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Abstract: Ordered mesoporous carbon (OMC)–SnO2 nanocomposite was prepared by a melt injection method using SnCl2·2H2O as the tin source. The results of X-ray diffraction (XRD) indicated that tin dioxide in the nanocomposite was crystalline. The BJH adsorption average pore size was greatly reduced from 5.1nm for OMC to 2.9nm for the mesoporous OMC–SnO2 composite which is due to the partial occupation of the pores by the tin species incorporated into the mesoporous carbon. The OMC–SnO2 electrode exhibits excellent cycle stability: the retentive capacity (472.1mAh/g) up to 30 cycles is 62.2% of the initial capacity (758.2mAh/g) which is much better than that for commercial SnO2. These results suggest that OMC–SnO2 nanocomposite would be a promising anode material for lithium ion battery. [Copyright &y& Elsevier]

Objective: We aimed to examine the relationship between osteocalcin (OC) and the risk of incident diabetes and the risk of incident diabetic kidney disease (DKD)., Research Design and Methods: We followed 5,396 participants without diabetes (nondiabetes subcohort) and 1,174 participants with diabetes and normal kidney function (diabetes subcohort) at baseline. Logistic regression and modified Poisson regression models were used to estimate the relative risk (RR) of baseline OC levels with incident diabetes and DKD., Results: During a mean 4.6-year follow-up period, 296 cases of incident diabetes and 184 cases of incident DKD were identified. In the nondiabetes subcohort, higher OC levels were linearly associated with a decreased risk of diabetes (RR for 1-unit increase of loge-transformed OC 0.51 [95% CI 0.35-0.76]; RR for highest vs. lowest quartile 0.65 [95% CI 0.44-0.95]; P for trend < 0.05). In the diabetes subcohort, OC levels were linearly inversely associated with incident DKD (RR for 1-unit increase of loge-transformed OC 0.49 [95% CI 0.33-0.74]; RR for highest vs. lowest quartile 0.56 [95% CI 0.38-0.83]; P for trend < 0.05), even independent of baseline estimated glomerular filtration rate and urinary albumin-to-creatinine ratio. No significant interactions between OC and various subgroups on incident diabetes or DKD were observed., Conclusions: Lower OC levels were associated with an increased risk of incident diabetes and DKD., (© 2022 by the American Diabetes Association.)

Diabetes mellitus is a prevalent disease result in several complications, including bone problems. Previous studies have shown that microRNA (miR)-26a regulates glucose metabolism and plays a protective role in diabetes. However, whether miR-26a also affects bone quality in diabetes remains unknown. In the present study, we evaluated the potential effects of miR-26a on bone in diabetic mice. We administrated miR-26a in streptozotocin-induced diabetic mice. The metabolic parameters, bone quality, osteoblast and osteoclast markers, and insulin signaling activation were measured. miR-26a ameliorated insulin resistance and glucose tolerance, improved bone microarchitecture and quality, increased osteoblasts and bone formation, decreased osteoclasts, and promoted the insulin signaling pathway in diabetic mice. These effects were abolished in insulin receptor-compromised Col1a1-Insr +/- mice. In conclusion, miR-26a could ameliorate bone-specific insulin resistance and bone quality in diabetic mice, which depended on the insulin receptors on osteoblasts. Our findings highlight the potential of miR-26a as a therapeutic target for diabetes mellitus-related bone metabolism and diseases., (Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)