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1,095 results on '"Kapczinski, Flavio"'

57. Association between solar insolation and a history of suicide attempts in bipolar I disorder

Author

Bauer, Michael, Glenn, Tasha, Alda, Martin, Andreassen, Ole A., Angelopoulos, Elias, Ardau, Raffaella, Ayhan, Yavuz, Baethge, Christopher, Bauer, Rita, Baune, Bernhard T., Becerra-Palars, Claudia, Bellivier, Frank, Belmaker, Robert H., Berk, Michael, Bersudsky, Yuly, Bicakci, Şule, Birabwa-Oketcho, Harriet, Bjella, Thomas D., Cabrera, Jorge, Wo Cheung, Eric Y., Del Zompo, Maria, Dodd, Seetal, Donix, Markus, Etain, Bruno, Fagiolini, Andrea, Fountoulakis, Kostas N., Frye, Mark A., Gonzalez-Pinto, Ana, Gottlieb, John F., Grof, Paul, Harima, Hirohiko, Henry, Chantal, Isometsä, Erkki T., Janno, Sven, Kapczinski, Flávio, Kardell, Mathias, Khaldi, Slim, Kliwicki, Sebastian, König, Barbara, Kot, Timur L., Krogh, Rikke, Kunz, Mauricio, Lafer, Beny, Landén, Mikael, Larsen, Erik R., Lewitzka, Ute, Licht, Rasmus W., Lopez-Jaramillo, Carlos, MacQueen, Glenda, Manchia, Mirko, Marsh, Wendy, Martinez-Cengotitabengoa, Mónica, Melle, Ingrid, Meza-Urzúa, Fátima, Ming, Mok Yee, Monteith, Scott, Morken, Gunnar, Mosca, Enrica, Mozzhegorov, Anton A., Munoz, Rodrigo, Mythri, Starlin V., Nacef, Fethi, Nadella, Ravi K., Nery, Fabiano G., Nielsen, René E., O'Donovan, Claire, Omrani, Adel, Osher, Yamima, Sørensen, Helle Østermark, Ouali, Uta, Ruiz, Yolanda Pica, Pilhatsch, Maximilian, Pinna, Marco, da Ponte, Francisco D.R., Quiroz, Danilo, Ramesar, Raj, Rasgon, Natalie, Reddy, M.S., Reif, Andreas, Ritter, Philipp, Rybakowski, Janusz K., Sagduyu, Kemal, Raghuraman, Bharathram Sathur, Scippa, Ângela M., Severus, Emanuel, Simhandl, Christian, Stackhouse, Paul W., Jr., Stein, Dan J., Strejilevich, Sergio, Subramaniam, Mythily, Sulaiman, Ahmad Hatim, Suominen, Kirsi, Tagata, Hiromi, Tatebayashi, Yoshitaka, Tondo, Leonardo, Torrent, Carla, Vaaler, Arne E., Vares, Edgar, Veeh, Julia, Vieta, Eduard, Viswanath, Biju, Yoldi-Negrete, Maria, Zetin, Mark, Zgueb, Yosra, and Whybrow, Peter C.

Published
2019
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68. Age-related deficits in intracortical myelination in young adults with bipolar disorder type I

Author

Sehmbi, Manpreet, Rowley, Christopher D., Minuzzi, Luciano, Kapczinski, Flavio, Kwiecien, Jacek M., Bock, Nicholas A., and Frey, Benicio N.

Subjects
Medical research, Bipolar disorder -- Research, Myelination -- Research, Young adults -- Health aspects, Youth, Health, Psychology and mental health
Abstract

Background: Previous studies have implicated white-matter-related changes in the pathophysiology of bipolar disorder. However, most of what is known is derived from in vivo subcortical white-matter imaging or postmortem studies. In this study, we investigated wholebrain intracortical myelin (ICM) content in people with bipolar disorder type I and controls. Methods: Between Sept. 1, 2014, and Jan. 31, 2017, we used a 3 T General Electric scanner to collect [T.sub.1]-weighted images in 45 people with bipolar disorder type I and 60 controls aged 17 to 45 years using an optimized sequence that was sensitive to ICM content. We analyzed images using a surface-based approach. We used general linear models with quadratic age terms to examine the signal trajectory of ICM across the age range. Results: In healthy controls, the [T.sub.1 -weighted signal followed an inverted-U trajectory over age; in people with bipolar disorder type I, the association between ICM and age followed a flat trajectory (p < 0.05, Bonferroni corrected). Exploratory analyses showed that ICM signal intensity was associated with duration of illness, age of onset, and anticonvulsant and antipsychotic use in people with bipolar disorder type I (p < 0.05, uncorrected). Limitations: Because of the cross-sectional nature of the study, we were unable to comment on whether the effects were due to dysmyelination or demyelination in bipolar disorder. Conclusion: This foundational study is, to our knowledge, the first to show global age-related deficits in ICM maturation throughout the cortex in bipolar disorder. Considering the i mpact of myelination on the maintenance of neural synchrony and the integrity of neural connections, this work may help us better understand the cognitive and behavioural deficits seen in bipolar disorder., Introduction White-matter abnormalities are among the most consistently replicated neurobiological findings in people with bipolar disorder. Neuroimaging studies focusing on subcortical tracts have linked white-matter abnormalities with a greater number [...]

Published
2019
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70. Lifestyle changes during the COVID-19 pandemic in Brazil: results from three consecutive cross-sectional web surveys

Author

Ribeiro-Alves, Marcelo, primary, Lucieri Costa, Giovanna, additional, Corrêa da Mota, Jurema, additional, de Azevedo Cardoso, Taiane, additional, Cerezer, Keila, additional, Martini, Thais, additional, Soriano de Sousa, Marina Ururahy, additional, Bastos, Francisco I, additional, Balanzá-Martínez, Vicent, additional, Kapczinski, Flavio, additional, and De Boni, Raquel Brandini, additional

Published
2023
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84. Resting-state functional connectivity in individuals with bipolar disorder during clinical remission: a systematic review

Author

Syan, Sabrina K., Smith, Mara, Frey, Benicio N., Remtulla, Raheem, Kapczinski, Flavio, Hall, Geoffrey B.C., and Minuzzi, Luciano

Subjects
Regression (Disease) -- Physiological aspects, Neurophysiology -- Comparative analysis -- Research, Neurological research, Bipolar disorder -- Research -- Comparative analysis -- Physiological aspects, Health, Psychology and mental health
Abstract

Background: Bipolar disorder is chronic and debilitating. Studies investigating resting-state functional connectivity in individuals with bipolar disorder may help to inform neurobiological models of illness. Methods: We conducted a systematic review with the following goals: to summarize the literature on resting-state functional connectivity in bipolar disorder during clinical remission (euthymia) compared with healthy controls; to critically appraise the literature and research gaps; and to propose directions for future research. We searched PubMed/MEDLINE, Embase, PsycINFO, CINAHL and grey literature up to April 2017. Results: Twenty-three studies were included. The most consistent finding was the absence of differences in resting-state functional connectivity of the default mode network (DMN), fronto-parietal network (FPN) and salience network (SN) between people with bipolar disorder and controls, using independent component analysis. However, 2 studies in people with bipolar disorder who were positive for psychosis history reported DMN hypoconnectivity. Studies using seed-based analysis largely reported aberrant resting-state functional connectivity with the amygdala, ventrolateral prefrontal cortex, cingulate cortex and medial prefrontal cortex in people with bipolar disorder compared with controls. Few studies used regional homogeneity or amplitude of low-frequency fluctuations. Limitations: We found heterogeneity in the analysis methods used. Conclusion: Stability of the DMN, FPN and SN may reflect a state of remission. Further, DMN hypoconnectivity may reflect a positive history of psychosis in patients with bipolar disorder compared with controls, highlighting a potentially different neural phenotype of psychosis in people with bipolar disorder. Resting-state functional connectivity changes between the amygdala, prefrontal cortex and cingulate cortex may reflect a neural correlate of subthreshold symptoms experienced in bipolar disorder euthymia, the trait-based pathophysiology of bipolar disorder and/or a compensatory mechanism to maintain a state of euthymia., Introduction Bipolar disorder is a major mental illness characterized by discrete periods of depression and mania (bipolar disorder type I) or hypomania (bipolar disorder type II), including changes in sleep, [...]

Published
2018
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94. Arketamine for bipolar depression: Open-label, dose-escalation, pilot study

Author

Bandeira, Igor D., Leal, Gustavo C., Correia-Melo, Fernanda S., Souza-Marques, Breno, Silva, Samantha S., Lins-Silva, Daniel H., Mello, Rodrigo P., Vieira, Flávia, Dorea-Bandeira, Ingrid, Faria-Guimarães, Daniela, Carneiro, Beatriz, Caliman-Fontes, Ana Teresa, Kapczinski, Flávio, Miranda-Scippa, Ângela, Lacerda, Acioly L.T., and Quarantini, Lucas C.

Published
2023
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