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58. Effects of Elobixibat on Constipation and Lipid Metabolism in Patients With Moderate to End-Stage Chronic Kidney Disease

Author

Matsuyama, Momoko, primary, Hirai, Keiji, additional, Nonaka, Hiroaki, additional, Ueda, Moeka, additional, Morino, Junki, additional, Kaneko, Shohei, additional, Minato, Saori, additional, Mutsuyoshi, Yuko, additional, Yanai, Katsunori, additional, Ishii, Hiroki, additional, Kitano, Taisuke, additional, Aomatsu, Akinori, additional, Miyazawa, Haruhisa, additional, Ito, Kiyonori, additional, Ueda, Yuichiro, additional, Ookawara, Susumu, additional, and Morishita, Yoshiyuki, additional

Published
2022
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59. A Study on Surgical Outcomes of Pars Flaccida Cholesteatoma

Author

Hayashi, Akira, primary, Tanaka, Shota, additional, Endo, Shuichiro, additional, Takahashi, Mari, additional, Horiuchi, Kiwako, additional, Shimamura, Ayumi, additional, Ishii, Hiroki, additional, Matsuoka, Tomokazu, additional, Sakurai, Daiju, additional, and Masuyama, Keisuke, additional

Published
2022
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60. Risk Factors and Utility of Intraoperative Arteriovenous Fistula Blood Flow Level as a Surrogate Marker of Arteriovenous Fistula Failure in Patients with End-stage Renal Disease

Author

Shindo, Mitsutoshi, additional, Morino, Junki, additional, Minato, Saori, additional, Kaneko, Shohei, additional, Mutsuyoshi, Yuko, additional, Yanai, Katsunori, additional, Ishii, Hiroki, additional, Matsuyama, Momoko, additional, Kitano, Taisuke, additional, Miyazawa, Haruhisa, additional, Ito, Kiyonori, additional, Shimoyama, Hirofumi, additional, Ueda, Yuichiro, additional, Hirai, Keiji, additional, Hoshino, Taro, additional, Ookawara, Susumu, additional, and Morishita, Yoshiyuki, additional

Published
2022
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62. A case report of PR-3-ANCA-positive glomerulonephritis with histological features of GPA associated with infectious endocarditis

Author

Hirata, Momoko, primary, Miyazawa, Haruhisa, additional, Morino, Junki, additional, Kaneko, Shohei, additional, Minato, Saori, additional, Katsunori, Yanai, additional, Ishii, Hiroki, additional, Kitano, Taisuke, additional, Ito, Kiyonori, additional, Hirai, Keiji, additional, Oda, Takashi, additional, Shimizu, Akira, additional, Ueda, Yoshihiko, additional, and Morishita, Yoshiyuki, additional

Published
2021
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63. No Significant Changes of Glycemic Control and Renal Function in Patients with Advanced-Stage Diabetic Kidney Disease by Switching from Linagliptin to Teneligliptin

Author

Hirai, Keiji, primary, Nonaka, Hiroaki, additional, Ueda, Moeka, additional, Morino, Junki, additional, Kaneko, Shohei, additional, Minato, Saori, additional, Mutsuyoshi, Yuko, additional, Yanai, Katsunori, additional, Ishii, Hiroki, additional, Matsuyama, Momoko, additional, Kitano, Taisuke, additional, Aomatsu, Akinori, additional, Miyazawa, Haruhisa, additional, Ito, Kiyonori, additional, Ueda, Yuichiro, additional, Ookawara, Susumu, additional, and Morishita, Yoshiyuki, additional

Published
2021
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64. Idiopathic hypereosinophilic syndrome in hemodialysis patients

Author

Mutsuyoshi, Yuko, Hirai, Keiji, Morino, Junki, Kaneko, Shohei, Minato, Saori, Yanai, Katsunori, Ishii, Hiroki, Matsuyama, Momoko, Kitano, Taisuke, Aomatsu, Akinori, Miyazawa, Haruhisa, Ito, Kiyonori, Ueda, Yuichiro, Ookawara, Susumu, and Morishita, Yoshiyuki

Subjects
Aged, 80 and over, Male, hemodialysis, Nephrosclerosis, Dose-Response Relationship, Drug, Prednisolone, corticosteroid therapy, Administration, Oral, Middle Aged, Nephrectomy, Diagnosis, Differential, Eosinophils, Leukocyte Count, Treatment Outcome, Renal Dialysis, idiopathic hypereosinophilic syndrome, Hypereosinophilic Syndrome, Humans, Diabetic Nephropathies, Clinical Case Report, Renal Insufficiency, Glucocorticoids, Research Article
Abstract

Rationale: Herein, we report 3 hemodialysis patients with idiopathic hypereosinophilic syndrome who were successfully treated using corticosteroid therapy. Patient concerns: Case 1 was a 63-year-old man who was undergoing hemodialysis because of bilateral nephrectomy and developed hypereosinophilia with digestive symptoms, myocardial injury, and intradialytic hypotension. Case 2 was an 83-year-old man who was undergoing hemodialysis because of nephrosclerosis and developed hypereosinophilia with pruritus, myocardial injury, and intradialytic hypotension. Case 3 was a 59-year-old man who was undergoing hemodialysis because of diabetic nephropathy and developed hypereosinophilia with pruritus, myocardial injury, and intradialytic hypotension. Diagnoses: All 3 patients presented with hypereosinophilia (eosinophil count ≥1500 /μL for more than 1 month) and multiple-organ involvement (intradialytic hypotension, cardiac injury, digestive symptoms, and allergic dermatitis). A specific cause for the hypereosinophilia was not identified by systemic computed tomography, electrocardiography, echocardiography, bone marrow examination, or blood tests. Furthermore, Case 2 and 3 had not recently started taking any new drugs and drug-induced lymphocyte stimulation tests were negative in Case 1. Therefore, they were diagnosed with idiopathic hypereosinophilic syndrome. Interventions: All 3 patients received corticosteroid therapy with prednisolone at a dose of 40 mg/d, 30 mg/d, and 60 mg/d in Case 1, 2, and 3, respectively. Outcomes: Their digestive symptoms, pruritus, intradialytic hypotension, and serum troponin I concentrations were immediately improved alongside reductions in their eosinophil counts. Lessons: There have been few case reports of idiopathic hypereosinophilic syndrome in patients undergoing hemodialysis. We believe that recording of the clinical findings and treatments of such patients is mandatory to establish the optimal management of idiopathic hypereosinophilic syndrome.

Published
2021

66. Effects of Roxadustat on the Anemia and Iron Metabolism of Patients Undergoing Peritoneal Dialysis

Author

Hirai, Keiji, primary, Nonaka, Hiroaki, additional, Ueda, Moeka, additional, Morino, Junki, additional, Kaneko, Shohei, additional, Minato, Saori, additional, Mutsuyoshi, Yuko, additional, Yanai, Katsunori, additional, Ishii, Hiroki, additional, Matsuyama, Momoko, additional, Kitano, Taisuke, additional, Aomatsu, Akinori, additional, Miyazawa, Haruhisa, additional, Ito, Kiyonori, additional, Ueda, Yuichiro, additional, Ookawara, Susumu, additional, and Morishita, Yoshiyuki, additional

Published
2021
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67. Clinical factors affecting cerebral oxygenation in patients undergoing peritoneal dialysis

Author

Kitano, Taisuke, primary, Ito, Kiyonori, additional, Ookawara, Susumu, additional, Hoshino, Taro, additional, Hayasaka, Hideyuki, additional, Kofuji, Masaya, additional, Uchida, Takayuki, additional, Morino, Junki, additional, Minato, Saori, additional, Kaneko, Shohei, additional, Yanai, Katsunori, additional, Mutsuyoshi, Yuko, additional, Ishii, Hiroki, additional, Matsuyama-Hirata, Momoko, additional, Shindo, Mitsutoshi, additional, Miyazawa, Haruhisa, additional, Ueda, Yuichiro, additional, Hirai, Keiji, additional, and Morishita, Yoshiyuki, additional

Published
2021
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68. Char burnout characteristics of various Vietnamese woody biomass: Effect of lean and rich oxygen concentration on char conversion

Author

Le, Duc Dung, Pham, Anh Tuan, Nguyen, Huu Linh, Nam Nguyen, Hong, Ohno, Emi, Ishii, Hiroki, and Van De Steene, Laurent

Subjects
complex mixtures
Abstract

The influence of oxygen concentration on the char burnout characteristics of the coniferous tree (beefwood) and broadleaf tree (beech), ưhich are abundantly available in Vietnam under-reacting temperature of 800 oC, and 1000 °C was investigated using Macro TG. The obtained results showed that in rich O2 concentration, the particle size has little effect on char oxidation. However, the carbon conversion rate and the whole time of conversion decreases with an increase in particle size. There were some excepted cases contracting to this trend, mainly due to the difference in char samples' morphological structure at different sizes and operating temperatures in lean O2 concentration. The characteristics of biomass strongly affect the char oxidation rate. In all experiments, the conversion rate of char oxidation of the inside part of beefwood is higher than the bark's conversion rate. The oxidation rate of beech bark is higher than the one of the inside parts of the beech. There is no significant difference in char oxidation rate between the inside part of the beefwood and beech wood bark. However, all kinds of biomass in this study have a faster rate of oxidation than coal.

Published
2021

69. No Significant Changes of Glycemic Control and Renal Function in Patients with Advanced-Stage Diabetic Kidney Disease by Switching from Linagliptin to Teneligliptin

Author

Hirai,Keiji, Nonaka,Hiroaki, Ueda,Moeka, Morino,Junki, Kaneko,Shohei, Minato,Saori, Mutsuyoshi,Yuko, Yanai,Katsunori, Ishii,Hiroki, Matsuyama,Momoko, Kitano,Taisuke, Aomatsu,Akinori, Miyazawa,Haruhisa, Ito,Kiyonori, Ueda,Yuichiro, Ookawara,Susumu, Morishita,Yoshiyuki, Hirai,Keiji, Nonaka,Hiroaki, Ueda,Moeka, Morino,Junki, Kaneko,Shohei, Minato,Saori, Mutsuyoshi,Yuko, Yanai,Katsunori, Ishii,Hiroki, Matsuyama,Momoko, Kitano,Taisuke, Aomatsu,Akinori, Miyazawa,Haruhisa, Ito,Kiyonori, Ueda,Yuichiro, Ookawara,Susumu, and Morishita,Yoshiyuki

Abstract

Keiji Hirai, Hiroaki Nonaka, Moeka Ueda, Junki Morino, Shohei Kaneko, Saori Minato, Yuko Mutsuyoshi, Katsunori Yanai, Hiroki Ishii, Momoko Matsuyama, Taisuke Kitano, Akinori Aomatsu, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Susumu Ookawara, Yoshiyuki Morishita Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, JapanCorrespondence: Keiji HiraiDivision of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, JapanTel +81-48-647-2111Fax +81-48-647-6831Email keijihirai@kfy.biglobe.ne.jpPurpose: We compared the efficacy of teneligliptin versus linagliptin for glycemic control and renoprotection in patients with advanced-stage diabetic kidney disease.Patients and Methods: Changes in the glycated hemoglobin (HbA1c), fasting blood glucose concentration, urine albumin-to-creatinine ratio (UACR), and estimated glomerular filtration rate (eGFR) during a 12-month period were retrospectively analyzed after switching from linagliptin to teneligliptin in 13 patients with advanced-stage diabetic kidney disease (teneligliptin group). Thirteen propensity score-matched patients who were treated with linagliptin alone served as controls (linagliptin group).Results: The HbA1c, fasting blood glucose concentration, and UACR did not change during the 12-month study period in either group. The annual change rate in the eGFR did not differ between before and after baseline in either group.Conclusion: Switching from linagliptin to teneligliptin may not improve glycemic control, reduce urinary protein excretion, or ameliorate the rate of renal function decline in patients with advanced-stage diabetic kidney disease. These results suggest that teneligliptin may not be more advantageous for glycemic control and renoprotection compared with linagliptin in patients with advanced-stage diabetic kidney disease.Keywords: chronic kidney disease, diabetic kidney dise

Published
2021

74. Factors Associated with the Change in Carotid Maximum Intima-Media Thickness in Patients with Moderate-to-Advanced Stage Chronic Kidney Disease

Author

Hirai, Keiji, Morino, Junki, Minato, Saori, Kaneko, Shohei, Yanai, Katsunori, Mutsuyoshi, Yuko, Ishii, Hiroki, Matsuyama, Momoko, Kitano, Taisuke, Aomatsu, Akinori, Miyazawa, Haruhisa, Ito, Kiyonori, Ueda, Yuichiro, Ookawara, Susumu, and Morishita, Yoshiyuki

Subjects
carotid maximum intima-media thickness, cardiovascular system, cardiovascular diseases, atherosclerosis, Targets and Therapy [Diabetes, Metabolic Syndrome and Obesity], chronic kidney disease, Original Research
Abstract

Keiji Hirai, Junki Morino, Saori Minato, Shohei Kaneko, Katsunori Yanai, Yuko Mutsuyoshi, Hiroki Ishii, Momoko Matsuyama, Taisuke Kitano, Akinori Aomatsu, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Susumu Ookawara, Yoshiyuki Morishita Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, JapanCorrespondence: Keiji HiraiDivision of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama-shi, Saitama-ken 330-8503, JapanTel +81-48-647-2111Fax +81-48-647-6831Email keijihirai@kfy.biglobe.ne.jpPurpose: The objective of this study was to determine factors associated with the change in carotid maximum intima-media thickness (IMT), an established surrogate marker of atherosclerosis, in moderate-to-advanced stage chronic kidney disease (CKD) patients.Methods: In total, 130 moderate-to-advanced stage CKD patients (mean age: 67.6 ± 11.0 years old; 91 men and 39 women) were included in this retrospective, single-center, observational study. Relationships between the change in carotid maximum IMT and clinical and laboratory data were analyzed by using multivariate linear regression analyses.Results: Mean observation period was 2.9 ± 1.6 years. Mean carotid maximum IMT at baseline was 2.2 ± 1.0 mm, and the annual change in carotid maximum IMT was 0.06 ± 0.22 mm/year. Low-density lipoprotein (LDL)-cholesterol (β = 0.173, p < 0.05) and annual change in triglyceride (β = 0.175, p < 0.05) independently correlated with the annual change in carotid maximum IMT.Conclusion: Increases in LDL-cholesterol and triglyceride were associated with the rate of progression of carotid maximum IMT in moderate-to-advanced stage CKD patients.Keywords: atherosclerosis, carotid maximum intima-media thickness, chronic kidney disease

Published
2020

75. Factors Associated with Uremic Pruritus in Patients Undergoing Peritoneal Dialysis

Author

Minato, Saori, Hirai, Keiji, Morino, Junki, Kaneko, Shohei, Yanai, Katsunori, Mutsuyoshi, Yuko, Ishii, Hiroki, Matsuyama, Momoko, Kitano, Taisuke, Shindo, Mitsutoshi, Aomatsu, Akinori, Miyazawa, Haruhisa, Ito, Kiyonori, Ueda, Yuichiro, Hoshino, Taro, Ookawara, Susumu, and Morishita, Yoshiyuki

Subjects
peritoneal dialysis, International Journal of Nephrology and Renovascular Disease, uremic pruritus, Original Research
Abstract

Saori Minato, Keiji Hirai, Junki Morino, Shohei Kaneko, Katsunori Yanai, Yuko Mutsuyoshi, Hiroki Ishii, Momoko Matsuyama, Taisuke Kitano, Mitsutoshi Shindo, Akinori Aomatsu, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Taro Hoshino, Susumu Ookawara, Yoshiyuki Morishita Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, JapanCorrespondence: Keiji HiraiDivision of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama, Saitama 330-8503, JapanTel +81-48-647-2111Fax +81-48-647-6831Email keijihirai@kfy.biglobe.ne.jpAim: The aim of this study was to investigate different intensities of uremic pruritus in the daytime and nighttime, as well as contributing factors, in patients undergoing peritoneal dialysis (PD).Methods: A total of 46 patients (31 males, 15 females) with a mean age of 59.4± 14.7 years and mean PD vintage of 29.2± 25.2 months were enrolled in this single-center, prospective, cross-sectional study. The intensity of uremic pruritus in the daytime and nighttime was assessed using a visual analog scale (VAS). The relationships between intensity and various clinical and laboratory parameters were analyzed using multiple linear regression analyses.Results: The most common site of uremic pruritus was on the back (70%), followed by lower limbs (67%), chest and abdomen (59%), upper limbs (28%), and head and neck (22%). Mean VAS scores were higher in the nighttime compared with the daytime (4.5± 3.3 vs. 3.5± 2.7, P=0.02). Only male sex was correlated with higher uremic pruritus intensity in the daytime (standard coefficient [β]=0.310, P=0.036). PD vintage (β=0.415, P=0.004) and topical medicines, including moisturizer and topical corticosteroid use (β=0.345, P=0.019), were independently correlated with higher uremic pruritus intensity in the nighttime.Conclusion: Uremic pruritus intensity was greater in the nighttime than in the daytime in PD patients. Male sex was associated with higher uremic pruritus intensity in the daytime, whereas PD vintage and topical medicine use were associated with higher uremic pruritus intensity in the nighttime.Keywords: uremic pruritus, peritoneal dialysis &nbsp

Published
2020

76. Factors Associated with Uremic Pruritus in Patients Undergoing Peritoneal Dialysis

Author

Minato,Saori, Hirai,Keiji, Morino,Junki, Kaneko,Shohei, Yanai,Katsunori, Mutsuyoshi,Yuko, Ishii,Hiroki, Matsuyama,Momoko, Kitano,Taisuke, Shindo,Mitsutoshi, Aomatsu,Akinori, Miyazawa,Haruhisa, Ito,Kiyonori, Ueda,Yuichiro, Hoshino,Taro, Ookawara,Susumu, Morishita,Yoshiyuki, Minato,Saori, Hirai,Keiji, Morino,Junki, Kaneko,Shohei, Yanai,Katsunori, Mutsuyoshi,Yuko, Ishii,Hiroki, Matsuyama,Momoko, Kitano,Taisuke, Shindo,Mitsutoshi, Aomatsu,Akinori, Miyazawa,Haruhisa, Ito,Kiyonori, Ueda,Yuichiro, Hoshino,Taro, Ookawara,Susumu, and Morishita,Yoshiyuki

Abstract

Saori Minato, Keiji Hirai, Junki Morino, Shohei Kaneko, Katsunori Yanai, Yuko Mutsuyoshi, Hiroki Ishii, Momoko Matsuyama, Taisuke Kitano, Mitsutoshi Shindo, Akinori Aomatsu, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Taro Hoshino, Susumu Ookawara, Yoshiyuki Morishita Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, JapanCorrespondence: Keiji HiraiDivision of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama, Saitama 330-8503, JapanTel +81-48-647-2111Fax +81-48-647-6831Email keijihirai@kfy.biglobe.ne.jpAim: The aim of this study was to investigate different intensities of uremic pruritus in the daytime and nighttime, as well as contributing factors, in patients undergoing peritoneal dialysis (PD).Methods: A total of 46 patients (31 males, 15 females) with a mean age of 59.4± 14.7 years and mean PD vintage of 29.2± 25.2 months were enrolled in this single-center, prospective, cross-sectional study. The intensity of uremic pruritus in the daytime and nighttime was assessed using a visual analog scale (VAS). The relationships between intensity and various clinical and laboratory parameters were analyzed using multiple linear regression analyses.Results: The most common site of uremic pruritus was on the back (70%), followed by lower limbs (67%), chest and abdomen (59%), upper limbs (28%), and head and neck (22%). Mean VAS scores were higher in the nighttime compared with the daytime (4.5± 3.3 vs. 3.5± 2.7, P=0.02). Only male sex was correlated with higher uremic pruritus intensity in the daytime (standard coefficient [β]=0.310, P=0.036). PD vintage (β=0.415, P=0.004) and topical medicines, including moisturizer and topical corticosteroid use (β=0.345, P=0.019), were independently correlated with higher uremic pruritus intensity in th

Published
2020

77. Factors Associated with the Change in Carotid Maximum Intima-Media Thickness in Patients with Moderate-to-Advanced Stage Chronic Kidney Disease

Author

Hirai,Keiji, Morino,Junki, Minato,Saori, Kaneko,Shohei, Yanai,Katsunori, Mutsuyoshi,Yuko, Ishii,Hiroki, Matsuyama,Momoko, Kitano,Taisuke, Aomatsu,Akinori, Miyazawa,Haruhisa, Ito,Kiyonori, Ueda,Yuichiro, Ookawara,Susumu, Morishita,Yoshiyuki, Hirai,Keiji, Morino,Junki, Minato,Saori, Kaneko,Shohei, Yanai,Katsunori, Mutsuyoshi,Yuko, Ishii,Hiroki, Matsuyama,Momoko, Kitano,Taisuke, Aomatsu,Akinori, Miyazawa,Haruhisa, Ito,Kiyonori, Ueda,Yuichiro, Ookawara,Susumu, and Morishita,Yoshiyuki

Abstract

Keiji Hirai, Junki Morino, Saori Minato, Shohei Kaneko, Katsunori Yanai, Yuko Mutsuyoshi, Hiroki Ishii, Momoko Matsuyama, Taisuke Kitano, Akinori Aomatsu, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Susumu Ookawara, Yoshiyuki Morishita Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, JapanCorrespondence: Keiji HiraiDivision of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama-shi, Saitama-ken 330-8503, JapanTel +81-48-647-2111Fax +81-48-647-6831Email keijihirai@kfy.biglobe.ne.jpPurpose: The objective of this study was to determine factors associated with the change in carotid maximum intima-media thickness (IMT), an established surrogate marker of atherosclerosis, in moderate-to-advanced stage chronic kidney disease (CKD) patients.Methods: In total, 130 moderate-to-advanced stage CKD patients (mean age: 67.6 ± 11.0 years old; 91 men and 39 women) were included in this retrospective, single-center, observational study. Relationships between the change in carotid maximum IMT and clinical and laboratory data were analyzed by using multivariate linear regression analyses.Results: Mean observation period was 2.9 ± 1.6 years. Mean carotid maximum IMT at baseline was 2.2 ± 1.0 mm, and the annual change in carotid maximum IMT was 0.06 ± 0.22 mm/year. Low-density lipoprotein (LDL)-cholesterol (β = 0.173, p < 0.05) and annual change in triglyceride (β = 0.175, p < 0.05) independently correlated with the annual change in carotid maximum IMT.Conclusion: Increases in LDL-cholesterol and triglyceride were associated with the rate of progression of carotid maximum IMT in moderate-to-advanced stage CKD patients.Keywords: atherosclerosis, carotid maximum intima-media thickness, chronic kidney disease

Published
2020

78. The Efficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Patients with Advanced-Stage Diabetic Kidney Disease Taking Renin-Angiotensin System Blockers

Author

Hirai,Keiji, Morino,Junki, Minato,Saori, Kaneko,Shohei, Yanai,Katsunori, Mutsuyoshi,Yuko, Ishii,Hiroki, Matsuyama,Momoko, Kitano,Taisuke, Shindo,Mitsutoshi, Aomatsu,Akinori, Miyazawa,Haruhisa, Ito,Kiyonori, Ueda,Yuichiro, Ookawara,Susumu, Morishita,Yoshiyuki, Hirai,Keiji, Morino,Junki, Minato,Saori, Kaneko,Shohei, Yanai,Katsunori, Mutsuyoshi,Yuko, Ishii,Hiroki, Matsuyama,Momoko, Kitano,Taisuke, Shindo,Mitsutoshi, Aomatsu,Akinori, Miyazawa,Haruhisa, Ito,Kiyonori, Ueda,Yuichiro, Ookawara,Susumu, and Morishita,Yoshiyuki

Abstract

Keiji Hirai, Junki Morino, Saori Minato, Shohei Kaneko, Katsunori Yanai, Yuko Mutsuyoshi, Hiroki Ishii, Momoko Matsuyama, Taisuke Kitano, Mitsutoshi Shindo, Akinori Aomatsu, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Susumu Ookawara, Yoshiyuki Morishita Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, JapanCorrespondence: Keiji HiraiDivision of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-Cho, Omiya-Ku, Saitama City, Saitama 330-8503, JapanTel +81-48-647-2111Fax +81-48-647-6831Email keijihirai@kfy.biglobe.ne.jpIntroduction and Objectives: We investigated the efficacy and safety of sodium-glucose cotransporter-2 (SGLT-2) inhibitors as an add-on therapy in patients with advanced-stage diabetic kidney disease taking renin-angiotensin system (RAS) blockers.Materials and Methods: Changes in glycated hemoglobin (HbA1c), urine protein-to-creatinine ratio (UACR), body weight, systolic blood pressure, and annual change in estimated glomerular filtration rate (eGFR) were retrospectively analyzed in 20 patients after 12 months of SGLT-2 inhibitor administration (mean eGFR: 22.8 ± 9.7 mL/min/1.73 m2). All patients had advanced-stage diabetic kidney disease and were taking RAS blockers. Twenty patients matched with similar propensity scores who were not taking SGLT-2 inhibitors served as the control group.Results: The annual change in eGFR improved significantly from − 8.6 ± 12.5 mL/min/1.73 m2/year to − 2.6 ± 5.0 mL/min/1.73 m2/year after 12 months by SGLT-2 inhibitor administration (p < 0.05), but did not change in the control group. Other clinical parameters, such as HbA1c, UACR, body weight, blood pressure, serum lipids, and electrolytes did not change in either group. No adverse effects were observed by taking SGLT-2 inhibitors.Conclusion: Using SGLT-2 inhibitors as

Published
2020

82. Event-Related Psychological Distress Scale

Author

Seki, Ryota, primary, Hashimoto, Tasuku, additional, Tanaka, Mami, additional, Ishii, Hiroki, additional, Ogawa, Michi, additional, Sato, Aiko, additional, Kimura, Atsushi, additional, Shiina, Akihiro, additional, Nakazato, Michiko, additional, and Iyo, Masaomi, additional

Published
2021
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84. A Study on Tympanoplasty in Chronic Otitis Media

Author

Tanaka, Shota, primary, Hayashi, Akira, additional, Endo, Shuichiro, additional, Takahashi, Mari, additional, Horiuchi, Kiwako, additional, Shimamura, Ayumi, additional, Matsuoka, Tomokazu, additional, Ishii, Hiroki, additional, and Sakurai, Daiju, additional

Published
2021
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86. Relationship between serum total carbon dioxide concentration and bicarbonate concentration in patients undergoing hemodialysis

Author

Hirai, Keiji, primary, Ookawara, Susumu, additional, Morino, Junki, additional, Minato, Saori, additional, Kaneko, Shohei, additional, Yanai, Katsunori, additional, Ishii, Hiroki, additional, Matsuyama, Momoko, additional, Kitano, Taisuke, additional, Shindo, Mitsutoshi, additional, Miyazawa, Haruhisa, additional, Ito, Kiyonori, additional, Ueda, Yuichirou, additional, Watano, Tatsuro, additional, Fujino, Shinji, additional, Omoto, Kiyoka, additional, and Morishita, Yoshiyuki, additional

Published
2020
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90. Serum Zinc Concentration Correlates With Ferritin Concentration in Patients Undergoing Peritoneal Dialysis: A Cross-Sectional Study

Author

Kaneko, Shohei, primary, Morino, Junki, additional, Minato, Saori, additional, Yanai, Katsunori, additional, Mutsuyoshi, Yuko, additional, Ishii, Hiroki, additional, Matsuyama, Momoko, additional, Kitano, Taisuke, additional, Shindo, Mitsutoshi, additional, Aomatsu, Akinori, additional, Miyazawa, Haruhisa, additional, Ueda, Yuichiro, additional, Ito, Kiyonori, additional, Hirai, Keiji, additional, Ookawara, Susumu, additional, and Morishita, Yoshiyuki, additional

Published
2020
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93. MicroRNAs in Podocyte Injury in Diabetic Nephropathy

Author

Ishii, Hiroki, primary, Kaneko, Shohei, additional, Yanai, Katsunori, additional, Aomatsu, Akinori, additional, Hirai, Keiji, additional, Ookawara, Susumu, additional, Ishibashi, Kenichi, additional, and Morishita, Yoshiyuki, additional

Published
2020
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96. MicroRNAs in Sarcopenia: A Systematic Review

Author

Yanai, Katsunori, primary, Kaneko, Shohei, additional, Ishii, Hiroki, additional, Aomatsu, Akinori, additional, Ito, Kiyonori, additional, Hirai, Keiji, additional, Ookawara, Susumu, additional, Ishibashi, Kenichi, additional, and Morishita, Yoshiyuki, additional

Published
2020
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97. Induction of DNMT3B by PGE2 and IL6 at Distant Metastatic Sites Promotes Epigenetic Modification and Breast Cancer Colonization

Author

So, Jae Young, primary, Skrypek, Nicolas, additional, Yang, Howard H., additional, Merchant, Anand S., additional, Nelson, George W., additional, Chen, Wei-Dong, additional, Ishii, Hiroki, additional, Chen, Jennifer M., additional, Hu, Gangqing, additional, Achyut, Bhagelu R., additional, Yoon, Esther C., additional, Han, Liying, additional, Huang, Chuanshu, additional, Cam, Margaret C., additional, Zhao, Keji, additional, Lee, Maxwell P., additional, and Yang, Li, additional

Published
2020
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99. Cerebral oxygenation improvement is associated with hemoglobin increase after hemodialysis initiation

Author

Ito, Kiyonori, primary, Ookawara, Susumu, additional, Ueda, Yuichiro, additional, Miyazawa, Haruhisa, additional, Uchida, Takayuki, additional, Kofuji, Masaya, additional, Hayasaka, Hideyuki, additional, Minato, Saori, additional, Kaneko, Shohei, additional, Mutsuyoshi, Yuko, additional, Yanai, Katsunori, additional, Ishii, Hiroki, additional, Matsuyama, Momoko, additional, Kitano, Taisuke, additional, Shindo, Mitsutoshi, additional, Aomatsu, Akinori, additional, Hirai, Keiji, additional, Hoshino, Taro, additional, Tabei, Kaoru, additional, and Morishita, Yoshiyuki, additional

Published
2020
Full Text
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