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51. Cardiomyocyte microRNA-150 confers cardiac protection and directly represses proapoptotic small proline–rich protein 1A

Author

Aonuma, Tatsuya, primary, Moukette, Bruno, additional, Kawaguchi, Satoshi, additional, Barupala, Nipuni P., additional, Sepúlveda, Marisa N., additional, Corr, Christopher, additional, Tang, Yaoliang, additional, Liangpunsakul, Suthat, additional, Payne, R. Mark, additional, Willis, Monte S., additional, and Kim, Il-man, additional

Published
2021
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53. Total Anomalous Pulmonary Venous Connection with Lethal Pulmonary Venous Obstruction Managed by Multidisciplinary Cooperation

Author

Ito, Kana, Chida-Nagai, Ayako, Sasaki, Osamu, Kato, Nobuyasu, Umazume, Takeshi, Kawaguchi, Satoshi, Cho, Kazutoshi, Izumi, Gaku, Yamazawa, Hirokuni, and Takeda, Atsuhito

Subjects
Article Subject
Abstract

Background. Total anomalous pulmonary venous connection (TAPVC) is a critical congenital heart disease for which emergency surgery is required after birth. In cases of no intervention, TAPVC is associated with a high mortality rate in the first year of life. Although foetal echocardiographic techniques for diagnosing TAPVC have improved, TAPVC remains one of the most difficult congenital heart diseases to diagnose via foetal echocardiography. Here, we report a case of TAPVC with pulmonary venous obstruction (PVO), which was diagnosed via foetal echocardiography. Case Presentation. On foetal echocardiography at 32 weeks’ gestation, a large atrial septal defect, enlarged superior vena cava, and continuous flow pattern in the vertical vein from the common chamber were observed in the foetus. Paediatric cardiologists and cardiac surgeons, neonatologists, and obstetricians planned to perform a caesarean section and emergency heart surgery. The male infant was born at 37 weeks’ gestation via caesarean section, and postnatal echocardiography revealed PVO at the confluence of the superior vena cava and common chamber. Similarly, chest computed tomography confirmed the foetal diagnosis. The postnatal diagnoses were TAPVC type Ib, PVO, atrial septal defect, and patent ductus arteriosus. Surgical repair of the TAPVC was initiated within the first 3 hours of life. Screening brain echocardiography and head computed tomography revealed intracranial haemorrhage and hydrocephalus. Therefore, the patient underwent emergency bilateral external drainage on day 13. On day 48, a ventriculoperitoneal shunt was inserted owing to progressive brain ventricular dilatation. The patient was discharged home on postoperative day 68. Conclusions. Although the prognosis of TAPVC with PVO remains poor, continuous observation through foetal echocardiography and early interdepartmental collaboration can result in good outcomes.

Published
2021
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64. Glycemic control and fetal growth of women with diabetes mellitus and subsequent hypertensive disorders of pregnancy

Author

1000000374380, Morikawa, Mamoru, Kato-Hirayama, Emi, Mayama, Michinori, Saito, Yoshihiro, Nakagawa, Kinuko, 1000000807935, Umazume, Takeshi, Chiba, Kentaro, Kawaguchi, Satoshi, 1000040214085, Okuyama, Kazuhiko, 1000010344508, Watari, Hidemichi, 1000000374380, Morikawa, Mamoru, Kato-Hirayama, Emi, Mayama, Michinori, Saito, Yoshihiro, Nakagawa, Kinuko, 1000000807935, Umazume, Takeshi, Chiba, Kentaro, Kawaguchi, Satoshi, 1000040214085, Okuyama, Kazuhiko, 1000010344508, and Watari, Hidemichi

Abstract

Pregnant women with diabetes mellitus (DM) are at high risk for hypertensive disorder of pregnancy (HDP). Women with poor control DM sometimes have heavy-for-dates infants. However, women with HDP sometimes have light-for-dates infants. We aim to clarify the relationship between glycemic control and fetal growth in women with DM and/or subsequent HDP. Of 7893 women gave singleton birth at or after 22 gestational weeks, we enrolled 154 women with type 1 DM (T1DM) or type 2 DM (T2DM) whose infants did not have fetal abnormalities. Among women with T1DM or T2DM, characteristics of the three groups (with HDP, without HDP, and with chronic hypertension [CH]) were compared. No women with T1DM had CH, but 19 (17.4%) of 109 with T2DM did. HDP incidence was similar between women with T1DM (22.2%) and T2DM without CH (16.7%). Among women with T1DM, the incidences of fetal growth restriction (FGR) with and without HDP were similar. However, among women with T2DM without CH, this incidence was significantly higher among those with HDP (33.3%) than among those without HDP (5.3%), was significantly more common with HbA1c levels at first trimester. 7.2% (33.3%) than with those < 7.2% (5.6%), and significantly more numerous without pre-pregnancy therapies for DM (23.3%) than with them (3.3%). Among women with T2DM and HDP, those with FGR had smaller placenta SDs and higher insulin dosages at delivery than those without light-for-dates. In multivariate analysis, the presence of diabetic nephropathy was a predictor of T1DM and HDP (P = 0.0105), whereas HbA1c levels >= 7.2% before pregnancy was a predictor of T2DM and HDP (P = 0.0009). Insulin dosage > 50U/day at delivery (P = 0.0297) and the presence of HDP (P = 0.0116) independently predicted T2DM, HDP, and FGR development. Insufficient pre-pregnancy treatment of DM increased the risk of HDP.

Published
2020

65. Glycemic control and fetal growth of women with diabetes mellitus and subsequent hypertensive disorders of pregnancy

Author

Morikawa, Mamoru, Kato-Hirayama, Emi, Mayama, Michinori, Saito, Yoshihiro, Nakagawa, Kinuko, Umazume, Takeshi, Chiba, Kentaro, Kawaguchi, Satoshi, Okuyama, Kazuhiko, Watari, Hidemichi, Morikawa, Mamoru, Kato-Hirayama, Emi, Mayama, Michinori, Saito, Yoshihiro, Nakagawa, Kinuko, Umazume, Takeshi, Chiba, Kentaro, Kawaguchi, Satoshi, Okuyama, Kazuhiko, and Watari, Hidemichi

Abstract

Pregnant women with diabetes mellitus (DM) are at high risk for hypertensive disorder of pregnancy (HDP). Women with poor control DM sometimes have heavy-for-dates infants. However, women with HDP sometimes have light-for-dates infants. We aim to clarify the relationship between glycemic control and fetal growth in women with DM and/or subsequent HDP. Of 7893 women gave singleton birth at or after 22 gestational weeks, we enrolled 154 women with type 1 DM (T1DM) or type 2 DM (T2DM) whose infants did not have fetal abnormalities. Among women with T1DM or T2DM, characteristics of the three groups (with HDP, without HDP, and with chronic hypertension [CH]) were compared. No women with T1DM had CH, but 19 (17.4%) of 109 with T2DM did. HDP incidence was similar between women with T1DM (22.2%) and T2DM without CH (16.7%). Among women with T1DM, the incidences of fetal growth restriction (FGR) with and without HDP were similar. However, among women with T2DM without CH, this incidence was significantly higher among those with HDP (33.3%) than among those without HDP (5.3%), was significantly more common with HbA1c levels at first trimester. 7.2% (33.3%) than with those < 7.2% (5.6%), and significantly more numerous without pre-pregnancy therapies for DM (23.3%) than with them (3.3%). Among women with T2DM and HDP, those with FGR had smaller placenta SDs and higher insulin dosages at delivery than those without light-for-dates. In multivariate analysis, the presence of diabetic nephropathy was a predictor of T1DM and HDP (P = 0.0105), whereas HbA1c levels >= 7.2% before pregnancy was a predictor of T2DM and HDP (P = 0.0009). Insulin dosage > 50U/day at delivery (P = 0.0297) and the presence of HDP (P = 0.0116) independently predicted T2DM, HDP, and FGR development. Insufficient pre-pregnancy treatment of DM increased the risk of HDP.

Published
2020

68. Acute Myocardial Infarction in a 17-year-old High-school Girl

Author

Kawaguchi, Satoshi, primary, Hasebe, Tomomi, additional, Ohta, Hisanobu, additional, Kikuchi, Asami, additional, Asanome, Akira, additional, Nishiura, Takeshi, additional, Sakamoto, Naka, additional, Tanabe, Yasuko, additional, Takeuchi, Toshiharu, additional, Sato, Nobuyuki, additional, Kawamura, Yuichiro, additional, and Hasebe, Naoyuki, additional

Published
2021
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78. SYT-SSX breakpoint peptide vaccines in patients with synovial sarcoma: A study from the Japanese Musculoskeletal Oncology Group

Author

Kawaguchi, Satoshi, Tsukahara, Tomohide, Ida, Kazunori, Kimura, Shigeharu, Murase, Masaki, Kano, Masanobu, Emori, Makoto, Nagoya, Satoshi, Kaya, Mitsunori, Torigoe, Toshihiko, Ueda, Emiri, Takahashi, Akari, Ishii, Takeshi, Tatezaki, Shin-ichiro, Toguchida, Junya, Tsuchiya, Hiroyuki, Osanai, Toshihisa, Sugita, Takashi, Sugiura, Hideshi, Ieguchi, Makoto, Ihara, Koichiro, Hamada, Ken-ichiro, Kakizaki, Hiroshi, Morii, Takeshi, Yasuda, Taketoshi, Tanizawa, Taisuke, Ogose, Akira, Yabe, Hiroo, Yamashita, Toshihiko, Sato, Noriyuki, and Wada, Takuro

Published
2012
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88. Development of an Intelligent Power Module Inserter

Author

Sato, Junya, primary, Ichikawa, Yoshiaki, additional, Yamada, Takayoshi, additional, Ito, Kazuaki, additional, Yamamoto, Hidehiko, additional, Fujihara, Motoharu, additional, Kawaguchi, Satoshi, additional, Suzuki, Takehiko, additional, and Izawa, Jin, additional

Published
2020
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