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54. Corrigendum: Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits

Author

Kim, Sung-Hee, primary, Kim, Jiseon, additional, Jang, Ji Yun, additional, Noh, Hyuna, additional, Park, Jisun, additional, Jeong, Haengdueng, additional, Jeon, Donghun, additional, Uhm, Chanyang, additional, Oh, Heeju, additional, Cho, Kyungrae, additional, Jeon, Yoon, additional, On, Dain, additional, Yoon, Suhyeon, additional, Lim, Soo-Yeon, additional, Kim, Sol Pin, additional, Lee, Youn Woo, additional, Jang, Hui Jeong, additional, Park, In Ho, additional, Oh, Jooyeon, additional, Seo, Jung Seon, additional, Kim, Jeong Jin, additional, Seok, Sang-Hyuk, additional, Lee, Yu Jin, additional, Hong, Seung-Min, additional, An, Se-Hee, additional, Kim, Seo Yeon, additional, Kim, Young Been, additional, Hwang, Ji-Yeon, additional, Lee, Hyo-Jung, additional, Kim, Hong Bin, additional, Choi, Kang-Seuk, additional, Park, Jun Won, additional, Seo, Jun-Young, additional, Yun, Jun-Won, additional, Shin, Jeon-Soo, additional, Lee, Ho-Young, additional, Kim, Kyoungmi, additional, Lee, Daekee, additional, Lee, Ho, additional, Nam, Ki Taek, additional, and Seong, Je Kyung, additional

Published
2022
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57. Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits

Author

Kim, Sung-Hee, primary, Kim, Jiseon, additional, Jang, Ji Yun, additional, Noh, Hyuna, additional, Park, Jisun, additional, Jeong, Haengdueng, additional, Jeon, Donghun, additional, Uhm, Chanyang, additional, Oh, Heeju, additional, Cho, Kyungrae, additional, Jeon, Yoon, additional, On, Dain, additional, Yoon, Suhyeon, additional, Lim, Soo-Yeon, additional, Kim, Sol Pin, additional, Lee, Youn Woo, additional, Jang, Hui Jeong, additional, Park, In Ho, additional, Oh, Jooyeon, additional, Seo, Jung Seon, additional, Kim, Jeong Jin, additional, Seok, Sang-Hyuk, additional, Lee, Yu Jin, additional, Hong, Seung-Min, additional, An, Se-Hee, additional, Kim, Seo Yeon, additional, Kim, Young Been, additional, Hwang, Ji-Yeon, additional, Lee, Hyo-Jung, additional, Kim, Hong Bin, additional, Choi, Kang-Seuk, additional, Park, Jun Won, additional, Seo, Jun-Young, additional, Yun, Jun-Won, additional, Shin, Jeon-Soo, additional, Lee, Ho-Young, additional, Kim, Kyoungmi, additional, Lee, Daekee, additional, Lee, Ho, additional, Nam, Ki Taek, additional, and Seong, Je Kyung, additional

Published
2022
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58. Comparison of the pathogenesis of SARS-CoV-2 infection in K18-hACE2 mouse and Syrian golden hamster models

Author

Jeong, Haengdueng, primary, Woo Lee, Youn, additional, Park, In Ho, additional, Noh, Hyuna, additional, Kim, Sung-Hee, additional, Kim, Jiseon, additional, Jeon, Donghun, additional, Jang, Hui Jeong, additional, Oh, Jooyeon, additional, On, Dain, additional, Uhm, Chanyang, additional, Cho, Kyungrae, additional, Oh, Heeju, additional, Yoon, Suhyeon, additional, Seo, Jung Seon, additional, Kim, Jeong Jin, additional, Seok, Sang-Hyuk, additional, Lee, Yu Jin, additional, Hong, Seung-Min, additional, An, Se-Hee, additional, Yeon Kim, Seo, additional, Kim, Young Been, additional, Hwang, Ji-Yeon, additional, Lee, Hyo-Jung, additional, Kim, Hong Bin, additional, Jeong, Dae Gwin, additional, Song, Daesub, additional, Song, Manki, additional, Park, Man-Seong, additional, Choi, Kang-Seuk, additional, Park, Jun Won, additional, Seo, Jun-Young, additional, Yun, Jun-Won, additional, Shin, Jeon-Soo, additional, Lee, Ho-Young, additional, Nam, Ki Taek, additional, and Seong, Je Kyung, additional

Published
2022
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61. Establishment of multicenter COVID-19 therapeutics preclinical test system in Republic of Korea

Author

Hyuna Noh, Suhyeon Yoon, Sung-Hee Kim, Jiseon Kim, Jung Seon Seo, Jeong Jin Kim, In Ho Park, Jooyeon Oh, Joon-Yong Bae, Gee Eun Lee, Sun-Je Woo, Sun-Min Seo, Na-Won Kim, Youn Woo Lee, Hui Jeong Jang, Seung-Min Hong, Se-Hee An, Kwang-Soo Lyoo, Minjoo Yeom, Hanbyeul Lee, Bud Jung, Sun-Woo Yoon, Jung-Ah Kang, Sang-Hyuk Seok, Yu Jin Lee, Seo Yeon Kim, Young Been Kim, Ji-Yeon Hwang, Dain On, Soo-Yeon Lim, Sol Pin Kim, Ji Yun Jang, Ho Lee, Kyoungmi Kim, Hyo-Jung Lee, Hong Bin Kim, Sun Bean Kim, Jun Won Park, Dae Gwin Jeong, Daesub Song, Kang-Seuk Choi, Ho-Young Lee, Yang-Kyu Choi, Jung-ah Choi, Manki Song, Man-Seong Park, Jun-Young Seo, Jeon-Soo Shin, Jun-Won Yun, Ki Taek Nam, and Je Kyung Seong

Subjects
Pulmonary and Respiratory Medicine, Biochemistry (medical), Pharmacology (medical)
Published
2023
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64. Development of a transient inline spiking system for evaluating virus clearance in continuous bioprocessing—Proof of concept for virus filtration

Author

Malakian, Anna, primary, Jung, Seon Yeop, additional, Afzal, Mohammad A., additional, Carbrello, Christina, additional, Giglia, Sal, additional, Johnson, Matthew, additional, Miller, Corinne, additional, Rayfield, William, additional, Boenitz, Dave, additional, Cetlin, David, additional, and Zydney, Andrew L., additional

Published
2022
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66. Efficacy of Transcartilaginous Electrodes for Intraoperative Neural Monitoring During Thyroid Surgery

Author

Jung, Seon Min, Tae, Kyung, Song, Chang Myeon, Lee, Seung Hwan, Jeong, Jin Hyeok, and Ji, Yong Bae

Subjects
recurrent laryngeal nerve, Recurrent laryngeal nerve palsy, medicine.medical_treatment, Laryngoscopy, lcsh:Medicine, Electromyography, 03 medical and health sciences, 0302 clinical medicine, Recurrent laryngeal nerve, Medicine, 030223 otorhinolaryngology, medicine.diagnostic_test, business.industry, Thyroid, lcsh:R, Thyroidectomy, electrode, Thyroid cartilage, lcsh:Otorhinolaryngology, lcsh:RF1-547, medicine.anatomical_structure, Otorhinolaryngology, 030220 oncology & carcinogenesis, thyroidectomy, Original Article, Surgery, intraoperative neurophysiological monitoring, business, Nuclear medicine, Intraoperative neurophysiological monitoring
Abstract

Objectives. This study was conducted evaluate the efficacy of electromyography (EMG) using transcartilaginous (TC) electrodes through the thyroid cartilage and perichondrium.Methods. We prospectively collected EMG data from intraoperative neuromonitoring (IONM) of 54 nerves at risk in 38 patients during thyroidectomy. We followed standardized IONM procedures in all operations. EMG signals from both endotracheal tube (ET) electrodes and TC needle electrodes were recorded simultaneously. We compared the characteristics of the EMG signals and the efficacy of both methods.Results. Significantly higher mean EMG amplitudes were recorded by TC electrodes than by ET electrodes in all four-step procedures (V1-R1-R2-V2, P

Published
2020

67. Age-Related Differences in Production of Non-Canonical Syntactic Structures as a Function of Modifiers to Noun Phrases

Author

Jung Seon Youn and Jee Eun Sung

Subjects
Linguistics and Language, business.industry, Communication, Function (mathematics), computer.software_genre, Noun phrase, Speech and Hearing, Non canonical, Age related, Production (computer science), Artificial intelligence, business, Psychology, computer, Natural language processing
Published
2020
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68. A new swallowing supplement for dysphagia in patients with Parkinson’s disease

Author

Eungseok Oh, Kanghee Cho, So Young Ahn, Sungju Jee, Beom Keun Kim, and Jung Seon Lee

Subjects
medicine.medical_specialty, Levodopa, Parkinson's disease, Neurology, Dermatology, 03 medical and health sciences, 0302 clinical medicine, Swallowing, Quality of life, otorhinolaryngologic diseases, Medicine, 030212 general & internal medicine, business.industry, digestive, oral, and skin physiology, General Medicine, medicine.disease, Dysphagia, Psychiatry and Mental health, Tolerability, Anesthesia, Neurology (clinical), Neurosurgery, medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Dysphagia associated with Parkinson's disease (PD) affects the mortality and quality of life of patients with PD. Avoiding aspiration and maintaining swallowing ability are among the concerns regarding PD care. Therefore, we developed a swallowing supplement for easier swallowing and tolerability in patients with PD. Thirty patients with PD and 50 healthy controls were enrolled and their swallowing function measured using the videofluoroscopic swallowing study (VFSS) and several dysphagia scales. The Unified Parkinson's Disease Rating Scale motor scores, Hoehn and Yahr stage, and levodopa doses were evaluated in patients with PD. The VFSS and survey were used to assess the viscosity, color, taste, nutrition, safety, and tolerability of the swallowing supplement. The MMSE score, serum albumin, and hemoglobin levels, and oral conditions were worse in the PD group than in the control group. Compared with controls, patients with PD had significantly lower total and sub-item scores of the swallowing quality of life (swal-QoL). Using commercialized yogurt, the pharyngeal delay time (PDT) and the modified penetration aspiration scale were higher in the PD group than in the control group. The swallowing supplement significantly shortened the PDT and pharyngeal transit time (PTT). Moreover, compared with commercialized yogurt, it improved pharyngeal wall coating, PTT, and aspiration in the videofluoroscopic dysphagia subscales. The survey scores were above average to good in the "easy swallowing" and "pharyngeal residual sense" items and tolerable in the remaining 6 preference items. This swallowing supplement could prevent aspiration and dysphagia complications in patients with PD.

Published
2020
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69. Additional file 2 of Broad humoral and cellular immunity elicited by one-dose mRNA vaccination 18 months after SARS-CoV-2 infection

Author

Kang, Chang Kyung, Shin, Hyun Mu, Choe, Pyoeng Gyun, Park, Jiyoung, Hong, Jisu, Seo, Jung Seon, Lee, Yung Hie, Chang, Euijin, Kim, Nam Joong, Kim, Minji, Kim, Yong-Woo, Kim, Hang-Rae, Lee, Chang-Han, Seo, Jun-Young, Park, Wan Beom, and Oh, Myoung-don

Subjects
body regions, fungi, skin and connective tissue diseases
Abstract

Additional file 2: Figure S2. Representative gating strategy for the SARS-CoV-2-specific activated and cytokine-producing T cells.

Published
2022
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70. Additional file 5 of Broad humoral and cellular immunity elicited by one-dose mRNA vaccination 18 months after SARS-CoV-2 infection

Author

Kang, Chang Kyung, Shin, Hyun Mu, Choe, Pyoeng Gyun, Park, Jiyoung, Hong, Jisu, Seo, Jung Seon, Lee, Yung Hie, Chang, Euijin, Kim, Nam Joong, Kim, Minji, Kim, Yong-Woo, Kim, Hang-Rae, Lee, Chang-Han, Seo, Jun-Young, Park, Wan Beom, and Oh, Myoung-don

Abstract

Additional file 5: Figure S4. Cytokine-producing T cells against wild-type SARS-CoV-2 and the Delta variant according to vaccination status after COVID-19. a CD4+ T-cell populations producing specific cytokines. b CD8+ T-cell populations producing specific cytokines. NS, not significant; IFN-γ, interferon- γ; IL, interleukin; TNF-α, tumor necrosis factor-α.

Published
2022
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71. A Longitudinal Molecular and Cellular Lung Atlas of Lethal SARS-CoV-2 Infection in K18-hACE2 Transgenic Mice

Author

Ho-Keun Kwon, Jusung Lee, Seunghoon Choi, Sujyeon Kim, Youn Woo Lee, Seung-Min Hong, Se-Hee An, Hyuna Noh, Kyung Eun Kim, Dain On, Sang Gyu Lee, Hui Jeong Jang, Sung-Hee Kim, Jiseon Kim, Jung Seon Seo, Jeong Jin Kim, In Ho Park, Jooyeon Oh, Jong-Hwi Yoon, Sang-Hyuk Seok, Yu Jin Lee, Seo Yeon Kim, Young Been Kim, Ji-Yeon Hwang, Hyo-Jung Lee, Hong Bin Kim, Jun Won Park, Jeon-Soo Shin, Jun-Young Seo, Ki Taek Nam, Kang-Seuk Choi, Ho-Young Lee, Jong Kyoung Kim, and Je Kyung Seong

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published
2022
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72. Additional file 3 of Broad humoral and cellular immunity elicited by one-dose mRNA vaccination 18 months after SARS-CoV-2 infection

Author

Kang, Chang Kyung, Shin, Hyun Mu, Choe, Pyoeng Gyun, Park, Jiyoung, Hong, Jisu, Seo, Jung Seon, Lee, Yung Hie, Chang, Euijin, Kim, Nam Joong, Kim, Minji, Kim, Yong-Woo, Kim, Hang-Rae, Lee, Chang-Han, Seo, Jun-Young, Park, Wan Beom, and Oh, Myoung-don

Abstract

Additional file 3: Table S1. Detailed clinical information of each group in the present study

Published
2022
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73. Additional file 1 of Broad humoral and cellular immunity elicited by one-dose mRNA vaccination 18 months after SARS-CoV-2 infection

Author

Kang, Chang Kyung, Shin, Hyun Mu, Choe, Pyoeng Gyun, Park, Jiyoung, Hong, Jisu, Seo, Jung Seon, Lee, Yung Hie, Chang, Euijin, Kim, Nam Joong, Kim, Minji, Kim, Yong-Woo, Kim, Hang-Rae, Lee, Chang-Han, Seo, Jun-Young, Park, Wan Beom, and Oh, Myoung-don

Abstract

Additional file 1: Figure S1. Purification of recombinant RBD proteins of SARS-CoV-2 variants. The purity of the purified recombinant protein was determined by non-reducing (left) and reducing (right) 14% SDS-PAGE gels. M, protein ladder. 1. RBD wild-type; 2. RBD Alpha (B.1.1.7, with N501Y mutation); 3. RBD Beta (B.1.351, with K417N, E484K, and N501Y); 4. RBD Gamma (P.1, with K417T, E484K, and N501Y mutations); 5. RBD Delta (B.1.617.2, with L452R and T478K mutations); 6. RBD Omicron (B. 1.1.529, with G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, and Y505H).

Published
2022
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74. Additional file 4 of Broad humoral and cellular immunity elicited by one-dose mRNA vaccination 18 months after SARS-CoV-2 infection

Author

Kang, Chang Kyung, Shin, Hyun Mu, Choe, Pyoeng Gyun, Park, Jiyoung, Hong, Jisu, Seo, Jung Seon, Lee, Yung Hie, Chang, Euijin, Kim, Nam Joong, Kim, Minji, Kim, Yong-Woo, Kim, Hang-Rae, Lee, Chang-Han, Seo, Jun-Young, Park, Wan Beom, and Oh, Myoung-don

Abstract

Additional file 4: Figure S3. Comparisons of humoral and cellular immune responses against different strains of SARS-CoV-2 in individuals who recovered and then received one dose of an mRNA vaccine 18 months later. a IgG-binding activities measured using an enzyme-linked immunosorbent assay. b Neutralization activities measured using a focus reduction neutralization test. c Proportions of activation-induced marker+ T cells measured by flow cytometric analysis. For simplicity, in Figure S3a, statistical significance is shown by the lines. * P < 0.05, ** P < 0.005 NS, not significant; FRNT, focus reduction neutralizing test.

Published
2022
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76. A Longitudinal Molecular and Cellular Lung Atlas of Lethal SARS-CoV-2 Infection in K18-hACE2 Transgenic Mice

Author

Kwon, Ho-Keun, primary, Lee, Jusung, additional, Choi, Seunghoon, additional, Kim, Sujyeon, additional, Lee, Youn Woo, additional, Hong, Seung-Min, additional, An, Se-Hee, additional, Noh, Hyuna, additional, Kim, Kyung Eun, additional, On, Dain, additional, Lee, Sang Gyu, additional, Jang, Hui Jeong, additional, Kim, Sung-Hee, additional, Kim, Jiseon, additional, Seo, Jung Seon, additional, Kim, Jeong Jin, additional, Park, In Ho, additional, Oh, Jooyeon, additional, Yoon, Jong-Hwi, additional, Seok, Sang-Hyuk, additional, Lee, Yu Jin, additional, Kim, Seo Yeon, additional, Kim, Young Been, additional, Hwang, Ji-Yeon, additional, Lee, Hyo-Jung, additional, Kim, Hong Bin, additional, Park, Jun Won, additional, Shin, Jeon-Soo, additional, Seo, Jun-Young, additional, Nam, Ki Taek, additional, Choi, Kang-Seuk, additional, Lee, Ho-Young, additional, Kim, Jong Kyoung, additional, and Seong, Je Kyung, additional

Published
2022
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85. Combinatorial Antitumor Activity of Oxaliplatin with Epigenetic Modifying Agents, 5-Aza-CdR and FK228, in Human Gastric Cancer Cells

Author

Hyo-Jeong Kuh, Suk Kyeong Lee, Kenneth K. Chan, Jung Seon Seo, and Jong Kook Park

Subjects
0301 basic medicine, Combinatorial index, Biochemistry, DNA methyltransferase, law.invention, 03 medical and health sciences, 0302 clinical medicine, EBV, law, Drug Discovery, medicine, Cytotoxic T cell, Epigenetics, Antagonism, Pharmacology, biology, Chemistry, Synergism, Oxaliplatin, 030104 developmental biology, Histone, Cell culture, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, biology.protein, Molecular Medicine, Suppressor, Original Article, Zta, medicine.drug
Abstract

Epigenetic silencing is considered to be a major mechanism for loss of activity in tumor suppressors. Reversal of epigenetic silencing by using inhibitors of DNA methyltransferase (DNMT) or histone deacetylases (HDACs) such as 5-Aza-CdR and FK228 has shown to enhance cytotoxic activities of several anticancer agents. This study aims to assess the combinatorial effects of gene-silencing reversal agents (5-Aza-CdR and FK228) and oxaliplatin in gastric cancer cells, i.e., Epstein-Barr virus (EBV)-negative SNU-638 and EBV-positive SNU-719 cells. The doublet combinatorial treatment of 5-Aza-CdR and FK228 exhibited synergistic effects in both cell lines, and this was further corroborated by Zta expression induction in SNU-719 cells. Three drug combinations as 5-Aza-CdR/FK228 followed by oxaliplatin, however, resulted in antagonistic effects in both cell lines. Simultaneous treatment with FK228 and oxaliplatin induced synergistic and additive effects in SNU-638 and SNU-719 cells, respectively. Three drug combinations as 5-Aza-CdR prior to FK228/oxaliplatin, however, again resulted in antagonistic effects in both cell lines. This work demonstrated that efficacy of doublet synergistic combination using DNMT or HDACs inhibitors can be compromised by adding the third drug in pre- or post-treatment approach in gastric cancer cells. This implies that the development of clinical trial protocols for triplet combinations using gene-silencing reversal agents should be carefully evaluated in light of their potential antagonistic effects.

Published
2018
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86. Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila.

Author

Lark Kyun Kim, Un Yung Choi, Hwan Sung Cho, Jung Seon Lee, Wook-bin Lee, Jihyun Kim, Kyoungsuk Jeong, Jaewon Shim, Jeongsil Kim-Ha, and Young-Joon Kim

Subjects
Biology (General), QH301-705.5
Abstract

The activation of several transcription factors is required for the elimination of infectious pathogens via the innate immune response. The transcription factors NF-kappaB, AP-1, and STAT play major roles in the synthesis of immune effector molecules during innate immune responses. However, the fact that these immune responses can have cytotoxic effects requires their tight regulation to achieve restricted and transient activation, and mis-regulation of the damping process has pathological consequences. Here we show that AP-1 and STAT are themselves the major inhibitors responsible for damping NF-kappaB-mediated transcriptional activation during the innate immune response in Drosophila. As the levels of dAP-1 and Stat92E increase due to continuous immune signaling, they play a repressive role by forming a repressosome complex with the Drosophila HMG protein, Dsp1. The dAP-1-, Stat92E-, and Dsp1-containing complexes replace Relish at the promoters of diverse immune effector genes by binding to evolutionarily conserved cis-elements, and they recruit histone deacetylase to inhibit transcription. Reduction by mutation of dAP-1, Stat92E, or Dsp1 results in hyperactivation of Relish target genes and reduces the viability of bacterially infected flies despite more efficient pathogen clearance. These defects are rescued by reducing the Relish copy number, thus confirming that mis-regulation of Relish, not inadequate activation of dAP-1, Stat92E, or Dsp1 target genes, is responsible for the reduced survival of the mutants. We conclude that an inhibitory effect of AP-1 and STAT on NF-kappaB is required for properly balanced immune responses and appears to be evolutionarily conserved.

Published
2007
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97. The Effects of Characteristics of Mobile Coupon on the User’s Perceived Usefulness and Intention of Use Mobile Coupon

Author

Jung Seon Mi, Hyun Gyu Kim, and Kim Young Hoon

Subjects
business.industry, 05 social sciences, Internet privacy, Intention to use, Advertising, 02 engineering and technology, 020204 information systems, 0502 economics and business, 0202 electrical engineering, electronic engineering, information engineering, General Earth and Planetary Sciences, 050211 marketing, Coupon, business, General Environmental Science
Published
2016
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98. Comparison of core-needle biopsy and repeat fine-needle aspiration for thyroid nodules with inconclusive initial cytology.

Author

Jung, Seon Min, Koo, Hye Ryoung, Jang, Ki Seok, Chung, Min Sung, Song, Chang Myeon, Ji, Yong Bae, Park, Jeong Seon, and Tae, Kyung

Subjects
*NEEDLE biopsy, *THYROID nodules, *CYTOLOGY
Abstract

Purpose: We aimed to compare the efficacy of ultrasound-guided core-needle biopsy (CNB) with repeat fine-needle aspiration (rFNA) cytology in thyroid nodules with inconclusive results in initial fine-needle aspiration cytology. Methods: We studied 402 patients who required a repeat biopsy of thyroid nodules using ultrasound-guided CNB (n = 192) or rFNA (n = 210) because of inconclusive results in initial FNA, corresponding to categories I, III, and IV of the Bethesda System for Reporting Thyroid Cytopathology. If repeat biopsy results were benign (category II), suspicious malignancy (category V), or malignancy (category VI), they were defined as "diagnostic results". The diagnostic yield and performances of repeat biopsy were analyzed and compared between the rFNA and CNB groups. Results: The diagnostic results were obtained significantly higher in the CNB group than in the rFNA group (72.4% vs. 52.4%; P < 0.001). In the subgroup analysis, the diagnostic results were significantly higher in the CNB group than in the rFNA group for patients of categories I and III (P < 0.001 in both) in initial FNA. However, in patients with category IV nodules, there were no significant differences in diagnostic results between the two groups (P = 0.46). Conclusion: Compared to rFNA, ultrasound-guided CNB is useful and effective as a repeat biopsy option for thyroid nodules with non-diagnostic results (category I) and atypia of undetermined significance (AUS) or follicular lesion of undetermined significance (FLUS) (category III) in initial FNA. [ABSTRACT FROM AUTHOR]

Published
2021
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