchrotron and Compton peaks to Fermi acceleration in the vicinity of strongly turbulent magnetic fields., Comment: 17 Pages, 6 Figures, Resubmitted to ApJ after addressing referee comments
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- 2023
71. Commentary on the 2019 safer care Victoria review of chiropractic spinal manipulation of children under 12 years
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Keating, Genevieve and Amorin-Woods, Lyndon G
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- 2023
72. A Phase 1 Study of Cabozantinib and Trifluridine/Tipiracil in Metastatic Colorectal Adenocarcinoma
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Dayyani, Farshid, Balangue, Jasmine, Valerin, Jennifer, Keating, Matthew J, Zell, Jason A, Taylor, Thomas H, and Cho, May T
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Clinical Research ,Clinical Trials and Supportive Activities ,Cancer ,Colo-Rectal Cancer ,Digestive Diseases ,6.1 Pharmaceuticals ,Good Health and Well Being ,Humans ,Male ,Middle Aged ,Uracil ,Trifluridine ,Frontotemporal Dementia ,Colorectal Neoplasms ,Drug Combinations ,Antineoplastic Combined Chemotherapy Protocols ,Adenocarcinoma ,Neutropenia ,Anilides ,Pyridines ,Pyrrolidines ,Thymine ,Angiogenesis ,Axl ,cMET ,Recommended phase II dose ,Resistance ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
IntroductionThis study determined the safety and recommended phase 2 dose (RP2D) of the multikinase inhibitor cabozantinib in combination with trifluridine/tipiracil (FTD/TPI) in refractory metastatic colorectal carcinoma (mCRC).Patients and methodsSingle institution investigator-initiated phase 1 study using 3+3 design. Eligible mCRC patients had received prior standard regimens. Cabozantinib was given orally (p.o.) at 20 mg (dose level [DL] 0) or 40 mg (DL 1) daily on days 1-28, and FTD/TPI p.o. at 35 mg/m2 on days 1-5 and 8-12 every 28 days. Prophylactic growth-factor support was allowed.ResultsFifteen patients were enrolled. Median age 56 years (31-80), male (12/15), ECOG 0/1 = 9/6. Three patients were treated at DL 0 and another nine were treated at DL 1, none exhibiting a DLT. Most common any grade (G) treatment related adverse events (TRAE) were diarrhea (50%), nausea (42%), neutropenia (42%), fatigue (33%), and rash (25%). G3-4 TRAE were neutropenia (25%) and thrombocytopenia, hypokalemia, and weight loss (each 8%). No serious TRAE or G5 were reported. The RP2D was determined to be DL 1. Median PFS was 3.8 months (95% CI 1.9-6.8) and disease control rate was 86.7%.ConclusionThe combination of cabozantinib and FTD/TPI is feasible and tolerable at standard doses with the use of growth factors and showed encouraging clinical activity in refractory mCRC.ClinicaltrialsGOV: NCT04868773.
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- 2024
73. Venous thromboembolism in adolescents and young adults with acute lymphoblastic leukemia treated on a pediatric-inspired regimen
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Shimony, Shai, Raman, Hari S., Flamand, Yael, Keating, Julia, Paolino, Jonathan D., Valtis, Yannis K., Place, Andrew E., Silverman, Lewis B., Sallan, Stephen E., Vrooman, Lynda M., Brunner, Andrew M., Neuberg, Donna S., Galinsky, Ilene, Garcia, Jacqueline S., Winer, Eric S., Wadleigh, Martha, Stone, Richard M., Connors, Jean M., DeAngelo, Daniel J., and Luskin, Marlise R.
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- 2024
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74. The DLEU2/miR-15a/miR-16-1 cluster shapes the immune microenvironment of chronic lymphocytic leukemia
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Zhang, Ronghua, Khare, Priyanka, Banerjee, Priyanka, Ivan, Cristina, Schneider, Sarah, Barbaglio, Federica, Clise-Dwyer, Karen, Jensen, Vanessa Behrana, Thompson, Erika, Mendoza, Marisela, Chiorazzi, Nicholas, Chen, Shih-Shih, Yan, Xiao-Jie Joy, Jain, Nitin, Ghia, Paolo, Caligaris-Cappio, Federico, Mendonsa, Rima, Kasimsetty, Sashi, Swoboda, Ryan, Bayraktar, Recep, Wierda, William, Gandhi, Varsha, Calin, George A., Keating, Michael J., and Bertilaccio, Maria Teresa Sabrina
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- 2024
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75. Balancing the scales: assessing the impact of irrigation and pathogen burden on potato blackleg disease and soil microbial communities
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Keating, Ciara, Kilbride, Elizabeth, Stalham, Mark A., Nellist, Charlotte, Milner, Joel, Humphris, Sonia, Toth, Ian, Mable, Barbara K., and Ijaz, Umer Zeeshan
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- 2024
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76. Enhancing recovery: surgical techniques and rehabilitation strategies after direct anterior hip arthroplasty
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Di Martino, Alberto, Keating, Christopher, Butsick, Michael J., Platano, Daniela, Berti, Lisa, Hunter, Louis N., and Faldini, Cesare
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- 2024
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77. Utilizing technology for diet and exercise change in complex chronic conditions across diverse environments (U-DECIDE): feasibility randomised controlled trial
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Brown, Riley C. C., Keating, Shelley E., Jegatheesan, Dev K., Mayr, Hannah L., Barnett, Amandine, Conley, Marguerite M., Webb, Lindsey, Kelly, Jaimon T., Snoswell, Centaine L., Staudacher, Heidi M., Macdonald, Graeme A., Burton, Nicola W., Coombes, Jeff S., Campbell, Katrina L., Isbel, Nicole M., and Hickman, Ingrid J.
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- 2024
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78. Modelling the nicotine pharmacokinetic profile for e-cigarettes using real time monitoring of consumers’ physiological measurements and mouth level exposure
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Prasad, Krishna, Griffiths, Allen, Agrawal, Kavya, McEwan, Michael, Macci, Flavio, Ghisoni, Marco, Stopher, Matthew, Napleton, Matthew, Strickland, Joel, Keating, David, Whitehead, Thomas, Conduit, Gareth, Murray, Stacey, and Edward, Lauren
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- 2024
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79. The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis
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Murray, Jayne E., Valli, Emanuele, Milazzo, Giorgio, Mayoh, Chelsea, Gifford, Andrew J., Fletcher, Jamie I., Xue, Chengyuan, Jayatilleke, Nisitha, Salehzadeh, Firoozeh, Gamble, Laura D., Rouaen, Jourdin R. C., Carter, Daniel R., Forgham, Helen, Sekyere, Eric O., Keating, Joanna, Eden, Georgina, Allan, Sophie, Alfred, Stephanie, Kusuma, Frances K., Clark, Ashleigh, Webber, Hannah, Russell, Amanda J., de Weck, Antoine, Kile, Benjamin T., Santulli, Martina, De Rosa, Piergiuseppe, Fleuren, Emmy D. G., Gao, Weiman, Wilkinson-White, Lorna, Low, Jason K. K., Mackay, Joel P., Marshall, Glenn M., Hilton, Douglas J., Giorgi, Federico M., Koster, Jan, Perini, Giovanni, Haber, Michelle, and Norris, Murray D.
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- 2024
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80. Content validation of the National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy Lymphoma Symptom Index-18 (NFLymSI-18) in indolent B-cell non-Hodgkin’s lymphoma
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Hurt, Courtney N., Kaiser, Karen, Shaunfield, Sara, Webster, Kimberly A., Keating, Karen, Boyken, Lara, Duffey, Sara, Garcia, Jessica, and Cella, David
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- 2024
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81. Developing a fit-for-purpose composite symptom score as a symptom burden endpoint for clinical trials in patients with malignant pleural mesothelioma
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Cleeland, Charles S., Keating, Karen N., Cuffel, Brian, Elbi, Cem, Siegel, Jonathan M., Gerlinger, Christoph, Symonds, Tara, Sloan, Jeff A., Dueck, Amylou C., Bottomley, Andrew, Wang, Xin Shelley, Williams, Loretta A., and Mendoza, Tito R.
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- 2024
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82. The impact of low pressure pneumoperitoneum in robotic assisted radical prostatectomy II: a prospective, randomized, double blinded trial
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Keating, Kevin, Holdren, Charla, Eames, Richard, Pulford, Christopher, O’Pry, Emiley, Peifer, David, Rohloff, Matthew, Fletcher, Jeffery, and Maatman, Thomas J.
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- 2024
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83. The accuracy of prehospital triage decisions in English trauma networks – a case-cohort study
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Fuller, G., Baird, J., Keating, S., Miller, J., Pilbery, R., Kean, N., McKnee, K., Turner, J., Lecky, F., Edwards, A., Rosser, A., Fothergill, R., Black, S., Bell, F., Smyth, M., Smith, JE., Perkins, GD., Herbert, E., Walters, S., and Cooper, C.
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- 2024
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84. Quantitative assessment of H&E staining for pathology: development and clinical evaluation of a novel system
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Dunn, Catriona, Brettle, David, Cockroft, Martin, Keating, Elizabeth, Revie, Craig, and Treanor, Darren
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- 2024
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85. A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration
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San Gil, Rebecca, Pascovici, Dana, Venturato, Juliana, Brown-Wright, Heledd, Mehta, Prachi, Madrid San Martin, Lidia, Wu, Jemma, Luan, Wei, Chui, Yi Kit, Bademosi, Adekunle T., Swaminathan, Shilpa, Naidoo, Serey, Berning, Britt A., Wright, Amanda L., Keating, Sean S., Curtis, Maurice A., Faull, Richard L. M., Lee, John D., Ngo, Shyuan T., Lee, Albert, Morsch, Marco, Chung, Roger S., Scotter, Emma, Lisowski, Leszek, Mirzaei, Mehdi, and Walker, Adam K.
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- 2024
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86. Implementation of type 1 diabetes genetic risk screening in children in diverse communities: the Virginia PrIMeD project
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Guertin, Kristin A., Repaske, David R., Taylor, Julia F., Williams, Eli S., Onengut-Gumuscu, Suna, Chen, Wei-Min, Boggs, Sarah R., Yu, Liping, Allen, Luke, Botteon, Lacey, Daniel, Louis, Keating, Katherine G., Labergerie, Mika K., Lienhart, Tyler S., Gonzalez-Mejia, Jorge A., Starnowski, Matt J., and Rich, Stephen S.
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- 2024
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87. Effectiveness of a telehealth-delivered clinician-supported exercise and weight loss program for hip osteoarthritis – protocol for the Better Hip randomised controlled trial
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Bennell, Kim L., Keating, Catherine, Lawford, Belinda, Graham, Bridget, Hall, Michelle, Simpson, Julie A., McManus, Fiona, Hosking, Brinley, Sumithran, Priya, Harris, Anthony, Woode, Maame Esi, Francis, Jill J., Marlow, Jennifer, Poh, Sharon, and Hinman, Rana S.
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- 2024
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88. Evaluation of a multi-component early warning system for pastoralist populations in Doolo zone, Ethiopia: mixed-methods study
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Baertlein, Luke, Dubad, Bashir Ali, Sahelie, Birhanu, Damulak, Istifanus Chindong, Osman, Mohammed, Stringer, Beverley, Bestman, Agatha, Kuehne, Anna, van Boetzelaer, Elburg, and Keating, Patrick
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- 2024
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89. Gut microbial ecology and exposome of a healthy Pakistani cohort
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Gul, Farzana, Herrema, Hilde, Davids, Mark, Keating, Ciara, Nasir, Arshan, Ijaz, Umer Zeeshan, and Javed, Sundus
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- 2024
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90. Venous thromboembolism in adolescents and young adults with acute lymphoblastic leukemia treated on a pediatric-inspired regimen
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Shai Shimony, Hari S. Raman, Yael Flamand, Julia Keating, Jonathan D. Paolino, Yannis K. Valtis, Andrew E. Place, Lewis B. Silverman, Stephen E. Sallan, Lynda M. Vrooman, Andrew M. Brunner, Donna S. Neuberg, Ilene Galinsky, Jacqueline S. Garcia, Eric S. Winer, Martha Wadleigh, Richard M. Stone, Jean M. Connors, Daniel J. DeAngelo, and Marlise R. Luskin
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Asparaginase (ASP)-containing regimens for acute lymphoblastic leukemia (ALL) are associated with venous thromboembolism (VTE). We evaluated the prevalence, risk factors, role of prophylaxis and clinical impact of VTE among adolescents and young adult (AYA) patients (15–50 years) treated on Dana-Farber Cancer Institute (DFCI) ALL protocols. The 1- and 2-year cumulative incidence of VTE were 31.9% (95% CI: 27.0%, 36.9%) and 33.5% (95% CI: 28.5%, 38.5%) respectively, with most events occurring during ASP-based consolidation phase (68.6%). VTE was more frequent in patients with overweight/obese vs. normal BMI (39.2% vs. 29.0%, p = 0.048). In a 1-year landmark analysis, the 4-year overall survival was 91.5%, without difference between patients with vs. without VTE (93.8% vs. 90.0%, p = 0.93). Relapse and non-relapse mortality rates were also similar. Among patients treated at Dana-Farber/Harvard Cancer Center, cerebral sinus vein thrombosis occurred in 3.6% of patients (8.5% of VTE events) in comparison to pulmonary embolism (32.9%) and deep vein thromboses (58.6%, 24.4% line-associated). In a Cox regression model for VTE free-time, elevated BMI was associated with shorter VTE free-time (HR 1.94 [95% CI 1.13-3.35], p = 0.018), while low molecular weight heparin (LMWH) prophylaxis as time-varying covariate was not. In conclusion, we found that VTE was frequent in AYAs treated on DFCI ALL protocols but did not impact survival outcomes. Overweight/obese BMI increased risk for VTE.
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- 2024
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91. The DLEU2/miR-15a/miR-16-1 cluster shapes the immune microenvironment of chronic lymphocytic leukemia
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Ronghua Zhang, Priyanka Khare, Priyanka Banerjee, Cristina Ivan, Sarah Schneider, Federica Barbaglio, Karen Clise-Dwyer, Vanessa Behrana Jensen, Erika Thompson, Marisela Mendoza, Nicholas Chiorazzi, Shih-Shih Chen, Xiao-Jie Joy Yan, Nitin Jain, Paolo Ghia, Federico Caligaris-Cappio, Rima Mendonsa, Sashi Kasimsetty, Ryan Swoboda, Recep Bayraktar, William Wierda, Varsha Gandhi, George A. Calin, Michael J. Keating, and Maria Teresa Sabrina Bertilaccio
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract The development and progression of chronic lymphocytic leukemia (CLL) depend on genetic abnormalities and on the immunosuppressive microenvironment. We have explored the possibility that genetic drivers might be responsible for the immune cell dysregulation that shapes the protumor microenvironment. We performed a transcriptome analysis of coding and non-coding RNAs (ncRNAs) during leukemia progression in the Rag2−/−γc −/− MEC1-based xenotransplantation model. The DLEU2/miR-16 locus was found downmodulated in monocytes/macrophages of leukemic mice. To validate the role of this cluster in the tumor immune microenvironment, we generated a mouse model that simultaneously mimics the overexpression of hTCL1 and the germline deletion of the minimal deleted region (MDR) encoding the DLEU2/miR-15a/miR-16-1 cluster. This model provides an innovative and faster CLL system where monocyte differentiation and macrophage polarization are exacerbated, and T-cells are dysfunctional. MDR deletion inversely correlates with the levels of predicted target proteins including BCL2 and PD1/PD-L1 on murine CLL cells and immune cells. The inverse correlation of miR-15a/miR-16-1 with target proteins has been confirmed on patient-derived immune cells. Forced expression of miR-16-1 interferes with monocyte differentiation into tumor-associated macrophages, indicating that selected ncRNAs drive the protumor phenotype of non-malignant immune cells.
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- 2024
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92. Balancing the scales: assessing the impact of irrigation and pathogen burden on potato blackleg disease and soil microbial communities
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Ciara Keating, Elizabeth Kilbride, Mark A. Stalham, Charlotte Nellist, Joel Milner, Sonia Humphris, Ian Toth, Barbara K. Mable, and Umer Zeeshan Ijaz
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Potato blackleg ,Common scab disease ,Soil microbial communities ,Potato crop health ,Pectobacterium ,Bioinformatics ,Microbial ecology ,QR100-130 - Abstract
Abstract Background Understanding the interaction between environmental conditions, crop yields, and soil health is crucial for sustainable agriculture in a changing climate. Management practices to limit disease are a balancing act. For example, in potato production, dry conditions favour common scab (Streptomyces spp.) and wet conditions favour blackleg disease (Pectobacterium spp.). The exact mechanisms involved and how these link to changes in the soil microbiome are unclear. Our objectives were to test how irrigation management and bacterial pathogen load in potato seed stocks impact: (i) crop yields; (ii) disease development (blackleg or common scab); and (iii) soil microbial community dynamics. Methods We used stocks of seed potatoes with varying natural levels of Pectobacterium (Jelly [high load], Jelly [low load] and Estima [Zero – no Pectobacterium]). Stocks were grown under four irrigation regimes that differed in the timing and level of watering. The soil microbial communities were profiled using amplicon sequencing at 50% plant emergence and at harvest. Generalised linear latent variable models and an annotation-free mathematical framework approach (ensemble quotient analysis) were then used to show the interacting microbes with irrigation regime and Pectobacterium pathogen levels. Results Irrigation increased blackleg symptoms in the plots planted with stocks with low and high levels of Pectobacterium (22–34%) but not in the zero stock (2–6%). However, withholding irrigation increased common scab symptoms (2–5%) and reduced crop yields. Irrigation did not impact the composition of the soil microbiome, but planting stock with a high Pectobacterium burden resulted in an increased abundance of Planctomycetota, Anaerolinea and Acidobacteria species within the microbiome. Ensemble quotient analysis highlighted the Anaerolinea taxa were highly associated with high levels of Pectobacterium in the seed stock and blackleg symptoms in the field. Conclusions We conclude that planting seed stocks with a high Pectobacterium burden alters the abundance of specific microbial species within the soil microbiome and suggest that managing pathogen load in seed stocks could substantially affect soil communities, affecting crop health and productivity. Video Abstract
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- 2024
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93. Sébastien Brémond's Paratexts: Authorship, Genre, and Masculinity
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Keating, Erin
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- 2024
94. Asymptotics of Bounded Lecture-Hall Tableaux
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Keating, David, Li, Zhongyang, and Prause, Istvan
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Mathematics - Probability ,Mathematics - Combinatorics - Abstract
We study the asymptotics of bounded lecture hall tableaux. Limit shapes form when the bounds of the lecture hall tableaux go to infinity linearly in the lengths of the partitions describing the large-scale shapes of these tableaux. We prove Conjecture 6.1 in \cite{SKN21}, stating that the slopes of the rescaled height functions in the scaling limit satisfy a complex Burgers equation. We also show that the fluctuations of the unrescaled height functions converge to the Gaussian free field. The proof is based on new construction and analysis of Schur generating functions for the lecture hall tableaux, whose corresponding particle configurations do not form a Gelfand-Tsetlin scheme; and the corresponding dimer models are not doubly periodic.
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- 2023
95. Unveiling Dark Matter free-streaming at the smallest scales with high redshift Lyman-alpha forest
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Iršič, Vid, Viel, Matteo, Haehnelt, Martin G., Bolton, James S., Molaro, Margherita, Puchwein, Ewald, Boera, Elisa, Becker, George D., Gaikwad, Prakash, Keating, Laura C., and Kulkarni, Girish
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Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
This study introduces novel constraints on the free-streaming of thermal relic warm dark matter (WDM) from Lyman-$\alpha$ forest flux power spectra. Our analysis utilises a high-resolution, high-redshift sample of quasar spectra observed using the HIRES and UVES spectrographs ($z=4.2-5.0$). We employ a Bayesian inference framework and a simulation-based likelihood that encompasses various parameters including the free-streaming of dark matter, cosmological parameters, the thermal history of the intergalactic medium, and inhomogeneous reionization, to establish lower limits on the mass of a thermal relic WDM particle of $5.7\;\mathrm{keV}$ (at 95\% C.L.). This result surpasses previous limits from the Lyman-$\alpha$ forest through reduction of the measured uncertainties due to a larger statistical sample and by measuring clustering to smaller scales ($k_{\rm max}=0.2\;\mathrm{km^{-1}\,s}$). The approximately two-fold improvement due to the expanded statistical sample suggests that the effectiveness of Lyman-$\alpha$ forest constraints on WDM models at high redshifts are limited by the availability of high-quality quasar spectra. Restricting the analysis to comparable scales and thermal history priors as in prior studies ($k_{\rm max}<0.1\;\mathrm{km^{-1}\,s}$) lowers the bound on the WDM mass to $4.1\;\mathrm{keV}$. As the precision of the measurements increases, it becomes crucial to examine the instrumental and modelling systematics. On the modelling front, we argue that the impact of the thermal history uncertainty on the WDM particle mass constraint has diminished due to improved independent observations. At the smallest scales, the primary source of modeling systematic arises from the structure in the peculiar velocity of the intergalactic medium and inhomogeneous reionization., Comment: 22 pages, 14 figures, 2 tables; published in PRD on Feb 8 2024
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- 2023
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96. Measurements of the $z > 5$ Lyman-$\alpha$ forest flux auto-correlation functions from the extended XQR-30 data set
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Wolfson, Molly, Hennawi, Joseph F., Bosman, Sarah E. I., Davies, Frederick B., Lukić, Zarija, Becker, George D., Chen, Huanqing, Cupani, Guido, D'Odorico, Valentina, Eilers, Anna-Christina, Haehnelt, Martin G., Keating, Laura C., Kulkarni, Girish, Lai, Samuel, Mesinger, Andrei, Walter, Fabian, and Zhu, Yongda
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
Recently, the Lyman-$\alpha$ (Ly$\alpha$) forest flux auto-correlation function has been shown to be sensitive to the mean free path of hydrogen-ionizing photons, $\lambda_{\text{mfp}}$, for simulations at $z \geq 5.4$. Measuring $\lambda_{\text{mfp}}$ at these redshifts will give vital information on the ending of reionization. Here we present the first observational measurements of the Ly$\alpha$ forest flux auto-correlation functions in ten redshift bins from $5.1 \leq z \leq 6.0$. We use a sample of 35 quasar sightlines at $z > 5.7$ from the extended XQR-30 data set, this data has signal-to-noise ratios of $> 20$ per spectral pixel. We carefully account for systematic errors in continuum reconstruction, instrumentation, and contamination by damped Ly$\alpha$ systems. With these measurements, we introduce software tools to generate auto-correlation function measurements from any simulation. For an initial comparison, we show our auto-correlation measurements with simulation models for recently measured $\lambda_{\text{mfp}}$ values and find good agreements. Further work in modeling and understanding the covariance matrices of the data is necessary to get robust measurements of $\lambda_{\text{mfp}}$ from this data., Comment: 17 pages, 13 figures, submitted to MNRAS
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- 2023
97. The Simons Observatory: A fully remote controlled calibration system with a sparse wire grid for cosmic microwave background telescopes
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Murata, Masaaki, Nakata, Hironobu, Iijima, Kengo, Adachi, Shunsuke, Seino, Yudai, Kiuchi, Kenji, Matsuda, Frederick, Randall, Michael J., Arnold, Kam, Galitzki, Nicholas, Johnson, Bradley R., Keating, Brian, Kusaka, Akito, Lloyd, John B., Seibert, Joseph, Silva-Feaver, Maximiliano, Tajima, Osamu, Terasaki, Tomoki, and Yamada, Kyohei
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
For cosmic microwave background (CMB) polarization observations, calibration of detector polarization angles is essential. We have developed a fully remote controlled calibration system with a sparse wire grid that reflects linearly polarized light along the wire direction. The new feature is a remote-controlled system for regular calibration, which has not been possible in sparse wire grid calibrators in past experiments. The remote control can be achieved by two electric linear actuators that load or unload the sparse wire grid into a position centered on the optical axis of a telescope between the calibration time and CMB observation. Furthermore, the sparse wire grid can be rotated by a motor. A rotary encoder and a gravity sensor are installed on the sparse wire grid to monitor the wire direction. They allow us to achieve detector angle calibration with expected systematic error of $0.08^{\circ}$. The calibration system will be installed in small-aperture telescopes at Simons Observatory.
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- 2023
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98. A search for pulsars around Sgr A* in the first Event Horizon Telescope dataset
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Torne, Pablo, Liu, Kuo, Eatough, Ralph P., Wongphechauxsorn, Jompoj, Cordes, James M., Desvignes, Gregory, De Laurentis, Mariafelicia, Kramer, Michael, Ransom, Scott M., Chatterjee, Shami, Wharton, Robert, Karuppusamy, Ramesh, Blackburn, Lindy, Janssen, Michael, Chan, Chi-kwan, Crew, Geoffrey B., Matthews, Lynn D., Goddi, Ciriaco, Rottmann, Helge, Wagner, Jan, Sanchez, Salvador, Ruiz, Ignacio, Abbate, Federico, Bower, Geoffrey C., Salamanca, Juan J., Gomez-Ruiz, Arturo I., Herrera-Aguilar, Alfredo, Jiang, Wu, Lu, Ru-Sen, Pen, Ue-Li, Raymond, Alexander W., Shao, Lijing, Shen, Zhiqiang, Paubert, Gabriel, Sanchez-Portal, Miguel, Kramer, Carsten, Castillo, Manuel, Navarro, Santiago, John, David, Schuster, Karl-Friedrich, Johnson, Michael D., Rygl, Kazi L. J., Akiyama, Kazunori, Alberdi, Antxon, Alef, Walter, Algaba, Juan Carlos, Anantua, Richard, Asada, Keiichi, Azulay, Rebecca, Bach, Uwe, Baczko, Anne-Kathrin, Ball, David, Balokovic, Mislav, Barrett, John, Bauboeck, Michi, Benson, Bradford A., Bintley, Dan, Blundell, Raymond, Bouman, Katherine L., Boyce, Hope, Bremer, Michael, Brinkerink, Christiaan D., Brissenden, Roger, Britzen, Silke, Broderick, Avery E., Broguiere, Dominique, Bronzwaer, Thomas, Bustamante, Sandra, Byun, Do-Young, Carlstrom, John E., Ceccobello, Chiara, Chael, Andrew, Chang, Dominic O., Chatterjee, Koushik, Chen, Ming-Tang, Chen, Yongjun, Cheng, Xiaopeng, Cho, Ilje, Christian, Pierre, Conroy, Nicholas S., Conway, John E., Crawford, Thomas M., Cruz-Osorio, Alejandro, Cui, Yuzhu, Dahale, Rohan, Davelaar, Jordy, Deane, Roger, Dempsey, Jessica, Dexter, Jason, Dhruv, Vedant, Doeleman, Sheperd S., Dougal, Sean, Dzib, Sergio A., Emami, Razieh, Falcke, Heino, Farah, Joseph, Fish, Vincent L., Fomalont, Ed, Ford, H. Alyson, Foschi, Marianna, Fraga-Encinas, Raquel, Freeman, William T., Friberg, Per, Fromm, Christian M., Fuentes, Antonio, Galison, Peter, Gammie, Charles F., Garcia, Roberto, Gentaz, Olivier, Georgiev, Boris, Gold, Roman, Gomez, Jose L., Gu, Minfeng, Gurwell, Mark, Hada, Kazuhiro, Haggard, Daryl, Haworth, Kari, Hecht, Michael H., Hesper, Ronald, Heumann, Dirk, Ho, Luis C., Ho, Paul, Honma, Mareki, Huang, Chih-Wei L., Huang, Lei, Hughes, David H., Ikeda, Shiro, Impellizzeri, C. M. Violette, Inoue, Makoto, Issaoun, Sara, James, David J., Jannuzi, Buell T., Jeter, Britton, Jimenez-Rosales, Alejandra, Jorstad, Svetlana, Joshi, Abhishek V., Jung, Taehyun, Karami, Mansour, Kawashima, Tomohisa, Keating, Garrett K., Kettenis, Mark, Kim, Dong-Jin, Kim, Jae-Young, Kim, Jongsoo, Kim, Junhan, Kino, Motoki, Koay, Jun Yi, Kocherlakota, Prashant, Kofuji, Yutaro, Koyama, Shoko, Krichbaum, Thomas P., Kuo, Cheng-Yu, La Bella, Noemi, Lauer, Tod R., Lee, Daeyoung, Lee, Sang-Sung, Leung, Po Kin, Levis, Aviad, Li, Zhiyuan, Lico, Rocco, Lindahl, Greg, Lindqvist, Michael, Lisakov, Mikhail, Liu, Jun, Liuzzo, Elisabetta, Lo, Wen-Ping, Lobanov, Andrei P., Loinard, Laurent, Lonsdale, Colin J., MacDonald, Nicholas R., Mao, Jirong, Marchili, Nicola, Markoff, Sera, Marrone, Daniel P., Marscher, Alan P., Marti-Vidal, Ivan, Matsushita, Satoki, Medeiros, Lia, Menten, Karl M., Michalik, Daniel, Mizuno, Izumi, Mizuno, Yosuke, Moran, James M., Moriyama, Kotaro, Moscibrodzka, Monika, Muller, Cornelia, Muller, Hendrik, Mus, Alejandro, Musoke, Gibwa, Myserlis, Ioannis, Nadolski, Andrew, Nagai, Hiroshi, Nagar, Neil M., Nakamura, Masanori, Narayan, Ramesh, Narayanan, Gopal, Natarajan, Iniyan, Nathanail, Antonios, Neilsen, Joey, Neri, Roberto, Ni, Chunchong, Noutsos, Aristeidis, Nowak, Michael A., Oh, Junghwan, Okino, Hiroki, Olivares, Hector, Ortiz-Leon, Gisela N., Oyama, Tomoaki, Ozel, Feryal, Palumbo, Daniel C. M., Paraschos, Georgios Filippos, Park, Jongho, Parsons, Harriet, Patel, Nimesh, Pesce, Dominic W., Pietu, Vincent, Plambeck, Richard, PopStefanija, Aleksandar, Porth, Oliver, Potzl, Felix M., Prather, Ben, Preciado-Lopez, Jorge A., Psaltis, Dimitrios, Pu, Hung-Yi, Ramakrishnan, Venkatessh, Rao, Ramprasad, Rawlings, Mark G., Rezzolla, Luciano, Ricarte, Angelo, Ripperda, Bart, Roelofs, Freek, Rogers, Alan, Ros, Eduardo, Romero-Cañizales, Cristina, Roshanineshat, Arash, Roy, Alan L., Ruszczyk, Chet, Sanchez-Arguelles, David, Sasada, Mahito, Satapathy, Kaushik, Savolainen, Tuomas, Schloerb, F. Peter, Schonfeld, Jonathan, Small, Des, Sohn, Bong Won, SooHoo, Jason, Souccar, Kamal, Sun, He, Tetarenko, Alexandra J., Tiede, Paul, Tilanus, Remo P. J., Titus, Michael, Toscano, Teresa, Traianou, Efthalia, Trent, Tyler, Trippe, Sascha, Turk, Matthew, van Bemmel, Ilse, van Langevelde, Huib Jan, van Rossum, Daniel R., Vos, Jesse, Ward-Thompson, Derek, Wardle, John, Weintroub, Jonathan, Wex, Norbert, Wielgus, Maciek, Wiik, Kaj, Witzel, Gunther, Wondrak, Michael F., Wong, George N., Wu, Qingwen, Yadlapalli, Nitika, Yamaguchi, Paul, Yfantis, Aristomenis, Yoon, Doosoo, Young, Andre, Young, Ken, Younsi, Ziri, Yu, Wei, Yuan, Feng, Yuan, Ye-Fei, Zensus, J. Anton, Zhang, Shuo, Zhao, Guang-Yao, and Zhao, Shan-Shan
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Event Horizon Telescope (EHT) observed in 2017 the supermassive black hole at the center of the Milky Way, Sagittarius A* (Sgr A*), at a frequency of 228.1 GHz ($\lambda$=1.3 mm). The fundamental physics tests that even a single pulsar orbiting Sgr A* would enable motivate searching for pulsars in EHT datasets. The high observing frequency means that pulsars - which typically exhibit steep emission spectra - are expected to be very faint. However, it also negates pulse scattering, an effect that could hinder pulsar detections in the Galactic Center. Additionally, magnetars or a secondary inverse Compton emission could be stronger at millimeter wavelengths than at lower frequencies. We present a search for pulsars close to Sgr A* using the data from the three most-sensitive stations in the EHT 2017 campaign: the Atacama Large Millimeter/submillimeter Array, the Large Millimeter Telescope and the IRAM 30 m Telescope. We apply three detection methods based on Fourier-domain analysis, the Fast-Folding-Algorithm and single pulse search targeting both pulsars and burst-like transient emission; using the simultaneity of the observations to confirm potential candidates. No new pulsars or significant bursts were found. Being the first pulsar search ever carried out at such high radio frequencies, we detail our analysis methods and give a detailed estimation of the sensitivity of the search. We conclude that the EHT 2017 observations are only sensitive to a small fraction ($\lesssim$2.2%) of the pulsars that may exist close to Sgr A*, motivating further searches for fainter pulsars in the region., Comment: 33 pages, 7 figures, 6 Tables. Accepted for publication in ApJ
- Published
- 2023
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