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Skin ageing is a progressive, but modifiable, multi-factorial disorder that involves all the skin’s tissues. Due to its wide range of physiological and psychosocial complications, skin ageing requires rigorous clinical attention. In this review, we aim to encourage clinicians to consider skin ageing as a disorder and suggest a novel, dual approach to its clinical treatment. Topical retinoids and per-oral proteoglycans are promising, non-invasive, therapeutic modalities. To overcome the low bioavailability of conventional free retinoids, Nourella® cream with Retilex-A® (Pharma Medico, Aarhus, Denmark) was developed using a proprietary nano-encapsulation technology. The nano-encapsulation is a sophisticated ‘permeation/penetration enhancer’ that optimises topical drug delivery by increasing the surface availability and net absorption ratio. Treatment adherence is also improved by minimising skin irritation. Interventional evidence suggests the greater efficacy of Retilex-A® in improving skin thickness and elasticity compared with conventional free forms. It is also reported that the rejuvenating efficacy of Retilex-A® and tretinoin are comparable. Another skin anti-ageing approach is proteoglycan replacement therapy (PRT) with Vercilex®. Vercilex® in Nourella® tablet form has the potential to ameliorate proteoglycan dysmetabolism in aged skin by activating skin cells and improving collagen/elastin turnover. Replicated clinical trials evidenced that PRT can significantly enhance the density, elasticity and thickness of both intrinsically aged and photoaged skin. Evidently, Vercilex® and Retilex-A® share a range of bioactivities that underlie their synergistic activity, as observed in a clinical trial. Dual therapy with Nourella® tablets and cream produced greater effects on skin characteristics than monotherapy with each of the two treatments. In conclusion, Nourella® cream and tablets are safe and effective treatments for skin ageing; however, combining the two in a ‘dual skin rejuvenation system’ significantly improves treatment outcomes.

Esta investigación cualitativa exploratoria pretende examinar la experiencia de la fibromialgia en el ámbito laboral y cómo la misma incide en el desempeño de las personas. Utilizamos el Modelo de Demandas y Recursos Laborales para entender cómo los recursos (laborales y personales) y las demandas afectan la efectividad en el trabajo de las personas con fibromialgia. Siete pacientes con fibromialgia residentes en Puerto Rico participaron en entrevistas semiestructuradas. Los resultados apuntan que la fibromialgia tiene un efecto negativo en el desempeño de tareas, principalmente si estas requieren de esfuerzo físico o continuidad en una misma postura por largos periodos. Además, el ambiente laboral incide en la sintomatología y está a su vez en el desempeño de las funciones. Por último, se presentan una serie de recomendaciones enmarcadas en la flexibilidad, recursos personales y la educación, las cuales buscan minimizar los efectos que tiene la fibromialgia en el trabajo.

Young people find it difficult to access to the labor market, particularly in countries like Spain with a dramatically high rate of unemployment. A further problem is that this labor market is not gender-neutral. This has been demonstrated repeatedly in the literature, with women typically being at a disadvantage. This highlights the need to study issues related to employability from a gender perspective, beyond including sex as a mere control variable. This analysis is relevant given the gender biases in organizations and in society in general that hinder the advancement of gender equality in organizations. Accordingly, our aim is to study both sex (male vs. female) and four profiles of gender identity based on dimensions of masculinity and femininity (i.e., feminine, masculine, undifferentiated, and androgynous) in relation to perceived employability in an exploratory way in two samples of employed (N = 181) and unemployed (N = 246) Spanish youngsters (i.e., below 30). The results show different patterns for employed and unemployed youngsters regarding sex, gender identity and their interaction in relation to perceptions of being employable. Concerning sex, women seem more confident about their employment chances when unemployed. In contrast, men feel more confident about their employment chances within their organization than women when employed. Concerning gender identity, the androgynous gender profile in the employed sample (in both men and women) scored highest on perceived employability. Results of the sex–gender identity interaction show that being feminine associates with the highest level of perceived employability for an unemployed man and the lowest for an unemployed woman. Moreover, both unemployed men and women androgynous score the highest in perceiving employability (except feminine men). Our findings highlight that sex and gender identity do play a role in shaping employability perceptions of young men and women in different labor contexts (employment and unemployment). This reinforces the need of changes against discrimination at work and in job search from a feminist approach to arrive at a more equal society.

Sánchez-Osorio, I y Moya, A. (2017): “‘Bosque especial’: intervención educativa en educación medioambiental para escolares con discapacidad visual”. Revista Española de Discapacidad, 5 (2): 195-210.

We have cloned, overexpressed, purified, and characterized a 2-ketogluconate kinase (2-dehydrogluconokinase, EC 2.7.1.13) from Cupriavidus necator (Ralstonia eutropha) H16. Exploration of its substrate specificity revealed that three ketoacids (2-keto-3-deoxy-d-gluconate, 2-keto-d-gulonate, and 2-keto-3-deoxy-d-gulonate) with structures close to the natural substrate (2-keto-d-gluconate) were successfully phosphorylated at an efficiency lower than or comparable to 2-ketogluconate, as depicted by the measured kinetic constant values. Eleven aldo and keto monosaccharides of different chain lengths and stereochemistries were also assayed but not found to be substrates. 2-ketogluconate-6-phosphate was synthesized at a preparative scale and was fully characterized for the first time.

Prinobius myardi Mulsant is a wood borer implicated in the decline of Mediterranean oaks, especially Quercus suber L. and Quercus ilex L. Plant volatiles play an important role in plant-insect interactions, and electroantennography (EAG) is an effective tool for exploring the electrophysiological activity of host plant volatiles on insects. To improve our understanding of the olfactory sensitivity of P. myardi, we recorded EAG responses to 20 tree volatiles, and analyzed the dose-dependent response to five doses (10–4:1 to 1:1 v/v) of the three most EAG-active compounds. Antennae of P. myardi responded to 13 chemicals, mainly monoterpenes and green leaf volatiles, with the strongest EAG responses being observed with β-pinene, (+)-α-pinene and 1,8-cineole. Dose–response profiles showed positive dose-dependent responses for all three compounds. Our results suggest a broad sensitivity of P. myardi to common tree volatiles, particularly some host-related compounds and volatiles associated with wounded trees; the olfactory recognition of ratios of these compounds could play a role in host selection by P. myardi.