51. RXRα agonist bexarotene attenuates radiation-induced skin injury by relieving oxidative stress
- Author
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Sheng Jiang, Weichao Cai, Jianhui Chen, Wenling Tu, Yulan Liu, Lixin Gong, Yahui Feng, Wei Mo, Tao Yan, Shuyu Zhang, and Daojiang Yu
- Subjects
Radiation ,Skin injury ,Oxidative stress ,RXRα ,Bexarotene ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Objective: To investigate the protective effect of bexarotene in radiation-induced skin injury and elucidate underlying mechanism. Methods: Irradiated cellular and animal models were established using an X-ray linear accelerator. Cell viability and apoptosis were evaluated by CCK8 and flow cytometry. In vivo protective effect of bexarotene was measured in irradiated SD rats. The antioxidant capacity of bexarotene was validated by DCF-DA method. The signaling pathways involved in bexarotene-mediated skin repair were enriched by RNA sequencing. Results: Bexarotene could significantly restore the proliferation and inhibit the apoptosis of WS1 cells with radiation damage (P
- Published
- 2022
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