74 results on '"Kalbande, P."'
Search Results
52. Two-wheeler tyre pressure monitoring through K-nearest neighbours algorithm trained using wheel hub vibrations acquired using ADXL335 accelerometer
- Author
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Jatakar, Keshav H., Mulgund, Gopal V., Patange, Abhishek D., Deshmukh, Bhagyesh B., Rambhad, Kishor S., and Kalbande, Vednath P.
- Abstract
Maintaining optimal tyre pressure enhances the performance of a vehicle in many ways. Tyre pressure monitoring system (TPMS) provides a safety feature that shows an alert when the car's tyre pressure drops below the recommended levels. In this paper, the TPMS is built through training of the KNN algorithm based on wheel hub vibrations. An inexpensive system was developed by interfacing the ADXL335 accelerometer with Arduino for collecting real-time data. In order to process the raw data suitable conditioning was undertaken. The initial judgment of wkNNheel hub vibrations was carried out statistically. The features reflecting the relevant statistical judgment of tyre pressure conditions were selected and training of the KNN algorithm was initiated. Perfectly filled, partially filled and unhealthy tyre conditions were considered while acquiring the wheel hub vibrations and classification was achieved.
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- 2022
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53. Hybrid nano-fluid for solar collector based thermal energy storage and heat transmission systems: A review
- Author
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Kalbande, Vednath P., Choudhari, Manoj S., and Nandanwar, Yogesh N.
- Abstract
Solar-based thermal energy storage (TES) systems, often integrated with solar collectors like parabolic troughs and flat plate collectors, play a crucial role in sustainable energy solutions. This article explores the use of hybrid nanofluids as a working fluid in thermal storage units, focusing on their potential to increase system efficiency. The review highlights the popularity of hybrid nanofluids, composed of oil and nanoparticles, as effective heat transfer fluids in solar energy-based thermal energy storage and heat transmission systems. Key findings highlight the superior heat transfer capabilities of multi-walled carbon nanotubes (MWCNT) and alumina nanoparticles when dispersed in various base fluids. Additionally, PCMs such as erythritol and nitrate salt emerge as optimal choices for efficiently storing thermal energy. The stored energy becomes invaluable during non-sunlight hours, offering a continuous and reliable energy supply. This study highlights the potential of hybrid nanoparticles as heat transfer fluids for solar-based thermal energy storage systems, opening the path for progress in sustainable and efficient energy use. Future directions may include further optimization of hybrid nanofluids, the incorporation of improved PCMs, and novel techniques to improve the overall efficiency of solar energy storage systems.
- Published
- 2024
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54. An artificial intelligence approach for the recognition of early stages of eczema
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Kalbande, Dhananjay, Naik, Rohit, Jatakia, Janvi, and Khopkar, Uday
- Abstract
The rural population of India suffers from various medical ailments and due to the lack of medical facilities and practitioners, enough support is not available. Medical help might come late and the problem might have been aggravated. With the increasing awareness about artificial intelligence (AI), it is possible to solve these problems using technology. The research aims at detecting an early stage of the skin disease 'eczema', when the affected part of the human body is captured through a smart phone and approximate symptoms are provided by the medical practitioner. It uses artificial intelligence algorithms like convolutional neural networks and support vector machines algorithm for classifying the images, and back propagation algorithm for training a model based on the symptoms. Around 50 clinical photographs of eczema acquired from KEM Hospital, Mumbai to train the classifier and then different images of eczema were tested with an accuracy of greater than 85%.
- Published
- 2020
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55. Security of 6LoWPAN IoT Networks in Hospitals for Medical Data Exchange.
- Author
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Yeole, Anjali, Kalbande, D.R., and Sharma, Avinash
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COMPUTER performance ,HOSPITALS ,DATA integrity - Abstract
It is well known that available approaches to IoT networks eschew certain security issues that may expose sensitive data to unauthorized entities. This paper proposes a security protocol for the IoT based communication. This protocol comprises of three levels of security checks namely authentication, confidentiality and integrity. Such algorithms do require large storage capacity and processing powers. However, nodes in IoT network have limited storage capacity and processing power. Proposed algorithm overcome this problem by reducing the number computations performed without losing the accuracy of data. Trust, Security and Privacy is established over a 6LoWPAN network running on RPL by keeping the CPU power consumption and storage requirements under check. The implementation of the proposed security scheme has been demonstrated for IoT based hospital networks in simulation with Cooja Network Simulator on Contiki OS [ABSTRACT FROM AUTHOR]
- Published
- 2019
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56. Real-time PCR assay for rapid, efficient and accurate detection of Paramyrothecium roriduma leaf spot pathogen of Gossypiumspecies
- Author
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Chavhan, R., Hinge, V., Kadam, U., Kalbande, B., and Chakrabarty, P.
- Abstract
Here we report a highly sensitive real-time PCR (qPCR) assay to detect Paramyrothecium roridumfrom pure culture and infected samples of cotton plants. A specific set of primer pair pMyro F/R is designed to target the 185 bp ITS region of rDNA of Paramyrothecium roridumspecies and validated using qPCR. The fluorescence signals were detected above the baseline threshold from samples containing Paramyrothecium roridumDNA, whereas other samples did not produce any fluorescence or produced fluorescence which did not reach detection threshold values. A single dissociation peak of increased fluorescence was obtained for the specific primers at 92.2 °C melting temperature. The limit of detection using SYBR Green dye in this assay was up to 0.1 pg per µL of DNA from pure culture of P. roridum. The assay is accurate, sensitive, less laborious and time saving for detection of P. roridumin infected tissues of cotton.
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- 2018
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57. Investigation on improved solar dryers for agriculture
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Kalbande, S.R., Khambalkar, V.P., and Deshmukh, Sneha
- Abstract
Due to high cost of fossil fuels and uncertainty regarding future cost and availability, use of sun drying of various agriculture products, vegetables, fruits, fish, milk products, food products, etc. is being practiced largely since ancient times for preservation of agriculture products. Despite many disadvantages of natural drying, almost 80% of farmers are using open sun drying method for drying their crops. Open sun drying, in which the product is spread on ground in open, is the simplest and cheapest method of drying. But there are considerable losses associated with it. So, the advanced method of drying i.e., solar drying can also be used for drying the products and improve the quality. In this paper, comprehensive study of solar drying of various products is presented.
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- 2018
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58. Multiplex molecular marker-assisted analysis of significant pathogens of cotton (Gossypium sp.).
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Chavhan, R.L., Sable, S., Narwade, A.V., Hinge, V.R., Kalbande, B.B., Mukherjee, A.K., Chakrabarty, P.K., and Kadam, Ulhas S.
- Subjects
PHYTOPATHOGENIC microorganisms ,COTTON ,GENETIC markers ,CROP yields ,PATHOGENIC microorganisms ,PLANT cells & tissues - Abstract
Plant pathogens diminish crop quality and yield, leading to economic losses. Molecular markers have the potential for early and accurate detection of pathogens. DNA markers based on ITS regions, pthN gene, and CP gene were designed to detect strains of fungal, bacterial, and viral pathogens, respectively. The pRS and pRB primers were found specific to strains of R. solani and R. bataticola. Four strains of R. areola isolates from each cultivated cotton species were detected using the primer pRARE. Further, CAPS markers, Bst 6I, and Dra RI specific to the strains of Alternaria macrospora were developed, which could differentiate from other fungal pathogens. Furthermore, we developed a multiplexed assay to detect six pathogens simultaneously. These diagnostic markers could help assess the prevalence of cotton infecting pathogens in the field (from plant tissue or soil). Consequently, the diagnostic assay could be used for undertaking judicious disease control measures in commercial agriculture. • Plant pathogens damage crop quality and yield; lead to economic losses. • Molecular markers have potential for early and accurate detection of various pathogens of cotton. • Mmarkers were designed to detect cotton's significant fungal, bacterial and viral pathogens. • Multiplexed analysis of various cotton pathogens is performed. [ABSTRACT FROM AUTHOR]
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- 2023
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59. Plant tissue culture independent Agrobacterium tumefaciens mediated In-planta transformation strategy for upland cotton (Gossypium hirsutum).
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Kalbande, Bipinchandra B. and Patil, Anita S.
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PLANT tissue culture ,AGROBACTERIUM tumefaciens ,COTTON ,TRANSGENIC plants ,BIOMEDICAL adhesives - Abstract
A new method of transgenic development called “ In-planta ” transformation method, where Agrobacterium is used to infect the plantlets but the steps of in vitro regeneration of plants is totally avoided. In this study, we have reported a simple In-planta method for efficient transformation of diploid cotton Gossypium hirsutum cv LRK-516 Anjali using Agrobacterium tumefaciens EHA-105 harbouring recombinant binary vector plasmid pBinAR with Arabidopsis At-NPR1 gene. Four day old plantlets were used for transformation. A vertical cut was made at the junction of cotyledonary leaves, moderately bisecting the shoot tip and exposing meristem cells at apical meristem. This site was infected with Agrobacterium inoculum. The transgenic events obtained were tested positive for the presence of At-NPR1 gene with promoter nptII gene. They are also tested negative for vector backbone integration and Agrobacterium contamination in T0 events. With this method a transformation frequency of 6.89% was reported for the cv LRK-516. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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60. Performance improvement of vapour compression refrigeration system using phase change material and thermoelectric generator
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Nandanwar, Yogesh N., Walke, Pramod V., Kalbande, Vednath P., and Mohan, Man
- Abstract
•The COP of refrigeration system is improved by achieving sub-cooling of the refrigerant using phase change material.•Heat stored in phase change material is supplied to thermoelectric generator's hot end, and electric power is generated from the waste heat of refrigerant.•The net-work input is reduced as compared to a conventional system using a thermoelectric generator.•Around 7% improvement in the COP of refrigeration system is achieved.
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- 2023
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61. Enhanced Security for ATM Machine with OTP and Facial Recognition Features.
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Karovaliya, Mohsin, Karedia, Saifali, Oza, Sharad, and Kalbande, D.R.
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FACE perception ,VISUAL perception ,COMPUTER passwords ,COMPUTER security ,COMPUTER access control - Abstract
The purpose of this paper is to reinforce security of the conventional ATM model. We have posited a new concept that enhances the overall experience, usability and convenience of the transaction at the ATM. Features like face recognition and One-Time Password (OTP) are used for the enhancement of security of accounts and privacy of users. Face recognition technology helps the machine to identify each and every user uniquely thus making face as a key. This completely eliminates the chances of fraud due to theft and duplicity of the ATM cards. Moreover, the randomly generated OTP frees the user from remembering PINs as it itself acts as a PIN. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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62. Performance Evaluation of Novel Heat Pipe‐Assisted Thermal Storage System with Parabolic Trough Solar Collector Using Nanofluid
- Author
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Kalbande, Vednath P., Walke, Pramod V., Untawale, Sachin, and Mohan, Man
- Abstract
The experimentation has been performed in Central Indian climatic conditions to investigate the performance of the novel heat‐pipe‐assisted thermal storage system with parabolic trough solar collector and nanofluid. The present thermal energy storage system is nanofluid (Al2O3/soybean oil) based and the eutectic mixture of KNO3and NaNO3(nitrate salt) in the molar ratio of 40:60 has been used as phase change material to store the heat energy. The system is based on the natural circulation of heat transfer fluid (thermo‐syphon) and the receiver to arrest the solar radiation is parabolic trough solar collector using an evacuated tube. The major and novel incorporation in this system is the heat pipe insertion in the storage unit of the system, which provides better heat transfer, and hence the improved storage capacity is achieved. The final remark of this study has been done with the comparison of the present system with the existing and similar kinds of thermal energy storage systems. For the same charging cycle time and same climatic conditions, the compared value of specific heat storage capacity is 67% higher as compared to the average value of other considered systems. The heat pipe is more useful in the thermal storage system to store and transfer energy. The parabolic trough solar collector is best suitable for the solar‐based thermal storage system. The thermal storage can operate on solar energy and temperatures above 220 °C.
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- 2022
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63. A Unique Variation of Flexor Digitorum Superficialis Muscle and Its Clinical Significance
- Author
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Anita, Takkallapalli, Kalbande, Sanjay, Asha, Krishnamurthy, Dombe, Dattatray, and Jayasree, Neelee
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AbstractA wide array of supernumerary and accessory musculature of forearm has been described in the anatomical, surgical and radiological literature. In majority of the cases, these accessory muscles are asymptomatic but in some cases, these accessory muscles produce clinical symptoms. They may be present as a palpable soft swelling or as a fibro-osseous mass near carpal tunnel with symptoms of neurovascular compression. In symptomatic cases, recognition and careful evaluation of accessory muscle with electromyographic examination may aid in diagnosis and in finalizing the treatment. We report a rare case of accessory muscle bellies arising from Flexor Digitorum Superficialis (FDS) muscle on right and left sides. During routine dissections of the forearm performed by preclinical students in the department of anatomy, we observed an accessory muscle belly arising from the tendon of index finger of flexor digitorum superficialis muscle on the right and left sides of a cadaver. The accessory muscle belly has taken its origin at the junction of upper two third and lower one third of forearm and traversed in the carpal tunnel and merged with the tendon of FDS to the index finger in the hand at the level of origin of first lumbrical.Although many anatomical variations of FDS muscle were reported in the past, we describe a rare case, first of its kind, which to our knowledge has not been mentioned in the literature till date.
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- 2012
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64. Monitoring of Blood Pressure of Children of Hypertensive Parents in their Early Ages Reduces the Risk of Having Cardiovascular Diseases in Future: A Study Conducted on Adolescents
- Author
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Kalbande, Sanjay and Anitha, T
- Abstract
AbstractHypertension is a silent but known risk factor for cardiovascular diseases and is estimated to contribute 4.5 percent of current global disease burden in developed countries and many developing countries. A family history of cardiovascular disease has been shown to be a risk factor for the subsequent development of the disease in children. Hence, the present study was conducted keeping in mind the objective to measure the anthropometric parameters of young healthy adults and its association with presence or absence of parental history of hypertension. A cross-sectional study was conducted on 18-25 years collegegoing 200 adolescents of both sexes. Half of the students were selected having parental history of hypertension and half were selected without any history of parental hypertension. A pretested questionnaire was used along with anthropometric measurements to know obesity or overweight. Among the 200 participants, 63 percent were male with average age 20.12 years (SD ±2.01). 32 percent had Body Mass Index more than 25, their prevalence being 35.5 percent in male and 26.3 percent in female compared to that in offspring of normotensive parents which was 10 percent for both genders, 12.5 percent for male and 5.6 percent for female. Out of the 100 participants of the study group, 56 have their Waist Hip Ratio above the standard defined cut-off for their respective sex. There is a definite need of monitoring the children’s of parental history of hypertension with other non communicable diseases like diabetes & obesity to prevent the occurrence of disease in future.
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- 2012
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65. Total Productive Maintenance - Accelerating OEE in a Manufacturing Industry Leveraging Pervasive Technologies
- Author
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Kalbande, D. R. and Thampi, G. T.
- Abstract
Total productive maintenance (TPM) is a people-intensive, preventive maintenance system for maximizing equipment effectiveness in the enterprise. The concept of TPM was originally suggested by Nakajima (1988) who proposed overall equipment effectiveness (OEE) as a metric for evaluating the progress of TPM, which is interpreted as the multiplication of availability, performance and quality. This paper aims to study and investigate the implementation of a TPM to improve the OEE in manufacturing enterprises. In today’s industrial scenario huge losses occur in the manufacturing shop floor. These losses are due to operators, maintenance personal, process, tooling problems and non-availability of components in time etc. The quality related waste are of significant importance as they matter the company in terms of time, material and the hard earned reputation of the company. There are also other invisible losses like operating the machines below the rated speed, start up loss, break down of the machines and bottle necks in process. Zero oriented concepts such as zero tolerance for losses, defects, break down and zero accidents are becoming a pre-requisite in the manufacturing and assembly industry. In this situation, a TPM is the answer to resolve the above said problems which helps in benefitting the growth prospects of any organization.
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- 2011
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66. Experimental and theoretical study for suitability of hybrid nano enhanced phase change material for thermal energy storage applications
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Kalbande, Vednath P., Fating, Ganesh, Mohan, Man, Rambhad, Kishor, and Sinha, Agnivesh Kumar
- Abstract
The present experiment and analytical study was carried out for suitability analysis of novel hybrid system of nano-enhanced Phase change material (PCM) for thermal energy storage applications. In this study, an experimental setup of a hybrid thermal energy storage system was fabricated. Parabolic dish solar collector was used as receiver of solar energy so as to store heat via PCM. And experimentation was conducted with selected nano enhanced PCM after comparing the heat storage capacity of various available nano-enhance PCMs from past literature. Further, the detailed comparison was carried out between pure paraffin wax and it's composite with CuO-MWCNT on the basis of their attributes like thermal conductivity, heat capacity, and useful temperature range. Results showed that nano-enhanced PCM exhibited 6.125% higher thermal conductivity than that of pure paraffin wax. It was also observed from the experimentation that time taken by nano-enhanced PCM for complete transformation from solid to liquid phase was 66.6% lower than the time taken by pure paraffin wax. This study also unveils that the hybrid system exhibited wide range of useful temperature band that is from 60 °C–180 °C which confirms its suitability for efficient space heating applications.
- Published
- 2022
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67. Adaptive classification to reduce non-stationarity in visual evoked potential brain-computer interfaces
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Kapgate, Deepak, Kalbande, Dhananjay, and Shrawankar, Urmila
- Abstract
Non-stationarity of electroencephalogram (EEG) signals greatly affect classifier performance in brain-computer interface (BCI). To overcome this problem we propose an adaptive classifier model known as extended multi-class pooled mean linear discriminant analysis (EMPMLDA). Here, we update the average class pair co-variance matrix along with pooled mean values. Evaluation of classifiers are done on visual evoked cortical potential data-sets. We demonstrate that EMPMLDA can significantly outperform other static classifiers such as MLDA and adaptive classifiers (MPMLDA). Furthermore an optimal update coefficient can be achieved using different datasets.
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- 2019
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68. Lip reading using neural networks
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Kalbande, Dhananjay, Mishra, Akassh A, Patil, Sanjivani, Nirgudkar, Sneha, and Patel, Prashant
- Abstract
Computerized lip reading, or speech reading, is concerned with the difficult task of converting a video signal of a speaking person to written text. It has several applications like teaching deaf and dumb to speak and communicate effectively with the other people, its crime fighting potential and invariance to acoustic environment. We convert the video of the subject speaking vowels into images and then images are further selected manually for processing. However, several factors like fast speech, bad pronunciation, and poor illumination, movement of face, moustaches and beards make lip reading difficult. Contour tracking methods and Template matching are used for the extraction of lips from the face. K Nearest Neighbor algorithm is then used to classify the 'speaking' images and the 'silent' images. The sequence of images is then transformed into segments of utterances. Feature vector is calculated on each frame for all the segments and is stored in the database with properly labeled class. Character recognition is performed using modified KNN algorithm which assigns more weight to nearer neighbors. This paper reports the recognition of vowels using KNN algorithms
- Published
- 2011
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69. Energy conservation using face detection
- Author
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Deotale, Nilesh T., Kalbande, Dhananjay R., and Mishra, Akassh A.
- Abstract
Computerized Face Detection, is concerned with the difficult task of converting a video signal of a person to written text. It has several applications like face recognition, simultaneous multiple face processing, biometrics, security, video surveillance, human computer interface, image database management, digital cameras use face detection for autofocus, selecting regions of interest in photo slideshows that use a pan-and-scale and The Present Paper deals with energy conservation using face detection. Automating the process to a computer requires the use of various image processing techniques. There are various methods that can be used for Face Detection such as Contour tracking methods, Template matching, Controlled background, Model based, Motion based and color based. Basically, the video of the subject are converted into images are further selected manually for processing. However, several factors like poor illumination, movement of face, viewpoint-dependent Physical appearance, Acquisition geometry, Imaging conditions, Compression artifacts makes Face detection difficult. This paper reports an algorithm for conservation of energy using face detection for various devices. The present paper suggests Energy Conservation can be done by Detecting the Face and reducing the brightness of complete image and then adjusting the brightness of the particular area of an image where the face is located using histogram equalization.
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- 2011
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70. EVIDENCE OF CLAY ILLUVIATION IN SODIC SOILS OF THE INDOGANGETIC PLAIN SINCE THE HOLOCENE
- Author
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PAL, D. K., KALBANDE, A. R., DESHPANDE, S. B., and SEHGAL, J. L.
- Abstract
Many of the micaceous soils of the IndoGangetic alluvial plain of northwestern India are sodic and have clayenriched textural B horizons. These soils sometimes lack identifiable clay skins. In order to determine the genesis of the textural B horizons of these soils, both with and without identifiable clay skins, one Natrustalf Sakit soil and one Aeric Halaquept Rahamabad soil were selected for study.
- Published
- 1994
71. Evaluation of gross target volumes in CECT vs MRI in head and neck cancer and its implication on concordance indices and dose-volume parameters of IMRT treatment plan.
- Author
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Deshmukh M, Jain BM, Singh A, Kalbande P, Tayade A, and Datta NR
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- Humans, Male, Female, Middle Aged, Aged, Adult, Tumor Burden, Contrast Media, Head and Neck Neoplasms radiotherapy, Head and Neck Neoplasms diagnostic imaging, Head and Neck Neoplasms pathology, Magnetic Resonance Imaging methods, Radiotherapy Planning, Computer-Assisted methods, Radiotherapy, Intensity-Modulated methods, Radiotherapy Dosage, Tomography, X-Ray Computed methods
- Abstract
Background: Although radiotherapy treatment planning (RTP) for head and neck cancers (HNCs) is based on contrast enhanced computed tomography (CECT), soft tissue contrasts are better evident on magnetic resonance imaging (MRI). We therefore evaluated dose-volume histogram (DVH) parameters along with concordance index (ConI), conformity index (CI), and homogeneity index (HI) of planning target volume (PTV) of GTV delineated on CECT vs MRI in HNCs enrolled for intensity modulated radiotherapy (IMRT)., Methodology: Forty consecutive HNCs were enrolled in this study. All underwent CECT and MRI simulations with immobilization devices. GTVp and GTVn were delineated independently on CECT and MRI images. Corresponding MRI volumes were then copied to CECT. IMRT plans were generated on the CECT incorporating PTV margins. DVH parameters of PTVpn for both CECT and MRI were compared. In addition, mean (±SD) percentage difference of GTVp, GTVn, GTVpn, ConI, CI, and HI were evaluated using paired t-test., Results: The GTVp (P = 0.005), GTVn (P = 0.009), and GTVpn (P < 0.001) delineated on MRI were found to be significantly larger than GTV delineated on CECT. In eight patients, GTV outlined on CECT were larger than MRI. Significant mean differences in CECT vs MRI of CI (P < 0.001), HI (P < 0.001), ConI (P < 0.001), and DVH parameters (D2, D95, D98, V95, and V100 all P < 0.001; D50: P = 0.009) were noted., Conclusion: The GTVs and corresponding PTVs were significantly larger on MRI compared to CECT. This resulted in significant differences in DVH parameters, CI, ConI, and HI. This could be improved by co-registered MRI-CECT volumes during routine IMRT treatment planning for HNCs., (Copyright © 2024 Copyright: © 2024 Journal of Cancer Research and Therapeutics.)
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- 2024
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72. Disseminated granuloma annulare: a cutaneous sign of diabetes mellitus.
- Author
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Rachamadugu K, Madke B, Talasila SR, and Kalbande P
- Subjects
- Humans, Skin, Administration, Cutaneous, Granuloma Annulare diagnosis, Diabetes Mellitus
- Abstract
Competing Interests: Competing interests: None declared.
- Published
- 2024
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73. Carcinoma of the pyriform sinus with mediastinal metastasis successfully treated with chemoradiotherapy in resource-constraint setup.
- Author
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Kalbande P, Kale P, and Ardha A
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- Aged, Chemoradiotherapy methods, Combined Modality Therapy, Humans, Male, Carcinoma, Squamous Cell pathology, Pyriform Sinus pathology, Radiotherapy, Conformal, Radiotherapy, Intensity-Modulated
- Abstract
Squamous cell carcinoma (SCC) of the pyriform sinus with metastatic mediastinal mass is staged as IVC and routinely treated with palliative intent. Here, we report a case cured with radical chemoradiotherapy without CT simulator, lead cutouts, and advanced techniques such as three-dimensional conformal radiation therapy, intensity-modulated radiation therapy, image-guided radiotherapy, and volumetric modulated arc therapy or stereotactic body radiotherapy. A 67-year-old male presented with SCC of the right pyriform sinus with mediastinal metastasis (Stage IVC). He was started with palliative chemotherapy afferent, but he could not tolerate it. Further, he was treated with radical chemoradiotherapy to dose of 60/30# to primary + neck with 6 MV photons and 50 Gy/25# to the anterior mediastinal lesion using 18 Mev electrons. Complete response to the treatment was achieved. At the close follow-up of 58 months, the patient is disease-free and follow-up is still ongoing. Limited metastatic disease can be completely cured using multimodality treatment using simple traditional 2D techniques, though optimal dose escalation becomes a limitation. Some variants of SCC do respond well even at suboptimal radiotherapy doses, so personalized treatment can be considered in such patients., Competing Interests: None
- Published
- 2022
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74. Hyperthermia: A Potential Game-Changer in the Management of Cancers in Low-Middle-Income Group Countries.
- Author
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Datta NR, Jain BM, Mathi Z, Datta S, Johari S, Singh AR, Kalbande P, Kale P, Shivkumar V, and Bodis S
- Abstract
Loco-regional hyperthermia at 40-44 °C is a multifaceted therapeutic modality with the distinct triple advantage of being a potent radiosensitizer, a chemosensitizer and an immunomodulator. Risk difference estimates from pairwise meta-analysis have shown that the local tumour control could be improved by 22.3% ( p < 0.001), 22.1% ( p < 0.001) and 25.5% ( p < 0.001) in recurrent breast cancers, locally advanced cervix cancer (LACC) and locally advanced head and neck cancers, respectively by adding hyperthermia to radiotherapy over radiotherapy alone. Furthermore, thermochemoradiotherapy in LACC have shown to reduce the local failure rates by 10.1% ( p = 0.03) and decrease deaths by 5.6% (95% CI: 0.6-11.8%) over chemoradiotherapy alone. As around one-third of the cancer cases in low-middle-income group countries belong to breast, cervix and head and neck regions, hyperthermia could be a potential game-changer and expected to augment the clinical outcomes of these patients in conjunction with radiotherapy and/or chemotherapy. Further, hyperthermia could also be a cost-effective therapeutic modality as the capital costs for setting up a hyperthermia facility is relatively low. Thus, the positive outcomes evident from various phase III randomized trials and meta-analysis with thermoradiotherapy or thermochemoradiotherapy justifies the integration of hyperthermia in the therapeutic armamentarium of clinical management of cancer, especially in low-middle-income group countries.
- Published
- 2022
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