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346 results on '"Karonen, Maarit"'

54. Bioactive Properties of the Aqueous Extracts of Endophytic Fungi Associated with Scots Pine (Pinus sylvestris) Roots

Author

Tienaho, Jenni, additional, Karonen, Maarit, additional, Muilu-Mäkelä, Riina, additional, Kaseva, Janne, additional, de Pedro, Nuria, additional, Vicente, Francisca, additional, Genilloud, Olga, additional, Aapola, Ulla, additional, Uusitalo, Hannu, additional, Vuolteenaho, Katriina, additional, Franzén, Robert, additional, Wähälä, Kristiina, additional, Karp, Matti, additional, Santala, Ville, additional, and Sarjala, Tytti, additional

Published
2020
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57. Ellagitannins with a glucopyranose core have higher affinity to proteins than acyclic ellagitannins by isothermal titration calorimetry

Author

Karonen, Maarit, Oraviita, Marianne, Mueller-Harvey, Irene, Salminen, Juha-Pekka, and Green, Rebecca Joanne

Abstract

The thermodynamics of the interactions of different ellagitannins with two proteins, namely bovine serum albumin (BSA) and gelatin, were studied by isothermal titration calorimetry. Twelve individual ellagitannins, including different monomers, dimers and a trimer, were used. The studies showed that several structural features affected the interaction between the ellagitannin and the protein. The interactions of ellagitannins with proteins were stronger with gelatin than with BSA. The ellagitannin-gelatin interactions contained both the primary stronger and the secondary weaker binding sites. The ellagitannin-BSA interactions showed very weak secondary interactions. The ellagitannins with a glucopyranose core had stronger interaction than C-glycosidic ellagitannins with both proteins. In addition, the observed enthalpy change increased as the degree of oligomerization increased. The stronger interactions were also observed with free galloyl groups in the ellagitannin structure and with higher molecular flexibility. Other smaller structural features did not show any overall trend.

Published
2019

59. Benefits of Condensed Tannins in Forage Legumes Fed to Ruminants: Importance of Structure, Concentration, and Diet Composition

Author

Mueller-Harvey, Irene, Bee, Giuseppe, Dohme-Meier, Frigga, Hoste, Herve, Karonen, Maarit, Koelliker, Roland, Luescher, Andreas, Niderkorn, Vincent, Pellikaan, Wilbert F., Salminen, Juha-Pekka, Skot, Leif, Smith, Lydia M. J., Thamsborg, Stig M., Totterdell, Paul, Wilkinson, Ian, Williams, Andrew R., Azuhnwi, Blasius N., Baert, Nicolas, Brinkhaus, Anja Grosse, Copani, Giuseppe, Desrues, Olivier, Drake, Chris, Engstrom, Marica, Fryganas, Christos, Girard, Marion, Huyen, Nguyen T., Kempf, Katharina, Malisch, Carsten, Mora-Ortiz, Marina, Quijada, Jessica, Ramsay, Aina, Ropiak, Honorata M., Waghorn, Garry C., Mueller-Harvey, Irene, Bee, Giuseppe, Dohme-Meier, Frigga, Hoste, Herve, Karonen, Maarit, Koelliker, Roland, Luescher, Andreas, Niderkorn, Vincent, Pellikaan, Wilbert F., Salminen, Juha-Pekka, Skot, Leif, Smith, Lydia M. J., Thamsborg, Stig M., Totterdell, Paul, Wilkinson, Ian, Williams, Andrew R., Azuhnwi, Blasius N., Baert, Nicolas, Brinkhaus, Anja Grosse, Copani, Giuseppe, Desrues, Olivier, Drake, Chris, Engstrom, Marica, Fryganas, Christos, Girard, Marion, Huyen, Nguyen T., Kempf, Katharina, Malisch, Carsten, Mora-Ortiz, Marina, Quijada, Jessica, Ramsay, Aina, Ropiak, Honorata M., and Waghorn, Garry C.

Published
2019

61. Metabolic Profiling of Water-Soluble Compounds from the Extracts of Dark Septate Endophytic Fungi (DSE) Isolated from Scots Pine (Pinus sylvestris L.) Seedlings Using UPLC–Orbitrap–MS

Author

Tienaho, Jenni, primary, Karonen, Maarit, additional, Muilu–Mäkelä, Riina, additional, Wähälä, Kristiina, additional, Leon Denegri, Eduardo, additional, Franzén, Robert, additional, Karp, Matti, additional, Santala, Ville, additional, and Sarjala, Tytti, additional

Published
2019
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62. Benefits of Condensed Tannins in Forage Legumes Fed to Ruminants: Importance of Structure, Concentration, and Diet Composition

Author

Mueller-Harvey, Irene, primary, Bee, Giuseppe, additional, Dohme-Meier, Frigga, additional, Hoste, Hervé, additional, Karonen, Maarit, additional, Kölliker, Roland, additional, Lüscher, Andreas, additional, Niderkorn, Vincent, additional, Pellikaan, Wilbert F., additional, Salminen, Juha-Pekka, additional, Skøt, Leif, additional, Smith, Lydia M.J., additional, Thamsborg, Stig M., additional, Totterdell, Paul, additional, Wilkinson, Ian, additional, Williams, Andrew R., additional, Azuhnwi, Blasius N., additional, Baert, Nicolas, additional, Brinkhaus, Anja Grosse, additional, Copani, Giuseppe, additional, Desrues, Olivier, additional, Drake, Chris, additional, Engström, Marica, additional, Fryganas, Christos, additional, Girard, Marion, additional, Huyen, Nguyen T., additional, Kempf, Katharina, additional, Malisch, Carsten, additional, Mora-Ortiz, Marina, additional, Quijada, Jessica, additional, Ramsay, Aina, additional, Ropiak, Honorata M., additional, and Waghorn, Garry C., additional

Published
2019
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66. Variability in Foliar Ellagitannins of Hippophaë rhamnoidesL. and Identification of a New Ellagitannin, Hippophaenin C

Author

Suvanto, Jussi, Tähtinen, Petri, Valkamaa, Saku, Engström, Marica T., Karonen, Maarit, and Salminen, Juha-Pekka

Abstract

Berries of common sea-buckthorn (Hippophaë rhamnoidesL.) are well-known and used for their bioactive components, and while there is a considerable amount of research on the leaves as well, their ellagitannins (ETs) have not been a prominent focus of research. We identified and quantified ten major hydrophilic polyphenols, all ETs, in H. rhamnoidesleaves and compared their abundance between 58 plant individuals. Of these compounds, hippophaenin C was characterized as a new ellagitannin by various spectrometric methods. The total concentrations of ETs ranged from 42.5 mg g–1dry weight (DW) to 109.1 mg g–1DW between individual plants. Among the ETs, hippophaenin C, stachyurin, and casuarinin were on average the most abundant compounds. Sexes did not differ significantly, while cultivars showed variation in some ETs. These results suggest that H. rhamnoidesleaves could be a potential and rich source of several ETs.

Published
2024
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67. Ellagitannins Inhibit the Exsheathment of Haemonchus contortusand Trichostrongylus colubriformisLarvae: The Efficiency Increases Together with the Molecular Size

Author

Karonen, Maarit, Ahern, Jeffrey R., Legroux, Lucie, Suvanto, Jussi, Engström, Marica T., Sinkkonen, Jari, Salminen, Juha-Pekka, and Hoste, Hervé

Abstract

Worldwide, parasitic gastrointestinal nematodes continue to threaten animal health, welfare, and production in outdoor breeding systems of small ruminants. For more than 50 years, the control of these parasitic worms has relied on the use of commercial synthetic anthelmintics. However, anthelmintic resistance in worm populations is nowadays widespread and requires novel solutions. The use of tannin-rich plants has been suggested as an alternative to synthetic anthelmintics to control gastrointestinal nematodes. The majority of previous studies have focused on the activity of proanthocyanidins (syn condensed tannins), and less is known about ellagitannins. In this study, the effects of 30 structurally unique ellagitannins on the exsheathment of third-stage infective larvae were examined on Haemonchus contortusand Trichostrongylus colubriformisby the in vitro larval exsheathment inhibition assay. Ellagitannins were found to be promising natural anthelmintics as they showed direct inhibition on larval exsheathment for both nematode species. In general, ellagitannins were more efficient at inhibiting the exsheathment of H. contortuslarvae than those of T. colubriformis. The efficiency of inhibition increased as the degree of oligomerization or the molecular weight of the ellagitannin increased. Otherwise, we found no other structural features of ellagitannins that significantly affected the anthelmintic activity on the third-stage infective larvae. The effective concentrations were physiologically relevant and should be achievable in the gastrointestinal tract also in in vivo conditions.

Published
2024
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74. A Tandem Mass Spectrometric Method for Singlet Oxygen Measurement

Author

Karonen, Maarit, Mattila, Heta, Huang, Ping, Mamedov, Fikret, Styring, Stenbjörn, Tyystjarvi, Esa, Karonen, Maarit, Mattila, Heta, Huang, Ping, Mamedov, Fikret, Styring, Stenbjörn, and Tyystjarvi, Esa

Abstract

Singlet oxygen, a harmful reactive oxygen species, can be quantified with the substance 2,2,6,6-tetramethylpiperidine (TEMP) that reacts with singlet oxygen, forming a stable nitroxyl radical (TEMPO). TEMPO has earlier been quantified with electron paramagnetic resonance (EPR) spectroscopy. In this study, we designed an ultra-high-performance liquid chromatographictandem mass spectrometric (UHPLC-ESI-MS/MS) quantification method for TEMPO and showed that the method based on multiple reaction monitoring (MRM) can be used for the measurements of singlet oxygen from both nonbiological and biological samples. Results obtained with both UHPLC-ESI-MS/MS and EPR methods suggest that plant thylakoid membranes produce 3.7x10(-7) molecules of singlet oxygen per chlorophyll molecule in a second when illuminated with the photosynthetic photon flux density of 2000molm(-2)s(-1).

Published
2014
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79. Secondary metabolite fromNostoc XPORK14A inhibits photosynthesis and growth ofSynechocystis PCC 6803

Author

SHUNMUGAM, SUMATHY, primary, JOKELA, JOUNI, additional, WAHLSTEN, MATTI, additional, BATTCHIKOVA, NATALIA, additional, REHMAN, ATEEQ UR, additional, VASS, IMRE, additional, KARONEN, MAARIT, additional, SINKKONEN, JARI, additional, PERMI, PERTTU, additional, SIVONEN, KAARINA, additional, ARO, EVA-MARI, additional, and ALLAHVERDIYEVA, YAGUT, additional

Published
2013
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81. Bitter problems in ecological feeding experiments: commercial tannin preparations and common methods for tannin quantifications

Author

Rautio, Pasi, Alm Bergvall, Ulrika, Karonen, Maarit, Salminen, Juha-Pekka, Rautio, Pasi, Alm Bergvall, Ulrika, Karonen, Maarit, and Salminen, Juha-Pekka

Abstract

In the field of plant-herbivore interactions research methods manipulating plant secondary metabolites are becoming more and more popular. In most cases food offered to herbivores is manipulated with commercially available compounds, or more specifically, compound mixtures. Among the most commonly used is tannic acid, the almost sole commercial source of hydrolysable tannins. However, recent studies have shown that different tannic acid preparations are not comparable in their tannin structures. While tannic acids are meant to contain only gallotannins (GTs), some commercial preparations compose mainly of more simple galloglucoses (that have e.g. much lower protein precipitation capacity than GTs) or even of gallic acid (the hydrolysis product of GTs). Another commonly used group of tannins used in feeding trials is condensed tannins (CTs), usually in the form of quebracho tannin. One of the problems in using quebracho is that it contains different CT structures than e.g. leaves of many deciduous trees. Additionally, when analysed with the common acid-butanol assay for total CTs, quebracho tannins give even 30-fold lower absorbance than the CTs of those deciduous trees. This dilemma is highlighted by the fact that quebracho tannin is commonly used as a standard when analysing CT concentrations in plant tissues. In addition to above problems, different herbivore species are known to react differently to varying tannin structures. Therefore, ecologically the most serious concern lies in that our commercial tannin compounds might have biological activities highly different from the tannins of our study plants. Below we discuss these problems, as well as some means to deal with them.

Published
2007
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82. Protective effect of Terminalia muelleri against carbon tetrachloride-induced hepato and nephro-toxicity in mice and characterization of its bioactive constituents.

Author

Fahmy, Nouran Mohamed, Al-Sayed, Eman, Abdel-Daim, Mohamed M., Karonen, Maarit, and Singab, Abdel Nasser

Subjects
NEPHROTOXICOLOGY, HEPATOTOXICOLOGY, TERMINALIA, COMBRETACEAE, CARBON tetrachloride, BIOACTIVE compounds, TRADITIONAL medicine, LABORATORY mice, THERAPEUTICS
Abstract

Context:Terminaliais used in folk medicine for the treatment of various diseases. Objective: The objective of this study is to investigate the hepatonephro protective activity of a polyphenol-rich fraction (TMEF) obtained fromTerminalia muelleriBenth. (Combretaceae) against CCl4-induced toxicity in mice. Materials and methods: TMEF was administered (100, 200, and 400 mg/kg/d) for 5 d. CCl4was administered at the end of the experiment. Hepatic and renal biomarkers were measured in the serum. Glutathione (GSH), superoxide dismutase (SOD), and malondialdehyde (MDA) were estimated in the liver and kidney tissues. The active constituents of TMEF were identified by HPLC–PDA–ESI/MS/MS. Results: TMEF is rich in ellagitannins, galloyl esters, phenolic acids, and flavone-C-glucosides. TMEF pretreatment significantly (p < 0.001) inhibited the CCl4-induced increase in ALT (17, 43, and 53%), AST (20, 46, and 58%), ALP (20, 48, and 56%), LDH (21, 47, and 58%), hepatic MDA (23, 49, and 54%), renal MDA (22, 35, and 52%), creatinine (48, 66, and 91%), uric acid (16, 34, and 59%), urea (22, 39, and 59%), and cholesterol (20, 27, and 46%). Furthermore, TMEF administration significantly (p < 0.001) increased hepatic GSH (15, 51, and 79%), renal GSH (23, 45, and 73%), hepatic SOD (9, 52, and 95%), renal SOD (39, 66, and 85%) and protein levels (17, 24, and 29%) at the tested doses of TMEF, respectively. Pretreatment with TMEF preserved the hepatic architecture and protected from ballooning degeneration, liver necrosis, renal inflammation, and degeneration of the kidney tubules. Conclusion: TMEF has a marked hepato-nephro protective effect. [ABSTRACT FROM PUBLISHER]

Published
2016
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95. Protective role of polyphenols from Bauhinia hookeri against carbon tetrachloride-induced hepato- and nephrotoxicity in mice.

Author

Al-Sayed, Eman, Abdel-Daim, Mohamed M., Kilany, Omnia E., Karonen, Maarit, and Sinkkonen, Jari

Subjects
POLYPHENOLS, BAUHINIA, CARBON tetrachloride, NEPHROTOXICOLOGY, HEPATOTOXICOLOGY, LABORATORY mice, THERAPEUTICS
Abstract

The hepatoprotective and nephroprotective activity of a polyphenol-rich fraction (BHPF) obtained fromBauhinia hookeriwas investigated against CCl4-induced acute hepatorenal toxicity in mice. BHPF was administered (100, 200 and 400 mg/kg/day) for 5 days, then CCl4was administered. BHPF pretreatment significantly (p < 0.001) inhibited the CCl4-induced increase in ALT, AST, ALP, LDH, total bilirubin, cholesterol, creatinine, uric acid, urea and malondialdehyde in a dose-dependent manner. In contrast, BHPF pretreatment markedly increased the contents of glutathione and superoxide dismutase in the liver and kidney tissues, indicating the strongin vivoantioxidant activity of BHPF. Pretreatment with BHPF preserved the hepatic architecture and conferred marked protection against necrosis and ballooning degeneration. Pretreatment with BHPF reduced the inflammatory cell aggregation and degenerative changes in the lining epithelium of the kidney tubules. It can be concluded that BHPF has a remarkable hepato- and nephroprotective activity by enhancing the antioxidant defense status, reducing lipid peroxidation and protecting against the histopathological changes induced by CCl4in the liver and kidney tissues. [ABSTRACT FROM PUBLISHER]

Published
2015
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99. Preclinical Evaluation of Rapeseed, Raspberry, and Pine Bark Phenolics for Health Related Effects

Author

Vuorela, Satu, primary, Kreander, Kari, additional, Karonen, Maarit, additional, Nieminen, Riina, additional, Hämäläinen, Mari, additional, Galkin, Anna, additional, Laitinen, Leena, additional, Salminen, Juha-Pekka, additional, Moilanen, Eeva, additional, Pihlaja, Kalevi, additional, Vuorela, Heikki, additional, Vuorela, Pia, additional, and Heinonen, Marina, additional

Published
2005
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