20,207 results on '"Jelinek A"'
Search Results
52. Stressful life events and depression and fatigue in people with multiple sclerosis: a cross-sectional analysis of an international cohort
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Reece, Jeanette C., Neate, Sandra L., Davenport, Rebekah A., Milanzi, Elasma, Nag, Nupur, Bevens, William, Yu, Maggie, Jelinek, George A., and Simpson-Yap, Steve
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- 2024
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53. Exploring mechanisms of change in the metacognitive training for depression
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Miegel, Franziska, Rubel, Julian, Dietrichkeit, Mona, Hagemann-Goebel, Marion, Yassari, Amir H., Balzar, Alicia, Scheunemann, Jakob, and Jelinek, Lena
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- 2024
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54. Science with a small two-band UV-photometry mission I: Mission description and follow-up observations of stellar transients
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Werner, N., Řípa, J., Thöne, C., Münz, F., Kurfürst, P., Jelínek, M., Hroch, F., Benáček, J., Topinka, M., Lukes-Gerakopoulos, G., Zajaček, M., Labaj, M., Prišegen, M., Krtička, J., Merc, J., Pál, A., Pejcha, O., Dániel, V., Jon, J., Šošovička, R., Gromeš, J., Václavík, J., Steiger, L., Segiňák, J., Behar, E., Tarem, S., Salh, J., Reich, O., Ben-Ami, S., Barschke, M. F., Berge, D., Tohuvavohu, A., Sivanandam, S., Bulla, M., Popov, S., and Chang, Hsiang-Kuang
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
This is the first in a collection of three papers introducing the science with an ultra-violet (UV) space telescope on an approximately 130~kg small satellite with a moderately fast re-pointing capability and a real-time alert communication system approved for a Czech national space mission. The mission, called Quick Ultra-Violet Kilonova surveyor - QUVIK, will provide key follow-up capabilities to increase the discovery potential of gravitational wave observatories and future wide-field multi-wavelength surveys. The primary objective of the mission is the measurement of the UV brightness evolution of kilonovae, resulting from mergers of neutron stars, to distinguish between different explosion scenarios. The mission, which is designed to be complementary to the Ultraviolet Transient Astronomy Satellite - ULTRASAT, will also provide unique follow-up capabilities for other transients both in the near- and far-UV bands. Between the observations of transients, the satellite will target other objects described in this collection of papers, which demonstrates that a small and relatively affordable dedicated UV-space telescope can be transformative for many fields of astrophysics., Comment: Accepted for publication in Space Science Reviews
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- 2023
55. Trade-off Between Optimal Efficiency and Envelope Correlation Coefficient for Antenna Clusters
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Neuman, Vojtech, Capek, Miloslav, Jelinek, Lukas, Lehtovuori, Anu, and Viikari, Ville
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Computer Science - Information Theory ,Mathematics - Numerical Analysis - Abstract
This paper introduces a theory for assessing and optimizing the multiple-input-multiple-output performance of multi-port cluster antennas in terms of efficiency, channel correlation, and power distribution. A method based on a convex optimization of feeding coefficients is extended with additional constraints allowing the user to control a ratio between the power radiated by the clusters. The formulation of the problem makes it possible to simultaneously optimize total efficiency and channel correlation with a fixed ratio between power radiated by the clusters, thus examining a trade-off between these parameters. It is shown that channel correlation, total efficiency, and allocation of radiated power are mutually conflicting parameters. The trade-offs are shown and discussed. The theory is demonstrated on a four-element antenna array and on a mobile terminal antenna., Comment: 10 pages, 12 figures
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- 2023
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56. Trust regulation in Social Robotics: From Violation to Repair
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Jelínek, Matouš and Fischer, Kerstin
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Computer Science - Human-Computer Interaction ,Computer Science - Robotics - Abstract
While trust in human-robot interaction is increasingly recognized as necessary for the implementation of social robots, our understanding of regulating trust in human-robot interaction is yet limited. In the current experiment, we evaluated different approaches to trust calibration in human-robot interaction. The within-subject experimental approach utilized five different strategies for trust calibration: proficiency, situation awareness, transparency, trust violation, and trust repair. We implemented these interventions into a within-subject experiment where participants (N=24) teamed up with a social robot and played a collaborative game. The level of trust was measured after each section using the Multi-Dimensional Measure of Trust (MDMT) scale. As expected, the interventions have a significant effect on i) violating and ii) repairing the level of trust throughout the interaction. Consequently, the robot demonstrating situation awareness was perceived as significantly more benevolent than the baseline.
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- 2023
57. Highly-Entangled Polyradical Nanographene with Coexisting Strong Correlation and Topological Frustration
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Song, Shaotang, Solé, Andrés Pinar, Matěj, Adam, Li, Guangwu, Stetsovych, Oleksandr, Soler, Diego, Yang, Huimin, Telychko, Mykola, Li, Jing, Kumar, Manish, Brabec, Jiri, Veis, Libor, Wu, Jishan, Jelinek, Pavel, and Lu, Jiong
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Condensed Matter - Materials Science ,Physics - Chemical Physics - Abstract
Open-shell benzenoid polycyclic aromatic hydrocarbons, known as magnetic nanographenes, exhibit unconventional p-magnetism arising from topological frustration or strong electronic-electron (e-e) interaction. Imprinting multiple strongly entangled spins into polyradical nanographenes creates a major paradigm shift in realizing non-trivial collective quantum behaviors and exotic quantum phases in organic quantum materials. However, conventional design approaches are limited by a single magnetic origin, which can restrict the number of correlated spins or the type of magnetic ordering in open-shell nanographenes. Here, we present a novel design strategy combing topological frustration and e-e interactions to fabricate the largest fully-fused open-shell nanographene reported to date, a 'butterfly'-shaped tetraradical on Au(111). We employed bond-resolved scanning tunneling microscopy and spin excitation spectroscopy to unambiguously resolve the molecular backbone and reveal the strongly correlated open-shell character, respectively. This nanographene contains four unpaired electrons with both ferromagnetic and anti-ferromagnetic interactions, harboring a many-body singlet ground state and strong multi-spin entanglement, which can be well described by many-body calculations. Furthermore, we demonstrate that the nickelocene magnetic probe can sense highly-correlated spin states in nanographene. The ability to imprint and characterize many-body strongly correlated spins in polyradical nanographenes not only presents exciting opportunities for realizing non-trivial quantum magnetism and phases in organic materials but also paves the way toward high-density ultrafast spintronic devices and quantum information technologies., Comment: 17 pages, 4 figures
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- 2023
58. Interventions for increasing medication adherence in heart failure patients: A narrative review
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Libor Jelinek, Jan Vaclavik, and Marie Lazarova
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pharmacotherapy ,heart failure ,barriers to adherence ,interventions to improve adherence ,Medicine - Abstract
Heart failure is one of the critical and most costly medical challenges of the 21st century. It is a chronic debilitating condition and adherence to medication, a precondition for successful treatment is often poor. There are various interventions for improving the adherence. Depending on the goal of the intervention, these are roughly patient centric, healthcare provider centric and system centric. We provide an overview of these interventions with a focus on effectiveness and appropriateness in different clinical situations. Their use can lead to improved patient outcomes and reduced economic burden of the disease.
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- 2024
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59. Comparing single-shot damage thresholds of boron carbide and silicon at the European XFEL
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Marziyeh Tavakkoly, Jaromir Chalupsky, Vera Hajkova, Wolfgang Hillert, Simon Jelinek, Libor Juha, Mikako Makita, Tommaso Mazza, Michael Meyer, Jacobo Montano, Harald Sinn, Vojtech Vozda, and Maurizio Vannoni
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damage threshold ,single-shot damage threshold ,b4c coating ,x-ray mirrors ,xfel ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 ,Crystallography ,QD901-999 - Abstract
Xray free-electron lasers (XFELs) enable experiments that would have been impractical or impossible at conventional X-ray laser facilities. Indeed, more XFEL facilities are being built and planned, with their aim to deliver larger pulse energies and higher peak brilliance. While seeking to increase the pulse power, it is quintessential to consider the maximum pulse fluence that a grazing-incidence FEL mirror can withstand. To address this issue, several studies were conducted on grazing-incidence damage by soft X-ray FEL pulses at the European XFEL facility. Boron carbide (B4C) coatings on polished silicon substrate were investigated using 1 keV photon energy, similar to the X-ray mirrors currently installed at the soft X-ray beamlines (SASE3). The purpose of this study is to compare the damage threshold of B4C and Si to determine the advantages, tolerance and limits of using B4C coatings.
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- 2024
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60. Change in negative mental filter is associated with depression reduction in metacognitive training for depression in older adults (MCT-Silver)
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Brooke C. Schneider, Ruth Veckenstedt, Evangelos Karamatskos, Jakob Scheunemann, Steffen Moritz, Lena Jelinek, and Franziska Miegel
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Metacognition ,Geriatric depression ,Cognitive-behavioral therapy (CBT) ,Thought distortions ,Session-specific effects ,Affective disorders ,Medicine ,Science - Abstract
Abstract Identifying components of modularized psychological interventions that contribute to symptom reduction is essential to improving depression treatment. In a secondary analysis of a randomized controlled trial (RCT), session-specific effects of Metacognitive Training-Silver, a group intervention for older adults with depression, were investigated. Thirty-eight older adults with major depressive disorder or dysthymia participated in up to eight sessions of MCT-Silver. A clinical assessment of depressive symptoms (Hamilton Depression Rating Scale) as well as additional interviews and questionnaires administered as part of the RCT were completed at pre- and post-intervention. Depressive symptoms, negative (meta)cognitive beliefs, emotion regulation strategies and attitudes toward aging were assessed pre- and post-session. The rate of change in each variable per module, elevation following the module in which the variable was addressed, and the rate of change post module were examined via linear mixed models. Clinician-rated depressive symptoms were significantly reduced from pre- to post-intervention (Cohens d = 1.31). Self-reported depression and negative mental filter measured within sessions improved significantly over treatment, whereas black-and-white thinking improved after module #3 (Should Statements, All or Nothing Thinking and Acceptance). Module-specific within-session effects were found for overgeneralization (module #1: Mental Filter) and rumination (module #6: Rumination and Social Withdrawal). Improvement in mental filter in module #1 was significantly associated with depression reduction. This study provides initial evidence that MCT-Silver partially meets its aims of reducing depression and specific cognitive variables within and across sessions. Improvement of the instrument used to measure change may improve detection of module-specific effects. Trial registration: NCT03691402.
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- 2024
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61. Detecting depression severity using weighted random forest and oxidative stress biomarkers
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Mariam Bader, Moustafa Abdelwanis, Maher Maalouf, and Herbert F. Jelinek
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Depression severity ,PHQ-9 ,Biochemistry ,Machine learning ,Oxidative stress ,Medicine ,Science - Abstract
Abstract This study employs machine learning to detect the severity of major depressive disorder (MDD) through binary and multiclass classifications. We compared models that used only biomarkers of oxidative stress with those that incorporate sociodemographic and health-related factors. Data collected from 830 participants, based on the Patient Health Questionnaire (PHQ-9) score, inform our analysis. In binary classification, the Random Forest (RF) classifier achieved the highest Area Under the Curve (AUC) of 0.84 when all features were included. In multiclass classification, the AUC improved from 0.84 with only oxidative stress biomarkers to 0.88 when all characteristics were included. To address data imbalance, weighted classifiers, and Synthetic Minority Over-sampling Technique (SMOTE) approaches were applied. Weighted random forest (WRF) improved multiclass classification, achieving an AUC of 0.91. Statistical tests, including the Friedman test and the Conover post-hoc test, confirmed significant differences between model performances, with WRF using all features outperforming others. Feature importance analysis shows that oxidative stress biomarkers, particularly GSH, are top ranked among all features. Clinicians can leverage the results of this study to improve their decision-making processes by incorporating oxidative stress biomarkers in addition to the standard criteria for depression diagnosis.
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- 2024
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62. Refining the 2022 OJ 287 impact flare arrival epoch
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Valtonen, Mauri J., Zola, Staszek, Gopakumar, Lähteenmäki, Anne, Tornikoski, Merja, Dey, Lankeswar, Gupta, Alok C., Pursimo, Tapio, Knudstrup, Emil, Gomez, Jose L., Hudec, Rene, Jelínek, Martin, Štrobl, Jan, Berdyugin, Andrei V., Ciprini, Stefano, Reichart, Daniel E., Kouprianov, Vladimir V., Matsumoto, Katsura, Drozdz, Marek, Mugrauer, Markus, Sadun, Alberto, Zejmo, Michal, Sillanpää, Aimo, Lehto, Harry J., Nilsson, Kari, Imazawa, Ryo, and Uemura, Makoto
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies ,General Relativity and Quantum Cosmology - Abstract
The bright blazar OJ~287 routinely parades high brightness bremsstrahlung flares, which are explained as being a result of a secondary supermassive black hole (SMBH) impacting the accretion disc of a more massive primary SMBH in a binary system. The accretion disc is not rigid but rather bends in a calculable way due to the tidal influence of the secondary. Below we refer to this phenomenon as a variable disc level. We begin by showing that these flares occur at times predicted by a simple analytical formula, based on general relativity inspired modified Kepler equation, which explains impact flares since 1888. The 2022 impact flare, namely flare number 26, is rather peculiar as it breaks the typical pattern of two impact flares per 12-year cycle. This is the third bremsstrahlung flare of the current cycle that follows the already observed 2015 and 2019 impact flares from OJ~287. It turns out that the arrival epoch of flare number 26 is sensitive to the level of primary SMBH's accretion disc relative to its mean level in our model. We incorporate these tidally induced changes in the level of the accretion disc to infer that the thermal flare should have occurred during July-August 2022, when it was not possible to observe it from the Earth. Thereafter, we explore possible observational evidence for certain pre-flare activity by employing spectral and polarimetric data from our campaigns in 2004/05 and 2021/22. We point out theoretical and observational implications of two observed mini-flares during January-February 2022., Comment: 29 pages, 6 figures, 1 table. arXiv admin note: text overlap with arXiv:2209.08360
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- 2023
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63. Density-Based Topology Optimization in Method of Moments: Q-factor Minimization
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Tucek, Jonas, Capek, Miloslav, Jelinek, Lukas, and Sigmund, Ole
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Mathematics - Optimization and Control ,Computer Science - Computational Engineering, Finance, and Science - Abstract
Classical gradient-based density topology optimization is adapted for method-of-moments numerical modeling to design a conductor-based system attaining the minimal antenna Q-factor evaluated via an energy stored operator. Standard topology optimization features are discussed, e.g., the interpolation scheme and density and projection filtering. The performance of the proposed technique is demonstrated in a few examples in terms of the realized Q-factor values and necessary computational time to obtain a design. The optimized designs are compared to the fundamental bound and well-known empirical structures. The presented framework can provide a completely novel design, as presented in the second example., Comment: 14 pages, 15 figures
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- 2023
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64. The Upper Bound on Antenna Gain and Its Feasibility as a Sum of Characteristic Gains
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Capek, Miloslav and Jelinek, Lukas
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Physics - Applied Physics ,Physics - Classical Physics - Abstract
The upper bound on antenna gain is expressed as a sum of lossy characteristic modes, specifically, as a sum of characteristic far fields squared. The procedure combines the favorable properties of Harrington's classical approach to maximum directivity and current-density-based approaches. The upper bound is valid for any antenna or array designed in a given design region for which optimal performance is determined. The decomposition into modes makes it possible to study the degrees of freedom of an obstacle, classify its radiation into normal or super-directive currents, and determine their compatibility with a given excitation. The bound considers an arbitrary shape of the design region and specific material distribution. The cost in Q-factor and radiation efficiency is studied. The extra constraint of a self-resonance current is imposed for an electrically small antenna. The examples verify the developed theory, demonstrate the procedure's utility, and provide helpful insight to antenna designers. The feasibility of the optimal gain is studied in detail on an example of end-fire arrays using the aforementioned decomposition of optimal current density into lossy characteristic modes., Comment: 13 pages, 19 figures
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- 2023
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65. Origin of Quasi-Periodic Pulsation at the Base of Kink Unstable Jet
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Mishra, Sudheer K., Sangal, Kartika, Kayshap, Pradeep, Jelinek, Petr, Srivastava, A. K., and Rajaguru, S. P.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
We study a blowout jet that occurs at the west limb of the Sun on August 29$^{th}$, 2014 using high-resolution imaging/spectroscopic observations provided by SDO/AIA and IRIS. An inverse $\gamma$-shape flux-rope appears before the jet{--} morphological indication of the onset of kink instability. The twisted field lines of kink-unstable flux-rope reconnect at its bright knot and launch the blowout jet at $\approx$06:30:43 UT with an average speed of 234 km s$^{-1}$. Just after the launch, the northern leg of the flux rope erupts completely. The time-distance diagrams show multiple spikes or bright dots, which is the result of periodic fluctuations, i.e., quasi-periodic fluctuations (QPPs). The wavelet analysis confirms that QPPs have a dominant period of $\approx$ 03 minutes. IRIS spectra (Si~{\sc iv}, C~{\sc ii}, and Mg~{\sc ii}) may also indicate the occurrence of magnetic reconnection through existence of broad $\&$ complex profiles and bi-directional flows in the jet. Further, we have found that line broadening is periodic with a period of $\approx$ 03 minutes, and plasma upflow is always occurs when the line width is high, i.e., multiple reconnection may produce periodic line broadening. The EM curves also show the same period of $\approx$ 03 minutes in different temperature bins. The images and EM show that this jets spire is mainly cool (chromospheric/transition region) rather than hot (coronal) material. Further, line broadening, intensity, and EM curves have a period of $\approx$03 minutes, which strongly supports that multiple magnetic reconnection triggers QPPs in the blowout jet., Comment: The Astrophysical Journal (In press), 25 pages, 12 figures
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- 2023
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66. Association between gut microbiota and CpG island methylator phenotype in colorectal cancer
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Pyoung Hwa Park, Kelsey Keith, Gennaro Calendo, Jaroslav Jelinek, Jozef Madzo, Raad Z. Gharaibeh, Jayashri Ghosh, Carmen Sapienza, Christian Jobin, and Jean-Pierre J. Issa
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Gut microbiota ,Colorectal cancer ,CpG island methylator phenotype ,DNA methylation ,Epigenetics ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
The intestinal microbiota is an important environmental factor implicated in CRC development. Intriguingly, modulation of DNA methylation by gut microbiota has been reported in preclinical models, although the relationship between tumor-infiltrating bacteria and CIMP status is currently unexplored. In this study, we investigated tumor-associated bacteria in 203 CRC tumor cases and validated the findings using The Cancer Genome Atlas datasets. We assessed the abundance of Bacteroides fragilis, Escherichia coli, Fusobacterium nucleatum, and Klebsiella pneumoniae through qPCR analysis and observed enrichment of all four bacterial species in CRC samples. Notably, except for E. coli, all exhibited significant enrichment in cases of CIMP. This enrichment was primarily driven by a subset of cases distinguished by high levels of these bacteria, which we labeled as “Superhigh”. The bacterial Superhigh status showed a significant association with CIMP (odds ratio 3.1, p-value = 0.013) and with MLH1 methylation (odds ratio 4.2, p-value = 0.0025). In TCGA CRC cases (393 tumor and 45 adj. normal), bacterial taxa information was extracted from non-human whole exome sequencing reads, and the bacterial Superhigh status was similarly associated with CIMP (odds ratio 2.9, p
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- 2024
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67. Corrigendum: Comparative genomics of the Natural Killer Complex in carnivores
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Jan Futas, April L. Jelinek, Pamela A. Burger, and Petr Horin
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CLEC ,KLR ,Natural Killer Complex ,carnivore ,Felids ,genomes ,Immunologic diseases. Allergy ,RC581-607 - Published
- 2024
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68. Peak systolic blood pressure during preparticipation exercise testing in 12,083 athletes: age, sex, and workload-indexed values and predictors
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Petra Pesova, Bogna Jiravska Godula, Otakar Jiravsky, Libor Jelinek, Marketa Sovova, Katarina Moravcova, Jaromir Ozana, Ivan Ranic, Radek Neuwirth, Roman Miklik, Matej Pekar, Libor Sknouril, Vladimir Tuka, and Eliska Sovova
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blood pressure ,exercise testing ,athletes ,SBP/WR slope ,SBP/WR ratio ,Physiology ,QP1-981 - Abstract
AimAssessment of blood pressure during exercise is routine in athletes, but normal values remain equivocal. This study examines the response of systolic blood pressure (SBP) to exercise in a large cohort of athletes and establishes normative values by sex and age.MethodsCompetitive athletes free of cardiovascular disease underwent pre-participation exercise testing on a bicycle ergometer. Resting (SBPrest) and peak blood pressure (SBPpeak), heart rate (HRrest and HRpeak), and power output (WR) were recorded. Workload indexed values were calculated.ResultsThe cohort included 12,083 athletes (median age 15 years, 26.9% female). Median peak exercise SBP was similar between sexes, but WR-indexed measures including SBP/WR ratio and SBP/(WR/kg) slope were higher in females (0.9 vs. 0.7, p < 0.001; 10.94 vs. 9.52, p < 0.001). Univariate analyses revealed significant associations between SBPpeak and several predictors, including sex, age, weight, height, SBPrest, DBPrest, HRrest, HRpeak, and WR (all p < .001). Multivariate analysis showed that SBPrest (beta = 0.353, 95% CI [0.541, 0.609], p < 0.001), height (beta = 0.303, 95% CI [0.360, 0.447], p < 0.001), WR (beta = 0.171, 95% CI [0.029, 0.045], p < 0.001), and age (beta = 0.093, 95% CI [0.162, 0.241], p < 0.001) were the strongest predictors of SBPpeak.ConclusionThis study provides reference values for the interpretation of SBP responses to exercise in athletes. Multivariate analyses highlight the complex interplay of factors influencing peak SBP, including SBPrest, height, WR, age, DBPrest, sex, endurance sport category, and weight. In future studies, these findings may inform the development of personalised training strategies and risk stratification models in athletic populations.
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- 2024
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69. Comparative genomics of the Natural Killer Complex in carnivores
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Jan Futas, April L. Jelinek, Pamela A. Burger, and Petr Horin
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CLEC ,KLR ,Natural Killer Complex ,carnivore ,Felids ,genomes ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundThe mammalian Natural Killer Complex (NKC) harbors genes and gene families encoding a variety of C-type lectin-like proteins expressed on various immune cells. The NKC is a complex genomic region well-characterized in mice, humans and domestic animals. The major limitations of automatic annotation of the NKC in non-model animals include short-read based sequencing, methods of assembling highly homologous and repetitive sequences, orthologues missing from reference databases and weak expression. In this situation, manual annotations of complex genomic regions are necessary.MethodsThis study presents a manual annotation of the genomic structure of the NKC region in a high-quality reference genome of the domestic cat and compares it with other felid species and with representatives of other carnivore families. Reference genomes of Carnivora, irrespective of sequencing and assembly methods, were screened by BLAST to retrieve information on their killer cell lectin-like receptor (KLR) gene content. Phylogenetic analysis of in silico translated proteins of expanded subfamilies was carried out.ResultsThe overall genomic structure of the NKC in Carnivora is rather conservative in terms of its C-type lectin receptor gene content. A novel KLRH-like gene subfamily (KLRL) was identified in all Carnivora and a novel KLRJ-like gene was annotated in the Mustelidae. In all six families studied, one subfamily (KLRC) expanded and experienced pseudogenization. The KLRH gene subfamily expanded in all carnivore families except the Canidae. The KLRL gene subfamily expanded in carnivore families except the Felidae and Canidae, and in the Canidae it eroded to fragments.ConclusionsKnowledge of the genomic structure and gene content of the NKC region is a prerequisite for accurate annotations of newly sequenced genomes, especially of endangered wildlife species. Identification of expressed genes, pseudogenes and gene fragments in the context of expanded gene families would allow the assessment of functionally important variability in particular species.
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- 2024
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70. A Finite Element Study of the Universality and Scalability of an Optimized Universal Talus Implant.
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Ahmed Hassan Hafez, Kinda Khalaf, Herbert Franz Jelinek, Tao Liu, Nadr Jomha, Andreas Schiffer, and Marwan El-Rich
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- 2024
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71. Quantifying Brain Connectivity During Restricted Knee Movement
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Katmah, Rateb, Alskafi, Feryal A., Abuhantash, Ferial, Nasrat, Sara, Hulleck, Abdul Aziz, Al-Ani, Fatimah, Khalaf, Kinda, Jelinek, Herbert F., Tavares, João Manuel R. S., Series Editor, Jorge, Renato Natal, Series Editor, Cohen, Laurent, Editorial Board Member, Doblare, Manuel, Editorial Board Member, Frangi, Alejandro, Editorial Board Member, Garcia-Aznar, Jose Manuel, Editorial Board Member, Holzapfel, Gerhard A., Editorial Board Member, Hughes, Thomas J.R., Editorial Board Member, Kamm, Roger, Editorial Board Member, Li, Shuo, Editorial Board Member, Löhner, Rainald, Editorial Board Member, Nithiarasu, Perumal, Editorial Board Member, Oñate, Eugenio, Editorial Board Member, Perales, Francisco J., Editorial Board Member, Prendergast, Patrick J., Editorial Board Member, Tamma, Kumar K., Editorial Board Member, Vilas-Boas, Joao Paulo, Editorial Board Member, Weiss, Jeffrey, Editorial Board Member, Zhang, Yongjie Jessica, Editorial Board Member, Skalli, Wafa, editor, Laporte, Sébastien, editor, and Benoit, Aurélie, editor
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- 2024
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72. Fractals in the Neurosciences: A Translational Geographical Approach
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Andronache, Ion, Peptenatu, Daniel, Ahammer, Helmut, Radulovic, Marko, Djuričić, Goran J., Jelinek, Herbert F., Russo, Carlo, Di Ieva, Antonio, Schousboe, Arne, Series Editor, and Di Ieva, Antonio, editor
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- 2024
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73. ImageJ in Computational Fractal-Based Neuroscience: Pattern Extraction and Translational Research
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Karperien, Audrey L., Jelinek, Herbert F., Schousboe, Arne, Series Editor, and Di Ieva, Antonio, editor
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- 2024
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74. Point of Care Testing (POCT) in Psychopathology Using Fractal Analysis and Hilbert Huang Transform of Electroencephalogram (EEG)
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Khan, Mohammed Sakib Ihsan, Jelinek, Herbert F., Schousboe, Arne, Series Editor, and Di Ieva, Antonio, editor
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- 2024
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75. Morphology and Fractal-Based Classifications of Neurons and Microglia in Two and Three Dimensions
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Karperien, Audrey L., Jelinek, Herbert F., Schousboe, Arne, Series Editor, and Di Ieva, Antonio, editor
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- 2024
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76. Box-Counting Fractal Analysis: A Primer for the Clinician
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Karperien, Audrey L., Jelinek, Herbert F., Schousboe, Arne, Series Editor, and Di Ieva, Antonio, editor
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- 2024
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77. Prompt emission and early optical afterglow of VHE detected GRB 201015A and GRB 201216C: onset of the external forward shock
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Ror, Amit Kumar, Gupta, Rahul, Jelínek, Martin, Pandey, Shashi Bhushan, Castro-Tirado, A. J., Hu, Y. -D., Maleňáková, Alžběta, Štrobl, Jan, Thöne, Christina C., Hudec, René, Karpov, Sergey, Kumar, Amit, Aryan, A., Oates, S. R., Fernández-García, E., del Pulgar, C. Pérez, Caballero-García, M. D., Castellón, A., Carrasco-García, I. M., Pérez-García, I., Terol, A. J. Reina, and Rendon, F.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present a detailed prompt emission and early optical afterglow analysis of the two very high energy (VHE) detected bursts GRB 201015A and GRB 201216C, and their comparison with a subset of similar bursts. Time-resolved spectral analysis of multi-structured GRB 201216C using the Bayesian binning algorithm revealed that during the entire duration of the burst, the low energy spectral index ($\alpha_{\rm pt}$) remained below the limit of the synchrotron line of death. However, statistically some of the bins supported the additional thermal component. Additionally, the evolution of spectral parameters showed that both peak energy (Ep) and $\alpha_{\rm pt}$ tracked the flux. These results were further strengthened using the values of the physical parameters obtained by synchrotron modeling of the data. Our earliest optical observations of both bursts using FRAM-ORM and BOOTES robotic telescopes displayed a smooth bump in their early optical light curves, consistent with the onset of the afterglow due to synchrotron emission from an external forward shock. Using the observed optical peak, we constrained the initial bulk Lorentz factors of GRB 201015A and GRB 201216C to $\Gamma_0$ = 204 and $\Gamma_0$ = 310, respectively. The present early optical observations are the earliest known observations constraining outflow parameters and our analysis indicate that VHE-detected bursts could have a diverse range of observed luminosity within the detectable redshift range of present VHE facilities., Comment: 40 pages, 17 figures, 13 tables, accepted for publication in ApJ
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- 2022
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78. Exploratory risk prediction of type II diabetes with isolation forests and novel biomarkers
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Hibba Yousef, Samuel F. Feng, and Herbert F. Jelinek
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Diabetes ,Inflammation ,Oxidative stress ,Mitochondrial dysfunction ,Isolation forest ,Predictive modelling ,Medicine ,Science - Abstract
Abstract Type II diabetes mellitus (T2DM) is a rising global health burden due to its rapidly increasing prevalence worldwide, and can result in serious complications. Therefore, it is of utmost importance to identify individuals at risk as early as possible to avoid long-term T2DM complications. In this study, we developed an interpretable machine learning model leveraging baseline levels of biomarkers of oxidative stress (OS), inflammation, and mitochondrial dysfunction (MD) for identifying individuals at risk of developing T2DM. In particular, Isolation Forest (iForest) was applied as an anomaly detection algorithm to address class imbalance. iForest was trained on the control group data to detect cases of high risk for T2DM development as outliers. Two iForest models were trained and evaluated through ten-fold cross-validation, the first on traditional biomarkers (BMI, blood glucose levels (BGL) and triglycerides) alone and the second including the additional aforementioned biomarkers. The second model outperformed the first across all evaluation metrics, particularly for F1 score and recall, which were increased from 0.61 ± 0.05 to 0.81 ± 0.05 and 0.57 ± 0.06 to 0.81 ± 0.08, respectively. The feature importance scores identified a novel combination of biomarkers, including interleukin-10 (IL-10), 8-isoprostane, humanin (HN), and oxidized glutathione (GSSG), which were revealed to be more influential than the traditional biomarkers in the outcome prediction. These results reveal a promising method for simultaneously predicting and understanding the risk of T2DM development and suggest possible pharmacological intervention to address inflammation and OS early in disease progression.
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- 2024
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79. Refining the prediction for OJ 287 next impact flare arrival epoch
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Valtonen, Mauri J., Zola, Staszek, Gopakumar, A., McCall, Callum, Jermak, Helen, Dey, Lankeswar, Komossa, S., Pursimo, Tapio, Knudstrup, Emil, Grupe, Dirk, Gomez, Jose L., Hudec, Rene, Jelinek, Martin, Strobl, Jan, Berdyugin, Andrei V., Ciprini, Stefano, Reichart, Daniel E., Kouprianov, Vladimir V., Matsumoto, Katsura, Drozdz, Marek, Mugrauer, Markus, Sadun, Alberto, Zejmo, Michal, Sillanpaa, Aimo, Lehto, Harry J., and Nilsson, Kari
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The bright blazar OJ~287 routinely parades high brightness bremsstrahlung flares which are explained as being a result of a secondary supermassive black hole (SMBH) impacting the accretion disk of a primary SMBH in a binary system. We begin by showing that these flares occur at times predicted by a simple analytical formula, based on the Kepler equation, which explains flares since 1888. The next impact flare, namely the flare number 26, is rather peculiar as it breaks the typical pattern of two impact flares per 12 year cycle. This will be the third bremsstrahlung flare of the current cycle that follows the already observed 2015 and 2019 impact flares from OJ~287. Unfortunately, astrophysical considerations make it difficult to predict the exact arrival epoch of the flare number 26. In the second part of the paper, we describe our recent OJ~287 observations. They show that the pre-flare light curve of flare number 22, observed in 2005, exhibits similar activity as the pre-flare light curve in 2022, preceding the expected flare number 26 in our model. We argue that the pre-flare activity most likely arises in the primary jet whose activity is modulated by the transit of the secondary SMBH through the accretion disk of the primary. Observing the next impact flare of OJ~287 in October 2022 will substantiate the theory of disk impacts in binary black hole systems., Comment: 16 pages, 2 figures
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- 2022
80. Iterative Calculation of Characteristic Modes Using Arbitrary Full-wave Solvers
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Lundgren, Johan, Schab, Kurt, Capek, Miloslav, Gustafsson, Mats, and Jelinek, Lukas
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Physics - Computational Physics ,Mathematics - Numerical Analysis - Abstract
An iterative algorithm is adopted to construct approximate representations of matrices describing the scattering properties of arbitrary objects. The method is based on the implicit evaluation of scattering responses from iteratively generated excitations. The method does not require explicit knowledge of any system matrices (e.g., stiffness or impedance matrices) and is well-suited for use with matrix-free and iterative full-wave solvers, such as FDTD, FEM, and MLFMA. The proposed method allows for significant speed-up compared to the direct construction of a full transition matrix or scattering dyadic. The method is applied to the characteristic mode decomposition of arbitrarily shaped obstacles of arbitrary material distribution. Examples demonstrating the speed-up and complexity of the algorithm are studied with several commercial software packages., Comment: 5 pages, 2 figures, 2 algorithms
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- 2022
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81. Performance Bounds of Magnetic Traps for Neutral Particles
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Liska, Jakub, Jelinek, Lukas, and Capek, Miloslav
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Physics - Computational Physics ,Physics - Plasma Physics - Abstract
Knowledge of the fundamental limitations on a magnetic trap for neutral particles is of paramount interest to designers as it allows for the rapid assessment of the feasibility of specific trap requirements or the quality of a given design. In this paper, performance limitations are defined for convexity of magnetic trapping potential and bias field using a local approximation in the trapping center. As an example, the fundamental bounds are computed for current supporting regions in the form of a spherical shell, a cylindrical region, and a box. A Pareto-optimal set considering both objectives is found and compared with known designs of the Baseball trap and Ioffe-Pritchard trap. The comparison reveals a significant gap in the performance of classical trap designs from the fundamental limitations. This indicates a possibility of improved trap designs and modern techniques of shape synthesis are applied in order to prove their existence. The topologically optimized traps perform almost two times better as compared to conventional designs. Last, but not least, the developed framework might serve as a prototype for the formulation of fundamental limitations on plasma confinement in a wider sense., Comment: 10 pages, 10 figures
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- 2022
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82. The GaN yellow-luminescence-related surface state and its interaction with air
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Turkulets, Yury, Shauloff, Nitzan, Chaulker, Or Haim, Shapira, Yoram, Jelinek, Raz, and Shalish, Ilan
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Condensed Matter - Materials Science - Abstract
Yellow luminescence (YL) is probably the longest and most studied defect-related luminescence band in GaN, yet its electronic structure or chemical identity remain unclear. Most of the theoretical work so far has attributed the feature to bulk defects, whereas spectroscopic studies have suggested a surface origin. Here, we apply deep level spectroscopy using sub-bandgap surface photovoltage that provides the energy distribution of the surface charge density. Comparison of surface charge spectra obtained under identical conditions before and after various surface treatments reveals the dynamics of the surface charge density. Further comparison with spectra of the entire state obtained using photoluminescence shows how the charge density stored in YL-related defects is eliminated upon a mild anneal in vacuum. This suggests that the YL-related defect involves a certain molecule adsorbed on the GaN surface, possibly in a complex with an intrinsic surface defect. The observed interaction with air strongly indicates that the YL-related deep level is a surface state., Comment: Added US DOD Document Control Number (DCN) and distribution statement
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- 2022
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83. Quick Ultra-VIolet Kilonova surveyor (QUVIK)
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Werner, N., Řípa, J., Münz, F., Hroch, F., Jelínek, M., Krtička, J., Zajaček, M., Topinka, M., Dániel, V., Gromeš, J., Václavík, J., Steiger, L., Lédl, V., Seginak, J., Benáček, J., Budaj, J., Faltová, N., Gális, R., Jadlovský, D., Janík, J., Kajan, M., Karas, V., Korčáková, D., Kosiba, M., Krtičková, I., Kubát, J., Kubátová, B., Kurfürst, P., Labaj, M., Mikulášek, Z., Pál, A., Paunzen, E., Piecka, M., Prišegen, M., Ramezani, T., Skarka, M., Szász, G., Thöne, C., and Zejda, M.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present a near-UV space telescope on a ~70kg micro-satellite with a moderately fast repointing capability and a near real-time alert communication system that has been proposed in response to a call for an ambitious Czech national mission. The mission, which has recently been approved for Phase 0, A, and B1 study shall measure the brightness evolution of kilonovae, resulting from mergers of neutron stars in the near-UV band and thus it shall distinguish between different explosion scenarios. Between the observations of transient sources, the satellite shall perform observations of other targets of interest, a large part of which will be chosen in open competition., Comment: SPIE Astronomical Telescopes and Instrumentation
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- 2022
84. Quantifying the performances of SU-8 microfluidic devices: high liquid water tightness, long-term stability, and vacuum compatibility
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Pashayev, Said, Lhermerout, Romain, Roblin, Christophe, Alibert, Eric, Barbat, Jerome, Desgarceaux, Rudy, Jelinek, Remi, Chauveau, Edouard, Tahir, Saïd, Jourdain, Vincent, Jabbarov, Rasim, Henn, Francois, and Noury, Adrien
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- 2024
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85. Catalytic physiological amyloids
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Arad, Elad, primary and Jelinek, Raz, additional
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- 2024
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86. Quantifying Brain Connectivity During Restricted Knee Movement
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Katmah, Rateb, primary, Alskafi, Feryal A., additional, Abuhantash, Ferial, additional, Nasrat, Sara, additional, Hulleck, Abdul Aziz, additional, Al-Ani, Fatimah, additional, Khalaf, Kinda, additional, and Jelinek, Herbert F., additional
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- 2024
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87. Sociodemographic, Health, and Lifestyle-Related Characteristics Associated With the Commencement and Completion of a Web-Based Lifestyle Educational Program for People With Multiple Sclerosis: Randomized Controlled Trial
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Jeanette Reece, Maggie Yu, William Bevens, Steve Simpson-Yap, Rebekah Davenport, George Jelinek, and Sandra Neate
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundDigital health interventions increase access to multiple sclerosis (MS)–related knowledge for people living with MS; however, our understanding of factors associated with engagement in web-based learning is limited. ObjectiveThis study aims to examine associations between participant sociodemographic, health, and lifestyle-related characteristics and the commencement and completion of the Multiple Sclerosis Online Course (MSOC) in a randomized controlled trial (RCT). MethodsAn intervention course was developed based on the Overcoming MS Program—an evidence-based lifestyle modification program for MS, and a standard care course was developed based on international MS website information. An RCT was conducted to compare the effectiveness of the intervention course versus the standard care course in improving health outcomes in people living with MS. Participant data were collected from a baseline survey. Associations between baseline participant characteristics and MSOC commencement and completion, respectively, were assessed using multivariate log-binomial regression. ResultsOverall, 1893 participants enrolled in the RCT, and 45.27% (n=857) completed the baseline survey: 23.5% (n=444) in the intervention course and 21.8% (n=413) in the standard care course. Of these 857 participants, 631 (73.6%) commenced the standard care course or intervention course, and 49.1% (218/444) and 54.2% (224/413) completed the intervention course and standard care course, respectively. University education, partnered relationship status, and higher mental and physical quality of life were associated with 19%, 12%, 20%, and 22% higher rates of course commencement, respectively. Clinically significant fatigue was associated with a 10% reduction in the likelihood of commencement. Strongest associations with intervention course completion included middle and older adulthood, male sex, fatigue, and preexisting adherence to a diet program, with 96%, 27%, 24%, and 19% higher rates of completion observed, respectively, whereas higher self-efficacy was associated with up to 35% lower intervention course completion. Associations with standard care course completion included practicing meditation (20% higher completion), whereas employment was associated with 22% lower completion. ConclusionsSociodemographic and clinical factors, as well as lifestyle-related factors, were important factors in MSOC commencement and completion. These data may help guide the design and enhancement of digital health interventions tailored for people living with MS. Trial RegistrationAustralian New Zealand Clinical Trials Registry ACTRN12621001605886; https://tinyurl.com/2vyve9p9 International Registered Report Identifier (IRRID)RR2-10.1186/s12883-023-03298-0
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- 2024
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88. Characteristic Mode Decomposition Using the Scattering Dyadic in Arbitrary Full-Wave Solvers
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Capek, Miloslav, Lundgren, Johan, Gustafsson, Mats, Schab, Kurt, and Jelinek, Lukas
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Computer Science - Computational Engineering, Finance, and Science ,Physics - Classical Physics - Abstract
Characteristic modes are formulated using the scattering dyadic, which maps incident plane waves to scattered far fields generated by an object of arbitrary material composition. Numerical construction of the scattering dyadic using arbitrary full-wave electromagnetic solvers is demonstrated in examples involving a variety of dielectric and magnetic materials. Wrapper functions for computing characteristic modes in method-of-moments, finite-difference time domain, and finite element solvers are provided as supplementary material., Comment: 11 pages, 10 figures, with supplementary material (github)
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- 2022
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89. Designer magnetic topological graphene nanoribbons
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Song, Shaotang, Ng, Pei Wen, Edalatmanesh, Shayan, Solé, Andrés Pinar, Peng, Xinnan, Kolorenč, Jindřich, Sosnová, Zdenka, Stetsovych, Oleksander, Su, Jie, Li, Jing, Sun, Hongli, Liebig, Alexander, Su, Chenliang, Wu, Jishan, Giessibl, Franz J., Jelinek, Pavel, Chi, Chunyan, and Lu, Jiong
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Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science - Abstract
The interplay of magnetism and topology lies at the heart of condensed matter physics, which offers great opportunities to design intrinsic magnetic topological materials hosting a variety of exotic topological quantum states including the quantum anomalous Hall effect (QAHE), axion insulator state, and Majorana bound states. Extending this concept to one-dimension (1D) systems offers additional rich quantum spin physics with great promise for molecular-scale spintronics. Despite recent progress in the discovery of symmetry-protected topological quantum phases in 1D graphene nanoribbons (GNRs), the rational design and realization of magnetic topological GNRs (MT-GNRs) represents a grand challenge, as one must tackle multiple dimensions of complexity including time-reversal symmetry (TRS), spatial symmetry (width, edge, end geometry) and many-electron correlations. Here, we devised a new route involving the real- and reciprocal-space descriptions by unifying the chemists and physicists perspectives, for the design of such MT-GNRs with non-trivial electronic topology and robust magnetic terminal. Classic Clar's rule offers a conceptually qualitative real-space picture to predict the transition from closed-shell to open-shell with terminal magnetism, and band gap reopening with possible non-trivial electronic topology in a series of wave-like GNRs, which are further verified by first principle calculations of band-structure topology in a momentum-space. With the advance of on-surface synthesis and careful design of molecular precursors, we have fabricated these MT-GNRs with observation of topological edge bands, whose terminal pi-magnetism can be directly captured using a single-nickelocene spin sensor. Moreover, the transition from strong anti-ferromagnetic to weak coupling (paramagnetism-like) between terminal spins can be controlled by tuning the length of MT-GNRs., Comment: 29 pages, 11 figures
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- 2022
90. Z3 Charge Density Wave of Silicon Atomic Chains on a Vicinal Silicon Surface
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Do, Euihwan, Park, Jae Whan, Stetsovych, Oleksandr, Jelinek, Pavel, and Yeom, Han Woong
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
An ideal one-dimensional electronic system is formed along atomic chains on Au-decorated vicinal silicon surfaces but the nature of its low temperature phases has been puzzled for last two decades. Here, we unambiguously identify the low temperature structural distortion of this surface using high resolution atomic force microscopy and scanning tunneling microscopy. The most important structural ingredient of this surface, the step-edge Si chains are found to be strongly buckled, every third atoms down, forming trimer unitcells. This observation is consistent with the recent model of rehybridized dangling bonds and rules out the antiferromagnetic spin ordering proposed earlier. The spectroscopy and electronic structure calculation indicate a charge density wave insulator with a Z3 topology making it possible to exploit topological phases and excitations. Tunneling current was found to substantially lower the energy barrier between three degenerate CDW states, which induces a dynamically fluctuating CDW at very low temperature.
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- 2022
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91. Children's Astronomy. Development of the Shape of the Earth Concept in Polish Children between 5 and 10 Years of Age
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Jelinek, Jan Amos
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The Earth's shape concept develops as consecutive cognitive problems (e.g., the location of people and trees on the spherical Earth) are gradually resolved. Establishing the order of problem solving may be important for the organisation of teaching situations. This study attempted to determine the sequence of problems to be resolved based on tasks included in the EARTH2 test. The study covered a group of 444 children between 5 and 10 years of age. It captured the order in which children solve cognitive problems on the way to constructing a science-like concept. The test results were compared with previous studies. The importance of cultural influences connected to significant differences (24%) in test results was emphasised. Attention was drawn to the problem of the consistency of the mental model approach highlighted in the literature. The analysis of the individual sets of answers provided a high level of consistency of indications referring to the same model (36%), emphasising the importance of the concept of mental models.
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- 2021
92. PBDEs and dechlorane plus contamination in community e-waste recycling: Environmental and health implications in Northeastern Thailand
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Walaska, Hana, Dvorska, Alice, Petrlik, Jindrich, Boontongmai, Thitikorn, Bubphachat, Nichchawan, Strakova, Jitka, Thowsakul, Chutimon, Teebthaisong, Akarapon, Jelinek, Nikola, Grechko, Valeriya, Saetang, Penchom, Jeungsmarn, Punyathorn, Phanphet, Prakaikan, Pulawun, Surachate, Sykorova, Aneta, Gramblicka, Tomas, Pulkrabova, Jana, and Carpenter, David O.
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- 2024
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93. Spatial transcriptomics reveals profound subclonal heterogeneity and T-cell dysfunction in extramedullary myeloma
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John, Mara, Helal, Moutaz, Duell, Johannes, Mattavelli, Greta, Stanojkovska, Emilia, Afrin, Nazia, Leipold, Alexander M., Steinhardt, Maximilian J., Zhou, Xiang, Žihala, David, Anilkumar Sithara, Anjana, Mersi, Julia, Waldschmidt, Johannes M., Riedhammer, Christine, Kadel, Sofie-Katrin, Truger, Marietta, Werner, Rudolf A., Haferlach, Claudia, Einsele, Hermann, Kretzschmar, Kai, Jelínek, Tomáš, Rosenwald, Andreas, Kortüm, K. Martin, Riedel, Angela, and Rasche, Leo
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- 2024
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94. Return of genetic research results in 21,532 individuals with autism
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Aarrestad, Alexandria, Abbeduto, Leonard, Aberbach, Gabriella, Aberle, Shelley, Adegbite, Adediwura, Adeniji, Debbie, Aguilar, Maria, Ahlers, Kaitlyn, Albright, Charles, Alessandri, Michael, Algaze, Zach, Alkazi, Jasem, Amador, Raquel, Amaral, David, Amon, Logan, Amundsen, Leonor, Andrus, Alicia, Anglo, Claudine, Annett, Robert, Arar, Adam, Arnold, Jonathan, Arriaga, Ivette, Arzate, Eduardo, Ashley, Raven, Aslamy, Leilemah, Baalman, Kelli, Baer, Melissa, Bahi, Ethan, Bailey, Joshua, Baldlock, Zachary, Banks, Grabrielle, Baraghoshi, Gabriele, Bardett, Nicole, Barrett, Mallory, Bartholomew, Yan, Bates, Heidi, Beard, Katie, Becerra, Juana, Beckwith, Malia, Beechan, Paige, Beeson, Landon, Beeson, Josh, Bell, Brandi, Belli, Monica, Bentley, Dawn, Berger, Natalie, Berman, Anna, Bernier, Raphael, Berry-Kravis, Elizabeth, Berwanger, Mary, Birdwell, Shelby, Blank, Elizabeth, Bond, Rebecca, Booker, Stephanie, Bordofsky, Aniela, Bower, Erin, Bowers, Lukas, Bradley, Catherine, Brayer, Heather, Brewster, Stephanie, Brown, Hallie, Brown, Alison, Brown, Melissa, Buck, Catherine, Buescher, Cate, Bullon, Kayleigh, Buraima, Joy, Butter, Eric, Caamano, Amalia, Cacciato, Nicole, CaI, Wenteng, Calderon, Norma, Callahan, Kristen, Camba, Alexies, Campo-Soria, Claudia, Caprara, Giuliana, Carbone, Paul, Carpenter, Laura, Carpenter, Sarah, Casseus, Myriam, Casten, Lucas, Catherine, Sullivan, Chappo, Ashley, Chavez, Kimberly, Cheathem-Johnson, Randi, Chen, Tia, Chintalapalli, Sharmista, Cho, Daniel, Choi, Y.B., Clark, Nia, Clark, Renee, Coffman, Marika, Coleman, Laura, Coleman, Kendra, Collins, Alister, Columbi, Costanza, Comitre, Joaquin, Constant, Stephanie, Contra, Arin, Conyers, Sarah, Cooper, Lindsey, Cooper, Cameron, Coppola, Leigh, Corlett, Allison, Corrales, Lady, Correa, Dahriana, Cottrell, Hannah, Coughlin, Michelle, Courchesne, Eric, Coury, Dan, Crocetti, Deana, Croson, Carrie, Crowell, Judith, Cubells, Joseph, Cunningham, Sean, Currin, Mary, Cutri, Michele, D'Ambrosi, Sophia, David, Giancarla, Davis, Ayana, Davis, Sabrina, Decius, Nickelle, Delaporte, Jennifer, DeMarco, Lindsey, Dennis, Brandy, Deronda, Alyssa, Dhawan, Esha, Dichter, Gabriel, Doan, Ryan, Dominick, Kelli, Ortega, Leonardo Dominquez, Doyle, Erin, Drayton, Andrea, DuBois, Megan, Dudley, Johnny, Duhon, Gabrielle, Duncan, Grabrielle, Duncan, Amie, Dunlevy, Megan, Dyer, Meaghan, Earl, Rachel, Edmonson, Catherine, Eldred, Sara, Elliott, Nelita, Emery, Brooke, Enright, Barbara, Erb, Sarah, Erickson, Craig, Esler, Amy, Estevez, Liza, Fanta, Anne, Fassler, Carrie, Fatemi, Ali, Fazal, Faris, Featherston, Marilyn, Ferguson, Jonathan, Fish, Angela, Fitzgerald, Kate, Flores, Kathleen, Fombonne, Eric, Foster, Margaret, Fowler, Tiffany, Fox, Emma, Fox, Emily, Francis, Sunday, Frayne, Margot, Froman, Sierra, Fuller, Laura, Galbraith, Virginia, Gallimore, Dakota, Gambrell, Ariana, Gazestani, Vahid, Geisheker, Madeleine R., Gerdts, Jennifer, Geschwind, Daniel, Ghaziuddin, Mohammad, Ghina, Haidar, Given, Erin, Goetz, Mykayla, Gong, Jared, Gonring, Kelsey, Gonzalez, Natalia, Gonzalez, Antonio, Goodwill, Ellie, Gordon, Rachel, Graham, Carter, Gray, Catherine, Grimes, Ellen, Griswold, Anthony, Gu, Pan, Guilfoyle, Janna, Gulsrud, Amanda, Gunderson, Jaclyn, Gunter, Chris, Gupta, Sanya, Gupta, Abha, Gutierrez, Anibal, Gwynette, Frampton, Haidar, Ghina, Hale, Melissa, Haley, Monica, Hall, Lauren K., Hamer, Kira, Hamilton, Piper, Hanna, Nathan, Hardan, Antonio, Harkins, Christina, Harrell, Eldric, Harris, Jill, Harris, Nina, Hayes, Caitlin, Hayse, Braden, Heckers, Teryn, Heerwagen, Kathryn, Hennelly, Daniela, Herbert, Lynette, Hermle, Luke, Hernandez, Briana, Herrera, Clara, Hess, Amy, Heyman, Michelle, Higgins, Lorrin, Phillips, Brittani Hilscher, Hirst, Kathy, Ho, Theodore, Hoffman, Emily, Hojlo, Margaret, Honaker, Makayla, Hong, Michael, Hooks, Gregory, Horner, Susannah, Horton, Danielle, Hounchell, Melanie, Howes, Dain, Huang-Storm, Lark, Hunter, Samantha, Hutter, Hanna, Hyde, Emily, Ibanez, Teresa, Ingram, Kelly, Istephanous, Dalia, Jacob, Suma, Jarratt, Andrea, Jelinek, Anna, Johnson, Mary, Jones, Mya, Jones, Garland, Jones, Mark, Jorgenson, Alissa, Judge, Jessyca, Kalb, Luther, Kalmus, Taylor, Kang, Sungeun, Kangas, Elizabeth, Kanne, Stephen, Kaplan, Hannah, Khan, Sara, Kim, Sophy, Kim, Annes, Kitaygordsky, Alex, Klaiman, Cheryl, Klever, Adam, Koene, Hope, Koomar, Tanner, Koza, Melinda, Kramer, Sydney, Krushena, Meghan, Kurtz-Nelson, Eva, Lamarche, Elena, Lampert, Erica, Lamy, Martine, Landa, Rebecca, Lebron-Cruz, Alexa, Lechniak, Holly, Lee, Soo, Leight, Bruce, Lerner, Matthew, Lesher, Laurie, Lewis, Courtney, Li, Hai, Li, Deana, Libove, Robin, Lillie, Natasha, Limon, Danica, Limpoco, Desi, Lin, Melody, Littlefield, Sandy, Lobisi, Brandon, Locarno, Laura, Long, Nancy, Long, Bailey, Long, Kennadie, Lopez, Marilyn, Lovering, Taylor, Lozano, Ivana, Lucio, Daniella, Luo, Addie, Luu, My-Linh, Lyon, Audrey, Ma, Julia, Madi, Natalie, Malloch, Lacy, Mankaryous, Reanna, Manning, Patricia, Mantey, Alvin, Marini, Richard, Marsden, Alexandra, Marwali, Clarissa, Marzano, Gabriela, Mason, Andrew, Mastel, Sarah, Mathai, Sheena, Matthews, Emily, Matusoff, Emma, Maxim, Clara, McCarthy, Caitlin, McClellen, Lynn, Mccoy, Nicole, McCullough, Kaylen, McDonald, Brooke, McGalliard, Julie, McIntyre, Anne-Marie, McKenna, Brooke, McKenzie, Alexander, McTaggart, Megan, Meinen, Hannah, Melnyk, Sophia, Miceli, Alexandra, Michaels, Sarah, Michaelson, Jacob, Milan, Estefania, Miller, Melissa, Milliken, Anna, Minton, Kyla, Mitchell, Terry, Gunn, Amanda Moffitt, Mohiuddin, Sarah, Money, Gina, Montezuma, Jessie, Mooney, Lindsey, Moore, Margo, Morales-Lara, Amy, Morgan, Kelly, Morotti, Hadley, Morrier, Michael, Munoz, Maria, Lavanderos, Ambar Munoz, Murali, Shwetha, Murillo, Karla, Murray, Kailey, Myhre, Erin, Neely, Jason, Neuhaus, Emily, Newman, Olivia, Nguyen, Richard, Nguyen, Victoria, Nichols, Evelyn, Nicholson, Amy, Niederhauser, Melanie, Norris, Megan, Norton, Shai, Nowell, Kerri, O’Brien, Kaela, O’Meara, Mitchell, O’Neil, Molly, O'Roak, Brian, Ocampo, Edith, Ochoa-Lubinoff, Cesar, Oft, Anna, Orobio, Jessica, Ortiz, Crissy, Ousley, Opal, Oyeyemi, Motunrayo, Pacheco, Lillian, Palacios, Valeria, Palmer, Samiza, Palmeri, Isabella, Pama, Katrina, Pandey, Juhi, Paolicelli, Anna Marie, Parker, Jaylaan, Patterson, Morgan, Pawlowski, Katherine, Pedapati, Ernest, Pepper, Michah, Perrin, Jeremy, Peura, Christine, Phillips, Diamond, Pierce, Karen, Piven, Joseph, Plate, Juhi, Polanco, Jose, Pott-Schmidt, Natalie, Pramparo, Tiziano, Pratt, Taleen, Prock, Lisa, White, Stormi Pulver, Qi, Hongjian, Qiu, Shanping, Queen, Eva, Questel, Marcia, Quinones, Ashley, Rambeck, Desiree, Randall, Shelley, Ranganathan, Vaikunt, Raymond, Laurie, Rayos, Madelyn, Real, Kelly, Rhea, Anna, Rice, Catherine, Richardson, Harper, Riffle, Stacy, Robertson, Tracy, Roby, Erin, Rocha, Ana, Roche, Casey, Rodriguez, Nicki, Rodriguez, Bianca, Roeder, Katherine, Rojas, Daniela, Rosewater, Jacob, Rosselott, Hilary, Runyan, Payton, Russo, Nicole, Rutter, Tara, Ruzzo, Elizabeth, Sahin, Mustafa, Salem, Fatima, Sanchez, Rebecca, Sanders, Muave, Sanderson, Tayler, Sandhu, Sophie, Sanford, Katelyn, Santangelo, Susan, Santulli, Madeline, Sarver, Dustin, Savage, Madeline, Scherr, Jessica, Schneider, Hoa, Schools, Hayley, Schoonover, Gregory, Schultz, Robert, Sebolt, Cheyanne, Shaffer, Rebecca, Shameen, Sana, Sherard, Curry, Shikov, Roman, Shillington, Amelle, Shir, Mojeeb, Shocklee, Amanda, Shrier, Clara, Shulman, Lisa, Siegel, Matt, Simon, Andrea, Simon, Laura, Singh, Arushi, Singh, Vini, Smalley, Devin, Smith, Kaitlin, Smith, Chris, Smith, Ashlyn, Soorya, Latha, Soscia, Julia, Soucy, Aubrie, Stchur, Laura, Steele, Morgan, Srishyla, Diksha, Stamps, Danielle, Sussman, Nicole, Swanson, Amy, Sweeney, Megan, Sziklay, Anthony, Tafolla, Maira, Taiba, Jabeen, Takahashi, Nicole, Terroso, Sydney, Strathearn, Camilla, Thomas, Taylor, Thompson, Samantha, Touchette, Ellyn, Townsend, Laina, Trog, Madison, Tsai, Katherine, Tseng, Angela, Tshering, Paullani, Tso, Ivy, Valicenti-Mcdermott, Maria, VanMetre, Bonnie, VanWade, Candace, Turecki, Samuel, Vargo, Kerrigan, Vattuone, Cristiana, Veenstra-Vanderweele, Jeremy, Vehorn, Alison, Benitez Velazquez, Alan Jesus, Verdi, Mary, Villalobos, Michele, Vrittamani, Lakshmi, Wainer, Allison, Wallace, Jermel, Walston, Corrie, Wang, Jiayaho, Ward, Audrey, Warren, Zachary, Washington, Katherine, Westerkamp, Grace, White, Sabrina, Wink, Logan, Winoto, Fiona, Winters, Sarah, Wodka, Ericka, Xavier, Samantha, Xu, Sidi, Yang, Yi, Yang, WhaJames, Yang, Amy, Yinger, Meredith, Yu, Timothy, Zaro, Christopher, Zha, Cindy, Zhang, Haicang, Zhao, Haoquan, Zick, Allyson, Salmon, Lauren Ziegelmayer, Wright, Jessica R., Astrovskaya, Irina, Barns, Sarah D., Goler, Alexandra, Zhou, Xueya, Shu, Chang, Snyder, LeeAnne Green, Han, Bing, Shen, Yufeng, Volfovsky, Natalia, Hall, Jacob B., Feliciano, Pamela, and Chung, Wendy K.
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- 2024
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95. Exploring the Peaks and Potholes: Understanding positive and negative effects of concentrated exposure treatment for obsessive-compulsive disorder
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Jelinek, Lena, Serve, Anna, Pampuch, Saskia, Scheunemann, Jakob, Schultz, Josephine, Miegel, Franziska, Hansen, Bjarne, Hagen, Kristen, Bohnsack, Frances, Gallinat, Jürgen, and Yassari, Amir H.
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- 2024
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96. Physics and chemistry of nitrogen dioxide (NO2) adsorption on gallium nitride (GaN) surface and its interaction with the yellow-luminescence-associated surface state
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Turkulets, Yury, Shauloff, Nitzan, Chaulker, Or Haim, Jelinek, Raz, and Shalish, Ilan
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- 2025
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97. Exploring the cognitive effects of hearing loss in adult rats: Implications for visuospatial attention, social behavior, and prefrontal neural activity
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Stenzel, Mariele, Alam, Mesbah, Witte, Marla, Jelinek, Jonas, Armbrecht, Nina, Armstrong, Adrian, Kral, Andrej, Krauss, Joachim K., Land, Rüdiger, Schwabe, Kerstin, and Johne, Marie
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- 2025
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98. Immunoablative therapy followed by autologous hematopoietic stem cell transplantation as the first-line disease-modifying therapy in patients with multiple sclerosis
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Martin Lachnit, Kamila Zondra Revendova, Pavel Hradilek, Radovan Bunganic, Zdenek Koristek, Tomas Jelinek, Monika Skutova, Radim Piza, Ondrej Volny, Roman Hajek, and Michal Bar
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multiple sclerosis ,immunoablative therapy ,autologous hematopoietic stem cell transplantation ,Medicine - Abstract
Introduction. Immunoablative therapy followed by autologous hematopoietic stem cell transplantation (AHSCT) is one of the possible disease-modifying therapies (DMTs) for patients with multiple sclerosis (MS). In this case series, we would like to present six patients with MS, who underwent AHSCT as the first-line DMT. Case reports. Six MS patients with a rapid progression of disability with or without relapses underwent AHSCT as the first-line DMT at the University Hospital Ostrava between 2018 and 2021. The conditioning regimens for AHSCT used were a medium-intensity regime BEAM (Carmustine, Etoposid, Cytarabin, Melphalan) and low-intensity regime based on Cyclophosphamide. Four out of six patients showed some disability progression after AHSCT, so the rapid progression of MS was just slowed down by AHSCT. One patient developed activity on magnetic resonance imaging three months after AHSCT, and two experienced mild relapses during the follow-up period. None of our patients developed grade 4 non-hematological toxicity; all infections were mild. In one patient, an allergic reaction probably to dimethyl sulfoxide was observed. Conclusion. Our case series of 6 patients shows that AHSCT is a promising therapeutic approach to slow down the rapid progression of clinical disability in MS patients with a good safety profile.
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- 2024
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99. MC180295 is a highly potent and selective CDK9 inhibitor with preclinical in vitro and in vivo efficacy in cancer
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Hanghang Zhang, Chen Huang, John Gordon, Sijia Yu, George Morton, Wayne Childers, Magid Abou-Gharbia, Yi Zhang, Jaroslav Jelinek, and Jean-Pierre J. Issa
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Epigenetic therapy ,CDK9 ,Immunosensitization ,MC180380 ,Anti-tumoral effects ,Medicine ,Genetics ,QH426-470 - Abstract
Abstract Background Inhibition of cyclin-dependent kinase 9 (CDK9), a novel epigenetic target in cancer, can reactivate epigenetically silenced genes in cancer by dephosphorylating the SWI/SNF chromatin remodeler BRG1. Here, we characterized the anti-tumor efficacy of MC180295, a newly developed CDK9 inhibitor. Methods In this study, we explored the pharmacokinetics of MC180295 in mice and rats, and tested the anti-tumor efficacy of MC180295, and its enantiomers, in multiple cancer cell lines and mouse models. We also combined CDK9 inhibition with a DNA methyltransferase (DNMT) inhibitor, decitabine, in multiple mouse models, and tested MC180295 dependence on T cells. Drug toxicity was measured by checking body weights and complete blood counts. Results MC180295 had high specificity for CDK9 and high potency against multiple neoplastic cell lines (median IC50 of 171 nM in 46 cell lines representing 6 different malignancies), with the highest potency seen in AML cell lines derived from patients with MLL translocations. MC180295 is a racemic mixture of two enantiomers, MC180379 and MC180380, with MC180380 showing higher potency in a live-cell epigenetic assay. Both MC180295 and MC180380 showed efficacy in in vivo AML and colon cancer xenograft models, and significant synergy with decitabine in both cancer models. Lastly, we found that CDK9 inhibition-mediated anti-tumoral effects were partially dependent on CD8 + T cells in vivo, indicating a significant immune component to the response. Conclusions MC180380, an inhibitor of cyclin-dependent kinase 9 (CDK9), is an efficacious anti-cancer agent worth advancing further toward clinical use.
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- 2024
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100. MOBA: Rethinking needs and financing for affordable rental and cooperative housing in Central and South-Eastern Europe
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Zsuzsanna Pósfai, Csaba Jelinek, Mara Ferreri, and Camila Cociña
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Political science ,Social history and conditions. Social problems. Social reform ,HN1-995 - Abstract
This conversation starts with the introduction of a large-scale research project conducted in 2022 in eight Central and South-Eastern European countries on how catalytic capital investment can enable the provision of affordable rental and cooperative housing in the region. The results of the project prove that while there is a large potential target group of such alternative housing models in these countries, the currently available housing finance tools are inadequate to help the emergence of the sector. In the second part of the conversation we introduce how MOBA Housing SCE intends to solve this problem through creating a bottom-up quasi revolving fund, which can financially help local projects in their early phase. Finally, we explain how MOBA approaches internationalism, co-housing principles, the need for shifting housing paradigms, and state socialist heritages of cooperativism.
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- 2024
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