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54. High-mobility group box 1 is involved in the initial events of early loss of transplanted islets in mice

Author

Matsuoka, Nobuhide, Itoh, Takeshi, Watarai, Hiroshi, Sekine-Kondo, Etsuko, Nagata, Naoki, Okamoto, Kohji, Mera, Toshiyuki, Yamamoto, Hiroshi, Yamada, Shingo, Maruyama, Ikuro, Taniguchi, Masaru, and Yasunami, Yohichi

Subjects
Pancreatic beta cells -- Transplantation, Type 1 diabetes -- Risk factors -- Genetic aspects -- Care and treatment -- Research, Health care industry
Abstract

Islet transplantation for the treatment of type 1 diabetes mellitus is limited in its clinical application mainly due to early loss of the transplanted islets, resulting in low transplantation efficiency. NKT cell-dependent IFN-γ production by [Gr-1.sup.+][CD11b.sup.+] cells is essential for this loss, but the upstream events in the process remain undetermined. Here, we have demonstrated that high-mobility group box 1 (HMGB1) plays a crucial role in the initial events of early loss of transplanted islets in a mouse model of diabetes. Pancreatic islets contained abundant HMGB1, which was released into the circulation soon after islet transplantation into the liver. Treatment with an HMGB1-specific antibody prevented the early islet graft loss and inhibited IFN-γ production by NKT cells and [Gr-1.sup.+][CD11b.sup.+] cells. Moreover, mice lacking either of the known HMGB1 receptors TLR2 or receptor for advanced glycation end products (RAGE), but not the known HMGB1 receptor TLR4, failed to exhibit early islet graft loss. Mechanistically, HMGB1 stimulated hepatic mononuclear cells (MNCs) in vivo and in vitro; in particular, it upregulated CD40 expression and enhanced IL-12 production by DCs, leading to NKT cell activation and subsequent NKT cell-dependent augmented IFN-γ production by [Gr-1.sup.+][CD11b.sup.+] cells. Thus, treatment with either IL-12- or CD40L-specific antibody prevented the early islet graft loss. These findings indicate that the HMGB1-mediated pathway eliciting early islet loss is a potential target for intervention to improve the efficiency of islet transplantation., Introduction Pancreatic islet transplantation, although an attractive procedure for the treatment of type 1 diabetes mellitus, usually fails to achieve insulin independence of a diabetic recipient from a single donor [...]

Published
2010
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58. The Promoter Signatures in Rice LEA Genes Can Be Used to Build a Co-expressing LEA Gene Network

Author

Meier, Stuart, Gehring, Chris, MacPherson, Cameron Ross, Kaur, Mandeep, Maqungo, Monique, Reuben, Sheela, Muyanga, Samson, Shih, Ming-Der, Wei, Fu-Jin, Wanchana, Samart, Mauleon, Ramil, Radovanovic, Aleksandar, Bruskiewich, Richard, Tanaka, Tsuyoshi, Mohanty, Bijayalaxmi, Itoh, Takeshi, Wing, Rod, Gojobori, Takashi, Sasaki, Takuji, Swarup, Sanjay, Hsing, Yue-ie, and Bajic, Vladimir B.

Published
2008
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60. Additional file 1 of Simultaneous induction of mutant alleles of two allergenic genes in soybean by using site-directed mutagenesis

Author

Sugano, Shota, Hirose, Aya, Kanazashi, Yuhei, Adachi, Kohei, Hibara, Miki, Itoh, Takeshi, Mikami, Masafumi, Endo, Masaki, Hirose, Sakiko, Maruyama, Nobuyuki, Abe, Jun, and Yamada, Tetsuya

Abstract

Additional file 1: Table S1. Induction of mutations in the targeted loci and the integration of the Cas9 gene in representative T1 plants from the transformation of Enrei. Table S2. Induction of mutations in the targeted loci and the integration of the Cas9 gene in representative T1 plants from the transformation of Kariyutaka. Table S3. Primer sequences used for vector construction, confirmation of transgenes, and CAPS, semi-quantitative RT-PCR, and sequencing analyses.

Published
2020
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61. Additional file 2 of Simultaneous induction of mutant alleles of two allergenic genes in soybean by using site-directed mutagenesis

Author

Sugano, Shota, Hirose, Aya, Kanazashi, Yuhei, Adachi, Kohei, Hibara, Miki, Itoh, Takeshi, Mikami, Masafumi, Endo, Masaki, Hirose, Sakiko, Maruyama, Nobuyuki, Abe, Jun, and Yamada, Tetsuya

Subjects
animal structures, integumentary system
Abstract

Additional file 2: Figure S1. Confirmation of mutagenesis of targeted loci in representative Kariuytaka-T1 plants by CAPS analysis. Figure S2. Detection of mutations in the Gly m Bd 28K and Gly m Bd 30K loci in representative Enrei-T2 seeds by CAPS analysis. Figure S3. Detection of mutations in the Gly m Bd 28K and Gly m Bd 30K loci in representative Kariyutka-T2 seeds by CAPS analysis. Figure S4. Detection of the integration of the Cas9 gene in representative T2 seeds by PCR analysis. Figure S5. Mutational spectra of the targeted loci in double-mutant T3 seeds. Figure S6. Alignment of predicted amino acid sequences of the Gly m Bd 28K locus in double mutants. Figure S7. Alignment of predicted amino acid sequences of the Gly m Bd 30K locus in double mutants. Figure S8. Full-length gel electrophoresis and immunoblot of the crude protein of representative double-mutant T3 and wild-type mature seeds. Figure S9. Primer sites used for semi-quantitative RT-PCR analysis of the Gly m Bd 30K and the Gly m Bd 30K loci. Figure S10. Morphological characteristics of representative double-mutant (T2) and control Kariyutaka plants. Figure S11. Morphological characteristics of representative double-mutant (T3) and control Kariyutaka seeds.

Published
2020
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65. A Functional Analysis of Postposing of Prepositions in Old English

Author

Itoh, Takeshi

Subjects
自然音韻論, 情報の流れ, 前置詞後置, 不変化詞移動
Abstract

現代英語では見られない前置詞の後置現象がKing Edmund のような古英語作品においてたびたび観察される。本研究では, 古英語においては, 前置詞とその目的語が隣接していなければならないという制約が緩く, 副詞的な振る舞いをみせていたという事実から, 現代英語における不変化詞移動と類似した現象として捉える可能性を示唆し, 文法組織の違いこそあるものの, 旧い情報から新しい情報へと進行する情報の流れと同じ原理が古英語における前置詞後置を引き起こしている可能性を提示した。

Published
2018

67. Developments of a new 1-dimensional [gamma]-ray position sensor using scintillators coupled to a Si strip detector

Author

Itoh, Takeshi, Kokubun, Motohide, Takashima, Takeshi, Honda, Tsuneo, Makishima, Kazuo, Tanaka, Takaaki, Yanagida, Takayuki, Hirakuri, Shinya, Miyawaki, Ryohei, Takahashi, Hiromitsu, Nakazawa, Kazuhiro, and Takahashi, Tadayuki

Subjects
Sensors -- Usage, Radiography -- Usage, Gamma rays -- Research, Business, Electronics, Electronics and electrical industries
Abstract

In order to operate an 'improved' Fourier synthesis imager at higher photon energies than are accessible with solidstate detectors, we developed a new one-dimensional [gamma]-ray position sensor consisting of inorganic scintillators whose light is read out by a silicon strip detector (SSD). The SSD is read out through stripped p-electrodes (DC-coupled, 32 channels at 400 [micro]m pitch). The n-side of the SSD does not have a metallic surface, and has a relatively good optical transparancy. A stack of optically isolated thin CsI(TI) scintillator plates (10 mm x 10 mm in area and 0.3 mm thick) is attached, edge-on, to the n-side of the SSD. When a [gamma]-ray photon hits the stacked scintillator, the generated scintillation light is detected by the SSD, with the signal pulse-height largest in the p-electrode which is just beneath the CsI plate hit by the [gamma]-ray. The 32-channel outputs from the SSD are acquired simultaneously for each event with a low-noise analog ASIC. The [gamma]-ray position can be calculated as a weighted mean of pulse heights. Using this system, we have obtained a position resolution significantly finer than 1 mm for v-rays with energies greater than ~500 keV up to ~1300 keV. Index Terms--Inorganic scintillator, silicon strip detector, X-ray astronomy detectors, X-ray imaging.

Published
2006

70. Development of a Monte Carlo simulator for the Astro-E2 hard X-ray detector (HXD-II)

Author

Terada, Yukikatsu, Watanabe, Shin, Ohno, Masanori, Suzuki, Masaya, Itoh, Takeshi, Takahashi, Isao, Sato, Goro, Murashima, Mio, Kawano, Naomi, Uchiyama, Yasunobu, Kubo, Shin, Takahashi, Tadayuki, Tashiro, Makoto, Kokubun, Motohide, Makishima, Kazuo, Kamae, Tsuneyoshi, Murakami, Toshio, Nomachi, Masaharu, Fukazawa, Yasushi, Yamaoka, Kazutaka, Nakazawa, Kazuhiro, and Yonetoku, Daisuke

Subjects
Gamma rays -- Research, Artificial satellites -- Research, Detectors -- Research, Monte Carlo method -- Research, Business, Electronics, Electronics and electrical industries
Abstract

The Hard X-ray Detector (HXD-II) is one of the scientific payloads on board the fifth Japanese cosmic X-ray satellite Astro-E2, scheduled for launch in 2005. The HXD-II is designed to cover a wide energy range of 10-600 keV with a high sensitivity of about [10.sup.-5] cnt/s/[cm.sup.2]/keV. In order to derive the energy response of the sensor and to estimate the background, a Monte Carlo simulator based on the Geant4 toolkit is currently being developed. This paper describes the design concept of the HXD-II software package, including the analysis tools and the Monte Carlo simulator, and its verification through a comparison with actual data taken by pre-flight radio-isotope irradiation experiments, together with calculated outputs that can demonstrate the in-orbit performance of the HXD-II. Index Terms--Astronomical satellites, gamma-ray spectroscopy detectors, Monte Carlo, simulation.

Published
2005

73. Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction

Author

Hayashidani, Shunji, Tsutsui, Hiroyuki, Ikeuchi, Masaki, Shiomi, Tetsuya, Matsusaka, Hidenori, Kubota, Toru, Imanaka-Yoshida, Kyoko, Itoh, Takeshi, and Takeshita, Akira

Subjects
Heart failure -- Physiological aspects, Coronary arteries -- Physiological aspects, Biological sciences
Abstract

Matrix metalloproteinase-2 (MMP-2) is prominently overexpressed both after myocardial infarction (MI) and in heart failure. However, its pathophysiological significance in these conditions is still unclear. We thus examined the effects of targeted deletion of MMP-2 on post-MI left ventricular (LV) remodeling and failure. Anterior MI was produced in 10- to 12-wk-old male MMP-2 knock-out (KO) and sibling wild-type (WT) mice by ligating the left coronary artery. By day 28, MI resulted in a significant increase in mortality in association with LV cavity dilatation and dysfunction. The MMP-2 KO mice had a significantly better survival rate than WT mice (56% vs. 85%, P < 0.05), despite a comparable infarct size (50 [+ or -] 3% vs. 51 [+ or -] 3%, P = not significant), heart rate, and arterial blood pressure. The KO mice had a significantly lower incidence of LV rupture (10% vs. 39%, P < 0.05), which occurred within 7 days of MI. The KO mice exerted less LV cavity dilatation and improved fractional shortening after MI by echocardiography. The LV zymographic MMP-2 level significantly increased in WT mice after coronary artery ligation; however, this was completely prevented in KO mice. In contrast, the increase in the LV zymographic MMP-9 level after MI was similar between KO and WT mice. MMP-2 activation is therefore considered to contribute to an early cardiac rupture as well as late LV remodeling after MI. The inhibition of MMP-2 activation may therefore be a potentially useful therapeutic strategy to manage post-MI hearts. matrix metalloproteinase; cardiac rupture; heart failure; myocyte; extracellular matrix; mouse

Published
2003

79. Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy

Author

Wielockx, Ben, Lannoy, Katrien, Shapiro, Steven D., Itoh, Takeshi, Itohara, Shigeyoshi, Vandekerckhove, Joel, and Libert, Claude

Abstract

Acute and fulminant liver failure induced by viral hepatitis, alcohol or other hepatotoxic drugs, are associated with tumor necrosis factor (TNF) production. In a mouse model of lethal hepatitis induced by TNF, apoptosis and necrosis of hepatocytes, but also lethality, hypothermia and influx of leukocytes into the liver, are prevented by a broad-spectrum matrix metalloproteinase (MMP) inhibitor, BB-94. Mice deficient in MMP-2, MMP-3 or MMP-9 had lower levels of apoptosis and necrosis of hepatocytes, and better survival. We found induction of MMP-9 activity and fibronectin degradation. Our findings suggest that several MMPs play a critical role in acute, fulminant hepatitis by degrading the extracellular matrix and allowing massive leukocyte influx in the liver. BB-94 also prevented lethality in TNF/interferon-[gamma] therapy in tumor-bearing mice. A broad-spectrum MMP inhibitor may be potentially useful for the treatment of patients with acute and perhaps chronic liver failure, and in cancer therapies using inflammatory cytokines., Author(s): Ben Wielockx [1]; Katrien Lannoy [1]; Steven D. Shapiro [2]; Takeshi Itoh [3]; Shigeyoshi Itohara [4]; Joel Vandekerckhove [5]; Claude Libert (corresponding author) [1] The abrupt or chronic loss [...]

Published
2001
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92. The Rice Annotation Project Database (RAP-DB): 2008 update*

Author

Tanaka, Tsuyoshi, Antonio, Baltazar A., Kikuchi, Shoshi, Matsumoto, Takashi, Nagamura, Yoshiaki, Numa, Hisataka, Sakai, Hiroaki, Wu, Jianzhong, Itoh, Takeshi, Sasaki, Takuji, Aono, Ryo, Fujii, Yasuyuki, Habara, Takuya, Harada, Erimi, Kanno, Masako, Kawahara, Yoshihiro, Kawashima, Hiroaki, Kubooka, Hiromi, Matsuya, Akihiro, Nakaoka, Hajime, Saichi, Naomi, Sanbonmatsu, Ryoko, Sato, Yoshiharu, Shinso, Yuji, Suzuki, Mami, Takeda, Jun-ichi, Tanino, Motohiko, Todokoro, Fusano, Yamaguchi, Kaori, Yamamoto, Naoyuki, Yamasaki, Chisato, Imanishi, Tadashi, Okido, Toshihisa, Tada, Masahito, Ikeo, Kazuho, Tateno, Yoshio, Gojobori, Takashi, Lin, Yao-Cheng, Wei, Fu-Jin, Hsing, Yue-ie, Zhao, Qiang, Han, Bin, Kramer, Melissa R., McCombie, Richard W., Lonsdale, David, O’Donovan, Claire C., Whitfield, Eleanor J., Apweiler, Rolf, Koyanagi, Kanako O., Khurana, Jitendra P., Raghuvanshi, Saurabh, Singh, Nagendra K., Tyagi, Akhilesh K., Haberer, Georg, Fujisawa, Masaki, Hosokawa, Satomi, Ito, Yukiyo, Ikawa, Hiroshi, Shibata, Michie, Yamamoto, Mayu, Bruskiewich, Richard M., Hoen, Douglas R., Bureau, Thomas E., Namiki, Nobukazu, Ohyanagi, Hajime, Sakai, Yasumichi, Nobushima, Satoshi, Sakata, Katsumi, Barrero, Roberto A., Sato, Yutaka, Souvorov, Alexandre, Smith-White, Brian, Tatusova, Tatiana, An, Suyoung, An, Gynheung, OOta, Satoshi, Fuks, Galina, Messing, Joachim, Christie, Karen R., Lieberherr, Damien, Kim, HyeRan, Zuccolo, Andrea, Wing, Rod A., Nobuta, Kan, Green, Pamela J., Lu, Cheng, Meyers, Blake C., Chaparro, Cristian, Piegu, Benoit, Panaud, Olivier, and Echeverria, Manuel

Published
2008

93. The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts*

Author

Yamasaki, Chisato, Murakami, Katsuhiko, Fujii, Yasuyuki, Sato, Yoshiharu, Harada, Erimi, Takeda, Jun-ichi, Taniya, Takayuki, Sakate, Ryuichi, Kikugawa, Shingo, Shimada, Makoto, Tanino, Motohiko, Koyanagi, Kanako O., Barrero, Roberto A., Gough, Craig, Chun, Hong-Woo, Habara, Takuya, Hanaoka, Hideki, Hayakawa, Yosuke, Hilton, Phillip B., Kaneko, Yayoi, Kanno, Masako, Kawahara, Yoshihiro, Kawamura, Toshiyuki, Matsuya, Akihiro, Nagata, Naoki, Nishikata, Kensaku, Noda, Akiko Ogura, Nurimoto, Shin, Saichi, Naomi, Sakai, Hiroaki, Sanbonmatsu, Ryoko, Shiba, Rie, Suzuki, Mami, Takabayashi, Kazuhiko, Takahashi, Aiko, Tamura, Takuro, Tanaka, Masayuki, Tanaka, Susumu, Todokoro, Fusano, Yamaguchi, Kaori, Yamamoto, Naoyuki, Okido, Toshihisa, Mashima, Jun, Hashizume, Aki, Jin, Lihua, Lee, Kyung-Bum, Lin, Yi-Chueh, Nozaki, Asami, Sakai, Katsunaga, Tada, Masahito, Miyazaki, Satoru, Makino, Takashi, Ohyanagi, Hajime, Osato, Naoki, Tanaka, Nobuhiko, Suzuki, Yoshiyuki, Ikeo, Kazuho, Saitou, Naruya, Sugawara, Hideaki, OʼDonovan, Claire, Kulikova, Tamara, Whitfield, Eleanor, Halligan, Brian, Shimoyama, Mary, Twigger, Simon, Yura, Kei, Kimura, Kouichi, Yasuda, Tomohiro, Nishikawa, Tetsuo, Akiyama, Yutaka, Motono, Chie, Mukai, Yuri, Nagasaki, Hideki, Suwa, Makiko, Horton, Paul, Kikuno, Reiko, Ohara, Osamu, Lancet, Doron, Eveno, Eric, Graudens, Esther, Imbeaud, Sandrine, Anne Debily, Marie, Hayashizaki, Yoshihide, Amid, Clara, Han, Michael, Osanger, Andreas, Endo, Toshinori, Thomas, Michael A., Hirakawa, Mika, Makalowski, Wojciech, Nakao, Mitsuteru, Kim, Nam-Soon, Yoo, Hyang-Sook, De Souza, Sandro J., de Fatima Bonaldo, Maria, Niimura, Yoshihito, Kuryshev, Vladimir, Schupp, Ingo, Wiemann, Stefan, Bellgard, Matthew, Shionyu, Masafumi, Jia, Libin, Thierry-Mieg, Danielle, Thierry-Mieg, Jean, Wagner, Lukas, Zhang, Qinghua, Go, Mitiko, Minoshima, Shinsei, Ohtsubo, Masafumi, Hanada, Kousuke, Tonellato, Peter, Isogai, Takao, Zhang, Ji, Lenhard, Boris, Kim, Sangsoo, Chen, Zhu, Hinz, Ursula, Estreicher, Anne, Nakai, Kenta, Makalowska, Izabela, Hide, Winston, Tiffin, Nicola, Wilming, Laurens, Chakraborty, Ranajit, Soares, Marcelo Bento, Chiusano, Maria Luisa, Suzuki, Yutaka, Auffray, Charles, Yamaguchi-Kabata, Yumi, Itoh, Takeshi, Hishiki, Teruyoshi, Fukuchi, Satoshi, Nishikawa, Ken, Sugano, Sumio, Nomura, Nobuo, Tateno, Yoshio, Imanishi, Tadashi, and Gojobori, Takashi

Published
2008

94. Evola: Ortholog database of all human genes in H-InvDB with manual curation of phylogenetic trees

Author

Matsuya, Akihiro, Sakate, Ryuichi, Kawahara, Yoshihiro, Koyanagi, Kanako O., Sato, Yoshiharu, Fujii, Yasuyuki, Yamasaki, Chisato, Habara, Takuya, Nakaoka, Hajime, Todokoro, Fusano, Yamaguchi, Kaori, Endo, Toshinori, OOta, Satoshi, Makalowski, Wojciech, Ikeo, Kazuho, Suzuki, Yoshiyuki, Hanada, Kousuke, Hashimoto, Katsuyuki, Hirai, Momoki, Iwama, Hisakazu, Saitou, Naruya, Hiraki, Aiko T., Jin, Lihua, Kaneko, Yayoi, Kanno, Masako, Murakami, Katsuhiko, Noda, Akiko Ogura, Saichi, Naomi, Sanbonmatsu, Ryoko, Suzuki, Mami, Takeda, Jun-ichi, Tanaka, Masayuki, Gojobori, Takashi, Imanishi, Tadashi, and Itoh, Takeshi

Published
2008

97. Fuzzy sharing problem by possibility measure

Author

Itoh, Takeshi and Ishii, Hiroaki

Subjects
Algorithms -- Analysis, Fuzzy sets -- Analysis, Business, Business, general, Business, international
Abstract

A model was formulated to resolve a sharing problem with integer flow. The model presents the fuzzy goal to the problem being studied and regards the weight of every sink as fuzzy goal's possibility variables. It is a max-min type that optimizes the least possibility measure of the fuzzy goal involving sinks. An algorithm that takes advantage of the relationship between the flux and the possibility measure was utilized.

Published
1997

98. Abstracts of selected papers presented at the 34th annual meeting of the Japanese Society of Gastroenterology October 12–14, 1992, Utsunomiya, Japan

Author

Wisse, Eddie, Geerts, Bert, Hirose, Miyoko, Sato, Nobuhiro, Fukumura, Dai, Kurose, Iwao, Tanaka, Minoru, Ishibashi, Hiromi, Itoh, Yoshito, Okanoue, Takeshi, Naito, Makoto, Komatsu, Y., Shiratori, Y., Han, K. K., Hashimoto, N., Ikeda, Hitoshi, Wu, Catherine H., Matsuura, Tomokazu, Nagamori, Seishi, Tanaka, M., Tanikawa, K., Saibara, Toshiji, Onishi, Saburo, Balabaud, C., Nakano, Osamu, Sakamoto, Choitsu, Shimamoto, Chikao, Takao, Yujiro, Ota, Hiroshi, Katsuyama, Tsutomu, Hiraishi, Hideyuki, Terano, Akira, Naito, Yuji, Yoshikawa, Toshikazu, Kajita, Hidetoshi, Tatsuta, Hiroshi, Rokutan, Kazuhito, Aoike, Akira, Watanabe, Sumio, Kinoshita, Yoshikazu, Chiba, Tsutomu, Uehara, Akira, Kitamori, Shigeru, Maekawa, Soichiro, Shimoyama, Takashi, Otaka, Michiro, Masamune, Osamu, Mitsuyama, Keiichi, Tanikawa, Kyuichi, Kubota, Yoshiro, Watanabe, Toshiaki, Baba, Masaru, Hasegawa, Hiroshi, Aizawa, Yoshio, Zeniya, Mikio, Onji, Morikazu, Kumon, Izumi, Hasegawa, Itaru, Tsutsui, Hiroko, Miyakawa, Hiroshi, Kako, Makoto, Yamazaki, Masayo, Sugiyama, Yuichi, Ishii, Koji, Wolkoff, Allan, Narita, Tohru, Takikawa, Hajime, Kitamura, Tsuneo, Hayakawa, Tomihiro, Hoshino, Makoto, Harada, Masaru, Suzuki, Hiroshi, Adachi, Yukihiko, Kobayashi, Hiroaki, Yoshida, H., Harada, T., Sai, Jinkan, Ariyama, Jo, Yamaguchi, Taketo, Saisho, Hiromitsu, Hirooka, Yoshiki, Naitoh, Yasuo, Kamei, Akira, Ohashi, Kazuhiko, Obara, Takeshi, Maguchi, Hiroyuki, Yonezawa, Suguru, Osak, Masahiko, Kamei, Katsuhiko, Funabiki, Takahiko, Nagai, Hideo, Kasahara, Kogoro, Miyakawa, Shuichi, Horiguchi, Yuji, Sugiyama, Masanori, Atomi, Yutaka, Ehata, T., Omata, M., Nakamura, Tetsuo, Yamauchi, Katsumi, Katayama, Kazuhiro, Fusamoto, Hideyuki, Shiomi, Susumu, Kuroki, Tetsuo, Arase, Yasuji, Kumada, Hiromitsu, Murazumi, Yukari, Sekiya, Chihiro, Hige, Shuhei, Saga, Akiyoshi, Adachi, Hiroshi, Kaneko, Shuichi, Nakajima, Hisato, Toda, Gotaro, Takahashi, Shin’ichi, Itoh, Takeshi, Moriyama, Takashi, Imawari, Michio, Takeyama, Yoshifumi, Saitoh, Yoichi, Inui, Akio, Kasuga, Masato, Tokita, Kazuhiko, Tsuchihashi, Yasunari, Hasumura, Satoshi, Tarao, Kazuo, Shimizu, Akio, Kohda, Hironobu, Inoue, Kazuhiko, Haruma, Ken, Chonan, Akimichi, Mochizuki, Fukuji, Takemoto, Norishige, Baba, Yasumasa, Mizushima, Takaaki, Kimura, Ikuro, Azuma, Munenori, Shida, Shigemitu, Shimodaira, Masaya, Tsukamoto, Yoshihisa, Nagawa, Hirokazu, Sawada, Toshio, Katsumata, Tomoe, Mieno, Hiroyoshi, Hideshima, Amane, Suda, Yasuo, Nakamura, Tsuneya, Hayashi, Kayoko, Sekiyama, Tatsuya, Aramaki, Takumi, Kanazawa, Hidenori, Watari, Atsushi, Iwao, Tadashi, Toyonaga, Atsushi, Mizumoto, Hideaki, Matsutani, Shoichi, Kanagawa, Hiroshi, Mima, Satoaki, Moriishi, Shingo, Sumida, Nobuyuki, Kitano, S., Sugimachi, K., Obara, Katsutoshi, Kasukawa, Reiji, Ohashi, Kaoru, Beppu, Tomoe, Harada, Akio, Takagi, Hiroshi, Nishioka, Akihiko, Ashida, Hiroshi, Okushiba, Shunichi, Katoh, Hiroyuki, Ohkubo, Hitoshi, Arakawa, Yasuyuki, Kobayashi, Hideo, Seki, Masatake, Ohsuki, Masao, Maeda, Kenji, Hasebe, Tetsunori, Harasawa, Shigeru, Tamura, Koichiro, Ohshita, Masaru, Matsuike, Tsuneo, Suzuki, Yasumoto, Obata, Shinichiro, Kimura, Keishi, Harada, H., and Fukushima, T.

Published
1993
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100. Tailing of thermal inactivation curve of Aspergillus niger spores

Author

Fujikawa, Hiroshi and Itoh, Takeshi

Subjects
Spores (Bacteria) -- Research, Microorganisms -- Effect of temperature on, Biological sciences
Abstract

The thermal sensitivity of Aspergillus niger 326 was investigated to examine tailing in nonlinear thermal inactivation of the fungal spores. The cells were inactivated at constant temperatures around 60 degrees Centigrade. The thermal inactivation curve consisted of a shoulder, an accelerated decline and a tail. In a thermotolerant-subpopulation model, it was shown that the number of cells inactivated increased with increasing temperature. The rate of inactivation was influenced by cell concentration.

Published
1996

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