51. In vitro susceptibilities of bloodstream isolates of Candida species to six antifungal agents: results from a population-based active surveillance programme, Barcelona, Spain, 2002-2003
- Author
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Dolores Rodríguez, Manuel Cuenca-Estrella, Albert Pahissa, Juliette Morgan, David W. Warnock, Montserrat Giménez, Benito Almirante, Josefina Ayats, Juan L. Rodriguez-Tudela, Ana María Planes, José Mensa, Manel Almela, Margarita Salvadó, and Ferran Sanchez
- Subjects
Microbiology (medical) ,Antifungal Agents ,Antifungal drug ,Microbial Sensitivity Tests ,Candida parapsilosis ,Microbiology ,Candida tropicalis ,chemistry.chemical_compound ,Drug Resistance, Fungal ,Candida krusei ,medicine ,Humans ,Pharmacology (medical) ,Candida albicans ,Candida ,Pharmacology ,Voriconazole ,biology ,Candida glabrata ,biology.organism_classification ,Infectious Diseases ,Blood ,chemistry ,Spain ,Population Surveillance ,Caspofungin ,medicine.drug - Abstract
Received 25 August 2004; returned 20 October 2004; revised 22 November 2004; accepted 23 November 2004Objectives: The antifungal drug susceptibilities of 351 isolates of Candida species, obtained throughactive laboratory-based surveillance in the period January 2002–December 2003, were determined(Candida albicans 51%, Candida parapsilosis 23%, Candida tropicalis 10%, Candida glabrata 9%,Candida krusei 4%).Methods: The MICs of amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole andcaspofungin were established by means of the broth microdilution reference procedure of theEuropean Committee on Antibiotic Susceptibility Testing.Results and conclusions: Amphotericin B and flucytosine were active in vitro against all strains. A totalof 24 isolates (6.8%) showed decreased susceptibility to fluconazole (MIC>_ 16mg/L) and 43 (12.3%)showed decreased susceptibility to itraconazole (MIC>_ 0.25mg/L). Voriconazole and caspofungin wereactive in vitro against the majority of isolates, even those that were resistant to fluconazole.Keywords: fluconazole resistance, caspofungin, voriconazole, EUCAST
- Published
- 2004