344 results on '"Jonathan Lewis"'
Search Results
52. User strategies for handling information tasks in webcasts.
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Christine Dufour, Elaine G. Toms, Jonathan Lewis, and Ronald Baecker
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- 2005
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53. Introduction
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Jonathan Lewis and Antonia Wimbush
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- 2021
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54. Impossible reconciliation? The representation of traumatic memories in La meilleure façon de s’aimer (2012) by Akli Tadjer
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Jonathan, Lewis, primary
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- 2022
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55. Predicting treatment-resistance from first-episode psychosis using routinely collected clinical information: development and external validation study
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Emanuele Osimo, Benjamin Perry, Pavan Mallikarjun, Megan Pritchard, Jonathan Lewis, Asia Katunda, Graham Murray, Jesus Perez, Peter Jones, Rudolf Cardinal, Oliver Howes, Rachel Upthegrove, and Golam Khandaker
- Abstract
Around a quarter of people who experience a first episode of psychosis (FEP) will develop treatment-resistant schizophrenia (TRS), but there are currently no established clinically useful methods to predict this from baseline. We aimed to explore the predictive potential for clozapine use as a proxy for TRS of routinely collected, objective biomedical predictors at FEP onset, and to externally validate the model in a separate clinical sample of people with FEP. We developed and externally validated two risk prediction models to predict up to 8-year risk of clozapine use from FEP using routinely recorded information including age, sex, ethnicity, triglycerides, alkaline phosphatase levels, and lymphocyte counts in forced-entry logistic regression models. We also produced a least-absolute shrinkage and selection operator (LASSO) based model, additionally including neutrophil count, smoking status, body mass index, and random glucose levels. The models were developed using data from two UK psychosis early intervention services (EIS) and externally validated in another UK EIS. Model performance was assessed via discrimination and calibration. We developed the models in 785 patients, and validated externally in 1,110 patients. Both models predicted clozapine use well at internal validation (forced-entry: C 0.70; 95%CI 0.63,0.76; LASSO: 0.69; 95%CI 0.63,0.77). At external validation, discrimination performance reduced (forced-entry: 0.63; 0.58,0.69; LASSO: 0.64; 0.58,0.69) but recovered after re-estimation of the lymphocyte predictor (C: 0.67; 0.62,0.73). Calibration plots showed good agreement between observed and predicted risk in the forced-entry model. We also present a decision-curve analysis and an online data visualisation tool. The use of routinely collected clinical information including blood-based biomarkers taken at FEP onset can help to predict the individual risk of clozapine use, and should be considered equally alongside other potentially useful information such as symptom scores in large-scale efforts to predict psychiatric outcomes.
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- 2022
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56. Quantum MMIC: future and applications in RF circuits.
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Nada El-Zein, Mandar Deshpande, Gary Kramer, Jonathan Lewis, Vijay Nair, Marilyn Kyler, and Herb Goronkin
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- 2000
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57. Mid‐Holocene environmental change and human occupation at Sai Island, Northern Sudan
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Katherine A. Adelsberger, Jonathan Lewis, Elena A. A. Garcea, Danika N. Hill, J. P. Dodd, and Jennifer R. Smith
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Archeology ,Environmental change ,Pastoralism ,stable isotopes ,Nile Valley ,environmental change ,Sudan ,environmental change, Nile Valley, pastoralism, pedogenic carbonate, stable isotopes, Sudan ,Earth and Planetary Sciences (miscellaneous) ,Physical geography ,pedogenic carbonate ,pastoralism ,Holocene ,Geology - Published
- 2020
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58. Can an Integrated Constructed Wetland in Norfolk Reduce Nutrient Concentrations and Promote In Situ Bird Species Richness?
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Jonah Tosney, Olly van Biervliet, Jonathan Lewis-Phillips, and Robert J. McInnes
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010504 meteorology & atmospheric sciences ,Ecology ,Aquatic ecosystem ,010501 environmental sciences ,01 natural sciences ,chemistry.chemical_compound ,Nutrient ,Animal science ,Nitrate ,chemistry ,Constructed wetland ,Environmental Chemistry ,Environmental science ,Sewage treatment ,Ammoniacal nitrogen ,Nitrite ,Effluent ,0105 earth and related environmental sciences ,General Environmental Science - Abstract
Integrated Constructed Wetlands (ICWs) are potentially effective tools in the effort to restore aquatic ecosystems, and also they incorporate multiple co-benefits. An ICW was constructed in Norfolk, UK, to address the degradation of a stream and lake receiving treated effluent from a small Sewage Treatment Works (STW). Results demonstrated that: (1) nutrient concentrations significantly reduced from the ICW influent to the effluent (percentage reductions: total phosphorus [TP]: 78%, orthophosphate: 80%, total oxidised nitrogen [TON]: 65%, nitrate: 65%, nitrite: 67%, ammoniacal nitrogen: 62%), and mean dissolved oxygen concentrations increased (influent mean: 6.4 ± 1.4 mg l−1effluent mean: 17.8 ± 3.3 mg l−1), (2) there were non-significant reductions in nutrient concentrations in the receiving stream (percentage reductions: TP: 23%, orthophosphate: 23%, TON: 26%, nitrate: 26%), with the exception of ammoniacal nitrogen (127% increase) and nitrite (76%) after ICW commissioning, and (3) mean in situ avian species richness increased from 10 to 27 species. Thus, the ICW substantially reduced nutrient concentrations, and had in situ conservation benefits. It is recommended that appropriately designed ICWs should be implemented widely and statutory authorities should ensure: 1) best-practice maintenance and 2) final effluent monitoring at both the STW and at the ICW outflows.
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- 2020
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59. Sulfur and Hafnium Isotope evidence for Early Horizontal Tectonics in Eoarchean Peridotites
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Jonathan Lewis, J. Elis Hoffmann, Esther M. Schwarzenbach, Harald Strauss, Chunhui Li, Carsten Münker, and Minik T. Rosing
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The origins of Eoarchean peridotites found in the Itsaq Gneiss Complex (IGG) of southern West Greenland represent a crucial record of igneous and geodynamic processes on the early Earth. The igneous and geodynamic origins of these rocks have, however, been the subject of controversy, with some researchers arguing that they represent the first known slivers of mantle emplaced by tectonic processes in the crust and others contending that they represent cumulates associated with the local basalt units. The geodynamic context for the formation of these rocks has also been disputed, with some researchers arguing that they formed in a horizontal tectonic setting analogous to a modern subduction zone, while others propose a vertical tectonic origin for all Eoarchean rocks. Here, we provide new insights into the history of these peridotites using multiple sulfur isotope signatures combined with Hf isotope compositions. Anomalously high εΗf values in some IGC peridotites identified in previous studies [1], as well as in metabasalts with boninite-like compositions [2] found in the Isua Supracrustal Belt (ISB) within the IGC, point to contributions from a mantle source already depleted in the Hadean [2]. The multiple sulfur isotope data of the IGC peridotites found south of the ISB reveal small but significant Δ33S anomalies, consistent with incorporation of surface-derived material of Archean age or older. Furthermore, correlations between sulfur isotope data and major and trace element abundances as well as initial Hf isotope values of IGC peridotites support the hypothesis that high-degree melt depletion occurred under hydrous conditions, followed by variable degrees of melt metasomatism. The involved fluid and melt components precipitated sulfides that incorporated surface-derived sulfur with different depositional origins. We propose that these findings are best explained by a horizontal tectonic regime similar to modern arc settings. 1. van de Löcht, J., et al., Preservation of Eoarchean mantle processes in ∼3.8 Ga peridotite enclaves in the Itsaq Gneiss Complex, southern West Greenland. Geochimica et Cosmochimica Acta, 2020. 280: p. 1-25.2. Hoffmann, J.E., et al., Highly depleted Hadean mantle reservoirs in the sources of early Archean arc-like rocks, Isua supracrustal belt, southern West Greenland. Geochimica et Cosmochimica Acta, 2010. 74(24): p. 7236-7260.
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- 2022
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60. The first high-resolution curved waveguide with replicated eye-boxes, encapsulated in spectacle lenses
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Andrey Volkov and Jonathan Lewis
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- 2022
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61. Experimental philosophical bioethics and normative inference
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Brian D. Earp, Ivar R. Hannikainen, Jonathan Lewis, and Vilius Dranseika
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Moral judgment ,Inference ,Context (language use) ,Morals ,0603 philosophy, ethics and religion ,Article ,Judgment ,Situated ,Moral psychology ,Humans ,Sociology ,Empirical bioethics ,Experimental philosophical bioethics ,06 humanities and the arts ,General Medicine ,Bioethics ,16. Peace & justice ,Normative inference ,Epistemology ,Philosophy ,Issues, ethics and legal aspects ,Philosophy of medicine ,060302 philosophy ,Normative ,060301 applied ethics ,Ethical Theory ,Experimental philosophy - Abstract
We are immensely grateful to Joshua Knobe for his dedication to this project, as well as his support, guidance, and invaluable comments and suggestions during the writing process. We also gratefully acknowledge the respective contributions of the two anonymous reviewers, and we wish to thank Katelyn MacDougald for doing such a stellar job editing the manuscript as well as Kristien Hens and Andreas De Block for inviting us to contribute to this special issue., This paper explores an emerging sub-field of both empirical bioethics and experimental philosophy, which has been called “experimental philosophical bioethics” (bioxphi). As an empirical discipline, bioxphi adopts the methods of experimental moral psychology and cognitive science; it does so to make sense of the eliciting factors and underlying cognitive processes that shape people’s moral judgments, particularly about real-world matters of bioethical concern. Yet, as a normative discipline situated within the broader field of bioethics, it also aims to contribute to substantive ethical questions about what should be done in a given context. What are some of the ways in which this aim has been pursued? In this paper, we employ a case study approach to examine and critically evaluate four strategies from the recent literature by which scholars in bioxphi have leveraged empirical data in the service of normative arguments.
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- 2022
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62. What should recognition entail? Responding to the reification of autonomy and vulnerability in medical research
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Jonathan Lewis and Soren Holm
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Issues, ethics and legal aspects ,Health (social science) ,Arts and Humanities (miscellaneous) ,Health Policy - Abstract
Smajdor argues that “recognition” is the solution to the “reifying attitude” that results from “the urge to protect ‘vulnerable’ people through exclusion from research”. Drawing on theories of reification, we argue that it is the concepts of autonomy and vulnerability themselves that have been reified, resulting in the impoverishment of approaches to autonomy at law and in research ethics. Overcoming such reification demands a deeper consideration of the grounds on which vulnerable individuals are owed recognition and thereby the forms such recognition should take. Smajdor argues for a recognition that appeals to autonomy and that manifests in providing vulnerable individuals with the opportunity to assent. The problem is that this kind of recognition is dependent on a more fundamental kind. It is this second form of recognition that would need to do the heavy lifting for assent-based frameworks to avoid the same problems we find with consent.
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- 2023
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63. A Comparison of Dominance Mechanisms and Simple Mutation on Non-stationary Problems.
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Jonathan Lewis, Emma Hart, and Graeme Ritchie
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- 1998
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64. Virulence Factor Regulation in Listeria monocytogenes
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Portman, Jonathan Lewis
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Microbiology ,Molecular biology ,Immunology ,Glutathione ,Listeria ,Pathogenesis ,PrfA ,Redox ,Virulence - Abstract
Listeria monocytogenes is a Gram-positive intracellular pathogen that is readily amenable to genetic manipulation and for which there are excellent in vitro and in vivo virulence models. These attributes have allowed a thorough examination of the molecular underpinnings of L. monocytogenes pathogenesis, however, there are still a number of major unresolved questions that remain to be answered. For example, it has been known for many years that L. monocytogenes rapidly changes its transcriptional profile upon access to the host cytosol, however the host cues and bacterial components that are involved in driving this change have remained continually unanswered. One large piece of evidence came when the long-sought co-factor for the primary virulence regulator, PrfA, was discovered to be the antioxidant tripeptide, glutathione. Glutathione was demonstrated to play a crucial role in the activation of PrfA in vivo— a finding that has since led to two important discoveries that are described herein. First, the activation of PrfA in vitro requires both exogenous glutathione and a metabolic licensing step that can be recapitulated by a chemically defined synthetic media. Second, glutathione also functions as a post-translational regulator of the pore-forming virulence factor, Listeriolysin O (LLO), by reversibly binding via an S-glutathionylation reaction and preventing membrane association of the LLO monomers. These discoveries elucidate numerous regulatory roles for glutathione during infection and describe how L. monocytogenes is able to sense and respond to critical host compartments to mount a successful infection.Upon entry to the host cell cytosol, the facultative intracellular pathogen Listeria monocytogenes coordinates the expression of numerous essential virulence factors by allosteric binding of glutathione (GSH) to the Crp-Fnr family transcriptional regulator, PrfA. Here we report that robust virulence gene expression can be recapitulated by growing bacteria in a synthetic medium (iLSM) containing GSH or other chemical reducing agents. Bacteria grown under these conditions were 45-fold more virulent in an acute murine infection model and conferred greater immunity to a subsequent lethal challenge compared to bacteria grown in conventional media. During cultivation in vitro, PrfA activation was completely dependent on intracellular levels of GSH, as a glutathione synthase mutant (∆gshF) was activated by exogenous GSH but not reducing agents. PrfA activation was repressed in iLSM supplemented with oligopeptides, but suppression was relieved by stimulation of the stringent response. These data suggest that cytosolic L. monocytogenes interpret a combination of metabolic and redox cues as a signal to initiate robust virulence gene expression in vivo.Cholesterol-dependent cytolysins (CDCs) represent a family of homologous pore-forming proteins secreted by many Gram-positive bacterial pathogens. CDCs mediate membrane binding partly through a conserved C-terminal undecapeptide, which contains a single cysteine residue. While mutational changes to other residues in the undecapeptide typically have severe effects, mutating the cysteine residue to alanine has minor effects on overall protein function. Thus, the function of this highly conserved reactive cysteine residue remains largely unknown. We report here that the CDC Listeriolysin O (LLO), secreted by the facultative intracellular pathogen Listeria monocytogenes, was post-translationally modified by a S-glutathionylation at this conserved cysteine residue, and that either endogenously synthesized or exogenously added glutathione was sufficient to form this modification. When recapitulated with purified protein in vitro, this modification completely ablated the activity of LLO, and this inhibitory effect was fully reversible by treatment with reducing agents. A cysteine-to-alanine mutation in LLO rendered the protein completely resistant to inactivation by S-glutathionylation and retained full hemolytic activity. A mutant strain of L. monocytogenes expressing the cysteine-to-alanine variant of LLO was able to infect and replicate within bone marrow-derived macrophages indistinguishably from wild-type in vitro, yet was attenuated 4-6 fold in a competitive murine infection model in vivo. This study suggests that S-glutathionylation may represent a mechanism by which CDC family proteins are post-translationally modified and regulated, and help explain an evolutionary pressure behind the highly conserved undecapeptide cysteine.
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- 2017
65. Investigating the organofluorine physiology of Streptomyces cattleya: Regulation of transcription and control of mistranslation
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McMurry, Jonathan Lewis
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Biochemistry ,Microbiology ,Analytical chemistry ,aminoacyl-tRNA synthetase ,fluorothreonine - Abstract
The soil-dwelling bacterium Streptomyces cattleya produces the antibiotics fluoroacetate and fluorothreonine, and has served as a model system for the discovery of naturally occurring fluorine-selective biochemistry. While fluoroacetate has long been known to act as an inhibitor of the TCA cycle, the fate of the amino acid fluorothreonine is still not well understood. Here, I show that while fluorothreonine is a substrate for translation, this activity is averted in S. cattleya by the activity of two conserved proteins. The first, SCAT_p0564, acts in vitro and in vivo as a fluorothreonyl-tRNA selective hydrolase, while the second, SCAT_p0565, is proposed to be a fluorothreonine exporter. Additionally, overexpression of SCAT_p0564 in the model strain Streptomyces coelicolor M1152 confers resistance to fluorothreonine, suggesting that the antibiotic activity of this compound is related in part to its ability to enter the proteome. The ability of SCAT_p0564 to selectively hydrolyze fluorothreonyl- over threonyl-tRNA is striking, given that these macromolecular substrates differ by a single atom. In order to understand the basis of this selectivity, I have solved the crystal structure of this enzyme, and characterized its ability to act on the related substrate chlorothreonyl-tRNA. I also have also begun to elucidate the regulatory architecture of the organofluorine biosynthesis locus, with the aim of understanding how this unusual process is controlled. I find that transcription of the fluorinase is driven by the master regulator FlG, while FlF is an amino acid binding transcription factor that may be required for full expression of the fluorothreonine transaldolase. These findings expand the range of known naturally occurring fluorine biochemistry, and a represent a step towards the rational discovery of new organofluorine metabolism in nature.
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- 2017
66. Pathways to Drug Liberalization: Racial Justice, Public Health, and Human Rights
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Brian D. Earp, Carl L. Hart, and Jonathan Lewis
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medicine.medical_specialty ,Human Rights ,Human rights ,Liberalization ,media_common.quotation_subject ,Health Policy ,Public health ,Racial Groups ,Public administration ,Drug policy reform ,Economic Justice ,Health Services Accessibility ,Issues, ethics and legal aspects ,Racism ,Social Justice ,Political science ,medicine ,Humans ,Public Health ,media_common - Abstract
In our recent article, together with more than 60 of our colleagues, we outlined a proposal for drug policy reform consisting of four specific yet interrelated strategies: (1) de jure decriminalization of all psychoactive substances currently deemed illicit for personal use or possession (so-called “recreational” drugs), accompanied by harm reduction policies and initiatives akin to the Portugal model; (2) expunging criminal convictions for nonviolent offenses pertaining to the use or possession of small quantities of such drugs (and releasing those serving time for these offenses), while delivering retroactive ameliorative relief; (3) the ultimate legalization and careful regulation of currently illicit drugs; and (4) the delivery of a new “Marshall Plan” focused on community-building initiatives, expanded harm reduction programs, and social and health care support efforts (Earp et al. 2021). We were gratified to see so many thoughtful commentaries on our proposal, and we respond to them in part in this reply.
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- 2021
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67. Equipoise, standard of care and consent: responding to the authorisation of new COVID-19 treatments in randomised controlled trials
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Jonathan Lewis, Søren Holm, and Rafael Dal-Re
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Issues, ethics and legal aspects ,Health (social science) ,Arts and Humanities (miscellaneous) ,Health Policy - Abstract
In response to the COVID-19 pandemic, large-scale research and pharmaceutical regulatory processes have proceeded at a dramatically increased pace with new and effective, evidence-based COVID-19 interventions rapidly making their way into the clinic. However, the swift generation of high-quality evidence and the efficient processing of regulatory authorisation have given rise to more specific and complex versions of well-known research ethics issues. In this paper, we identify three such issues by focusing on the authorisation of molnupiravir, a novel antiviral medicine aimed at reducing the ability of SARS-CoV-2 to multiply in the body, for clinical use by the National Health Service in England and the concomitant testing of molnupiravir through the large-scale Platform Adaptive trial of Novel antiviRals for eArly treatMent of COVID-19 In the Community randomised control trial. By analysing the ways in which the authorisation and clinical use of molnupiravir complicate standard approaches to clinical equipoise, standard of care and participant consent in the PANORAMIC randomised control trial, we will explain some of ethical implications for clinical trials that aim to study the efficacy and safety of new COVID-19 and other therapeutics when conditional authorisation has already been granted and when such treatments have already been made available to patients by national health providers.
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- 2022
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68. Experimental Philosophical Bioethics of Personal Identity
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Brian D. Earp, Jonathan Lewis, Joshua A. Skorburg, Ivar R. Hannikainen, Jim A. C. Everett, and Tobia, K. P.
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The question of what makes someone the same person through time and change has long been a preoccupation of philosophers. In recent years, the question of what makes ordinary or lay people judge that someone is—or isn’t—the same person has caught the interest of experimental psychologists. These latter, empirically oriented researchers have sought to understand the cognitive processes and eliciting factors that shape ordinary people’s judgments about personal identity and the self. Still more recently, practitioners within an emerging discipline, experimental philosophical bioethics or “bioxphi”—the focus of this chapter—have adopted a similar aim and employed similar methodologies, but with two distinctive features: (a) a special concern for enhanced ecological validity in the examples and populations studied; and (b) an interest in contributing to substantive normative debates within the wider field of bioethics. Our aim in this chapter is to sample illustrative work on personal identity in bioxphi, explore how it relates to studies in psychology covering similar terrain, and draw out the implications of this work for matters of bioethical concern. In pursuing these issues, we highlight recent work in bioxphi that includes the perceived validity of advance directives following neurodegeneration, the right of psychologically altered study participants to withdraw from research, how drug addiction may cause one to be regarded by others as “a completely different person,” the effect of deep-brain stimulation on perceptions of the self, and the potential influence of moral enhancement interventions on intuitive impressions of a person’s character.
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- 2022
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69. Transport Security and its Legal Regulation: European and Russian Experience
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Nikolai Kolesnikov and Jonathan Lewis
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History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
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70. Principlist Pandemics: On Fraud Ethical Guidelines, and the Importance of Procedural Transparency
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Jonathan Lewis and Udo Schuklenk
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- 2022
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71. Capturing and Promoting the Autonomy of Capacitous Vulnerable Adults
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Jonathan Lewis
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legal aspects ,Health (social science) ,Vulnerable adult ,media_common.quotation_subject ,Common law ,Vulnerability ,Medical law ,High Court ,0603 philosophy, ethics and religion ,Paternalism ,Arts and Humanities (miscellaneous) ,autonomy ,0505 law ,media_common ,050502 law ,Health Policy ,capacity ,05 social sciences ,informed consent ,06 humanities and the arts ,decision-making ,Issues, ethics and legal aspects ,060301 applied ethics ,Psychology ,Social psychology ,Autonomy ,Medical ethics - Abstract
According to the High Court in England and Wales, the primary purpose of legal interventions into the lives of vulnerable adults with mental capacity should be to allow the individuals concerned to regain their autonomy of decision-making. However, recent cases of clinical decision-making involving capacitous vulnerable adults have shown that, when it comes to medical law, medical ethics and clinical practice, vulnerability is typically conceived as opposed to autonomy. The first aim of this paper is to detail the problems that arise when the courts and healthcare practitioners respond to the vulnerability of capacitous adults on the basis of such an opposition. It will be shown that not only does the common law approach to vulnerability fail to adequately capture the autonomy of capacitous vulnerable adults, the conception of vulnerability and autonomy in oppositional terms leads to objectionably paternalistic healthcare responses that undermine the autonomy of vulnerable patients as well as clinical and legal interventions that violate their autonomy. In response, the second aim of this paper is to show that the concepts of autonomy and vulnerability arenecessarilyentwined and, on that basis, the focus should be on promoting the autonomy of capacitous vulnerable adultswhere possible. In order to make this case, the paper explains the limitations of standard approaches to the autonomy of vulnerable adults and, in their place, offers a conception of legitimate, self-authorised autonomy that is fundamentally dependent on intersubjective practices of recognition.
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- 2021
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72. Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy
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Rebecca A. Ellwood, Luke Slade, Jonathan Lewis, Roberta Torregrossa, Surabhi Sudevan, Mathew Piasecki, Matthew Whiteman, Timothy Etheridge, and Nathaniel J. Szewczyk
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Muscular Dystrophy, Duchenne ,Dietary Supplements ,Medicine (miscellaneous) ,Animals ,Cysteine ,General Agricultural and Biological Sciences ,Caenorhabditis elegans ,General Biochemistry, Genetics and Molecular Biology ,Sulfur - Abstract
Mutations in the dystrophin gene cause Duchenne muscular dystrophy (DMD), a common muscle disease that manifests with muscle weakness, wasting, and degeneration. An emerging theme in DMD pathophysiology is an intramuscular deficit in the gasotransmitter hydrogen sulfide (H2S). Here we show that the C. elegans DMD model displays reduced levels of H2S and expression of genes required for sulfur metabolism. These reductions can be offset by increasing bioavailability of sulfur containing amino acids (L-methionine, L-homocysteine, L-cysteine, L-glutathione, and L-taurine), augmenting healthspan primarily via improved calcium regulation, mitochondrial structure and delayed muscle cell death. Additionally, we show distinct differences in preservation mechanisms between sulfur amino acid vs H2S administration, despite similarities in required health-preserving pathways. Our results suggest that the H2S deficit in DMD is likely caused by altered sulfur metabolism and that modulation of this pathway may improve DMD muscle health via multiple evolutionarily conserved mechanisms.
- Published
- 2021
73. Rational Approach to Assess the Effect of Corrosion on Stiffened Panel Buckling and Ultimate Capacity
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Nikhil Prakash Joshi, Jonathan Lewis Brewer, and Christopher John Rose
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Materials science ,Buckling ,business.industry ,Structural engineering ,business ,Corrosion - Abstract
During the annual In-Service Inspection of a spar hull, several regions of pitting corrosion on the upper portion of the north and south moon pool external wall plating were identified. The moon pool walls are constructed as typical stiffened panel structures. Visual, ultrasonic (UT), and pulsed eddy current (PEC) inspections indicated regions of corrosion with roughly 40% to 70% averaged localized wall loss. This paper discusses the analytical assessment of the structure to determine the effect of the corrosion on the structural integrity of the moon pool wall and any similar structural panel. To determine the impact of corrosion on the stiffened panel integrity, a finite element (FE) based analysis approach is used to perform a comparative assessment of the "as-built" and "corroded" configuration of the moon pool wall. The nominal plate and stiffener thicknesses are modeled in the "as-built" configuration; whereas, the measured plate thickness from the inspection is modeled in the "corroded" configuration. The structure is subjected to design loads based on the storm damaged design condition. The analysis is performed by uniformly increasing the applied loads until failure occurs, maintaining a constant ratio between the nominal loads. Two different analyses are performed as a part of the strength assessment: (1) a linear-elastic eigenvalue analysis to estimate the elastic buckling capacity and mode shapes of the structure and (2) an elastic-plastic post-buckling analysis to estimate the ultimate capacity of the structure. In addition, the results from the linear-elastic eigenvalue analysis are compared to the results from analytical buckling calculations. The analysis results indicate that the corrosion reduces the elastic plate buckling capacity significantly. However, the overall capacity of the stiffened panel is not significantly reduced. Therefore, from a global strength perspective, the stiffened panel remains acceptable in its corroded condition. The upper portion of the moon pool wall is typically fatigue insensitive in spars. Therefore, the effect of the corrosion wall loss on the fatigue performance was not assessed. Since there is limited guidance in design and assessment codes for assessing corroded stiffened panels, this approach can be used to address future stiffened panel corrosion wall loss. In addition, this method allows for inclusion of future corrosion allowance, if applicable. Determining the capacity of corroded panels using FEA-based numerical methods, like those described in this paper, allows the operators to manage their risks, repair costs, and inspection frequency by determining the actual capacity of the damaged components. This allows the operators to determine the appropriate mitigation measures based on a quantitative risk calculation.
- Published
- 2021
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74. Féroces infirmes
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Jonathan Lewis
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Political Science and International Relations ,Geography, Planning and Development ,Development - Published
- 2020
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75. How Transdisciplinary is Design? An Analysis Using Citation Networks
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Jonathan Lewis
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Body of knowledge ,Citation network ,Arts and Humanities (miscellaneous) ,Computer science ,InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL ,Network science ,Citation ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,Computer Graphics and Computer-Aided Design ,Data science - Abstract
This article reveals how citation networks can be used to understand and demonstrate the ways design serves to integrate other bodies of knowledge. Analysis focused on two corpuses of peer-reviewed journal articles, representing two bodies of knowledge. The first corpus consisted of 277 articles with the words “Design Thinking” in title. The second corpus contained 296 articles with the words “Network Science” in the title. Paper citation and document co-citation networks of individual and combined corpuses were analyzed. The overlap of paper citation networks was used to synthesize similarities, differences, and opportunities for further integration.
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- 2020
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76. Congregational health needs by key demographic variables: Findings from a congregational health needs assessment tool
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Brook E, Harmon, Emily Rose N, San Diego, Latrice C, Pichon, Terrinieka W, Powell, Fedoria, Rugless, Nathan T, West, Lottie, Minor, Sterling, McNeal, Lauren, McCann, Lauren S, Hales, Rachel, Davis, and Jonathan, Lewis
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Social Psychology ,Strategy and Management ,Geography, Planning and Development ,Public Health, Environmental and Occupational Health ,Middle Aged ,Overweight ,Stroke ,Hypertension ,Ethnicity ,Humans ,Obesity ,Business and International Management ,Needs Assessment ,Program Evaluation - Abstract
Health needs assessments identify important issues to be addressed and assist organizations in prioritizing resources. Using data from the Mid-South Congregational Health Survey, top health needs (physical, mental, social determinants of health) were identified, and differences in needs by key demographic variables (age, sex, race/ethnicity, education) were examined. Church leaders and members (N = 828) from 92 churches reported anxiety/depression (65 %), hypertension/stroke (65 %), stress (62 %), affordable healthcare (60 %), and overweight/obesity (58 %) as the top health needs in their congregations. Compared to individuals 55 years old and with a college degree, individuals ≥ 55 years old (OR
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- 2022
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77. The impact of the gut microbiota on human metabolism
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Jonathan Lewis Drake
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QM ,RA0421 ,QR - Abstract
The increasing prevalence of obesity is a global health problem due to the associations of obesity with co-morbidities such as diabetes, cancer and stroke. Current obesity management strategies and public health measures are doing little to fight the ever-growing burden of obesity in today’s obesogenic environment, therefore new approaches are clearly required. The gut microbiota has long been implicated in the pathophysiology of a number of diseases and is emerging as an important player in the pathogenesis of obesity, diabetes and metabolic syndrome, however the exact nature and mechanism behind how gut bacteria can influence host metabolism is an area of intense debate. This article explores how the gut bacteria can influence energy\ud metabolism and whether our knowledge of this can be converted into useful clinical interventions at a time when better care for obese and metabolically unhealthy patients\ud is fast becoming an urgent necessity.
- Published
- 2021
78. Mediterranean Connections: Representing the Migrant's Journey in Le voyage des âmes by Mounsi
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Jonathan Lewis
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- 2021
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79. Safeguarding Vulnerable Autonomy? Situational Vulnerability, The Inherent Jurisdiction and Insights from Feminist Philosophy
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Jonathan Lewis
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Vulnerable adult ,Liberty ,Informed Consent/legislation & jurisprudence ,media_common.quotation_subject ,Decision Making ,Vulnerability ,Medicine (miscellaneous) ,Safeguarding ,Feminist philosophy ,Situational vulnerability ,Feminism ,Vulnerable Populations ,Mental Competency/legislation & jurisprudence ,AcademicSubjects/LAW00490 ,Mental Competency ,Informed consent ,Situational ethics ,Autonomy ,media_common ,Informed Consent ,Jurisdiction ,Articles ,Inherent jurisdiction ,United Kingdom ,Personal Autonomy ,Normative ,Psychology ,Law ,Social psychology - Abstract
The High Court continues to exercise its inherent jurisdiction to make declarations about interventions into the lives of situationally vulnerable adults with mental capacity. In the light of the protective responses of health care providers and the courts to decision-making situations involving capacitous vulnerable adults, this article has two aims. The first is diagnostic. The second is normative. The first aim is to identify the harms to a capacitous vulnerable adult’s autonomy that arise based on the characterisation of situational vulnerability and autonomy as fundamentally opposed concepts or the failure to adequately acknowledge the conceptual relationship between them at common law. The second (normative) aim is to develop an account of self-authorised, intersubjective autonomy based on insights from analytic feminist philosophy. This approach not only attempts to capture the autonomy of capacitous vulnerable adults and account for the necessary harms to their autonomy that arise from standard common law responses to their situational vulnerability, it is also predicated on the distinctions between mental capacity, informed consent, and autonomy, meaning that it is better placed to fulfil the primary aim of the inherent jurisdiction—to facilitate the autonomy of vulnerable adults with capacity.
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- 2021
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80. Comparison of Buried Pipeline Crossing Assessments Using Api Rp 1102, Analytical Methods, and Finite Element Approach
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Pritha Ghosh, Nikhil Prakash Joshi, Jonathan Lewis Brewer, and Lawrence Matta
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Pipeline transport ,Computer science ,business.industry ,Finite element approach ,Pipeline (computing) ,Structural engineering ,business ,Finite element method - Abstract
API RP 1102 provides a method to calculate stresses in buried pipelines due to surface loads resulting from the encroachment of roads and railroads. The API RP 1102 approach is commonly used in the industry, and widely available software allows for quick and easy implementation. However, the approach has several limitations on when it can be used, one of which is that it is limited to pipelines crossing as near to 90° (perpendicular crossing) as practicable. In no case can the crossing be less than 30° . In this paper, the stresses in the buried pipeline under standard highway vehicular loading calculated using the API RP 1102 method are compared with the results of two other methods; an analytical method that accounts for longitudinal and circumferential through wall bending effects, and the finite element method. The benefit of the alternate analytical method is that it is not subject to the limitations of API RP 1102 on crossing alignment or depth. However, this method is still subject to the limitation that the pipeline is straight and at a uniform depth. The fact that it is analytical in nature allows for rapid assessment of a number of pipes and load configurations. The finite element analysis using a 3D soil box approach offers the greatest flexibility in that pipes with bends or appurtenances can be assessed. However, this approach is time consuming and difficult to apply to multiple loading scenarios. Pipeline crossings between 0° (parallel) and 90° (perpendicular) are evaluated in the assessment reported here, even though these are beyond the scope of API RP 1102. A comparison across the three methods will provide a means to evaluate the level of conservatism, if any, in the API RP 1102 calculation for crossing between 30° and 90° . It also provides a rationale to evaluate whether the API RP 1102 calculation can potentially be extended for 0° (parallel) crossings.
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- 2021
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81. Acknowledgments
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Jonathan Lewis
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- 2021
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82. Mobilization and stretching
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Jean-Pierre Pailloux, Jonathan Lewis, and Jean-Marie Denoix
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Mobilization ,Chemistry ,Biophysics - Published
- 2021
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83. General Points Concerning the Young Horse
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Jean-Marie Denoix, Jean-Pierre Pailloux, and Jonathan Lewis
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History ,Horse ,Genealogy - Published
- 2021
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84. Introduction
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Jean-Marie Denoix, Jean-Pierre Pailloux, and Jonathan Lewis
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- 2021
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85. Anatomy and basic biomechanical concepts
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Jean-Marie Denoix, Jean-Pierre Pailloux, and Jonathan Lewis
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Engineering ,business.industry ,Anatomy ,business - Published
- 2021
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86. Concepts of neuromuscular physiology
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Jean-Marie Denoix, Jean-Pierre Pailloux, and Jonathan Lewis
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business.industry ,Medicine ,business ,Neuroscience - Published
- 2021
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87. Preparing muscles for specific competition
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Jean-Pierre Pailloux, Jonathan Lewis, and Jean-Marie Denoix
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Competition (economics) ,Business ,Industrial organization - Published
- 2021
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88. Physical Therapy and Massage for the Horse
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Jean-Pierre Pailloux, Jonathan Lewis, and Jean-Marie Denoix
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medicine.medical_specialty ,Massage ,business.industry ,education ,Biomechanics ,Physical therapy ,Medicine ,business ,human activities ,health care economics and organizations - Abstract
The authors, a world leader in equine anatomy and imaging and a horse physiotherapist of international repute, provide a unique blend of basic biomechanics and practical physical therapeutic techniques, to relieve pain and improve performance, particularly in the sporting horse. This subtle and original book will be of interest to all those involved in equine welfare including veterinary practitioners, veterinary students, therapists, horse owners, riders, and trainers.
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- 2021
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89. Electrotherapy and Ultrasound
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Jean-Pierre Pailloux, Jonathan Lewis, and Jean-Marie Denoix
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business.industry ,Ultrasound ,Medicine ,Nuclear medicine ,business ,Electrotherapy (cosmetic) - Published
- 2021
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90. The techniques of massage
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Jean-Marie Denoix, Jean-Pierre Pailloux, and Jonathan Lewis
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medicine.medical_specialty ,Massage ,business.industry ,Physical therapy ,Medicine ,business - Published
- 2021
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91. Common lesions in joints, tendons and muscles
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Jean-Pierre Pailloux, Jonathan Lewis, and Jean-Marie Denoix
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- 2021
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92. Communication and relaxation
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Jean-Pierre Pailloux, Jonathan Lewis, and Jean-Marie Denoix
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Materials science ,Condensed matter physics ,Relaxation (physics) - Published
- 2021
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93. Treatment by anatomical area
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Jean-Marie Denoix, Jean-Pierre Pailloux, and Jonathan Lewis
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- 2021
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94. Changes in daily mental health service use and mortality at the commencement and lifting of COVID-19 ‘lockdown’ policy in 10 UK sites: a regression discontinuity in time design
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Philip Horner, David S. Baldwin, Neil Nixon, Caroline A. Jackson, Shanquan Chen, Ann John, Sabine Landau, Simon Douglas, Rachel Sokal, Andrew M. McIntosh, Tanya Smith, Paul Bibby, Ioannis Bakolis, Karthik Chinnasamy, David Osborn, Andrea Cipriani, Jonathan Lewis, Rudolf N. Cardinal, Shanaya Rathod, Dan W Joyce, Matthew Broadbent, Peter Phiri, Sze Chim Lee, Robert Stewart, Jane Beenstock, Robert M Waller, Stewart, Robert [0000-0002-4435-6397], Cardinal, Rudolf [0000-0002-8751-5167], Cipriani, Andrea [0000-0001-5179-8321], Jackson, Caroline A [0000-0002-2067-2811], John, Ann [0000-0002-5657-6995], McIntosh, Andrew [0000-0002-0198-4588], and Apollo - University of Cambridge Repository
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Mental Health Services ,Coronavirus disease 2019 (COVID-19) ,Adolescent ,Service delivery framework ,organisation of health services ,Mental health service ,03 medical and health sciences ,0302 clinical medicine ,old age psychiatry ,Medicine ,Humans ,030212 general & internal medicine ,Child ,Aged ,Inpatient care ,business.industry ,SARS-CoV-2 ,Outcome measures ,COVID-19 ,General Medicine ,Mental health ,United Kingdom ,030227 psychiatry ,Early intervention in psychosis ,Policy ,Communicable Disease Control ,Regression discontinuity design ,adult psychiatry ,business ,mental health ,Demography - Abstract
ObjectivesTo investigate changes in daily mental health (MH) service use and mortality in response to the introduction and the lifting of the COVID-19 ‘lockdown’ policy in Spring 2020.DesignA regression discontinuity in time (RDiT) analysis of daily service-level activity.Setting and participantsMental healthcare data were extracted from 10 UK providers.Outcome measuresDaily (weekly for one site) deaths from all causes, referrals and discharges, inpatient care (admissions, discharges, caseloads) and community services (face-to-face (f2f)/non-f2f contacts, caseloads): Adult, older adult and child/adolescent mental health; early intervention in psychosis; home treatment teams and liaison/Accident and Emergency (A&E). Data were extracted from 1 Jan 2019 to 31 May 2020 for all sites, supplemented to 31 July 2020 for four sites. Changes around the commencement and lifting of COVID-19 ‘lockdown’ policy (23 March and 10 May, respectively) were estimated using a RDiT design with a difference-in-difference approach generating incidence rate ratios (IRRs), meta-analysed across sites.ResultsPooled estimates for the lockdown transition showed increased daily deaths (IRR 2.31, 95% CI 1.86 to 2.87), reduced referrals (IRR 0.62, 95% CI 0.55 to 0.70) and reduced inpatient admissions (IRR 0.75, 95% CI 0.67 to 0.83) and caseloads (IRR 0.85, 95% CI 0.79 to 0.91) compared with the pre lockdown period. All community services saw shifts from f2f to non-f2f contacts, but varied in caseload changes. Lift of lockdown was associated with reduced deaths (IRR 0.42, 95% CI 0.27 to 0.66), increased referrals (IRR 1.36, 95% CI 1.15 to 1.60) and increased inpatient admissions (IRR 1.21, 95% CI 1.04 to 1.42) and caseloads (IRR 1.06, 95% CI 1.00 to 1.12) compared with the lockdown period. Site-wide activity, inpatient care and community services did not return to pre lockdown levels after lift of lockdown, while number of deaths did. Between-site heterogeneity most often indicated variation in size rather than direction of effect.ConclusionsMH service delivery underwent sizeable changes during the first national lockdown, with as-yet unknown and unevaluated consequences.
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- 2021
95. Rational Approach to Assess the Effect of Corrosion on Stiffened Panel Buckling and Ultimate Capacity
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Joshi, Nikhil Prakash, additional, Brewer, Jonathan Lewis, additional, and Rose, Christopher John, additional
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- 2021
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96. Radiation Therapy for Primary Cutaneous Gamma Delta Lymphoma Prior to Stem Cell Transplantation
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Sebastian Fernandez-Pol, Jonathan Lewis, Richard T. Hoppe, Bernice Y. Kwong, Susan M. Hiniker, Quaovi H. Sodji, Lawrie Skinner, Caressa Hui, Wen-Kai Weng, Noah Kastelowitz, Y. Wu, Michael S. Khodadoust, and Youn H. Kim
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Cancer Research ,medicine.medical_specialty ,Lung ,business.industry ,medicine.medical_treatment ,Abscopal effect ,General Medicine ,medicine.disease ,Lymphoma ,Transplantation ,Radiation therapy ,medicine.anatomical_structure ,Immune system ,Oncology ,medicine ,Radiology ,Bolus (digestion) ,Stem cell ,business - Abstract
We present a patient with widespread PCGD-TCL of the bilateral arms and legs, who underwent radiotherapy with 34 Gy in 17 fractions using circumferential VMAT and 3-D printed bolus to the 4 extremities prior to planned stem cell transplant, who was then found to have progression in the liver, lung, and skin, followed by drastic regression of all in and out-of-field lesions on imaging 1.5 months later. The cause of regression may be related to a radiation-induced abscopal effect from the immunomodulatory effects of radiation, or related to immune reactivation in the setting of cessation of systemic immunosuppressive agents.
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- 2021
97. Measurement of differential tt¯ production cross sections using top quarks at large transverse momenta in pp collisions at s=13 TeV
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Christopher Madrid, Emanuela Barberis, Avraham Yagil, Michael Dittmar, Steven Kaplan, Joona Havukainen, Aleksandar Aleksandrov, Jacob Linacre, Yongbin Feng, Bernard Ille, Dustin Anderson, Dinko Ferencek, Giovanni Franzoni, Evrim Ersin Kangal, Ashok Kumar, Hyonsan Seo, Rachael Bucci, Ismail Okan Atakisi, Eliza Melo Da Costa, Ravindra Kumar Verma, Hale Sert, Mario Pelliccioni, Anne Dabrowski, Bryan Caraway, Tulika Bose, Muriel Vander Donckt, M. Teklishyn, Giovanni Abbiendi, Valerie Scheurer, Amandeep Kaur Kalsi, Leonard Spiegel, Francesco Romeo, Robert Klanner, Andrea Benaglia, Darin Acosta, Kristian Allan Hahn, Daniele Bonacorsi, Nicholas Haubrich, Aleksandr Iuzhakov, Sándor Lökös, Kelci Mohrman, Jaebeom Park, Ricardo Lopez-Fernandez, Barbara Chazin Quero, Leszek Grzanka, Shimaa Abu Zeid, Svenja Schumann, Bodhitha Jayatilaka, Matthias Schnepf, Gillian Kopp, Daniel Rosenzweig, Jorge F de Trocóniz, Pedro José Fernández Manteca, Giuseppe Barbagli, Simone Pigazzini, Grigory Pivovarov, James Keaveney, Natasa Raicevic, Gianni Zumerle, Sunil Bansal, Emanuele Di Marco, Jean-Charles Fontaine, Anton Dimitrov, Werner Lustermann, Andromachi Tsirou, James Strait, Kinga Anna Wozniak, Stephen Sanders, Wesley H Smith, Neil Schroeder, Atanu Modak, Marco Cipriani, Peter Elmer, Gilson Correia Silva, Joseph Taylor, Yi Wang, Mikhail Dubinin, Wei Li, Suat Ozkorucuklu, Wei Xie, Rainer Wallny, Lizardo Valencia Palomo, Vladimir Cherepanov, Ivan Amos Cali, Hasan Ogul, K. Ellis, Ivan Atanasov, Aram Apyan, Norbert Neumeister, Yiwen Wen, Philip Baringer, Don Upul Jayasiri Sonnadara, Wim De Boer, Abhisek Datta, Tiziano Rovelli, Michal Bluj, George Stephans, Pritam Palit, Pietro Vischia, Dmitry Eliseev, Joao Seixas, Francisco Matorras, Camille Camen, John Perry Cumalat, Swagata Mukherjee, Valentin Sulimov, Philip H Butler, Toni Sculac, Tomasz Frueboes, Nicola De Filippis, Alberto Ruiz-Jimeno, Vladimir Rusinov, Kevin Black, Todor Ivanov, Hugo Becerril Gonzalez, Alessandro Di Mattia, Inkyu Park, Jarne De Clercq, Ibrahim Soner Zorbakir, Alexandra Carvalho Antunes De Oliveira, David Vannerom, Robert Cousins, Didar Dobur, Himal Acharya, Anna Macchiolo, Oliver Gutsche, Geng-Yuan Jeng, Giuseppe Iaselli, Kadir Ocalan, Joachim Baechler, Georgi Sultanov, Armando Bermúdez Martínez, Evan Wolfe, Austin Ball, David Cutts, Gian Luca Pinna Angioni, Kevin Stenson, Vladimir Blinov, Nathaniel Odell, Achim Stahl, Juan Suarez Gonzalez, M. Mohammadi Najafabadi, Charles Harrington, Emil Sørensen Bols, Panja-Riina Luukka, Douglas Burns, Andreas Pfeiffer, Alessandra Cappati, Roberto Salerno, Vladimir Makarenko, Luc Pape, William Arthur Nash, Vassili Kachanov, Jeffrey Richman, Gilvan Alves, Berkan Kaynak, Patrick Jarry, Benjamin Charles Radburn-Smith, David Petyt, Uttiya Sarkar, Kevin Nash, Moritz Guthoff, Marc Weber, Reham Aly, Gourab Saha, Valentina Dutta, Ram Krishna Dewanjee, Bora Isildak, Jan Kaspar, Hans Rykaczewski, Chiara Mariotti, Houmani El Mamouni, Marco Monteno, Ohannes Kamer Köseyan, Natale Demaria, Angelo Giacomo Zecchinelli, Hyunyong Kim, Vukasin Milosevic, Sarah Malik, Nikkie Deelen, Radia Redjimi, Kirill Skovpen, Alessio Boletti, Jie Zhang, Andres Mateus Vargas Hernandez, Francesca Romana Cavallo, Viktor Savrin, Mitchell Wayne, Karol Bunkowski, Angela Giraldi, Daniel Winterbottom, Oz Amram, Prakash Thapa, Olmo Cerri, Olivier Davignon, Dmitri Konstantinov, Andreas Psallidas, Douglas Wright, Giacomo Fedi, Anup Kumar Sikdar, Luis Junior Sanchez Rosas, Konstantin Androsov, Tai Sakuma, Simone Scarfi, Sandeep Kaur, Tanvi Wamorkar, Eshwen Bhal, Giorgio Maggi, Sadia Khalil, Stefan Grünendahl, Jochen Schieck, Thorben Quast, Benjamin Krikler, Francisco Yumiceva, Ritva Kinnunen, Petar Maksimovic, Patrick Janot, Jan Tomsa, Joosep Pata, Colin Bernet, Amedeo Staiano, Gabriel Madigan, Anterpreet Kaur, Alexey Volkov, Yutaro Iiyama, Tommaso Diotalevi, Panagiotis Katsoulis, Philip Harris, Noemi Beni, Olivér Surányi, Thorsten Chwalek, Christopher Cosby, Nadia Pastrone, Ugur Kiminsu, Pieter David, Po-Hsun Chen, Stefano Mersi, Maria Isabel Josa, Shashikant Dugad, Manfred Paulini, Eva Halkiadakis, Olena Karacheban, Navid Rad, Mate Csanad, Stephen Mrenna, Denys Lontkovskyi, Konstantinos Manolopoulos, Intae Yu, Jing Wang, Priyanka Priyanka, Olga Evdokimov, Junghwan Goh, Livio Fanò, Alessandro Da Rold, Fatma Boran, Martti Raidal, Elena Voevodina, Lara Zygala, Nicola Turini, Cristina Mantilla, Pierluigi Bortignon, Irene Bachiller, Ioannis Papakrivopoulos, Daniel Marley, Laurent Thomas, Raffaella Tramontano, Mark Derdzinski, Ketino Kaadze, Frank Glege, Cristina Biino, Luigi Benussi, Tatyana Dimova, Andrea Perrotta, Ugo Gasparini, Veikko Karimäki, Nicola Cavallo, Sara Fiorendi, Matti J Kortelainen, Daniele Pedrini, Benedikt Maier, Cheng-Chieh Peng, Ivan Mikulec, Francesco Micheli, Gul Gokbulut, Anna Elliott-Peisert, Vuko Brigljevic, Victor Murzin, David Taylor, Josry Metwally, Aran Garcia-Bellido, Alexander Titterton, Eric Appelt, Savvas Kyriacou, Debarati Roy, Marc Weinberg, Gouranga Kole, Bruno Galinhas, Marco Zanetti, Frank Jensen, Fuqiang Wang, Justin Pilot, Petr Moisenz, Burin Asavapibhop, Anadi Canepa, Xunwu Zuo, Katja Klein, Jens Multhaup, David Ja Cockerill, Wolfgang Lange, Gianni Masetti, Erik Gottschalk, Andrea Delgado, Duncan Leggat, Mehdi Rahmani, Shilpi Jain, Fan Xia, Dietrich Liko, Mykhailo Dalchenko, Tamás Álmos Vámi, Camilo Andrés Salazar González, Vasken Hagopian, Amitabh Lath, Simon Kudella, Christine Mclean, Shirin Chenarani, Denis Rathjens, Alexandre Zabi, Werner Sun, Nicholas Smith, James Bueghly, Matthew Nguyen, Mohammed Mahmoud, Tae Jeong Kim, Nicolaus Kratochwil, Ravi Janjam, Siddharth Narayanan, Anton Karneyeu, Leonard Apanasevich, Wolfgang Funk, Sungwoong Cho, Catherine Adloff, Henning Keller, James Hirschauer, Nimantha Perera, Bhargav Madhusudan Joshi, Georgios Krintiras, Matteo Presilla, Ivan Ovtin, Furkan Dolek, Ulascan Sarica, Franco Ligabue, Zeynep Demiragli, Marina Kolosova, Yalcin Guler, Jozsef Molnar, Barbara Alvarez Gonzalez, Stefan A. Maier, Costas Foudas, Devdatta Majumder, Anna Zacharopoulou, Giorgio Apollinari, Valerio Re, Andrea Carlo Marini, Marino Missiroli, Amandeep Kaur, Andrius Juodagalvis, Inna Makarenko, Victor Shang, Santeri Laurila, Christian Dziwok, Samuel Webb, Emmanouil Vourliotis, Markus Radziej, Roberto Mulargia, Pedro G Mercadante, Michael Murray, Jakob Salfeld-Nebgen, Louis Moureaux, Dylan Gilbert, Sebastian Wiedenbeck, Kunal Kothekar, Kousik Naskar, Jingyu Luo, Prafulla Kumar Behera, Saikat Karmakar, Diego Matos Figueiredo, Roger Wolf, Marina Chadeeva, Yongsun Kim, Lev Dudko, Jeremy Andrea, Christopher Brainerd, Sijing Zhang, Weinan Si, Matteo Maria Defranchis, Alessandro Braghieri, Nicola Minafra, Johannes Schulz, Benjamin Mesic, Kyeongpil Lee, Emmanuel Olaiya, Alexander Schmidt, Nadir Daci, Kerstin Borras, Diana Seitova, Teruki Kamon, Hans-Christian Kaestli, Duong Nguyen, Alexander Tapper, Dario Soldi, Vyacheslav Krutelyov, Dominique Gigi, Simona Cometti, Jin Wang, Dalath Rachitha Mendis, Deborah Pinna, Riccardo Andrea Manzoni, Adriano Di Florio, Christian Veelken, Gyorgy Bencze, Michael Krohn, Jeremie Alexandre Merlin, Piotr Zalewski, Redwan Habibullah, Hong Ni, Roger Rusack, Marc Dejardin, Raffaello D'Alessandro, Slawek Tkaczyk, Tielige Mengke, Mykola Savitskyi, Valeria Botta, Mohsen Khakzad, Andre David Tinoco Mendes, Liliana Teodorescu, Michele Bianco, Francesco Moscatelli, Adolf Bornheim, A. Álvarez Fernández, Kun Shi, Antonio Cassese, Maxim Pieters, Ulrich Heintz, Robert M Harris, Xinmei Niu, Bjorn Burkle, Elliot Hughes, Gurpreet Singh Chahal, Vitaly Smirnov, Nazar Bartosik, Enrique Palencia Cortezon, Jonathan Lewis, Andrew Buccilli, Charles C. Richardson, Dragos Velicanu, Qamar Hassan, Nuno Leonardo, Markus Klute, Markus Stoye, Kai Yi, Tatjana Susa, Dimitri Bourilkov, Andrew Whitbeck, Viktor Veszpremi, Joel Goldstein, Federico Siviero, George Wei-Shu Hou, Nan Lu, Garrett Funk, Helena Bialkowska, Jack King, Hanwen Wang, Luca Guzzi, Raghunath Pradhan, Andrei Sobol, Irene Dutta, Kin Ho Lo, Gabriella Pasztor, Sebastian Templ, Antonio María Pérez-Calero Yzquierdo, Daniel Gonzalez, Pierluigi Zotto, Roberto Dell'Orso, Sergey Troshin, Cecilia Elena Gerber, Aaron Bundock, Katerina Lipka, Martin Kirakosyan, Marius Teroerde, Vladimir Popov, Otman Charaf, Javier Duarte, Peter Robmann, Tiziano Camporesi, L. Brigliadori, Pierluigi Paolucci, Marc Huwiler, Daniele Spiga, Ashutosh Bhardwaj, Michael Finger Jr, Laurent Pétré, Brent Stone, Seema Sharma, Srinidhi Bheesette, Piotr Traczyk, Aliaksandr Litomin, Oliver Rieger, Kevin Flöh, Charalambos Nicolaou, Georgia Karapostoli, Andrea Cardini, Shabnam Jabeen, Luciano Ristori, Milena Misheva, Luigi Calligaris, Max Philip Rauch, Marvin Johnson, Kevin Pedro, Tiehui Liu, Paraskevas Gianneios, Oliver Pooth, Sergey Guts, Silvano Tosi, Robert Bainbridge, Yuan Chen, Guillaume Bourgatte, Erhan Gülmez, Kaori Maeshima, Aurelijus Rinkevicius, Gobinda Majumder, David D'Enterria, Georgios Bakas, Clément Leloup, Hui Wang, Sheila Mara Silva Do Amaral, Lata Panwar, Peter Raics, Peicho Petkov, Sicheng Wang, Alexander Nikitenko, Florian Joel J Bury, Thomas Reitenspiess, Alain Hervé, Yuri Skovpen, Niki Saoulidou, Zhengcheng Tao, Kevin Mcdermott, Dmytro Kovalskyi, Sercan Sen, Gyorgy Vesztergombi, Ali Harb, Kenneth Long, Luca Malgeri, Andre Govinda Stahl Leiton, Louise Skinnari, Vito Palladino, Nural Akchurin, Hannu Siikonen, Edoardo Bossini, Ryan Heller, Daniel Treille, Ivan Vila, Jan Steggemann, Andrés Cabrera, Marco Bozzo, Kelvin Mei, Gui Nyun Kim, Tariq Aziz, Dave M Newbold, Stefano Ragazzi, Jane Nachtman, Mateo Ramírez García, Sergio F Novaes, Samet Lezki, Daniel Savoiu, D. De Jesus Damiao, Marta Verweij, Morgan Lethuillier, Yasar Onel, Catherine Vander Velde, Helio Nogima, Davide Valsecchi, Zuhal Seyma Demiroglu, C. A. Carrillo Montoya, Silvia Goy Lopez, Zoltan Gecse, Felipe Ramirez, Fanbo Meng, Jhovanny Mejia Guisao, Caroline Collard, Frank Jm Geurts, Claudio Caputo, Arnaud Steen, H. S. Chen, Martin Erdmann, Andrew Wisecarver, Patricia McBride, Krzysztof Doroba, Pantelis Kontaxakis, Dylan Rankin, Andrew Brinkerhoff, Thomas Ferguson, Leonardo Cristella, Marko Dragicevic, Suman Chatterjee, Aurélien Carle, Erik Brücken, Achille Petrilli, Chun-Hua Jiang, Sushil Chauhan, Kajari Mazumdar, Nickolas Mccoll, Deniz Sunar Cerci, Laszlo Gutay, Hao Qiu, Sebastian Wuchterl, Dipak Kumar Mishra, Simone Bologna, Muhammad Imran Malik Awan, Tamas Novak, D. Domínguez Damiani, Diego Beghin, Andrej Saibel, Oleg Teryaev, Izzeddin Suat Donertas, Livia Soffi, Christopher Seez, Andrea García Alonso, Ada Solano, Willard Johns, Seema Bahinipati, Monika Bharti, Miguel Medina Jaime, George Karathanasis, Gaetano-Marco Dallavalle, Brandon Allen, Martina Malberti, Jay Dittmann, Daniel Tapia Takaki, Pawan Kumar Netrakanti, Elif Asli Yetkin, Evgueni Tcherniaev, Vitalii Okhotnikov, Petar Adzic, Philip Chang, Elisabetta Gallo, Vincenzo Ciriolo, Boaz Klima, Richard G Kellogg, Michael Tytgat, Tomas Lindén, Alice Florent, Pallabi Das, Georg Steinbrück, Georgios Anagnostou, Melody A. Swartz, Maxwell Chertok, Danek Kotlinski, Jordan Martins, Denis Gelé, Chang-Seong Moon, Genady Gavrilov, Catherine Schiber, Mauro Emanuele Dinardo, Carmen Albajar, Claudia Pistone, Wolfgang Adam, Prabhat Ranjan Pujahari, Urs Langenegger, Jose F Benitez, Samuel Higginbotham, Jose Flix, Alberto Sánchez Hernández, Pasquale Musella, Sangeun Lee, Salvatore Costa, Alberto Orso Maria Iorio, Felice Pantaleo, Chanwook Hwang, Yangyang Cheng, Indara Suarez, Andrea Bocci, Jasvinder A. 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Butler, Fabiola Vazquez Valencia, Renato Potenza, Guenter Eckerlin, Demetra Tsiakkouri, Shawn Zaleski, Paolo Lariccia, Dmitry Sosnov, Rudolf Fruehwirth, Siarhei Shulha, Mayda Velasco, Grace Cummings, Vladimir Ivantchenko, M. Melo De Almeida, Dipika Dash, Rishi Patel, Juan Pablo Fernández Ramos, Paolo Gunnellini, Nelson Vanegas Arbelaez, Armen Tumasyan, Paula Eerola, Juliet Ritchie Patterson, Manoj Sharan, Nick Van Remortel, Chad Freer, Stefan Piperov, Mohit Gola, Maria Spiropulu, James M. Buchanan, Samila Muthumuni, Joao Varela, Bipen Singh, Leander Litov, Jean-Pierre Merlo, Zhicai Zhang, Rocky Bala Garg, Kithsiri Malagalage, Roy Montalvo, Sandra Consuegra Rodríguez, Simon Christoph Schuler, János Karancsi, Rui Xiao, Kevin Burkett, Joanne Cole, Eija Tuominen, Luigi Fiore, Patrick Connor, Roberval Walsh, Zheng Wang, Wajid Ali Khan, Inna Kucher, Jelena Mijuskovic, Anna Teresa Meneguzzo, Joern Schwandt, Christopher Mcginn, Daniel Robert Marlow, Thea Klaeboe Aarrestad, Christian Dorfer, Matthew Herndon, Elisa Fontanesi, Vasilije Perovic, Thomas James, Sevgi Tekten, Jithin Madhusudanan Sreekala, Giovanna Selvaggi, Daniel Abercrombie, Gabor Istvan Veres, Fabio Cossutti, Sarah Catherine Eno, Jan-Frederik Schulte, Yen-Jie Lee, Sabino Meola, Roberto Covarelli, Sergio Cittolin, Jared Sturdy, Yves Sirois, Vladislav Borchsh, Pieter Everaerts, Titas Roy, Pablo De Castro Manzano, Doga Gulhan, Louis Lyons, Federica Legger, Tuure Tuuva, Margaret Zientek, Ozgun Kara, Jovan Milosevic, Mareike Meyer, Ramkrishna Sharma, Kaya Tatar, Sandra S. Padula, Paolo Vitulo, William J Spalding, Alexx Perloff, Roman Ryutin, Federica Primavera, Roberto Carlin, Pierre Depasse, Vyacheslav Klyukhin, Victor Golovtcov, Jaana Kristiina Heikkilä, Hugues Lattaud, Daniel Gastler, Vitaliano Ciulli, Apostolos Panagiotou, Benjamin Kilminster, Hyun-Soo Kim, Benjamin Fischer, Bingran Wang, Jay Roberts, Christopher West, Jonas Roemer, Alain Givernaud, Seth Moortgat, Stefano Bianco, Brandon Chiarito, Sarah Freed, Alicia Calderon, Seyed Mohsen Etesami, Sandra Oliveros, Mauro Donegà, Igor Bayshev, Alfredo Gurrola, Ufuk Guney Tok, Christopher Brew, Diogo Bastos, Gintautas Tamulaitis, Lothar At Bauerdick, Jason Sang Hun Lee, Yury Ivanov, Lorenzo Viliani, Abhishikth Mallampalli, Si-Jin Qian, Isabel Ojalvo, Muhammad Waqas, Izaak Neutelings, Predrag Milenovic, Peter R Hobson, Yajun Mao, Andre Sznajder, Leonardo Giannini, Serdal Damarseckin, Maria Giulia Ratti, Mikhail Kirsanov, Youn Roh, Barry Blumenfeld, Yuri Gershtein, Prasant Kumar Rout, Riccardo Paramatti, Andrea Giammanco, Priyanka Kumari, Daniel Diaz, Sudarshan Paramesvaran, Victor Daniel Elvira, Bilal Kiani, Stephane Cooperstein, Varun Sharma, Biagio Rossi, Emmanuelle Perez, Alberto Escalante Del Valle, John Strologas, Charles Maguire, Theodoros Geralis, Andrea Rizzi, Amal Sarkar, Cristina Riccardi, W. A. T. Wan Abdullah, Deshitha Chamikara Wickramarathna Dhammage, Natalia Emriskova, Jamal Rorie, Jason Gilmore, Marco Paganoni, Don Lincoln, Andrew Beretvas, Otto Hindrichs, Clemens Wöhrmann, Li Yuan, Yeonju Go, Aashaq Shah, Christophe Ochando, Jory Sonneveld, Hafeez R Hoorani, Francesco Santanastasio, Stoyan Stoynev, Tongguang Cheng, Sergo Jindariani, Daniel John Karmgard, Manfred Jeitler, Fabrizio Palla, Andrew Melo, Owen Baron, Mengyao Shi, Bruno Lenzi, Wenyu Zhang, Caleb Smith, Florian Michael Pitters, Steve Schnetzer, Saranya Ghosh, Klaas Padeken, Renato Campanini, Rino Castaldi, John Hakala, Gautier Hamel de Monchenault, Roland Koppenhöfer, Melissa Quinnan, Stephanie Kwan, Alexander Bylinkin, T. Tabarelli de Fatis, Andrew Hart, Demetrios Loukas, Kalpanie Liyanage, Jan Kieseler, Laurent Forthomme, Giulia Negro, Daniel Teyssier, Leonid Kardapoltsev, Victor Perelygin, Manisha Lohan, Joscha Knolle, Jordan Nash, Sung Keun Park, Carlos Lourenco, Annapaola De Cosa, Drew Baden, Alessandra Fanfani, Andrew Askew, Nicholas Menendez, Styliani Orfanelli, Robert Schöfbeck, Miao Hu, Bugra Bilin, Candan Isik, Kati Lassila-Perini, Luca Perrozzi, Kevin Sung, Konstanty Sumorok, Zukhaimira Zolkapli, Petra Merkel, De Hua Zhu, Vyacheslav Valuev, Rachel Yohay, F. Simonetto, Si Xie, Ren-Yuan Zhu, Robert Stone, Sergio P Ratti, Frank Chlebana, Kuntal Mondal, Giovanni Organtini, Metin Yalvac, Stephan Lammel, Tagir Aushev, Pascal Vanlaer, Richard Breedon, Hugo Delannoy, Daniel Noonan, Simone Calzaferri, Olaf Behnke, Alessia Saggio, Andreas Bernhard Meyer, Yang Yang, Aliakbar Ebrahimi, Markus Spanring, Kyong Sei Lee, Erik Butz, Alexei Raspereza, Christoph Heidecker, Evgueni Vlasov, Alessandro Calandri, Karl Ehataht, Qianying Guo, Paolo Spagnolo, Claudio Quaranta, Lindsey Gray, Souvik Das, Enrico Robutti, Kurtis F Johnson, Bayram Tali, Merijn Van De Klundert, Greg P Heath, Alexey Kalinin, Maxime Gouzevitch, Márton Bartók, Salvatore Nuzzo, Philippe Bloch, Martina Vit, Andrea Beschi, Ewerton Belchior Batista Das Chagas, Marek Niedziela, Christoph Schäfer, Derek James Cranshaw, Alberto Belloni, Jan Eysermans, Arun Kumar, Haneol Lee, Alexander Grohsjean, Dimitrios Tsitsonis, Lorenzo Bianchini, Benjamin Bordy Tannenwald, Maksym Titov, Daniel Klein, Lev Uvarov, Rajdeep Mohan Chatterjee, Natalia Lychkovskaya, Attilio Santocchia, Jean Fay, Dennis Roy, Igor Dremin, Abideh Jafari, Rogelio Reyes-Almanza, Federico Ferri, Ahmed Ali Abdelalim, Douglas Berry, Igor Azhgirey, Frank Golf, Radek Zlebcik, Timo Peltola, Debabrata Bhowmik, Conor Henderson, Christina Snyder, Burak Bilki, Nicolò Trevisani, Konstantin Matchev, Jean-Marie Brom, Michael Schmitt, Carlo Rovelli, Silvio Donato, Xavier Coubez, Shih-Chang Lee, Fabrice Couderc, Dirk Krücker, Gianluca Cerminara, Lorenzo Russo, Jesus Manuel Vizan Garcia, Egidio Longo, Francesca Ricci-Tam, Federico De Guio, Ivan Marchesini, Harry Cheung, Mohsan Waseem Ather, Anna Stakia, Peter Schleper, Zhen Hu, Keith Ulmer, Sébastien Wertz, Vishwajeet Jha, Salvatore Rappoccio, Loukas Gouskos, Senne Van Putte, Maksim Azarkin, Ota Kukral, Zoltan Laszlo Trocsanyi, D. Del Re, Antonio Vilela Pereira, Dong Hee Kim, Xavier Janssen, Ken W Bell, Vincent Lemaitre, Shane Breeze, Iban Jose Cabrillo, Davide Fiorina, Paul Baillon, Muhammad Irfan Asghar, Artur Apresyan, Marc Besancon, Dinyar Rabady, Wolfram Dietrich Zeuner, Gian Piero Siroli, Malgorzata Kazana, Hyejin Kwon, Mauro De Palma, Menglei Sun, Jeremy Mans, Gage Dezoort, Konstantinos Theofilatos, Sandor Czellar, Manuel Giffels, Pavel Bunin, Gustavo Gil Da Silveira, Maria Rosaria Di Domenico, Guo-Ming Chen, Arabella Martelli, Soureek Mitra, Muhammad Ahmad, Suman Bala Beri, Nur Zulaiha Jomhari, Vivian O'Dell, Juliette Alimena, Paul Asmuss, Miroslav Bonchev, Ernesto Migliore, Hans-Jürgen Simonis, Todd Adams, Andrew Wightman, Dennis Schwarz, Ekaterina Kuznetsova, Lloyd Stanley Durkin, Hevjin Yarar, Wit Busza, Vincenzo Innocente, Mattia Lizzo, Ioannis Papadopoulos, Unki Yang, David Seith, Erica Brondolin, Yonghoon Lee, Dhanush Anil Hangal, Geng Chen, Paul Schütze, and Giovanni Petrucciani
- Subjects
Physics ,Quark ,Top quark ,Particle physics ,Muon ,Large Hadron Collider ,010308 nuclear & particles physics ,High Energy Physics::Phenomenology ,Parton ,Jet (particle physics) ,01 natural sciences ,Bottom quark ,0103 physical sciences ,High Energy Physics::Experiment ,Neutrino ,010306 general physics - Abstract
A measurement is reported of differential top quark pair (tt¯) production cross sections, where top quarks are produced at large transverse momenta. The data collected with the CMS detector at the LHC are from pp collisions at a center-of-mass energy of 13 TeV corresponding to an integrated luminosity of 35.9 fb-1. The measurement uses events where at least one top quark decays as t→Wb→qq¯′b and is reconstructed as a large-radius jet with transverse momentum in excess of 400 GeV. The second top quark is required to decay either in a similar way or leptonically, as inferred from a reconstructed electron or muon, a bottom quark jet, and missing transverse momentum due to the undetected neutrino. The cross section is extracted as a function of kinematic variables of individual top quarks or of the tt¯ system. The results are presented at the particle level, within a region of phase space close to that of the experimental acceptance, and at the parton level and are compared to various theoretical models. In both decay channels, the observed absolute cross sections are significantly lower than the predictions from theory, while the normalized differential measurements are well described.
- Published
- 2021
- Full Text
- View/download PDF
98. An in vitro 3D self-structuring bone model capable of long-term osteocyte culture
- Author
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Melissa Finlay, Laurence Hill, Miruna Chipara, Erik Hughes, Jonathan Lewis, Georgiana Neag, Kieran Patrick, James Edwards, Liam Grover, and Amy Naylor
- Subjects
Endocrinology, Diabetes and Metabolism ,Orthopedics and Sports Medicine - Published
- 2022
- Full Text
- View/download PDF
99. Colonial Continuities and Decoloniality in the French-Speaking World : From Nostalgia to Resistance
- Author
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Sarah Arens, Nicola Frith, Jonathan Lewis, Rebekah Vince, Sarah Arens, Nicola Frith, Jonathan Lewis, and Rebekah Vince
- Subjects
- Decolonization--French-speaking countries
- Abstract
This volume pays tribute to the work of Professor Kate Marsh (1974-2019), an outstanding scholar whose research covered an extraordinarily wide range of interests and approaches, encompassing the history of empire, literature, politics and cultural production across the Francophone world from the eighteenth to the twenty-first century. Each of the chapters within engages with a different aspect of Marsh's interest in French colonialism and the entanglements of its complex afterlives — whether it be her interest in the longevity of imperial rivalries; loss and colonial nostalgia; exoticism and the female body; decolonization and the ends of empire; the French colonial imagination; the policing of racialized bodies; or anti-colonial activism and resistance. As well as reflecting the geographical and intellectual breadth of Marsh's research, the volume demonstrates how her work continues to resonate with emerging scholarship around decoloniality, transcolonial mobilities and anti-colonial resistance in the Francophone world. From French India to Algeria and from the Caribbean to contemporary France, this collection demonstrates the persistent relevance of Marsh's scholarship to the histories and legacies of empire, while opening up conversations about its implications for decolonial approaches to imperial histories and the future of Francophone Postcolonial Studies.
- Published
- 2023
100. Terrorism in France: Real Threats, National Fight, and International Cooperation
- Author
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Jonathan Lewis and Valentina Shiyan
- Subjects
Political science ,Political economy ,Field (Bourdieu) ,Terrorism ,Legislation ,Asymmetric warfare ,Institutional structure ,Counter terrorism ,Review analysis ,Key features - Abstract
The article analyzes the system of countering terrorism in France, including taking into account its institutional structure. The authors give a legal assessment of international terrorism as a crime and highlight the key features of French legislation in the field of prevention of terrorist threats. A review analysis of the profile counter-terrorism units of France was carried out.
- Published
- 2021
- Full Text
- View/download PDF
Catalog
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