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1,918 results on '"Iung, Bernard"'

51. Aortic valve disease and heart failure with mildly reduced ejection fraction: New insights and pending questions.

Author

Suc, Gaspard and Iung, Bernard

Subjects
*HEART failure, *AORTIC valve diseases, *HEART valve diseases, *HEART valve prosthesis implantation, *CARDIAC patients, *CARDIAC magnetic resonance imaging, *VENTRICULAR ejection fraction
Abstract

The article discusses the relationship between aortic valve disease and heart failure with mildly reduced ejection fraction (HFmrEF). It highlights the importance of left ventricular ejection fraction (LVEF) as a prognostic factor and driver for intervention in valvular disease. The article also emphasizes the role of multimodality imaging in understanding LV remodeling and identifying other causes of LV dysfunction. The study by Schupp et al. provides insights into the risk stratification of HFmrEF patients with aortic valve disease, particularly aortic stenosis (AS). It suggests the need for improved knowledge of the interactions between valvular disease and LV function to optimize patient management. The article cautions against overinterpretation of the association between mild AS and poor outcomes, and highlights the underuse of interventions on the aortic valve in patients with severe AS and HFmrEF. It concludes by calling for further research to elucidate the underlying mechanisms of the association between valvular disease and impaired outcomes in HFmrEF patients. [Extracted from the article]

Published
2024
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52. Femoral Versus Nonfemoral Peripheral Access for Transcatheter Aortic Valve Replacement

Author

Beurtheret, Sylvain, Karam, Nicole, Resseguier, Noemie, Houel, Remi, Modine, Thomas, Folliguet, Thierry, Chamandi, Chekrallah, Com, Olivier, Gelisse, Richard, Bille, Jacques, Joly, Patrick, Barra, Nicolas, Tavildari, Alain, Commeau, Philippe, Armero, Sebastien, Pankert, Mathieu, Pansieri, Michel, Siame, Sabrina, Koning, René, Laskar, Marc, Le Dolley, Yvan, Maudiere, Arnaud, Villette, Bertrand, Khanoyan, Patrick, Seitz, Julien, Blanchard, Didier, Spaulding, Christian, Lefevre, Thierry, Van Belle, Eric, Gilard, Martine, Eltchaninoff, Helene, Iung, Bernard, Verhoye, Jean Philippe, Abi-Akar, Ramzi, Achouh, Paul, Cuisset, Thomas, Leprince, Pascal, Marijon, Eloi, Le Breton, Hervé, and Lafont, Antoine

Published
2019
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54. 2019 ESC/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk

Author

Mach, François, Baigent, Colin, Catapano, Alberico L., Koskinas, Konstantinos C., Casula, Manuela, Badimon, Lina, Chapman, M. John, De Backer, Guy G., Delgado, Victoria, Ference, Brian A., Graham, Ian M., Halliday, Alison, Landmesser, Ulf, Mihaylova, Borislava, Pedersen, Terje R., Riccardi, Gabriele, Richter, Dimitrios J., Sabatine, Marc S., Taskinen, Marja-Riitta, Tokgozoglu, Lale, Wiklund, Olov, Windecker, Stephan, Aboyans, Victor, Collet, Jean-Philippe, Dean, Veronica, Fitzsimons, Donna, Gale, Chris P., Grobbee, Diederick, Halvorsen, Sigrun, Hindricks, Gerhard, Iung, Bernard, Jüni, Peter, Katus, Hugo A., Leclercq, Christophe, Lettino, Maddalena, Lewis, Basil S., Merkely, Bela, Mueller, Christian, Petersen, Steffen, Petronio, Anna Sonia, Roffi, Marco, Shlyakhto, Evgeny, Simpson, Iain A., Sousa-Uva, Miguel, Touyz, Rhian M., Nibouche, Djamaleddine, Zelveian, Parounak H., Siostrzonek, Peter, Najafov, Ruslan, van de Borne, Philippe, Pojskic, Belma, Postadzhiyan, Arman, Kypris, Lambros, Špinar, Jindřich, Larsen, Mogens Lytken, Eldin, Hesham Salah, Viigimaa, Margus, Strandberg, Timo E., Ferrières, Jean, Agladze, Rusudan, Laufs, Ulrich, Rallidis, Loukianos, Bajnok, László, Gudjónsson, Thorbjörn, Maher, Vincent, Henkin, Yaakov, Gulizia, Michele Massimo, Mussagaliyeva, Aisulu, Bajraktari, Gani, Kerimkulova, Alina, Latkovskis, Gustavs, Hamoui, Omar, Slapikas, Rimvydas, Visser, Laurent, Dingli, Philip, Ivanov, Victoria, Boskovic, Aneta, Nazzi, Mbarek, Visseren, Frank, Mitevska, Irena, Retterstøl, Kjetil, Jankowski, Piotr, Fontes-Carvalho, Ricardo, Gaita, Dan, Ezhov, Marat, Foscoli, Marina, Giga, Vojislav, Pella, Daniel, Fras, Zlatko, Perez de Isla, Leopoldo, Hagström, Emil, Lehmann, Roger, Abid, Leila, Ozdogan, Oner, Mitchenko, Olena, and Patel, Riyaz S.

Published
2019
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57. The impact of transoesophageal echocardiography in elderly patients with infective endocarditis

Author

N’cho-Mottoh, Marie-Paule B, Erpelding, Marie-Line, Roubaud Baudron, Claire, Delahaye, François, Fraisse, Thibaut, Dijos, Marina, Ennezat, Pierre Vladimir, Fluttaz, Arnaud, Richard, Benjamin, Beaufort, Corinne, Nazeyrollas, Pierre, Brasselet, Camille, Pineau, Olivier, Tattevin, Pierre, Curlier, Elodie, Iung, Bernard, Forestier, Emmanuel, Selton-Suty, Christine, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre d'investigation clinique - Epidémiologie clinique [Nancy] (CIC-EC), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), CHU Bordeaux [Bordeaux], Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL), Centre Hospitalier Alès-Cévennes (CHAC), CHU Grenoble, Centre Hospitalier Métropole Savoie [Chambéry], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre Hospitalier Universitaire de Reims (CHU Reims), Centre Hospitalier Intercommunal Villeneuve-Saint-Georges (CHIV), CHU Pontchaillou [Rennes], ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pointe-à-Pitre/Abymes [Guadeloupe], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Cardiologie [CHRU Nancy], and The initial research project ELDERL-IE, from which these data were analysed, was supported by a grant of the 'Fondation Coeur et Recherche' (France) in 2013.

Subjects
Elderly, Transoesophageal echocardiography, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, General Medicine, Infective endocarditis, Cardiology and Cardiovascular Medicine, Geriatric assessment
Abstract

International audience; BACKGROUND: Infective endocarditis (IE) increasingly involves older patients. Geriatric status may influence diagnostic and therapeutic decisions. AIM: To describe transoesophageal echocardiography (TEE) use in elderly IE patients, and its impact on therapeutic management and mortality. METHODS: A multicentre prospective observational study (ELDERL-IE) included 120 patients aged ≥75 years with definite or possible IE: mean age 83.1±5.0; range 75-101 years; 56 females (46.7%). Patients had an initial comprehensive geriatric assessment, and 3-month and 1-year follow-up. Comparisons were made between patients who did or did not undergo TEE. RESULTS: Transthoracic echocardiography revealed IE-related abnormalities in 85 patients (70.8%). Only 77 patients (64.2%) had TEE. Patients without TEE were older (85.4±6.0 vs. 81.9±3.9 years; P=0.0011), had more comorbidities (Cumulative Illness Rating Scale-Geriatric score 17.9±7.8 vs. 12.8±6.7; P=0.0005), more often had no history of valvular disease (60.5% vs. 37.7%; P=0.0363), had a trend toward a higher Staphylococcus aureus infection rate (34.9% vs. 22.1%; P=0.13) and less often an abscess (4.7% vs. 22.1%; P=0.0122). Regarding the comprehensive geriatric assessment, patients without TEE had poorer functional, nutritional and cognitive statuses. Surgery was performed in 19 (15.8%) patients, all with TEE, was theoretically indicated but not performed in 15 (19.5%) patients with and 6 (14.0%) without TEE, and was not indicated in 43 (55.8%) patients with and 37 (86.0%) without TEE (P=0.0006). Mortality was significantly higher in patients without TEE. CONCLUSIONS: Despite similar IE features, surgical indication was less frequently recognized in patients without TEE, who less often had surgery and had a poorer prognosis. Cardiac lesions might have been underdiagnosed in the absence of TEE, hampering optimal therapeutic management. Advice of geriatricians should help cardiologists to better use TEE in elderly patients with suspected IE.

Published
2023

62. Time to blood culture positivity: An independent predictor of infective endocarditis and mortality in patients with Staphylococcus aureus bacteraemia

Author

Chirouze, Catherine, Curlier, Elodie, Descottes-Genon, Cécile, Hoen, Bruno, Patry, Isabelle, Vettoretti, Lucie, Chavanet, Pascal, Eicher, Jean-Christophe, Gohier-Treuvelot, Sandrine, Greusard, Marie-Christine, Neuwirth, Catherine, Péchinot, André, Piroth, Lionel, Célard, Marie, Cornu, Catherine, Delahaye, François, Hadid, Malika, Rausch, Pascale, Coma, Audrey, Galtier, Florence, Géraud, Philippe, Jean-Pierre, Hélène, Le Moing, Vincent, Sportouch, Catherine, Reynes, Jacques, Aissa, Nejla, Doco-Lecompte, Thanh, Goehringer, François, Keil, Nathalie, Letranchant, Lorraine, Malela, Hepher, May, Thierry, Selton-Suty, Christine, Bedos, Nathalie, Lavigne, Jean-Philippe, Lechiche, Catherine, Sotto, Albert, Duval, Xavier, Habensus, Emila Ilic, Iung, Bernard, Leport, Catherine, Longuet, Pascale, Ruimy, Raymond, Bellissant, Eric, Donnio, Pierre-Yves, Le Gac, Fabienne, Michelet, Christian, Revest, Matthieu, Tattevin, Pierre, Thebault, Elise, Alla, François, Braquet, Pierre, Erpelding, Marie-Line, Minary, Laetitia, Tubiana, Sarah, Bès, Michèle, Etienne, Jérôme, Lelekov-Boissard, Taissia, Tristan, Anne, Vandenesch, François, Van Belkum, Alex, Rivadeneira, Fernando, Vanwamel, Willem, Barbas, Sandrine, Delonca, Christine, Sussmuth, Virginie, Verchère, Anne, Siméon, S., Le Moing, V., Tubiana, S., Duval, X., Fournier, D., Lavigne, J.-P., Erpelding, M.-L., Gustave, C.-A., Desage, S., Chirouze, C., Vandenesch, F., and Tattevin, P.

Published
2019
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65. Impact of Direct Transcatheter Aortic Valve Replacement Without Balloon Aortic Valvuloplasty on Procedural and Clinical Outcomes: Insights From the FRANCE TAVI Registry

Author

Deharo, Pierre, Jaussaud, Nicolas, Grisoli, Dominique, Camus, Olivier, Resseguier, Noemie, Le Breton, Herve, Auffret, Vincent, Verhoye, Jean Philippe, Koning, René, Lefevre, Thierry, Van Belle, Eric, Eltchaninoff, Helene, Gilard, Martine, Leprince, Pascal, Iung, Bernard, Lambert, Marc, Collart, Frédéric, and Cuisset, Thomas

Published
2018
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66. Reducing length of stay after transfemoral transcatheter aortic valve implantation: the FAST-TAVI II trial.

Author

Durand, Eric, Beziau-Gasnier, Delphine, Michel, Morgane, Iung, Bernard, Tchetche, Didier, Bonnet, Guillaume, Lhermusier, Thibault, Gilard, Martine, Souteyrand, Geraud, Bouleti, Claire, Ohlmann, Patrick, Lefevre, Thierry, Beygui, Farzin, Chassaing, Stephan, Chevreul, Karine, Eltchaninoff, Hélène, II, FAST-TAVI, and investigators, STOP-AS

Subjects
HEART valve prosthesis implantation, AORTIC stenosis, HOSPITAL admission & discharge
Abstract

Background and Aims The length of stay (LOS) after transcatheter aortic valve implantation (TAVI) remains extremely variable whereas early discharge has been shown to be feasible and safe. The study objective was to evaluate the efficacy and safety of an intervention aimed at reducing LOS after transfemoral TAVI. Methods FAST-TAVI II is a prospective, multicentre, cluster, randomized, controlled study including patients with severe symptomatic aortic stenosis, who had transfemoral TAVI. The intervention consisted in a dedicated training programme to implement 10 quality of care measures to reduce LOS with an implementation phase of eight weeks. The primary endpoint was the proportion of patients discharged early within 3 days. Secondary endpoints included: LOS, 30-day mortality and 30-day incidence of readmission for cardiovascular events. Results During the study period, 969 patients were enrolled in the intervention group and 860 patients in the control group. Mean age was 81.9 ± 6.6 years and mean EuroSCORE II was 4.4 ± 4.5%. Early discharge was achieved in 563 (58.1%) patients in the intervention group vs. 364 (42.3%) patients in the control group (P <.0001). Median LOS was significantly reduced in the intervention group compared to the control group [3 (IQR: 3) vs. 4 days (IQR: 3), P <.0001]. Thirty-day mortality was low and similar in the two groups (0.5% vs. 0.9%, P =.30), as were 30-day readmissions (4.6% vs. 2.8%, P =.28). Conclusions The intervention was simple and fast to implement, and was effective and safe to reduce LOS and increase the proportion of patients discharged early after TAVI (NCT04503655). [ABSTRACT FROM AUTHOR]

Published
2024
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67. TRI-SCORE and benefit of intervention in patients with severe tricuspid regurgitation.

Author

Dreyfus, Julien, Galloo, Xavier, Taramasso, Maurizio, Heitzinger, Gregor, Benfari, Giovanni, Kresoja, Karl-Patrick, Juarez-Casso, Fernando, Omran, Hazem, Bohbot, Yohann, Iliadis, Christos, Russo, Giulio, Topilsky, Yan, Weber, Marcel, Nombela-Franco, Luis, Sala, Alessandra, Eixerés-Esteve, Andrea, Iung, Bernard, Obadia, Jean-François, Loureiro, Rodrigo Estevez, and Riant, Elisabeth

Subjects
TRICUSPID valve surgery, TRICUSPID valve insufficiency, OVERALL survival, SURVIVAL rate
Abstract

Background and aims Benefit of tricuspid regurgitation (TR) correction and timing of intervention are unclear. This study aimed to compare survival rates after surgical or transcatheter intervention to conservative management according to a TR clinical stage as assessed using the TRI-SCORE. Methods A total of 2,413 patients with severe isolated functional TR were enrolled in TRIGISTRY (1217 conservatively managed, 551 isolated tricuspid valve surgery, and 645 transcatheter valve repair). The primary endpoint was survival at 2 years. Results The TRI-SCORE was low (≤3) in 32%, intermediate (4–5) in 33%, and high (≥6) in 35%. A successful correction was achieved in 97% and 65% of patients in the surgical and transcatheter groups, respectively. Survival rates decreased with the TRI-SCORE in the three treatment groups (all P <.0001). In the low TRI-SCORE category, survival rates were higher in the surgical and transcatheter groups than in the conservative management group (93%, 87%, and 79%, respectively, P =.0002). In the intermediate category, no significant difference between groups was observed overall (80%, 71%, and 71%, respectively, P =.13) but benefit of the intervention became significant when the analysis was restricted to patients with successful correction (80%, 81%, and 71%, respectively, P =.009). In the high TRI-SCORE category, survival was not different to conservative management in the surgical and successful repair group (61% and 68% vs 58%, P =.26 and P =.18 respectively). Conclusions Survival progressively decreased with the TRI-SCORE irrespective of treatment modality. Compared to conservative management, an early and successful surgical or transcatheter intervention improved 2-year survival in patients at low and, to a lower extent, intermediate TRI-SCORE, while no benefit was observed in the high TRI-SCORE category. [ABSTRACT FROM AUTHOR]

Published
2024
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68. Management and outcomes of carcinoid heart disease with liver metastases of midgut neuroendocrine tumours.

Author

Suc, Gaspard, Cachier, Agnès, Hentic, Olivia, Bazire, Baptiste, Sannier, Aurélie, Delhomme, Clémence, Nataf, Patrick, Laschet, Jamila, Deschamps, Lydia, Garbarz, Eric, Ou, Phalla, Caligiuri, Giuseppina, Iung, Bernard, Ruszniewski, Philippe, de Mestier, Louis, and Arangalage, Dimitri

Subjects
VENTRICULAR ejection fraction, TRICUSPID valve diseases, HEART failure, HEART diseases, TRICUSPID valve surgery, NEUROENDOCRINE tumors, CARCINOID, LIVER diseases
Published
2024
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69. Predictive performance of surgical mortality risk scores in infective endocarditis.

Author

Hatimi, Safwane El, Erpelding, Marie-Line, Selton-Suty, Christine, Botros, Jean-Baptiste, Goehringer, François, Berthelot, Emmanuelle, Elfarra, Mazen, Deconinck, Laurène, Para, Marylou, Provenchere, Sophie, Hoen, Bruno, Agrinier, Nelly, Duval, Xavier, and Iung, Bernard

Subjects
DISEASE risk factors, INFECTIVE endocarditis, RECEIVER operating characteristic curves, ARTIFICIAL implants, HOSPITAL mortality, AORTIC valve
Abstract

Open in new tab Download slide OBJECTIVES This observational study aimed to evaluate Association pour l'Etude et la Prévention de l'Endocardite Infectieuse (AEPEI) surgery score predictive performance in comparison to general (EuroSCORE I, II) and specific (De Feo, PALSUSE) surgical risk scores for infective endocarditis (IE). METHODS The study included patients who underwent surgery for IE during the acute phase at Bichat University Hospital (Paris, France) between 1 January 2006 and 31 December 2016 and at Nancy University Hospital (Nancy, France) between 1 January 2009 and 31 December 2019. Patients with IE complicating percutaneous aortic valve implantations or implantable intra-cardiac devices were excluded. Discrimination and calibration were assessed using receiver operating characteristic curve analysis, calibration curves and the Hosmer–Lemeshow test. RESULTS In-hospital mortality rates were 18% at Bichat and 16% at Nancy. Discrimination was high for all risk scores at Bichat (area under the receiver operating characteristic curve = 0.77 for EuroSCORE I, 0.78 for EuroSCORE II, 0.76 for De Feo score, 0.72 for PALSUSE and 0.73 for AEPEI with 95% confidence interval ranging from 0.67 to 0.83), but lower at Nancy (0.56 for EuroSCORE I, 0.65 for EuroSCORE II, 0.63 for De Feo score, 0.67 for PALSUSE and 0.66 for AEPEI score with 95% confidence interval ranging from 0.47 to 0.75). With Brier score, all scores were adequately calibrated in both populations between 0.129 (De Feo) and 0.135 (PALSUSE) for Bichat and between 0.128 (De Feo) and 0.135 (EuroSCORE I) for Nancy. With the Hosmer–Lemeshow test, the AEPEI score exhibited the best calibration (observed/predicted ratio 1.058 in Bichat, 1.087 in Nancy). CONCLUSIONS This surgical score external validation in 2 large independent populations demonstrated that the AEPEI surgical score had the best predictive performance compared to other prognosis scores. It could be helpful in clinical practice to assist the endocarditis team in decision-making. [ABSTRACT FROM AUTHOR]

Published
2024
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72. Management and outcomes of carcinoid heart disease with liver metastases of midgut neuroendocrine tumours

Author

Suc, Gaspard, primary, Cachier, Agnès, additional, Hentic, Olivia, additional, Bazire, Baptiste, additional, Sannier, Aurélie, additional, Delhomme, Clémence, additional, Nataf, Patrick, additional, Laschet, Jamila, additional, Deschamps, Lydia, additional, Garbarz, Eric, additional, Ou, Phalla, additional, Caligiuri, Giuseppina, additional, Iung, Bernard, additional, Ruszniewski, Philippe, additional, de Mestier, Louis, additional, and Arangalage, Dimitri, additional

Published
2023
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77. Baseline characteristics and outcomes after transcatheter aortic-valve implantation in patients with or without previous balloon aortic valvuloplasty: Insights from the FRANCE 2 registry

Author

Bière, Loïc, Durfort, Amélie, Fouquet, Olivier, Hamel, Jean-François, Leprince, Pascal, Chevreul, Karine, Prat, Alain, Lievre, Michel, Donzeau-Gouge, Patrick, Fajadet, Jean, Teiger, Emmanuel, Eltchaninoff, Hélène, Iung, Bernard, Leguerrier, Alain, Gilard, Martine, and Furber, Alain

Published
2017
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78. Prevalence, clinical characteristics and outcomes of heart failure patients with or without isolated or combined mitral and tricuspid regurgitation: An analysis from the ESC‐HFA Heart Failure Long‐Term Registry

Author

Adamo, Marianna, primary, Chioncel, Ovidiu, additional, Benson, Lina, additional, Shahim, Bahira, additional, Crespo‐Leiro, Maria G., additional, Anker, Stefan D., additional, Coats, Andrew J.S., additional, Filippatos, Gerasimos, additional, Lainscak, Mitja, additional, McDonagh, Theresa, additional, Mebazaa, Alexander, additional, Piepoli, Massimo F., additional, Rosano, Giuseppe M.C., additional, Ruschitzka, Frank, additional, Savarese, Gianluigi, additional, Seferovic, Petar, additional, Shahim, Angiza, additional, Popescu, Bogdan A., additional, Iung, Bernard, additional, Volterrani, Maurizio, additional, Maggioni, Aldo P., additional, Metra, Marco, additional, and Lund, Lars H., additional

Published
2023
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79. Indoxyl-sulfate activation of the AhR- NF-κB pathway promotes interleukin-6 secretion and the subsequent osteogenic differentiation of human valvular interstitial cells from the aortic valve

Author

Candellier, Alexandre, primary, Issa, Nervana, additional, Grissi, Maria, additional, Brouette, Théo, additional, Avondo, Carine, additional, Gomila, Cathy, additional, Blot, Gérémy, additional, Gubler, Brigitte, additional, Touati, Gilles, additional, Bennis, Youssef, additional, Caus, Thierry, additional, Brazier, Michel, additional, Choukroun, Gabriel, additional, Tribouilloy, Christophe, additional, Kamel, Saïd, additional, Boudot, Cédric, additional, Hénaut, Lucie, additional, Eltchaninoff, Hélène, additional, Bellien, Jérémy, additional, Bertrand, Benjamin, additional, Beygui, Farzin, additional, Béziau-Gasnier, Delphine, additional, Brakenhielm, Ebba, additional, Caligiuri, Giuseppina, additional, Chevreul, Karine, additional, Debroucker, Frédérique, additional, Durand, Eric, additional, Fraschini, Christophe, additional, Gilard, Martine, additional, Iung, Bernard, additional, Kamel, Said, additional, Laschet, Jamila, additional, Manrique, Alain, additional, Messas, Emmanuel, additional, Messika-Zeitoun, David, additional, Pinet, Florence, additional, Richard, Vincent, additional, Saloux, Eric, additional, Thoenes, Martin, additional, and Vézier, Claire, additional

Published
2023
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82. The impact of transoesophageal echocardiography in elderly patients with infective endocarditis

Author

N'cho-Mottoh, Marie-Paule B., primary, Erpelding, Marie-Line, additional, Roubaud, Claire, additional, Delahaye, François, additional, Fraisse, Thibaut, additional, Dijos, Marina, additional, Ennezat, Pierre-Vladimir, additional, Fluttaz, Arnaud, additional, Richard, Benjamin, additional, Beaufort, Corinne, additional, Nazeyrollas, Pierre, additional, Brasselet, Camille, additional, Pineau, Olivier, additional, Tattevin, Pierre, additional, Curlier, Elodie, additional, Iung, Bernard, additional, Forestier, Emmanuel, additional, and Selton-Suty, Christine, additional

Published
2023
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86. Position paper for the evaluation and management of oral status in patients with valvular disease: Groupe de Travail Valvulopathies de la Société Française de Cardiologie, Société Française de Chirurgie Orale, Société Française de Parodontologie et d’Implantologie Orale, Société Française d’Endodontie et Société de Pathologie Infectieuse de Langue Française

Author

Millot, Sarah, Lesclous, Philippe, Colombier, Marie-Laure, Radoi, Loredana, Messeca, Clément, Ballanger, Mathieu, Charrier, Jean-Luc, Tramba, Philippe, Simon, Stéphane, Berrebi, Alain, Doguet, Fabien, Lansac, Emmanuel, Tribouilloy, Christophe, Habib, Gilbert, Duval, Xavier, and Iung, Bernard

Published
2017
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87. Asymptomatic Severe and Moderate Aortic Stenosis:Time for Appraisal of Treatment Indications

Author

Banovic, Marko, Iung, Bernard, Wojakowski, Wojtek, Van Mieghem, Nicholas, Bartunek, Jozef, Banovic, Marko, Iung, Bernard, Wojakowski, Wojtek, Van Mieghem, Nicholas, and Bartunek, Jozef

Abstract

Over the last decades, we have witnessed considerable improvements in diagnostics and risk stratification of patients with significant aortic stenosis (AS), paralleled by advances in operative and anesthetic techniques. In addition, accumulating evidence points to the potential benefit of early valve replacement in such patients prior to the onset of symptoms. In parallel, interventional randomized trials have proven the benefit of transcatheter aortic valve replacement in comparison to a surgical approach to valve replacement over a broad risk spectrum in symptomatic patients with AS. This article reviews contemporary management approaches and scrutinizes open questions regarding timing and mode of intervention in asymptomatic patients with severe AS. We also discuss the challenges surrounding the management of symptomatic patients with moderate AS as well as emerging dilemmas related to the concept of a life-long treatment strategy for patients with AS.

Published
2023

88. Rationale and design of the ESC Heart Failure III Registry - Implementation and discovery

Author

Lund, Lars H; https://orcid.org/0000-0003-1411-4482, Crespo-Leiro, Maria Generosa, Laroche, Cecile, Garcia-Pinilla, Jose M, Bennis, Ahmed, Vataman, Eleonora B, Polovina, Marija, Radovanovic, Slavica, Apostolovic, Svetlana R, Ašanin, Milika, Gackowski, Andrzej, Kaplon-Cieslicka, Agnieszka, Cabac-Pogorevici, Irina, Anker, Stefan D, Chioncel, Ovidiu; https://orcid.org/0000-0002-3197-3628, Coats, Andrew J S; https://orcid.org/0000-0002-2771-4260, Filippatos, Gerasimos; https://orcid.org/0000-0002-5640-0332, Lainscak, Mitja; https://orcid.org/0000-0002-5922-4098, McDonagh, Theresa; https://orcid.org/0000-0003-1305-9602, Mebazaa, Alexandre, Metra, Marco; https://orcid.org/0000-0001-6691-8568, Piepoli, Massimo; https://orcid.org/0000-0003-1124-234X, Rosano, Giuseppe M, Ruschitzka, Frank; https://orcid.org/0000-0001-5972-0596, Savarese, Gianluigi; https://orcid.org/0000-0001-7732-0887, Seferović, Petar M, Iung, Bernard; https://orcid.org/0000-0002-9127-348X, Popescu, Bogdan A; https://orcid.org/0000-0001-6122-8533, Maggioni, Aldo P; https://orcid.org/0000-0003-2764-6779, ESC EORP HF III National Leaders and Investigators, Lund, Lars H; https://orcid.org/0000-0003-1411-4482, Crespo-Leiro, Maria Generosa, Laroche, Cecile, Garcia-Pinilla, Jose M, Bennis, Ahmed, Vataman, Eleonora B, Polovina, Marija, Radovanovic, Slavica, Apostolovic, Svetlana R, Ašanin, Milika, Gackowski, Andrzej, Kaplon-Cieslicka, Agnieszka, Cabac-Pogorevici, Irina, Anker, Stefan D, Chioncel, Ovidiu; https://orcid.org/0000-0002-3197-3628, Coats, Andrew J S; https://orcid.org/0000-0002-2771-4260, Filippatos, Gerasimos; https://orcid.org/0000-0002-5640-0332, Lainscak, Mitja; https://orcid.org/0000-0002-5922-4098, McDonagh, Theresa; https://orcid.org/0000-0003-1305-9602, Mebazaa, Alexandre, Metra, Marco; https://orcid.org/0000-0001-6691-8568, Piepoli, Massimo; https://orcid.org/0000-0003-1124-234X, Rosano, Giuseppe M, Ruschitzka, Frank; https://orcid.org/0000-0001-5972-0596, Savarese, Gianluigi; https://orcid.org/0000-0001-7732-0887, Seferović, Petar M, Iung, Bernard; https://orcid.org/0000-0002-9127-348X, Popescu, Bogdan A; https://orcid.org/0000-0001-6122-8533, Maggioni, Aldo P; https://orcid.org/0000-0003-2764-6779, and ESC EORP HF III National Leaders and Investigators

Abstract

AIMS Heart failure outcomes remain poor despite advances in therapy. The European Society of Cardiology Heart Failure III Registry (ESC HF III Registry) aims to characterize HF clinical features and outcomes and to assess implementation of guideline-recommended therapy in Europe and other ESC affiliated countries. METHODS Between 1 November 2018 and 31 December 2020, 10 162 patients with chronic or acute/worsening HF with reduced, mildly reduced, or preserved ejection fraction were enrolled from 220 centres in 41 European or ESC affiliated countries. The ESC HF III Registry collected data on baseline characteristics (hospital or clinic presentation), hospital course, diagnostic and therapeutic decisions in hospital and at the clinic visit; and on outcomes at 12-month follow-up. These data include demographics, medical history, physical examination, biomarkers and imaging, quality of life, treatments, and interventions - including drug doses and reasons for non-use, and cause-specific outcomes. CONCLUSION The ESC HF III Registry will provide comprehensive and unique insight into contemporary HF characteristics, treatment implementation, and outcomes, and may impact implementation strategies, clinical discovery, trial design, and public policy.

Published
2023

89. Predictors of embolism and death in left-sided infective endocarditis: the European Society of Cardiology EURObservational Research Programme European Infective Endocarditis registry.

Author

Sambola, Antonia, Lozano-Torres, Jordi, Boersma, Eric, Olmos, Carmen, Ternacle, Julien, Calvo, Francisco, Tribouilloy, Christophe, Reskovic-Luksic, Vlatka, Separovic-Hanzevacki, Jadranka, Park, Seung-Woo, Bekkers, Sebastiaan, Chan, Kwan-Leung, Almaghraby, Abdallah, Iung, Bernard, Lancellotti, Patrizio, Habib, Gilbert, and Group, the ESC EORP EURO-ENDO Registry Investigator

Subjects
INFECTIVE endocarditis, CARDIAC research, CONGESTIVE heart failure, LOGISTIC regression analysis, CARDIOGENIC shock
Abstract

Background and Aims Even though vegetation size in infective endocarditis (IE) has been associated with embolic events (EEs) and mortality risk, it is unclear whether vegetation size associated with these potential outcomes is different in left-sided IE (LSIE). This study aimed to seek assessing the vegetation cut-off size as predictor of EE or 30-day mortality for LSIE and to determine risk predictors of these outcomes. Methods The European Society of Cardiology EURObservational Research Programme European Infective Endocarditis is a prospective, multicentre registry including patients with definite or possible IE throughout 2016–18. Cox multivariable logistic regression analysis was performed to assess variables associated with EE or 30-day mortality. Results There were 2171 patients with LSIE (women 31.5%). Among these affected patients, 459 (21.1%) had a new EE or died in 30 days. The cut-off value of vegetation size for predicting EEs or 30-day mortality was >10 mm [hazard ratio (HR) 1.38, 95% confidence interval (CI) 1.13–1.69, P =.0015]. Other adjusted predictors of risk of EE or death were as follows: EE on admission (HR 1.89, 95% CI 1.54–2.33, P <.0001), history of heart failure (HR 1.53, 95% CI 1.21–1.93, P =.0004), creatinine >2 mg/dL (HR 1.59, 95% CI 1.25–2.03, P =.0002), Staphylococcus aureus (HR 1.36, 95% CI 1.08–1.70, P =.008), congestive heart failure (HR 1.40, 95% CI 1.12–1.75, P =.003), presence of haemorrhagic stroke (HR 4.57, 95% CI 3.08–6.79, P <.0001), alcohol abuse (HR 1.45, 95% CI 1.04–2.03, P =.03), presence of cardiogenic shock (HR 2.07, 95% CI 1.29–3.34, P =.003), and not performing left surgery (HR 1.30 95% CI 1.05–1.61, P =.016) (C -statistic =.68). Conclusions Prognosis after LSIE is determined by multiple factors, including vegetation size. [ABSTRACT FROM AUTHOR]

Published
2023
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90. Absence of infective endocarditis relapse when end-of-treatment fluorodeoxyglucose positron emission tomography/computed tomography is negative.

Author

Régis, Claudine, Thy, Michael, Mahida, Besma, Deconinck, Laurène, Tubiana, Sarah, Iung, Bernard, Duval, Xavier, and Rouzet, François

Subjects
ANTIBIOTICS, ENDOCARDITIS, QUANTITATIVE research, DISEASE relapse, QUALITATIVE research, RADIOPHARMACEUTICALS, POSITRON emission tomography, PROSTHETIC heart valves, DESCRIPTIVE statistics, DEOXY sugars, COMPUTED tomography, DISEASE risk factors
Abstract

Aims In non-operated infective endocarditis (IE), relapse may impair the outcome of the disease. The aim of the study was to evaluate the relationship between end-of-treatment (EOT) fluorodeoxyglucose positron emission tomography/computed tomography FDG-PET/CT results and relapse in non-operated IE either on native or prosthetic valve. Methods and results We included 62 patients who underwent an EOT FDG-PET/CT for non-operated IE performed between 30 and 180 days of antibiotic therapy initiation. Qualitative valve assessment categorized initial and EOT FDG-PET/CT as negative or positive. Quantitative analyses were also conducted. Clinical data from medical charts were collected, including endocarditis team decision for IE diagnosis and relapse. Forty-one (66%) patients were male with a median age of 68 years (57; 80) and 42 (68%) had prosthetic valve IE. End-of-treatment FDG-PET/CT was negative in 29 and positive in 33 patients. The proportion of positive scans decreased significantly compared with initial FDG-PET/CT (53% vs. 77%, respectively, P < 0.0001). All relapses (n = 7, 11%) occurred in patients with a positive EOT FDG-PET/CT with a median delay after EOT FDG-PET/CT of 10 days (0; 45). The relapse rate was significantly lower in negative (0/29) than in positive (7/33) EOT FDG-PET/CT (P = 0.01). Conclusion In this series of 62 patients with non-operated IE who underwent EOT FDG-PET/CT, those with a negative scan (almost half of the study population) did not develop IE relapse after a median follow-up of 10 months. These findings need to be confirmed by prospective and larger studies. [ABSTRACT FROM AUTHOR]

Published
2023
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92. Balloon-Expandable Versus Self-Expanding Transcatheter Aortic Valve Replacement: A Propensity-Matched Comparison From the FRANCE-TAVI Registry

Author

Van Belle, Eric, Vincent, Flavien, Labreuche, Julien, Auffret, Vincent, Debry, Nicolas, Lefèvre, Thierry, Eltchaninoff, Helene, Manigold, Thibaut, Gilard, Martine, Verhoye, Jean-Phillipe, Himbert, Dominique, Koning, Rene, Collet, Jean-Phillipe, Leprince, Pascal, Teiger, Emmanuel, Duhamel, Alain, Cosenza, Alessandro, Schurtz, Guillaume, Porouchani, Sina, Lattuca, Benoit, Robin, Emmanuel, Coisne, Augustin, Modine, Thomas, Richardson, Marjorie, Joly, Patrick, Rioufol, Gilles, Ghostine, Said, Bar, Olivier, Amabile, Nicolas, Champagnac, Didier, Ohlmann, Patrick, Meneveau, Nicolas, Lhermusier, Thibaut, Leroux, Lionel, Leclercq, Florence, Gandet, Thomas, Pinaud, Frédéric, Cuisset, Thomas, Motreff, Pascal, Souteyrand, Géraud, Iung, Bernard, Folliguet, Thierry, Commeau, Philippe, Cayla, Guillaume, Bayet, Gilles, Darremont, Olivier, Spaulding, Christian, Le Breton, Hervé, and Delhaye, Cédric

Published
2020
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96. Contemporary Presentation and Management of Valvular Heart Disease: The EURObservational Research Programme Valvular Heart Disease II Survey

Author

Iung, Bernard, Delgado, Victoria, Rosenhek, Raphael, Price, Susanna, Prendergast, Bernard, Wendler, Olaf, De Bonis, Michele, Tribouilloy, Christophe, Evangelista, Arturo, Bogachev-Prokophiev, Alexander, Apor, Astrid, Ince, Hüseyin, Laroche, Cécile, Popescu, Bogdan A., Piérard, Luc, Haude, Michael, Hindricks, Gerhard, Ruschitzka, Frank, Windecker, Stefan, Bax, Jeroen J., Maggioni, Aldo, Vahanian, Alec, Goda, Artan, Mascherbauer, Julia, Samadov, Fuad, Pasquet, Agnes, Linhartova, Katerina, Ihlemann, Nikolaj, Abdelhamid, Magdy, Saraste, Antti, Tribouilloy, Christophe, Kostovska, Elizabeta Srbinovska, Bajraktari, Gani, Mirrakhimov, Erkin, Erglis, Andrejs, Mizariene, Vaida, Cassar, Daniela, Delgado, Victoria, Tomkiewicz-Pajak, Lidia, Ribeiras, Regina, Beleslin, Branko, Simkova, Iveta, Evangelista, Arturo, Dogan, Sait Mesut, and Rahman-Haley, Shelley

Published
2019
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97. Guía ESC 2020 para el tratamiento de las cardiopatías congénitas del adulto

Author

Baumgartner, Helmut, De Backer, Julie, Babu-Narayan, Sonya V., Budts, Werner, Chessa, Massimo, Diller, Gerhard-Paul, Iung, Bernard, Kluin, Jolanda, Lang, Irene M., Meijboom, Folkert, Moons, Philip, Mulder, Barbara J.M., Oechslin, Erwin, Roos-Hesselink, Jolien W., Schwerzmann, Markus, Sondergaard, Lars, Zeppenfeld, Katja, Ernst, Sabine, Ladouceur, Magalie, Aboyans, Victor, Alexander, David, Christodorescu, Ruxandra, Corrado, Domenico, D’Alto, Michele, de Groot, Natasja, Delgado, Victoria, Di Salvo, Giovanni, Dos Subira, Laura, Eicken, Andreas, Fitzsimons, Donna, Frogoudaki, Alexandra A., Gatzoulis, Michael, Heymans, Stephane, Hörer, Jürgen, Houyel, Lucile, Jondeau, Guillaume, Katus, Hugo A., Landmesser, Ulf, Lewis, Basil S., Lyon, Alexander, Mueller, Christian E., Mylotte, Darren, Petersen, Steffen E., Petronio, Anna Sonia, Roffi, Marco, Rosenhek, Raphael, Shlyakhto, Evgeny, Simpson, Iain A., Sousa-Uva, Miguel, Torp-Pedersen, Christian Tobias, Touyz, Rhian M., and Van De Bruaene, Alexander

Published
2021
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100. Evolution of TAVI patients and techniques over the past decade: The French TAVI registries

Author

Didier, Romain, Le Breton, Herve, Eltchaninoff, Helene, Cayla, Guillaume, Commeau, Philippe, Collet, Jean-Philippe, Cuisset, Thomas, Dumonteil, Nicolas, Verhoye, Jean-Philippe, Beurtheret, Sylvain, Lefevre, Thierry, Iung, Bernard, Gilard, Martine, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Service de cardiologie [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital de la Timone [CHU - APHM] (TIMONE), Clinique Pasteur [Toulouse], Hôpital Saint-Joseph [Marseille], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), French Government, man-aged by the National Research Agency (ANR) [ANR-16-RHUS-0003], and ANR-16-RHUS-0003,STOP-AS,STOP-AS(2016)

Subjects
Aged, 80 and over, Transcatheter aortic valve implantation, Time Factors, Outcomes, Aortic Valve Stenosis, General Medicine, Evolution over time, Transcatheter Aortic Valve Replacement, Treatment Outcome, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Risk Factors, Aortic Valve, Humans, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Registries, Cardiology and Cardiovascular Medicine
Abstract

International audience; Background. - The French transcatheter aortic valve implantation (TAVI) registries, linked with the nationwide administrative databases, have collected data on TAVI procedures from the first experience to current practices.Objective. - To investigate changes over the past decade in patient and procedural characteristics, major complications and mortality after TAVI.Methods. - Data from the France TAVI and FRANCE 2 registries, collected between 2010 and 2021, were linked using a probabilistic algorithm to the French national health single-payer claims database (SNDS). The algorithm created patient profiles from TAVI procedures in SNDS, matching them as closely as possible to the profiles in the registry databases.Results. - A total of 84,783 TAVI patients were included during the study period. The median age was 83 years (quartile 1, 79 years; quartile 3, 87 years) and remained stable over time. The median EuroSCORE 1 surgical risk score was 12.8 (quartile 1, 7.9; quartile 3, 21.0), and decreased over time. The number of procedures increased linearly, from 1556 in 2010 to 14,114 in 2021. The prevalence of iliofemoral access increased, whereas use of the other approaches decreased. Rates of in-hospital, 30-day and 1-year mortality per year were lower in patients undergoing TAVI after 2015, regardless of the surgical risk score. Finally, hospital length of stay decreased progressively, from 8 days in 2010 to 4 days in 2021.Conclusion. - The TAVI registries provide the cornerstone for recording changes in TAVI. Over the past decade, patient profiles have improved whereas their age has remained stable. Simplification of the procedure reduced rates of death and major complications as well as length of hospital stay.

Published
2022

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