51. Sleep duration and the risk of future lipid profile abnormalities in middle-aged men: the Kansai Healthcare Study.
- Author
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Kinuhata S, Hayashi T, Sato KK, Uehara S, Oue K, Endo G, Kambe H, and Fukuda K
- Subjects
- Adult, Cholesterol blood, Dyslipidemias epidemiology, Humans, Hypertriglyceridemia epidemiology, Hypertriglyceridemia etiology, Japan epidemiology, Lipoproteins, HDL blood, Male, Middle Aged, Prospective Studies, Risk Factors, Sleep Deprivation complications, Sleep Deprivation epidemiology, Triglycerides blood, Dyslipidemias etiology, Sleep physiology
- Abstract
Background: Although short sleep duration has been reported to be associated with future cardiometabolic diseases, it is not fully understood whether sleep duration is prospectively associated with the risk of each lipid profile abnormality., Methods: Subjects were nondiabetic Japanese, 40-55 years of age, who were not taking oral lipid-lowering medications: for the incidence of low high-density lipoprotein cholesterol (HDL-C), 7627 men with an HDL-C level ≥ 40 mg/dL; for high triglycerides, 6973 men with a triglyceride level <200 mg/dL; for high low-density lipoprotein cholesterol (LDL-C), 7273 men with an LDL-C level <160 mg/dL; for high non-HDL-C, 7415 men with a non-HDL-C level <190 mg/dL; and for high total cholesterol (TC), 7196 men with a TC level <240 mg/dL. Lipid profile abnormalities were defined according to the Adult Treatment Panel III guidelines of the National Cholesterol Education Program., Results: During the 6-year observation period, there were 1022 cases of low HDL-C. Multiple-adjusted hazard ratios for low HDL-C were 0.79 (95% confidence interval, 0.64-0.97) for sleep durations of 5 to <7 h and 0.62 (0.46-0.83) for ≥ 7 h compared with <5 h. There were 1473 cases of high triglycerides. Multiple-adjusted hazard ratios for high triglycerides were 0.81 (0.68-0.98) for sleep durations of 5 to <7 h and 0.90 (0.72-1.13) for ≥ 7 h compared with <5 h. However, no association between sleep duration and the risk of future high LDL-C, non-HDL-C, or TC was observed., Conclusions: Moderate and/or long sleep durations decreased the risk of future low HDL-C and high triglycerides., (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Published
- 2014
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