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52. Lifestyle changes can be achieved through counseling and follow-up in first-degree relatives of patients with type 2 diabetes. (Research)

Author

Brekke, Hilde K., Jansson, Per-Anders, Mansson, Jan-Eric, and Lenner, Ragnhild A.

Subjects
Exercise -- Health aspects, Life style -- Health aspects, Diet therapy -- Health aspects, Diabetics -- Food and nutrition -- Care and treatment, Type 2 diabetes -- Prevention -- Care and treatment, Food/cooking/nutrition, Prevention, Care and treatment, Food and nutrition, Health aspects
Abstract

Objective To describe two lifestyle prevention strategies tested in first-degree relatives of patients with type 2 diabetes and to present the short-term effects of these strategies on nutrient intake, physical activity pattern, and body weight. Design In this 16-week controlled intervention trial, subjects were assigned to one of three treatment conditions: diet group (D) (n=25), diet and exercise group (DE) (n=30), or control group (C) (n=22). Subjects/setting Non-diabetic relatives of individuals with diabetes were recruited (n=77; men and women; age 25 to 55 years). Intervention Intervention groups received group counseling on two occasions and follow-up through unannounced telephone interviews every 10 days. Counseling regarding diet and physical activity was based on the Nordic Nutrition Recommendations. In addition, increased intake of fatty fish and low glycemic index foods were recommended. Main outcome measures Changes in diet (assessed by food frequency questionnaires), leisure time physical activity (assessed through interviews), fatty acid composition of erythrocyte membrane, and body weight. Statistical analysis One-way analysis of variance and Mann-Whitney U test were used to compare changes among groups. Results Compared with the control group, both intervention groups decreased intake of saturated fatty acids (percent of energy), increased intake of dietary fiber, and reduced average glycemic index of the diet. The ratio of n-6:n-3 fatty acids of the erythrocyte membranes decreased, confirming increased intake of fatty fish. Body weight decreased 1.7 kg (2.1%, P=.030) in group DE, and physical activity increased in the least-active subjects (+70 ruin/week, P Applications/Conclusions Healthy individuals with heredity for type 2 diabetes can achieve desired changes in lifestyle factors associated with increased risk for the disease. J Am Diet Assoc. 2003;103:835-843., Type 2 diabetes is increasing worldwide. There is a strong need for prevention strategies to slow this development, targeting both the population level and individuals at increased risk. Many of [...]

Published
2003

53. Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes

Author

Nitert, Marloes Dekker, Dayeh, Tasnim, Volkov, Peter, Elgzyri, Targ, Hall, Elin, Nilsson, Emma, Yang, Beatrice T., Lang, Stefan, Parikh, Hemang, Wessman, Ylva, Weishaupt, Holger, Attema, Joanne, Abels, Mia, Wierup, Nils, Almgren, Peter, Jansson, Per-Anders, Rönn, Tina, Hansson, Ola, Eriksson, Karl-Fredrik, Groop, Leif, and Ling, Charlotte

Published
2012
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62. Single-Nucleotide Polymorphism rs7754840 of CDKAL1 Is Associated with Impaired Insulin Secretion in Nondiabetic Offspring of Type 2 Diabetic Subjects and in a Large Sample of Men with Normal Glucose Tolerance

Author

Stančáková, Alena, Pihlajamäki, Jussi, Kuusisto, Johanna, Stefan, Norbert, Fritsche, Andreas, Häring, Hans, Andreozzi, Francesco, Succurro, Elena, Sesti, Giorgio, Boesgaard, Trine Welløv, Hansen, Torben, Pedersen, Oluf, Jansson, Per Anders, Hammarstedt, Ann, Smith, Ulf, and Laakso, Markku

Published
2008

65. C-Reactive Protein Concentrations and Level of Physical Activity in Men and Women With Normal and Impaired Glucose Tolerance: A Cross-Sectional Population-Based Study in Sweden.

Author

Hellgren, Margareta I., Larsson, Charlotte A., Daka, Bledar, Petzold, Max, Jansson, Per-Anders, and Lindblad, Ulf

Subjects
PHYSICAL activity measurement, C-reactive protein, GLUCOSE intolerance, GLUCOSE tolerance tests, SEX differences (Biology)
Abstract

Background: We aimed to explore the association between self-reported leisure time physical activity (LTPA) and C-reactive protein (CRP) concentrations in men and women with and without impaired glucose tolerance (IGT). Methods: In a cross-sectional study, a random sample (n = 2,816) was examined with an oral glucose tolerance test, CRP and information about LTPA. Those with IGT or normal glucose tolerance (NGT) and CRP value ≤10 mg/L were selected (n = 2,367) for the study. Results: An inverse association between LTPA and CRP concentrations was observed in the population (P < .001), though, only in men with IGT (P = .023) and in women with NGT. Men with IGT, reporting slight physical activity up to 4 hours a week presented significantly higher CRP concentrations than normoglycemic men (Δ0.6 mg/L, P = .004). However, this difference could not be found in men with IGT reporting more intense physical activity (Δ0.01 mg/L, P = .944). Conclusions: Physical inactivity seems to have greater inflammatory consequences for men (vs. women) with IGT. More importantly, although 4 hours of physical activity per week is more than the usual minimum recommendation, an even greater intensity of LTPA appears to be required to limit subclinical inflammation in men with IGT. [ABSTRACT FROM AUTHOR]

Published
2016
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68. Microdialysis measurements in skin: evidence for significant lactate release in healthy humans

Author

Jansson, Per-Anders, Krogstad, Anne Lene, and Lonnroth, Peter

Subjects
Lactic acid -- Physiological aspects, Skin -- Physiological aspects, Biological sciences
Abstract

Lactate is the major precursor for liver gluconeogenesis. It is produced mainly in skeletal muscles but there is evidence suggesting that lactate is also produced in skin. To determine whether the skin is a another major site of lactate formation, lactate production was measured from the skin of seven lean, healthy men in both the fasting state and during an oral glucose tolerance test (OGTT). Results showed a significant increase in dermal lactate formation after overnight fasting, whereas no significant increase was observed during an OGTT.

Published
1996

70. Plasma metabolomic patterns in patients with exhaustion disorder

Author

Hadrévi, Jenny, Jonsdottir, Ingibjorg H., Jansson, Per-Anders, Eriksson, Jan W., Sjörs, Anna, Hadrévi, Jenny, Jonsdottir, Ingibjorg H., Jansson, Per-Anders, Eriksson, Jan W., and Sjörs, Anna

Abstract

Exhaustion disorder (ED) is a stress-related disorder that often implies a great burden on the individual patient as well as on society. Previous studies have shown that ED is associated with metabolic deviations, such as lowered fasting glucose. Several mechanisms have been discussed as a plausible explanation of the lack of energy described by these patients. Metabolic processes and reduced ability to mobilize energy have been suggested as important factors. This study investigated metabolomics in 20 patients diagnosed with ED and compared them with 21 healthy controls. Plasma metabolic profiles were examined in both fasting and nonfasting (postprandial) conditions. Blood plasma samples were analyzed for metabolite content using gas chromatography mass spectrometry. A total of 62 different metabolites were simultaneously detected in each of the samples. Multivariate models indicated systematic differences between patients with ED and healthy controls in both their fasting and nonfasting plasma metabolite levels. Lysine and octadecenoic acid were more abundant and glutamine, glycine, serine and gluconic acid were less abundant in the patients across both conditions. In the present study, we comprehensively and simultaneously screen for changes in a large number of metabolites. Our results show a difference in systemic metabolites between patients with exhaustion disorder and healthy controls both in the fasting and in the postprandial states. Here, we present new potential biomarkers mirroring exhaustion disorder metabolism.Lay summary Exhaustion disorder (ED) patients suffer from stress-related symptoms including a reduced energy level. This study investigates the body's metabolism in patients with ED, both fasting and after a meal. New potential markers that may help future investigations on ED were identified.

Published
2019
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80. Glucose tolerance and mobilization of neutrophils in smokers with and without chronic obstructive pulmonary disease

Author

Pournaras, Nikolaos, primary, Andersson, Anders, additional, Kovach, Melissa, additional, Ganguly, Koustav, additional, Padra, Medea, additional, Asgeirsdottir, Helga, additional, Che, Karlhans, additional, Levänen, Bettina, additional, Lindén, Sara, additional, Jansson, Per-Anders, additional, Qvarfordt, Ingemar, additional, and Lindén, Anders, additional

Published
2019
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83. Glutamine and Alanine Metabolism in NIDDM

Author

Stumvoll, Michael, Perriello, Gabriele, Nurjhan, Nurjahan, Bucci, Arthur, Welle, Stephen, Jansson, Per-Anders, Dailey, George, Bier, Dennis, Jenssen, Trond, and Gerich, John

Published
1996

86. Effects of hyperglycemia on in vivo adipose tissue metabolism studied with microdialysis in IDDM subjects

Author

Merwe, Teresa M. van der, Eklund, Lars, Jansson, Per-Anders E., and Lonnroth, Peter N.

Subjects
Adipose tissues -- Physiological aspects, Type 1 diabetes -- Physiological aspects, Hyperglycemia -- Physiological aspects, Health, Physiological aspects
Abstract

The effect of hyperglycemia on in vivo adipose tissue metabolism was studied with microdialysis in seven lean patients with insulin-dependent diabetes mellitus (IDDM) receiving a constant infusion of insulin (36 [...]

Published
1994

87. Measurement by microdialysis of the insulin concentration in subcutaneous interstitial fluid: importance of the endothelial barrier for insulin

Author

Jansson, Per-Anders E., Fowelin, Jesper P., Schenck, Henning P. Von, Smith, Ulf P., and Lonnroth, Peter N.

Subjects
Insulin -- Physiological aspects, Health, Physiological aspects
Abstract

Importance of the Endothelial Barrier for Insulin To evaluate the interstitial insulin and inulin concentrations, 20-min microdialysis samples from the abdominal subcutaneous tissue were obtained by using two 45-mm polypropylene [...]

Published
1993

92. Metabolic effects of Lactobacillus reuteri DSM 17938 in people with type 2 diabetes:A randomized controlled trial

Author

Mobini, Reza, Tremaroli, Valentina, Ståhlman, Marcus, Karlsson, Fredrik, Levin, Max, Ljungberg, Maria, Sohlin, Maja, Bertéus Forslund, Heléne, Perkins, Rosie, Bäckhed, Gert Fredrik, Jansson, Per-Anders, Mobini, Reza, Tremaroli, Valentina, Ståhlman, Marcus, Karlsson, Fredrik, Levin, Max, Ljungberg, Maria, Sohlin, Maja, Bertéus Forslund, Heléne, Perkins, Rosie, Bäckhed, Gert Fredrik, and Jansson, Per-Anders

Abstract

AIMS: To investigate the metabolic effects of 12-week oral supplementation with Lactobacillus reuteri DSM 17938 in patients with type 2 diabetes on insulin therapy.MATERIALS AND METHODS: In a double-blind trial, we randomized 46 people with type 2 diabetes to placebo or a low (10(8) CFU/d) or high dose (10(10) CFU/d) of L. reuteri DSM 17938 for 12 weeks. The primary endpoint was the effect of supplementation on glycated haemoglobin (HbA1c). Secondary endpoints were insulin sensitivity (assessed by glucose clamp), liver fat content, body composition, body fat distribution, faecal microbiota composition and serum bile acids.RESULTS: Supplementation with L. reuteri DSM 17938 for 12 weeks did not affect HbA1c, liver steatosis, adiposity or microbiota composition. Participants who received the highest dose of L. reuteri exhibited increases in insulin sensitivity index (ISI) and serum levels of the secondary bile acid deoxycholic acid (DCA) compared with baseline, but these differences were not significant in the between-group analyses. Post hoc analysis showed that participants who responded with increased ISI after L. reuteri supplementation had higher microbial diversity at baseline, and increased serum levels of DCA after supplementation. In addition, increases in DCA levels correlated with improvement in insulin sensitivity in the probiotic recipients.CONCLUSIONS: Intake of L. reuteri DSM 17938 for 12 weeks did not affect HbA1c in people with type 2 diabetes on insulin therapy; however, L. reuteri improved insulin sensitivity in a subset of participants and we propose that high diversity of the gut microbiota at baseline may be important.

Published
2017

93. DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk

Author

Dayeh, Tasnim, Tuomi, Tiinamaija, Almgren, Peter, Perfilyev, Alexander, Jansson, Per-Anders, de Mello, Vanessa D., Pihlajamäki, Jussi, Vaag, Allan, Groop, Leif, Nilsson, Emma, Ling, Charlotte, Institute for Molecular Medicine Finland, Research Programs Unit, Clinicum, Tiinamaija Tuomi Research Group, Department of Medicine, and Diabetes and Obesity Research Program

Subjects
Adult, Male, ABCG1, GENES, endocrine system diseases, PHOSPHO1, METABOLISM, liver, Epigenesis, Genetic, DIFFERENTIAL EXPRESSION, blood, HUMAN PANCREATIC-ISLETS, VASCULAR CALCIFICATION, Humans, skeletal muscle, Muscle, Skeletal, ATP Binding Cassette Transporter, Subfamily G, Member 1, EPIGENOME-WIDE ASSOCIATION, DNA methylation, pancreatic islets, epigenetics, nutritional and metabolic diseases, DNA, Twins, Monozygotic, Middle Aged, Phosphoric Monoester Hydrolases, adipose tissue, ADIPOSE-TISSUE, Diabetes Mellitus, Type 2, Case-Control Studies, SKELETAL-MUSCLE, 1182 Biochemistry, cell and molecular biology, Female, LIFE-STYLE, type 2 diabetes, GLUCOSE-TOLERANCE, 3111 Biomedicine, Biomarkers, Research Paper
Abstract

Identification of subjects with a high risk of developing type 2 diabetes (T2D) is fundamental for prevention of the disease. Consequently, it is essential to search for new biomarkers that can improve the prediction of T2D. The aim of this study was to examine whether 5 DNA methylation loci in blood DNA (ABCG1, PHOSPHO1, SOCS3, SREBF1, and TXNIP), recently reported to be associated with T2D, might predict future T2D in subjects from the Botnia prospective study. We also tested if these CpG sites exhibit altered DNA methylation in human pancreatic islets, liver, adipose tissue, and skeletal muscle from diabetic vs. non-diabetic subjects. DNA methylation at the ABCG1 locus cg06500161 in blood DNA was associated with an increased risk for future T2D (OR = 1.09, 95% CI = 1.02-1.16, P-value = 0.007, Q-value = 0.018), while DNA methylation at the PHOSPHO1 locus cg02650017 in blood DNA was associated with a decreased risk for future T2D (OR = 0.85, 95% CI = 0.75-0.95, P-value = 0.006, Q-value = 0.018) after adjustment for age, gender, fasting glucose, and family relation. Furthermore, the level of DNA methylation at the ABCG1 locus cg06500161 in blood DNA correlated positively with BMI, HbA1c, fasting insulin, and triglyceride levels, and was increased in adipose tissue and blood from the diabetic twin among monozygotic twin pairs discordant for T2D. DNA methylation at the PHOSPHO1 locus cg02650017 in blood correlated positively with HDL levels, and was decreased in skeletal muscle from diabetic vs. non-diabetic monozygotic twins. DNA methylation of cg18181703 (SOCS3), cg11024682 (SREBF1), and cg19693031 (TXNIP) was not associated with future T2D risk in subjects from the Botnia prospective study.

Published
2016

94. Effects of free omega-3 carboxylic acids and fenofibrate on liver steatosis and serum lipoproteins in overweight patients with hypertriglyceridemia and non-alcoholic fatty liver disease (NAFLD)

Author

Lind, Lars, primary, Önnerhag, Kristina, additional, Riserus, Ulf, additional, Kvarnström, Mats, additional, Johansson, Lars, additional, Jansson, Per-Anders, additional, Moris, Linda, additional, Nilsson, Peter, additional, Eriksson, Jan W., additional, and Oscarsson, Jan, additional

Published
2017
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95. Statement of Retraction. The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes. Diabetes 2010;59:1870–1878. DOI: 10.2337/db09-1503. PMID: 20460426

Author

Boström, Pontus, primary, Andersson, Linda, additional, Vind, Birgitte, additional, Håversen, Liliana, additional, Rutberg, Mikael, additional, Wickström, Ylva, additional, Larsson, Erik, additional, Jansson, Per-Anders, additional, Svensson, Maria K., additional, Brånemark, Richard, additional, Ling, Charlotte, additional, Beck-Nielsen, Henning, additional, Borén, Jan, additional, Højlund, Kurt, additional, and Olofsson, Sven-Olof, additional

Published
2017
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96. Metabolic effects ofLactobacillus reuteriDSM 17938 in people with type 2 diabetes: A randomized controlled trial

Author

Mobini, Reza, primary, Tremaroli, Valentina, additional, Ståhlman, Marcus, additional, Karlsson, Fredrik, additional, Levin, Max, additional, Ljungberg, Maria, additional, Sohlin, Maja, additional, Bertéus Forslund, Heléne, additional, Perkins, Rosie, additional, Bäckhed, Fredrik, additional, and Jansson, Per-Anders, additional

Published
2017
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97. Effects of dapagliflozin, a sodium-glucose co-transporter 2 inhibitor, and free omega-3 carboxylic acids on liver steatosis and hepatocyte damage biomarkers in Type 2 diabetes patients with non-alcoholic fatty liver disease

Author

Oscarsson, Jan, Lundkvist, Per, Jansson, Per-Anders E., Johansson, Lars, Kvarnström, Mats, Moris, Linda, Risérus, Ulf, Lind, Lars, Eriksson, Jan W., Oscarsson, Jan, Lundkvist, Per, Jansson, Per-Anders E., Johansson, Lars, Kvarnström, Mats, Moris, Linda, Risérus, Ulf, Lind, Lars, and Eriksson, Jan W.

Published
2016

98. A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits

Author

Volkov, Petr, primary, Olsson, Anders H., additional, Gillberg, Linn, additional, Jørgensen, Sine W., additional, Brøns, Charlotte, additional, Eriksson, Karl-Fredrik, additional, Groop, Leif, additional, Jansson, Per-Anders, additional, Nilsson, Emma, additional, Rönn, Tina, additional, Vaag, Allan, additional, and Ling, Charlotte, additional

Published
2016
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100. Circulating concentrations of endothelin-1 predict coronary heart disease in women but not in men: a longitudinal observational study in the Vara-Skövde Cohort.

Author

Daka, Bledar, Olausson, Josefin, Larsson, Charlotte A, Hellgren, Margareta I, Råstam, Lennart, Jansson, Per-Anders, Lindblad, Ulf, Daka, Bledar, Olausson, Josefin, Larsson, Charlotte A, Hellgren, Margareta I, Råstam, Lennart, Jansson, Per-Anders, and Lindblad, Ulf

Abstract

The vasoconstricting peptide endothelin-1 has been proposed to be a marker of cardiovascular disease. Our aim was to investigate whether circulating endothelin-1 levels predict coronary heart disease (CHD) in Sweden.

Published
2015

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