51. Simple Aggregation‐Induced Emission‐Based Multifunctional Fluorescent Dots for Cancer Therapy In Vitro
- Author
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Pengju Feng, Fang Yang, Hongxing Liu, Tianfeng Chen, Junhao Zhao, Wei Huang, and Xueran Lin
- Subjects
Nanoparticle ,Apoptosis ,010402 general chemistry ,Endocytosis ,01 natural sciences ,Biochemistry ,Cell Line, Tumor ,Neoplasms ,Lysosome ,Quantum Dots ,Thiadiazoles ,medicine ,Humans ,Cytotoxicity ,Fluorescent Dyes ,Aniline Compounds ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,General Chemistry ,Fluorescence ,In vitro ,0104 chemical sciences ,medicine.anatomical_structure ,Benzaldehydes ,Biophysics ,Reactive Oxygen Species ,Intracellular - Abstract
Multifunctional nanoparticles were simply synthesized by mixing a TICT+AIE featured molecule (TPAPP-CHO) with PBS solution. The fluorescent (FL) dots entered the cells via energy-related endocytosis and were located in lysosome emitting green FL. This indicated that the nanoparticles were dissociated in the lysosome. Moreover, the synthesized nanoparticles (NPs) demonstrate potent cytotoxicity against human U87 glioblastoma cells by inducing cell apoptosis via triggering intracellular ROS overproduction.
- Published
- 2019