75 results on '"Jevtovic, Djordje"'
Search Results
52. Lipodystrophy induced by combination antiretroviral therapy in HIV/AIDS patients: A Belgrade cohort study
- Author
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Dragovic, Gordana, primary, Danilovic, Dragana, additional, Dimic, Aleksandra, additional, and Jevtovic, Djordje, additional
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- 2014
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53. Trastuzumab resistance: Bringing tailored therapy to the clinic
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Bannister, Wendy, Ruiz, Lidia, Cozzi-Lepri, Alessandro, Mocroft, Amanda, Kirk, Ole, Staszewski, Schlomo, Loveday, Clive, Karlsson, Anders, d'Arminio Monforte, Antonella, Clotet, Bonaventura, Lundgren, Jens D, Losso, Marcello, Durand, Arnaud, Vetter, Norbert, Karpov, Igor, Vassilenko, A., Clumeck, Nathan, Dewit, Suzanne, Poll, Bénédicte, Colebunders, Robert Leon, Kostov, Kostadin, Begovac, Josip, Ristola, Matti, Machala, Ladislav, Rozsypal, Hanuš, Sedlacek, Dalibor, Nielsen, Jorgen E, Benfield, Thomas, Gerstoft, Jan, Katzenstein, Terese Lea, Hansen, Annette Brit Eg, Skinhøj, Peter, Pedersen, Court, Oestergaard, Lone Lange, Zilmer, Kai, Smidt, Jelena, Katlama, Christine, Viard, Jean-Paul, Girard, Pierre Marie, Livrozet, Jean-Michel, Vanhems, Philippe, Pradier, Christian, Dabis, François, Rockstroh, Jürgen, Schmidt, Rüdiger, Van Lunzen, Jan, Degen, Olaf, Stellbrink, Hans-Jurgen, Bogner, Johannes, Fätkenheuer, Gerd, Kosmidis, John, Gargalianos, Panagiotis, Xylomenos, George, Perdios, J., Panos, George, Filandras, A., Karabatsaki, E., Sambattakou, H., Banhegyi, Dénes, Mulcahy, Fiona, Yust, Israel, Turner, Dan, Burke, Michael, Pollack, Simeon, Hassoun, Gamal, Maayan, Shlomo, Chiesi, Antonio, Esposito, Roberto, Mazeu, I., Mussini, Cirillo, Arici, Claudio, Pristera, Raffaele, Mazzotta, Francesco, Gabbuti, Andrea, Vullo, Vincenzo, Lichtner, Miriam, Chirianni, Antonio, Montesarchio, Enzo, Gargiulo, Miriam, Antonucci, Giorgio, Iacomi, Fabio, Narciso, Pasquale, Vlassi, Chrysoula, Zaccarelli, Mauro, Lazzarin, Adriano, Finazzi, Renato, Galli, Mara, Ridolfo, Anna Lisa, Rozentale, Baiba, Aldins, Pauls, Chaplinskas, Saulius, Hemmer, Robert, Staub, Thérèse, Reiss, Peter, Bruun, Johan, Maeland, Arild, Ormaasen, Vidar, Knysz, Brygida, Gasiorowski, Jacek, Horban, Andrzej, Prokopowicz, Danuta, Wiercinska-Drapalo, A., Boron-Kaczmarska, Anna, Pynka, Magdalena, Beniowski, Marek, Mularska, Elzbieta, Trocha, Hanna, Antunes, Francisco, Valadas, Emília, Mansinho, Kamal, Maltez, Fernando, Duiculescu, Dan, Rakhmanova, Aza, Vinogradova, E., Buzunova, S., Jevtovic, Djordje, Mokráš, Miloš, Staneková, Danica, Gonzalez-Lahoz, Juan, Soriano, V., Martin-Carbonero, L., Labarga, P., Jou, A., Conejero, J., Tural, C., Gatell, J.M., Miró, José María, Domingo, Perre, Gutierrez, Maria, Mateo, V, Sambeat, María Antònia, Karlsson, Annika, Persson, P.O., Flamholc, Leo, Ledergerber, Bruno, Weber, R., Francioli, Patrick, Cavassini, Matthias, Hirschel, Bernard, Boffi, Emmanuelle, Furrer, Hansjakob, Battegay, Manuel, Elzi, Luigia, Kravchenko, É V., Chentsova, Nelly, Barton, Simon E.Simon, Johnson, Antoinette, Mercey, Danielle, Phillips, Adam, Johnson, Margaret, Murphy, M., Weber, J., Scullard, George, Fisher, Martin, Brettle, R., Antunes, F., Gatell, Jose, Gazzard, Brian George, Ledergerber, B., Reiss, P., Friis-Møller, Nina, Cozzi-Lepri, A., Bannister, W., Ellefson, M., Borch, A., Podlevkareva, D., Holkmann Olsen, C., Kjar, J., Petersen, Lars, Reekie, J., Bannister, Wendy, Ruiz, Lidia, Cozzi-Lepri, Alessandro, Mocroft, Amanda, Kirk, Ole, Staszewski, Schlomo, Loveday, Clive, Karlsson, Anders, d'Arminio Monforte, Antonella, Clotet, Bonaventura, Lundgren, Jens D, Losso, Marcello, Durand, Arnaud, Vetter, Norbert, Karpov, Igor, Vassilenko, A., Clumeck, Nathan, Dewit, Suzanne, Poll, Bénédicte, Colebunders, Robert Leon, Kostov, Kostadin, Begovac, Josip, Ristola, Matti, Machala, Ladislav, Rozsypal, Hanuš, Sedlacek, Dalibor, Nielsen, Jorgen E, Benfield, Thomas, Gerstoft, Jan, Katzenstein, Terese Lea, Hansen, Annette Brit Eg, Skinhøj, Peter, Pedersen, Court, Oestergaard, Lone Lange, Zilmer, Kai, Smidt, Jelena, Katlama, Christine, Viard, Jean-Paul, Girard, Pierre Marie, Livrozet, Jean-Michel, Vanhems, Philippe, Pradier, Christian, Dabis, François, Rockstroh, Jürgen, Schmidt, Rüdiger, Van Lunzen, Jan, Degen, Olaf, Stellbrink, Hans-Jurgen, Bogner, Johannes, Fätkenheuer, Gerd, Kosmidis, John, Gargalianos, Panagiotis, Xylomenos, George, Perdios, J., Panos, George, Filandras, A., Karabatsaki, E., Sambattakou, H., Banhegyi, Dénes, Mulcahy, Fiona, Yust, Israel, Turner, Dan, Burke, Michael, Pollack, Simeon, Hassoun, Gamal, Maayan, Shlomo, Chiesi, Antonio, Esposito, Roberto, Mazeu, I., Mussini, Cirillo, Arici, Claudio, Pristera, Raffaele, Mazzotta, Francesco, Gabbuti, Andrea, Vullo, Vincenzo, Lichtner, Miriam, Chirianni, Antonio, Montesarchio, Enzo, Gargiulo, Miriam, Antonucci, Giorgio, Iacomi, Fabio, Narciso, Pasquale, Vlassi, Chrysoula, Zaccarelli, Mauro, Lazzarin, Adriano, Finazzi, Renato, Galli, Mara, Ridolfo, Anna Lisa, Rozentale, Baiba, Aldins, Pauls, Chaplinskas, Saulius, Hemmer, Robert, Staub, Thérèse, Reiss, Peter, Bruun, Johan, Maeland, Arild, Ormaasen, Vidar, Knysz, Brygida, Gasiorowski, Jacek, Horban, Andrzej, Prokopowicz, Danuta, Wiercinska-Drapalo, A., Boron-Kaczmarska, Anna, Pynka, Magdalena, Beniowski, Marek, Mularska, Elzbieta, Trocha, Hanna, Antunes, Francisco, Valadas, Emília, Mansinho, Kamal, Maltez, Fernando, Duiculescu, Dan, Rakhmanova, Aza, Vinogradova, E., Buzunova, S., Jevtovic, Djordje, Mokráš, Miloš, Staneková, Danica, Gonzalez-Lahoz, Juan, Soriano, V., Martin-Carbonero, L., Labarga, P., Jou, A., Conejero, J., Tural, C., Gatell, J.M., Miró, José María, Domingo, Perre, Gutierrez, Maria, Mateo, V, Sambeat, María Antònia, Karlsson, Annika, Persson, P.O., Flamholc, Leo, Ledergerber, Bruno, Weber, R., Francioli, Patrick, Cavassini, Matthias, Hirschel, Bernard, Boffi, Emmanuelle, Furrer, Hansjakob, Battegay, Manuel, Elzi, Luigia, Kravchenko, É V., Chentsova, Nelly, Barton, Simon E.Simon, Johnson, Antoinette, Mercey, Danielle, Phillips, Adam, Johnson, Margaret, Murphy, M., Weber, J., Scullard, George, Fisher, Martin, Brettle, R., Antunes, F., Gatell, Jose, Gazzard, Brian George, Ledergerber, B., Reiss, P., Friis-Møller, Nina, Cozzi-Lepri, A., Bannister, W., Ellefson, M., Borch, A., Podlevkareva, D., Holkmann Olsen, C., Kjar, J., Petersen, Lars, and Reekie, J.
- Abstract
SCOPUS: re.j, info:eu-repo/semantics/published
- Published
- 2008
54. Distribution of JC virus genotypes among serbian patients infected with HIV and in healthy donors
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Karalic, Danijela, primary, Lazarevic, Ivana, additional, Knezevic, Aleksandra, additional, Cupic, Maja, additional, Jevtovic, Djordje, additional, and Jovanovic, Tanja, additional
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- 2013
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55. Molecular typing of the local HIV-1 epidemic in Serbia
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Siljic, Marina, primary, Salemovic, Dubravka, additional, Jevtovic, Djordje, additional, Pesic-Pavlovic, Ivana, additional, Zerjav, Sonja, additional, Nikolic, Valentina, additional, Ranin, Jovan, additional, and Stanojevic, Maja, additional
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- 2013
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56. The significance of hepatitis B virus (HBV) genotypes for the disease and treatment outcome among patients with chronic hepatitis B in Serbia
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Milosevic, Ivana, primary, Delic, Dragan, additional, Lazarevic, Ivana, additional, Pavlovic, Ivana Pesic, additional, Korac, Milos, additional, Bojovic, Ksenija, additional, and Jevtovic, Djordje, additional
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- 2013
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57. Non-specific inflammatory parameters in patients with pandemic H1N1 influenza
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Milosevic, Ivana, primary, Korac, Milos, additional, Zerjav, Sonja, additional, Urosevic, Aleksandar, additional, Lavadinovic, Lidija, additional, Milosevic, Branko, additional, and Jevtovic, Djordje, additional
- Published
- 2013
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58. The role of nucleoside reverse transcriptase inhibitors usage in the incidence of hyperlactatemia and lactic acidosis in HIV/AIDS patients
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Dragovic, Gordana, primary and Jevtovic, Djordje, additional
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- 2012
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59. Pharmacogenetics of antiretroviral drugs
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Dragovic, Gordana, primary, Grbovic, Leposava, additional, and Jevtovic, Djordje, additional
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- 2012
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60. Safety of antiretrovirals in pregnacy
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Dragovic, Gordana, primary, Grbovic, Leposava, additional, Jevtovic, Djordje, additional, Andjelic, Spaso, additional, Vasic, Bojan, additional, and Lukic, Relja, additional
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- 2011
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61. Postexposure prophylaxis against hepatitis B, hepatitis C and human immunodeficiency virus infection in healthcare workers
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Vasic, Bojan, primary, Andjelic, Spaso, additional, Lukic, Relja, additional, Jevtovic, Djordje, additional, Grbovic, Leposava, additional, Vasiljevic, Tatjana, additional, and Dragovic, Gordana, additional
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- 2011
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62. The Prognosis of Late Presenters in the Era of Highly Active Antiretroviral Therapy in Serbia
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Jevtovic, Djordje, primary, Salemovic, Dubravka, additional, Ranin, Jovan, additional, Brmbolic, Branko, additional, Pesic-Pavlovic, Ivana, additional, Zerjav, Sonja, additional, and Djurkovic-Djakovic, Olgica, additional
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- 2009
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63. The Prognosis of Pediatric AIDS in Serbia
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Jevtovic, Djordje, primary, Salemovic, Dubravka, additional, Ranin, Jovan, additional, Brmbolic, Branko, additional, and Djurkovic-Djakovic, Olgica, additional
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- 2009
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64. Immune recovery vitritis
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Dujic, Mirjana, primary and Jevtovic, Djordje, additional
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- 2007
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65. Herpes simplex virus resistance to acyclovir in routine virological laboratory practice
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Stanojevic, Maja, primary, Zerjav, Sonja, additional, Jevtovic, Djordje, additional, and Jovanovic, Tanja, additional
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- 2005
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66. Nucleoside Reverse Transcriptase Inhibitor Usage and the Incidence of Peripheral Neuropathy in HIV/AIDS Patients
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Dragovic, Gordana, primary and Jevtovic, Djordje, additional
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- 2003
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67. HIV-1 Subtypes in Yugoslavia
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Stanojevic, Maja, primary, Papa, Anna, additional, Papadimitriou, Evagelia, additional, Zerjav, Sonja, additional, Jevtovic, Djordje, additional, Salemovic, Dubravka, additional, Jovanovic, Tanja, additional, and Antoniadis, Antonis, additional
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- 2002
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68. Distribution of JC virus genotypes among serbian patients infected with HIV and in healthy donors.
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Karalic, Danijela, Lazarevic, Ivana, Knezevic, Aleksandra, Cupic, Maja, Jevtovic, Djordje, and Jovanovic, Tanja
- Abstract
Certain factors lead to increased reactivation of JC virus (JCV) and immunodeficiency seems to be the most important. JCV isolates can be classified into eight different genotypes and several subtypes based on nucleotide difference in the VP1 gene. JCV genotypes are strongly associated with particular ethnic groups and frequently used as genetic markers for human evolution and migration. The aim of this study was to determine the frequency of JCV urinary shedding and genotype distribution in Serbia among patients infected with HIV and healthy donors. Urine samples from 107 healthy donors and 93 patients infected with HIV were collected. PCR followed by sequence analysis was carried out using primers specific for VP1 and NCRR of the virus genome. Excretion rate of JCV-DNA in urine was higher in patients infected with HIV than in healthy donors (44.1% vs. 31.7%) although statistical significance was not found. Within the group infected with HIV, the degree of immunosuppression (measured by CD4
+ cell count) did not influence JCV excretion rate. Sequence analysis of JCV NCRR from both patients infected with HIV and healthy donors showed a pattern identical to archetype structure. In healthy Serbian donors the predominant genotype was 1 (41.2%), followed by 4 (32.4%) and 2 (26.4%). On the other hand, genotype distribution pattern was different in patients infected with HIV: 2 (43.9%), 1 (31.7%), and 4 (24.4%). This study showed that European, Eurasian, and Indian types are circulating in Serbia and that distribution corresponds to the origin of the inhabitants of Serbia. J. Med. Virol. 86:411-418, 2014. © 2013 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]- Published
- 2014
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69. CYP2B6516G>T (rs3745274) and Smoking Status Are Associated With Efavirenz Plasma Concentration in a Serbian Cohort of HIV Patients
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Olagunju, Adeniyi, Siccardi, Marco, Amara, Alieu, Jevtovic, Djordje, Kusic, Jovana, Owen, Andrew, and Dragovic, Gordana
- Abstract
Genetic factors have been associated with efavirenz (EFV) plasma concentrations in different populations. In this study, we investigated the effects of CYP2B6516G>T (rs3745274), CYP2B6c.485-18C>T (rs4803419), CARc.540C>T (rs2307424), CARc.152-1089T>C (rs3003596), and smoking status in a cohort of Serbian patients with HIV.
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- 2014
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70. Risk for toxoplasmic encephalitis in AIDS patients in Yugoslavia
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Djurković-Djaković, Olgica, Bobić, Branko, Vuković, Dragana, Marinković, Jelena, and Jevtović, Djordje
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- 1997
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71. Immuno-virological discordance and the risk of non-AIDS and AIDS events in a large observational cohort of HIV-patients in Europe
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Anne Johnson, Adriano LAZZARIN, Robert Flisiak, Jens Lundgren, Nicola Gianotti, Clifford Leen, Vicente Soriano, Linos Vandekerckhove, Matti Ristola, STEFANO VELLA, Lars Østergaard, Đorđe Jevtović, Thomas Benfield, Viktar M. Mitsura, Terese L Katzenstein, Antonella Castagna, Anna Grzeszczuk, Vassilenko Anna, Robert Colebunders, Universitat de Barcelona, Amsterdam institute for Infection and Immunity, Amsterdam Public Health, Global Health, Zoufaly, Alexander, Cozzi lepri, Alessandro, Reekie, Joanne, Kirk, Ole, Lundgren, Jen, Reiss, Peter, Jevtovic, Djordje, Machala, Ladislav, Zangerle, Robert, Mocroft, Amanda, Van Lunzen, Jan, Eurosida In, Eurocoord, and Castagna, Antonella
- Subjects
Male ,HIV opportunistic infections ,HIV Infections ,Disease ,0302 clinical medicine ,CLINICAL-TRIALS GROUP ,Prospective Studies ,Young adult ,lcsh:Science ,Aged, 80 and over ,0303 health sciences ,IMMUNODEFICIENCY ,Antiretrovirals ,3. Good health ,Anti-Retroviral Agents ,HIV epidemiology ,Cohort ,Regression Analysis ,Medicine ,Infectious diseases ,Viral load ,Human ,medicine.medical_specialty ,03 medical and health sciences ,Humans ,Immune response ,Aged ,Biochemistry, Genetics and Molecular Biology (all) ,CD4 CELL COUNT ,030306 microbiology ,MORTALITY ,lcsh:R ,Immunity ,medicine.disease ,Prospective Studie ,Morbiditat ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,Agricultural and Biological Sciences (all) ,Immunology ,HIV-1 ,Kidney Failure, Chronic ,lcsh:Q ,Morbidity ,RESPONSES ,lcsh:Medicine ,PROGRESSION ,Kaplan-Meier Estimate ,Cohort Studies ,Liver disease ,Resposta immunitària ,Risk Factors ,Neoplasms ,Outcome Assessment, Health Care ,Medicine and Health Sciences ,HIV Infection ,030212 general & internal medicine ,Prospective cohort study ,Multivariate Analysi ,INFECTED PATIENTS ,Multidisciplinary ,Medicine (all) ,HIV diagnosis and management ,Middle Aged ,Viral Load ,Host-Pathogen Interaction ,Europe ,Host-Pathogen Interactions ,symbols ,Observational Studies ,Female ,HIV clinical manifestations ,Research Article ,Adult ,Clinical Research Design ,Viral diseases ,Immune Suppression ,Regression Analysi ,symbols.namesake ,Outcome Assessment (Health Care) ,Young Adult ,Acquired immunodeficiency syndrome (AIDS) ,Internal medicine ,DEFINING MALIGNANCIES ,medicine ,VIH (Virus) ,Poisson regression ,COMBINATION ANTIRETROVIRAL THERAPY ,SUPPRESSION ,Acquired Immunodeficiency Syndrome ,Immunosupressió ,business.industry ,HIV (Viruses) ,Risk Factor ,HIV ,Antiretroviral agents ,CD4 Lymphocyte Count ,Multivariate Analysis ,Neoplasm ,Anti-Retroviral Agent ,Clinical Immunology ,business ,Immunosuppression - Abstract
Contains fulltext : 135923.pdf (Publisher’s version ) (Open Access) BACKGROUND: The impact of immunosuppression despite virological suppression (immuno-virological discordance, ID) on the risk of developing fatal and non-fatal AIDS/non-AIDS events is unclear and remains to be elucidated. METHODS: Patients in EuroSIDA starting at least 1 new antiretroviral drug with CD4500 copies/mL were followed-up from the first day of VL< = 50 copies/ml until a new fatal/non-fatal non-AIDS/AIDS event. Considered non-AIDS events included non-AIDS malignancies, pancreatitis, severe liver disease with hepatic encephalopathy (>grade 3), cardio- and cerebrovascular events, and end-stage renal disease. Patients were classified over time according to whether current CD4 count was above (non-ID) or below (ID) baseline level. Relative rates (RR) of events were calculated for ID vs. non-ID using adjusted Poisson regression models. RESULTS: 2,913 patients contributed 11,491 person-years for the analysis of non-AIDS. 241 pre-specified non-AIDS events (including 84 deaths) and 89 AIDS events (including 10 deaths) occurred. The RR of developing pre-specified non-AIDS events for ID vs. non-ID was 1.96 (95% CI 1.37-2.81, p
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- 2014
72. CD4 cell count and viral load-specific rates of AIDS, non-AIDS and deaths according to current antiretroviral use
- Author
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Amanda Mocroft, Phillips, Andrew N., Jose Gatell, Andrej Horban, Bruno Ledergerber, Kai Zilmer, Djordje Jevtovic, Fernando Maltez, Daria Podlekareva, Lundgren, Jens D., The EuroSIDA Study in EuroCOORD, Matti Ristola, University of Zurich, Mocroft, Amanda, Phillips, Andrew N., Gatell, Jose, Horban, Andrej, Ledergerber, Bruno, Zilmer, Kai, Jevtovic, Djordje, Maltez, Fernando, Podlekareva, Daria, Lundgren, Jens D, Eurosida Study In, Eurocoord, Castagna, Antonella, Amsterdam institute for Infection and Immunity, Amsterdam Public Health, and Global Health
- Subjects
Male ,CD4 cell count ,Rate ratio ,Cohort Studies ,10234 Clinic for Infectious Diseases ,chemistry.chemical_compound ,0302 clinical medicine ,Abacavir ,Immunology and Allergy ,Prospective Studies ,030212 general & internal medicine ,0303 health sciences ,Incidence ,Incidence (epidemiology) ,Lamivudine ,Middle Aged ,Viral Load ,3. Good health ,AIDS ,Death ,Infectious Diseases ,Anti-Retroviral Agents ,2723 Immunology and Allergy ,Female ,Survival Analysi ,Poverty-related infectious diseases Infectious diseases and international health [N4i 3] ,Viral load ,Human ,medicine.drug ,Combination antiretroviral therapy ,Adult ,medicine.medical_specialty ,Efavirenz ,Immunology ,610 Medicine & health ,Non-AIDS ,03 medical and health sciences ,Zidovudine ,Internal medicine ,medicine ,Humans ,Acquired Immunodeficiency Syndrome ,2403 Immunology ,030306 microbiology ,business.industry ,2725 Infectious Diseases ,Survival Analysis ,CD4 Lymphocyte Count ,Atazanavir ,Prospective Studie ,chemistry ,Anti-Retroviral Agent ,Cohort Studie ,business - Abstract
Background: CD4 cell count and viral loads are used in clinical trials as surrogate endpoints for assessing efficacy of newly available antiretrovirals. If antiretrovirals act through other pathways or increase the risk of disease this would not be identified prior to licensing. The aim of this study was to investigate the CD4 cell count and viral load-specific rates of fatal and nonfatal AIDS and non-AIDS events according to current antiretrovirals. Methods: Poisson regression was used to compare overall events (fatal or nonfatal AIDS, non-AIDS or death), AIDS events (fatal and nonfatal) or non-AIDS events (fatal or nonfatal) for specific nucleoside pairs and third drugs used with more than 1000 personyears of follow-up (PYFU) after 1 January 2001. Results: Nine thousand, eight hundred and one patients contributed 42372.5 PYFU, during which 1203 (437 AIDS and 766 non-AIDS) events occurred. After adjustment, there was weak evidence of a difference in the overall events rates between nucleoside pairs (global P-value1/40.084), and third drugs (global P-value1/40.031). As compared to zidovudine/lamivudine, patients taking abacavir/lamivudine [adjusted incidence rate ratio (aIRR) 1.22; 95% CI 0.99-1.49] and abacavir and one other nucleoside [aIRR 1.51; 95% CI 1.14-2.02] had an increased incidence of overall events. Comparing the third drugs, those taking unboosted atazanavir had an increased incidence of overall events compared with those taking efavirenz (aIRR 1.46; 95% CI 1.09-1.95). Conclusion: There was little evidence of substantial differences between antiretrovirals in the incidence of clinical disease for a given CD4 cell count or viral load, suggesting there are unlikely to be major unidentified adverse effects of specific antiretrovirals. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.
- Published
- 2013
73. Uptake of tenofovir-based antiretroviral therapy among HIV-HBV-coinfected patients in the EuroSIDA study.
- Author
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Peters L, Mocroft A, Grint D, Moreno S, Calmy A, Jevtovic D, Sambatakou H, Lacombe K, De Wit S, Rockstroh J, Smidt J, Karpov I, Grzeszczuk A, Haziosmanovic V, Gottfredsson M, Radoi R, Kuzovatova E, Orkin C, Ridolfo AL, Zapirain J, and Lundgren J
- Subjects
- Adenine analogs & derivatives, Adenine therapeutic use, Adult, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Coinfection, DNA, Viral antagonists & inhibitors, DNA, Viral biosynthesis, DNA, Viral genetics, Drug Resistance, Viral drug effects, Europe, Female, Guanine analogs & derivatives, Guanine therapeutic use, HIV drug effects, HIV genetics, HIV metabolism, HIV Infections virology, Hepatitis B Surface Antigens blood, Hepatitis B virus drug effects, Hepatitis B virus genetics, Hepatitis B virus metabolism, Hepatitis B, Chronic virology, Humans, Interferon-alpha therapeutic use, Lamivudine therapeutic use, Male, Middle Aged, Organophosphonates therapeutic use, Polyethylene Glycols therapeutic use, Practice Guidelines as Topic, Prospective Studies, Recombinant Proteins therapeutic use, Anti-Retroviral Agents therapeutic use, Drug Utilization statistics & numerical data, HIV Infections drug therapy, Hepatitis B, Chronic drug therapy, Tenofovir therapeutic use
- Abstract
Background: According to guidelines all HIV-HBV-coinfected patients should receive tenofovir-based combination antiretroviral therapy (cART). We aimed to investigate uptake and outcomes of tenofovir-based cART among HIV-HBV patients in the EuroSIDA study., Methods: All hepatitis B surface antigen (HBsAg)+ patients followed up after 1 March 2002 were included. Changes in the proportion taking tenofovir-based cART over time were described. Poisson regression was used to investigate the relationship between tenofovir use and clinical events., Results: 953 HIV-HBV patients were included. Median age was 41 years and patients were predominantly male (85%), White (82%) and ART-experienced (88%). 697 and 256 were from Western and Eastern Europe, respectively. 55 started cART during follow-up, the proportion starting with CD4
+ T-cell count <350 cells/mm3 decreased from 85% to 52% in the periods 2002-2006 to 2007-2015. Tenofovir use, among those taking cART, increased from 4% in 2002 to 73% in 2015. Compared to West, tenofovir use was lower in East in 2005 (7% versus 42%), and remained lower in 2015 (63% versus 76%). Among 602 patients taking tenofovir-based cART during follow-up, 155 (26%) discontinued tenofovir. 27 of all discontinuations were due to adverse effects. Only 14 started entecavir and/or adefovir after tenofovir discontinuation, whereas 10 started pegylated interferon. Tenofovir use was not significantly associated with lower risk of liver-related clinical events (n=51), adjusted incidence rate ratio (IRR) 0.64 (95% CI 0.35, 1.18) for comparing patients on tenofovir with those off tenofovir., Conclusions: Although use of tenofovir-based cART among HIV-HBV patients has increased across Europe, a substantial proportion are still starting cART late and are receiving suboptimal HBV therapy.- Published
- 2018
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74. Older age at the time of liver biopsy is the important risk factor for advanced fibrosis in patients with chronic hepatitis C.
- Author
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Svirtlih N, Jevtovic D, Simonovic J, Delic D, Dokic L, Gvozdenovic E, Boricic I, Nesic Z, Neskovic G, and Urban V
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- Adolescent, Adult, Age Factors, Aged, Biopsy, Needle, Disease Progression, Female, Genotype, Hepacivirus genetics, Humans, Liver pathology, Logistic Models, Male, Middle Aged, Risk Factors, Hepatitis C, Chronic pathology, Liver Cirrhosis pathology
- Abstract
Background/aims: Progression of chronic hepatitis C depends on the host and viral characteristics, duration of infection, co-infection with other viruses, etc. In this study, some of demographic, epidemiological and viral data as risk factors for a degree of liver fibrosis were evaluated., Methodology: A total of 144 patients was investigated (89 males, ages from 16-65 years) classified into two groups, with fibrosis scores 0-3 and 4-6, using the Ishak scoring system. Significant variables were entered into univariate logistic regression model and further multivariate analysis was performed., Results: There were 64% and 36% of patients with fibrosis scores 0-3 and 4-6, respectively. Gender, moderate to heavy alcohol abuse and high viral RNA were equally distributed between both groups. In univariate analysis, the age older than 40, history of intravenous drug abuse, and the genotype 1b were independently associated with different fibrosis scores. Multivariate regression analysis revealed ages older than 40 as the positive (p < 0.001), and younger than 40 as the negative predictive factors for fibrosis scores 4-6 and 0-3 (p < 0.001), respectively., Conclusions: Our results indicate the age over 40 at the time of liver biopsy as the important risk factor for advanced liver disease in chronic hepatitis C according to fibrosis scores.
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- 2007
75. Hepatitis C virus genotypes in Serbia and Montenegro: the prevalence and clinical significance.
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Svirtlih N, Delic D, Simonovic J, Jevtovic D, Dokic L, Gvozdenovic E, Boricic I, Terzic D, Pavic S, Neskovic G, Zerjav S, and Urban V
- Subjects
- Adolescent, Adult, Age Factors, Aged, Alcohol Drinking, Female, Genotype, Hepatitis C pathology, Hepatitis C transmission, Humans, Liver pathology, Male, Middle Aged, Retrospective Studies, Viral Load, Yugoslavia, Hepacivirus genetics, Hepatitis C virology
- Abstract
Aim: To investigate the prevalence of hepatitis C virus (HCV) genotypes in Serbia and Montenegro and their influence on some clinical characteristics in patients with chronic HCV infection., Methods: A total of 164 patients was investigated. Complete history, route of infection, assessment of alcohol consumption, an abdominal ultrasound, standard biochemical tests and liver biopsy were done. Gene sequencing of 5' NTR type-specific PCR or commercial kits was performed for HCV genotyping and subtyping. The SPSS for Windows (version 10.0) was used for univariate regression analysis with further multivariate analysis., Results: The genotypes 1, 2, 3, 4, 1b3a and 1b4 were present in 57.9%, 3.7%, 23.2%, 6.7%, 6.7% and 1.8% of the patients, respectively. The genotype 1 (mainly the subtype 1b) was found to be independent of age in subjects older than 40 years, high viral load, more severe necro-inflammatory activity, advanced stage of fibrosis, and absence of intravenous drug abuse. The genotype 3a was associated with intravenous drug abuse and the age below 40. Multivariate analysis demonstrated age over 40 and intravenous drug abuse as the positive predictive factors for the genotypes 1b and 3a, respectively., Conclusion: In Serbia and Montenegro, the genotypes 1b and 3a predominate in patients with chronic HCV infection. The subtype 1b is characteristic of older patients, while the genotype 3a is common in drug abusers. Association of the subtype 1b with advanced liver disease, higher viral load and histological activity suggests earlier infection with this genotype and eventually its increased pathogenicity.
- Published
- 2007
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