94 results on '"Jinguang Li"'
Search Results
52. Characterization of the Widmanstätten structure in γ-TiAl alloy using an EBSD-FIB-TEM combined process
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Zitong Gao, Rui Hu, Xiangyu Gao, Yulun Wu, Hang Zou, Jinguang Li, and Mi Zhou
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Mechanics of Materials ,Mechanical Engineering ,Metals and Alloys ,General Materials Science ,Condensed Matter Physics - Published
- 2023
53. Differences in Cortical Thickness in Schizophrenia Patients With and Without Auditory Verbal Hallucinations
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Honghong Ren, Qianjin Wang, Chunwang Li, Zongchang Li, Jinguang Li, Lulin Dai, Min Dong, Jun Zhou, Jingqi He, Yanhui Liao, Ying He, Xiaogang Chen, and Jinsong Tang
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Cellular and Molecular Neuroscience ,Molecular Biology - Abstract
Auditory verbal hallucinations (AVHs) are one of the most common and severe symptoms of schizophrenia (SCZ), but the neuroanatomical mechanisms underlying AVHs remain unclear. This study aimed to investigate whether persistent AVHs (pAVH) are associated with cortical thinning of certain brain regions in patients with SCZ. With the use of the 3T magnetic resonance imaging (MRI) technology, we acquired and analyzed data from 79 SCZ patients with pAVH (pAVH group), 60 SCZ patients without AVHs (non-AVH group), and 83 healthy controls (HC group). The severity of pAVH was assessed by the P3 hallucination items in the Positive and Negative Syndrome Scale (PANSS) and the Auditory Hallucinations Rating Scale (AHRS). Cortical thickness analysis was used to compare the region of interest (ROI) cortical thickness between the groups. The relationship between the severity of pAVH and cortical thickness was also explored. Compared with the non-AVH and HC groups, the pAVH group exhibited significantly reduced cortical thickness in the bilateral lateral orbitofrontal region (p < 0.0007, after Bonferroni correction); no significant difference was found between the non-AVH group and the HC group. The cortical thickness of the left lateral orbitofrontal cortex (P3: r = −0.44, p < 0.001; AHRS: r = −0.45, p < 0.001) and the right lateral orbitofrontal cortex (P3: r = −0.36, p = 0.002; AHRS: r = −0.33, p = 0.004) were negatively correlated with the severity of pAVH (after Bonferroni correction, p < 0.0125). Therefore, abnormal thickness of the bilateral lateral orbitofrontal cortices might be associated with pAVHs in SCZ patients.
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- 2021
54. Investigation of interfacial thermal stabilities of Nbf/TiAl composites with and without Al2O3 coating in interface
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Mi Zhou, Rui Hu, Jinguang Li, Hang Zou, Zitong Gao, and Xian Luo
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General Physics and Astronomy ,Surfaces and Interfaces ,General Chemistry ,Condensed Matter Physics ,Surfaces, Coatings and Films - Published
- 2022
55. First-principles investigation on electronic structures and energetic characteristics of γ/γ tilt grain boundaries in γ-TiAl intermetallic
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Zitong Gao, Rui Hu, Dawei Xiao, Jinhan Xu, Jinguang Li, and Mi Zhou
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Mechanics of Materials ,Mechanical Engineering ,Materials Chemistry ,Metals and Alloys ,General Chemistry - Published
- 2022
56. Predictive method for the macroscopic mechanical properties of concrete at ultra-low temperatures
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Yuanqi Cai, Yue Zhang, Yang Liu, and Jinguang Li
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General Materials Science ,Building and Construction ,Civil and Structural Engineering - Published
- 2022
57. Cycle-resolved visualization of lubricant-induced abnormal combustion in an optical natural gas/hydrogen engine
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Lin Chen, Xiao Zhang, Ren Zhang, Jinguang Li, Jiaying Pan, and Haiqiao Wei
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Fuel Technology ,General Chemical Engineering ,Organic Chemistry ,Energy Engineering and Power Technology - Published
- 2022
58. Preparation of Al2O3 coating on Nb fiber and the effect on interfacial microstructure of Nbf/TiAl composite
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Mi Zhou, Rui Hu, Jinguang Li, Yanni Tan, Xiangyu Gao, and Xian Luo
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science ,Condensed Matter Physics - Published
- 2022
59. Experimental and theoretical internal forced convection investigation on air pipe cooling of large-dimension RC walls
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Jinguang Li, Geng Yan, Yanjie Song, Suduo Xue, and Li Xiongyan
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Air cooling ,Materials science ,0211 other engineering and technologies ,020101 civil engineering ,02 engineering and technology ,Building and Construction ,Heat transfer coefficient ,Mechanics ,Finite element method ,0201 civil engineering ,Forced convection ,Cracking ,021105 building & construction ,Thermal ,Coupling (piping) ,General Materials Science ,Thermal analysis ,Civil and Structural Engineering - Abstract
Air pipe cooling is an emerging technique in dealing with the hydration heat and thermal induced cracking of massive concrete structures. In order to investigate the influence of air pipe cooling on temperature distribution in large-dimension concrete walls, in situ experiments of heat transfer coefficient for internal forced convection were conducted on one experimental wall of 3.6 m × 3.6 m × 0.8 m in dimension with properly embedded corrugated pipes. The relationship between average inlet air velocity and average heat transfer coefficient for internal forced convection was then obtained and fitted to a proposed formula. In addition, air cooling experiments were performed on another three experimental walls to monitor the temperature variations of internal concrete. Meanwhile, finite element (FE) thermal analysis with the proposed formula was carried out and compared with the results of air cooling experiments to verify the accuracy of the proposed FE method. As the comparison results show, the calculated temperature curves are in good agreement with the tested data, with an average deviation of 0.07 °C, 0.13 °C and 0.19 °C under average inlet velocity u ¯ in of 3.78 m/s, 8.12 m/s and 11.64 m/s, respectively. It indicates that the FE analysis with the proposed heat transfer coefficient formula for internal forced convection is effective in estimating concrete temperature variations, providing a reliable fundamental approach for further thermo-mechanical coupling analysis and ventilation design in practical engineering projects.
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- 2019
60. High temperature micro-deformation behavior of continuous TiNb fiber reinforced TiAl matrix composite investigated by in-situ high-energy X-ray diffraction
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Jinguang Li, Rui Hu, Mi Zhou, Zitong Gao, Yulun Wu, and Xian Luo
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science ,Condensed Matter Physics - Published
- 2022
61. Metastable transformation behavior in a Ta-containing TiAl-Nb alloy during continuous cooling
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Zitong Gao, Rui Hu, Zijing Huang, Yulun Wu, Jinguang Li, and Mi Zhou
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Mechanics of Materials ,Mechanical Engineering ,Materials Chemistry ,Metals and Alloys - Published
- 2022
62. UHVDC transmission line diagnosis method for integrated community energy system based on wavelet analysis
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Tianlong Yuan, Jinguang Liang, Xiaofei Zhang, Kaijie Liang, Lingzi Feng, and Zhaofu Dong
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integrated community energy system ,wavelet analysis ,UHVDC power transmission ,singular spectrum entropy ,support vector machines ,characteristic vector ,General Works - Abstract
With the large-scale development of renewable energy power, China has faced with the challenges of the reverse regional distribution of wind and solar resources and power load, as well as the intermittency and randomness of renewable energy power. Therefore, China is vigorously developing ultra-high voltage direct current (UHVDC) transmission technology to solve the problem of insufficient flexibility caused by the uncertainty of renewable energy and the fluctuation of multi-energy loads in integrated community energy systems. UHVDC plays an increasingly pivotal role in the west-east transmission system in China’s power system due to its high transmission capacity and long transmission distance. Once the fault occurs in the ultra-high voltage direct (UHVD) transmission line, quick and accurate fault location identification is of great significance. Hence, this paper proposes a UHVDC transmission line diagnosis method based on wavelet analysis for integrated community energy systems. Wavelet transform (WT) is used to decompose the transient signal on a multi-scale, and then power systems computer-aided design (PSCAD) software is utilized for simulation calculation to obtain the singular spectrum entropy of each layer and facilitate wavelet transformations for signal denoising with advanced tools such as MATLAB. The prediction results can distinguish outside the rectification side fault, within the rectification side fault, and outside the inverter fault with an accuracy of 100%. A large number of simulations demonstrate that combining singular spectrum entropy with support vector machines (SVM) has emerged as a robust technique for integrated community energy systems, suggesting its potential as a standard method in UHVDC transmission line diagnosis. This study is of significant reference for realizing the complementarity of multiple types of power supply and ensuring a reliable power supply.
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- 2024
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63. Metabolite differences in the medial prefrontal cortex in schizophrenia patients with and without persistent auditory verbal hallucinations: a
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Qianjin, Wang, Honghong, Ren, Chunwang, Li, Zongchang, Li, Jinguang, Li, Hong, Li, Lulin, Dai, Min, Dong, Jun, Zhou, Jingqi, He, Joseph, O'Neill, Yanhui, Liao, Ying, He, Tieqiao, Liu, Xiaogang, Chen, and Jinsong, Tang
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Aspartic Acid ,Hallucinations ,Proton Magnetic Resonance Spectroscopy ,Schizophrenia ,Humans ,Prefrontal Cortex - Abstract
Studies of schizophrenia (SCZ) have associated auditory verbal hallucinations (AVH) with structural and functional abnormalities in frontal cortex, especially medial prefrontal cortex (mPFC). Although abnormal prefrontal network connectivity associated with language production has been studied extensively, the relationship between mPFC dysfunction (highly relevant to the pathophysiology of SCZ) and AVH has been rarely investigated. In this study, proton magnetic resonance spectroscopy was used to measure metabolite levels in the mPFC in 61 SCZ patients with persistent AVH (pAVH), 53 SCZ patients without AVH (non-AVH), and 59 healthy controls (HC). The pAVH group showed significantly lower levels of N-acetyl-aspartate + N-acetyl-aspartyl-glutamate (tNAA) and glutamate + glutamine (Glx), compared with the non-AVH (tNAA: p = 0.022, Glx: p = 0.012) and HC (tNAA: p = 0.001, Glx: p = 0.001) groups. No difference was found in the levels of tNAA and Glx between non-AVH and HC. The levels of tNAA and Glx in the mPFC was negatively correlated with the severity of pAVH (tNAA: r = -0.24, p = 0.014; Glx: r = -0.30, p = 0.002). In conclusion, pAVH in SCZ patients might be related to decreased levels of tNAA and Glx in the mPFC, indicating that tNAA or Glx might play a key role in the pathogenesis of pAVH.
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- 2020
64. Crop rotation and native microbiome inoculation restore soil capacity to suppress a root disease
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Yanyan Zhou, Zhen Yang, Jinguang Liu, Xudong Li, Xingxiang Wang, Chuanchao Dai, Taolin Zhang, Víctor J. Carrión, Zhong Wei, Fuliang Cao, Manuel Delgado-Baquerizo, and Xiaogang Li
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Science - Abstract
Abstract It is widely known that some soils have strong levels of disease suppression and prevent the establishment of pathogens in the rhizosphere of plants. However, what soils are better suppressing disease, and how management can help us to boost disease suppression remain unclear. Here, we used field, greenhouse and laboratory experiments to investigate the effect of management (monocropping and rotation) on the capacity of rhizosphere microbiomes in suppressing peanut root rot disease. Compared with crop rotations, monocropping resulted in microbial assemblies that were less effective in suppressing root rot diseases. Further, the depletion of key rhizosphere taxa in monocropping, which were at a disadvantage in the competition for limited exudates resources, reduced capacity to protect plants against pathogen invasion. However, the supplementation of depleted strains restored rhizosphere resistance to pathogen. Taken together, our findings highlight the role of native soil microbes in fighting disease and supporting plant health, and indicate the potential of using microbial inocula to regenerate the natural capacity of soil to fight disease.
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- 2023
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65. Research on Temperature-Rise Characteristics of Motor Based on Simplified Lumped-Parameter Thermal Network Model
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Jinguang Liang, Kaijie Liang, Zhengri Shao, Yihong Niu, Xiaobei Song, Ping Sun, and Jincheng Feng
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permanent magnet synchronous motor ,lumped parameter thermal network ,temperature-rise characteristics ,motor thermal management ,Technology - Abstract
The thermal management of a driving motor is related to the performance and economy of the vehicle. The lumped-parameter thermal network (LPTN) method can provide a model basis for motor temperature-rise control and effectively shorten the development cycle of motor thermal performance design. In this study, an 80 kw water-cooled permanent magnet synchronous motor was used and the accurate thermal model of a motor was built using the LPTN. On the basis of the accurate thermal model, the simplified thermal model of a motor was obtained by reducing the complexity of the model. The temperature-rise test of the end winding and magnetic steel of the motor was carried out under some working conditions. The test conditions were selected according to continuous external characteristics and operating characteristics of the motor. Compared with the experimental results, the temperature-rise error of the two thermal models was less than 5%. The temperature-rise error of the simplified thermal model was less than 3% compared with the accurate thermal model. Therefore, the simplified thermal model can be used to quickly predict the temperature rise of the motor.
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- 2024
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66. The prescription patterns and safety profiles of oral non-steroidal anti-inflammatory drugs in China: an 8-year real-life analysis
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Jinguang Li, Zhiwei Guo, Na Wang, Jinqiang Wang, Xiaoran Ye, Faxin Li, Qingjun Meng, Zhen Zhang, and Yi Li
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musculoskeletal diseases ,medicine.medical_specialty ,China ,Disease ,030204 cardiovascular system & hematology ,digestive system ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,In patient ,030212 general & internal medicine ,Medical prescription ,skin and connective tissue diseases ,Adverse effect ,Advanced and Specialized Nursing ,Nonsteroidal ,Cyclooxygenase 2 Inhibitors ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,digestive system diseases ,Anesthesiology and Pain Medicine ,Prescriptions ,Non steroidal anti inflammatory ,chemistry ,Pharmaceutical Preparations ,business - Abstract
BACKGROUND This study aimed to evaluate the prescription patterns and safety profiles of oral nonsteroidal anti-inflammatory drugs (NSAIDs) in three Chinese hospitals. METHODS The study analyzed the data of 50,732 patients who were prescribed oral NSAIDs from July 1, 2012 to August 31, 2019. The characteristics of these patients, the prescription patterns of NSAIDs, and the drug-related safety profiles were evaluated. RESULTS Oral NSAIDs were prescribed to patients of all ages. Of the patients, 81.88% were prescribed NSAIDs on only one occasion, and 91.64% were prescribed one type of NSAID only. The combination of different NSAIDs accounted for 2,360 person-times. Orthopedic departments most commonly used selective cyclo-oxygenase-2 (COX-2) inhibitors, while emergency departments most commonly used traditional NSAIDs. The incidences of gastrointestinal (GI) complications, cardiovascular (CV) events, and newonset hypertension were lower in patients treated with selective COX-2 inhibitors than those treated with traditional NSAIDs and NSAID combinations (P
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- 2020
67. Optical experiments on the effect of turbulent jet ignition on lean burning and engine knocking
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Shaodong Zhang, Haiqiao Wei, Lin Chen, Ren Zhang, Jiaying Pan, Jinguang Li, and Yang Penghui
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Thermal efficiency ,Materials science ,General Chemical Engineering ,Nuclear engineering ,Organic Chemistry ,Energy Engineering and Power Technology ,Bandwidth throttling ,Flame speed ,Combustion ,law.invention ,Ignition system ,Fuel Technology ,Volume (thermodynamics) ,law ,Compression ratio ,Engine knocking - Abstract
Recently the turbulent jet ignition (TJI) configured by pre-chamber has been paid more attention as it can effectively achieve rapid combustion thus high thermal efficiency. In this work, using a single-cylinder optical engine with high compression ratios, the effects of turbulent jet ignition on lean burning and engine knocking were comprehensively investigated, with the conventional spark-ignition scenarios for comparisons. The results show that the pre-chamber with larger volume results in stronger flame jets and a higher promoting effect on the combustion. However, due to the higher heat dissipation and throttling loss, the pre-chamber with larger volume results in lower IMEP. For lean combustion, the optimized TJI (small volume) can reduce the combustion instability and improve the thermal efficiency when compared to spark ignition. The main reason is that TJI can increase the in-cylinder flame speed and achieve a concentrated HRR. For knocking combustion, TJI increases the knock tendency and knock intensity. The main reason is that the accelerated flame advances the auto-ignition and induces a high energy density. In summary, the effect of TJI on engine performance differs under different load conditions and the TJI strategy should be optimized especially under heavy load conditions.
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- 2022
68. Effect of Ca Content on the Mechanical Properties and Corrosion Behaviors of Extruded Mg–7Li–3Al Alloys
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Xiaodong Peng, Yan Yang, Minmin Li, Xiaoming Xiong, Guobing Wei, Jinguang Li, and Hongju Deng
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lcsh:TN1-997 ,Materials science ,Alloy ,02 engineering and technology ,engineering.material ,mechanical properties ,01 natural sciences ,Corrosion ,Phase (matter) ,0103 physical sciences ,Ultimate tensile strength ,General Materials Science ,Mg–7Li–3Al alloy ,Composite material ,lcsh:Mining engineering. Metallurgy ,010302 applied physics ,corrosion ,Metals and Alloys ,021001 nanoscience & nanotechnology ,Microstructure ,extrusion ,engineering ,Dynamic recrystallization ,Extrusion ,Elongation ,0210 nano-technology - Abstract
The effect of Ca addition on the microstructure, mechanical properties, and corrosion behaviors of the extruded Mg&ndash, 7Li&ndash, 3Al alloys was investigated. The results showed that the extruded Mg&ndash, 3Al&ndash, xCa alloys consisted of &alpha, Mg (hcp) + &beta, Li (bcc) matrix phases and Al2Ca. With increasing Ca content, the amount and morphology of the Al2Ca phase changed significantly. The grains of the extruded Mg&ndash, xCa alloys were refined by dynamic recrystallization during the extrusion process. The tensile tests results indicated that the extruded Mg&ndash, 0.4Ca alloy exhibited favorable comprehensive mechanical properties, its ultimate tensile strength was 286 MPa, the yield strength was 249 MPa, and the elongation was 18.7%. The corrosion results showed that this alloy with 0.4 wt.% Ca addition exhibited superior corrosion resistance, with a corrosion potential Ecorr of &minus, 1.48742 VVSE, attributed to the formation of protective Al2Ca phases.
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- 2019
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69. Global burden of cardiovascular diseases attributed to low physical activity: An analysis of 204 countries and territories between 1990 and 2019
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Yanfang Luo, Jinguang Liu, Jinshan Zeng, and Hailin Pan
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Global burden of disease ,Cardiovascular diseases ,Low physical activity ,Disability-adjusted life years ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Public aspects of medicine ,RA1-1270 - Abstract
Background: Low physical activity is a major risk factor for cardiovascular diseases (CVDs). This study aimed to estimate the global, regional, national, and sex-age-specific burden of CVDs attributed to low physical activity from 1990 to 2019. Methods: We leveraged data from the Global Burden of Disease Study 2019 to compute the number of fatalities, disability-adjusted life years (DALYs), age-adjusted mortality rates (ASMR), and age-adjusted DALY rates (ASDR) attributed to CVDs resulting from low physical activity. Furthermore, we scrutinized the trends and correlations of these metrics in connection with the socio-demographic index (SDI) across 21 regions and 204 countries and territories. Results: The global deaths and DALYs due to CVDs caused by low physical activity increased from 371,042.96 [95 % UI: 147,621.82–740,490] and 6,282,524.95 [95 % UI: 2,334,970.61–13,255,090.08] in 1990 to 639,174.92 [95 % UI: 272,011.34–1,216,528.4] and 9,996,080.17 [95 % UI: 4,130,111.16–20,323,339.89] in 2019, respectively. The corresponding ASMR and ASDR decreased from 12.55 [95 % UI: 5.12–24.23] and 181.64 [95 % UI: 71.59–374.01] in 1990 to 8.6 [95 % UI: 3.68–16.28] and 127.52 [95 % UI: 53.07–256.55] in 2019, respectively. Deaths and DALYs attributed to low physical activity were initially higher in males but shifted to females after 70–74 age group. Both genders had increasing death rates, peaking at 80–84 age group. Most CVDs deaths and DALYs number are caused by ischemic heart disease. The highest burden of CVDs attributed to low physical activity was observed in North Africa and the Middle East. The lowest burden was observed in Oceania and High-income Asia Pacific. There was a distinctive 'n-shape' relationship between the regional SDI and the ASDR of CVDs attributed to low physical activity from 1990 to 2019. Conclusion: The global impact of CVDs stemming from low physical activity remains substantial and demonstrates substantial regional disparities. As individuals age, this burden becomes more prominent, particularly among females. Efficacious interventions are imperative to promote physical activity and mitigate the risk of CVDs across diverse populations and regions.
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- 2024
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70. Application of Inverse Design Method in Transonic Turbine Blade
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Jinguang Li and Hu Wu
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Physics::Fluid Dynamics ,Flow control (data) ,Overall pressure ratio ,Blade (geometry) ,Turbine blade ,law ,Inverse ,Mechanics ,Wake ,Transonic ,Smoothing ,Mathematics ,law.invention - Abstract
In order to reduce the wake mixing losses of a transonic turbine blade, based on inverse design theory, the modification of a transonic turbine blade is studied by load-camber inverse design method. The inverse design method is based on the three-dimensional Reynolds-Averaged Navier-Stokes equations. Blade profiles are constantly modified by a virtual wall velocity which is obtained from the difference between the current and prescribed load. The spring-based smoothing method is applied to update the mesh. The results show that the wake mixing losses is significantly reduced, and the pressure ratio and efficiency are improved compared with those before modification.
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- 2019
71. 17β-Estradiol promotes metastasis in triple-negative breast cancer through the Calpain/YAP/β-catenin signaling axis.
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Xuemei Niu, Jianan Wang, Jinguang Liu, Qinglong Yu, and Mingwei Ci
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Medicine ,Science - Abstract
β-catenin is an important regulator of malignant progression. 17β-Estradiol (E2), an important sex hormone in women, promotes the growth and metastasis of triple-negative breast cancer (TNBC). However, whether β-catenin is involved in E2-induced metastasis of TNBC remains unknown. In this study, we show that E2 induces the proliferation, migration, invasion, and metastasis of TNBC cells. E2 induces β-catenin protein expression and nuclear translocation, thereby regulating the expression of target genes such as Cyclin D1 and MMP-9. The inhibition of β-catenin reversed the E2-induced cell malignant behaviors. Additionally, E2 activated Calpain by increasing intracellular Ca2+ levels and reducing calpastatin levels. When Calpain was inhibited, E2 did not induce the proliferation, migration, invasion, or metastasis of TNBC cells. In addition, E2 promoted translocation of YAP into the nucleus by inhibiting its phosphorylation. Calpain inhibition reversed the E2-induced YAP dephosphorylation. Inhibition of YAP transcriptional activity reversed the effects of E2 on the proliferation, migration, invasion, and β-catenin of TNBC cells. In conclusion, we demonstrated that E2 induced metastasis-related behaviors in TNBC cells and this effect was mediated through the Calpain/YAP/β-catenin signaling pathway.
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- 2024
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72. Microstructure and corrosion behavior of as-extruded Mg-6.5Li-xY-yZn alloys
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Xiaodong Peng, Xiaoming Xiong, Faping Hu, Yan Yang, Jinguang Li, Hongju Deng, Minmin Li, and Junfei Su
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Materials science ,Mechanical Engineering ,Metallurgy ,Alloy ,Metals and Alloys ,02 engineering and technology ,engineering.material ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Electrochemistry ,Microstructure ,01 natural sciences ,0104 chemical sciences ,Corrosion ,Mechanics of Materials ,Phase (matter) ,Materials Chemistry ,engineering ,Extrusion ,Hydrogen evolution ,0210 nano-technology ,Corrosion behavior - Abstract
The as-cast Mg-6.5Li-xY-yZn alloys (Mg-6.5Li-0.8Y, Mg-6.5Li-0.8Y-0.3Zn and Mg-6.5Li-1.0Y-1.0Zn) were extruded at 553 K with an extrusion ratio of 25:1 and a constant extrusion speed of 1.6 mm/s. The microstructure and corrosion behavior of as-extruded Mg-6.5Li-xY-yZn alloys were studied by microstructure observation, weight loss test, hydrogen evolution test and electrochemical test in present work. The microstructure shows that the Mg-6.5Li-0.8Y alloy contains α-Mg, β-Li and Mg2Y phase, the Mg-6.5Li-0.8Y-0.3Zn alloy is composed of α-Mg, β-Li and X phase (Mg12ZnY, LPSO phase) and the Mg-6.5Li-1.0Y-1.0Zn alloy consists of α-Mg, β-Li and W phase (Mg3Zn3Y2). The corrosion results indicate that the combining addition of Y and Zn can improve the corrosion resistance of Mg-6.5Li alloys and Mg-6.5Li-0.8Y-0.3Zn alloy with LPSO phase possesses the best corrosion resistance. The surface microstructure of test alloys after immersed in 3.5 wt% NaCl solution for 48 h, showing that the Mg-6.5Li-0.8Y alloy has the most corrosion pits while the Mg-6.5Li-0.8Y-0.3Zn alloy has the least corrosion pits due to the minimal micro-galvanic formed on its surface.
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- 2020
73. Research on Fast Determination of Feeder Fault Based on Intelligent Alarm
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Songlin Luo, Shoubin Chen, and Jinguang Li
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ALARM ,Computer science ,Real-time computing ,Fault (power engineering) - Abstract
According to the present situation that it is difficult for power dispatcher to identify and handle different types of feeder faults in time. This paper analyses the relationship between different types of feeder faults and 10kV bus grounding signal, 10kV bus voltage changes, bus grounding signal frequency, feeder switch trip signal, load change of fault feeder. On this basis, the mathematical calculation model based on the calculation of alarm signal and Telemetry data calculation is established. Then sends out intelligent alarm based on calculation results. It can quickly distinguish all kinds of faults, the accuracy of judgment is over 98%. It greatly improves the accuracy and efficiency of fault judgment and handling, also reduces user outage and risk of personal electric shock.
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- 2020
74. Effects of Solid Frmented Bran on the Quality of Dough and Noodles
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Saimin WANG, Yang YU, Jinguang LIU, Yuyao ZHANG, and Zhongkai ZHOU
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solid-state fermentation ,wheat bran ,rheological property ,whole-wheat noodles ,digestive property ,Food processing and manufacture ,TP368-456 - Abstract
In this paper, the effect of solid fermented bran on dough as well as noodle quality was investigated by using lactic acid bacteria and yeast to ferment bran, through paste characteristics, dynamic rheology, noodle texture and in vitro digestion. The results showed that the insoluble dietary fibre content of the fermented bran was significantly lower (P
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- 2023
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75. Y2O3-promoted NiO/SBA-15 catalysts highly active for CO2/CH4 reforming
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Chun Xia, Bing Liu, Jinguang Li, and Chak Tong Au
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Materials science ,Renewable Energy, Sustainability and the Environment ,Non-blocking I/O ,Energy Engineering and Power Technology ,Nanoparticle ,Nanotechnology ,Condensed Matter Physics ,Methane ,Catalysis ,chemistry.chemical_compound ,Fuel Technology ,Physisorption ,chemistry ,High-resolution transmission electron microscopy ,Mesoporous material ,Space velocity ,Nuclear chemistry - Abstract
A series of Y 2 O 3 -promoted NiO/SBA-15 (9 wt% Ni) catalysts (Ni:Y weight ratio = 9:0, 3:1, 3:2, 1:1) were prepared using a sol–gel method. The fresh as well as the catalysts used in CO 2 reforming of methane were characterized using N 2 -physisorption, XRD, FT-IR, XPS, UV, HRTEM, H 2 -TPR, O 2 -TPD and TG techniques. The results indicate that upon Y 2 O 3 promotion, the Ni nanoparticles are highly dispersed on the mesoporous walls of SBA-15 via strong interaction between metal ions and the HO–Si-groups of SBA-15. The catalytic performance of the catalysts were evaluated at 700 °C during CH 4 /CO 2 reforming at a gas hourly space velocity of 24 L g cat −1 h −1 (at 25 ° C and 1 atm) and CH 4 /CO 2 molar ratio of 1. The presence of Y 2 O 3 in NiO/SBA-15 results in enhancement of initial catalytic activity. It was observed that the 9 wt% Y–NiO/SBA-15 catalyst performs the best, exhibiting excellent catalytic activity, superior stability and low carbon deposition in a time on stream of 50 h.
- Published
- 2014
76. Searchable Re-encryption Cloud Storage Method Based on Markov Chain
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Hui, Wang, primary, Sheng, Wang Zhong, additional, and Jinguang, Li, additional
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- 2018
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77. Preparation and Electrochemical Research of Anode Catalyst PtRuNi/C for Direct Methanol Fuel Cell
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Qunjie Xu, Qiaoxia Li, Jinguang Li, and Xiaojin Zhou
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Biomaterials ,Anode catalyst ,Direct methanol fuel cell ,Renewable Energy, Sustainability and the Environment ,Chemistry ,Inorganic chemistry ,Bioengineering ,Electrochemistry - Published
- 2013
78. Can commonly-used fan-driven air cleaning technologies improve indoor air quality? A literature review
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Pawel Wargocki, Jan Sundell, Yuguo Li, Jensen Zhang, Jinguang Li, Wenhao Chen, Jinhan Mo, Richard L. Corsi, Yuexia Sun, Qihong Deng, Michael H.K. Leung, John C. Little, Yinping Zhang, and Lei Fang
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Air cleaner ,IAQ, indoor air quality ,Atmospheric Science ,Engineering ,CADR, clean air delivery rate ,Air pollution ,Scientific literature ,medicine.disease_cause ,Clean Air Delivery Rate ,law.invention ,HEPA, high efficiency particulate air ,Plasma ,Indoor air quality ,law ,ESP, electrostatic precipitator ,Ion generator ,Indoor air quality (IAQ) ,General Environmental Science ,Electrostatic precipitator ,Waste management ,Energy consumption ,Thermal catalytic oxidation (TCO) ,SP, submicron particles ,Ventilation (architecture) ,Sorption ,UVGI, ultraviolet germicidal irradiation ,SVOC, semi-volatile organic compound ,Ultraviolet germicidal irradiation (UVGI) ,AC, activated carbon ,DBD, dielectric barrier discharge ,By-product ,EPA, Environmental Protection Agency ,Article ,WHO, World Health Organization ,Transport engineering ,Ozone ,Benchmark (surveying) ,SOA, secondary organic aerosol ,medicine ,CFM, cubic feet per minute ,PCO, photocatalytic oxidation ,Air quality index ,VOC, volatile organic compound ,business.industry ,TCO, thermal catalytic oxidation ,Clean air delivery rate (CADR) ,BTEX, benzene, toluene, ethyl benzene, and xylene ,TVOC, total volatile organic compound ,High efficiency particulate air (HEPA) ,UV-C, ultraviolet C, wavelength range: 280–100 nm ,business ,Photocatalytic oxidation (PCO) - Abstract
Air cleaning techniques have been applied worldwide with the goal of improving indoor air quality. The effectiveness of applying these techniques varies widely, and pollutant removal efficiency is usually determined in controlled laboratory environments which may not be realized in practice. Some air cleaners are largely ineffective, and some produce harmful by-products. To summarize what is known regarding the effectiveness of fan-driven air cleaning technologies, a state-of-the-art review of the scientific literature was undertaken by a multidisciplinary panel of experts from Europe, North America, and Asia with expertise in air cleaning, aerosol science, medicine, chemistry and ventilation. The effects on health were not examined. Over 26,000 articles were identified in major literature databases; 400 were selected as being relevant based on their titles and abstracts by the first two authors, who further reduced the number of articles to 160 based on the full texts. These articles were reviewed by the panel using predefined inclusion criteria during their first meeting. Additions were also made by the panel. Of these, 133 articles were finally selected for detailed review. Each article was assessed independently by two members of the panel and then judged by the entire panel during a consensus meeting. During this process 59 articles were deemed conclusive and their results were used for final reporting at their second meeting. The conclusions are that: (1) None of the reviewed technologies was able to effectively remove all indoor pollutants and many were found to generate undesirable by-products during operation. (2) Particle filtration and sorption of gaseous pollutants were among the most effective air cleaning technologies, but there is insufficient information regarding long-term performance and proper maintenance. (3) The existing data make it difficult to extract information such as Clean Air Delivery Rate (CADR), which represents a common benchmark for comparing the performance of different air cleaning technologies. (4) To compare and select suitable indoor air cleaning devices, a labeling system accounting for characteristics such as CADR, energy consumption, volume, harmful by-products, and life span is necessary. For that purpose, a standard test room and condition should be built and studied. (5) Although there is evidence that some air cleaning technologies improve indoor air quality, further research is needed before any of them can be confidently recommended for use in indoor environments., Highlights ► Active air cleaning technologies are reviewed by an inter multidisciplinary panel. ► The performances including CADR, efficiency, by-products are summarized and compared. ► The problems such as producing harmful by-products etc. are pointed out and analyzed. ► Benchmarks, standard procedure for labeling air cleaner performance are necessary.
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- 2011
79. Restoration of Cullin3 gene expression enhances the improved effects of sonic hedgehog signaling activation for hypertension and attenuates the dysfunction of vascular smooth muscle cells
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Jian Shen, Youqi Li, Menghao Li, Zhiming Li, Huantang Deng, Xiongwei Xie, and Jinguang Liu
- Subjects
CUL3 ,Vascular smooth muscle cells ,Hypertension ,Proliferation ,Migration ,Sonic hedgehog ,Medical technology ,R855-855.5 - Abstract
Abstract Background Hypertension is known as a major factor for global mortality. We aimed to investigate the role of Cullin3 (CUL3) in the regulation of hypertension. Material and methods Human vascular smooth muscle cells (VSMCs) were treated with Angiotensin II (Ang II) to establish a hypertension in vitro model. Cell viability was detected by a cell counting kit-8 (CCK-8) assay. The content of reactive oxygen species (ROS) was evaluated by kit. Transwell assay and TUNEL staining were, respectively, used to assess cell migration and apoptosis. Additionally, the expression of sonic hedgehog (SHH) signaling-related proteins (SHH, smoothened homolog (Smo) and glioblastoma (Gli)) and CUL3 was tested with western blotting. Following treatment with Cyclopamine (Cycl), an inhibitor of SHH signaling, in Ang II-induced VSMCs, cell viability, migration, apoptosis and ROS content were determined again. Then, VSMCs were transfected with CUL3 plasmid or/and treated with sonic hedgehog signaling agonist (SAG) to explore the impacts on Ang II-induced VSMCs damage. In vivo, a hypertensive mouse model was established. Systolic blood pressure and diastolic blood pressure were determined. The histopathologic changes of abdominal aortic tissues were examined using H&E staining. The expression of SHH, Smo, Gli and CUL3 was tested with western blotting. Results Significantly increased proliferation, migration and apoptosis of VSMCs were observed after Ang II exposure. Moreover, Ang II induced upregulated SHH, Smo and Gli expression, whereas limited increase in CUL3 expression was observed. The content of ROS in Ang II-stimulated VSMCs presented the same results. Following Cycl treatment, the high levels of proliferation and migration in Ang II-treated VSMCs were notably remedied while the apoptosis and ROS concentration were further increased. Moreover, Cycl downregulated SHH, Smo, Gli and CUL3 expression. Above-mentioned changes caused by Ang II were reversed following SAG addition. Indeed, SAG treatment combined with restoration of CUL3 expression inhibited proliferation, migration, apoptosis and ROS level in Ang II-stimulated VSMCs. In vivo, SAG aggravated the histopathological changes of the aorta and with a worse tendency after both SAG intervention and CUL3 silencing. By contrast, SAG treatment and rebound in CUL3 expression alleviated the vascular damage. Conclusions Collectively, restoration of CUL3 gene expression protected against hypertension through enhancing the effects of SHH activation in inhibition of apoptosis and oxidative stress for hypertension and alleviating the dysfunction of VSMCs.
- Published
- 2022
- Full Text
- View/download PDF
80. Low-Income Women’s Dietary Intakes Are Sensitive to the Depletion of Household Resources in One Month
- Author
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Valerie Tarasuk, Lynn McIntyre, and Jinguang Li
- Subjects
Adult ,Vitamin ,Low income ,Gerontology ,Food intake ,Time Factors ,Nutritional Status ,Medicine (miscellaneous) ,Context (language use) ,Eating ,chemistry.chemical_compound ,Nutrient ,Environmental health ,Humans ,Medicine ,Poverty ,Receipt ,Nutrition and Dietetics ,Food security ,business.industry ,Middle Aged ,Diet ,Socioeconomic Factors ,chemistry ,Food ,Female ,Energy Metabolism ,business - Abstract
Food insecurity affects individuals' dietary intakes, but there have been few direct examinations of changes in individuals' intakes in the context of declining resources. This study examined changes in dietary intake over 30 d following the receipt of income in a sample of low-income, predominantly food-insecure women with children. Data on 182 women who received the bulk of their income in 1 monthly check were drawn from 2 Canadian studies. Equivalent 30-d measures of adult food security were constructed from participants' responses to items on the Radimer-Cornell questionnaire or the U.S. Household Food Security Survey Module. Intake data from multiple 24-h dietary recalls collected over 1 mo were merged. Mixed linear models were used to examine relationships between women's energy, nutrient, and food intakes and the depletion in household resources over 30 d, as indicated by days since the receipt of the household's major source of income. Women's intakes of energy, milk products, and vegetables decreased significantly as the time since they received income increased. When their food security status was considered, women who were food secure or marginally insecure showed no significant within-month patterns, but significant declines in energy, carbohydrate, vitamin B-6, and fruit and vegetable intake were observed for women with moderate or severe adult food insecurity. The food intakes of women in deprived circumstances are sensitive to the decline in household resources following the receipt of a monthly check.
- Published
- 2007
81. Homeless Youth in Toronto Are Nutritionally Vulnerable
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Jinguang Li, Valerie Tarasuk, and Naomi Dachner
- Subjects
Male ,Vitamin ,Gerontology ,Adolescent ,Urban Population ,Health Behavior ,Medicine (miscellaneous) ,Overweight ,Lower energy ,chemistry.chemical_compound ,Environmental health ,Humans ,Medicine ,Sedentary lifestyle ,Ontario ,Analysis of Variance ,Meal ,Nutrition and Dietetics ,business.industry ,Dietary intake ,Malnutrition ,Nutritional Requirements ,Feeding Behavior ,chemistry ,Adolescent Behavior ,Ill-Housed Persons ,Female ,Energy intakes ,medicine.symptom ,Underweight ,business - Abstract
This study was undertaken to characterize nutritional vulnerability among a sample of homeless youth in downtown Toronto. Interviews were conducted with 261 homeless youth (149 male, 112 female), recruited from drop-in centers and outdoor locations. Information about current living circumstances, nutrition and health-related behaviors, and 24-h dietary intake recalls were collected, and height, weight, triceps skinfold thickness, and mid-upper arm circumference were measured. A second 24-h dietary intake recall was conducted with 195 youth. Youth's energy intakes approximated the requirements for a very sedentary lifestyle; 7% were underweight and 22% were overweight or obese. Over half of the youth had inadequate intakes of folate, vitamin A, vitamin C, magnesium, and zinc; in addition, more than half of females had inadequate vitamin B-12 and iron intakes. Most youth got food from more than one source in the course of a day: 74% of males and 75% of females purchased food; 48% of males and 51% of females obtained food from charitable meal programs; 47% of males and 75% of females received food from strangers or acquaintances; and 10% of males and 6% of females stole food or took it from the garbage. Compared to a sample of 114 domiciled youth from the 1997-1998 Ontario Food Survey, males had lower energy and nutrient intakes and females had lower intakes of most nutrients.
- Published
- 2005
82. Effect of Nitric Acid on Modified Mesoporous Carbon as Catalyst Support of Direct Methanol Fuel Cell
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Hong-min Mao, Qiaoxia Li, Qunjie Xu, and Jinguang Li
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Methanol reformer ,Renewable Energy, Sustainability and the Environment ,Chemistry ,Reducing agent ,Mechanical Engineering ,Catalyst support ,Inorganic chemistry ,Energy Engineering and Power Technology ,Chronoamperometry ,Electronic, Optical and Magnetic Materials ,Catalysis ,Direct methanol fuel cell ,chemistry.chemical_compound ,Chemical engineering ,Mechanics of Materials ,Nitric acid ,Methanol - Abstract
Nitric acid modified Mesoporous carbon (CMK-3) supported Pt particles have been prepared by chemical reduction with NaBH4 as a reducing agent. Energy dispersive spectrometer shows that the catalysts have some oxygenic functional groups. The activity of the composite catalysts for methanol electro-oxidation was investigated by using cyclic votammogram and chronoamperometry in acid media. The results indicated that modified mesoporous carbon can improve the catalytic ability of Pt catalyst for methanol electro-oxidation and antipoison capability for CO. The composite electrode modified by 0.23 g nitric acid has the highest electrochemical ability.
- Published
- 2013
83. Early-age thermal analysis and strain monitoring of massive concrete structures.
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Yan Geng, Xiongyan Li, Suduo Xue, Jinguang Li, and Yanjie Song
- Subjects
THERMAL analysis ,HEAT of hydration ,LIQUEFIED natural gas ,MECHANICAL behavior of materials ,HEAT transfer coefficient - Abstract
Hydration heat and thermal induced cracking have always been a fatal problem for massive concrete structures. In order to study a massive reinforced concrete wall of a storage tank for liquefied natural gas (LNG) during its construction, two mock-ups of 0.8 m×0.8 m×0.8 m without and with metal corrugated pipes were designed based on the actual wall construction plan. Temperature distribution and strain development of both mock-ups were measured and compared inside and on the surface of them. Meanwhile, time-dependent thermal and mechanical properties of the concrete were tested standardly and introduced into the finite-element (FE) software with a proposed hydration degree model. According to the comparison results, the FE simulation of temperature field agreed well with the measured data. Besides, the maximum temperature rise was slightly higher and the shrinkage was generally larger in the mock-up without pipes, indicating that corrugated pipes could reduce concrete temperature and decrease shrinkage of surrounding concrete. In addition, the cooling rate decreased approximately linearly with the reduction of heat transfer coefficient h, implying that a target cooling curve can be achieved by calculating a desired coefficient h. Moreover, the maximum cooling rate did not necessarily decrease with the extension of demoulding time. It is better to remove the formwork at least after 116 hours after concrete casting, which promises lower risk of thermal cracking of early-age concrete. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
84. Chromosome-level genome assembly of a regenerable maize inbred line A188
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Guifang Lin, Cheng He, Jun Zheng, Dal-Hoe Koo, Ha Le, Huakun Zheng, Tej Man Tamang, Jinguang Lin, Yan Liu, Mingxia Zhao, Yangfan Hao, Frank McFraland, Bo Wang, Yang Qin, Haibao Tang, Donald R. McCarty, Hairong Wei, Myeong-Je Cho, Sunghun Park, Heidi Kaeppler, Shawn M. Kaeppler, Yunjun Liu, Nathan Springer, Patrick S. Schnable, Guoying Wang, Frank F. White, and Sanzhen Liu
- Subjects
Maize ,Genome assembly ,Long reads ,Structural variation ,Kernel color ,Biology (General) ,QH301-705.5 ,Genetics ,QH426-470 - Abstract
Abstract Background The maize inbred line A188 is an attractive model for elucidation of gene function and improvement due to its high embryogenic capacity and many contrasting traits to the first maize reference genome, B73, and other elite lines. The lack of a genome assembly of A188 limits its use as a model for functional studies. Results Here, we present a chromosome-level genome assembly of A188 using long reads and optical maps. Comparison of A188 with B73 using both whole-genome alignments and read depths from sequencing reads identify approximately 1.1 Gb of syntenic sequences as well as extensive structural variation, including a 1.8-Mb duplication containing the Gametophyte factor1 locus for unilateral cross-incompatibility, and six inversions of 0.7 Mb or greater. Increased copy number of carotenoid cleavage dioxygenase 1 (ccd1) in A188 is associated with elevated expression during seed development. High ccd1 expression in seeds together with low expression of yellow endosperm 1 (y1) reduces carotenoid accumulation, accounting for the white seed phenotype of A188. Furthermore, transcriptome and epigenome analyses reveal enhanced expression of defense pathways and altered DNA methylation patterns of the embryonic callus. Conclusions The A188 genome assembly provides a high-resolution sequence for a complex genome species and a foundational resource for analyses of genome variation and gene function in maize. The genome, in comparison to B73, contains extensive intra-species structural variations and other genetic differences. Expression and network analyses identify discrete profiles for embryonic callus and other tissues.
- Published
- 2021
- Full Text
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85. Comparative transcriptional and genomic analysis of Plasmodium falciparum field isolates
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Kevin Marsh, Peter R. Preiser, Margaret J. Mackinnon, Moses Kortok, Sachel Mok, Jinguang Li, and Zbynek Bozdech
- Subjects
lcsh:Immunologic diseases. Allergy ,Transcription, Genetic ,Genes, Protozoan ,Plasmodium falciparum ,Immunology ,Biology ,Microbiology ,Genome ,03 medical and health sciences ,Virology ,Gene duplication ,Gene expression ,Genetics ,Copy-number variation ,Molecular Biology ,Gene ,lcsh:QH301-705.5 ,Oligonucleotide Array Sequence Analysis ,030304 developmental biology ,Regulation of gene expression ,0303 health sciences ,Reverse Transcriptase Polymerase Chain Reaction ,030306 microbiology ,Infectious Diseases/Protozoal Infections ,Genetics and Genomics/Gene Expression ,biology.organism_classification ,Phenotype ,3. Good health ,Gene Expression Regulation ,lcsh:Biology (General) ,Parasitology ,lcsh:RC581-607 ,Research Article - Abstract
Mechanisms for differential regulation of gene expression may underlie much of the phenotypic variation and adaptability of malaria parasites. Here we describe transcriptional variation among culture-adapted field isolates of Plasmodium falciparum, the species responsible for most malarial disease. It was found that genes coding for parasite protein export into the red cell cytosol and onto its surface, and genes coding for sexual stage proteins involved in parasite transmission are up-regulated in field isolates compared with long-term laboratory isolates. Much of this variability was associated with the loss of small or large chromosomal segments, or other forms of gene copy number variation that are prevalent in the P. falciparum genome (copy number variants, CNVs). Expression levels of genes inside these segments were correlated to that of genes outside and adjacent to the segment boundaries, and this association declined with distance from the CNV boundary. This observation could not be explained by copy number variation in these adjacent genes. This suggests a local-acting regulatory role for CNVs in transcription of neighboring genes and helps explain the chromosomal clustering that we observed here. Transcriptional co-regulation of physical clusters of adaptive genes may provide a way for the parasite to readily adapt to its highly heterogeneous and strongly selective environment., Author Summary Malaria parasites are particularly good at adapting to the variable environments they encounter during their life cycle. This property helps explain their widespread prevalence and persistence despite massive malaria control campaigns. The genes responsible for this adaptability are largely unknown. In this study we analyzed gene expression profiles of P. falciparum parasites recently taken from the field and compared them to those from laboratory-adapted parasites. Many of the genes that were up-regulated in field isolates coded for proteins which are exported, or involved in export, from the parasite onto the surface of the host cell where they interact with the immune system. Differences at the expression level were partly explainable by variation in gene copy number caused by deletions or amplification of small chromosomal segments. Usually, higher gene copy was associated with elevated expression levels, but for some genes, more copies appeared to repress expression. Remarkably, the regulatory effects of deleted or amplified segments appeared to extend to genes outside the segment boundaries. This suggests an epigenetically mediated co-regulation of tightly linked gene clusters. Such ‘soft-wired’, coordinated adaptation is potentially an important mechanism by which the parasite readily adapts to its current host. The molecules responsible may therefore be important targets for drugs or vaccines.
- Published
- 2009
86. Improving the nutritional status of food-insecure women: first, let them eat what they like
- Author
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Tony Jinguang Li, Lynn McIntyre, and Valerie Tarasuk
- Subjects
Gerontology ,Adult ,Hunger ,Population ,Vulnerability ,Medicine (miscellaneous) ,Nutritional Status ,Social class ,Food group ,Food Preferences ,Nutrient ,Environmental health ,Medicine ,Humans ,education ,Poverty ,Ontario ,education.field_of_study ,Nutrition and Dietetics ,business.industry ,Public Health, Environmental and Occupational Health ,Nutritional status ,Middle Aged ,Diet ,Social Class ,Dietary Reference Intake ,Women's Health ,Female ,business - Abstract
ObjectiveTo determine the extent to which identified nutrient inadequacies in the dietary intakes of a sample of food-insecure women could be ameliorated by increasing their access to the ‘healthy’ foods they typically eat.DesignMerged datasets of 226 food-insecure women who provided at least three 24-hour dietary intake recalls over the course of a month. Dietary modelling, with energy adjustment for severe food insecurity, explored the effect of adding a serving of the woman's own, and the group's typically chosen, nutrient-rich foods on the estimated prevalence of nutrient inadequacy.Setting and subjectsOne study included participants residing in 22 diverse community clusters from the Atlantic Provinces of Canada, and the second study included food bank attendees in Toronto, Ontario, Canada. Of the 226 participants, 78% lived alone with their children.ResultsWhile nutritional vulnerability remained after modelling, adding a single serving of either typically chosen ‘healthy’ foods from women's own diets or healthy food choices normative to the population reduced the prevalence of inadequacy by at least half for most nutrients. Correction for energy deficits resulting from severe food insecurity contributed a mean additional 20% improvement in nutrient intakes.ConclusionsFood-insecure women would sustain substantive nutritional gains if they had greater access to their personal healthy food preferences and if the dietary compromises associated with severe food insecurity were abated. Increased resources to access such choices should be a priority.
- Published
- 2007
87. Improving the nutritional status of food-insecure women: first, let them eat what they like.
- Author
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McIntyre L, Tarasuk V, Jinguang Li T, McIntyre, Lynn, Tarasuk, Valerie, and Jinguang Li, Tony
- Abstract
Objective: To determine the extent to which identified nutrient inadequacies in the dietary intakes of a sample of food-insecure women could be ameliorated by increasing their access to the 'healthy' foods they typically eat.Design: Merged datasets of 226 food-insecure women who provided at least three 24-hour dietary intake recalls over the course of a month. Dietary modelling, with energy adjustment for severe food insecurity, explored the effect of adding a serving of the woman's own, and the group's typically chosen, nutrient-rich foods on the estimated prevalence of nutrient inadequacy.Setting and Subjects: One study included participants residing in 22 diverse community clusters from the Atlantic Provinces of Canada, and the second study included food bank attendees in Toronto, Ontario, Canada. Of the 226 participants, 78% lived alone with their children.Results: While nutritional vulnerability remained after modelling, adding a single serving of either typically chosen 'healthy' foods from women's own diets or healthy food choices normative to the population reduced the prevalence of inadequacy by at least half for most nutrients. Correction for energy deficits resulting from severe food insecurity contributed a mean additional 20% improvement in nutrient intakes.Conclusions: Food-insecure women would sustain substantive nutritional gains if they had greater access to their personal healthy food preferences and if the dietary compromises associated with severe food insecurity were abated. Increased resources to access such choices should be a priority. [ABSTRACT FROM AUTHOR]- Published
- 2007
- Full Text
- View/download PDF
88. Terpenoids of Ganoderma lucidum reverse cognitive impairment through attenuating neurodegeneration via suppression of PI3K/AKT/mTOR expression in vivo model
- Author
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Anqi Wang, Changhao Xiao, Jianxian Zheng, Chuansong Ye, Zhen Dai, Qinghai Wu, Jinguang Liu, Padraig Strappe, and Zhongkai Zhou
- Subjects
Triterpenoids ,Aging ,Oxidative stress ,Inflammation ,PI3K/AKT/mTOR pathway ,Nutrition. Foods and food supply ,TX341-641 - Abstract
This study investigated effects of triterpenoids derived from Ganoderma lucidum (GLT) on the ability to attenuate cognitive impairment and reduce oxidative stress and inflammation induced by D-galactose using an aged rats model. The data revealed that dietary GLT intervention improved the memory of aged rats in a water maze experiment. A reduction in inflammation was also achieved as GLT decreased the levels of MDA, AGEs, NO, TNF-α and AChE activity, and increased the activity of T-AOC, GSH-Px, T-SOD, CAT and IL-2 level in serum. The GLT intervention revised hepatocyte cellular arrangement and binucleation of the liver status, and even hippocampal neurons morphology. GLT upregulated the expression of FOXO4, SIRT1, and downregulated the expression of GFAP, iNOS, PI3K, AKT, mTOR and IL-6 with activation of PI3K/AKT/mTOR pathway. The current study highlights a promising dietary approach for prevention or alleviation of oxidative stress, inflammation and cognitive impairment induced by age-related conditions.
- Published
- 2020
- Full Text
- View/download PDF
89. Chitosan-functionalized lipid-polymer hybrid nanoparticles for oral delivery of silymarin and enhanced lipid-lowering effect in NAFLD
- Author
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Jun Liang, Ying Liu, Jinguang Liu, Zhe Li, Qiangyuan Fan, Zifei Jiang, Fei Yan, Zhi Wang, Peiwen Huang, and Nianping Feng
- Subjects
Chitosan-functioned lipid-polymer hybrid nanoparticle ,Silymarin ,Oral bioavailability ,Lipid-lowering effect ,Non-alcoholic fatty liver disease ,Biotechnology ,TP248.13-248.65 ,Medical technology ,R855-855.5 - Abstract
Abstract Background Non-alcoholic fatty liver disease (NAFLD) is a chronic disease that causes excessive hepatic lipid accumulation. Reducing hepatic lipid deposition is a key issue in treatment and inhibition of NAFLD evolution. Silymarin is a potent hepatoprotective agent; however, it has low oral bioavailability due to its poor aqueous solubility and low membrane permeability. Unfortunately, few studies have addressed the development of convenient oral nanocarriers that can efficiently deliver silymarin to the liver and enhance its lipid-lowering effect. We designed silymarin-loaded lipid polymer hybrid nanoparticles containing chitosan (CS-LPNs) to improve silymarin bioavailability and evaluated their lipid-lowering effect in adiponutrin/patatin-like phospholipase-3 I148M transgenic mice, an NAFLD model. Results Compared to chitosan-free nanoparticles, CS-LPNs showed 1.92-fold higher uptake by fatty liver cells. Additionally, CS-LPNs significantly reduced TG levels in fatty liver cells in an in vitro lipid deposition assay, suggesting their potential lipid-lowering effects. The oral bioavailability of silymarin from CS-LPNs was 14.38-fold higher than that from suspensions in rats. Moreover, compared with chitosan-free nanoparticles, CS-LPNs effectively reduced blood lipid levels (TG), improved liver function (AST and ALT), and reduced lipid accumulation in the livers of mice in vivo. Reduced macrovesicular steatosis in pathological tissue after CS-LPN treatment indicated their protective effect against liver steatosis in NAFLD. Conclusions CS-LPNs enhanced oral delivery of silymarin and exhibited a desirable lipid-lowering effect in a mouse model. These findings suggest that CS-LPNs may be a promising oral nanocarrier for NAFLD therapeutics.
- Published
- 2018
- Full Text
- View/download PDF
90. Comparative Transcriptional and Genomic Analysis of Plasmodium falciparum Field Isolates.
- Author
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Mackinnon, Margaret J., Jinguang Li, Sachel Mok, Kortok, Moses M., Marsh, Kevin, Preiser, Peter R., and Bozdech, Zbynek
- Subjects
- *
PLASMODIUM falciparum , *MALARIA , *PROTOZOAN diseases , *GENE expression , *GENOMES - Abstract
Mechanisms for differential regulation of gene expression may underlie much of the phenotypic variation and adaptability of malaria parasites. Here we describe transcriptional variation among culture-adapted field isolates of Plasmodium falciparum, the species responsible for most malarial disease. It was found that genes coding for parasite protein export into the red cell cytosol and onto its surface, and genes coding for sexual stage proteins involved in parasite transmission are upregulated in field isolates compared with long-term laboratory isolates. Much of this variability was associated with the loss of small or large chromosomal segments, or other forms of gene copy number variation that are prevalent in the P. falciparum genome (copy number variants, CNVs). Expression levels of genes inside these segments were correlated to that of genes outside and adjacent to the segment boundaries, and this association declined with distance from the CNV boundary. This observation could not be explained by copy number variation in these adjacent genes. This suggests a localacting regulatory role for CNVs in transcription of neighboring genes and helps explain the chromosomal clustering that we observed here. Transcriptional co-regulation of physical clusters of adaptive genes may provide a way for the parasite to readily adapt to its highly heterogeneous and strongly selective environment. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
91. Improving the nutritional status of food-insecure women: first, let them eat what they like.
- Author
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Lynn McIntyre, Valerie Tarasuk, and Tony Jinguang Li
- Subjects
SINGLE heterosexual women ,FOOD banks ,FOOD relief - Abstract
AbstractObjectiveTo determine the extent to which identified nutrient inadequacies in the dietary intakes of a sample of food-insecure women could be ameliorated by increasing their access to the ?healthy? foods they typically eat.DesignMerged datasets of 226 food-insecure women who provided at least three 24-hour dietary intake recalls over the course of a month. Dietary modelling, with energy adjustment for severe food insecurity, explored the effect of adding a serving of the woman's own, and the group's typically chosen, nutrient-rich foods on the estimated prevalence of nutrient inadequacy.Setting and subjectsOne study included participants residing in 22 diverse community clusters from the Atlantic Provinces of Canada, and the second study included food bank attendees in Toronto, Ontario, Canada. Of the 226 participants, 78% lived alone with their children.ResultsWhile nutritional vulnerability remained after modelling, adding a single serving of either typically chosen ?healthy? foods from women's own diets or healthy food choices normative to the population reduced the prevalence of inadequacy by at least half for most nutrients. Correction for energy deficits resulting from severe food insecurity contributed a mean additional 20% improvement in nutrient intakes.ConclusionsFood-insecure women would sustain substantive nutritional gains if they had greater access to their personal healthy food preferences and if the dietary compromises associated with severe food insecurity were abated. Increased resources to access such choices should be a priority. [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
- View/download PDF
92. Low-income women's dietary intakes are sensitive to the depletion of household resources in one month.
- Author
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Tarasuk, Valerie, McIntyre, Lynn, Jinguang Li, and Li, Jinguang
- Subjects
DIET ,INGESTION ,POOR women ,WOMEN'S health ,HOUSEHOLDS ,FOOD ,COMPARATIVE studies ,ENERGY metabolism ,RESEARCH methodology ,MEDICAL cooperation ,POVERTY ,RESEARCH ,TIME ,SOCIOECONOMIC factors ,EVALUATION research ,NUTRITIONAL status ,ECONOMICS - Abstract
Food insecurity affects individuals' dietary intakes, but there have been few direct examinations of changes in individuals' intakes in the context of declining resources. This study examined changes in dietary intake over 30 d following the receipt of income in a sample of low-income, predominantly food-insecure women with children. Data on 182 women who received the bulk of their income in 1 monthly check were drawn from 2 Canadian studies. Equivalent 30-d measures of adult food security were constructed from participants' responses to items on the Radimer-Cornell questionnaire or the U.S. Household Food Security Survey Module. Intake data from multiple 24-h dietary recalls collected over 1 mo were merged. Mixed linear models were used to examine relationships between women's energy, nutrient, and food intakes and the depletion in household resources over 30 d, as indicated by days since the receipt of the household's major source of income. Women's intakes of energy, milk products, and vegetables decreased significantly as the time since they received income increased. When their food security status was considered, women who were food secure or marginally insecure showed no significant within-month patterns, but significant declines in energy, carbohydrate, vitamin B-6, and fruit and vegetable intake were observed for women with moderate or severe adult food insecurity. The food intakes of women in deprived circumstances are sensitive to the decline in household resources following the receipt of a monthly check. [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
- View/download PDF
93. Root Cause Analysis of the Influencing Factors of Professional Identity in Rural Order-oriented Medical Students: a Qualitative Research
- Author
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QIAO Xue, YIN Yongtian, LUO Wenjun, LI Yinghui, YANG Jinguang, LI Jingwei, CHEN Hongzhi
- Subjects
occupations ,social identification ,root cause analysis ,professional identity ,rural order oriented medical students ,grounded theory ,qualitative research ,Medicine - Abstract
Background With the continuous development of the training program of rural order-oriented medical students (referred to as publicly-funded medical students) in China, the talent team of general practice is constantly enriched, and the professional identity status and its influencing factors in rural order-oriented medical students have become the focus of current attention. Objective To analyze the influencing factors of professional identity in rural order-oriented medical students. Methods Purposive sampling method was used to interview the 30 rural order-oriented medical students from 2018 to 2022 grade of Traditional Chinese Medicine (five-year system) Beneficiary Class of Shandong University of Traditional Chinese Medicine by semi-structured interviews from December 2022 to March 2023. The interview data were coded and analyzed by using open coding, axial coding, and selective coding, following the Anselm Strauss and Juliet Corbin programmatic grounded theory approach. Results A total of 482 initial concepts and 47 basic categories were extracted by open coding, 9 main categories obtained by axial coding. A typical relationship structure was formed by selective coding, and it showed that the influencing factors of professional identity in rural order-oriented medical students were consisted with six dimensions of career cognition, career behavior, career choice, career will, career emotion, and career belief. Conclusion The influencing factors of professional identity in rural order-oriented medical students are composed of six dimensions, including career cognition, career behavior, career choice, career will, career emotion, and career belief, of which career cognition, career behavior, and career choice belong to the exogenous factors, while career will, career belief, and career emotion belong to the implicit factors.
- Published
- 2024
- Full Text
- View/download PDF
94. Passing Stages Division of the Pedestrians and Bicycles Conglomeration at Signalized Intersection of Chinese City
- Author
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Ting Xu, Jinguang Liu, and Shuai Dai
- Subjects
Mechanical engineering and machinery ,TJ1-1570 - Abstract
This paper mainly studies how to divide the passing stages of the pedestrians and bicycles conglomeration at signalized intersection in Chinese urban area. The conception of pedestrians and bicycles conglomeration is defined after analyzing the two-stage characteristics of pedestrians and bicycles groups. Seven intersections were chosen in Beijing as examples. After video analysis, the real-time displacement and the real-time velocities of seven intersections in one signal cycle are extracted. It is found that the procedure of pedestrians and bicycles passing the intersection can be divided into two stages, which shows distinct characteristics. Video records taken from the observational survey are used to extract the real displacement of pedestrians and bicycles and the passing behaviors images. A new approach is presented to calculate the occupation ratio of the pedestrians and bicycles conglomeration, based on the “suppositional grids” division of the effective crosswalks. Finally, the grey relational analysis is applied to divide the mixed groups’ passing stages based on the occupation ratio of conglomeration. A signalized intersection in Beijing is presented as a case study, and the passing stages are clustered into four stages from initial five stages and the results indicate that the trend of change in different stages is obvious.
- Published
- 2015
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