51. Hepatitis C: a possible etiology for cryoglobulinaemia type II
- Author
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Emiliano Giostra, P de Saussure, Jürg A. Schifferli, Luc Perrin, Widmann Jj, and A Pechère-Bertschi
- Subjects
Adult ,Liver Cirrhosis ,Male ,Cirrhosis ,Immunoblotting ,Molecular Sequence Data ,Immunology ,Hepacivirus ,Serology ,Liver Function Tests ,Immunopathology ,medicine ,Humans ,Immunology and Allergy ,Hepatitis Antibodies ,Transaminases ,Aged ,Hepatitis, Chronic ,Hepatitis ,Base Sequence ,medicine.diagnostic_test ,business.industry ,Gene Amplification ,RNA-Directed DNA Polymerase ,Hepatitis C ,Hepatitis C Antibodies ,Middle Aged ,medicine.disease ,Virology ,Reverse transcriptase ,Cryoglobulinemia ,Liver ,Liver biopsy ,Female ,Viral disease ,business ,Research Article - Abstract
SUMMARY Out of 15 successive patients with mixed essential cryoglobulinaemia type II (monoclonal IgM kappa /IgG), 13 had serological evidence for hepatitis C infection as shown by specific enzyme immunoassays and immunoblot. RNA was purified from the serum of seven patients and hepatitis C sequences were identified in five following reverse transcription and DNA amplification. The liver histology showed chronic active hepatitis with or without cirrhosis in the 12 patients with hepatitis C who had a liver biopsy. The two patients without serological evidence of hepatitis C suffered from haematological malignancies. Hepatitis C may be a major etiological agent of cryoglobulinaemia type II.
- Published
- 1992
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