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388 results on '"Kawata, Kazuhito"'

51. A Case of Adrenocortical Carcinoma With a Favorable Tumor Control by Radiofrequency Ablation for Liver Metastasis.

Author: Kitsugi, Kensuke, Kawata, Kazuhito, Kakizawa, Keisuke, and Noritake, Hidenao
Abstract: A 57-year-old woman was diagnosed with adrenocortical carcinoma. Following the adrenalectomy, she underwent adjuvant radiation and mitotane therapy; however, liver metastases were observed. Repeated radiofrequency ablation (RFA) was performed for liver metastases. In addition, a multidisciplinary approach combining systemic chemotherapy, radiotherapy, and surgery was used for lung and distant lymph node metastases that arose during the course of treatment. Notably, 49 months have passed since the adrenalectomy and 36 months since the recurrence of the liver metastases, and the patient remains on multidisciplinary therapy. Thus, RFA for liver metastasis of adrenocortical carcinoma may be an effective component of a multidisciplinary treatment. [ABSTRACT FROM AUTHOR]
Published: 2023
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52. Emergence of anti-mitochondrial M2 antibody in patient with angioimmunoblastic T-cell lymphoma

Author: Wakabayashi, Shun-ichi, Kimura, Takefumi, Tanaka, Naoki, Joshita, Satoru, Kawata, Kazuhito, Umemura, Takeji, Hiroshima, Yuki, Mori, Hiromitsu, Kobayashi, Hikaru, Wada, Shuichi, and Tanaka, Eiji
Published: 2018
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53. Phosphatidylcholine in bile‐derived small extracellular vesicles as a novel biomarker of cholangiocarcinoma

Author: Muraki, Ryuta, primary, Morita, Yoshifumi, additional, Ida, Shinya, additional, Kitajima, Ryo, additional, Furuhashi, Satoru, additional, Takeda, Makoto, additional, Kikuchi, Hirotoshi, additional, Hiramatsu, Yoshihiro, additional, Takanashi, Yusuke, additional, Hamaya, Yasushi, additional, Sugimoto, Ken, additional, Ito, Jun, additional, Kawata, Kazuhito, additional, Kawasaki, Hideya, additional, Sato, Tomohito, additional, Kahyo, Tomoaki, additional, Setou, Mitsutoshi, additional, and Takeuchi, Hiroya, additional
Published: 2023
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54. Hepatic Angiosarcoma with Peliosis Hepatis

Author: Kitsugi, Kensuke, primary, Kawata, Kazuhito, additional, Matsumoto, Moe, additional, Umemura, Masahiro, additional, Hanaoka, Tomohiko, additional, Yamashita, Maho, additional, Takatori, Shingo, additional, Ito, Jun, additional, Ohta, Kazuyoshi, additional, Chida, Takeshi, additional, Noritake, Hidenao, additional, and Suda, Takafumi, additional
Published: 2023
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55. Association of PPI and antibiotics with the clinical outcomes of HCC patients receiving atezolizumab and bevacizumab: A multicenter analysis

Author: Hatanaka, Takeshi, primary, Kakizaki, Satoru, additional, Hiraoka, Atsushi, additional, Tada, Toshifumi, additional, Hirooka, Masashi, additional, Kariyama, Kazuya, additional, Tani, Joji, additional, Atsukawa, Masanori, additional, Takaguchi, Koichi, additional, Itobayashi, Ei, additional, Fukunishi, Shinya, additional, Tsuji, Kunihiko, additional, Ishikawa, Toru, additional, Tajiri, Kazuto, additional, Ochi, Hironori, additional, Yasuda, Satoshi, additional, Toyoda, Hidenori, additional, Ogawa, Chikara, additional, Nishimura, Takashi, additional, Shimada, Noritomo, additional, Kawata, Kazuhito, additional, Kosaka, Hisashi, additional, Naganuma, Atsushi, additional, Yata, Yutaka, additional, Tanaka, Takaaki, additional, Ohama, Hideko, additional, Tada, Fujimasa, additional, Nouso, Kazuhiro, additional, Morishita, Asahiro, additional, Tsutsui, Akemi, additional, Nagano, Takuya, additional, Itokawa, Norio, additional, Okubo, Tomomi, additional, Arai, Taeang, additional, Imai, Michitaka, additional, Koizumi, Yohei, additional, Nakamura, Shinichiro, additional, Kaibori, Masaki, additional, Iijima, Hiroko, additional, Hiasa, Yoichi, additional, and Kumada, Takashi, additional
Published: 2023
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56. Gallbladder perforation following peroral cholangioscopy‐guided lithotripsy: A case report

Author: Kaneko, Junichi, primary, Watahiki, Moeka, additional, Jindo, Osamu, additional, Matsumoto, Keigo, additional, Kosugi, Toshikatsu, additional, Kusama, Daisuke, additional, Tamakoshi, Hiroki, additional, Niwa, Tomoyuki, additional, Takeshita, Yu, additional, Takinami, Masaki, additional, Kiuchi, Ryota, additional, Tsuji, Atsushi, additional, Nishino, Masafumi, additional, Takahashi, Yurimi, additional, Sasada, Yuzo, additional, Kawata, Kazuhito, additional, Yamada, Takanori, additional, and Sakaguchi, Takanori, additional
Published: 2023
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57. Rifaximin Improves Liver Functional Reserve by Regulating Systemic Inflammation

Author: Kitsugi, Kensuke, primary, Kawata, Kazuhito, additional, Noritake, Hidenao, additional, Chida, Takeshi, additional, Ohta, Kazuyoshi, additional, Ito, Jun, additional, Takatori, Shingo, additional, Yamashita, Maho, additional, Hanaoka, Tomohiko, additional, Umemura, Masahiro, additional, Matsumoto, Moe, additional, and Suda, Takafumi, additional
Published: 2023
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58. Identification of clinical phenotypes associated with poor prognosis in patients with nonalcoholic fatty liver disease via unsupervised machine learning.

Author: Ito, Takanori, Morooka, Hikaru, Takahashi, Hirokazu, Fujii, Hideki, Iwaki, Michihiro, Hayashi, Hideki, Toyoda, Hidenori, Oeda, Satoshi, Hyogo, Hideyuki, Kawanaka, Miwa, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Tsutsumi, Tsubasa, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, and Araki, Asuka
Subjects: FATTY liver, NON-alcoholic fatty liver disease, MACHINE learning, GAUSSIAN mixture models, BODY mass index, MEDIAN (Mathematics)
Abstract: Background and Aims: Both fibrosis status and body weight are important for assessing prognosis in nonalcoholic fatty liver disease (NAFLD). The aim of this study was to identify population clusters for specific clinical outcomes based on fibrosis‐4 (FIB‐4) index and body mass index (BMI) using an unsupervised machine learning method. Methods: We conducted a multicenter study of 1335 biopsy‐proven NAFLD patients from Japan. Using the Gaussian mixture model to divide the cohort into clusters based on FIB‐4 index and BMI, we investigated prognosis for these clusters. Results: The cohort consisted of 223 cases (16.0%) with advanced fibrosis (F3–4) as assessed from liver biopsy. Median values of BMI and FIB‐4 index were 27.3 kg/m2 and 1.67. The patients were divided into four clusters by Bayesian information criterion, and all‐cause mortality was highest in cluster d, followed by cluster b (P = 0.001). Regarding the characteristics of each cluster, clusters d and b presented a high FIB‐4 index (median 5.23 and 2.23), cluster a presented the lowest FIB‐4 index (median 0.78), and cluster c was associated with moderate FIB‐4 level (median 1.30) and highest BMI (median 34.3 kg/m2). Clusters a and c had lower mortality rates than clusters b and d. However, all‐cause of death in clusters a and c was unrelated to liver disease. Conclusions: Our clustering approach found that the FIB‐4 index is an important predictor of mortality in NAFLD patients regardless of BMI. Additionally, non‐liver‐related diseases were identified as the causes of death in NAFLD patients with low FIB‐4 index. [ABSTRACT FROM AUTHOR]
Published: 2023
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59. A multicenter, retrospective, cohort study shows platelet counts predict HCC development in patients with NAFLD

Author: Fujii, Hideki, primary, Fujii, Makoto, additional, Iwaki, Michihiro, additional, Hayashi, Hideki, additional, Toyoda, Hidenori, additional, Oeda, Satoshi, additional, Hyogo, Hideyuki, additional, Kawanaka, Miwa, additional, Morishita, Asahiro, additional, Munekage, Kensuke, additional, Kawata, Kazuhito, additional, Tsutsumi, Tsubasa, additional, Sawada, Koji, additional, Maeshiro, Tatsuji, additional, Tobita, Hiroshi, additional, Yoshida, Yuichi, additional, Naito, Masafumi, additional, Araki, Asuka, additional, Arakaki, Shingo, additional, Kawaguchi, Takumi, additional, Noritake, Hidenao, additional, Ono, Masafumi, additional, Masaki, Tsutomu, additional, Yasuda, Satoshi, additional, Tomita, Eiichi, additional, Yoneda, Masato, additional, Kawada, Norifumi, additional, Tokushige, Akihiro, additional, Kamada, Yoshihiro, additional, Takahashi, Hirokazu, additional, Ueda, Shinichiro, additional, Aishima, Shinichi, additional, Sumida, Yoshio, additional, Nakajima, Atsushi, additional, and Okanoue, Takeshi, additional
Published: 2023
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60. Role of the prognostic nutritional index in predicting survival in advanced hepatocellular carcinoma treated with atezolizumab plus bevacizumab

Author: Rimini, Margherita, primary, Persano, Mara, additional, Tada, Toshifumi, additional, Suda, Goki, additional, Shimose, Shigeo, additional, Kudo, Masatoshi, additional, Cheon, Jaekyung, additional, Finkelmeier, Fabian, additional, Lim, Ho Yeong, additional, Presa Ramos, José, additional, Masi, Gianluca, additional, Yoo, Changhoon, additional, Lonardi, Sara, additional, Stefanini, Bernardo, additional, Kumada, Takashi, additional, Sakamoto, Naoya, additional, Iwamoto, Hideki, additional, Aoki, Tomoko, additional, Chon, Hong Jae, additional, Himmelsbach, Vera, additional, Montes, Margarida, additional, Vivaldi, Caterina, additional, Soldà, Caterina, additional, Hiraoka, Atsushi, additional, Sho, Takuya, additional, Niizeki, Takashi, additional, Nishida, Naoshi, additional, Steup, Christoph, additional, Hirooka, Masashi, additional, Kariyama, Kazuya, additional, Tani, Joji, additional, Atsukawa, Masanori, additional, Takaguchi, Koichi, additional, Itobayashi, Ei, additional, Fukunishi, Shinya, additional, Tsuji, Kunihiko, additional, Ishikawa, Toru, additional, Tajiri, Kazuto, additional, Ochi, Hironori, additional, Yasuda, Satoshi, additional, Toyoda, Hidenori, additional, Ogawa, Chikara, additional, Nishimura, Takashi, additional, Hatanaka, Takeshi, additional, Kakizaki, Satoru, additional, Shimada, Noritomo, additional, Kawata, Kazuhito, additional, Tada, Fujimasa, additional, Ohama, Hideko, additional, Nouso, Kazuhiro, additional, Morishita, Asahiro, additional, Tsutsui, Akemi, additional, Nagano, Takuya, additional, Itokawa, Norio, additional, Okubo, Tomomi, additional, Arai, Taeang, additional, Imai, Michitaka, additional, Kosaka, Hisashi, additional, Naganuma, Atsushi, additional, Koizumi, Yohei, additional, Nakamura, Shinichiro, additional, Kaibori, Masaki, additional, Iijima, Hiroko, additional, Hiasa, Yoichi, additional, Burgio, Valentina, additional, Della Corte, Angelo, additional, Ratti, Francesca, additional, De Cobelli, Francesco, additional, Aldrighetti, Luca, additional, Scartozzi, Mario, additional, Cascinu, Stefano, additional, and Casadei-Gardini, Andrea, additional
Published: 2023
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61. Adverse events as potential predictive factors of therapeutic activity in patients with unresectable hepatocellular carcinoma treated with atezolizumab plus bevacizumab

Author: Tada, Toshifumi, primary, Kumada, Takashi, additional, Hiraoka, Atsushi, additional, Hirooka, Masashi, additional, Kariyama, Kazuya, additional, Tani, Joji, additional, Atsukawa, Masanori, additional, Takaguchi, Koichi, additional, Itobayashi, Ei, additional, Fukunishi, Shinya, additional, Tsuji, Kunihiko, additional, Ishikawa, Toru, additional, Tajiri, Kazuto, additional, Ochi, Hironori, additional, Yasuda, Satoshi, additional, Toyoda, Hidenori, additional, Ogawa, Chikara, additional, Nishimura, Takashi, additional, Hatanaka, Takeshi, additional, Kakizaki, Satoru, additional, Shimada, Noritomo, additional, Kawata, Kazuhito, additional, Tada, Fujimasa, additional, Ohama, Hideko, additional, Nouso, Kazuhiro, additional, Morishita, Asahiro, additional, Tsutsui, Akemi, additional, Nagano, Takuya, additional, Itokawa, Norio, additional, Okubo, Tomomi, additional, Arai, Taeang, additional, Imai, Michitaka, additional, Kosaka, Hisashi, additional, Naganuma, Atsushi, additional, Koizumi, Yohei, additional, Nakamura, Shinichiro, additional, Kaibori, Masaki, additional, Iijima, Hiroko, additional, and Hiasa, Yoichi, additional
Published: 2022
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62. Clinical outcomes with atezolizumab plus bevacizumab or lenvatinib in patients with hepatocellular carcinoma: a multicenter real-world study

Author: Persano, Mara, primary, Rimini, Margherita, additional, Tada, Toshifumi, additional, Suda, Goki, additional, Shimose, Shigeo, additional, Kudo, Masatoshi, additional, Cheon, Jaekyung, additional, Finkelmeier, Fabian, additional, Lim, Ho Yeong, additional, Rimassa, Lorenza, additional, Presa, José, additional, Masi, Gianluca, additional, Yoo, Changhoon, additional, Lonardi, Sara, additional, Tovoli, Francesco, additional, Kumada, Takashi, additional, Sakamoto, Naoya, additional, Iwamoto, Hideki, additional, Aoki, Tomoko, additional, Chon, Hong Jae, additional, Himmelsbach, Vera, additional, Pressiani, Tiziana, additional, Kawaguchi, Takumi, additional, Montes, Margarida, additional, Vivaldi, Caterina, additional, Soldà, Caterina, additional, Piscaglia, Fabio, additional, Hiraoka, Atsushi, additional, Sho, Takuya, additional, Niizeki, Takashi, additional, Nishida, Naoshi, additional, Steup, Christoph, additional, Iavarone, Massimo, additional, Di Costanzo, Giovanni, additional, Marra, Fabio, additional, Scartozzi, Mario, additional, Tamburini, Emiliano, additional, Cabibbo, Giuseppe, additional, Foschi, Francesco Giuseppe, additional, Silletta, Marianna, additional, Hirooka, Masashi, additional, Kariyama, Kazuya, additional, Tani, Joji, additional, Atsukawa, Masanori, additional, Takaguchi, Koichi, additional, Itobayashi, Ei, additional, Fukunishi, Shinya, additional, Tsuji, Kunihiko, additional, Ishikawa, Toru, additional, Tajiri, Kazuto, additional, Ochi, Hironori, additional, Yasuda, Satoshi, additional, Toyoda, Hidenori, additional, Ogawa, Chikara, additional, Nishimura, Takashi, additional, Hatanaka, Takeshi, additional, Kakizaki, Satoru, additional, Shimada, Noritomo, additional, Kawata, Kazuhito, additional, Tada, Fujimasa, additional, Ohama, Hideko, additional, Nouso, Kazuhiro, additional, Morishita, Asahiro, additional, Tsutsui, Akemi, additional, Nagano, Takuya, additional, Itokawa, Norio, additional, Okubo, Tomomi, additional, Arai, Taeang, additional, Imai, Michitaka, additional, Kosaka, Hisashi, additional, Naganuma, Atsushi, additional, Koizumi, Yohei, additional, Nakamura, Shinichiro, additional, Kaibori, Masaki, additional, Iijima, Hiroko, additional, Hiasa, Yoichi, additional, Cammarota, Antonella, additional, Burgio, Valentina, additional, Cascinu, Stefano, additional, and Casadei-Gardini, Andrea, additional
Published: 2022
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63. Risk factors for portopulmonary hypertension in patients with cirrhosis: a prospective, multicenter study

Author: Atsukawa, Masanori, primary, Tsubota, Akihito, additional, Kondo, Chisa, additional, Koyano, Kaori-Shioda, additional, Ishikawa, Toru, additional, Toyoda, Hidenori, additional, Takaguchi, Koichi, additional, Watanabe, Tsunamasa, additional, Matsuura, Kentaro, additional, Ogawa, Chikara, additional, Hiraoka, Atsushi, additional, Okubo, Hironao, additional, Tateyama, Masakuni, additional, Uojima, Haruki, additional, Nozaki, Akito, additional, Chuma, Makoto, additional, Kato, Keizo, additional, Mikami, Shigeru, additional, Tani, Joji, additional, Morishita, Asahiro, additional, Kawata, Kazuhito, additional, Tada, Toshifumi, additional, Furuichi, Yoshihiro, additional, Okubo, Tomomi, additional, Kawano, Tadamichi, additional, Arai, Taeang, additional, Kawabe, Naoto, additional, Kawamura, Naohiro, additional, Ikegami, Tadashi, additional, Nakamuta, Makoto, additional, Shigefuku, Ryuta, additional, Iwasa, Motoh, additional, Tanaka, Yasuhito, additional, Hatano, Masaru, additional, and Iwakiri, Katsuhiko, additional
Published: 2022
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64. Nutritional status is associated with prognosis in patients with advanced unresectable hepatocellular carcinoma treated with atezolizumab plus bevacizumab

Author: Tada, Toshifumi, primary, Kumada, Takashi, additional, Hiraoka, Atsushi, additional, Kariyama, Kazuya, additional, Tani, Joji, additional, Hirooka, Masashi, additional, Takaguchi, Koichi, additional, Atsukawa, Masanori, additional, Fukunishi, Shinya, additional, Itobayashi, Ei, additional, Tsuji, Kunihiko, additional, Tajiri, Kazuto, additional, Ochi, Hironori, additional, Ishikawa, Toru, additional, Yasuda, Satoshi, additional, Ogawa, Chikara, additional, Toyoda, Hidenori, additional, Hatanaka, Takeshi, additional, Nishimura, Takashi, additional, Kakizaki, Satoru, additional, Kawata, Kazuhito, additional, Shimada, Noritomo, additional, Tada, Fujimasa, additional, Nouso, Kazuhiro, additional, Tsutsui, Akemi, additional, Ohama, Hideko, additional, Morishita, Asahiro, additional, Nagano, Takuya, additional, Itokawa, Norio, additional, Okubo, Tomomi, additional, Arai, Taeang, additional, Kosaka, Hisashi, additional, Imai, Michitaka, additional, Naganuma, Atsushi, additional, Nakamura, Shinichiro, additional, Koizumi, Yohei, additional, Matono, Tomomitsu, additional, Kaibori, Masaki, additional, Iijima, Hiroko, additional, and Hiasa, Yoichi, additional
Published: 2022
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65. Association of serum albumin levels and long-term prognosis in patients with biopsy- confirmed nonalcoholic fatty liver disease

Author: Takahashi, Hirokazu, primary, Kawanaka, Miwa, additional, Fujii, Hideki, additional, Iwaki, Michihiro, additional, Hayashi, Hideki, additional, Toyoda, Hidenori, additional, Oeda, Satoshi, additional, Hyogo, Hideyuki, additional, Morishita, Asahiro, additional, Munekage, Kensuke, additional, Kawata, Kazuhito, additional, Tsutsumi, Tsubasa, additional, Sawada, Koji, additional, Maeshiro, Tatsuji, additional, Tobita, Hiroshi, additional, Yoshida, Yuichi, additional, Naito, Masafumi, additional, Araki, Asuka, additional, Arakaki, Shingo, additional, Kawaguch, Takumi, additional, Noritake, Hidenao, additional, Ono, Masafumi, additional, Masaki, Tsutomu, additional, Yasuda, Satoshi, additional, Tomita, Eiichi, additional, Yoneda, Masato, additional, Tokushige, Akihiro, additional, Kamada, Yoshihiro, additional, Ueda, Shinichiro, additional, Aishima, Shinichi, additional, Sumida, Yoshio, additional, Nakajima, Atsushi, additional, and Okanoue, Takeshi, additional
Published: 2022
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66. Arg-Gly-Asp-binding integrins activate hepatic stellate cells via the hippo signaling pathway

Author: Kitsugi, Kensuke, primary, Noritake, Hidenao, additional, Matsumoto, Moe, additional, Hanaoka, Tomohiko, additional, Umemura, Masahiro, additional, Yamashita, Maho, additional, Takatori, Shingo, additional, Ito, Jun, additional, Ohta, Kazuyoshi, additional, Chida, Takeshi, additional, Ulmasov, Barbara, additional, Neuschwander-Tetri, Brent A., additional, Suda, Takafumi, additional, and Kawata, Kazuhito, additional
Published: 2022
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67. DILATED MAIN PANCREATIC DUCT CAN BE A NEGATIVE PREDICTOR OF PANCREATITIS RELATED TO BILIARY SEMS INSERTION ACROSS THE PAPILLA

Author: Umemura, Masahiro, Shimura, Eri, Asai, Yusuke, Tsuji, Atsushi, Nishino, Masafumi, Takahashi, Yurimi, Sasada, Yuzo, Saida, Yasuhiko, Kawata, Kazuhito, Sugimoto, Ken, and Yamada, Takanori
Subjects: self-expandable metallic stent (SEMS), education, cardiovascular system, Post-ERCP pancreatitis (PEP), circulatory and respiratory physiology
Abstract: Objectives: Post-ERCP pancreatitis (PEP) after self-expandable metallic stent (SEMS) insertion across the papilla of Vater is an important adverse event that affects the patient’s quality of life (QOL). We examined the predictive factors of PEP after SEMS insertion to treat obstructive jaundice due to malignancy.Methods: Ninety patients who underwent biliary SEMS insertion for biliary obstruction due to malignancy at Iwata City Hospital between 2010 and 2018 were reviewed. We evaluated the relationship between the incidence of PEP after biliary SEMS insertion and clinical factors. We measured the thickness of the pancreatic parenchyma and diameter of the main pancreatic duct (MPD) at the left side of the corpus vertebrae.Results: Mild and severe PEP were diagnosed in 10 (11.1%) and 1 (1.1%) patients, respectively. Only the thickness of the pancreatic parenchyma and diameter of MPD significantly differed between the PEP and non-PEP groups. The incidence of PEP among patients whose thickness of the pancreatic parenchyma at the left side of the corpus vertebrae was less than 9.5 mm (0%) on computed tomography was lower than that in patients whose thickness was 9.5 mm or greater (34.4%). Similarly, a wider (5 mm or more) diameter of MPD (4.3%) reduced the incidence of PEP compared with a narrower diameter (40.0%). Logistic regression analysis revealed that the probability of PEP decreases 3.91-times for every 1-mm increase in MPD diameter (95% CI 1.23-12.4, p=0.02).Conclusion: Based on our study, a dilated MPD is a negative predictive factor of pancreatitis related to biliary SEMS insertion.
Published: 2021

68. Validation of the utility of Agile scores to identify advanced fibrosis and cirrhosis in Japanese patients with nonalcoholic fatty liver disease.

Author: Oeda, Satoshi, Seko, Yuya, Hayashi, Hideki, Arai, Taeang, Iwaki, Michihiro, Yoneda, Masato, Shima, Toshihide, Notsumata, Kazuo, Ikegami, Tadashi, Fujii, Hideki, Toyoda, Hidenori, Miura, Kouichi, Morishita, Asahiro, Kawata, Kazuhito, Tomita, Kengo, Kawanaka, Miwa, Isoda, Hiroshi, Yamaguchi, Kanji, Fukushima, Hideaki, and Kamada, Yoshihiro
Subjects: NON-alcoholic fatty liver disease, JAPANESE people, HEPATIC fibrosis, FIBROSIS, RECEIVER operating characteristic curves
Abstract: Aim: Agile 3+ and Agile 4 scores, based on liver stiffness measurement (LSM) by transient elastography and clinical parameters, were recently reported to be effective in identifying advanced fibrosis and cirrhosis in nonalcoholic fatty liver disease (NAFLD). This study aimed to validate the utility of these scores in Japanese patients with NAFLD. Methods: Six hundred forty‐one patients with biopsy‐proven NAFLD were analyzed. The severity of liver fibrosis was pathologically evaluated by one expert pathologist. The LSM, age, sex, diabetes status, platelet count, and aspartate aminotransferase and alanine aminotransferase levels were used to calculate Agile 3+ scores, and the parameters above excluding age were used for Agile 4 scores. The diagnostic performance of the two scores was evaluated using receiver operating characteristic (ROC) curve analysis. Sensitivity, specificity, and predictive values of the original low cut‐off (for rule‐out) value and high cut‐off (for rule‐in) value were tested. Results: For diagnosis of fibrosis stage ≥3, the area under the ROC (AUROC) was 0.886, and the sensitivity of the low cut‐off value and the specificity of the high cut‐off value were 95.3% and 73.4%, respectively. For diagnosis of fibrosis stage 4, AUROC, the sensitivity of the low cut‐off value, and the specificity of the high cut‐off value were 0.930, 100%, and 86.5%, respectively. Both scores had higher diagnostic performance than the FIB‐4 index and the enhanced liver fibrosis score. Conclusions: Agile 3+ and Agile 4 are reliable noninvasive tests to identify advanced fibrosis and cirrhosis in Japanese NAFLD patients with adequate diagnostic performance. [ABSTRACT FROM AUTHOR]
Published: 2023
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69. Noninvasive tests predict liver‐related events and mortality in patients with nonalcoholic fatty liver disease: sub‐analysis of the CLIONE‐Asia study.

Author: Ishiba, Hiroshi, Sumida, Yoshio, Kamada, Yoshihiro, Fujii, Hideki, Iwaki, Michihiro, Hayashi, Hideki, Toyoda, Hidenori, Oeda, Satoshi, Hyogo, Hideyuki, Kawanaka, Miwa, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Tsutsumi, Tsubasa, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, and Araki, Asuka
Subjects: NON-alcoholic fatty liver disease, FATTY liver, LIVER biopsy, JAPANESE people, REFERENCE values
Abstract: Background and Aims: Noninvasive tests (NITs) have prognostic potential, but whether NITs are comparable with liver biopsy is unclear. This study aimed to examine the prognostic accuracy of NITs for liver‐related mortality (LRM) and events (LREs) in patients with biopsy‐proven nonalcoholic fatty liver disease (NAFLD). Methods: We investigated 1313 patients with NAFLD. Patients were assigned to low‐risk, indeterminate‐risk, and high‐risk groups using conventional cutoff values of each FIB‐4 and NAFLD fibrosis score (NFS) and to stage 0–2 and stage 3–4 groups using the fibrosis stage. Survival and Cox regression analyses of the prognostic potential of NITs for LRM/LREs were conducted. Results: During a median follow‐up of 4.5 years, regarding to FIB‐4, the incidence rate (/1000 person‐years) in the low risk was zero for LRM and 0.5 for LREs. In contrast, the rate in stage 0–2 was 1.3 for LRM and 2.8 for LRE. The adjusted hazard ratios (aHRs) for LREs in the high risk compared with the low risk were 32.85 (P < 0.01). The aHRs in stage 3–4 compared with stage 0–2 were 2.68 (P = 0.02) for LREs and 2.26 (P = 0.582) for LRM. In the same fibrosis stage, the incidence of LRM/LREs was more frequent with a higher risk stratification. The same trend was observed for NFS. Conclusions: NITs accurately predict LRM and LREs as well as a liver biopsy in Japanese patients with NAFLD. Patients in the low risk may not require close follow‐up for at least 5 years. The simple NITs could be an acceptable alternative method to performing a liver biopsy for the prognosis of NAFLD. [ABSTRACT FROM AUTHOR]
Published: 2023
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70. Development and validation of a modified albumin-bilirubin grade and α-fetoprotein score (mALF score) for hepatocellular carcinoma patients receiving atezolizumab and bevacizumab.

Author: Hatanaka, Takeshi, primary, Kakizaki, Satoru, additional, Hiraoka, Atsushi, additional, Tada, Toshifumi, additional, Hirooka, Masashi, additional, Kariyama, Kazuya, additional, Tani, Joji, additional, Atsukawa, Masanori, additional, Takaguchi, Koichi, additional, Itobayashi, Ei, additional, Fukunishi, Shinya, additional, Tsuji, Kunihiko, additional, Ishikawa, Toru, additional, Tajiri, Kazuto, additional, Ochi, Hironori, additional, Yasuda, Satoshi, additional, Toyoda, Hidenori, additional, Ogawa, Chikara, additional, Nishimura, Takashi, additional, Shimada, Noritomo, additional, Kawata, Kazuhito, additional, Kosaka, Hisashi, additional, Tanaka, Takaaki, additional, Ohama, Hideko, additional, Nouso, Kazuhiro, additional, Morishita, Asahiro, additional, Tsutsui, Akemi, additional, Nagano, Takuya, additional, Itokawa, Norio, additional, Okubo, Tomomi, additional, Arai, Taeang, additional, Imai, Michitaka, additional, Naganuma, Atsushi, additional, Koizumi, Yohei, additional, Nakamura, Shinichiro, additional, Kaibori, Masaki, additional, Iijima, Hiroko, additional, Hiasa, Yoichi, additional, and Kumada, Takashi, additional
Published: 2022
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71. SAT-101 Morphological changes in esophageal varices in patients with HCVrelated cirrhosis who achieved sustained virological response by direct-acting antivirals

Author: Nagao, Chikako, Atsukawa, Masanori, Kawano, Tadamichi, Arai, Taeang, Tsubota, Akihito, Kondo, Chisa, Okubo, Tomomi, Toyoda, Hidenori, Takaguchi, Koichi, Nakamura, Makoto, Watanabe, Tsunamasa, Morishita, Asahiro, Okubo, Hironao, Hiraoka, Atsushi, Nozaki, Akito, Kawata, Kazuhito, Uojima, Haruki, Ogawa, Chikara, Ishikawa, Toru, Nishikawa, Hiroki, Iwasa, Motoh, Tanaka, Yasuhito, and Iwakiri, Katsuhiko
Published: 2024
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72. DILATED MAIN PANCREATIC DUCT CAN BE A NEGATIVE PREDICTOR OF PANCREATITIS RELATED TO BILIARY SEMS INSERTION ACROSS THE PAPILLA

Author: Umemura, Masahiro, Shimura, Eri, Asai, Yusuke, Tsuji, Atsushi, Nishino, Masafumi, Takahashi, Yurimi, Sasada, Yuzo, Saida, Yasuhiko, Kawata, Kazuhito, Sugimoto, Ken, Yamada, Takanori, Umemura, Masahiro, Shimura, Eri, Asai, Yusuke, Tsuji, Atsushi, Nishino, Masafumi, Takahashi, Yurimi, Sasada, Yuzo, Saida, Yasuhiko, Kawata, Kazuhito, Sugimoto, Ken, and Yamada, Takanori
Abstract: Objectives: Post-ERCP pancreatitis (PEP) after self-expandable metallic stent (SEMS) insertion across the papilla of Vater is an important adverse event that affects the patient’s quality of life (QOL). We examined the predictive factors of PEP after SEMS insertion to treat obstructive jaundice due to malignancy.Methods: Ninety patients who underwent biliary SEMS insertion for biliary obstruction due to malignancy at Iwata City Hospital between 2010 and 2018 were reviewed. We evaluated the relationship between the incidence of PEP after biliary SEMS insertion and clinical factors. We measured the thickness of the pancreatic parenchyma and diameter of the main pancreatic duct (MPD) at the left side of the corpus vertebrae.Results: Mild and severe PEP were diagnosed in 10 (11.1%) and 1 (1.1%) patients, respectively. Only the thickness of the pancreatic parenchyma and diameter of MPD significantly differed between the PEP and non-PEP groups. The incidence of PEP among patients whose thickness of the pancreatic parenchyma at the left side of the corpus vertebrae was less than 9.5 mm (0%) on computed tomography was lower than that in patients whose thickness was 9.5 mm or greater (34.4%). Similarly, a wider (5 mm or more) diameter of MPD (4.3%) reduced the incidence of PEP compared with a narrower diameter (40.0%). Logistic regression analysis revealed that the probability of PEP decreases 3.91-times for every 1-mm increase in MPD diameter (95% CI 1.23-12.4, p=0.02).Conclusion: Based on our study, a dilated MPD is a negative predictive factor of pancreatitis related to biliary SEMS insertion.
Published: 2022

73. Critical role of CREBH‐mediated induction of transforming growth factor β2 by hepatitis C virus infection in fibrogenic responses in hepatic stellate cells

Author: Chida, Takeshi, Ito, Masahiko, Nakashima, Kenji, Kanegae, Yumi, Aoshima, Takuya, Takabayashi, Shuji, Kawata, Kazuhito, Nakagawa, Yoshimi, Yamamoto, Masahiro, Shimano, Hitoshi, Matsuura, Tomokazu, Kobayashi, Yoshimasa, Suda, Takafumi, and Suzuki, Tetsuro
Published: 2017
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74. Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease.

Author: Takahashi, Hirokazu, Kawanaka, Miwa, Fujii, Hideki, Iwaki, Michihiro, Hayashi, Hideki, Toyoda, Hidenori, Oeda, Satoshi, Hyogo, Hideyuki, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Tsutsumi, Tsubasa, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, Araki, Asuka, Arakaki, Shingo, and Kawaguchi, Takumi
Abstract: The relationship between baseline serum albumin level and long-term prognosis of patients with nonalcoholic fatty liver disease (NAFLD) remains unknown. This is a sub-analysis of the CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) study. The main outcomes were: death or orthotopic liver transplantation (OLT), liver-related death, and liver-related events (hepatocellular carcinoma [HCC], decompensated cirrhosis, and gastroesophageal varices/bleeding). 1383 Japanese patients with biopsy-confirmed NAFLD were analyzed. They were divided into 3 groups based on serum albumin: high (>4.0 g/dL), intermediate (3.5–4.0 g/dL), and low (<3.5 g/dL). Unadjusted hazard ratio [HR] of the intermediate albumin group, compared with the high albumin group, were 3.6 for death or OLT, 11.2 for liver-related death, 4.6 for HCC, 8.2 for decompensated cirrhosis, and 6.2 for gastroesophageal varices (all risks were statistically significant). After adjusting confounding factors, albumin remained significantly associated with death or OLT (intermediate vs. high albumin group: HR 3.06, 95% confidence interval [CI] 1.59–5.91, p < 0.001; low vs. high albumin group: HR 22.9, 95% CI 8.21–63.9, p < 0.001). Among biopsy-confirmed NAFLD patients, those with intermediate or low serum albumin had a significantly higher risk of death or OLT than those with high serum albumin. [ABSTRACT FROM AUTHOR]
Published: 2023
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75. Multicenter, retrospective, cohort study shows platelet counts predict hepatocellular carcinoma development in patients with nonalcoholic fatty liver disease.

Author: Fujii, Hideki, Fujii, Makoto, Iwaki, Michihiro, Hayashi, Hideki, Toyoda, Hidenori, Oeda, Satoshi, Hyogo, Hideyuki, Kawanaka, Miwa, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Tsutsumi, Tsubasa, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, Araki, Asuka, Arakaki, Shingo, and Kawaguchi, Takumi
Subjects: NON-alcoholic fatty liver disease, FATTY liver, PLATELET count, HEPATOCELLULAR carcinoma, PROGNOSIS, COHORT analysis
Abstract: Aim: Impacts of platelet counts at the time of liver biopsy on hepatocellular carcinoma (HCC) development in patients with nonalcoholic fatty liver disease (NAFLD) remain unknown. The aim of this study was to investigate the prognostic value of platelet counts in patients with biopsy‐confirmed NAFLD using data from a multicenter study. Methods: One thousand three hundred ninety‐eight patients were included in this subanalysis of the CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) in Asia study. Liver biopsy specimens were pathologically diagnosed, and histologically scored using the NASH Clinical Research Network system. Demographic, clinical, laboratory, and pathological data were collected. Results: During a median follow‐up period of 4.6 years (range, 0.3–21.6 years), which corresponds to 8874 person‐years, 37 patients developed HCC. Using a cut‐off baseline platelet count of 192 × 109/L, the lower platelet group had a higher HCC rate than the higher platelet group (6.7% vs. 0.4%; p < 0.001). This cut‐off value significantly stratified the event‐free rate for HCC. Lower platelet counts were associated with an increased risk of HCC development. Relative to patients with platelet counts of 192 × 109/L, patients with platelet counts of 100 × 109/L had an unadjusted hazard ratio (HR) for HCC development of 7.37 (95% confidence interval [CI], 3.81–14.2) and an adjusted HR of 11.2 (95% CI, 3.81–32.7; p < 0.001), adjusting for age, sex, NASH, and diabetes. Conclusions: Baseline platelet counts of 192 × 109/L and lower are associated with a higher risk of developing HCC in patients with biopsy‐confirmed NAFLD and require active surveillance. [ABSTRACT FROM AUTHOR]
Published: 2023
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76. Diagnostic accuracy of enhanced liver fibrosis test for nonalcoholic steatohepatitis‐related fibrosis: Multicenter study.

Author: Seko, Yuya, Takahashi, Hirokazu, Toyoda, Hidenori, Hayashi, Hideki, Yamaguchi, Kanji, Iwaki, Michihiro, Yoneda, Masato, Arai, Taeang, Shima, Toshihide, Fujii, Hideki, Morishita, Asahiro, Kawata, Kazuhito, Tomita, Kengo, Kawanaka, Miwa, Yoshida, Yuichi, Ikegami, Tadashi, Notsumata, Kazuo, Oeda, Satoshi, Kamada, Yoshihiro, and Sumida, Yoshio
Subjects: FATTY liver, HEPATIC fibrosis, NON-alcoholic fatty liver disease, FIBROSIS, MEDIAN (Mathematics), JAPANESE people
Abstract: Aim: The enhanced liver fibrosis (ELF) test is a noninvasive method for diagnosing hepatic fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). This multicenter cohort study aimed to evaluate the accuracy of the ELF test and compare it with other noninvasive tests in Japan. Methods: We analyzed 371 Japanese patients with biopsy‐proven NAFLD. We constructed area under the receiver operator characteristic curves (AUROC) to determine the diagnostic accuracies of the ELF test, the Mac‐2‐binding protein glycosylation isomer (M2BPGi), the Fibrosis‐4 (FIB‐4) index, and combinations of these indices. Results: In patients with F0/F1/F2/F3/F4 fibrosis, the median values of the ELF test were 8.98/9.56/10.39/10.92/11.41, respectively. The AUROCs of the ELF test for patients with F0 versus F1–4, F0–1 versus F2–4, F0–2 versus F3–4, and F0–3 versus F4 fibrosis were 0.825/0.817/0.802/0.812, respectively. The AUROCs of the ELF test were greater than those of the FIB‐4 index and M2BPGi at each fibrosis stage. Respective low and high cut‐off values yielded sensitivities and specificities for predicting advanced fibrosis (≥F3) of 91.1% and 50.8%, and 38.5% and 92.8%, respectively. For F3 or F4 fibrosis, the combined values from the ELF test and FIB‐4 index showed a sensitivity of 98.5%, and the combined values from the ELF test and M2BPGi assay showed a specificity of 97.5%. Conclusions: In Japan, the ELF test predicts NAFLD‐related fibrosis from its early stages. The diagnostic ability of the ELF test was not inferior to that of other indices, and the combined values of ELF plus other indices were more accurate. [ABSTRACT FROM AUTHOR]
Published: 2023
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77. Mac‐2‐binding protein glycan isomer predicts all malignancies after sustained virological response in chronic hepatitis C

Author: Kawata, Kazuhito, primary, Atsukawa, Masanori, additional, Ohta, Kazuyoshi, additional, Chida, Takeshi, additional, Noritake, Hidenao, additional, Arai, Taeang, additional, Iwakiri, Katsuhiko, additional, Yasuda, Satoshi, additional, Toyoda, Hidenori, additional, Okubo, Tomomi, additional, Hiraoka, Atsushi, additional, Watanabe, Tsunamasa, additional, Uojima, Haruki, additional, Nozaki, Akito, additional, Tani, Joji, additional, Morishita, Asahiro, additional, Kageyama, Fujito, additional, Sasada, Yuzo, additional, Nagasawa, Masamichi, additional, Matsushita, Masahiro, additional, Oyaizu, Tatsuki, additional, Mikami, Shigeru, additional, Ikegami, Tadashi, additional, Abe, Hiroshi, additional, Matsuura, Kentaro, additional, Tanaka, Yasuhito, additional, and Tsubota, Akihito, additional
Published: 2022
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78. Prognostic impact of C-reactive protein and alpha-fetoprotein in immunotherapy score in hepatocellular carcinoma patients treated with atezolizumab plus bevacizumab: A multicenter retrospective study

Author: Hatanaka, Takeshi, primary, Kakizaki, Satoru, additional, Hiraoka, Atsushi, additional, Tada, Toshifumi, additional, Hirooka, Masashi, additional, Kariyama, Kazuya, additional, Tani, Joji, additional, Atsukawa, Masanori, additional, Takaguchi, Koichi, additional, Itobayashi, Ei, additional, Fukunishi, Shinya, additional, Tsuji, Kunihiko, additional, Ishikawa, Toru, additional, Tajiri, Kazuto, additional, Ochi, Hironori, additional, Yasuda, Satoshi, additional, Toyoda, Hidenori, additional, Ogawa, Chikara, additional, Nishimura, Takashi, additional, Shimada, Noritomo, additional, Kawata, Kazuhito, additional, Kosaka, Hisashi, additional, Tanaka, Takaaki, additional, Ohama, Hideko, additional, Nouso, Kazuhiro, additional, Morishita, Asahiro, additional, Tsutsui, Akemi, additional, Nagano, Takuya, additional, Itokawa, Norio, additional, Okubo, Tomomi, additional, Arai, Taeang, additional, Imai, Michitaka, additional, Naganuma, Atsushi, additional, Koizumi, Yohei, additional, Nakamura, Shinichiro, additional, Joko, Kouji, additional, Kaibori, Masaki, additional, Iijima, Hiroko, additional, Hiasa, Yoichi, additional, and Kumada, Takashi, additional
Published: 2022
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79. Corrigendum to ‘An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs’ [J Hepatol 2021;75(3):572–581]

Author: Cordell, Heather J., primary, Fryett, James J., additional, Ueno, Kazuko, additional, Darlay, Rebecca, additional, Aiba, Yoshihiro, additional, Hitomi, Yuki, additional, Kawashima, Minae, additional, Nishida, Nao, additional, Khor, Seik-Soon, additional, Gervais, Olivier, additional, Kawai, Yosuke, additional, Nagasaki, Masao, additional, Tokunaga, Katsushi, additional, Tang, Ruqi, additional, Shi, Yongyong, additional, Li, Zhiqiang, additional, Juran, Brian D., additional, Atkinson, Elizabeth J., additional, Gerussi, Alessio, additional, Carbone, Marco, additional, Asselta, Rosanna, additional, Cheung, Angela, additional, de Andrade, Mariza, additional, Baras, Aris, additional, Horowitz, Julie, additional, Ferreira, Manuel A.R., additional, Sun, Dylan, additional, Jones, David E., additional, Flack, Steven, additional, Spicer, Ann, additional, Mulcahy, Victoria L., additional, Byun, Jinyoung, additional, Han, Younghun, additional, Sandford, Richard N., additional, Lazaridis, Konstantinos N., additional, Amos, Christopher I., additional, Hirschfield, Gideon M., additional, Seldin, Michael F., additional, Invernizzi, Pietro, additional, Siminovitch, Katherine A., additional, Ma, Xiong, additional, Nakamura, Minoru, additional, Mells, George F., additional, Mason, Andrew, additional, Vincent, Catherine, additional, Xie, Gang, additional, Zhang, Jinyi, additional, Affronti, Andrea, additional, Almasio, Piero L., additional, Alvaro, Domenico, additional, Andreone, Pietro, additional, Andriulli, Angelo, additional, Azzaroli, Francesco, additional, Battezzati, Pier Maria, additional, Benedetti, Antonio, additional, Bragazzi, MariaConsiglia, additional, Brunetto, Maurizia, additional, Bruno, Savino, additional, Calvaruso, Vincenza, additional, Cardinale, Vincenzo, additional, Casella, Giovanni, additional, Cazzagon, Nora, additional, Ciaccio, Antonio, additional, Coco, Barbara, additional, Colli, Agostino, additional, Colloredo, Guido, additional, Colombo, Massimo, additional, Colombo, Silvia, additional, Cristoferi, Laura, additional, Cursaro, Carmela, additional, Crocè, Lory Saveria, additional, Crosignani, Andrea, additional, D’Amato, Daphne, additional, Donato, Francesca, additional, Elia, Gianfranco, additional, Fabris, Luca, additional, Fagiuoli, Stefano, additional, Ferrari, Carlo, additional, Floreani, Annarosa, additional, Galli, Andrea, additional, Giannini, Edoardo, additional, Grattagliano, Ignazio, additional, Lampertico, Pietro, additional, Lleo, Ana, additional, Malinverno, Federica, additional, Mancuso, Clara, additional, Marra, Fabio, additional, Marzioni, Marco, additional, Massironi, Sara, additional, Mattalia, Alberto, additional, Miele, Luca, additional, Milani, Chiara, additional, Morini, Lorenzo, additional, Morisco, Filomena, additional, Muratori, Luigi, additional, Muratori, Paolo, additional, Niro, Grazia A., additional, O’Donnell, Sarah, additional, Picciotto, Antonio, additional, Portincasa, Piero, additional, Rigamonti, Cristina, additional, Ronca, Vincenzo, additional, Rosina, Floriano, additional, Spinzi, Giancarlo, additional, Strazzabosco, Mario, additional, Tarocchi, Mirko, additional, Tiribelli, Claudio, additional, Toniutto, Pierluigi, additional, Valenti, Luca, additional, Vinci, Maria, additional, Zuin, Massimo, additional, Nakamura, Hitomi, additional, Abiru, Seigo, additional, Nagaoka, Shinya, additional, Komori, Atsumasa, additional, Yatsuhashi, Hiroshi, additional, Ishibashi, Hiromi, additional, Ito, Masahiro, additional, Migita, Kiyoshi, additional, Ohira, Hiromasa, additional, Katsushima, Shinji, additional, Naganuma, Atsushi, additional, Sugi, Kazuhiro, additional, Komatsu, Tatsuji, additional, Mannami, Tomohiko, additional, Matsushita, Kouki, additional, Yoshizawa, Kaname, additional, Makita, Fujio, additional, Nikami, Toshiki, additional, Nishimura, Hideo, additional, Kouno, Hiroshi, additional, Kouno, Hirotaka, additional, Ota, Hajime, additional, Komura, Takuya, additional, Nakamura, Yoko, additional, Shimada, Masaaki, additional, Hirashima, Noboru, additional, Komeda, Toshiki, additional, Ario, Keisuke, additional, Nakamuta, Makoto, additional, Yamashita, Tsutomu, additional, Furuta, Kiyoshi, additional, Kikuchi, Masahiro, additional, Naeshiro, Noriaki, additional, Takahashi, Hironao, additional, Mano, Yutaka, additional, Tsunematsu, Seiji, additional, Yabuuchi, Iwao, additional, Shimada, Yusuke, additional, Yamauchi, Kazuhiko, additional, Sugimoto, Rie, additional, Sakai, Hironori, additional, Mita, Eiji, additional, Koda, Masaharu, additional, Tsuruta, Satoru, additional, Kamitsukasa, Hiroshi, additional, Sato, Takeaki, additional, Masaki, Naohiko, additional, Kobata, Tatsuro, additional, Fukushima, Nobuyoshi, additional, Ohara, Yukio, additional, Muro, Toyokichi, additional, Takesaki, Eiichi, additional, Takaki, Hitoshi, additional, Yamamoto, Tetsuo, additional, Kato, Michio, additional, Nagaoki, Yuko, additional, Hayashi, Shigeki, additional, Ishida, Jinya, additional, Watanabe, Yukio, additional, Kobayashi, Masakazu, additional, Koga, Michiaki, additional, Saoshiro, Takeo, additional, Yagura, Michiyasu, additional, Hirata, Keisuke, additional, Tanaka, Atsushu, additional, Takikawa, Hajime, additional, Zeniya, Mikio, additional, Abe, Masanori, additional, Onji, Morikazu, additional, Kaneko, Shuichi, additional, Honda, Masao, additional, Arai, Kuniaki, additional, Arinaga-Hino, Teruko, additional, Hashimoto, Etsuko, additional, Taniai, Makiko, additional, Umemura, Takeji, additional, Joshita, Satoru, additional, Nakao, Kazuhiko, additional, Ichikawa, Tatsuki, additional, Shibata, Hidetaka, additional, Yamagiwa, Satoshi, additional, Seike, Masataka, additional, Honda, Koichi, additional, Sakisaka, Shotaro, additional, Takeyama, Yasuaki, additional, Harada, Masaru, additional, Senju, Michio, additional, Yokosuka, Osamu, additional, Kanda, Tatsuo, additional, Ueno, Yoshiyuki, additional, Kikuchi, Kentaro, additional, Ebinuma, Hirotoshi, additional, Himoto, Takashi, additional, Yasunami, Michio, additional, Murata, Kazumoto, additional, Mizokami, Masashi, additional, Kawata, Kazuhito, additional, Shimoda, Shinji, additional, Miyake, Yasuhiro, additional, Takaki, Akinobu, additional, Yamamoto, Kazuhide, additional, Hirano, Katsuji, additional, Ichida, Takafumi, additional, Ido, Akio, additional, Tsubouchi, Hirohito, additional, Chayama, Kazuaki, additional, Harada, Kenichi, additional, Nakanuma, Yasuni, additional, Maehara, Yoshihiko, additional, Taketomi, Akinobu, additional, Shirabe, Ken, additional, Soejima, Yuji, additional, Mori, Akira, additional, Yagi, Shintaro, additional, Uemoto, Shinji, additional, H, Egawa, additional, Tanaka, Tomohiro, additional, Yamashiki, Noriyo, additional, Tamura, Sumito, additional, Sugawara, Yasuhiro, additional, Kokudo, Norihiro, additional, Chalasani, Naga, additional, Luketic, Vel, additional, Odin, Joseph, additional, Chopra, Kapil, additional, Abecasis, Goncalo, additional, Cantor, Michael, additional, Coppola, Giovanni, additional, Economides, Aris, additional, Lotta, Luca A., additional, Overton, John D., additional, Reid, Jeffrey G., additional, Shuldiner, Alan, additional, Beechert, Christina, additional, Forsythe, Caitlin, additional, Fuller, Erin D., additional, Gu, Zhenhua, additional, Lattari, Michael, additional, Lopez, Alexander, additional, Schleicher, Thomas D., additional, Padilla, Maria Sotiropoulos, additional, Toledo, Karina, additional, Widom, Louis, additional, Wolf, Sarah E., additional, Pradhan, Manasi, additional, Manoochehri, Kia, additional, Ulloa, Ricardo H., additional, Bai, Xiaodong, additional, Balasubramanian, Suganthi, additional, Barnard, Leland, additional, Blumenfeld, Andrew, additional, Eom, Gisu, additional, Habegger, Lukas, additional, Hawes, Alicia, additional, Khalid, Shareef, additional, Maxwell, Evan K., additional, Salerno, William, additional, Staples, Jeffrey C., additional, Jones, Marcus B., additional, Mitnaul, Lyndon J., additional, Sturgess, Richard, additional, Healey, Christopher, additional, Yeoman, Andrew, additional, Gunasekera, Anton VJ., additional, Kooner, Paul, additional, Kapur, Kapil, additional, Sathyanarayana, V., additional, Kallis, Yiannis, additional, Subhani, Javaid, additional, Harvey, Rory, additional, McCorry, Roger, additional, Rooney, Paul, additional, Ramanaden, David, additional, Evans, Richard, additional, Mathialahan, Thiriloganathan, additional, Gasem, Jaber, additional, Shorrock, Christopher, additional, Bhalme, Mahesh, additional, Southern, Paul, additional, Tibble, Jeremy A., additional, Gorard, David A., additional, Jones, Susan, additional, Mells, George, additional, Mulcahy, Victoria, additional, Srivastava, Brijesh, additional, Foxton, Matthew R., additional, Collins, Carole E., additional, Elphick, David, additional, Karmo, Mazn, additional, Porras-Perez, Francisco, additional, Mendall, Michael, additional, Yapp, Tom, additional, Patel, Minesh, additional, Ede, Roland, additional, Sayer, Joanne, additional, Jupp, James, additional, Fisher, Neil, additional, Carter, Martyn J., additional, Koss, Konrad, additional, Shah, Jayshri, additional, Piotrowicz, Andrzej, additional, Scott, Glyn, additional, Grimley, Charles, additional, Gooding, Ian R., additional, Williams, Simon, additional, Tidbury, Judith, additional, Lim, Guan, additional, Cheent, Kuldeep, additional, Levi, Sass, additional, Mansour, Dina, additional, Beckley, Matilda, additional, Hollywood, Coral, additional, Wong, Terry, additional, Marley, Richard, additional, Ramage, John, additional, Gordon, Harriet M., additional, Ridpath, Jo, additional, Ngatchu, Theodore, additional, Bob Grover, Vijay Paul, additional, Shidrawi, Ray G., additional, Abouda, George, additional, Corless, L., additional, Narain, Mark, additional, Rees, Ian, additional, Brown, Ashley, additional, Taylor-Robinson, Simon, additional, Wilkins, Joy, additional, Grellier, Leonie, additional, Banim, Paul, additional, Das, Debasish, additional, Heneghan, Michael A., additional, Curtis, Howard, additional, Matthews, Helen C., additional, Mohammed, Faiyaz, additional, Aldersley, Mark, additional, Srirajaskanthan, Raj, additional, Walker, Giles, additional, McNair, Alistair, additional, Sharif, Amar, additional, Sen, Sambit, additional, Bird, George, additional, Prince, Martin I., additional, Prasad, Geeta, additional, Kitchen, Paul, additional, Barnardo, Adrian, additional, Oza, Chirag, additional, Sivaramakrishnan, Nurani N., additional, Gupta, Prakash, additional, Shah, Amir, additional, Evans, Chris DJ., additional, Saha, Subrata, additional, Pollock, Katharine, additional, Bramley, Peter, additional, Mukhopadhya, Ashis, additional, Barclay, Stephen T., additional, McDonald, Natasha, additional, Bathgate, Andrew J., additional, Palmer, Kelvin, additional, Dillon, John F., additional, Rushbrook, Simon M., additional, Przemioslo, Robert, additional, McDonald, Chris, additional, Millar, Andrew, additional, Tai, Cheh, additional, Mitchell, Stephen, additional, Metcalf, Jane, additional, Shaukat, Syed, additional, Ninkovic, Mary, additional, Shmueli, Udi, additional, Davis, Andrew, additional, Naqvi, Asifabbas, additional, Lee, Tom JW., additional, Ryder, Stephen, additional, Collier, Jane, additional, Klass, Howard, additional, Cramp, Matthew E., additional, Sharer, Nichols, additional, Aspinall, Richard, additional, Ghosh, Deb, additional, Douds, Andrew C., additional, Booth, Jonathan, additional, Williams, Earl, additional, Hussaini, Hyder, additional, Christie, John, additional, Mann, Steven, additional, Thorburn, Douglas, additional, Marshall, Aileen, additional, Patanwala, Imran, additional, Ala, Aftab, additional, Maltby, Julia, additional, Matthew, Ray, additional, Corbett, Chris, additional, Vyas, Sam, additional, Singhal, Saket, additional, Gleeson, Dermot, additional, Misra, Sharat, additional, Butterworth, Jeff, additional, George, Keith, additional, Harding, Tim, additional, Douglass, Andrew, additional, Mitchison, Harriet, additional, Panter, Simon, additional, Shearman, Jeremy, additional, Bray, Gary, additional, Roberts, Michael, additional, Butcher, Graham, additional, Forton, Daniel, additional, Mahmood, Zahid, additional, Cowan, Matthew, additional, Das, Debashis, additional, Ch'ng, Chin Lye, additional, Rahman, Mesbah, additional, Whatley, Gregory C.A., additional, Wesley, Emma, additional, Mandal, Aditya, additional, Jain, Sanjiv, additional, Pereira, Stephen P., additional, Wright, Mark, additional, Trivedi, Palak, additional, Gordon, Fiona H., additional, Unitt, Esther, additional, Palejwala, Altaf, additional, Austin, Andrew, additional, Vemala, Vishwaraj, additional, Grant, Allister, additional, Higham, Andrew D., additional, Brind, Alison, additional, Mathew, Ray, additional, Cox, Mark, additional, Ramakrishnan, Subramaniam, additional, King, Alistair, additional, Whalley, Simon, additional, Fraser, Jocelyn, additional, Thomson, S.J., additional, Bell, Andrew, additional, Wong, Voi Shim, additional, Kia, Richard, additional, Gee, Ian, additional, Keld, Richard, additional, Ransford, Rupert, additional, Gotto, James, additional, and Millson, Charles, additional
Published: 2021
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80. Environmental factors, medical and family history, and comorbidities associated with primary biliary cholangitis in Japan: a multicenter case–control study

Author: Matsumoto, Kosuke, primary, Ohfuji, Satoko, additional, Abe, Masanori, additional, Komori, Atsumasa, additional, Takahashi, Atsushi, additional, Fujii, Hideki, additional, Kawata, Kazuhito, additional, Noritake, Hidenao, additional, Tadokoro, Tomoko, additional, Honda, Akira, additional, Asami, Maiko, additional, Namisaki, Tadashi, additional, Ueno, Masayuki, additional, Sato, Ken, additional, Kakisaka, Keisuke, additional, Arakawa, Mie, additional, Ito, Takanori, additional, Tanaka, Kazunari, additional, Matsui, Takeshi, additional, Setsu, Toru, additional, Takamura, Masaaki, additional, Yasuda, Satoshi, additional, Katsumi, Tomohiro, additional, Itakura, Jun, additional, Sano, Tomoya, additional, Tamura, Yamato, additional, Miura, Ryo, additional, Arizumi, Toshihiko, additional, Asaoka, Yoshinari, additional, Uno, Kiyoko, additional, Nishitani, Ai, additional, Ueno, Yoshiyuki, additional, Terai, Shuji, additional, Takikawa, Yasuhiro, additional, Morimoto, Youichi, additional, Yoshiji, Hitoshi, additional, Mochida, Satoshi, additional, Ikegami, Tadashi, additional, Masaki, Tsutomu, additional, Kawada, Norifumi, additional, Ohira, Hiromasa, additional, and Tanaka, Atsushi, additional
Published: 2021
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81. C-Reactive Protein to Albumin Ratio Predicts Survival in Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib: A Multicenter Analysis

Author: Tada, Toshifumi, primary, Kumada, Takashi, additional, Hiraoka, Atsushi, additional, Hirooka, Masashi, additional, Kariyama, Kazuya, additional, Tani, Joji, additional, Atsukawa, Masanori, additional, Takaguchi, Koichi, additional, Itobayashi, Ei, additional, Fukunishi, Shinya, additional, Tsuji, Kunihiko, additional, Ishikawa, Toru, additional, Tajiri, Kazuto, additional, Ochi, Hironori, additional, Yasuda, Satoshi, additional, Toyoda, Hidenori, additional, Hatanaka, Takeshi, additional, Kakizaki, Satoru, additional, Shimada, Noritomo, additional, Kawata, Kazuhito, additional, Tanaka, Takaaki, additional, Ohama, Hideko, additional, Nouso, Kazuhiro, additional, Morishita, Asahiro, additional, Tsutsui, Akemi, additional, Nagano, Takuya, additional, Itokawa, Norio, additional, Okubo, Tomomi, additional, Arai, Taeang, additional, Imai, Michitaka, additional, Naganuma, Atsushi, additional, Aoki, Tomoko, additional, Koizumi, Yohei, additional, Nakamura, Shinichiro, additional, Joko, Kouji, additional, Hiasa, Yoichi, additional, and Kudo, Masatoshi, additional
Published: 2021
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82. Spontaneous clearance of serum hepatitis C virus RNA in an untreated patient with decompensated cirrhosis

Author: Matsumoto, Moe, primary, Matsushita, Masahiro, additional, Takeshita, Yu, additional, Yokota, Akihiko, additional, Hanaoka, Tomohiko, additional, Uozaki, Hiroki, additional, Watanabe, Shin-ya, additional, Kanayama, Hirokazu, additional, Ishibashi, Kohei, additional, and Kawata, Kazuhito, additional
Published: 2021
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83. An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

Author: Cordell, Heather J., primary, Fryett, James J., additional, Ueno, Kazuko, additional, Darlay, Rebecca, additional, Aiba, Yoshihiro, additional, Hitomi, Yuki, additional, Kawashima, Minae, additional, Nishida, Nao, additional, Khor, Seik-Soon, additional, Gervais, Olivier, additional, Kawai, Yosuke, additional, Nagasaki, Masao, additional, Tokunaga, Katsushi, additional, Tang, Ruqi, additional, Shi, Yongyong, additional, Li, Zhiqiang, additional, Juran, Brian D., additional, Atkinson, Elizabeth J., additional, Gerussi, Alessio, additional, Carbone, Marco, additional, Asselta, Rosanna, additional, Cheung, Angela, additional, de Andrade, Mariza, additional, Baras, Aris, additional, Horowitz, Julie, additional, Ferreira, Manuel A.R., additional, Sun, Dylan, additional, Jones, David E., additional, Flack, Steven, additional, Spicer, Ann, additional, Mulcahy, Victoria L., additional, Byan, Jinyoung, additional, Han, Younghun, additional, Sandford, Richard N., additional, Lazaridis, Konstantinos N., additional, Amos, Christopher I., additional, Hirschfield, Gideon M., additional, Seldin, Michael F., additional, Invernizzi, Pietro, additional, Siminovitch, Katherine A., additional, Ma, Xiong, additional, Nakamura, Minoru, additional, Mells, George F., additional, Mason, Andrew, additional, Vincent, Catherine, additional, Xie, Gang, additional, Zhang, Jinyi, additional, Affronti, Andrea, additional, Almasio, Piero L., additional, Alvaro, Domenico, additional, Andreone, Pietro, additional, Andriulli, Angelo, additional, Azzaroli, Francesco, additional, Battezzati, Pier Maria, additional, Benedetti, Antonio, additional, Bragazzi, MariaConsiglia, additional, Brunetto, Maurizia, additional, Bruno, Savino, additional, Calvaruso, Vincenza, additional, Cardinale, Vincenzo, additional, Casella, Giovanni, additional, Cazzagon, Nora, additional, Ciaccio, Antonio, additional, Coco, Barbara, additional, Colli, Agostino, additional, Colloredo, Guido, additional, Colombo, Massimo, additional, Colombo, Silvia, additional, Cristoferi, Laura, additional, Cursaro, Carmela, additional, Crocè, Lory Saveria, additional, Crosignani, Andrea, additional, D’Amato, Daphne, additional, Donato, Francesca, additional, Elia, Gianfranco, additional, Fabris, Luca, additional, Fagiuoli, Stefano, additional, Ferrari, Carlo, additional, Floreani, Annarosa, additional, Galli, Andrea, additional, Giannini, Edoardo, additional, Grattagliano, Ignazio, additional, Lampertico, Pietro, additional, Lleo, Ana, additional, Malinverno, Federica, additional, Mancuso, Clara, additional, Marra, Fabio, additional, Marzioni, Marco, additional, Massironi, Sara, additional, Mattalia, Alberto, additional, Miele, Luca, additional, Milani, Chiara, additional, Morini, Lorenzo, additional, Morisco, Filomena, additional, Muratori, Luigi, additional, Muratori, Paolo, additional, Niro, Grazia A., additional, O’Donnell, Sarah, additional, Picciotto, Antonio, additional, Portincasa, Piero, additional, Rigamonti, Cristina, additional, Ronca, Vincenzo, additional, Rosina, Floriano, additional, Spinzi, Giancarlo, additional, Strazzabosco, Mario, additional, Tarocchi, Mirko, additional, Tiribelli, Claudio, additional, Toniutto, Pierluigi, additional, Valenti, Luca, additional, Vinci, Maria, additional, Zuin, Massimo, additional, Nakamura, Hitomi, additional, Abiru, Seigo, additional, Nagaoka, Shinya, additional, Komori, Atsumasa, additional, Yatsuhashi, Hiroshi, additional, Ishibashi, Hiromi, additional, Ito, Masahiro, additional, Migita, Kiyoshi, additional, Ohira, Hiromasa, additional, Katsushima, Shinji, additional, Naganuma, Atsushi, additional, Sugi, Kazuhiro, additional, Komatsu, Tatsuji, additional, Mannami, Tomohiko, additional, Matsushita, Kouki, additional, Yoshizawa, Kaname, additional, Makita, Fujio, additional, Nikami, Toshiki, additional, Nishimura, Hideo, additional, Kouno, Hiroshi, additional, Kouno, Hirotaka, additional, Ota, Hajime, additional, Komura, Takuya, additional, Nakamura, Yoko, additional, Shimada, Masaaki, additional, Hirashima, Noboru, additional, Komeda, Toshiki, additional, Ario, Keisuke, additional, Nakamuta, Makoto, additional, Yamashita, Tsutomu, additional, Furuta, Kiyoshi, additional, Kikuchi, Masahiro, additional, Naeshiro, Noriaki, additional, Takahashi, Hironao, additional, Mano, Yutaka, additional, Tsunematsu, Seiji, additional, Yabuuchi, Iwao, additional, Shimada, Yusuke, additional, Yamauchi, Kazuhiko, additional, Sugimoto, Rie, additional, Sakai, Hironori, additional, Mita, Eiji, additional, Koda, Masaharu, additional, Tsuruta, Satoru, additional, Kamitsukasa, Hiroshi, additional, Sato, Takeaki, additional, Masaki, Naohiko, additional, Kobata, Tatsuro, additional, Fukushima, Nobuyoshi, additional, Ohara, Yukio, additional, Muro, Toyokichi, additional, Takesaki, Eiichi, additional, Takaki, Hitoshi, additional, Yamamoto, Tetsuo, additional, Kato, Michio, additional, Nagaoki, Yuko, additional, Hayashi, Shigeki, additional, Ishida, Jinya, additional, Watanabe, Yukio, additional, Kobayashi, Masakazu, additional, Koga, Michiaki, additional, Saoshiro, Takeo, additional, Yagura, Michiyasu, additional, Hirata, Keisuke, additional, Tanaka, Atsushu, additional, Takikawa, Hajime, additional, Zeniya, Mikio, additional, Abe, Masanori, additional, Onji, Morikazu, additional, Kaneko, Shuichi, additional, Honda, Masao, additional, Arai, Kuniaki, additional, Arinaga-Hino, Teruko, additional, Hashimoto, Etsuko, additional, Taniai, Makiko, additional, Umemura, Takeji, additional, Joshita, Satoru, additional, Nakao, Kazuhiko, additional, Ichikawa, Tatsuki, additional, Shibata, Hidetaka, additional, Yamagiwa, Satoshi, additional, Seike, Masataka, additional, Honda, Koichi, additional, Sakisaka, Shotaro, additional, Takeyama, Yasuaki, additional, Harada, Masaru, additional, Senju, Michio, additional, Yokosuka, Osamu, additional, Kanda, Tatsuo, additional, Ueno, Yoshiyuki, additional, Kikuchi, Kentaro, additional, Ebinuma, Hirotoshi, additional, Himoto, Takashi, additional, Yasunami, Michio, additional, Murata, Kazumoto, additional, Mizokami, Masashi, additional, Kawata, Kazuhito, additional, Shimoda, Shinji, additional, Miyake, Yasuhiro, additional, Takaki, Akinobu, additional, Yamamoto, Kazuhide, additional, Hirano, Katsuji, additional, Ichida, Takafumi, additional, Ido, Akio, additional, Tsubouchi, Hirohito, additional, Chayama, Kazuaki, additional, Harada, Kenichi, additional, Nakanuma, Yasuni, additional, Maehara, Yoshihiko, additional, Taketomi, Akinobu, additional, Shirabe, Ken, additional, Soejima, Yuji, additional, Mori, Akira, additional, Yagi, Shintaro, additional, Uemoto, Shinji, additional, H, Egawa, additional, Tanaka, Tomohiro, additional, Yamashiki, Noriyo, additional, Tamura, Sumito, additional, Sugawara, Yasuhiro, additional, Kokudo, Norihiro, additional, Chalasani, Naga, additional, Luketic, Vel, additional, Odin, Joseph, additional, Chopra, Kapil, additional, Abecasis, Goncalo, additional, Cantor, Michael, additional, Coppola, Giovanni, additional, Economides, Aris, additional, Lotta, Luca A., additional, Overton, John D., additional, Reid, Jeffrey G., additional, Shuldiner, Alan, additional, Beechert, Christina, additional, Forsythe, Caitlin, additional, Fuller, Erin D., additional, Gu, Zhenhua, additional, Lattari, Michael, additional, Lopez, Alexander, additional, Schleicher, Thomas D., additional, Padilla, Maria Sotiropoulos, additional, Toledo, Karina, additional, Widom, Louis, additional, Wolf, Sarah E., additional, Pradhan, Manasi, additional, Manoochehri, Kia, additional, Ulloa, Ricardo H., additional, Bai, Xiaodong, additional, Balasubramanian, Suganthi, additional, Barnard, Leland, additional, Blumenfeld, Andrew, additional, Eom, Gisu, additional, Habegger, Lukas, additional, Hawes, Alicia, additional, Khalid, Shareef, additional, Maxwell, Evan K., additional, Salerno, William, additional, Staples, Jeffrey C., additional, Jones, Marcus B., additional, Mitnaul, Lyndon J., additional, Sturgess, Richard, additional, Healey, Christopher, additional, Yeoman, Andrew, additional, Gunasekera, Anton VJ., additional, Kooner, Paul, additional, Kapur, Kapil, additional, Sathyanarayana, V., additional, Kallis, Yiannis, additional, Subhani, Javaid, additional, Harvey, Rory, additional, McCorry, Roger, additional, Rooney, Paul, additional, Ramanaden, David, additional, Evans, Richard, additional, Mathialahan, Thiriloganathan, additional, Gasem, Jaber, additional, Shorrock, Christopher, additional, Bhalme, Mahesh, additional, Southern, Paul, additional, Tibble, Jeremy A., additional, Gorard, David A., additional, Jones, Susan, additional, Mells, George, additional, Mulcahy, Victoria, additional, Srivastava, Brijesh, additional, Foxton, Matthew R., additional, Collins, Carole E., additional, Elphick, David, additional, Karmo, Mazn, additional, Porras-Perez, Francisco, additional, Mendall, Michael, additional, Yapp, Tom, additional, Patel, Minesh, additional, Ede, Roland, additional, Sayer, Joanne, additional, Jupp, James, additional, Fisher, Neil, additional, Carter, Martyn J., additional, Koss, Konrad, additional, Shah, Jayshri, additional, Piotrowicz, Andrzej, additional, Scott, Glyn, additional, Grimley, Charles, additional, Gooding, Ian R., additional, Williams, Simon, additional, Tidbury, Judith, additional, Lim, Guan, additional, Cheent, Kuldeep, additional, Levi, Sass, additional, Mansour, Dina, additional, Beckley, Matilda, additional, Hollywood, Coral, additional, Wong, Terry, additional, Marley, Richard, additional, Ramage, John, additional, Gordon, Harriet M., additional, Ridpath, Jo, additional, Ngatchu, Theodore, additional, Bob Grover, Vijay Paul, additional, Shidrawi, Ray G., additional, Abouda, George, additional, Corless, L., additional, Narain, Mark, additional, Rees, Ian, additional, Brown, Ashley, additional, Taylor-Robinson, Simon, additional, Wilkins, Joy, additional, Grellier, Leonie, additional, Banim, Paul, additional, Das, Debasish, additional, Heneghan, Michael A., additional, Curtis, Howard, additional, Matthews, Helen C., additional, Mohammed, Faiyaz, additional, Aldersley, Mark, additional, Srirajaskanthan, Raj, additional, Walker, Giles, additional, McNair, Alistair, additional, Sharif, Amar, additional, Sen, Sambit, additional, Bird, George, additional, Prince, Martin I., additional, Prasad, Geeta, additional, Kitchen, Paul, additional, Barnardo, Adrian, additional, Oza, Chirag, additional, Sivaramakrishnan, Nurani N., additional, Gupta, Prakash, additional, Shah, Amir, additional, Evans, Chris DJ., additional, Saha, Subrata, additional, Pollock, Katharine, additional, Bramley, Peter, additional, Mukhopadhya, Ashis, additional, Barclay, Stephen T., additional, McDonald, Natasha, additional, Bathgate, Andrew J., additional, Palmer, Kelvin, additional, Dillon, John F., additional, Rushbrook, Simon M., additional, Przemioslo, Robert, additional, McDonald, Chris, additional, Millar, Andrew, additional, Tai, Cheh, additional, Mitchell, Stephen, additional, Metcalf, Jane, additional, Shaukat, Syed, additional, Ninkovic, Mary, additional, Shmueli, Udi, additional, Davis, Andrew, additional, Naqvi, Asifabbas, additional, Lee, Tom JW., additional, Ryder, Stephen, additional, Collier, Jane, additional, Klass, Howard, additional, Cramp, Matthew E., additional, Sharer, Nichols, additional, Aspinall, Richard, additional, Ghosh, Deb, additional, Douds, Andrew C., additional, Booth, Jonathan, additional, Williams, Earl, additional, Hussaini, Hyder, additional, Christie, John, additional, Mann, Steven, additional, Thorburn, Douglas, additional, Marshall, Aileen, additional, Patanwala, Imran, additional, Ala, Aftab, additional, Maltby, Julia, additional, Matthew, Ray, additional, Corbett, Chris, additional, Vyas, Sam, additional, Singhal, Saket, additional, Gleeson, Dermot, additional, Misra, Sharat, additional, Butterworth, Jeff, additional, George, Keith, additional, Harding, Tim, additional, Douglass, Andrew, additional, Mitchison, Harriet, additional, Panter, Simon, additional, Shearman, Jeremy, additional, Bray, Gary, additional, Roberts, Michael, additional, Butcher, Graham, additional, Forton, Daniel, additional, Mahmood, Zahid, additional, Cowan, Matthew, additional, Das, Debashis, additional, Ch’ng, Chin Lye, additional, Rahman, Mesbah, additional, Whatley, Gregory C.A., additional, Wesley, Emma, additional, Mandal, Aditya, additional, Jain, Sanjiv, additional, Pereira, Stephen P., additional, Wright, Mark, additional, Trivedi, Palak, additional, Gordon, Fiona H., additional, Unitt, Esther, additional, Palejwala, Altaf, additional, Austin, Andrew, additional, Vemala, Vishwaraj, additional, Grant, Allister, additional, Higham, Andrew D., additional, Brind, Alison, additional, Mathew, Ray, additional, Cox, Mark, additional, Ramakrishnan, Subramaniam, additional, King, Alistair, additional, Whalley, Simon, additional, Fraser, Jocelyn, additional, Thomson, S.J., additional, Bell, Andrew, additional, Wong, Voi Shim, additional, Kia, Richard, additional, Gee, Ian, additional, Keld, Richard, additional, Ransford, Rupert, additional, Gotto, James, additional, and Millson, Charles, additional
Published: 2021
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84. The Immunophysiology and Apoptosis of Biliary Epithelial Cells: Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis

Author: Kawata, Kazuhito, Kobayashi, Yoshimasa, Gershwin, M. Eric, and Bowlus, Christopher L.
Published: 2012
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85. Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report

Author: Takeuchi, Yu, primary, Noritake, Hidenao, additional, Matsumoto, Moe, additional, Umemura, Masahiro, additional, Yamashita, Maho, additional, Kitsugi, Kensuke, additional, Takatori, Shingo, additional, Ohta, Kazuyoshi, additional, Ito, Jun, additional, Shimoyama, Shin, additional, Kaysuya, Akira, additional, Maruyama, Chiaki, additional, Fukuchi, Kensuke, additional, Dohtan, Satoshi, additional, Sakata, Hiroe, additional, and Kawata, Kazuhito, additional
Published: 2021
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86. Adverse events as potential predictive factors of activity in patients with advanced hepatocellular carcinoma treated with lenvatinib

Author: Rapposelli, Ilario Giovanni, primary, Tada, Toshifumi, additional, Shimose, Shigeo, additional, Burgio, Valentina, additional, Kumada, Takashi, additional, Iwamoto, Hideki, additional, Hiraoka, Atsushi, additional, Niizeki, Takashi, additional, Atsukawa, Masanori, additional, Koga, Hironori, additional, Hirooka, Masashi, additional, Torimura, Takuji, additional, Iavarone, Massimo, additional, Tortora, Raffaella, additional, Campani, Claudia, additional, Lonardi, Sara, additional, Tamburini, Emiliano, additional, Piscaglia, Fabio, additional, Masi, Gianluca, additional, Cabibbo, Giuseppe, additional, Giuseppe Foschi, Francesco, additional, Silletta, Marianna, additional, Tsuji, Kunihiko, additional, Ishikawa, Toru, additional, Takaguchi, Koichi, additional, Kariyama, Kazuya, additional, Itobayashi, Ei, additional, Tajiri, Kazuto, additional, Shimada, Noritomo, additional, Shibata, Hiroshi, additional, Ochi, Hironori, additional, Yasuda, Satoshi, additional, Toyoda, Hidenori, additional, Fukunishi, Shinya, additional, Ohama, Hideko, additional, Kawata, Kazuhito, additional, Tani, Joji, additional, Nakamura, Shinichiro, additional, Nouso, Kazuhiro, additional, Tsutsui, Akemi, additional, Nagano, Takuya, additional, Tanaka, Takaaki, additional, Itokawa, Norio, additional, Okubo, Tomomi, additional, Arai, Taeang, additional, Imai, Michitaka, additional, Joko, Kouji, additional, Koizumi, Yohei, additional, Hiasa, Yoichi, additional, Rimini, Margherita, additional, Ratti, Francesca, additional, Aldrighetti, Luca, additional, Cascinu, Stefano, additional, and Casadei‐Gardini, Andrea, additional
Published: 2021
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87. Impact of Modified Albumin–Bilirubin Grade on Survival in Patients With HCC Who Received Lenvatinib: An Analysis Using Time-Dependent ROC

Author: Tada, Toshifumi, primary, Kumada, Takashi, additional, Hiraoka, Atsushi, additional, Atsukawa, Masanori, additional, Hirooka, Masashi, additional, Tsuji, Kunihiko, additional, Ishikawa, Toru, additional, Takaguchi, Koichi, additional, Kariyama, Kazuya, additional, Itobayashi, Ei, additional, Tajiri, Kazuto, additional, Shimada, Noritomo, additional, Shibata, Hiroshi, additional, Ochi, Hironori, additional, Yasuda, Satoshi, additional, Toyoda, Hidenori, additional, Fukunishi, Shinya, additional, Ohama, Hideko, additional, Kawata, Kazuhito, additional, Tani, Joji, additional, Nakamura, Shinichiro, additional, Nouso, Kazuhiro, additional, Tsutsui, Akemi, additional, Nagano, Takuya, additional, Takaaki, Tanaka, additional, Itokawa, Norio, additional, Okubo, Tomomi, additional, Arai, Taeang, additional, Imai, Michitaka, additional, Joko, Kouji, additional, Koizumi, Yohei, additional, and Hiasa, Yoichi, additional
Published: 2021
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88. Hemorrhagic radiation gastritis successfully treated with repeated intra-arterial steroid infusions

Author: Kawata, Kazuhito, Kobayashi, Yoshimasa, Souda, Kenichi, Kawamura, Kinya, Takahashi, Yurimi, Noritake, Hidenao, Watanabe, Shinya, Suehiro, Tomoyuki, Kamiya, Mika, Yamashita, Shuhei, Ushio, Takasuke, and Nakamura, Hirotoshi
Published: 2011
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89. Relationship of Atezolizumab plus Bevacizumab Treatment with Muscle Volume Loss in Unresectable Hepatocellular Carcinoma Patients: Multicenter Analysis

Author: Hiraoka, Atsushi, Kumada, Takashi, Tada, Toshifumi, Hirooka, Masashi, Kariyama, Kazuya, Tani, Joji, Atsukawa, Masanori, Takaguchi, Koichi, Itobayashi, Ei, Fukunishi, Shinya, Tsuji, Kunihiko, Ishikawa, Toru, Tajiri, Kazuto, Ochi, Hironori, Yasuda, Satoshi, Toyoda, Hidenori, Ogawa, Chikara, Nishimura, Takashi, Hatanaka, Takeshi, Kakizaki, Satoru, Shimada, Noritomo, Kawata, Kazuhito, Naganuma, Atsushi, Kaibori, Masaki, Tanaka, Takaaki, Ohama, Hideko, Nouso, Kazuhiro, Morishita, Asahiro, Tsutsui, Akemi, Nagano, Takuya, Itokawa, Norio, Okubo, Tomomi, Arai, Taeang, Imai, Michitaka, Koizumi, Yohei, Nakamura, Shinichiro, Joko, Kouji, Iijima, Hiroko, Kosaka, Hisashi, Hiasa, Yoichi, and Kudo, Masatoshi
Abstract: Background/Aim:There is no known report regarding the relationship of atezolizumab plus bevacizumab (Atez/Bev) treatment with muscle volume loss (MVL) in unresectable hepatocellular carcinoma (u-HCC) patients. This study aimed to elucidate the clinical relationship between MVL and Atez/Bev. Materials/Methods:From September 2020 to December 2021, 229 u-HCC patients treated with Atez/Bev and with muscle volume data obtained by computed tomography at the baseline available were analyzed (median age, 74 years; males, 186 (81.2%); ECOG PS 0/1, 221 (96.5%); HCV:HBV:alcohol:others = 81:33:40:75; Child-Pugh A, 212 (92.6%); modified albumin-bilirubin (mALBI) grade 1:2a:2b = 79:60:90; BCLC 0:A:B:C = 1:24:87:117; median observation period, 6.8 months). Japan Society of Hepatology criteria were used for definition of MVL and prognostic factors were retrospectively evaluated. Results:Multivariate Cox-hazard analysis of prognostic factors for progression-free survival (PFS) showed elevated alpha-fetoprotein (AFP) (≥100 ng/mL) (HR 1.848, 95% CI 1.264–2.702, p= 0.002), mALBI grade (≥2a) (HR 1.563, 95% CI 1.035–2.359, p= 0.034), and MVL (HR 1.479, 95% CI 1.020–2.144, p= 0.039) as significant factors. For overall survival (OS), significant factors included elevated AFP (≥100 ng/mL) (HR 3.564, 95% CI 1.856–6.844, p< 0.001), mALBI grade (≥2a) (HR 3.451, 95% CI 1.580–7.538, p= 0.002), and MVL (HR 2.119, 95% CI 1.150–3.904, p= 0.016). Patients with MVL (MVL group, n= 91) showed worse PFS than those without (non-MVL group, n= 138) (median PFS 5.3 vs. 7.6 months, p= 0.025), while the MVL group showed worse OS (p= 0.038), though neither reached the median survival time. Conclusion:MVL may be a clinical factor related to poor prognosis in patients receiving Atez/Bev treatment for u-HCC.
Published: 2022
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90. Glasgow prognostic score predicts survival in patients with unresectable hepatocellular carcinoma treated with lenvatinib: a multicenter analysis.

Author: Tada, Toshifumi, Kumada, Takashi, Hiraoka, Atsushi, Hirooka, Masashi, Kariyama, Kazuya, Tani, Joji, Atsukawa, Masanori, Takaguchi, Koichi, Itobayashi, Ei, Fukunishi, Shinya, Tsuji, Kunihiko, Ishikawa, Toru, Tajiri, Kazuto, Ochi, Hironori, Yasuda, Satoshi, Toyoda, Hidenori, Hatanaka, Takeshi, Kakizaki, Satoru, Shimada, Noritomo, and Kawata, Kazuhito
Published: 2022
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91. Efficacy of Lenvatinib for Unresectable Hepatocellular Carcinoma Based on Background Liver Disease Etiology: Multi-center Retrospective Study

Author: Hiraoka, Atsushi, primary, Kumada, Takashi, additional, Tada, Toshifumi, additional, Tani, Joji, additional, Kariyama, Kazuya, additional, Fukunishi, Shinya, additional, Atsukawa, Masanori, additional, Hirooka, Masashi, additional, Tsuji, Kunihiko, additional, Ishikawa, Toru, additional, Takaguchi, Koichi, additional, Itobayashi, Ei, additional, Tajiri, Kazuto, additional, Shimada, Noritomo, additional, Shibata, Hiroshi, additional, Ochi, Hironori, additional, Kawata, Kazuhito, additional, Yasuda, Satoshi, additional, Toyoda, Hidenori, additional, Aoki, Tomoko, additional, Tanaka, Takaaki, additional, Ohama, Hideko, additional, Nouso, Kazuhiro, additional, Tsutsui, Akemi, additional, Nagano, Takuya, additional, Itokawa, Norio, additional, Arai, Taeang, additional, Okubo, Tomomi, additional, Imai, Michitaka, additional, Koizumi, Yohei, additional, Nakamura, Shinichiro, additional, Joko, Koji, additional, Hiasa, Yoichi, additional, and Kudo, Masatoshi, additional
Published: 2021
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92. SAT-448 - Serum levels of type IV collagen 7S can predict liver-related mortality and events as well as advanced fibrosis: a multi-center study

Author: Ishiba, Hiroshi, Sumida, Yoshio, Kamada, Yoshihiro, Fujii, Hideki, Iwaki, Michihiro, Hayashi, Hideki, Toyoda, Hidenori, Oeda, Satoshi, Hyogo, Hideyuki, Kawanaka, Miwa, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Tsutsumi, Tsubasa, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, Araraki, Shingo, Kawaguchi, Takumi, Noritake, Hiedenao, Ono, Masafumi, Masaki, Tsutomu, Yasuda, Satoshi, Tomita, Eiichi, Yoneda, Masato, Tokushige, Akihiro, Takahashi, Hirokazu, Ueda, Shinichiro, Nakajima, Atsushi, and Okanoue, Takeshi
Published: 2023
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93. THU-131 - Incidence and risk factors of esophagogastric varices bleeding in patients with advanced hepatocellular carcinoma treated with lenvatinib

Author: Iavarone, Massimo, Alimenti, Eleonora, Tada, Toshifumi, Shigeo, Shimose, Suda, Goki, Yoo, Changhoon, Soldà, Caterina, Piscaglia, Fabio, Gardini, Andrea Casadei, Marra, Fabio, Vivaldi, Caterina, Conti, Fabio, Schirripa, Marta, Iwamoto, Hideki, Sho, Takuya, Leo, So Heun, Rizzato, Mario Domenico, Tonnini, Matteo, Rimini, Margherita, Campani, Claudia, Masi, Gianluca, Foschi, Francesco, Bruccoleri, Mariangela, Kawaguchi, Takumi, Kumada, Takashi, Hiraoka, Atsushi, Atsukawa, Masanori, Fukunishi, Shinya, Ishikawa, Toru, Tajiri, Kazuto, Ochi, Hironori, Yasuda, Satoshi, Toyoda, Hidenori, Hatanaka, Takeshi, Kakizaki, Satoru, Kawata, Kazuhito, Tada, Faujimasa, Ohama, Hideko, Itokawa, Norio, Okubo, Tomomi, Arai, Taeang, Imai, Michitaka, Naganuma, Atsushi, Tosetti, Giulia, and Lampertico, Pietro
Published: 2023
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94. WED-293 - Prognostic value of serum ALP levels during additional treatment in Japanese patients with primary biliary cholangitis treated with ursodeoxycholic acid and bezafibrate

Author: Takeuchi, Akihito, Matsumoto, Kosuke, Komori, Atsumasa, Abe, Masanori, Namisaki, Tadashi, Kawata, Kazuhito, Ninomiya, Masashi, Fujii, Hideki, Takahashi, Atsushi, Jong-Hon, KANG, Takamura, Masaaki, Arakawa, Mie, Joshita, Satoru, Sato, Ken, Nomura, Takako, Kakisaka, Keisuke, Kaneko, Akira, Kikuchi, Kentaro, Masaki, Tsutomu, Umemura, Takeji, Honda, Akira, Ohira, Hiromasa, Kawada, Norifumi, Yoshiji, Hitoshi, Mochida, Satoshi, and Tanaka, Atsushi
Published: 2023
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95. Common Drug Pipelines for the Treatment of Diabetic Nephropathy and Hepatopathy: Can We Kill Two Birds with One Stone?

Author: Sumida, Yoshio, Yoneda, Masashi, Toyoda, Hidenori, Yasuda, Satoshi, Tada, Toshifumi, Hayashi, Hideki, Nishigaki, Yoichi, Suzuki, Yusuke, Naiki, Takafumi, Morishita, Asahiro, Tobita, Hiroshi, Sato , Shuichi, Kawabe, Naoto, Fukunishi , Shinya, Ikegami, Tadashi, Kessoku, Takaomi, Ogawa, Yuji, Honda, Yasushi, Nakahara, Takashi, Munekage, Kensuke, Ochi , Tsunehiro, Sawada, Koji, Takahashi, Atsushi, Arai Taeang, Kogiso, Tomomi, Kimoto, Satoshi, Tomita, Kengo, Notsumata, Kazuo, Nonaka, Michihiro, Kawata, Kazuhito, Takami, Taro, Kumada , Takashi, Tomita, Eiichi, Okanoue, Takeshi, Nakajima, Atsushi, Sumida, Yoshio, Yoneda, Masashi, Toyoda, Hidenori, Yasuda, Satoshi, Tada, Toshifumi, Hayashi, Hideki, Nishigaki, Yoichi, Suzuki, Yusuke, Naiki, Takafumi, Morishita, Asahiro, Tobita, Hiroshi, Sato , Shuichi, Kawabe, Naoto, Fukunishi , Shinya, Ikegami, Tadashi, Kessoku, Takaomi, Ogawa, Yuji, Honda, Yasushi, Nakahara, Takashi, Munekage, Kensuke, Ochi , Tsunehiro, Sawada, Koji, Takahashi, Atsushi, Arai Taeang, Kogiso, Tomomi, Kimoto, Satoshi, Tomita, Kengo, Notsumata, Kazuo, Nonaka, Michihiro, Kawata, Kazuhito, Takami, Taro, Kumada , Takashi, Tomita, Eiichi, Okanoue, Takeshi, and Nakajima, Atsushi
Published: 2020

96. Lenvatinib versus sorafenib in first‐line treatment of unresectable hepatocellular carcinoma: An inverse probability of treatment weighting analysis

Author: Casadei‐Gardini, Andrea, primary, Scartozzi, Mario, additional, Tada, Toshifumi, additional, Yoo, Changhoon, additional, Shimose, Shigeo, additional, Masi, Gianluca, additional, Lonardi, Sara, additional, Frassineti, Luca Giovanni, additional, Nicola, Silvestris, additional, Piscaglia, Fabio, additional, Kumada, Takashi, additional, Kim, Hyung‐Don, additional, Koga, Hironori, additional, Vivaldi, Caterina, additional, Soldà, Caterina, additional, Hiraoka, Atsushi, additional, Bang, Yeonghak, additional, Atsukawa, Masanori, additional, Torimura, Takuji, additional, Tsuj, Kunihiko, additional, Itobayashi, Ei, additional, Toyoda, Hidenori, additional, Fukunishi, Shinya, additional, Rimassa, Lorenza, additional, Rimini, Margherita, additional, Cascinu, Stefano, additional, Cucchetti, Alessandro, additional, Nakamura, Shinichiro, additional, Michitaka, Kojiro, additional, Itokawa, Norio, additional, Hayama, Korenobu, additional, Hirooka, Masashi, additional, Koizumi, Yohei, additional, Hiasa, Yoichi, additional, Ishikawa, Toru, additional, Imai, Michitaka, additional, Takaguchi, Koichi, additional, Tsutsui, Akemi, additional, Nagano, Takuya, additional, Kariyama, Kazuya, additional, Nouso, Kazuhiro, additional, Tajiri, Kazuto, additional, Shimada, Noritomo, additional, Shibata, Hiroshi, additional, Ochi, Hironori, additional, Joko, Kouji, additional, Yasuda, Satoshi, additional, Ohama, Hideko, additional, and Kawata, Kazuhito, additional
Published: 2021
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97. Giant Hepatomegaly with Spleno-testicular Enlargement in a Patient with Apolipoprotein A-I Amyloidosis: An Uncommon Type of Amyloidosis in Japan

Author: Yoshinaga, Tsuneaki, primary, Katoh, Nagaaki, additional, Yazaki, Masahide, additional, Sato, Mitsuto, additional, Kametani, Fuyuki, additional, Yasuda, Hideo, additional, Watanabe, Kyohei, additional, Kawata, Kazuhito, additional, Nakagawa, Mayuko, additional, and Sekijima, Yoshiki, additional
Published: 2021
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98. The ursodeoxycholic acid response score predicts pathological features in primary biliary cholangitis

Author: Kawata, Kazuhito, primary, Joshita, Satoru, additional, Shimoda, Shinji, additional, Yamashita, Yuki, additional, Yamashita, Maho, additional, Kitsugi, Kensuke, additional, Takatori, Shingo, additional, Ohta, Kazuyoshi, additional, Ito, Jun, additional, Shimoyama, Shin, additional, Noritake, Hidenao, additional, Suda, Takafumi, additional, and Harada, Kenichi, additional
Published: 2020
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99. Clonality, Activated Antigen-Specific Cd8+ T Cells, And Development of Autoimmune Cholangitis in DntgfβRii Mice

Author: Kawata, Kazuhito, Yang, Guo-Xiang, Ando, Yugo, Tanaka, Hajime, Zhang, Weici, Kobayashi, Yoshimasa, Tsuneyama, Koichi, Leung, Patrick S.C., Lian, Zhe-Xiong, Ridgway, William M., Ansari, Aftab A., He, Xiao-Song, and Gershwin, Eric M.
Published: 2013
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100. Deletion of Interleukin (IL)-12p35 Induces Liver Fibrosis in Dominant-Negative TGFβ Receptor Type II Mice

Author: Tsuda, Masanobu, Zhang, Weici, Yang, Guo-Xiang, Tsuneyama, Koichi, Ando, Yugo, Kawata, Kazuhito, Park, Ogyi, Leung, Patrick S.C., Coppel, Ross L., Ansari, Aftab A., Ridgway, William M., Gao, Bin, Lian, Zhe-Xiong, Flavell, Richard, He, Xiao-Song, and Gershwin, Eric M.
Published: 2013
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