51. Design, synthesis and antibacterial activity of a novel alkylide: 3-O-(3-aryl-propenyl)clarithromycin derivatives
- Author
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Yue-Ying Wang, Jian-Hua Liang, Rui Wang, Guo-Wei Yao, Li-Jing Dong, Dan-Yang Zhu, and Mao-Mao An
- Subjects
Pharmacology ,Propenyl ,Magnetic Resonance Spectroscopy ,Stereochemistry ,Chemistry ,Aryl ,Erythromycin ,Ether ,medicine.disease_cause ,Anti-Bacterial Agents ,chemistry.chemical_compound ,Structure-Activity Relationship ,Staphylococcus aureus ,Clarithromycin ,Drug Design ,Drug Discovery ,medicine ,Antibacterial activity ,Staphylococcus ,medicine.drug - Abstract
A series of novel 3-O-(3-aryl-propenyl)clarithromycin derivatives were designed, synthesized and evaluated for their in vitro antibacterial activities. Regioselective allylation at 3-OH was efficiently achieved in the presence of 9-oxime ether, compared with 9-keto. Most of the side chains were identified as the 3-O-(3-aryl-Z-prop-1-enyl) group, not the expected 3-O-(3-aryl-E-prop-2-enyl) group. Some derivatives of this series showed improved activities against erythromycin-resistant Staphylococcus aureus and Staphylococcus pneumoniae compared with the reference compound, clarithromycin, but weaker activities against susceptible strains.
- Published
- 2009