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Objective Intestinal mucosal barrier damage is an important mechanism for the development of sepsis and multiple organ dysfunction syndrome. At present, there are no satisfactory and effective methods for the protection of the intestinal mucosal barrier. Jinzhi, the first fecal microbiota transplantation worldwide, is often used to treat critically ill patients; however, the specific mechanism involved in this process remains unclear. The aim of this study was to investigate the therapeutic effect and mechanism of Jinzhi intervention on mice with sepsis induced through treatment with lipopolysaccharide (LPS). Methods Mice were intraperitoneally injected with LPS to simulate intestinal mucosal barrier function damage in sepsis; intervention was performed through the oral administration of Jinzhi. The effect of Jinzhi on LPS-induced sepsis was analyzed by comparing the vital signs and survival rate of mice under different treatments. Pathological staining and enzyme-linked immunosorbent assay were used to identify the effects of LPS or treatment with Jinzhi on the intestinal mucosal barrier in mice. The effect of LPS or treatment with Jinzhi on the intestinal flora was analyzed via 16S rRNA gene sequencing of ileal contents. Results Immunohistochemistry and enzyme-linked immunosorbent assay showed that treatment with LPS increased levels of inflammatory factors (interleukin-1α, interleukin-6, tumor necrosis factor-α), caspase-3, and caspase-8 in the serum and ileum, and destroyed the tight junction between epithelial cells. Intervention with Jinzhi reduced levels of serum LPS and tumor necrosis factor-α, and repaired the tight junction between epithelial cells. Furthermore, 16S rRNA gene sequencing analysis showed that treatment with Jinzhi improved the diversity and physiological function of the intestinal flora. Conclusions These results suggest that Jinzhi may be a promising option for the treatment of sepsis caused by LPS, and emphasize that Jinzhi exerts a recovery effect on the imbalance of intestinal flora.

This paper introduces a method for simultaneous detection of 2019 novel coronavirus (2019-nCoV) and influenza virus A and influenza virus B (FluA/B) by dual fluorescent RT-PCR, providing some references for the current clinical first-line practice against the epidemic. More than 12000 samples of nasopharyngeal swabs, sputum and anal swabs were collected. All samples were inactivated at 60°C for 40 min before testing, so as to protect medical examine. Nucleic acid detection kits from two manufacturers of 2019-nCoV and FluA/B were selected for the detection. Carboxyfluorescein (FAM) and green fluorescent protein (VIC) labeled probes were used to achieve simultaneous detection of the four gene targets using a double fluorescent RT-PCR reaction system. According to the results of nucleic acid detection, there is no cross infection between 2019-nCoV and FluA/B. The CT value of novel coronavirus nucleic acid in anal swab greater than CT value of sputum greater than CT value of nasopharyngeal swab in the same patient. This paper introduces a method for rapid and simultaneous detection of 2019-nCoV and FluA/B by dual fluorescent RT-PCR. It was improved the detection efficiency and reduce the cost, which could be used for rapid and emergent detection of 2019-nCoV and FluA/B. Our experiment is fast and accurate, could make reference for nucleic acid detection medical diagnosis for clinical medical staff.

To study the chemical constituents of Glycosmis pentaphylla.95% ethanolic extract of Glycosmis pentaphylla was fractioned and separated extensively by silica gel, Sephadex LH-20 chromatography,their structures were elucidated by means of spectral data analysis.All compounds were isolated and identified as 5,7,4’-trihydroxydihydroflavonol( 1),aromadendrin( 2),trans-dihydroquercetin( 3),cis-dihydroquercetin( 4),kaempferol( 5),quercetin( 6),5,7,4’-trihydroxyflavonol-3-O-α-L-rhamnopyranoside( 7),quercetin-3-O-α-L-arabinofuranoside( 8),quercetin-3-O-α-L-rhamnopyranoside( 9),5,7,3’,4’-tetrahydroxyflavonone-3-O-rhamnopyranoside( 1→6) glucopyranoside( 10) and 5,7,3’-trihydroxy-4’-methyl ether-flavonone-3-O-rhamnopyranoside( 1→6) glucopyranoside( 11).All compounds are isolated from this plant for the first time.

Bioactive natural products were firstly obtained from biogas slurry. Three new 29 carbon skeletons of the pentacyclic triterpenoid compounds 24-norolean-12-ene-3,22-dione (1), 3β-hydroxy-24-norolean-12-ene-22-one (2), 3α-hydroxy-24-norolean-12-ene-22-one (3), as well as one known compound S-equol (4) were isolated and purified from the MeOH extract of chicken manure biogas slurry. The molecular structures of the four compounds were elucidated based on the extensive spectroscopic data analysis, and the structure of Compound 1 was further confirmed by single-crystal X-ray diffraction. The structures of Compounds 1, 2, and 3 are similar with oleanolicum and hederagenin that has excellent anti-tumor activities. The cytotoxicity against five cancer cell lines (Hela, A549, MCF7, PC3, and B16) of Compounds 1–4 was tested. Similar to Compound 4 (S-equol), Compounds 1–3 (pentacyclic triterpenoids) showed cytotoxicity activity against different tumor cell lines. Compounds 1–3 showed slightly lower cytotoxicity activities than Compound 4. The IC50 of Compound 4 was determined to be 9.7–27.6 μM, while the IC50 values of 1–3 were 17.6–65.3 μM. There are no significant differences in the cytotoxicity capacities between Compounds 1, 2, and 3.

For the present situation of spotty mask fabrics in current market, the paper used natural fiber silk as raw materials for the study of anti-fog and haze mask fabrics. The paper design five different programs and any one sample in every program has different weft density or warp and weft yarn fabric specifications. Make total of 15 kinds of trial samples and do a series of testing of fabric performance. Through testing the pore size value, the filtration efficiency, resistance value and other indicators and analyzing the results, do research on filtering properties of the fabrics. The conclusions have certain guiding significance in product development.

The bulk viscosity is studied in a thermodynamically enhanced perturbative QCD (EPQ) model that includes the running of both the strong coupling and the strange quark mass. Similar to the results in other effective models, the bulk viscosity in the EPQ model is larger by 1--2 orders of magnitude compared with that in the MIT bag model. Comparison among the different models indicates that the similarity in orders is mainly due to the inclusion of interactions between quarks. When the temperature is relatively low and enters the equation of state of quark matter, the bulk viscosity can be enormously enlarged. For the analytical expression of bulk viscosity, a reasonable range of model parameters is found. Moreover, due to the enlarged bulk viscosity, the damping time of a strange star with about 2 times the solar mass can be as short as ${10}^{\ensuremath{-}3}$ second, showing that massive quark stars could reach stability quickly after some radial unstable activities.

Nonalcoholic fatty liver disease (NAFLD) has been reported to have effects on kidney diseases; however, a link between NAFLD and urinary calculi remains to be confirmed. This study was conducted on a male population based on our previous Fangchenggang Area Male Health and Examination Survey in Guangxi, China in order to estimate the frequency of urinary calculi and assess the association between NAFLD and urinary calculi while controlling for possible confounders.This was a population-based cross-sectional study conducted in the Fangchenggang region in Guangxi, China. The diagnoses of NAFLD and urinary calculi were made by ultrasonography. Clinical and laboratory findings were analyzed to investigate whether NAFLD was a risk factor for urinary calculi.A total of 3719 men were enrolled (age range, 17 to 88 years). Slightly more than a quarter (26.5%) of the participants were diagnosed with NAFLD. The percentage of urinary calculi in all participants was 6.9%, and the percentage of NAFLD patients with urinary calculi (8.4%) was significantly higher than that among patients without NAFLD (6.4%, P.05). Advanced age; high body mass index; elevated levels of blood glucose, cholesterol, triglycerides, and low-density lipoprotein cholesterol; low education; lower or higher physical activity; and NAFLD were independent risk factors for urinary calculi (P.05).Our results showed that NAFLD was associated with a higher incidence of urinary calculi in this cohort and NAFLD might represent a risk factor for urinary calculi.

Dralon superfine profiled acrylic interwoven with traditional spun silk .There are 9 kinds of interlaced fabric. We discussed that in same condition of finishing and fabric weave (3/1right twill),different picking shuttle between superfine profiled acrylic and spun silk have a impact on fabric performance of moisture absorption, air permeability, drape, crease recovery and warmth retention. The results showed that: fabric has better wearability when silk and acrylic picking proportion is 1:5(That is the content of acrylic is 61.16%).

The raw materials of blended yarns are Dralon superfine profiled acrylic, spun silk, Modal and cotton. Considering the different components and proportion, 6 kinds of woven fabrics were designed to test, then put to test and analysis the date of the heat retention, hygroscopicity, permeability, wrinkle resistance and drape performance. The results showed that,40S/1 acrylic / Modal (65/35) blended yarn can improve the warm of blended-spun-yarn fabric,40S/1 spun silk / acrylic / Modal (30/40/30) blended has a good quality of wrinkle resistance and permeability.40S/1 spun silk/ acrylic / cotton (20/50/30) blended can improve the drape performance and hygroscopicity of multi-component blended-spun-yarn fabric.

Machine learning is important solution in the research of Chinese text sentiment categorization , the text feature selection is critical to the classification performance. However, the classical feature selection methods have better effect on the global categories, but it misses many representative feature words of each category. This paper presents an improved information gain method that integrates word frequency and degree of feature word sentiment into traditional information gain methods. Experiments show that classifier improved by this method has better classification .

Based on chemical vapor deposition (CVD) reaction and numerical analysis of the transmission process, analysis the influence law of the process parameters has been conducted for silicon carbide thin film. A detailed analysis on impact of the chamber pressure, substrate temperature and inlet flow has been realized through the use of CFD and chemical reactions software, coupling fluid flow, chemical reactions and mass transfer process in the deposition of SiC thin film. The result of simulation fully proved that the process parameters have different influence law, especially the chamber pressure.

This paper discusses and compares the current development of the methods and techniques of embedded software testing. A compromised and practical embedded software testing method, which is between intervention and non-intervention, is proposed and the flow process is provided as well. The method has been verified by a real-case experiment and the result is satisfactory. Key words: Embedded software; testing method

Coverage testing is a basic method for dynamic software testing. Based on the basic block theory, an algorithm is proposed for calculating the branch routes of an embedded assembly program in software coverage testing. The correctness of the algorithm is verified on a sample assembly program and it’s time complexity is analyzed also.

In the paper, the surface modification of nanotitanium and its effect on the antibacterial properties of waterborne wood coating were studied. The effect of the type and amount of surfactant (system) and the ultrasonic treatment time on the property of nanotitanium and the effect of the dosage and adding method of nanoslurry on the properties of water-based wood coating were both investigated. The nanotitanium slurry made in the optimum conditions was also characterized. The results showed that nanotitanium slurry with excellent performance was obtained when 0.5wt% polyoxyethylene octylphenol ether and 3wt% sodium polyacrylate were used and ultrasonic treated 5h. It also showed that the waterborne wood coating with excellent drying performance and antibacterial property was got when 1.5wt % nanoslurry was mixed to water-based emulsion to hybrid. Under the conditions, the antibacterial rate against Escherichia coil and Staphlococcus aureus reaches to 95%.

In this study, a novel amphiphilic copolymer based on the flexible polydimethylsiloxane (PDMS) macroinitiator was successfully prepared by atom transfer radical polymerization (ATRP). First, the high molecular weight bis (hydroxyalkyl)-terminated PDMS was prepared by hydrosilation reaction between hydrogen-terminated PDMS and 2-allyloxyethanol in the presence of Karstedt’s catalyst. The macroinitiator Br-PDMS-Br was prepared by the reaction between different molecular weight bis (hydroxyalkyl)-terminated PDMS and 2-bromoisobutyry bromide. Then the amphiphilic ABA-type block copolymers of poly [dimethylsiloxane-b-(hydroxylethyl methacrylate)] were initiated by bromide end-capped PDMS with HEMA, under an appropriate catalyst/ligand system of CuCl/bpy. The polymerization proceeded with first-order kinetics. It showed that the reaction system was a controlled/‘living’ polymerization. The triblock copolymers were characterized by FTIR, 1H-NMR, TGA and GPC techniques. GPC results showed the tribolck copolymer had narrow polydispersity of Mw/Mn (PDI

Based on the unified solution of shear strength in terms of double stress state variables for unsaturated soils, the unified formula of stability coefficient for unsaturated soil slopes under the plane strain condition is derived by Sweden slice method, which considers the effect of the intermediate principal stress rationally. Combining with engineering example, the proposed formula is compared with the one that is on the basis of Fredlund unsaturated soil theory and the influencing characteristics of factors including intermediate principal stress, matric suction, effective internal friction angle and matric suction angle is obtained. The research result indicates that: intermediate principal stress and matric suction have obvious impacts on the stability coefficient for unsaturated soil slopes; the stability coefficient has been increasing with the increase of unified strength theory parameter and matric suction, which proves that the consideration of intermediate principal stress and matric suction can make slopes give full play to their self-stabilities and strength potential, and the yield criterion has great impact on the judgment of slope stability; the stability coefficient also increases nonlinearly with the increase of effective internal friction angle and matric suction angle. The proposed unified formula of stability coefficient for unsaturated soil slopes enjoys a wider application. The stability coefficient for unsaturated soil slopes according to the Fredlund unsaturated soil theory and that for saturated soil slopes are just the special cases. The research result can provide theoretical basis for stability analysis and reinforce design of the unsaturated soil slopes, and it is of great significance to the slope management.

This paper presented a high-speed image acquisition system based on PXI bus and Low Voltage Differential Signaling (LVDS) technology, with the characteristics of mass data, high-speed of data acquisition in the field of modem technology and scientific research. It expatiated the whole frame, and emphasized the design and implement of the system. It simulated the Ping-Pong operation of image data transmission, and tested the performance of the system. The results of test indicate that the high-speed image acquisition system has good ability of acquisition and transmission, and it can satisfy the engineering applied demand.

Based on unified strength theory, the mechanical behavior of core-concrete of concrete-filled square steel tubular stub columns was analyzed. Through controlling the constraint effect between square steel tube and core-concrete by width-thickness ratio, the ultimate bearing capacity formula for concrete-filled square steel tubular stub columns under axial compression was proposed, and the influencing factors of which was also discussed. The rationality of proposed formula was proved from the comparison of the analytical results obtained in this paper and experimental data.

To examine whether the predictive performance of prostate-specific antigen (PSA) and PSA-related markers for prostate cancer (PCa) is modified by body mass index (BMI). Patients with a PSA 2–10 ng/mL who underwent multicore prostate biopsies were recruited from three tertiary centers. Serum markers measured included total PSA (tPSA), free-to-total PSA (f/tPSA), p2PSA, percentage of p2PSA (%p2PSA) and prostate health index (PHI). The association between serum markers and PCa risk was assessed by logistic regression. Predictive performance for each marker was quantified using the area under the receiver operator curves (AUC). Among 516 men, 18.2% had PCa at biopsy. For all tested markers, their predictive value on PCa risk was lower in obese patients compared to normal weight patients. We found statistically significant interactions between BMI and tPSA (P = 0.0026) and p2PSA (P = 0.038). PHI achieved an AUC of 0.872 in normal weight patients and 0.745 in obese patients, which outperformed the other predictors regardless of BMI category. In conclusion, PHI achieved the best predictive performance for detecting PCa and was not influenced by BMI.

In this paper, based on planning practice, 3 cases at different levels are brought into probe the application of Value Engineering in urban planning practice; and strategies of constructing value chain in the practice are proposed and the future development of Value Engineering in planning are discussed and interpreted in time frame, space frame and discipline frame.

In order to confirm the different pharmaceuticals have different or similar effect, the paper put forward a new federation approach in analysis of pharmaceuticals. The first to data preprocessing using wavelet compression ,the second to classify for pharmaceuticals based on OPLS/O2PLS-DA. The result indicate that the different pharmaceuticals have different or similar effect ,The approach was proved to be feasible and effective after tested with 8 kinds of pharmaceuticals experimental data.

A series of starch-based styrene acrylate emulsion (SAE) modified with water-resistance agent were prepared by introducing rosin, organosilane(γ-amino propyl triethoxysilane (KH550), γ-(2,3-epoxypropoxy)-propytrimethoxysilane(KH560) and γ-methacryloxypropyl trimethoxy silane (KH570) as the functional monomer, respectively. In the reaction, starch(CS-8), which is low relative viscosity, was used as the emulsifier and dispersant. The optimum conditions of the reaction had especially been studied by orthogonal experiment and then the emulsion properties and surface sizing behaviors of the SAE modified with different kinds of water-resistance agents were compared. Finally, the products which had excellent properties were characterized and the sizing performance was investigated. The results showed that the excellent performance and good sizing effects of styrene acrylate emulsion (SAE) were achieved when the reaction conditions were as follows: rosin was selected as the water resistance-agent with the dosage of 2%(wt), the reaction temperature was 88°C, the mass ratio of St and BA was 9:11, the stirring speed was 130 round per minute and the dosage of initiator (APS), cationic monomer (DM) and CS-8 was 0.5%, 2%(wt) and 7%, respectively. The water-resistance properties of starch-based SAE were significantly improved by using rosin as the water-resistance agent and the surface sizing performance were better than that of the commercial AKD.

Polycrystalline tetragonal Y-ZrO2 fibres were fabricated via sol-gel technique by the centrifugal filament method using zirconium oxychloride octahydrate as the raw material. The spinnable zirconia sol was obtained by concentrating the solution, which the molar ratios of H2O2/ZOC and HA/ZOC were 3.0 and 0.5-1.0, respectively. FT-IR, TG/DTA, XRD and SEM were used to characterize the chemical composition and morphology of zirconia fibres. The bridging bidentate coordination between the carboxyl group and zirconium polymer can promote the spinnability of sols. The polycrystalline zirconia fibres structures are metastable tetragonal phase after heat treatment at 1200°C in 1h. The distribution of fibres is not uniform with a diameter from 5 μm to 10 μm. The single fibre has a uniform diameter and smooth surface, without any defect on the surfaces. The grain size of ZrO2 fibers increases with the heat treatment temperature gradually.

Polyethersulfone (PES) flat sheet membranes were prepared via phase inversion induced by immersion precipitation from a novel lower critical solution temperature (LCST) system containing PES, 1-butanol and N, N-dimethylacetamide. And the effect of coagulation bath temperature on the properties and structure of PES membranes were investigated. The results show that the pure water flux increases and the tensile strength decreases as the coagulation temperature increases form 20°C to 50°C. Besides, the SEM images shows that all of the membranes prepared from a LCST system at different CBT own sponge-like structures.

The planning theorem, concept and the related methodology in different era directly influenced the consequence of the city planning at that moment. They are the technical supports to realize the law of city planning. The sound interaction of city planning and city development is always one people are pursuing for. Whereas the city planning is the prerequisite of city development, and it needs corresponding planning theorem and approach to be its technical supports.

As the most common material, concrete shows one of the most essential beauty, with the natural appearance of calm charm, innate, some heavy and elegant modern building materials can not be replicated and comparable. Material itself has a soft feel, rigid sense of warmth, cold and flu, and not only the spirit of the human impact on the senses, and can express the emotion building. So architects believe that this is a noble simplicity, seems to be simple, in fact, more than the magnificent artistic effect.

The chemical composition of the essential oil of Mentha spicata from China was investigated by the Gas chromatography/mass spectrometry (GC/MS) analysis. 21 compounds were identified, representing 97.10% of the total oil. The major compounds in the essential oil were carvone (65.33%), limonene (18.19%), dihydrocarvone (2.97%) and camphene (2.34%). The oil showed antioxidant activity assessed using DPPH assay. The antimicrobial activity was investigated in order to evaluate its efficacy against 5 microorganisms using MIC and MBC methods. The results indicated that spearmint oil showed inhibitory and bactericidal effect on all test microorganisms. It was highly effective against E. coli, S. cerivisiae and P. citrinum. S. cerivisiae was more susceptible to spearmint oil (MIC 0.78125 uL/mL and MBC 6.25 uL/mL). The cytotoxicity of spearmint oil was evaluated on Hela cells using the MTT assay. The oil showed quite strong cytotoxicity on the cell lines with an IC50of about 2.08ug/mL.

The characteristics of stainless steel, notably its corrosion resistance, aesthetic appearance and mechanical properties, make it ideally suited for many architectural applications. Optimum performance is achieved by taking into account these characteristics when designing in stainless steel. The paper based on the idea of sustainable development analyses the outstanding features of stainless steel.

Based on the ecological civilization organic extension of ecological and spatial structure of urban space is a important method to form urban characters of a city. founded on the ecological character of the urban culture and the coherence of ecology,combined with evolutions of culture and proposes strategy for practical development and preservation. The organic extension of urban spatial structure is realized by combination mentioned and extractions of key nodes in the urban design.

Stainless steel develops in 21th century, which further extends its application in architectural industry and fields of structure. Based on the idea of sustainable development, this paper analyses the outstanding features that stainless steel possesses compared with other metal materials, trying to apply for a general outline for architect and those concerned. It examines the sustainability of the application of stainless steel, and matters needing attention in architectural design, and it prospects the outlook of stainless steel.

Me/MeN/Me (Me=Al, Ti ) multilayer thin films were deposited on silicon substrates by a multi-arc ion plating method (MAIP) and successive magnetron sputtering method (MS) respectively. The as-prepared and heat-treated films were characterized by scanning electron microscope (SEM) and auger electron spectra (AES). The results revealed that MS method has an advantage over MAIP method to prepare the Al/AlN/Ti submicron thin films which have high density, clear interface and smooth surface. In addition, the present study indicated that both the deposition sequence and mid-layer composition have a significant effect on the thermal stability. After heat-treatment at 500 oC for 10 min, the Al/AlN/Ti multilayer film prepared by the MS method has good thermal stability without surface crack or surface flaking. Furthermore, significant diffusion of oxygen element and nitrogen element within the multilayer interface was observed by the AES measurement. It is believed that the element diffusion in the multilayer interface plays an important role in the binding strength of multilayer interface.

Green city planning theory is the renovation and development of modern urban planning theory. It bases firmly on the ecologic philosophy and emphasize the dynamic harmony and organic unification of different factors. explore how to implement the Central Business District in urban planning for sustainable development.

This paper presents an authentication and key agreement mechanism for multi-domain wireless networks using bilinear pairings. Based on the computational Diffie-Hellman assumption and the random oracle model, we show that the proposed scheme is secure against an uncertified user and a malicious registration server simultaneously. As compared with the recently proposed schemes, our scheme enjoys less computational cost and has higher security level by exploiting the certificateless public key cryptography system. Moreover, our scheme can be used to mutual authentication and key agreement between members of distinct domains where all the servers use different system parameters. Efficiency analysis of related the security and computation overheads are given to demonstrate that our scheme is well suited for mobile devices with limited computing capability.

Polycrystalline alumina fibers were prepared by sol-gel method. The influence of heating rate on average tensile strength of fibers as well as the influence of calcining temperature on average tensile strength of fibers, crystal phases form, specific surface area of fibers were studied. The results show that when the heating rate (below 600°C) is 4°C/min,the average tensile strength of fibers over 1000Mpa The fibers pulverize obviously when the heating rate＞7°C/min. The average tensile strength and the specific surface area of fibers decreased with calcining temperature rising. When the calcining temperature reaches over 1300°C, the average tensile strength of fibers decreased quickly and the specific surface area of fibers decreases slowly for the crystalline growth.

A new 4WS vehicle model is set up by means of revamping a foreign FWS model. Co-simulation is completed by loading 4WS mechanical model as a subsystem which is built to express the characteristics of physical model of vehicle in ADAMS/Car into the control system modeled in MATLAB. Moreover, the response curves of evaluating handling stability are obtained according to co-simulation results of step steering maneuvers and single lane change maneuvers. It provides theoretical basis for developing 4WS physical vehicle rapidly.

Under the rapid development of urban modernization, old residential communities in big cities are facing the trends of disintegration of social relationships and crisis of community culture. By introducing the concept of " Cultural Route " which is a new type of world historical heritage in recent years, taking its implication of " cross-regional, historicity, culture, dynamic and linear " as use for reference, and applying it to research of old residential communities renewal which full with spatial characteristics of "island" and "marginalized", this paper attempts to make use of concept “Cultural Route" to find local historical cultural resources in Yuzhong district, city center of Chongqing, and to form the “City Cultural Route" with properties of local life and urban tourism. The paper uses the way of case study, site survey, data analysis and finally concludes a new method to revive existing old communities in Chongqing.

It's one of the important management job of each university currently that discovering and monitoring the public network opinion in the campus.This article describes some of the major basic research of the university network public opinion discovering and monitoring system .First and foremost,this paper studies the method of capture packets on the outlet of campus network using Libnids network security development kit.Second,the contents of HTTP, POP3 and STMP packets are separately analyzed . Finally, The data obtained from the above steps provide the ideal data preparation. for the the university network public opinion discovering and monitoring system .

A series of core-shell type cationic soap-free latex were prepared by using styrene(St), butyl acrylate(BA) and methyl methacrylate(MMA) as main materials and introducing rosin as the functional monomer. In this reaction, starch(CS-8), which has low relative viscosity , was used as the emulsifier and dispersant. The influencing factors of the reaction were especially studied and the optimum conditions were got. Then the products were characterized by using scanning electron microscope (SEM), FT-IR, laser particle sizer, particle charge detector(PCD). The results show that the excellent performance and good sizing effects of SAE are achieved when the reaction conditions are as follows: the starch amount is 8%(wt), the charge for the initiator(APS) is 0.5%, and the amount of rosin is 2%(wt). And the water-resistant performance of paper is improved significantly when the rosin is chosen as the functional monomer.

We study the strange quark mass effect on the phase diagram of strong interaction and the structure of compact stars with a thermodynamically enhanced perturbative QCD model by matching quark matter onto nuclear matter using the Gibbs conditions. It is found that the mass effect of strange quark matter can obviously stiffen the equation of state of mixed phases and result in more massive hybrid stars (HSs), while that usually lowers the maximum mass of pure quark stars. Given reasonable model parameters, the maximum mass of HSs can reach two times the solar mass and the stars always have mixed-phase core in a considerably wide range of model parameters.

This study aimed to evaluate the clinical efficacy of different target volumes in pelvic radiotherapy in postoperative treatment of cervical cancer based on the Sedlis criteria.Patients who admitted to our department for post-operative radiotherapy of cervical cancer from December 2001 to December 2011 and met the Sedlis criteria were retrospectively analysed. The incidences of acute and late radiation injuries, and overall, disease-free and tumour-specific survival with reduced-volume pelvic and whole-pelvis radiotherapy were evaluated and compared.A total of 371 patients were included in the study, including 239 receiving whole-pelvis radiotherapy and 132 receiving reduced-volume pelvic radiotherapy. The volume of contours for mean PTV volumes, bilateral femoral heads and small intestine volumes in reduced-volume pelvic radiotherapy were lower than whole-pelvis radiotherapy; the results were similar to the V10, V20, V30, V40 and V45 for pelvic bone marrow and small intestine dose volume (both p0.05). The acute radiation injury observed in the two groups was mainly haematologic toxicity and upper and lower gastrointestinal symptoms. The incidences of acute radiation injury, and late radiation injury of gastrointestinal and urinary tracts were both significantly lower with reduced-volume pelvic radiotherapy than with whole-pelvis radiotherapy (both p0.05). Moreover, there was no significant difference in the incidence of lower extremity oedema, or 2-year or 5-year overall, disease-free or tumour-specific survival between groups (all p0.05).Reduced-volume pelvic radiotherapy could relieve acute and late radiation injuries, especially myelosuppression, and did not affect long-term survival. Advanced in knowledge: Our study shows that reduced-volume base on National Comprehensive Cancer Network 2016 is more fit for cervical cancer than others.

How to define a clinical target volume (CTV) as small as possible for prostate cancer to reduce the dose received by normal organs is an interesting study. We conduct a research to analyze the clinical efficacy of intensity modulated radiotherapy (IMRT) using reduced CTV in the treatment of prostate cancer. From January 2006 to June 2010, 78 patients with prostate cancer were treated with IMRT according to this institutional protocol. Of them, 18 had stage II tumors, 39 had stage III tumors, and 21 had stage IVa tumors. Clinical outcomes included overall survival, biochemical recurrence, recurrence-free survival, and acute and chronic injuries caused by radiotherapy. Risk factors were evaluated using the Cox regression model. As of December 31, 2014, all patients completed radiotherapy as planned. Myelosuppression was mostly grade 1, acute urinary injury was mostly grades 1 and 2, and intestinal injury was mostly grade 1. The 5-year follow-up rate was 91.0%. The overall, progression-free, biochemical recurrence-free, and distant metastasis-free survival rates were 82.1%, 79.4%, 84.6%, and 94.9%, respectively. Tumor volumes defined by small target volumes and Radiation Therapy Oncology Group were 274.21 ± 92.64 and 600.68 ± 113.72, respectively, representing a significant difference (P

A versatile combinatorial approach was developed for the rapid synthesis of 2,5-dihydro-1H-pyrroles, 1,3-dioxo-2,3,5,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazoles, and 1,4-dioxo-1,2,3,4,6,8a-hexahydropyrrolo[1,2-a]pyrazines libraries. The synthetic strategy includes electrophilic addition, dehydrohalogenation, 1,3-dipolar cycloaddition, N-acylation, amino carbonylation-cyclization, N-alkylation, lactamization, and oxidation-elimination.

A new testing method for analog circuit is proposed in this paper. A low-pass Butterworth filter is taken as the typical system under test (SUT) since the analog circuits in different types of electronic systems can be regarded as the low-, band- or high-pass active (passive) filters. The chaotic signal, which is generated by an improved Chua's circuit, is employed as the excitation signal of SUT. The SUT is a “narrowband” system compared with the bandwidth of input signal, whose state is analyzed with an error-tracking approach. The experimental result depicts that this testing method can efficiently detect the change of the circuit parameter. Besides, another eight features are extracted from the output signal of SUT for analyzing the SUT states. A discussion is made for comparing the effectiveness of each feature according to the testing results.

In adults, angiogenic abnormalities are involved in not only tumor growth but several human inherited diseases as well. It is unclear, however, concerning how the normal vascular structure is maintained and how angiogenesis is initiated in normal adults. Using the Cre-LoxP-mediated conditional gene deletion, we show in the present study that in adult mice disruption of the transcription factor recombination signal-binding protein Jkappa (RBP-J) in endothelial cells strikingly induced spontaneous angiogenesis in multiple tissues, including retina and cornea, as well as in internal organs, such as liver and lung. In a choroidal neovascularization model, which mimics the angiogenic process in tumor growth and age-related macular degeneration, RBP-J deficiency induced a more intensive angiogenic response to injury. This could be transmitted by bone marrow, indicating that RBP-J could modulate bone marrow-derived endothelial progenitor cells in adult angiogenesis. In addition, in the absence of RBP-J, proliferation of endothelial cells increased significantly, leading to accumulative vessel outgrowth. These findings suggest that in adults RBP-J-mediated Notch signaling may play an essential role in the maintenance of vascular homeostasis by repressing endothelial cell proliferation.

The aims of this study were to investigate the inhibitory efficacy of intravitreal dexamethasone acetate (DA)-loaded by (D, L-lactide-co-glycolide) (PLGA) nanoparticles on choroidal neovascularization (CNV) in a laser-induced rat model and to evaluate its mode of drug release.DA loaded with PLGA nanoparticles containing 50% DA was prepared using an emulsification/solvent evaporation method. CNV was unilaterally induced by laser photocoagulation in rats. Different dosages of sterilized DA-loaded PLGA nanoparticles suspensions by intravitreal injection were evaluated (i.e., 50, 100, 200, and 400 mug) and the blank PLGA vehicle was the control. The concentration of DA in vitreous was measured by reverse-phase high-performance liquid chromatography (RP-HPLC). Flash electroretinography and transmission electron microscopy were performed to assess retinal toxicity. Fluorescein fundus angiography was performed to evaluate the incidence of CNV on days 14 and 56. The animals were sacrificed on day 56, then eyecups were processed for histologic analysis.The in vitro release of DA from nanoparticles showed that 50% of the drug was released over 2 weeks and controlled release in a linear pattern for 40 days. The pharmacokinetics of DA-loaded PLGA nanoparticles in the eyes with CNV demonstrated a triphasic pattern. The DA concentrations in vitreous remained within the effective range, which is capable of inhibiting inflammatory responses for more than 56 days. On day 14 after photocoagulation, the incidence of CNV was 47.4% as for 50 microg, 28.2% for 100 microg, 15.8% for 200 microg and 7.9% for the 400 microg DA-loaded PLGA nanoparticles group, respectively, and 65.8% for the control. On day 56, The inhibition of DA-loaded PLGA nanoparticles on CNV showed a dose-dependent effect. No sign of retinal toxicity was detected.These results suggest that DA-loaded PLGA nanoparticles can dose-dependently inhibit the development of experimental CNV. The controlled intraocular delivery system of DA-loaded PLGA nanoparticles may be a potentiality for CNV treatment.

Angiogenesis, the formation of new blood vessels that is regulated by hypoxia, is a critical process for the growth and spread of tumors. Multiple phases of this process, including migration, adhesion, and formation of new capillary tubes, are needed for optimal tumor growth. Here, a new regulatory function for Ca2+-CaM in the vascular endothelium is described. Ca2+-CaM activation induced by hypoxia in endothelial cells is essential for angiogenic cellular responses. Inhibition of Ca2+-CaM activity suppressed endothelial cell migration, adhesion on collagen I substrate, invasion and impaired in vitro endothelial cell differentiation into tube-like structures. We also reported that CaM is co-distributed with the actin structures in the lamellipodia in migrating cells, whereas the actin cytoskeleton rearrangement induced by hypoxia was disrupted and HIF-1 transcriptional activity was decreased when treated with CaM antagonists into cultures. These data indicate that Ca2+-CaM activation is more closely associated with the regulation of angiogenic key events, especially in response to hypoxic stress.

Herein, we aimed to examine whether the association of body mass index (BMI) with prostate cancer (PCa) at biopsy differs according to genetic susceptibility. In a multicenter prospective cohort including 1120 men undergoing diagnostic prostate biopsy in China, we evaluated the interaction between BMI and genetic risk score (GRS) comprising 24 PCa-associated single nucleotide polymorphisms (SNPs), as well as a GRS consisting of 7 SNPs derived from an East-Asian population. The genetic risk was defined as low, intermediate, or high when GRS fell in the first, second, and third tertiles, respectively. We observed a significant interaction between BMI and PCa GRS (Pinteraction = 0.047), suggesting that the predictive value of BMI on PCa was strongly modified by genetic susceptibility. In men with high genetic risk, BMI was an independent predictor of PCa (odds ratio [OR] = 1.167, P = 0.008) after adjusting for conventional risk factors. The relationship between BMI and PCa risk diminished (P = 0.990) in men with low genetic risk. The interaction was more pronounced with the East-Asian GRS (Pinteraction = 0.032), suggesting that the overall GRS interaction most likely occurs through genetic susceptibility in the East-Asian population. Our results suggest that the predictive effect of BMI on the PCa risk is strongly modified by individual genetic susceptibility. The association is more positive among men with high genetic risk for PCa.