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51. Genetic Control of Human Brain Transcript Expression in Alzheimer Disease

Author

Webster, Jennifer A., primary, Gibbs, J. Raphael, additional, Clarke, Jennifer, additional, Ray, Monika, additional, Zhang, Weixiong, additional, Holmans, Peter, additional, Rohrer, Kristen, additional, Zhao, Alice, additional, Marlowe, Lauren, additional, Kaleem, Mona, additional, McCorquodale, Donald S., additional, Cuello, Cindy, additional, Leung, Doris, additional, Bryden, Leslie, additional, Nath, Priti, additional, Zismann, Victoria L., additional, Joshipura, Keta, additional, Huentelman, Matthew J., additional, Hu-Lince, Diane, additional, Coon, Keith D., additional, Craig, David W., additional, Pearson, John V., additional, Heward, Christopher B., additional, Reiman, Eric M., additional, Stephan, Dietrich, additional, Hardy, John, additional, and Myers, Amanda J., additional

Published
2009
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52. A survey of genetic human cortical gene expression

Author

Myers, Amanda J, primary, Gibbs, J Raphael, additional, Webster, Jennifer A, additional, Rohrer, Kristen, additional, Zhao, Alice, additional, Marlowe, Lauren, additional, Kaleem, Mona, additional, Leung, Doris, additional, Bryden, Leslie, additional, Nath, Priti, additional, Zismann, Victoria L, additional, Joshipura, Keta, additional, Huentelman, Matthew J, additional, Hu-Lince, Diane, additional, Coon, Keith D, additional, Craig, David W, additional, Pearson, John V, additional, Holmans, Peter, additional, Heward, Christopher B, additional, Reiman, Eric M, additional, Stephan, Dietrich, additional, and Hardy, John, additional

Published
2007
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53. Sorl1 as an Alzheimer’s Disease Predisposition Gene?

Author

Webster, Jennifer A., primary, Myers, Amanda J., additional, Pearson, John V., additional, Craig, David W., additional, Hu-Lince, Diane, additional, Coon, Keith D., additional, Zismann, Victoria L., additional, Beach, Thomas, additional, Leung, Doris, additional, Bryden, Leslie, additional, Halperin, Rebecca F., additional, Marlowe, Lauren, additional, Kaleem, Mona, additional, Huentelman, Matthew J., additional, Joshipura, Keta, additional, Walker, Douglas, additional, Heward, Christopher B., additional, Ravid, Rivka, additional, Rogers, Joseph, additional, Papassotiropoulos, Andreas, additional, Hardy, John, additional, Reiman, Eric M., additional, and Stephan, Dietrich A., additional

Published
2007
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54. GAB2 Alleles Modify Alzheimer's Risk in APOE ɛ4 Carriers

Author

Reiman, Eric M., primary, Webster, Jennifer A., additional, Myers, Amanda J., additional, Hardy, John, additional, Dunckley, Travis, additional, Zismann, Victoria L., additional, Joshipura, Keta D., additional, Pearson, John V., additional, Hu-Lince, Diane, additional, Huentelman, Matthew J., additional, Craig, David W., additional, Coon, Keith D., additional, Liang, Winnie S., additional, Herbert, RiLee H., additional, Beach, Thomas, additional, Rohrer, Kristen C., additional, Zhao, Alice S., additional, Leung, Doris, additional, Bryden, Leslie, additional, Marlowe, Lauren, additional, Kaleem, Mona, additional, Mastroeni, Diego, additional, Grover, Andrew, additional, Heward, Christopher B., additional, Ravid, Rivka, additional, Rogers, Joseph, additional, Hutton, Michael L., additional, Melquist, Stacey, additional, Petersen, Ron C., additional, Alexander, Gene E., additional, Caselli, Richard J., additional, Kukull, Walter, additional, Papassotiropoulos, Andreas, additional, and Stephan, Dietrich A., additional

Published
2007
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55. A High-Density Whole-Genome Association Study Reveals That APOE Is the Major Susceptibility Gene for Sporadic Late-Onset Alzheimer's Disease

Author

Coon, Keith D., primary, Myers, Amanda J., additional, Craig, David W., additional, Webster, Jennifer A., additional, Pearson, John V., additional, Lince, Diane Hu, additional, Zismann, Victoria L., additional, Beach, Thomas G., additional, Leung, Doris, additional, Bryden, Leslie, additional, Halperin, Rebecca F., additional, Marlowe, Lauren, additional, Kaleem, Mona, additional, Walker, Douglas G., additional, Ravid, Rivka, additional, Heward, Christopher B., additional, Rogers, Joseph, additional, Papassotiropoulos, Andreas, additional, Reiman, Eric M., additional, Hardy, John, additional, and Stephan, Dietrich A., additional

Published
2007
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56. The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts

Author

Myers, Amanda J., primary, Pittman, Alan M., additional, Zhao, Alice S., additional, Rohrer, Kristen, additional, Kaleem, Mona, additional, Marlowe, Lauren, additional, Lees, Andrew, additional, Leung, Doris, additional, McKeith, Ian G., additional, Perry, Robert H., additional, Morris, Chris M., additional, Trojanowski, John Q., additional, Clark, Christopher, additional, Karlawish, Jason, additional, Arnold, Steve, additional, Forman, Mark S., additional, Van Deerlin, Vivianna, additional, de Silva, Rohan, additional, and Hardy, John, additional

Published
2007
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57. O2-02-02

Author

Myers, Amanda J., primary, Pittman, Alan M., additional, Rohrer, Kristen, additional, Zhao, Alice, additional, Leung, Doris, additional, Bryden, Leslie, additional, Kaleem, Mona, additional, Marlowe, Lauren, additional, Chung Fung, Hon, additional, Lees, Andrew, additional, Morris, Chris M., additional, de Silva, Rohan, additional, and Hardy, John A., additional

Published
2006
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58. Ubiquilin 1 polymorphisms are not associated with late‐onset Alzheimer's disease

Author

Smemo, Scott, primary, Nowotny, Petra, additional, Hinrichs, Anthony L., additional, Kauwe, John S. K., additional, Cherny, Sara, additional, Erickson, Katherine, additional, Myers, Amanda J., additional, Kaleem, Mona, additional, Marlowe, Lauren, additional, Gibson, Alison M., additional, Hollingworth, Paul, additional, O'Donovan, Michael C., additional, Morris, Chris M., additional, Holmans, Peter, additional, Lovestone, Simon, additional, Morris, John C., additional, Thal, Leon, additional, Li, Yonghong, additional, Grupe, Andrew, additional, Hardy, John, additional, Owen, Michael J., additional, Williams, Julie, additional, and Goate, Alison, additional

Published
2005
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63. Sorl1 as an Alzheimer’s Disease Predisposition Gene?

Author

Webster, Jennifer A., Myers, Amanda J., Pearson, John V., Craig, David W., Hu-Lince, Diane, Coon, Keith D., Zismann, Victoria L., Beach, Thomas, Leung, Doris, Bryden, Leslie, Halperin, Rebecca F., Marlowe, Lauren, Kaleem, Mona, Huentelman, Matthew J., Joshipura, Keta, Walker, Douglas, Heward, Christopher B., Ravid, Rivka, Rogers, Joseph, and Papassotiropoulos, Andreas

Subjects
ALZHEIMER'S disease, MUTATIONS (Algebra), HUMAN behavior, GENETICS, GENOMES, COGNITION, MEMORY, ADRENERGIC receptors
Abstract

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressively disabling impairments in memory, cognition, and non-cognitive behavioural symptoms. Sporadic AD is multifactorial and genetically complex. While several monogenic mutations cause early-onset AD and gene alleles have been suggested as AD susceptibility factors, the only extensively validated susceptibility gene for late-onset AD is the apolipoprotein E (APOE) ε4 allele. Alleles of the APOE gene do not account for all of the genetic load calculated to be responsible for AD predisposition. Recently, polymorphisms across the neuronal sortilin-related receptor (SORL1) gene were shown to be significantly associated with AD in several cohorts. Here we present the results of our large case-control whole-genome scan at over 500,000 polymorphisms which presents weak evidence for association and potentially narrows the association interval. [ABSTRACT FROM AUTHOR]

Published
2008
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64. Ubiquilin 1 polymorphisms are not associated with late‐onset Alzheimer's disease

Author

Smemo, Scott, Nowotny, Petra, Hinrichs, Anthony L., Kauwe, John S. K., Cherny, Sara, Erickson, Katherine, Myers, Amanda J., Kaleem, Mona, Marlowe, Lauren, Gibson, Alison M., Hollingworth, Paul, O'Donovan, Michael C., Morris, Chris M., Holmans, Peter, Lovestone, Simon, Morris, John C., Thal, Leon, Li, Yonghong, Grupe, Andrew, Hardy, John, Owen, Michael J., Williams, Julie, and Goate, Alison

Abstract

Several studies have reported evidence for linkage of late‐onset Alzheimer's disease (LOAD) to chromosome 9. Recently, an intronic polymorphism affecting alternative splicing of exon 8 of ubiquilin 1 (UBQLN1) was reported to be associated with LOAD. We attempted to replicate this observation by genotyping this polymorphism, rs12344615 (also known as UBQ‐8i), in a large sample of 1,544 LOAD cases and 1,642 nondemented controls. We did not find any evidence that this single nucleotide polymorphism, or any of six others tested in UBQLN1, increases risk for LOAD. Ann Neurol 2005

Published
2006
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67. Characterizing industry payments to ophthalmologists before and after onset of the COVID-19 pandemic.

Author

Choudhry HS, Choudhry HS, Burton C, Patel AM, Patel R, Li X, Berkowitz S, and Kaleem MA

Abstract

Purpose: The COVID-19 pandemic had profound effects on many different aspects of our healthcare system and the relationship between industry and physicians was no exception. The present database study evaluates industry payments to ophthalmologists in order to identify whether there are significant differences in industry payments to ophthalmologists before and after onset of the pandemic., Methods: The Centers for Medicare & Medicaid Services Open Payments Database was queried for all ophthalmologists who received industry payments between 2018 and 2021. Pre-Covid was defined as 2018-2019 while post-Covid was defined as 2020-2021. Payment date, value, type, company making payment, and state of recipient were recorded. The top ten companies and states in terms of payment value were included in analysis. Generalized Estimating Equations (GEE) modeling was used to assess significance., Results: There were 729,263 industry payments to 20,832 ophthalmologists totaling $817,892,867.54 included for analysis in this study. We found that there was a significant increase in the mean value of research payments and a significant decrease in the mean value of general payments after the onset of the pandemic (both p < 0.001). We also report significant changes in industry payments to ophthalmologists based on the company making the payment and the state in which the ophthalmologist practices., Conclusions: Our results suggest that significant differences exist in industry payment patterns to ophthalmologists following onset of the COVID-19 pandemic. Understanding underlying reasons for the observed differences may improve our understanding of the relationship between industry and clinical ophthalmology., Competing Interests: Conflicts of Interests: No conflicts of interest to report.

Published
2023
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68. Postoperative complications of Ab-Interno XEN implantation in primary angle closure glaucoma.

Author

Asanad S, Kalarn S, and Kaleem MA

Abstract

The XEN Gel Stent offers a unique Ab-interno approach for managing glaucoma and has shown a favorable risk profile relative to traditional trabeculectomy. XEN implantation has almost exclusively been reported in patients with open angle glaucoma and data in patients with angle closure glaucoma is limited. We report a postoperative complication of the XEN Gel Stent in a patient with primary angle closure glaucoma. An 86-year-old man with primary angle closure glaucoma underwent combined phacoemulsification and XEN implantation. After approximately two months, intraocular pressure was elevated and the stent was occluded by iris pigmentary deposits, traversing from the proximal to the distal conjunctival ends of the stent. Using an Ab-interno approach, the implant was successfully explanted, and the patient's intraocular pressure was notably lowered., Competing Interests: None., (AJCEI Copyright © 2021.)

Published
2021

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