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573 results on '"Kadono, Yoshifumi"'

54. Usefulness of serum CCL2 as prognostic biomarker in prostate cancer: a long-term follow-up study

Author

Iwamoto, Hiroaki, primary, Izumi, Kouji, additional, Nakagawa, Ryunosuke, additional, Toriumi, Ren, additional, Aoyama, Shuhei, additional, Shimada, Takafumi, additional, Kano, Hiroshi, additional, Makino, Tomoyuki, additional, Kadomoto, Suguru, additional, Yaegashi, Hiroshi, additional, Kawaguchi, Shohei, additional, Nohara, Takahiro, additional, Shigehara, Kazuyoshi, additional, Kadono, Yoshifumi, additional, and Mizokami, Atsushi, additional

Published
2022
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56. Suppression of androgen receptor signaling induces prostate cancer migration via activation of the CCL20–CCR6 axis.

Author

Kano, Hiroshi, Izumi, Kouji, Hiratsuka, Kaoru, Toriumi, Ren, Nakagawa, Ryunosuke, Aoyama, Shuhei, Kamijima, Taiki, Shimada, Takafumi, Naito, Renato, Kadomoto, Suguru, Iwamoto, Hiroaki, Yaegashi, Hiroshi, Kawaguchi, Shohei, Nohara, Takahiro, Shigehara, Kazuyoshi, Kadono, Yoshifumi, Saito, Yohei, Nakagawa‐Goto, Kyoko, Yoshioka, Kazuaki, and Nakata, Hiroki

Abstract

The suppression of androgen receptor (AR) expression exacerbates the migration potential of prostate cancer. This study identified a previously unrecognized regulation of the AR‐controlled pathway that promotes migration potential in prostate cancer cells. Prostate cancer cells that pass through a transwell membrane (mig cells) have a higher migration potential with a decreased AR expression than parental cells. In this study, we aimed to elucidate the mechanism of migration enhancement associated with the suppression of AR signaling. Expression of C–C motif ligand 20 (CCL20) is upregulated in mig cells, unlike in the parental cells. Knockdown of AR with small interfering RNA (siAR) in LNCaP and C4‐2B cells increased CCL20 secretion and enhanced the migration of cancer cells. Mig cells, CCL20‐treated cells, and siAR cells promoted cell migration with an enhancement of AKT phosphorylation and Snail expression, while the addition of a C–C chemokine receptor 6 (CCR6, the specific receptor of CCL20) inhibitor, anti‐CCL20 antibody, and AKT inhibitor suppressed the activation of AKT and Snail. With 59 samples of prostate cancer tissue, CCL20 secretion was profuse in metastatic cases despite low AR expression levels. Snail expression was associated with the expression of CCL20 and CCR6. A xenograft study showed that the anti‐CCL20 antibody significantly inhibited Snail expression, thereby suggesting a new therapeutic approach for castration‐resistant prostate cancer with the inhibition of the axis between CCL20 and CCR6. [ABSTRACT FROM AUTHOR]

Published
2023
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62. Effects of Tadalafil 5 mg Once-Daily on Serum Testosterone Level, Erectile Function, and Highly Sensitive C-Reactive Protein Value in Hypogonadal Patients with Lower Urinary Tract Symptoms

Author

Shigehara, Kazuyoshi, Shimamura, Masayoshi, Kawaguchi, Shohei, Nohara, Takahiro, Izumi, Kouji, Kadono, Yoshifumi, Shouda, Ryouchu, and Mizokami, Atsushi

Subjects
Lower urinary tract symptoms, Testosterone, Creactive protein, 494.9, Benign prostatic hypertrophy, Tadalafil
Abstract

Five mg tadalafil was administered once-daily to 48 patients for 6 months. Their International Prostatic Symptoms Score (IPSS), Overactive Bladder Symptoms Score (OABSS), Sexual Health Inventory for Men (SHIM), post-voided residual (PVR) volume, free testosterone (FT) level, prostate-specific antigen level, and highly sensitive C-reactive protein (hsCRP) value obtained before and 6 months after the treatment were analyzed. The treatment significantly improved the IPSS, OABSS, SHIM score, and PVR volume (P

Published
2020

63. Enzalutamide versus abiraterone plus prednisolone before chemotherapy for Japanese castration-resistant prostate cancer patients: An investigator-initiated, multicenter, randomized controlled trial.

Author

Izumi, Kouji, primary, Shima, Takashi, additional, Mita, Koji, additional, Kato, Yuki, additional, Kamiyama, Manabu, additional, Inoue, Shogo, additional, Tanaka, Nobumichi, additional, Hoshi, Seiji, additional, Okamura, Takehiko, additional, Yoshio, Yuko, additional, Enokida, Hideki, additional, Chikazawa, Ippei, additional, Kawai, Noriyasu, additional, Hashimoto, Kohei, additional, Fukagai, Takashi, additional, Shigehara, Kazuyoshi, additional, Takahara, Shizuko, additional, Kadono, Yoshifumi, additional, and Mizokami, Atsushi, additional

Published
2022
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65. Analysis of the Safety of Pegfilgrastim Addition in Bleomycin, Etoposide, and Cisplatin Treatment Patients With Germ Cell Tumors

Author

Nakagawa, Ryunosuke, primary, Iwamoto, Hiroaki, additional, Makino, Tomoyuki, additional, Kadomoto, Suguru, additional, Yaegashi, Hiroshi, additional, Iijima, Masashi, additional, Kawaguchi, Shohei, additional, Nohara, Takahiro, additional, Shigehara, Kazuyoshi, additional, Izumi, Kouji, additional, Kadono, Yoshifumi, additional, and Mizokami, Atsushi, additional

Published
2022
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69. Are bladder washing samples suitable for investigation of HPV infection in urinary bladder? Comparison in HPV prevalence between urine and washing samples.

Author

Nakagawa, Tomomi, Shigehara, Kazuyoshi, Kato, Yuki, Kawaguchi, Shohei, Nakata, Hiroki, Nakano, Taito, Izumi, Kouji, Kadono, Yoshifumi, and Mizokami, Atsushi

Subjects
BLADDER, BLADDER cancer, PAPILLOMAVIRUSES, URINE, POLYMERASE chain reaction, IN situ hybridization
Abstract

Although urine and bladder washing samples are commonly used for the cytological evaluation of the bladder mucosa, it has been unknown whether these samples are likely suitable to investigate human papillomavirus (HPV) prevalence in the urinary bladder. The present study aimed to elucidate the appropriateness of spontaneously voided urine or bladder washing in screening HPV infection in the urinary bladder. Urine and bladder washing samples were obtained from 201 patients who underwent transurethral bladder tumor resection. After extracting DNA from both samples, HPV‐DNA was examined using a nested polymerase chain reaction with GP5+/6+ and MY09/11 primers. HPV genotyping was performed in the HPV‐positive samples. In situ hybridization (ISH) was performed to observe the HPV‐DNA localization in urothelial cells among cytological samples and paraffin‐embedded tumor tissues in HPV‐positive washing samples. HPV prevalence in urine and washing samples were 9.5% and 7.0%, respectively. High‐risk HPV prevalence in urine and washing samples was 7.5% and 4.0%, respectively. The most common HPV type was HPV 16, followed by HPV 52 and HPV 18 in both samples. HPV type distribution in both samples was not in agreement (κ = −0.431). The ISH analysis revealed that HPV‐DNA signal was observed in urothelial cells of five (55.7%) of nine detectable HPV‐positive cytological samples. Six (66.7%) of nine HPV‐positive cases had HPV‐DNA signals in tumor tissue. The use of washing samples was likely applicable for investigating HPV prevalence in the urinary bladder. HPV‐DNA detected in washing samples might be frequently derived from the urinary bladder. [ABSTRACT FROM AUTHOR]

Published
2023
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70. Decreased febrile neutropenia during inpatient chemotherapy for urologic cancer during coronavirus disease 2019 pandemic.

Author

Toriumi, Ren, Yaegashi, Hiroshi, Kadomoto, Suguru, Iwamoto, Hiroaki, Iijima, Masashi, Kawaguchi, Shohei, Nohara, Takahiro, Shigehara, Kazuyoshi, Izumi, Kouji, Kadono, Yoshifumi, and Mizokami, Atsushi

Abstract

Since 2020, the coronavirus disease 2019 pandemic has led to the widespread practice of hand hygiene and wearing face masks, not only among medical personnel, but also among the general population. Thus, the impact of the coronavirus disease 2019 pandemic on the incidence of febrile neutropenia should be verified. This study aimed to examine the incidence of febrile neutropenia in hospitalized patients receiving chemotherapy at Kanazawa University Hospital. Among inpatients at the Department of Urology receiving chemotherapy, we compared the incidence of febrile neutropenia between 317 cases in 2018–2019 and 276 cases in 2020. We retrospectively analyzed the factors of febrile neutropenia via binomial logistic regression analysis based on patient characteristics and the characteristics of primary diseases, with statistical significance set at p < 0.05. Febrile neutropenia occurred in 20/317 cases in 2018–2019 and 1/276 cases in 2020, with a significant decrease in the latter (p = 0.005). In a multivariate analysis, we identified the following independent risk factors for febrile neutropenia: non‐coronavirus disease 2019 era (p = 0.005), first course of therapy (p = 0.005), malnutrition (p = 0.032), and past history of febrile neutropenia (p = 0.018). Due to the coronavirus disease 2019 pandemic, hygiene policies for medical personnel and quarantine measures for patients were thoroughly implemented. Therefore, the incidence of febrile neutropenia in 2020 decreased to 1/15 of the previous incidence. Thus, the hygiene for medical personnel and patients during the expected period of chemotherapy‐induced neutropenia is important for febrile neutropenia prevention. [ABSTRACT FROM AUTHOR]

Published
2023
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78. Investigating The Mechanism Underlying Urinary Continence Using Dynamic-MRI After Retzius-sparing Robot-assisted Radical Prostatectomy

Author

Kadono, Yoshifumi, primary, Nohara, Takahiro, additional, Kawaguchi, Shohei, additional, Kadomoto, Suguru, additional, Iwamoto, Hiroaki, additional, Iijima, Masashi, additional, Shigehara, Kazuyoshi, additional, Izumi, Kouji, additional, Yoshida, Kotaro, additional, Gabata, Toshifumi, additional, and Mizokami, Atsushi, additional

Published
2021
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84. Androgen replacement therapy for cancer‐related symptoms in male: result of prospective randomized trial (ARTFORM study)

Author

Izumi, Kouji, primary, Iwamoto, Hiroaki, additional, Yaegashi, Hiroshi, additional, Nohara, Takahiro, additional, Shigehara, Kazuyoshi, additional, Kadono, Yoshifumi, additional, Nanjo, Shigeki, additional, Yamada, Tadaaki, additional, Ohtsubo, Koshiro, additional, Yano, Seiji, additional, and Mizokami, Atsushi, additional

Published
2021
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87. Blood Cell Count Biomarkers Predicting Efficacy of Pembrolizumab as Second-line Therapy for Advanced Urothelial Carcinoma

Author

KADONO, YOSHIFUMI, primary, KAWAGUCHI, SHOHEI, additional, NOHARA, TAKAHIRO, additional, SHIGEHARA, KAZUYOSHI, additional, IZUMI, KOUJI, additional, KAMIJIMA, TAIKI, additional, SETO, CHIKASHI, additional, TAKANO, AKINOBU, additional, YOTSUYANAGI, SATOSHI, additional, NAKAGAWA, RYUNOSUKE, additional, MIYAGI, TOHRU, additional, AOYAMA, SHUHEI, additional, ASAHI, HIDEKI, additional, FUKUDA, RIE, additional, and MIZOKAMI, ATSUSHI, additional

Published
2021
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88. This title is unavailable for guests, please login to see more information.

Author

Shigehara, Kazuyoshi, Shimamura, Masayoshi, Kawaguchi, Shohei, Nohara, Takahiro, Izumi, Kouji, Kadono, Yoshifumi, Shouda, Ryouchu, Mizokami, Atsushi, Shigehara, Kazuyoshi, Shimamura, Masayoshi, Kawaguchi, Shohei, Nohara, Takahiro, Izumi, Kouji, Kadono, Yoshifumi, Shouda, Ryouchu, and Mizokami, Atsushi

Abstract

Five mg tadalafil was administered once-daily to 48 patients for 6 months. Their International Prostatic Symptoms Score (IPSS), Overactive Bladder Symptoms Score (OABSS), Sexual Health Inventory for Men (SHIM), post-voided residual (PVR) volume, free testosterone (FT) level, prostate-specific antigen level, and highly sensitive C-reactive protein (hsCRP) value obtained before and 6 months after the treatment were analyzed. The treatment significantly improved the IPSS, OABSS, SHIM score, and PVR volume (P<0.05), and significantly increased the mean FT level from 6.68 to 7.10 pg/ml ; P<0.05. We observed no significant changes in the hsCRP value and PSA level. However, elevated FT values were noted in 25 (52.1%) patients 6 months after the treatment (FT-increased group). Compared with the non-FT-increased group, the FT-increased group had markedly lower baseline FT value and higher prostatic volume. In both groups, IPSS and OABSS improved considerably. Moreover, the PVR volume, SHIM score, and hsCRP value markedly improved in the FT-increased group (P<0.05). Thus, 5 mg tadalafil administered oncedaily improved IPSS, OABSS, and erectile function, and increased the FT value, in hypogonadal patients with lower urinary tract symptoms. Furthermore, the hsCRP value declined considerably in patients with posttreatment elevated FT level.

Published
2020

90. A new flavonoid derivative exerts antitumor effects against androgen‐sensitive to cabazitaxel‐resistant prostate cancer cells

Author

Naito, Renato, primary, Kano, Hiroshi, additional, Shimada, Takashi, additional, Makino, Tomoyuki, additional, Kadomoto, Suguru, additional, Iwamoto, Hiroaki, additional, Yaegashi, Hiroshi, additional, Izumi, Kouji, additional, Kadono, Yoshifumi, additional, Nakata, Hiroki, additional, Saito, Yohei, additional, Goto, Masuo, additional, Nakagawa‐Goto, Kyoko, additional, and Mizokami, Atsushi, additional

Published
2021
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92. Similar Recurrence Rate Between Gleason Score of Six at Positive Margin and Negative Margin After Radical Prostatectomy

Author

KANO, HIROSHI, primary, KADONO, YOSHIFUMI, additional, KADOMOTO, SUGURU, additional, IWAMOTO, HIROAKI, additional, YAEGASHI, HIROSHI, additional, IIJIMA, MASASHI, additional, KAWAGUCHI, SHOHEI, additional, NOHARA, TAKAHIRO, additional, SHIGEHARA, KAZUYOSHI, additional, IZUMI, KOUJI, additional, IKEDA, HIROKO, additional, and MIZOKAMI, ATSUSHI, additional

Published
2021
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94. Sarcopenia and Visceral Metastasis at Cabazitaxel Initiation Predict Prognosis in Patients With Castration-resistant Prostate Cancer Receiving Cabazitaxel Chemotherapy

Author

IWAMOTO, HIROAKI, primary, KANO, HIROSHI, additional, SHIMADA, TAKAFUMI, additional, NAITO, RENATO, additional, MAKINO, TOMOYUKI, additional, KADOMOTO, SUGURU, additional, YAEGASHI, HIROSHI, additional, SHIGEHARA, KAZUYOSHI, additional, IZUMI, KOUJI, additional, KADONO, YOSHIFUMI, additional, and MIZOKAMI, ATSUSHI, additional

Published
2021
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100. Transvaginal polytetrafluoroethylene mesh surgery for pelvic organ prolapse: 1‐year clinical outcomes

Author

Kawaguchi, Shohei, primary, Narimoto, Kazutaka, additional, Hamuro, Akihiro, additional, Nakagawa, Tomomi, additional, Urata, Satoko, additional, Kadomoto, Suguru, additional, Iwamoto, Hiroaki, additional, Yaegashi, Hiroshi, additional, Iijima, Masashi, additional, Nohara, Takahiro, additional, Shigehara, Kazuyoshi, additional, Izumi, Kouji, additional, Tachibana, Daisuke, additional, Kadono, Yoshifumi, additional, Mizokami, Atsushi, additional, and Koyama, Masayasu, additional

Published
2020
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