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55. Longitudinal changes in 18F‐THK5351 positron emission tomography in corticobasal syndrome.

Author

Ezura, M., Kikuchi, A., Ishiki, A., Okamura, N., Hasegawa, T., Harada, R., Watanuki, S., Funaki, Y., Hiraoka, K., Baba, T., Sugeno, N., Oshima, R., Yoshida, S., Kobayashi, J., Kobayashi, M., Tano, O., Nakashima, I., Mugikura, S., Iwata, R., and Taki, Y.

Subjects
POSITRON emission tomography, MONOAMINE oxidase, MAGNETIC resonance imaging, NEUROGLIA, NEURODEGENERATION
Abstract

Background and purpose: Corticobasal syndrome (CBS) is pathologically characterized by tau deposits in neuronal and glial cells and by reactive astrogliosis. In several neurodegenerative disorders, 18F‐THK5351 has been observed to bind to reactive astrocytes expressing monoamine oxidase B. In this study, the aim was to investigate the progression of disease‐related pathology in the brains of patients with CBS using positron emission tomography with 18F‐THK5351. Methods: Baseline and 1‐year follow‐up imaging were acquired using magnetic resonance imaging and positron emission tomography with 18F‐THK5351 in 10 subjects: five patients with CBS and five age‐matched normal controls (NCs). Results: The 1‐year follow‐up scan images revealed that 18F‐THK5351 retention had significantly increased in the superior parietal gyrus of the patients with CBS compared with the NCs. The median increases in 18F‐THK5351 accumulation in the patients with CBS were 6.53% in the superior parietal gyrus, 4.34% in the precentral gyrus and 4.33% in the postcentral gyrus. In contrast, there was no significant increase in the regional 18F‐THK5351 retention in the NCs. Conclusions: Longitudinal increases in 18F‐THK5351 binding can be detected over a short interval in the cortical sites of patients with CBS. A monoamine oxidase B binding radiotracer could be useful in monitoring the progression of astrogliosis in CBS. [ABSTRACT FROM AUTHOR]

Published
2019
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83. Combined effect of 25-OH vitamin D plasma levels and genetic Vitamin D Receptor (NR 1I1) variants on fibrosis progression rate in HCV patients

Author

Baur, K, Mertens, J C, Schmitt, J, Iwata, R, Stieger, B, Eloranta, J J, Frei, P, Stickel, F, Dill, M T, Seifert, Burkhardt, Bischoff Ferrari, H A, von Eckardstein, A, Bochud, P Y, Müllhaupt, B, Geier, A, University of Zurich, and Geier, A

Subjects
10219 Clinic for Gastroenterology and Hepatology, 360 Social problems & social services, 300 Social sciences, sociology & anthropology, 11221 Clinic for Geriatric Medicine, 540 Chemistry, 610 Medicine & health, 2721 Hepatology
Published
2012

94. The role of bile acid retention and a common polymorphism in the ABCB11 gene as host factors affecting antiviral treatment response in chronic hepatitis C

Author

Iwata, R, Stieger, B, Mertens, J C, Müller, T, Baur, K, Frei, P, Braun, J, Vergopoulos, A, Martin, I V, Schmitt, J, Goetze, O, Bibert, S, Bochud, P Y, Müllhaupt, B, Berg, T, Geier, A, University of Zurich, and Geier, A

Subjects
10219 Clinic for Gastroenterology and Hepatology, 10199 Clinic for Clinical Pharmacology and Toxicology, 540 Chemistry, 2406 Virology, 610 Medicine & health, 2721 Hepatology, 2725 Infectious Diseases, 10038 Institute of Clinical Chemistry
Published
2011

95. A common polymorphism in the ABCB11 gene is associated with advanced fibrosis in hepatitis C but not in non-alcoholic fatty liver disease

Author

Iwata, R, Baur, K, Stieger, B, Mertens, J C, Daly, A K, Frei, P, Braun, J, Vergopoulos, A, Stickel, F, Sabrane, K, Martin, I V, Schmitt, J, Goetze, O, Day, C P, Müllhaupt, B, Geier, A, University of Zurich, and Geier, A

Subjects
10219 Clinic for Gastroenterology and Hepatology, 10199 Clinic for Clinical Pharmacology and Toxicology, 10076 Center for Integrative Human Physiology, U6 Integrative Human Physiology, 540 Chemistry, 570 Life sciences, biology, 610 Medicine & health, 2700 General Medicine, 10029 Clinic and Policlinic for Internal Medicine, 10038 Institute of Clinical Chemistry
Published
2011

96. Quantitative Imaging of 11C-Benztropine in Human Brain

Author

Fujiwara, T., Mejia, M., Itoh, M., Yanai, K., Watanabe, T., Meguro, K., Yamaguchi, S., Nakagawa, T., Sasaki, H., Ono, S., Goto, R., Itoh, H., Kinomura, S., Fukuda, H., Iwata, R., Takahasi, T., and Ido, T.

Abstract

開始ページ、終了ページ: 冊子体のページ付け

Published
1993

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