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52. Ionized Magnesium: Interpretation and Interest in Atrial Fibrillation

Author

Bouillon-Minois, Jean-Baptiste, primary, Khaled, Louisa, additional, Vitte, Florence, additional, Miraillet, Ludovic, additional, Eschalier, Romain, additional, Jabaudon, Matthieu, additional, Sapin, Vincent, additional, Derault, Lucas, additional, Kahouadji, Samy, additional, Brailova, Marina, additional, Durif, Julie, additional, Schmidt, Jeannot, additional, Moustafa, Fares, additional, Pereira, Bruno, additional, Futier, Emmanuel, additional, and Bouvier, Damien, additional

Published
2023
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56. Inhaled Sedation in Patients with COVID-19-Related Acute Respiratory Distress Syndrome: An International Retrospective Study

Author

Coupet, Randy, primary, Schläpfer, Martin, additional, Neff, Thomas A., additional, Boucher, Pierre, additional, Bailly, Pierre, additional, Bellgardt, Martin, additional, Badenes, Rafael, additional, Carbonell, Jose, additional, Becher, Tobias, additional, Varillon, Caroline, additional, Morand, Dominique, additional, Blondonnet, Raiko, additional, Constantin, Jean-Michel, additional, Pereira, Bruno, additional, O'Gara, Brian, additional, and Jabaudon, Matthieu, additional

Published
2022
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58. Additional file 3 of Thoracic epidural analgesia in intensive care unit patients with acute pancreatitis: the EPIPAN multicenter randomized controlled trial

Author

Jabaudon, Matthieu, Genevrier, Alexandra, Jaber, Samir, Windisch, Olivier, Bulyez, Stéphanie, Laterre, Pierre-François, Escudier, Etienne, Sossou, Achille, Guerci, Philippe, Bertrand, Pierre-Marie, Danin, Pierre-Eric, Bonnassieux, Martin, Bühler, Leo, Heidegger, Claudia Paula, Chabanne, Russell, Godet, Thomas, Roszyk, Laurence, Sapin, Vincent, Futier, Emmanuel, Pereira, Bruno, and Constantin, Jean-Michel

Abstract

Additional file 3. CONSORT checklist.

Published
2023
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59. Additional file 2 of Thoracic epidural analgesia in intensive care unit patients with acute pancreatitis: the EPIPAN multicenter randomized controlled trial

Author

Jabaudon, Matthieu, Genevrier, Alexandra, Jaber, Samir, Windisch, Olivier, Bulyez, Stéphanie, Laterre, Pierre-François, Escudier, Etienne, Sossou, Achille, Guerci, Philippe, Bertrand, Pierre-Marie, Danin, Pierre-Eric, Bonnassieux, Martin, Bühler, Leo, Heidegger, Claudia Paula, Chabanne, Russell, Godet, Thomas, Roszyk, Laurence, Sapin, Vincent, Futier, Emmanuel, Pereira, Bruno, and Constantin, Jean-Michel

Abstract

Additional file 2. Research protocols and analysis plans.

Published
2023
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60. Additional file 1 of Thoracic epidural analgesia in intensive care unit patients with acute pancreatitis: the EPIPAN multicenter randomized controlled trial

Author

Jabaudon, Matthieu, Genevrier, Alexandra, Jaber, Samir, Windisch, Olivier, Bulyez, Stéphanie, Laterre, Pierre-François, Escudier, Etienne, Sossou, Achille, Guerci, Philippe, Bertrand, Pierre-Marie, Danin, Pierre-Eric, Bonnassieux, Martin, Bühler, Leo, Heidegger, Claudia Paula, Chabanne, Russell, Godet, Thomas, Roszyk, Laurence, Sapin, Vincent, Futier, Emmanuel, Pereira, Bruno, and Constantin, Jean-Michel

Abstract

Additional file 1. List of investigators and additional details.

Published
2023
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61. Receptor for Advanced Glycation End-Products Promotes Activation of Alveolar Macrophages through the NLRP3 Inflammasome/TXNIP Axis in Acute Lung Injury

Author

Lenga Ma Bonda, Woodys, primary, Fournet, Marianne, additional, Zhai, Ruoyang, additional, Lutz, Jean, additional, Blondonnet, Raiko, additional, Bourgne, Céline, additional, Leclaire, Charlotte, additional, Saint-Béat, Cécile, additional, Theilliere, Camille, additional, Belville, Corinne, additional, Bouvier, Damien, additional, Blanchon, Loïc, additional, Berger, Marc, additional, Sapin, Vincent, additional, and Jabaudon, Matthieu, additional

Published
2022
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64. Thoracic Epidural Analgesia and Mortality in Acute Pancreatitis: A Multicenter Propensity Analysis

Author

Jabaudon, Matthieu, Belhadj-Tahar, Nouria, Rimmelé, Thomas, Joannes-Boyau, Olivier, Bulyez, Stéphanie, Lefrant, Jean-Yves, Malledant, Yannick, Leone, Marc, Abback, Paer-Selim, Tamion, Fabienne, Dupont, Hervé, Lortat-Jacob, Brice, Guerci, Philippe, Kerforne, Thomas, Cinotti, Raphael, Jacob, Laurent, Verdier, Philippe, Dugernier, Thierry, Pereira, Bruno, and Constantin, Jean-Michel

Published
2018
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65. Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome.

Author

Zhai, Ruoyang, Lenga Ma Bonda, Woodys, Leclaire, Charlotte, Saint-Béat, Cécile, Theilliere, Camille, Belville, Corinne, Coupet, Randy, Blondonnet, Raiko, Bouvier, Damien, Blanchon, Loic, Sapin, Vincent, and Jabaudon, Matthieu

Subjects
LUNGS, ADULT respiratory distress syndrome, CYTOSKELETAL proteins, SEVOFLURANE, ADVANCED glycation end-products, PERMEABILITY
Abstract

Background: Preclinical studies in acute respiratory distress syndrome (ARDS) have suggested that inhaled sevoflurane may have lung-protective effects and clinical trials are ongoing to assess its impact on major clinical outcomes in patients with ARDS. However, the underlying mechanisms of these potential benefits are largely unknown. This investigation focused on the effects of sevoflurane on lung permeability changes after sterile injury and the possible associated mechanisms. Methods: To investigate whether sevoflurane could decrease lung alveolar epithelial permeability through the Ras homolog family member A (RhoA)/phospho-Myosin Light Chain 2 (Ser19) (pMLC)/filamentous (F)-actin pathway and whether the receptor for advanced glycation end-products (RAGE) may mediate these effects. Lung permeability was assessed in RAGE−/− and littermate wild-type C57BL/6JRj mice on days 0, 1, 2, and 4 after acid injury, alone or followed by exposure at 1% sevoflurane. Cell permeability of mouse lung epithelial cells was assessed after treatment with cytomix (a mixture of TNFɑ, IL-1β, and IFNγ) and/or RAGE antagonist peptide (RAP), alone or followed by exposure at 1% sevoflurane. Levels of zonula occludens-1, E-cadherin, and pMLC were quantified, along with F-actin immunostaining, in both models. RhoA activity was assessed in vitro. Results: In mice after acid injury, sevoflurane was associated with better arterial oxygenation, decreased alveolar inflammation and histological damage, and non-significantly attenuated the increase in lung permeability. Preserved protein expression of zonula occludens-1 and less increase of pMLC and actin cytoskeletal rearrangement were observed in injured mice treated with sevoflurane. In vitro, sevoflurane markedly decreased electrical resistance and cytokine release of MLE-12 cells, which was associated with higher protein expression of zonula occludens-1. Improved oxygenation levels and attenuated increase in lung permeability and inflammatory response were observed in RAGE−/− mice compared to wild-type mice, but RAGE deletion did not influence the effects of sevoflurane on permeability indices after injury. However, the beneficial effect of sevoflurane previously observed in wild-type mice on day 1 after injury in terms of higher PaO2/FiO2 and decreased alveolar levels of cytokines was not found in RAGE−/− mice. In vitro, RAP alleviated some of the beneficial effects of sevoflurane on electrical resistance and cytoskeletal rearrangement, which was associated with decreased cytomix-induced RhoA activity. Conclusions: Sevoflurane decreased injury and restored epithelial barrier function in two in vivo and in vitro models of sterile lung injury, which was associated with increased expression of junction proteins and decreased actin cytoskeletal rearrangement. In vitro findings suggest that sevoflurane may decrease lung epithelial permeability through the RhoA/pMLC/F-actin pathway. [ABSTRACT FROM AUTHOR]

Published
2023
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68. Inhaled Sedation in Patients with COVID-19-Related Acute Respiratory Distress Syndrome: An International Retrospective Study

Author

Coupet, Randy; https://orcid.org/0000-0002-6314-5827, Schläpfer, Martin; https://orcid.org/0000-0003-4288-7124, Neff, Thomas A, Boucher, Pierre, Bailly, Pierre, Bellgardt, Martin; https://orcid.org/0000-0001-9447-0019, Badenes, Rafael; https://orcid.org/0000-0001-7017-0150, Carbonell, Jose; https://orcid.org/0000-0001-7837-3868, Becher, Tobias, Varillon, Caroline, Morand, Dominique, Blondonnet, Raiko; https://orcid.org/0000-0001-9881-8422, Constantin, Jean-Michel, Pereira, Bruno; https://orcid.org/0000-0003-3778-7161, O'Gara, Brian, Jabaudon, Matthieu; https://orcid.org/0000-0002-8121-1680, Coupet, Randy; https://orcid.org/0000-0002-6314-5827, Schläpfer, Martin; https://orcid.org/0000-0003-4288-7124, Neff, Thomas A, Boucher, Pierre, Bailly, Pierre, Bellgardt, Martin; https://orcid.org/0000-0001-9447-0019, Badenes, Rafael; https://orcid.org/0000-0001-7017-0150, Carbonell, Jose; https://orcid.org/0000-0001-7837-3868, Becher, Tobias, Varillon, Caroline, Morand, Dominique, Blondonnet, Raiko; https://orcid.org/0000-0001-9881-8422, Constantin, Jean-Michel, Pereira, Bruno; https://orcid.org/0000-0003-3778-7161, O'Gara, Brian, and Jabaudon, Matthieu; https://orcid.org/0000-0002-8121-1680

Abstract

Background and objectives: The coronavirus disease 2019 (COVID-19) pandemic and the shortage of intravenous sedatives has led to renewed interest in inhaled sedation for patients with acute respiratory distress syndrome (ARDS). We hypothesized that inhaled sedation would be associated with improved clinical outcomes in COVID-19 ARDS patients. Methods: Retrospective international study including mechanically ventilated patients with COVID-19 ARDS who required sedation and were admitted to 10 European and US intensive care units. The primary endpoint of ventilator-free days through day 28 was analyzed using zero-inflated negative binomial regression, before and after adjustment for site, clinically relevant covariates determined according to the univariate results, and propensity score matching. Results: A total of 196 patients were enrolled, 78 of whom died within 28 days. The number of ventilator-free days through day 28 did not differ significantly between the patients who received inhaled sedation for at least 24 h (n = 111) and those who received intravenous sedation only (n = 85), with medians of 0 (interquartile range [IQR] 0–8) and 0 (IQR 0–17), respectively (odds ratio for having zero ventilator-free days through day 28, 1.63, 95% confidence interval [CI], 0.91–2.92, p = 0.10). The incidence rate ratio for the number of ventilator-free days through day 28 if not 0 was 1.13 (95% CI, 0.84–1.52, p = 0.40). Similar results were found after multivariable adjustment and propensity matching. Conclusion: The use of inhaled sedation in COVID-19 ARDS was not associated with the number of ventilator-free days through day 28. Keywords: coronavirus disease 2019; acute respiratory distress syndrome; inhaled sedation; sevoflurane; isoflurane

Published
2022

70. Modulation by Polymyxin-B Hemoperfusion of Inflammatory Response Related to Severe Peritonitis

Author

Coudroy, Rémi, Payen, Didier, Launey, Yoann, Lukaszewicz, Anne-Claire, Kaaki, Mahmoud, Veber, Benoit, Collange, Olivier, Dewitte, Antoine, Martin-Lefevre, Laurent, Jabaudon, Matthieu, Kerforne, Thomas, Ferrandière, Martine, Kipnis, Eric, Vela, Carlos, Chevalier, Stéphanie, Mallat, Jihad, Charreau, Sandrine, Lecron, Jean-Claude, and Robert, René

Published
2017
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71. Effects of a recruitment maneuver on plasma levels of soluble RAGE in patients with diffuse acute respiratory distress syndrome: a prospective randomized crossover study

Author

Jabaudon, Matthieu, Hamroun, Nacim, Roszyk, Laurence, Guérin, Renaud, Bazin, Jean-Etienne, Sapin, Vincent, and Pereira, Bruno

Subjects
Medical research, Medicine, Experimental, Respiratory distress syndrome -- Care and treatment, Acute respiratory distress syndrome -- Care and treatment, Cisatracurium, Health care industry
Abstract

Purpose The soluble form of the receptor for advanced glycation end-products (sRAGE) is a promising marker for epithelial dysfunction, but it has not been fully characterized as a biomarker of acute respiratory distress syndrome (ARDS). Whether sRAGE could inform on the response to ventilator settings has been poorly investigated, and whether a recruitment maneuver (RM) may influence plasma sRAGE remains unknown. Methods Twenty-four patients with moderate/severe, nonfocal ARDS were enrolled in this prospective monocentric crossover study and randomized into a 'RM-SHAM' group when a 6-h-long RM sequence preceded a 6-h-long sham evaluation period, or a 'SHAM-RM' group (inverted sequences). Protective ventilation was applied, and RM consisted of the application of 40 cmH.sub.2O airway pressure for 40 s. Arterial blood was sampled for gas analyses and sRAGE measurements, 5 min pre-RM (or 40-s-long sham period), 5, 30 min, 1, 4, and 6 h after the RM (or 40-s-long sham period). Results Mean PaO.sub.2/FiO.sub.2, tidal volume, PEEP, and plateau pressure were 125 mmHg, 6.8 ml/kg (ideal body weight), and 13 and 26 cmH.sub.2O, respectively. Median baseline plasma sRAGE levels were 3,232 pg/ml. RM induced a significant decrease in sRAGE (-1,598 ± 859 pg/ml) in 1 h (p = 0.043). At 4 and 6 h post-RM, sRAGE levels increased back toward baseline values. Pre-RM sRAGE was associated with RM-induced oxygenation improvement (AUC 0.84). Conclusions We report the first kinetics study of plasma sRAGE after RM in ARDS. Our findings reinforce the value of plasma sRAGE as a biomarker of ARDS., Author(s): Matthieu Jabaudon [sup.1] [sup.2], Nacim Hamroun [sup.1], Laurence Roszyk [sup.2] [sup.3], Renaud Guérin [sup.1], Jean-Etienne Bazin [sup.1], Vincent Sapin [sup.2] [sup.3], Bruno Pereira [sup.4], Jean-Michel Constantin [sup.1] [sup.2] Author [...]

Published
2015
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72. Early use of polymyxin B hemoperfusion in patients with septic shock due to peritonitis: a multicenter randomized control trial

Author

Payen, Didier M., Guilhot, Joelle, Launey, Yoann, Lukaszewicz, Anne Claire, Kaaki, Mahmoud, Veber, Benoit, Pottecher, Julien, Joannes-Boyau, Olivier, Martin-Lefevre, Laurent, Jabaudon, Matthieu, Mimoz, Olivier, Coudroy, Rémi, Ferrandière, Martine, Kipnis, Eric, Vela, Carlos, Chevallier, Stéphanie, Mallat, Jihad, Robert, René, and The ABDOMIX Group

Published
2015
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75. Inhaled Sedation in Patients with COVID-19-Related Acute Respiratory Distress Syndrome: An International Retrospective Study

Author

Coupet, Randy, Schläpfer, Martin, Neff, Thomas A, Boucher, Pierre, Bailly, Pierre, Bellgardt, Martin, Badenes, Rafael, Carbonell, Jose, Becher, Tobias, Varillon, Caroline, Morand, Dominique, Blondonnet, Raiko, Constantin, Jean-Michel, Pereira, Bruno, O'Gara, Brian, Jabaudon, Matthieu, and University of Zurich

Subjects
10216 Institute of Anesthesiology, coronavirus disease 2019, acute respiratory distress syndrome, inhaled sedation, sevoflurane, isoflurane, 610 Medicine & health, General Medicine, 10052 Institute of Physiology
Abstract

Background and objectives: The coronavirus disease 2019 (COVID-19) pandemic and the shortage of intravenous sedatives has led to renewed interest in inhaled sedation for patients with acute respiratory distress syndrome (ARDS). We hypothesized that inhaled sedation would be associated with improved clinical outcomes in COVID-19 ARDS patients. Methods: Retrospective international study including mechanically ventilated patients with COVID-19 ARDS who required sedation and were admitted to 10 European and US intensive care units. The primary endpoint of ventilator-free days through day 28 was analyzed using zero-inflated negative binomial regression, before and after adjustment for site, clinically relevant covariates determined according to the univariate results, and propensity score matching. Results: A total of 196 patients were enrolled, 78 of whom died within 28 days. The number of ventilator-free days through day 28 did not differ significantly between the patients who received inhaled sedation for at least 24 h (n = 111) and those who received intravenous sedation only (n = 85), with medians of 0 (interquartile range [IQR] 0–8) and 0 (IQR 0–17), respectively (odds ratio for having zero ventilator-free days through day 28, 1.63, 95% confidence interval [CI], 0.91–2.92, p = 0.10). The incidence rate ratio for the number of ventilator-free days through day 28 if not 0 was 1.13 (95% CI, 0.84–1.52, p = 0.40). Similar results were found after multivariable adjustment and propensity matching. Conclusion: The use of inhaled sedation in COVID-19 ARDS was not associated with the number of ventilator-free days through day 28.

Published
2022
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76. In Response

Author

Blondonnet, Raiko, primary, Begard, Marc, additional, Bouzat, Pierre, additional, and Jabaudon, Matthieu, additional

Published
2021
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78. Inhaled Sedation in Patients with COVID-19-Related Acute Respiratory Distress Syndrome: An International Retrospective Study †.

Author

Coupet, Randy, Schläpfer, Martin, Neff, Thomas A., Boucher, Pierre, Bailly, Pierre, Bellgardt, Martin, Badenes, Rafael, Carbonell, Jose, Becher, Tobias, Varillon, Caroline, Morand, Dominique, Blondonnet, Raiko, Constantin, Jean-Michel, Pereira, Bruno, O'Gara, Brian, and Jabaudon, Matthieu

Subjects
ADULT respiratory distress syndrome, COVID-19, PROPENSITY score matching, INTENSIVE care units, CONSCIOUS sedation
Abstract

Background and objectives: The coronavirus disease 2019 (COVID-19) pandemic and the shortage of intravenous sedatives has led to renewed interest in inhaled sedation for patients with acute respiratory distress syndrome (ARDS). We hypothesized that inhaled sedation would be associated with improved clinical outcomes in COVID-19 ARDS patients. Methods: Retrospective international study including mechanically ventilated patients with COVID-19 ARDS who required sedation and were admitted to 10 European and US intensive care units. The primary endpoint of ventilator-free days through day 28 was analyzed using zero-inflated negative binomial regression, before and after adjustment for site, clinically relevant covariates determined according to the univariate results, and propensity score matching. Results: A total of 196 patients were enrolled, 78 of whom died within 28 days. The number of ventilator-free days through day 28 did not differ significantly between the patients who received inhaled sedation for at least 24 h (n = 111) and those who received intravenous sedation only (n = 85), with medians of 0 (interquartile range [IQR] 0–8) and 0 (IQR 0–17), respectively (odds ratio for having zero ventilator-free days through day 28, 1.63, 95% confidence interval [CI], 0.91–2.92, p = 0.10). The incidence rate ratio for the number of ventilator-free days through day 28 if not 0 was 1.13 (95% CI, 0.84–1.52, p = 0.40). Similar results were found after multivariable adjustment and propensity matching. Conclusion: The use of inhaled sedation in COVID-19 ARDS was not associated with the number of ventilator-free days through day 28. [ABSTRACT FROM AUTHOR]

Published
2023
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79. Impact of Air Transport on SpO2/FiO2 among Critical COVID-19 Patients during the First Pandemic Wave in France

Author

Bouillon-Minois, Jean-Baptiste, primary, Roux, Vincent, additional, Jabaudon, Matthieu, additional, Flannery, Mara, additional, Duchenne, Jonathan, additional, Dumesnil, Maxime, additional, Paillard-Turenne, Morgane, additional, Gendre, Paul-Henri, additional, Grapin, Kévin, additional, Rieu, Benjamin, additional, Dutheil, Frédéric, additional, Croizier, Carolyne, additional, Schmidt, Jeannot, additional, and Pereira, Bruno, additional

Published
2021
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80. Le Collège National des Enseignants d’Anesthésie et de Réanimation (CNEAR)

Author

Bouzat, Pierre, primary, Bougle, Adrien, additional, Jabaudon, Matthieu, additional, Dureuil, Bertrand, additional, Gayat, Etienne, additional, Bounes, Fanny, additional, Clavier, Thomas, additional, Besch, Guillaume, additional, Chanques, Gérald, additional, Fischer, Marc-Olivier, additional, Frasca, Denis, additional, Orliaguet, Gilles, additional, Raux, Mathieu, additional, Samain, Emmanuel, additional, Tran-Dinh, Alexy, additional, Plaud, Benoît, additional, Velly, Lionel, additional, Veber, Benoît, additional, and Pottecher, Julien, additional

Published
2021
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81. Decision support system to evaluate VENTilation in the Acute Respiratory Distress Syndrome (DeVENT study) – Trial Protocol

Author

Patel, Brijesh, primary, Mumby, Sharon, additional, Johnson, Nicholas, additional, Falaschetti, Emanuela, additional, Hansen, Jorgen, additional, Adcock, Ian, additional, McAuley, Danny, additional, Takata, Masao, additional, Karbing, Dan S., additional, Jabaudon, Matthieu, additional, Schellengowski, Peter, additional, and Rees, Stephen E., additional

Published
2021
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84. Importance of Lung Epithelial Injury in COVID-19–associated Acute Respiratory Distress Syndrome: Value of Plasma Soluble Receptor for Advanced Glycation End-Products

Author

Kapandji, Natacha, primary, Yvin, Elise, additional, Devriese, Magali, additional, de Margerie-Mellon, Constance, additional, Moratelli, Giulia, additional, Lemiale, Virginie, additional, Jabaudon, Matthieu, additional, Azoulay, Elie, additional, Constantin, Jean-Michel, additional, and Dumas, Guillaume, additional

Published
2021
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87. Blunt Chest Trauma and Regional Anesthesia for Analgesia of Multitrauma Patients in French Intensive Care Units: A National Survey

Author

Blondonnet, Raiko, primary, Begard, Marc, additional, Jabaudon, Matthieu, additional, Godet, Thomas, additional, Rieu, Benjamin, additional, Audard, Jules, additional, Lagarde, Kevin, additional, Futier, Emmanuel, additional, Pereira, Bruno, additional, Bouzat, Pierre, additional, and Constantin, Jean-Michel, additional

Published
2021
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88. Early Changes over Time in the Radiographic Assessment of Lung Edema (RALE) Score are Associated with Survival in Acute Respiratory Distress Syndrome

Author

Jabaudon, Matthieu, Audard, Jules, Pereira, Bruno, Jaber, Samir, Lefrant, Jean-Yves, Blondonnet, Raiko, Godet, Thomas, Futier, Emmanuel, Lambert, Celine, Bazin, Jean-Etienne, Bastarache, Julie, Constantin, Jean-Michel, Ware, Lorraine, Group, Live Study, Network, Azurea Collaborative, CHU Clermont-Ferrand, Université de Clermont-Ferrand, Unité de Biostatistiques [CHU Clermont-Ferrand], Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Retinoids, Development and Developmental Diseases (R2D2), Université d'Auvergne - Clermont-Ferrand I (UdA), Service d'Anésthésie Réanimation [CHU Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], Unité Biostatistique, Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine [Nashville], Génétique, Reproduction et Développement (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Vanderbilt University Medical Center [Nashville], Vanderbilt University [Nashville], and MORNET, Dominique

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Survival, [SDV]Life Sciences [q-bio], ARDS, Radiographic score, Treatable trait, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; Background: The Radiographic Assessment of Lung Edema (RALE) score is associated with the severity of ARDS, and treatments targeted at reducing pulmonary edema such as conservative fluid management cause a reduction in RALE score over time.Research question: Are early changes in RALE score over time associated with survival in patients with ARDS?Study design and methods: Data from patients enrolled in three centers in the Lung Imaging for Ventilation sEtting in ARDS (LIVE) trial with available chest radiographs at baseline (day 0) and days 2 or 3 were used. The RALE was scored by two independent reviewers. The primary end point was death by day 90, considering RALE score both at baseline and as a time-varying covariate in a marginal Cox survival model.Results: RALE was scored from 135, 64, and 88 radiographs on days 0, 2, and 3, respectively. Both baseline RALE (hazard ratio [HR] for each one-point increment, 1.04; 95% CI, 1.01-1.08; P = .006) and the change in RALE over time (HR for each one-point decrease per unit of time, 0.99; 95% CI, 0.99-0.99; P = .03) were associated with death by day 90, even after adjustment for age, sex, BMI, Simplified Acute Physiology Score II, vasopressor use, and total volume of fluids received since study entry.Interpretation: The change in RALE during the first days after ARDS onset is independently associated with survival and may be useful as a surrogate end point in future clinical trials of new therapeutics in ARDS.

Published
2020

89. Additional file 2 of Epidural analgesia in ICU chest trauma patients with fractured ribs: retrospective study of pain control and intubation requirements

Author

Bachoumas, Konstantinos, Albrice Levrat, Thuaut, Aurélie Le, Rouleau, Stéphane, Groyer, Samuel, Dupont, Hervé, Rooze, Paul, Eisenmann, Nathanael, Trampont, Timothée, Bohé, Julien, Rieu, Benjamin, Jean-Charles Chakarian, Godard, Aurélie, Frederici, Laura, Gélinotte, Stephanie, Joret, Aurélie, Roques, Pascale, Benoit Painvin, Leroy, Christophe, Benedit, Marcel, Loic Dopeux, Soum, Edouard, Botoc, Vlad, Fartoukh, Muriel, Marie-Hélène Hausermann, Kamel, Toufik, Morin, Jean, Varax, Roland De, Plantefève, Gaetan, Herbland, Alexandre, Jabaudon, Matthieu, Duburcq, Thibault, Simon, Christelle, Chabanne, Russell, Schneider, Francis, Ganster, Frederique, Bruel, Cedric, Ahmed-Saïd Laggoune, Bregeaud, Delphine, Souweine, Bertrand, Reignier, Jean, and Lascarrou, Jean-Baptiste

Abstract

Additional file 2: Figure S2. Proportions of patients given epidural analgesia in each study ICU.

Published
2020
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90. Additional file 4 of Epidural analgesia in ICU chest trauma patients with fractured ribs: retrospective study of pain control and intubation requirements

Author

Bachoumas, Konstantinos, Albrice Levrat, Thuaut, Aurélie Le, Rouleau, Stéphane, Groyer, Samuel, Dupont, Hervé, Rooze, Paul, Eisenmann, Nathanael, Trampont, Timothée, Bohé, Julien, Rieu, Benjamin, Jean-Charles Chakarian, Godard, Aurélie, Frederici, Laura, Gélinotte, Stephanie, Joret, Aurélie, Roques, Pascale, Benoit Painvin, Leroy, Christophe, Benedit, Marcel, Loic Dopeux, Soum, Edouard, Botoc, Vlad, Fartoukh, Muriel, Marie-Hélène Hausermann, Kamel, Toufik, Morin, Jean, Varax, Roland De, Plantefève, Gaetan, Herbland, Alexandre, Jabaudon, Matthieu, Duburcq, Thibault, Simon, Christelle, Chabanne, Russell, Schneider, Francis, Ganster, Frederique, Bruel, Cedric, Ahmed-Saïd Laggoune, Bregeaud, Delphine, Souweine, Bertrand, Reignier, Jean, and Lascarrou, Jean-Baptiste

Subjects
human activities, humanities
Abstract

Additional file 4: Table S2. Sensitivity analysis restricted to the 327 patients with an NRS pain score > 3 on ICU day 1.

Published
2020
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91. Additional file 3 of Epidural analgesia in ICU chest trauma patients with fractured ribs: retrospective study of pain control and intubation requirements

Author

Bachoumas, Konstantinos, Albrice Levrat, Thuaut, Aurélie Le, Rouleau, Stéphane, Groyer, Samuel, Dupont, Hervé, Rooze, Paul, Eisenmann, Nathanael, Trampont, Timothée, Bohé, Julien, Rieu, Benjamin, Jean-Charles Chakarian, Godard, Aurélie, Frederici, Laura, Gélinotte, Stephanie, Joret, Aurélie, Roques, Pascale, Benoit Painvin, Leroy, Christophe, Benedit, Marcel, Loic Dopeux, Soum, Edouard, Botoc, Vlad, Fartoukh, Muriel, Marie-Hélène Hausermann, Kamel, Toufik, Morin, Jean, Varax, Roland De, Plantefève, Gaetan, Herbland, Alexandre, Jabaudon, Matthieu, Duburcq, Thibault, Simon, Christelle, Chabanne, Russell, Schneider, Francis, Ganster, Frederique, Bruel, Cedric, Ahmed-Saïd Laggoune, Bregeaud, Delphine, Souweine, Bertrand, Reignier, Jean, and Lascarrou, Jean-Baptiste

Abstract

Additional file 3: Table S1. Sensitivity analysis restricted to the 526 patients in ICUs where at least 1 study patient received epidural analgesia.

Published
2020
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92. Additional file 1 of Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis

Author

Carla, Adrien, Pereira, Bruno, Boukail, Hanifa, Audard, Jules, Pinol-Domenech, Nathalie, Carvalho, Manuela De, Blondonnet, Raiko, Ruoyang Zhai, Morand, Dominique, Lambert, Céline, Sapin, Vincent, Ware, Lorraine B., Calfee, Carolyn S., Bastarache, Julie A., Laffey, John G., Juffermans, Nicole P., Bos, Lieuwe D., Artigas, Antonio, Rocco, Patricia R. M., Matthay, Michael A., McAuley, Daniel F., Jean-Michel Constantin, and Jabaudon, Matthieu

Subjects
Data_FILES
Abstract

Additional file 1. Representative Search Strategy.

Published
2020
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93. Additional file 2 of Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis

Author

Carla, Adrien, Pereira, Bruno, Boukail, Hanifa, Audard, Jules, Pinol-Domenech, Nathalie, Carvalho, Manuela De, Blondonnet, Raiko, Ruoyang Zhai, Morand, Dominique, Lambert, Céline, Sapin, Vincent, Ware, Lorraine B., Calfee, Carolyn S., Bastarache, Julie A., Laffey, John G., Juffermans, Nicole P., Bos, Lieuwe D., Artigas, Antonio, Rocco, Patricia R. M., Matthay, Michael A., McAuley, Daniel F., Jean-Michel Constantin, and Jabaudon, Matthieu

Abstract

Additional file 2. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) checklist.

Published
2020
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94. Added value of serial bio-adrenomedullin measurement in addition to lactate for the prognosis of septic patients admitted to ICU

Author

Blet, Alice, De Roquetaillade, Charles, Hartmann, Oliver, Struck, Joachim, Mebazaa, Alexandre, Chousterman, Benjamin Glenn, Laterre, Pierre François, Berghe, Caroline, Dujardin, Marie France, Renard, Suzanne, Wittebole, Xavier, Collienne, Christine, Zapatero, Diego Castanares, Dugernier, Thierry, Vinetti, Marco, De Schryver, Nicolas, Thirifays, Anne, Mairesse, Jacques, Huberlant, Vincent, Petre, Hélène, Buelens, Isabelle, Henin, Pierre, Trine, Hugues, Laurent, Yves, Sébastien, Loix, Geukens, Paul, Kehl, Laurent, François, Bruno, Vignon, Philippe, Pichon, Nicolas, Begot, Emmanuelle, Fedou, Anne Laure, Chapellas, Catherine, Galy, Antoine, Rodier, Nicolas, Baudrillart, Ludmilla, Nouaille, Michelle, Laleu, Séverine, Mancia, Claire, Daix, Thomas, Bourzeix, Paul, Herafa, Isabelle, Duchambon, Anne Aurore, Lascarrou, Jean Baptiste, Fiancette, Maud, Colin, Gwenhael, Henry-Lagarrigue, Matthieu, Lacherade, Jean Claude, Lebert, Christine, Martin-Levfèvre, Laurent, Vinatier, Isabelle, Yehia, Aihem, Bachoumas, Konstantinos, Joret, Aurélie, Reignier, Jean, Rousseau, Cécille, Maquigneau, Natacha, Alcourt, Yolaine, Zinzonni, Vanessa Erragne, Deschamps, Angélique, Robert, Angelina, Mercier, Emmanuelle, Simeon-Vieules, Véronique, Aubrey, Aurélie, Mabilat, Christine, Garot, Denis, Ehrmann, Stephan, Legras, Annick, Jouan, Youenn, Dequin, Pierre François, Guillon, Antoine, Bodet-Contentin, Laetitia, Rouve, Emmannuelle, Salmon, Charlotte, Brick, Lysiane, Massat, Stéphanie, Desachy, Arnaud, Fally, Marie Anne, Robin, Laurence, Cracco, Christophe, Lafon, Charles, Calvat, Sylvie, Rouleau, Stéphane, Schnell, David, Lasocki, Sigismond, Fesard, Philippe, Leblanc, Damien, Bouhours, Guillaume, Chassier, Claire, Conte, Mathieu, Gaillard, Thomas, Denou, Floriane, Kerymel, Mathieu, Guyon, Marion, Loiez, Anthéa, Lebreton, Stéphanie, Meziani, Ferhat, Allam, Hayat, Chenaf, Samir, Rahmani, Hassène, Heenen, Sarah, Kummerlen, Christine, Delabranche, Xavier, Boivin, Alexandra, Clere-Jehl, Raphaël, Rabouël, Yannick, Pottecher, Julien, Bayer, Sophie, Metzger, Catherine, Hecketsweiler, Stéphane, Ludes, Pierre Olivier, Besancenot, Hortense, Dhif, Nadia, Freys, Guy, Lessinger, Jean Marc, Launoy, Anne, Ruimy, Aude, Meyer, Alain, Szozot, M., Deye, Nicolas, Gayat, Etienne, Fournier, Marie Céline, Abroug, Sarra, Louadah, Badr, Feliot, Elodie, Voicu, Sebastian, Malissin, Isabelle, Megarbane, Bruno, Manivet, Philippe, Victori, Gardianot, Kelly, Da Silva, La Foucher, Béatrice, Pierre, Valérie, Kerdjana, Lamia, Beeken, Thomas, Goury, Antoine, Garcon, Pierre, Gaugain, Samuel, Huot, Benjamin, Barthelemy, Romain, Soyer, Benjamin, Jacob, Laurent, Legrand, Matthieu, Fourniar, Marie Céline, Bonnet, Francine, Legall, Chloé, Oueslati, Haikel, Cupaciu, Alexandru, Manivat, Philippe, Louadeh, Badr, Sonneville, Romain, Letrou, Sophie, Bouadma, Lila, Mourvillier, Bruno, Deiler, Véronique, Magalhaes, Eric, Neuville, Mathilde, Timsit, Jean François, Radjou, Aguila, Gaudry, Stéphane, Dubief, Emeline, Messika, Jonathan, La Combe, Béatrice, Roux, Damien, Berquier, Guillaume, Laissi, Mohamed, Ricard, Jean Damien, Constantin, Jean Michel, Perbet, Sebastien, Delmas, Julie, Pascal, Julien, Cayot, Sophie, Guerin, Renaud, Jabaudon, Matthieu, Roszyk, Laurence, Rolhion, Christine, Bourdier, Justine, Lematte, Mathilde, Gouhier, Charlène, Verlhac, Camille, Godet, Thomas, Radji, Sophiano, Caumon, Elodie, Thibault, Sandrine, Marx, Nikolaus, Schuerholz, Tobias, Pezechk, Jessica, Feld, Florian, Brülls, Christian, Beeker, Thorben, Simon, Tim Philipp, Deisz, Robert, Schindler, Achim, Meier, Bianca, Janisch, Thorsten, Hohn, Andreas, Schedler, Dirk, Wetsch, Wolfgang, Schröder, Daniel, Meier-Hellmann, Andreas, Lucht, Alexander, Henker, Robert, Römmer, Magdalena, Meinig, Torsten, Zacharowski, Kai D., Meybohm, Patrick, Lindau, Simone, Mutlak, Haitham, Kluge, Stefan, Ringeis, Grit, Füllekrug, Birgit, Singer, Brigitte, Nierhaus, Axel, Bangert, Katrin, De Heer, Geraldine, Frings, Daniel, Fuhrmann, Valentin, Müller, Jakob, Schreiber, Jörg, Sensen, Barbara, Siedler, Stephanie, Siewecke, Annekatrin, Söffker, Gerold, Wichmann, Dominic, Kerinn, Mélanie, Jaschinski, Ulrich, Kreuser, Ilse, Zanquila, Marlene, Kortgen, Andreas, Bloos, Frank, Gonnert, Falk, Thomas-Rüddel, Daniel, Haucke, Anja, Kolanos, Steffi, Kohlberg, Karina Knuhr, Bloos, Petra, Schwope, Katrin, Di Somma, Salvatore, Rossella, Marino, Russo, Veronica, Simona, Santarelli, Bartoli, Christopher, Navarin, Sylvia, Bongiovanni, Cristina, Orru, Michela, Quatrocchi, Daniela, Zoccoli, Giada, Varchetta, Antonella, Antonelli, Massimo, De Pascale, Gennaro, Vallecoccia, Maria Sole, Cutuli, Salvatore Lucio, Digravio, Valentina, Quattrochi, Daniela, D'Arrigo, Sonia, Leone, Filippo Elvino, Beishuizen, Bert, Rinket, Martin, Border, Natalie, Bos-Burgmeijer, Mariska, Braad, Astrid, Papendorp, S., Vermeijden, J., Pickkers, Peter, Van De A, Marieke, Van Wezel, Helen, Heunks, Leo, Bordar, Natalie, Luijten-Arts, Chantal, Hoedemaekers, Astrid, Van Der Hoeven, Hans, Roovers, Noortje, Hemelaar, Pleun, Intensive care medicine, ACS - Pulmonary hypertension & thrombosis, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, and UCL - (SLuc) Service de soins intensifs

Subjects
Male, medicine.medical_specialty, Multiple Organ Failure, MEDLINE, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Critical Care and Intensive Care Medicine, Sepsis, 03 medical and health sciences, Adrenomedullin, 0302 clinical medicine, Belgium, Germany, medicine, Research Letter, Humans, Lactic Acid, Hospital Mortality, Prospective Studies, Prospective cohort study, Aged, Netherlands, Proportional Hazards Models, Chi-Square Distribution, business.industry, lcsh:Medical emergencies. Critical care. Intensive care. First aid, 030208 emergency & critical care medicine, lcsh:RC86-88.9, Length of Stay, Middle Aged, medicine.disease, Prognosis, Shock, Septic, Survival Analysis, 3. Good health, Hospitalization, Patient Outcome Assessment, Intensive Care Units, 030228 respiratory system, Italy, Shock (circulatory), Emergency medicine, Female, France, medicine.symptom, business, Biomarkers
Abstract

Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial.AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock.Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5-148.1 pg/ml]. Initial SOFA score was 7 [IQR 5-10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9-2.9]; adjusted HR 1.6 [CI 1.1-2.5]) and between bio-ADM levels and SOFA score (p0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM70 pg/ml upon admission than in those with bio-ADM ≤ 70 pg/ml. In patients with bio-ADM70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5-9.8).AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial.ClinicalTrials.gov, NCT02393781 . Registered on March 19, 2015.

Published
2020

96. Early Changes Over Time in the Radiographic Assessment of Lung Edema Score Are Associated With Survival in ARDS

Author

Jabaudon, Matthieu, primary, Audard, Jules, additional, Pereira, Bruno, additional, Jaber, Samir, additional, Lefrant, Jean-Yves, additional, Blondonnet, Raiko, additional, Godet, Thomas, additional, Futier, Emmanuel, additional, Lambert, Céline, additional, Bazin, Jean-Etienne, additional, Bastarache, Julie A., additional, Constantin, Jean-Michel, additional, Ware, Lorraine B., additional, Souweine, Bertrand, additional, Eisenmann, Nathanael, additional, Quenot, Jean-Pierre, additional, Seguin, Philippe, additional, Asehnoune, Karim, additional, Lasocki, Sigismond, additional, Ferrandiere, Martine, additional, Sossou, Achile, additional, Langeron, Olivier, additional, Leone, Marc, additional, Dupont, Herve, additional, Veber, Benoit, additional, Ichai, Carole, additional, Rimmelé, Thomas, additional, Legay, François, additional, Grelon, Fabien, additional, Dahyot-Fizelier, Claire, additional, Cayot, Sophie, additional, Guerin, Renaud, additional, Verlhac, Camille, additional, Chabanne, Russell, additional, Cosserant, Bernard, additional, Lautrette, Alexandre, additional, Muller, Laurent, additional, Massanet, Pablo, additional, Boutin, Caroline, additional, Barbar, Saber, additional, Roger, Claire, additional, Belafia, Fouad, additional, Cisse, Moussa, additional, Monnin, Marion, additional, Conseil, Matthieu, additional, Carr, Julie, additional, De Jong, Audrey, additional, Chanques, Gérald, additional, Dargent, Auguste, additional, Crozon, Thomas, additional, Clauzel, Julien, additional, Le Core, Marinne, additional, Andreu, Pascal, additional, Lebouvrier, Thomas, additional, Launey, Yoann, additional, Roquilly, Antoine, additional, Cinotti, Raphael, additional, Tellier, Anne-Charlotte, additional, Barbaz, Mathilde, additional, Cohen, Benjamin, additional, Lemarche, Edouard, additional, Bertrand, Pierre-Marie, additional, Arbelot, Charlotte, additional, Zieleskiewicz, Laurent, additional, Hammad, Emmanuelle, additional, Duclos, Garry, additional, Calypso, Mathieu, additional, Orban, Jean-Christophe, additional, Quintard, Hervé, additional, Assefi, Mona, additional, Morel, Jerome, additional, Molliex, Serge, additional, Petitas, Frank, additional, and Nanadougmar, Hadanou, additional

Published
2020
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97. Assessment of a Novel Method for Non-invasive Sampling of the Distal Airspace in Acute Respiratory Distress Syndrome Patients Receiving Inhaled Sedation with Sevoflurane: the ANAISS Study Protocol

Author

Tronche, Pierre-Antoine, primary, Lalande, Robin, additional, Blondonnet, Raiko, additional, Roszyk, Laurence, additional, Zhai, Ruoyang, additional, Morand, Dominique, additional, Pereira, Bruno, additional, Sapin, Vincent, additional, Malinovsky, Jean-Marc, additional, Mourvillier, Bruno, additional, Constantin, Jean-Michel, additional, Cousson, Joël, additional, and Jabaudon, Matthieu, additional

Published
2020
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98. Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Author

Blondonnet, Raiko, primary, Paquette, Bertille, primary, Audard, Jules, primary, Guler, Ridvan, primary, Roman, François-Xavier, primary, Zhai, Ruoyang, primary, Belville, Corinne, primary, Blanchon, Loïc, primary, Godet, Thomas, primary, Futier, Emmanuel, primary, Bazin, Jean-Etienne, primary, Constantin, Jean-Michel, primary, Sapin, Vincent, primary, and Jabaudon, Matthieu, primary

Published
2020
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100. The receptor for advanced glycation end-products enhances lung epithelial wound repair: An in vitro study

Author

Zhai, Ruoyang, primary, Blondonnet, Raiko, additional, Ebrahimi, Ebrahim, additional, Belville, Corinne, additional, Audard, Jules, additional, Gross, Christelle, additional, Choltus, Helena, additional, Henrioux, Fanny, additional, Constantin, Jean-Michel, additional, Pereira, Bruno, additional, Blanchon, Loic, additional, Sapin, Vincent, additional, and Jabaudon, Matthieu, additional

Published
2020
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