593 results on '"J. Lotz"'
Search Results
52. Hauptindikationen für die kardiale MRT/CT bei Kindern und wie mache ich's?
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J Lotz
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Radiology, Nuclear Medicine and imaging - Published
- 2016
53. Atrioventricular Mechanics and Heart Failure in Ebstein's Anomaly—A Cardiovascular Magnetic Resonance Imaging Study
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A. Schuster, M. Broder, Johannes T. Kowallick, Michael Steinmetz, Gerd Hasenfuß, P. Llamata, Shelby Kutty, J. Lotz, Wieland Staab, Christina Unterberg-Buchwald, Matthias Seehase, and Thomas Paul
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,medicine.disease ,Heart failure ,Ebstein's anomaly ,Internal medicine ,Cardiology ,Medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Published
- 2016
54. Echokardiographische Quantifizierung der Pulmonalklappeninsuffizienz bei angeborenen Herzfehlern im Vergleich zur kardialen Magnetresonanztomographie
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J. Lotz, V. Gravenhorst, Thomas Paul, Michael Steinmetz, L. Kammerer, and C. Dellas
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Pulmonary and Respiratory Medicine ,Gynecology ,medicine.medical_specialty ,business.industry ,medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Published
- 2016
55. Competing Flow between Partial Circulatory Support and Native Cardiac Output: a computational Fluid Dynamics-Study
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C. Karmonik, Andre R. Simon, Fabian Rengier, Philip Raake, Alexander Weymann, Aron-Frederik Popov, Matthias Karck, J. Lotz, Arjang Ruhparwar, Andreas O. Doesch, S. Partovi, and Jennifer Engelke
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Pulmonary and Respiratory Medicine ,Transplantation ,medicine.medical_specialty ,Cardiac output ,business.industry ,Computational fluid dynamics ,Flow (mathematics) ,Internal medicine ,Circulatory system ,Cardiology ,Medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Intensive care medicine - Published
- 2016
56. Konsensusempfehlungen der DRG/DGK/DGPK zum Einsatz der Herzbildgebung mit Computertomographie und Magnetresonanztomographie
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S. Achenbach, J. Barkhausen, M. Beer, P. Beerbaum, T. Dill, J. Eichhorn, S. Fratz, M. Gutberlet, M. Hoffmann, A. Huber, P. Hunold, C. Klein, G. Krombach, K.-F. Kreitner, T. Kühne, J. Lotz, D. Maintz, H. Marholdt, N. Merkle, D. Messroghli, S. Miller, I. Paetsch, P. Radke, H. Steen, H. Thiele, S. Sarikouch, and R. Fischbach
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Cardiology and Cardiovascular Medicine - Published
- 2012
57. Transparency ratio in γA→η′A′ and the in-medium η′ width
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B. Krusche, I. Horn, V. Metag, A. Radkov, S. Lugert, O. Bartholomy, D. Menze, Angels Ramos, Eberhard Klempt, S. Höffgen, K.-T. Brinkmann, T. Szczepanek, Ch. Wendel, I. Jaegle, A. Süle, V. V. Sumachev, J. Junkersfeld, K. Essig, C. Morales, M. Fuchs, H. Dutz, Frank Klein, Yu. A. Beloglazov, A. Ehmanns, E. Gutz, Ch. Funke, M. Konrad, Lalit Mohan Pant, M. Ostrick, H. Kalinowsky, M. Pfeiffer, Friedrich Klein, K. Makonyi, R. Ewald, I. V. Lopatin, T. Mertens, Herbert Löhner, H. van Pee, V. Crede, B. Kopf, D. Trnka, J. Langheinrich, J. G. Messchendorp, D. Elsner, U. Thoma, Ankhi Roy, R. W. Novotny, J. Lotz, D. Walther, Ph. Hoffmeister, B. Schoch, Ch. Schmidt, Eulogi Oset, H. Schmieden, D. E. Bayadilov, A. B. Gridnev, Mariana Nanova, I. Fabry, S. Schadmand, R. Gregor, and R. Varma
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Physics ,Nuclear and High Energy Physics ,Photon ,Proton ,Meson ,010308 nuclear & particles physics ,Scattering ,Nuclear Theory ,Niobium ,chemistry.chemical_element ,Rest frame ,7. Clean energy ,01 natural sciences ,Momentum ,Nuclear physics ,Cross section (physics) ,chemistry ,0103 physical sciences ,High Energy Physics::Experiment ,Atomic physics ,Nuclear Experiment ,010306 general physics - Abstract
The photoproduction of η ′ -mesons off different nuclei has been measured with the CBELSA/TAPS detector system for incident photon energies between 1500–2200 MeV. The transparency ratio has been deduced and compared to theoretical calculations describing the propagation of η ′ -mesons in nuclei. The comparison indicates a width of the η ′ -meson of the order of Γ = 15 – 25 MeV at ρ = ρ 0 for an average momentum p η ′ = 1050 MeV / c , at which the η ′ -meson is produced in the nuclear rest frame. The inelastic η ′ N cross section is estimated to be 3–10 mb. Parameterizing the photoproduction cross section of η ′ -mesons by σ ( A ) = σ 0 A α , a value of α = 0.84 ± 0.03 has been deduced.
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- 2012
58. Joule-class 940 nm diode laser bars for millisecond pulse applications
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C. Frevert, J. Neukum, Alina Pranovich, Tomas Mocek, Paul Crump, J. Lotz, W. Fassbender, M. Divoky, Günther Tränkle, Arnim Ginolas, S. Knigge, M. De Vido, Antonio Lucianetti, T. Topfer, A. Maassdorf, G. Erbert, Jörg Körner, and Klaus Ertel
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Brightness ,Millisecond ,Materials science ,business.industry ,Joule ,Laser ,Power (physics) ,law.invention ,Pulse (physics) ,Resonator ,Optics ,law ,Optoelectronics ,business ,Diode - Abstract
Diode laser bars with optimized epitaxial designs, long resonators and passivated facets deliver joule-class millisecond pulses (kilowatts of peak power) with the properties needed by advanced high-energy-class solid-state laser systems, at brightness over 3 MW/(cm2sr).
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- 2015
59. Diagnostik der koronaren Herzkrankheit –aktueller Stand der MRT
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J. Lotz
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Coronary artery disease ,medicine.medical_specialty ,business.industry ,Internal medicine ,Cardiology ,Medicine ,Myocardial infarction ,business ,medicine.disease - Published
- 2010
60. Growth hormone substitution in growth hormone-deficient adults: Effects on collagen type I synthesis and skin thickness
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J. Beyer, Peter H. Kann, B. Piepkorn, Winfried Prellwitz, J. Lotz, and Schehler B
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Cutis ,Stimulation ,Matrix (biology) ,Placebo ,Endocrinology ,Double-Blind Method ,Forearm ,Internal medicine ,Dry skin ,Internal Medicine ,Humans ,Medicine ,Prospective Studies ,Growth Disorders ,Skin ,Ultrasonography ,Chemotherapy ,Human Growth Hormone ,business.industry ,General Medicine ,Middle Aged ,Peptide Fragments ,Recombinant Proteins ,Procollagen peptidase ,medicine.anatomical_structure ,Female ,Collagen ,medicine.symptom ,business ,Procollagen - Abstract
Growth hormone stimulates collagen type I synthesis. Collagen type I is a common matrix compound in a large number of connective tissues. The aim of our study was to prove whether a stimulation of collagen type I synthesis might be accompanied by a deposition of collagen type I in the skin (cutis). Twenty growth hormone-deficient hypopituitary patients were included in a randomised, double-blind, placebo controlled, prospective, twelve-month study (eighteen patients assessable at the end of the study). The patients were treated with recombinant human growth hormone 0.25 U/kg/week subdivided in daily subcutaneous injections beginning with half the dosage during the first four weeks. During the first six months half of the patients were treated with placebo. PICP, the indicator of collagen type I synthesis, was increased after six months of therapy when compared to placebo. Skin thickness measured by ultrasound at the forearm and mechanically at the dorsum of the hand with strong compression of the skin both increased significantly following growth hormone substitution. Our data indicate that the stimulation of collagen type I synthesis by growth hormone substitution is followed by a deposition of collagen type I in the skin.
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- 2009
61. Detailed kinetic study of cumene isopropylation in a liquid–liquid biphasic system using acidic chloroaluminate ionic liquids
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Peter S. Schulz, Peter Wasserscheid, D. Schmitt, Joni Joni, and T. J. Lotz
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Cumene ,Inorganic chemistry ,Catalysis ,Propene ,Chemical kinetics ,chemistry.chemical_compound ,COSMO-RS ,chemistry ,Phase (matter) ,Ionic liquid ,Organic chemistry ,Physical and Theoretical Chemistry ,Solubility - Abstract
A kinetic study of cumene isopropylation has been carried out using the acidic ionic liquid 1-ethyl-3-methylimidazolium chloride ([EMIM]Cl)/AlCl3 (molar ratio 1:2) as the catalyst phase in a semi-batch liquid–liquid biphasic reaction system. Kinetic models representing the alkylation reaction network have been established based on reaction temperature and propylene partial pressure variations. By comparing the results of the kinetic models with the measured concentrations in the liquid organic phase, the importance of the different product solubilities in the acidic ionic liquid became evident. Correction of the product concentrations in the organic phase based on a COSMO-RS calculation of the relative product solubilities in the acidic ionic liquid [EMIM][Al2Cl7] gave a remarkably good prediction of the reaction kinetics by the kinetic model. These findings demonstrate the suitability of COSMO-RS to predict the relative solubilities of different aromatic compounds in highly reactive catalytic systems.
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- 2008
62. Klinik und Diagnose der Tuberkulose
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A. Strassburg, U. Greinert, Barbara Kalsdorf, J. Lotz, and Christoph Lange
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Tuberculosis ,medicine.diagnostic_test ,business.industry ,MEDLINE ,Physical examination ,medicine.disease ,Active tuberculosis ,Surgery ,Tuberculosis diagnosis ,Radiological weapon ,medicine ,Medical history ,Mycobacterium tuberculosis culture ,business ,Intensive care medicine - Abstract
Recently, major advances have been accomplished in the diagnosis of active tuberculosis. A comprehensive diagnostic approach for a patient with possible tuberculosis includes a detailed medical history and clinical examination as well as the results of radiological, microbiological, immunological, molecular-biological and histological methods. In concert, these results enable the clinician to rapidly develop a decision with a high probability for the diagnosis or exclusion of active tuberculosis. Therapeutic intervention can thus be made early, even though corrections in these decisions need to be considered depending on the results of Mycobacterium tuberculosis culture and sensitivity testing.
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- 2008
63. N∗ and Δ∗ decays into Nπ0π0
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D. Menze, Yu. A. Beloglazov, A. V. Sarantsev, Eberhard Klempt, H. Kalinowsky, I. Fabry, V. V. Sumachev, T. Szczepanek, D. Walther, V. A. Nikonov, M. Fuchs, S. Hoeffgen, O. Bartholomy, A. Foesel, A. V. Anisovich, I. Horn, V. Crede, J. Lotz, J. Langheinrich, M. Konrad, H. Flemming, H. van Pee, C. Funke, H. Koch, R. W. Gothe, M. Ostrick, B. Kopf, H. Matthaey, Gisela Anton, U. Thoma, D. V. Novinski, R. Bantes, J. Ernst, Ch. Schmidt, J. Junkersfeld, H. Loehner, B. Krusche, B. Schoch, I. V. Lopatin, H. Schmieden, R. Beck, J. Hoessl, A. B. Gridnev, G. Suft, C.-H. Weinheimer, E. Gutz, A. Ehmanns, and Frank Klein
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Baryon ,Physics ,Nuclear and High Energy Physics ,Pion ,Proton ,Hadron spectroscopy ,Partial wave analysis ,Quark model ,Pi ,Resonance ,High Energy Physics::Experiment ,Atomic physics - Abstract
Decays of baryon resonances in the second and the third resonance region into N pi(0)pi(0) are studied by photoproduction of two neutral pions off protons. Partial decay widths of N* and Delta* resonances decaying into Delta(1232)pi, N(pi pi)(S), N(1440)P-11 pi, and N(1520)D-13 pi are determined in a partial wave analysis of this data and of data from other reactions. Several partial decay widths were not known before. Interesting decay patterns are observed which are not even qualitatively reproduced by quark model calculations. In the second resonance region, decays into Delta(1232)pi dominate clearly. The N(pi pi)(S)-wave provides a significant contribution to the cross section, especially in the third resonance region. The P-13(1720) properties found here are at clear variance to PDG values. (c) 2007 Elsevier B.V. All rights reserved.
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- 2008
64. Bildgebende Diagnostik von Lebertumoren
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Michael Galanski, B. Boozari, Michael Gebel, and J. Lotz
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medicine.medical_specialty ,Liver tumor ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Liver tumours ,medicine.disease ,Benign tumor ,Liver lesion ,Needle biopsy ,Internal Medicine ,medicine ,Medical imaging ,Radiology ,business ,Contrast-enhanced ultrasound - Abstract
Nowadays, contrast enhanced ultrasound (CEUS) is an imaging technique equivalent to multidetector computed tomography (MDCT) and magnetic resonance imaging (MRI) for the detection and characterization of focal liver lesions. These methods have comparable sensitivity and specificity in differentiating a liver lesion as "benign" or "malignant". For benign lesions, CEUS is the recommended method of the choice. In unclear cases, or if CEUS is not available, MRI or CT are the methods of the second choice. If a benign tumor remains unclear, then a needle biopsy is recommended. In the case of a malignant tumor, it is necessary to use a second imaging technique besides CEUS. In addition to the detection and characterization of a liver tumor, CT and MRI provide information on the extrahepatic spread of a tumor, particularly into the lung or retroperitoneum. The rapid development of surgical and interventional approaches requires accurate information on the character and number of malignant liver lesions. Therefore, the combined use of CEUS and MDCT or MRI currently represents the most modern and optimal standard of imaging. The standardization of CT and MRI protocols has increased the general diagnostic level of these images. Adequate training and a certificate for the use of CEUS is recommended in order to maintain the high diagnostic level of this method (EFSUMB guide lines). An optimal interdisciplinary imaging strategy for focal liver lesions minimises unnecessary invasive or potentially harmful imaging and reduces health costs.
- Published
- 2007
65. Pelvic lymph node dissection for nodal oligometastatic prostate cancer detected by 68Ga-PSMA-positron emission tomography/computerized tomography
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S, Hijazi, B, Meller, C, Leitsmann, A, Strauss, J, Meller, C O, Ritter, J, Lotz, H-U, Schildhaus, L, Trojan, and C O, Sahlmann
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Male ,Prostatectomy ,Predictive Value of Tests ,Lymphatic Metastasis ,Positron-Emission Tomography ,Humans ,Lymph Node Excision ,Prostatic Neoplasms ,Middle Aged ,Multimodal Imaging ,Sensitivity and Specificity ,Aged ,Retrospective Studies - Abstract
The first evaluation of pelvic extended lymph node dissection (pLND) in oligometastatic prostate cancer (PCa) detected by (68)Ga-PSMA PET/CT.Retrospective analysis of 35 PCa patients underwent (68)Ga-PSMA PET/CT affected by biochemical recurrence (BCR) after curative treatment (n = 23) or before primary therapy of high-risk PCa (n = 12). We performed pLND associated with pathologic imaging in 17 men with nodal oligometastatic PCa.Indicative lesions for PCa in PET/CT were detected in 91.4% (32 of 35) of patients. Nodal, bone, visceral (pulmonary), and within the prostate suspected disease were detected in 72% (23 of 32), 16% (5 of 32), 6% (2 of 32), and 47% (15 of 32) of patients, respectively. Median serum PSA in patients with pathological radiotracer uptake in recurrent and high-risk PCa patients was 2.9 ng/ml (range 0.18-30) and 19.5 ng/ml (range 6-90), respectively. The median number of removed lymph nodes with pLND in recurrent and high-risk PCa was 10 (range 4-17) and 12 (range 8-29) per patient and the median number of positive lymph nodes was 1 (range 1-2) and 3 (2-3) per patient, respectively. In total, two false positive and one false-negative lymph node were found. Diagnostic accuracies per nodal lesion in total of 213 removed nodes: sensitivity, 94%; specificity, 99%; positive predictive value (PPV), 89%, and negative predictive value (NPV), 99.5%. After pLND, 53% (9 of 17) of patients received androgen deprivation therapy and/or radiation therapy and hormonal therapy, while 47% (8 of 17) of patients remained free of any post-surgery therapy. Follow-up PSA remained less than 0.2 ng/ml in 82% (14 of 17) of patients. After pLND, immediate BCR (PSA never measured less than 0.2 ng/ml) in 18% (3 of 17) of patients was recorded.This represents the first study of pLND in the setting of nodal oligometastatic PCa detected by (68)Ga-PSMA PET/CT. The use of (68)Ga-PSMA PET/CT could be to improve the accuracy for the detection of nodal micrometastases. These promising findings need validation in larger studies.
- Published
- 2015
66. Erratum: Modification of theω-Meson Lifetime in Nuclear Matter [Phys. Rev. Lett.100, 192302 (2008)]
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M. Kotulla, A. Ehmanns, I. Jaegle, Ulrich Mosel, Gisela Anton, V. Metag, V. Crede, S. Hoeffgen, I. Fabry, R. W. Gothe, Yu. A. Beloglazov, T. Mertens, J. C. S. Bacelar, M. Konrad, S. Shende, J. G. Messchendorp, D. E. Bayadilov, E. Gutz, H. Dutz, J. Lotz, A. B. Gridnev, Mariana Nanova, J. Hoessl, O. Bartholomy, Michael Fuchs, D. Trnka, J. Langheinrich, R. Gregor, I. V. Lopatin, D. Elsner, R. W. Novotny, Ph. Hoffmeister, R. Castelijns, R. Ewald, K. Essig, S. Schadmand, S. Lugert, Eberhard Klempt, P. Muehlich, J. Junkersfeld, H. Loehner, Fritz Klein, I. Horn, D. Menze, B. Kopf, Ch. Funke, B. Krusche, H. Kalinowsky, R. Bogendoerfer, and Frank Klein
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Nuclear physics ,Physics ,Particle physics ,Meson production ,Meson ,General Physics and Astronomy ,Nuclear matter ,Omega - Published
- 2015
67. Cardiovascular magnetic resonance feature-tracking assessment of myocardial mechanics: Intervendor agreement and considerations regarding reproducibility
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A, Schuster, V-C, Stahnke, C, Unterberg-Buchwald, J T, Kowallick, P, Lamata, M, Steinmetz, S, Kutty, M, Fasshauer, W, Staab, J M, Sohns, B, Bigalke, C, Ritter, G, Hasenfuß, P, Beerbaum, and J, Lotz
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Adult ,Male ,Cardiotonic Agents ,Dobutamine ,Image Interpretation, Computer-Assisted ,Humans ,Magnetic Resonance Imaging, Cine ,Reproducibility of Results ,Female ,Middle Aged ,Healthy Volunteers ,Software ,Article - Abstract
Aim To assess intervendor agreement of cardiovascular magnetic resonance feature tracking (CMR-FT) and to study the impact of repeated measures on reproducibility. Materials and methods Ten healthy volunteers underwent cine imaging in short-axis orientation at rest and with dobutamine stimulation (10 and 20 μg/kg/min). All images were analysed three times using two types of software (TomTec, Unterschleissheim, Germany and Circle, cvi42, Calgary, Canada) to assess global left ventricular circumferential (Ecc) and radial (Err) strains and torsion. Differences in intra- and interobserver variability within and between software types were assessed based on single and averaged measurements (two and three repetitions with subsequent averaging of results, respectively) as determined by Bland–Altman analysis, intraclass correlation coefficients (ICC), and coefficient of variation (CoV). Results Myocardial strains and torsion significantly increased on dobutamine stimulation with both types of software (p, Highlights • This is the first comparison of two types of CMR-FT software resulting in clinically valuable inter-vendor agreement data. • Assessment of myocardial strain and torsion is feasible with both types of software at rest and with dobutamine stimulation. • For both vendors, Ecc qualifies as the most robust parameter with the lowest variability.
- Published
- 2015
68. Progress in high-energy-class diode laser pump sources
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Frank Bugge, J. Sebastian, W. Fassbender, G. Erbert, S. Knigge, Joachim Hein, J. Lotz, C. Frevert, J. Neukum, Paul Crump, Martin Zorn, Joerg Körner, R. Hüslewede, T. Topfer, A. Pietrzak, and Günther Tränkle
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Materials science ,business.industry ,Bar (music) ,Joule ,Laser pumping ,Laser ,law.invention ,Semiconductor laser theory ,Optics ,law ,Solid-state laser ,Spectral width ,Optoelectronics ,business ,Diode - Abstract
A new generation of diode-pumped high-energy-class solid-state laser facilities is in development that generate multijoule pulse energies at around 10 Hz. Currently deployed quasi-continuous-wave (QCW) diode lasers deliver average inpulse pump powers of around 300 W per bar. Increased power-per-bar helps to reduce the system size, complexity and cost per Joule and the increased pump brilliance also enables more efficient operation of the solid state laser itself. It has been shown in recent studies, that optimized QCW diode laser bars centered at 940…980 nm can operate with an average in-pulse power of > 1000 W per bar, triple that of commercial sources. When operated at pulsed condition of 1 ms, 10 Hz, this corresponds to > 1 J/bar. We review here the status of these high-energy-class pump sources, showing how the highest powers are enabled by using long resonators (4…6 mm) for improved cooling and robustly passivated output facets for high reliability. Results are presented for prototype passively-cooled single bar assemblies and monolithic stacked QCW arrays. We confirm that 1 J/bar is sustained for fast-axis collimated stacks with a bar pitch of 1.7 mm, with narrow lateral far field angle (< 12° with 95% power) and spectral width (< 12 nm with 95% power). Such stacks are anticipated to enable Joule/bar pump densities to be used near-term in commercial high power diode laser systems. Finally, we briefly summarize the latest status of research into bars with higher efficiencies, including studies into operation at sub-zero temperatures (-70°C), which also enables higher powers and narrower far field and spectra.
- Published
- 2015
69. Clinically Applicable 7-Tesla Magnetic Resonance Visualization of Transplanted Human Adult Stem Cells Labeled with CliniMACS® Nanoparticles
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F Wolf, A Ghodsizad, T. Voelkel, M. Klein, J Lotz, Christoph Bara, Ulrich Martin, Axel Haverich, M Niehaus, Emmeran Gams, M Makoui, and Arjang Ruhparwar
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Male ,Pulmonary and Respiratory Medicine ,Pathology ,medicine.medical_specialty ,Swine ,Myocardial Infarction ,Metal Nanoparticles ,Neovascularization ,medicine ,Animals ,Humans ,Tissue Distribution ,Myocardial infarction ,Bone Marrow Transplantation ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,medicine.disease ,Immunohistochemistry ,Magnetic Resonance Imaging ,Transplantation ,Adult Stem Cells ,medicine.anatomical_structure ,Heart failure ,cardiovascular system ,Iron-Dextran Complex ,Surgery ,Bone marrow ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Adult stem cell - Abstract
Background Intra-myocardial transplantation of bone marrow derived cells is currently under clinical evaluation as a therapy for heart failure. A major limitation of all clinical studies for myocardial restoration through cell transfer is the inability to track the fate of the transplanted cells. We present a clinically applicable technique using advanced ultra high-field 7-Tesla (7T) magnetic resonance imaging (MRI) of nanoparticle-labeled transplanted human EPCs in porcine ischemic hearts. Methods CD133 positive cells were isolated from bone marrow by magnetic bead selection. Positive cells (5 - 8 x 10 (6) cells) were transplanted into porcine ischemic myocardium (n = 8). Control animals (n = 3) received a medium injection. MRI on a 7T scanner was performed to demonstrate the distribution of the EPCs. Results CD133+ cells were identified on gradient echo images (T(1)-weighted) within the myocardium 4 weeks after transplantation. Conclusions Magnetically labeled EPCs transplanted for therapeutic neovascularization or reduction of infarct size in myocardial ischemia can be visualized by MRI at high-field strengths.
- Published
- 2006
70. A blue kidney chronic renal failure as a consequence of siderosis in paroxysmal nocturnal hemoglobinuria?
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Philipp Kümpers, A Herrmann, Michael Mengel, J Lotz, and Anke Schwarz
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Male ,Radiography, Abdominal ,Nephrology ,medicine.medical_specialty ,Pathology ,Siderosis ,Hemoglobinuria, Paroxysmal ,Kidney ,urologic and male genital diseases ,Gastroenterology ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Humans ,Acute tubular necrosis ,Aged ,medicine.diagnostic_test ,business.industry ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Creatinine ,Paroxysmal nocturnal hemoglobinuria ,Kidney Failure, Chronic ,Hemoglobinuria ,Renal biopsy ,business ,Glomerular Filtration Rate ,Kidney disease - Abstract
Acute renal failure is a known complication during hemolytic crisis in paroxysmal nocturnal hemoglobinuria (PNH). However, chronic renal failure is rare despite the well-known spectacular hemosiderosis of the kidneys due to chronic hemolysis. Here, we report about a 74-year-old man with PNH who developed acute on chronic renal failure after an episode of intercurrent urinary tract infection and subsequent hemolytic crisis. Mild chronic hemolysis, well-documented over the past decade, had long been considered the cause of a constantly declining glomerular filtration rate. Accordingly, magnetic resonance imaging during admission demonstrated marked siderosis of both kidneys, supporting the hypothesis that chronic renal failure (CRF) was likewise related to PNH. However, a renal biopsy revealed acute tubular necrosis and distinct renal siderosis, as expected. Additionally, tubulointerstitial injury and global glomerular sclerosis, best classified as arterionephrosclerosis, were present. In retrospect, these findings were explained by a 15-year history of hypertension and a 4-year medication with cyclosporine. Careful diagnostic workup including a renal biopsy is mandatory, given a misleadingly suggestive correlation between chronic hemolysis and CRF. Chronic renal failure in PNH is a diagnosis of exclusion, even if radiologic evidence of heavy siderosis draws off the physician's attention.
- Published
- 2006
71. Performance Evaluation of the ADVIA 2120 Hematology Analyzer: An International Multicenter Clinical Trial
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Neil S. Harris, Gianluigi Devoto, Suzanne R. Fletcher, Alexander Kratz, J. Lotz, David Wranovics, Josep M Jou, James Pappas, and Mary Wilkinson
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business.industry ,Biochemistry (medical) ,Clinical Biochemistry ,Blood count ,Clinical performance ,Hematology ,Sensitivity and Specificity ,Biological fluid ,Blood Cell Count ,Clinical trial ,Automation ,Leukocyte Count ,Hematology analyzer ,Reticulocyte Count ,Humans ,Medicine ,New device ,In patient ,Lymphocyte Count ,Hemoglobin measurement ,business ,Software ,Biomedical engineering - Abstract
Automated cell counters are widely used in modern clinical laboratories to provide reliable, fast, and cost-effective complete blood counts (CBCs), white blood cell differentials, and reticulocyte measurements. In addition, some advanced instruments provide novel parameters, such as the hemoglobin content of reticulocytes or the percentage of hypochromic cells, and are capable of analysis of a variety of body fluids. Bayer recently introduced the ADVIA 2120 system as an automation-ready cell counter for mid- to high-volume testing in the clinical laboratory. This instrument, which builds on the established technology of the ADVIA 120 system, operates with a cyanide-free method for hemoglobin measurement, has a new user interface, and can routinely analyze biological fluid samples in addition to blood. We used 749 samples from 6 worldwide trial sites to evaluate the clinical performance of this new device. Accuracy of the ADVIA 2120 system versus its predecessor model, the ADVIA 120 system, was excellent for all CBC and white cell differential parameters and reticulocyte counts (all correlation coefficients except for basophils >0.9). Correlation of the white cell differential with the standard manual method and within-run precision of the ADVIA 2120 system also was very good. Use of the novel cyanide-free method for hemoglobin measurement had no clinically significant impact on hemoglobin results, even in patients with hemoglobinopathies. We concluded that the ADVIA 2120 system has clinically equivalent performance to the ADVIA 120 system.
- Published
- 2005
72. Standardised work-up programme for fever of unknown origin and contribution of magnetic resonance imaging for the diagnosis of hidden systemic vasculitis
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E Raum, M C Jendro, Andresen J, Henning Zeidler, Annette D. Wagner, J Lotz, and J G Kuipers
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musculoskeletal diseases ,Adult ,Male ,medicine.medical_specialty ,Pediatrics ,Immunology ,Aorta, Thoracic ,Fever of Unknown Origin ,General Biochemistry, Genetics and Molecular Biology ,Clinical Protocols ,Rheumatology ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Arteritis ,Fever of unknown origin ,skin and connective tissue diseases ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Takayasu Arteritis ,Work-up ,Extended Report ,Female ,Radiology ,Vasculitis ,business ,Systemic vasculitis - Abstract
Background: Fever of unknown origin (FUO) is a diagnostic challenge. Rheumatologists are often in charge of patients with FUO because the vasculitides, especially, are potential and common causes of FUO. Objective: To evaluate the value of a standardised investigation to identify the cause of FUO. Methods: A standardised work-up programme for patients with FUO was started at the beginning of September 1999. The rate of identified causes of FUO was compared between all patients with FUO admitted to a tertiary care centre of rheumatology between January 1996 and August 1999 (control group) and September 1999 and January 2003 (work-up group). In January 2002 magnetic resonance imaging (MRI) was added to the investigation. Results: 67 patients with FUO were identified—32 before and 35 after institution of the work-up programme. Before implementation 25% of all patients with FUO remained undiagnosed, after implementation 37%. After institution of the investigation the percentage of patients with vasculitides increased significantly from 6% (n = 2) to 26% (n = 9, p = 0.047, Fisher's exact test). This increase could be attributed to the addition of MRI in 2002. When all patients with FUO before 2002 (n = 55) and thereafter (n = 12) were compared the prevalence of systemic vasculitis increased from 11% (n = 6) to 42% (n = 5, p = 0.021). Conclusion: Implementation of a standardised work-up programme for FUO did not improve the overall rate of diagnosis. Addition of MRI significantly increased the diagnosis of systemic vasculitis as the underlying cause of FUO. MRI should be included in the investigation of patients with FUO when vasculitis is suspected.
- Published
- 2005
73. The use of differential display to isolate viral genomic sequence for rapid development of PCR-based detection methodsA test case using Taura syndrome virus
- Author
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Y LU, S WANG, and J LOTZ
- Subjects
Virology - Published
- 2004
74. The Total Right / Left - Volume - Index: A new and simplified CMR measure to evaluate the severity of Ebstein’s anomaly of the tricuspid valve
- Author
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C. Unterberg, P. Lauerer, J. Lotz, Shelby Kutty, Wieland Staab, Thomas Paul, A. Schuster, Johannes T. Kowallick, Michael Steinmetz, O. Hösch, M. Faßhauer, J. M. Sohns, and T. T. Nguyen
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Tricuspid valve ,Index (economics) ,business.industry ,Measure (physics) ,medicine.disease ,medicine.anatomical_structure ,Ebstein's anomaly ,Internal medicine ,Cardiology ,Medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Volume (compression) - Published
- 2014
75. Quantification of intra and inter-ventricular dyssynchrony in Ebstein’s anomaly by CMR myocardial feature tracking
- Author
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S.C. Alt, J. Lotz, Gerd Hasenfuß, C. Unterberg, J. M. Sohns, A. Schuster, Thomas Paul, Michael Steinmetz, and P.P. Lamata
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Pediatrics ,business.industry ,Myocardial feature ,medicine.disease ,Internal medicine ,Ebstein's anomaly ,medicine ,Cardiology ,Surgery ,Cardiology and Cardiovascular Medicine ,Ventricular dyssynchrony ,business - Published
- 2014
76. Systems engineering in the Large Synoptic Survey Telescope project: an application of model based systems engineering
- Author
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Paul J. Lotz, C. Claver, Francisco Delgado, Brian M. Selvy, G. P. Dubois-Felsmann, George Z. Angeli, P. Hascall, Jacques Sebag, S. L. Marshall, and German Schumacher
- Subjects
System requirements ,Requirements engineering ,Computer science ,Systems Modeling Language ,Process (engineering) ,Systems engineering ,Model-based systems engineering ,Systems architecture ,Use case ,Central element - Abstract
The Large Synoptic Survey Telescope project was an early adopter of SysML and Model Based Systems Engineering practices. The LSST project began using MBSE for requirements engineering beginning in 2006 shortly after the initial release of the first SysML standard. Out of this early work the LSST’s MBSE effort has grown to include system requirements, operational use cases, physical system definition, interfaces, and system states along with behavior sequences and activities. In this paper we describe our approach and methodology for cross-linking these system elements over the three classical systems engineering domains – requirement, functional and physical - into the LSST System Architecture model. We also show how this model is used as the central element to the overall project systems engineering effort. More recently we have begun to use the cross-linked modeled system architecture to develop and plan the system verification and test process. In presenting this work we also describe “lessons learned” from several missteps the project has had with MBSE. Lastly, we conclude by summarizing the overall status of the LSST’s System Architecture model and our plans for the future as the LSST heads toward construction.
- Published
- 2014
77. LSST Telescope and site status
- Author
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Oliver Wiecha, William Schoening, J. DeVries, Paul J. Lotz, William J. Gressler, John Andrew, Jacques Sebag, Edward Hileman, and Douglas R. Neill
- Subjects
Telescope ,Observatory ,Computer science ,law ,Systems engineering ,Active optics ,Telescope mount ,Large Synoptic Survey Telescope ,Design review ,Remote sensing ,law.invention - Abstract
The Large Synoptic Survey Telescope (LSST) has recently completed its Final Design Review and the Project is preparing for a 2014 construction authorization. The telescope system design supports the LSST mission to conduct a wide, fast, deep survey via a 3-mirror wide field of view optical design, a 3.2-Gpixel camera, and an automated data processing system. The observatory will be constructed in Chile on the summit of Cerro Pachon. This paper summarizes the status of the Telescope and Site group. This group is tasked with design, analysis, and construction of the summit and base facilities and infrastructure necessary to control the survey, capture the light, and calibrate the data. Several early procurements of major telescope subsystems have been completed and awarded to vendors, including the mirror systems, telescope mount assembly, hexapod and rotator systems, and the summit facility. These early contracts provide for the final design of interfaces based upon vendor specific approaches and will enable swift transition into construction. The status of these subsystems and future LSST plans during construction are presented.
- Published
- 2014
78. Die Seltenen: sonstige primäre Kardiomyopathien
- Author
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J Lotz
- Subjects
Radiology, Nuclear Medicine and imaging - Published
- 2014
79. Mobile Aufklärung
- Author
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A Seif, L Gasenzer, C Funke, and J Lotz
- Subjects
Radiology, Nuclear Medicine and imaging - Published
- 2014
80. European Multicenter Analytical Evaluation of the ARCHITECT STAT High Sensitive Troponin-I Immunoassay
- Author
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M Krintus, M Kozinski, P Boudry, N Estañ Capell, U Köller, K Lackner, G Lefèvre, L Lennartz, J Lotz, A Mora Herranz, M Nybo, M Plebani, M B Sandberg, W Schratzberger, J Shih, Ø Skadberg, A Taoufik Chargui, M Zaninotto, and G Sypniewska
- Published
- 2014
- Full Text
- View/download PDF
81. [Imaging technique and current status of valvular heart disease using cardiac MRI]
- Author
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J, Lotz and J M, Sohns
- Subjects
Heart Valve Diseases ,Humans ,Magnetic Resonance Imaging, Cine ,Image Enhancement ,Heart Valves - Abstract
The main indications for cardiac magnetic resonance imaging (MRI) in the evaluation of valvular heart disease are pathologies of the aortic and pulmonary valve. For mitral and tricuspid valve pathologies MRI is not the first line modality as these are usually well visualized by echocardiography. The advantages of MRI in valvular heart disease are a high reliability in the evaluation of ventricular volumes and function as well as the assessment of the perivalvular arterial or atrial structures. This reliability and the limitless access to any imaging plane partially compensates for the lower temporal and spatial resolution in comparison to echocardiography. In patients with congenital heart disease, cardiac MRI is established as a valuable diagnostic tool in daily clinical management, especially for the evaluation of pulmonary valve defects. Nevertheless, echocardiography remains the first-line diagnostic imaging tool for the foreseeable future.
- Published
- 2013
82. Measurement of the beam asymmetry Σ in πeta; production off the proton with the CBELSA/TAPS experiment⋆
- Author
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C. Morales, S. Schadmand, D. Novinsky, R. Beck, A. Ehmanns, M. Konrad, K. Essig, Frank Klein, A. Süle, T. Szczepanek, J. Junkersfeld, Lalit Mohan Pant, S.V. Shende, V. Sokhoyan, M. Fuchs, I. V. Lopatin, V. V. Sumachev, Yu. A. Beloglazov, M. Ostrick, H. Schmieden, Ch. Wendel, V. Metag, Friedrich Klein, D. E. Bayadilov, A. V. Sarantsev, A. B. Gridnev, M. Kotulla, R. Castelijns, I. Jägle, U. Thoma, M. Pfeiffer, Matthew Lang, O. Bartholomy, A. Radkov, R. Novotny, H. Dutz, V. Crede, M. Nanova, H. Kalinowsky, D. Menze, V. Kleber, K. Fornet-Ponse, R. Gregor, J. Langheinrich, J. C. S. Bacelar, S. Lugert, D. Walther, I. Fabry, A. V. Anisovich, Ch. Schmidt, J. Lotz, J. G. Messchendorp, D. Trnka, S. Kammer, R. Ewald, Ch. Funke, H. van Pee, I. Horn, Ch. Weinheimer, R. W. Gothe, T. Mertens, Herbert Löhner, B. Krusche, E. Gutz, B. Bantes, V. A. Nikonov, D. Elsner, Ph. Hoffmeister, Eberhard Klempt, B. Schoch, and S. Höffgen
- Subjects
Physics ,Nuclear and High Energy Physics ,Photon ,Proton ,media_common.quotation_subject ,Bremsstrahlung ,Particle accelerator ,Asymmetry ,Resonance (particle physics) ,law.invention ,Nuclear physics ,Pair production ,law ,Atomic physics ,Nuclear Experiment ,Beam (structure) ,media_common - Abstract
In photoproduction experiments, a large number of final states yielding various resonance contributions are accessible. To extract resonance parameters via partial-wave analysis not only the measurement of differential cross-sections is necessary, but also the determination of polarization observables. At the electron accelerator ELSA (Bonn) the coherent bremsstrahlung method was used to generate a linearly polarized photon beam. Using the CBELSA/TAPS detector setup, the beam asymmetry Σ in the reaction γp → pπ 0 η was determined as a function of various masses and angles for photon energies between 970MeV and 1650MeV.
- Published
- 2008
83. Eosinophils, pruritus and psoriasis: effects of treatment with etretinate or cyclosporin-A
- Author
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M. Bräutigam, T. Hultsch, J. Lotz, and R.E. Schopf
- Subjects
medicine.medical_specialty ,Eosinophil cationic protein ,business.industry ,Keratolytic ,Etretinate ,Dermatology ,medicine.disease ,Gastroenterology ,Blood proteins ,Proinflammatory cytokine ,Infectious Diseases ,Psoriasis ,Internal medicine ,Cyclosporin a ,Eosinophilic ,Immunology ,medicine ,business ,medicine.drug - Abstract
Background The antipsoriatic drugs cyclosporin A (CyA) and etretinate have been found to influence proinflammatory eosinophilic leukocytes and pruritus. Aim We compared the number of blood eosinophils, concentration of serum eosinophil cationic protein (ECP), and pruritus in patients with psoriasis treated with either CyA or etretinate. Study design Patients with psoriasis vulgaris were randomly assigned to treatment for 10 weeks with either CyA ( n =21) or etretinate ( n =10). The psoriasis area-and-severity index (PASI-score) and pruritus (according to a 0–3 scale) served as clinical parameters, the blood esosinophil counts (Coulter Counter) and the serum ECP (RIA, Pharmacia) as laboratory parameters. Results After CyA treatment the PASI-score amounted to 24±4%, after etretinate to 56±6% of the initial values (mean±SEM). One week after CyA treatment, esosinophils dropped from 190±21 to 137±16/ μ l ( P =0.038, Wilcoxon test), after 10 weeks to 127±18/ μ l ( P =0.006). By contrast, under etretinate blood eosinophil counts only changed marginally. Before treatment, ECP concentrations of 15.71±1.30 (CyA) and 15.3±5.53 μ g/l (etretinate) were measured (normal range 3–16 μ g/l), ECP remained constant under both CyA and etretinate or tended to increase after 10 weeks; about 50% of the patients exhibited elevated ECP concentrations. Pruritus diminished more with CyA than etretinate therapy. PASI-scores and pruritus were directly proportional. Outcome We conclude that treatment of psoriasis with CyA leads to a rapid drop of blood eosinophils and that the activation state of eosinophils does not decrease after antipsoriatic treatment. Pruritus in psoriasis is coupled to disease severity. The underlying antipsoriatic mechanisms of CyA may be linked to lowering the number of blood eosinophils.
- Published
- 1998
84. Diagnostik und Differentialdiagnostik von Lebertumoren
- Author
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J. Lotz, M. Prokop, M. Galanski, M. Jörgensen, D. Högemann, T. Kirchhoff, and S. Baus
- Subjects
business.industry ,Gastroenterology ,Medicine ,Surgery ,business - Published
- 1998
85. Development of multi-mission satellite data systems at the German Remote Sensing Data Centre
- Author
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H. J. Lotz-Iwen, G. Schreier, and W. Markwitz
- Subjects
Atmospheric Science ,Earth observation ,Remote sensing application ,business.industry ,Computer science ,Interoperability ,Aerospace Engineering ,Astronomy and Astrophysics ,Visualization ,Geophysics ,Space and Planetary Science ,Remote sensing (archaeology) ,Information system ,General Earth and Planetary Sciences ,Data center ,User interface ,business ,Remote sensing - Abstract
This paper focuses on conceptual aspects of the access to multi-mission remote sensing data by online catalogue and information systems. The system ISIS of the German Remote Sensing Data Centre is described as an example of a user interface to earth observation data. ISIS has been designed to support international scientific research as well as operational applications by offering online access to the database via public networks. It provides catalogue retrieval, visualisation and transfer of image data, and is integrated in international activities dedicated to catalogue and archive interoperability. Finally, an outlook is given on international projects dealing with access to remote sensing data in distributed archives.
- Published
- 1998
86. Vitaminstoffwechsel bei Patienten mit Mainz-Pouch-I
- Author
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Michael Stöckle, Margit Fisch, Y. Matani, R. Hohenfellner, I. Eisinger, Rolf Beetz, Raimund Stein, J. Lotz, and W. Prellwitz
- Subjects
medicine.medical_specialty ,business.industry ,Urology ,medicine.medical_treatment ,Urinary diversion ,medicine ,Vitamin B12 ,business - Abstract
Zur Konstruktion des Mainz-Pouch-I werden zwischen 24 und 36 cm des terminalen Ileums sowie ca. 12 cm Colon ascendens inkl. der Ileozökalklappe verwendet. Hierdurch entfällt ein Teil der Resorptionsfläche für Vitamine, Gallensäuren und Spurenlemente. Bei 137 Patienten mit einem Mainz-Pouch-I erfolgte die Bestimmung der Gallensäuren, der fett- und wasserlöslichen Vitamine (A, D, E, K, B1, B2, B6, B12), der Folsäure, des Ammoniaks und des Base excess, der Spurenelemente (Zink, Kupfer, Eisen), des Ferritins sowie eines Differentialblutbildes. Das Vitamin B12 und die Folsäure wurde zusätzlich intrakorpuskulär bestimmt. Kinder und Erwachsene wurden unterschieden und die Patienten in 3 Gruppen eingeteilt (0
- Published
- 1997
87. Abdominalchirurgisch relevante Aspekte des Suizidversuchs
- Author
-
J. Jähne, Konrad Obermann, J. Lotz, Rudolf Pichlmayr, A. Meyer zu Vilsendorf, and E. Nagel
- Subjects
Gynecology ,medicine.medical_specialty ,Cardiothoracic surgery ,business.industry ,medicine ,Surgery ,business - Abstract
Sowohl die abdominal-als auch die transplantationschirurgisch relevanten Aspekte des Suizidversuchs werden anhand der eigenen Patienten retrospektiv uber einen Zeitraum von 22 Jahren analysiert und dargestellt. Die Untersuchung der Methoden der Suizidversuche von 24 Patienten zeigte ein deutliches Uberwiegen der sog. harten (70%) gegenuber den weichen (30%) Methoden. Bei abdominalen Verletzungen aufgrund eines Suizidversuchs ist die Indikation zur Laparotomie in der Regel bei Stich- und Schusverletzungen mit meist guter Prognose nach der chirurgischen Behandlung gegeben. Bei Intoxikationen, insbesondere Laugenveratzungen, wird die Operationsindikation abhangig vom endoskopischen Befund und der Klinik des Patienten gestellt. Die deutlich erhohte Suizidgefahrdung bei Patienten mit terminaler Niereninsuffizienz kann durch eine Nierentransplantation signifikant gesenkt werden. Aufgrund verbesserter Immunsuppression und damit verbesserter Transplantatfunktion nimmt die Suizidgefahrdung nach Transplantation ab. In der Folge einer Paracetamolingestion in suizidaler Absicht ist nur in seltenen Fallen bei akutem Leberversagen eine Lebertransplantation indiziert, wobei in diesem Fall die auxiliare Lebertransplantation als Differentialeingriff zu erwagen ist.
- Published
- 1997
88. Evaluation and optimization of EGFR-based ADEPT, using non-invasive time-domain near-infrared fluorescence imaging
- Author
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Frauke Alves, T Krüwel, F Ramoz Gomes, Walter Stühmer, Joanna Napp, J Lotz, and Lutz F. Tietze
- Subjects
Pathology ,medicine.medical_specialty ,Cetuximab ,Chemistry ,Galactosidase activity ,Adept ,Prodrug ,In vitro ,Cell culture ,In vivo ,Cancer research ,medicine ,Radiology, Nuclear Medicine and imaging ,Ex vivo ,medicine.drug - Abstract
Ziele: The challenge facing cancer chemotherapy is the low selectivity to tumor cells versus normal cells. ADEPT (antibody-directed enzyme-prodrug therapy), in which a tumor specific antibody is used to carry a drug-activating enzyme to the tumor tissue, offers an attractive possibility to overcome this problem. Subsequent enzyme-mediated activation of nontoxic prodrugs to toxic drugs only within the tumor increases the specificity of treatment and decreases the drug toxicity in healthy tissues. Methode: The EGFR-targeting antibody Cetuximab was labeled with a near-infrared (NIR) fluorophore (Cetux-Alexa) and binding and internalization of the conjugate to mammary carcinoma cell lines with distinct EGFR expression patterns was analyzed in vitro. Distribution and binding-kinetics of Cetux-Alexa in nude mice bearing orthotopic mammary carcinomas were studied by NIR fluorescence imaging. Localization of the fluorescent probe within the tumor was analyzed ex vivo in tumor sections. To study the feasibility of Cetuximab for ADEPT, the antibody was conjugated with a drug activating enzyme, Galactosidase (Cetux-Gal). Ergebnis: Cetux-Alexa binds to EGFR-expressing cells in vitro and is localized to the cell membrane. In vivo, Cetux-Alexa targets EGFR-expressing tumors, resulting in a high tumor to background contrast. No unspecific accumulation of the fluorescence conjugate could be observed. Localization of Cetux-Alexa within the tumor was confirmed in tumor sections. Cetux-Gal was found to bind to EGFR-expressing cells in vitro specifically, proving a Galactosidase activity according to the distinct EGFR expression pattern. Subsequent addition of the prodrug showed toxicity proportional to the EGFR expression. Schlussfolgerung: A novel ADEPT treatment, in which tumor-bearing mice will be treated with Cetux-Gal in combination with a highly potent prodrug, was designed. In future experiments, the efficacy of the therapy will be assessed by monitoring tumor reduction with CT and SPECT using Tc-99 m labelled Cetuximab. Korrespondierender Autor: Kruwel T Universitatsmedizin Gottingen, Institut fur Diagnostische und Interventionelle Radiologie, Robert-Koch-Str. 40, 37075 Gottingen E-Mail: thomas.kruewel@med.uni-goettingen.de
- Published
- 2013
89. Fit für den Facharzt: Röntgenquiz - Herz
- Author
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C Unterberg and J Lotz
- Subjects
Radiology, Nuclear Medicine and imaging - Published
- 2013
90. [Cardiovascular radiology--an interdisciplinary approach]
- Author
-
J, Lotz, J, Barkhausen, and M, Gutberlet
- Subjects
Patient Care Team ,Cardiology ,Atherosclerosis ,Image Enhancement ,Magnetic Resonance Imaging ,Imaging, Three-Dimensional ,Cardiovascular Diseases ,Education, Medical, Graduate ,Image Interpretation, Computer-Assisted ,Humans ,Education, Medical, Continuing ,Interdisciplinary Communication ,Curriculum ,Cooperative Behavior ,Diffusion of Innovation ,Tomography, X-Ray Computed ,Total Quality Management - Published
- 2012
91. Discovery Channel Telescope software component template and state design: principles and implementation
- Author
-
Paul J. Lotz, Ryan C. Godwin, and Michael Lacasse
- Subjects
Finite-state machine ,Computer science ,Design pattern ,Separation of concerns ,Real-time computing ,Maintainability ,Active optics ,law.invention ,Telescope ,Computer architecture ,Observatory ,law ,Software design pattern ,Component-based software engineering ,Design process - Abstract
The Discovery Channel Telescope is a 4.3m astronomical research telescope in northern Arizona constructed through a partnership between Discovery Communications and Lowell Observatory. The control software for the telescope and observatory systems consists of stand-alone, state-based components that respond to triggers (external signals or internal data changes). Component applications execute on Windows, real-time, and FPGA targets. The team has developed a template for a system component, the implementation of which has yielded large gains in productivity, robustness, and maintainability. These benefits follow from the dependence of the template on common, well-tested code, allowing a developer to focus on application-specific particulars unencumbered by details of infrastructure elements such as communication, and from the separation of concerns the architecture provides, ensuring that modifications are straightforward, separable, and consequently relatively safe. We describe a repeatable design process for developing a state machine design, and show how this translates directly into a concrete implementation utilizing several design patterns, illustrating this with examples from components of the functioning active optics system. We also present a refined top-level state machine design and rules for highly independent component interactions within and between hierarchies that we propose offer a general solution for large component-based control systems.
- Published
- 2012
92. Status and performance of the Discovery Channel Telescope during commissioning
- Author
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Edward W. Dunham, Thomas A. Bida, Paul J. Lotz, P. Collins, Alexander Venetiou, Tomas Chylek, William T. DeGroff, Saeid Zoonemat Kermani, and Stephen E. Levine
- Subjects
Physics ,business.industry ,Reflecting telescope ,Astrophysics::Instrumentation and Methods for Astrophysics ,X-ray telescope ,Active optics ,First light ,law.invention ,Telescope ,Primary mirror ,Laser guide star ,Optics ,law ,business ,Secondary mirror - Abstract
Lowell Observatory's Discovery Channel Telescope is a 4.3m telescope designed for optical and near infrared astronomical observation. At first light, the telescope will have a cube capable of carrying five instruments and the wave front sensing and guider system at the f/6.1 RC focus. The corrected RC focus field of view is 30’ in diameter. Nasmyth and prime focus can be instrumented subsequently. Early commissioning work with the installed primary mirror and its support system started out using one of the wave front sensing probes mounted at prime focus, and has continued at RC with the recent installation of the secondary mirror. We will report on the on-sky pointing and tracking performance of the telescope, initial assessment of the functionality of the active optics support system, and tests of the early image quality of the telescope and optics. We will also describe the suite of first light instruments, and early science operations.
- Published
- 2012
93. Adjoining Hybrid Parallel Code
- Author
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M. Schanen, M. Foerster, J. Lotz, K. Leppkes, and U. Naumann
- Published
- 2012
94. Weiterbildung aus Sicht des Institutsleiters
- Author
-
J Lotz
- Subjects
Radiology, Nuclear Medicine and imaging - Published
- 2012
95. Innovative CT in der Paläopathologie - von der Abbildung zur funktionellen Analyse
- Author
-
Christian Dullin, M Schultz, Frauke Alves, J Missbach-Güntner, and J Lotz
- Subjects
Radiology, Nuclear Medicine and imaging - Published
- 2012
96. Neues aus klinischen Studien
- Author
-
J Lotz
- Subjects
Radiology, Nuclear Medicine and imaging - Published
- 2012
97. [Consensus recommendations of the German Radiology Society (DRG), the German Cardiac Society (DGK) and the German Society for Pediatric Cardiology (DGPK) on the use of cardiac imaging with computed tomography and magnetic resonance imaging]
- Author
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S, Achenbach, J, Barkhausen, M, Beer, P, Beerbaum, T, Dill, J, Eichhorn, S, Fratz, M, Gutberlet, M, Hoffmann, A, Huber, P, Hunold, C, Klein, G, Krombach, K-F, Kreitner, T, Kühne, J, Lotz, D, Maintz, H, Mahrholdt, H, Marholdt, N, Merkle, D, Messroghli, S, Miller, I, Paetsch, P, Radke, H, Steen, H, Thiele, S, Sarikouch, and R, Fischbach
- Subjects
Adult ,Heart Defects, Congenital ,Heart Diseases ,Infant ,Prognosis ,Magnetic Resonance Imaging ,Sensitivity and Specificity ,Cardiac Imaging Techniques ,Germany ,Humans ,Interdisciplinary Communication ,Cooperative Behavior ,Child ,Tomography, X-Ray Computed - Abstract
Cardiac magnetic resonance imaging (MRI) and computed tomography (CT) have been developed rapidly in the last decade. Technical improvements and broad availability of modern CT and MRI scanners have led to an increasing and regular use of both diagnostic methods in clinical routine. Therefore, this German consensus document has been developed in collaboration by the German Cardiac Society, German Radiology Society, and the German Society for Pediatric Cardiology. It is not oriented on modalities and methods, but rather on disease entities. This consensus document deals with coronary artery disease, cardiomyopathies, arrhythmias, valvular diseases, pericardial diseases and structural changes, as well as with congenital heart defects. For different clinical scenarios both imaging modalities CT and MRI are compared and evaluated in the specific context.
- Published
- 2012
98. Prognostischer Stellenwert der links-atrialen Dimensionen vor Pulmonalvenenisolation bei Patienten mit Vorhofflimmern: Vergleich zwischen Echokardiografie & Multidetektor-Computertomografie (MDCT)
- Author
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JM Sohns, W Staab, C Sohns, D Vollmann, L Lüthje, PA Zwaka, M Zabel, G Hasenfuß, and J Lotz
- Subjects
Radiology, Nuclear Medicine and imaging - Published
- 2012
99. Evaluation der Tumor-Vaskularisierung in Mäusen im zeitlichen Verlauf mittels innovativer CT-Technologien
- Author
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K Jannasch, Frauke Alves, J Missbach-Güntner, Christian Dullin, and J Lotz
- Subjects
Radiology, Nuclear Medicine and imaging - Published
- 2011
100. [An introduction to the cardiac and vascular diagnostics team]
- Author
-
S, Miller, M, Gutberlet, J, Lotz, R, Fischbach, and J, Barkhausen
- Subjects
Certification ,Heart Diseases ,Magnetic Resonance Imaging ,Europe ,Education, Medical, Graduate ,Germany ,Humans ,Interdisciplinary Communication ,Vascular Diseases ,Cooperative Behavior ,Diffusion of Innovation ,Radiology ,Tomography, X-Ray Computed ,Technology, Radiologic ,Magnetic Resonance Angiography ,Societies, Medical ,Forecasting ,Specialization - Published
- 2010
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