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51. HLA-Matched Treg/Tcon Allogeneic Hematopoietic Cell Transplantation Is Safe and Ensures Remarkable Chronic GvHD/Leukemia Free Survival in High-Risk Leukemia Patients

Author

Pierini, Antonio, primary, Ruggeri, Loredana, additional, Saldi, Simonetta, additional, Tricarico, Sara, additional, Marzuttini, Francesca, additional, Viglione, Valerio, additional, Sembenico, Rebecca, additional, Zei, Tiziana, additional, Iacucci Ostini, Roberta, additional, Mancusi, Antonella, additional, Limongello, Roberto, additional, Minelli, Olivia, additional, Ingrosso, Gianluca, additional, Terenzi, Adelmo, additional, Martelli, Maria Paola, additional, Caniglia, Maurizio, additional, Mecucci, Cristina, additional, Velardi, Andrea, additional, Martelli, Massimo Fabrizio, additional, Aristei, Cynthia, additional, and Carotti, Alessandra, additional

Published
2022
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52. Salvage radiotherapy guided by functional imaging for macroscopic local recurrence following radical prostatectomy: A multicentric retrospective study.

Author

Benziane Ouaritini, Nicolas, primary, Zilli, Thomas, additional, Ingrosso, Gianluca, additional, Pasquier, David, additional, renard Penna, Raphaelle, additional, Ferrari, Victoria, additional, Achard, Verane, additional, Pasquier, Corentin, additional, Perennec, Tanguy, additional, Di Staso, Mario, additional, Mihoci, Inga, additional, Trippa, Fabio, additional, Francolini, Giulio, additional, Meyer, Emmanuel, additional, Schick, Ulrike, additional, Cosset, Jean Marc, additional, Martin, Etienne, additional, Supiot, Stephane, additional, Latorzeff, Igor, additional, and Sargos, Paul, additional

Published
2022
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53. Recommendations for radiation therapy in oligometastatic prostate cancer: An ESTRO-ACROP Delphi consensus

Author

Cirugía, radiología y medicina física, Kirurgia,erradiologia eta medikuntza fisikoa, Zilli, Thomas, Achard, Vérane, Dal Pra, Alan, Schmidt-Hegemann, Nina, Jereczek-Fossa, Barbara Alicja, Lancia, Andrea, Ingrosso, Gianluca, Alongi, Filippo, Aluwini, Shafak, Arcangeli, Stefano, Blanchard, Pierre, Conde Moreno, Antonio, Couñago, Felipe, Créhange, Gilles, Dirix, Piet, Gómez de Iturriaga Piña, Alfonso, Guckenberger, Matthias, Pasquier, David, Sargos, Paul, Scorsetti, Marta, Belka, Claus, Cirugía, radiología y medicina física, Kirurgia,erradiologia eta medikuntza fisikoa, Zilli, Thomas, Achard, Vérane, Dal Pra, Alan, Schmidt-Hegemann, Nina, Jereczek-Fossa, Barbara Alicja, Lancia, Andrea, Ingrosso, Gianluca, Alongi, Filippo, Aluwini, Shafak, Arcangeli, Stefano, Blanchard, Pierre, Conde Moreno, Antonio, Couñago, Felipe, Créhange, Gilles, Dirix, Piet, Gómez de Iturriaga Piña, Alfonso, Guckenberger, Matthias, Pasquier, David, Sargos, Paul, Scorsetti, Marta, and Belka, Claus

Abstract

Background and purpose: Oligometastatic prostate cancer is a new and emerging treatment field with only few prospective randomized studies published so far. Despite the lack of strong level I evidence, metastasis-directed therapies (MDT) are widely used in clinical practice, mainly based on retrospective and small phase 2 studies and with a large difference across centers. Pending results of ongoing prospec-tive randomized trials, there is a clear need for more consistent treatment indications and radiotherapy practices.Material and methods: A European Society for Radiotherapy and Oncology (ESTRO) Guidelines Committee consisting of radiation oncologists' experts in prostate cancer was asked to answer a dedicated question-naire, including 41 questions on the main controversial issues with regard to oligometastatic prostate cancer.Results: The panel achieved consensus on patient selection and routine use of prostate-specific mem-brane antigen positron emission tomography (PSMA PET) imaging as preferred staging and restaging imaging. MDT strategies are recommended in the de novo oligometastatic, oligorecurrent and oligopro-gressive disease setting for nodal, bone and visceral metastases. Radiation therapy doses, volumes and techniques were discussed and commented.Conclusion: These recommendations have the purpose of providing standardization and consensus to optimize the radiotherapy treatment of oligometastatic prostate cancer until mature results of random-ized trials are available.

Published
2022

57. Stereotactic radiotherapy for liver oligometastases

Author

Menichelli, Claudia, primary, Casamassima, Franco, additional, Aristei, Cynthia, additional, Ingrosso, Gianluca, additional, Borghesi, Simona, additional, Arcidiacono, Fabio, additional, Lancellotta, Valentina, additional, Franzese, Ciro, additional, and Arcangeli, Stefano, additional

Published
2022
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58. Stereotactic radiotherapy for lung oligometastases

Author

Falcinelli, Lorenzo, primary, Menichelli, Claudia, additional, Casamassima, Franco, additional, Aristei, Cynthia, additional, Borghesi, Simona, additional, Ingrosso, Gianluca, additional, Draghini, Lorena, additional, Tagliagambe, Angiolo, additional, Badellino, Serena, additional, and Buglione di Monale e Bastia, Michela, additional

Published
2022
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59. Stereotactic radiotherapy for bone oligometastases

Author

Colosimo, Caterina, primary, Pasqualetti, Francesco, additional, Aristei, Cynthia, additional, Borghesi, Simona, additional, Forte, Letizia, additional, Mignogna, Marcello, additional, Badii, Donatella, additional, Bosio, Manrico, additional, Paiar, Fabiola, additional, Nanni, Sara, additional, Bertocci, Silvia, additional, Lastrucci, Luciana, additional, Parisi, Silvana, additional, and Ingrosso, Gianluca, additional

Published
2022
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60. ARTO trial-(NCT03449719): Early results from a phase II randomized trial testing stereotactic body radiation therapy in patients with oligometastatic castration-resistant prostate cancer undergoing I line treatment with abiraterone acetate.

Author

Francolini, Giulio, primary, Detti, Beatrice, additional, Di Cataldo, Vanessa, additional, Caini, Saverio, additional, Alitto, Anna Rita, additional, Parisi, Silvana, additional, Demofonti, Chiara, additional, Bruni, Alessio, additional, Ingrosso, Gianluca, additional, Timon, Giorgia, additional, Allegra, Andrea, additional, Aquilano, Michele, additional, Ciccone, Lucia Pia, additional, Salvestrini, Viola, additional, Frosini, Giulio, additional, Cerbai, Cecilia, additional, Desideri, Isacco, additional, Meattini, Icro, additional, Mangoni, Monica, additional, and Livi, Lorenzo, additional

Published
2022
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62. Stereotactic radiotherapy for brain oligometastases

Author

Lupattelli, Marco, primary, Tini, Paolo, additional, Nardone, Valerio, additional, Aristei, Cynthia, additional, Borghesi, Simona, additional, Maranzano, Ernesto, additional, Anselmo, Paola, additional, Ingrosso, Gianluca, additional, Deantonio, Letizia, additional, and Buglione di Monale e Bastia, Michela, additional

Published
2021
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63. Interfraction prostate displacement during image-guided radiotherapy using intraprostatic fiducial markers and a cone-beam computed tomography system: A volumetric off-line analysis in relation to the variations of rectal and bladder volumes

Author

Ingrosso, Gianluca, Miceli, Roberto, Ponti, Elisabetta, Lancia, Andrea, Di Cristino, Daniela, De Pasquale, Francesco, Bove, Pierluigi, and Santoni, Riccardo

Subjects
Diagnosis, Usage, Prostate cancer -- Usage -- Diagnosis, Radiotherapy -- Usage, CAT scans -- Usage, Diagnostic imaging, Tomography
Published
2019

65. Dose-escalated pelvic radiotherapy for prostate cancer in definitive or postoperative setting

Author

Francolini, Giulio, primary, Stocchi, Giulia, additional, Detti, Beatrice, additional, Di Cataldo, Vanessa, additional, Bruni, Alessio, additional, Triggiani, Luca, additional, Guerini, Andrea Emanuele, additional, Mazzola, Rosario, additional, Cuccia, Francesco, additional, Mariotti, Matteo, additional, Salvestrini, Viola, additional, Garlatti, Pietro, additional, Borghesi, Simona, additional, Ingrosso, Gianluca, additional, Bellavita, Rita, additional, Aristei, Cynthia, additional, Desideri, Isacco, additional, and Livi, Lorenzo, additional

Published
2021
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66. Radiotherapy at oligoprogression for metastatic castration-resistant prostate cancer patients: a multi-institutional analysis

Author

Valeriani, Maurizio, primary, Detti, Beatrice, additional, Fodor, Andrei, additional, Caini, Saverio, additional, Borghesi, Simona, additional, Trippa, Fabio, additional, Triggiani, Luca, additional, Bruni, Alessio, additional, Russo, Donatella, additional, Saldi, Simonetta, additional, Di Staso, Mario, additional, Francolini, Giulio, additional, Lancia, Andrea, additional, Marinelli, Luca, additional, Di Muzio, Nadia, additional, Aristei, Cynthia, additional, Livi, Lorenzo, additional, Magrini, Stefano Maria, additional, and Ingrosso, Gianluca, additional

Published
2021
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68. Health-related quality of life 24 months after prostate cancer diagnosis: an update from the Pros-IT CNR prospective observational study

Author

Palumbo, Carlotta, Bruni, Alessio, Antonelli, Alessandro, Artibani, Walter, Bassi, Pierfrancesco, Bertoni, Filippo, Borghetti, Paolo, Bracarda, Sergio, Cicchetti, Alessandro, Corvò, Renzo, Gacci, Mauro, Ingrosso, Gianluca, Magrini, Stefano M, Maruzzo, Marco, Mirone, Vincenzo, Montironi, Rodolfo, Muto, Giovanni, Noale, Marianna, Porreca, Angelo, Russi, Elvio, Triggiani, Luca, Tubaro, Andrea, Valdagni, Riccardo, Maggi, Stefania, Conti, Giario N, and Ricardi, Umberto

Subjects
Male, Prostatectomy, Prostatic neoplasms, Quality of life, Patient reported outcomes measure, Radiotherapy, Watchful waiting, Urology, Prostatic Neoplasms, Androgen Antagonists, Humans, Quality of Life, Percutaneous Coronary Intervention, Nephrology
Abstract

This study analyzes patient health-related quality of life (QoL) 24-month after prostate cancer (PCa) diagnosis within the PROState cancer monitoring in ITaly from the National Research Council (Pros-IT CNR) study.Pros-IT CNR is an ongoing, longitudinal and observational study, considering a convenience sample of patients enrolled at PCa diagnosis and followed at 6, 12, 24, 36, 48 and 60 months from the diagnosis. Patients were grouped according to the treatment received: nerve sparing radical prostatectomy (NSRP), non-nerve sparing radical prostatectomy (NNSRP), radiotherapy (RT), RT plus androgen deprivation (RT plus ADT) and active surveillance (AS). QoL was measured through the Italian versions of SF-12 and UCLA-PCI questionnaires at diagnosis and at 6-12 and 24-month. The minimal clinically important difference (MCID) was defined as half a standard deviation of the baseline domain.Overall, 1537 patients were included in the study. The decline in urinary function exceeded the MCID at each timepoint only in the NSRP and NNSRP groups (at 24 months -14.7, P0.001 and -19.7, P0.001, respectively). The decline in bowel function exceeded the MCID only in the RT (-9.1, P=0.02) and RT plus ADT groups at 12 months (-10.3, P=0.001); after 24 months, most patients seem to recover their bowel complaints. The decline in sexual function exceeded the MCID at each timepoint in the NNSRP, NSRP and RT plus ADT groups (at 6 months -28.7, P0.001, -37.8, P0.001, -20.4, P0.001, respectively).Although all the treatments were relatively well-tolerated over the 24 month period following PCa diagnosis, each had a different impact on QoL.

Published
2021

69. How Has Prostate Cancer Radiotherapy Changed in Italy between 2004 and 2011? An Analysis of the National Patterns-Of-Practice (POP) Database by the Uro-Oncology Study Group of the Italian Society of Radiotherapy and Clinical Oncology (AIRO)

Author

Mazzeo, Ercole, primary, Triggiani, Luca, additional, Frassinelli, Luca, additional, Guarneri, Alessia, additional, Bartoncini, Sara, additional, Antognoni, Paolo, additional, Gottardo, Stefania, additional, Greco, Diana, additional, Borghesi, Simona, additional, Nanni, Sara, additional, Bruni, Alessio, additional, Ingrosso, Gianluca, additional, D’Angelillo, Rolando Maria, additional, Detti, Beatrice, additional, Francolini, Giulio, additional, Magli, Alessandro, additional, Guerini, Andrea Emanuele, additional, Arcangeli, Stefano, additional, Spiazzi, Luigi, additional, Ricardi, Umberto, additional, Lohr, Frank, additional, and Magrini, Stefano Maria, additional

Published
2021
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73. Radiotherapy in the era of COVID-19

Author

Lancia, Andrea, primary, Bonzano, Elisabetta, additional, Bottero, Marta, additional, Camici, Marta, additional, Catellani, Francesco, additional, and Ingrosso, Gianluca, additional

Published
2020
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77. Zinc‐L‐carnosine prevented dysphagia in breast cancer patients undergoing adjuvant radiotherapy: Results of a phase III randomized trial

Author

Saldi, Simonetta, primary, Perrucci, Elisabetta, additional, Fulcheri, Christian Paolo Luca, additional, Mariucci, Cristina, additional, Chierchini, Sara, additional, Ingrosso, Gianluca, additional, Falcinelli, Lorenzo, additional, Podlesko, Anna Maria, additional, Merluzzi, Mara, additional, Bini, Vittorio, additional, and Aristei, Cynthia, additional

Published
2020
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78. Health-related quality of life 24 months after prostate cancer diagnosis: an update from the Pros-IT CNR prospective observational study.

Author

PALUMBO, Carlotta, BRUNI, Alessio, ANTONELLI, Alessandro, ARTIBANI, Walter, BASSI, Pierfrancesco, BERTONI, Filippo, BORGHETTI, Paolo, BRACARDA, Sergio, CICCHETTI, Alessandro, CORVÒ, Renzo, GACCI, Mauro, INGROSSO, Gianluca, MAGRINI, Stefano M., MARUZZO, Marco, MIRONE, Vincenzo, MONTIRONI, Rodolfo, MUTO, Giovanni, NOALE, Marianna, PORRECA, Angelo, and RUSSI, Elvio

Published
2022
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79. Stereotactic radiotherapy for brain oligometastases.

Author

Lupattelli, Marco, Tini, Paolo, Nardone, Valerio, Aristei, Cynthia, Borghesi, Simona, Maranzano, Ernesto, Anselmo, Paola, Ingrosso, Gianluca, Deantonio, Letizia, and di Monale e Bastia, Michela Buglione

Abstract

Brain metastases, the most common metastases in adults, will develop in up to 40% of cancer patients, accounting for more than one-half of all intracranial tumors. They are most associated with breast and lung cancer, melanoma and, less frequently, colorectal and kidney carcinoma. Magnetic resonance imaging (MRI) is the gold standard for diagnosis. For the treatment plan, computed tomography (CT) images are co-registered and fused with a gadolinium-enhanced T1-weighted MRI where tumor volume and organs at risk are contoured. Alternatively, plain and contrast-enhanced CT scans are co-registered. Single-fraction stereotactic radiotherapy (SRT) is used to treat patients with good performance status and up to 4 lesions with a diameter of 30 mm or less that are distant from crucial brain function areas. Fractionated SRT (2-5 fractions) is used for larger lesions, in eloquent areas or in proximity to crucial or surgically inaccessible areas and to reduce treatment-related neurotoxicity. The single-fraction SRT dose, which depends on tumor diameter, impacts local control. Fractionated SRT may encompass different schedules. No randomized trial data compared the safety and efficacy of single and multiple fractions. Both single-fraction and fractionated SRT provide satisfactory local control rates, tolerance, a low risk of transient acute adverse events and of radiation necrosis the incidence of which correlated with the irradiated brain volume. [ABSTRACT FROM AUTHOR]

Published
2022
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80. Physician And Patient Barriers To Radiotherapy Service Access: Treatment Referral Implications

Author

Chierchini, Sara, Ingrosso, Gianluca, Saldi, Simonetta, Stracci, Fabrizio, and Aristei, Cynthia

Subjects
Barriers, Radiotherapy, Referral, Review, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282
Abstract

Sara Chierchini,1 Gianluca Ingrosso,1 Simonetta Saldi,1 Fabrizio Stracci,2 Cynthia Aristei1 1Radiation Oncology Section, Department of Surgical and Biomedical Sciences, University of Perugia and Perugia General Hospital, Perugia, Italy; 2Department of Experimental Medicine, Section of Public Health, University of Perugia, Perugia, ItalyCorrespondence: Gianluca IngrossoDepartment of Surgical and Biomedical Sciences, University of Perugia, Piazza Lucio Severi 1, Perugia 06132, ItalyTel +39-075-5783259Fax +39-075-5783614Email ingrosso.gianluca@gmail.comAbstract: Radiotherapy is one of the mainstays of cancer treatment, and about 60% of cancer patients receive this type of treatment during their course of treatment. An evident gap between optimal and actual radiotherapy utilization proportions has recently been reported, which has been ascribed to lack of referral to radiation oncology. There are many factors influencing the radiotherapy referral, including patient anxiety about toxicity, wrong perception of efficacy and side effects by physicians and patients, insufficient knowledge of referral process. These factors, defined as barriers can be categorized in health system barriers, physician and patient barriers. In the present brief narrative review, we discussed barriers to radiotherapy referral focusing on physician and patient barriers.Keywords: radiotherapy, referral, barriers

Published
2019

81. Cone-beam computed tomography in hypofractionated stereotactic radiotherapy for brain metastases

Author

Ingrosso Gianluca, Miceli Roberto, Fedele Dahlia, Ponti Elisabetta, Benassi Michaela, Barbarino Rosaria, Di Murro Luana, Giudice Emilia, Santarelli Federico, and Santoni Riccardo

Subjects
Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background To assess interfraction translational and rotational setup errors, in patients treated with image-guded hypofractionated stereotactic radiotherapy, immobilized by a thermoplastic mask and a bite-block and positioned using stereotactic coordinates. Methods 37 patients with 47 brain metastases were treated with hypofractionated stererotactic radiotherapy. All patients were immobilized with a combination of a thermoplastic mask and a bite-block fixed to a stereotactic frame support. Daily cone-beam CT scans were acquired for every patient before the treatment session and were matched online with planning CT images, for 3D image registration. The mean value and standard deviation of all translational (X, Y, Z) and rotational errors (θx, θy, θz) were calculated for the matching results of bone matching algorithm. Results A total of 194 CBCT scans were analyzed. Mean +/- standard deviation of translational errors (X, Y, Z) were respectively 0.5 +/- 1.6 mm (range -5.7 and 5.9 mm) in X; 0.4 +/- 2.7 mm (range -8.2 and 12.1 mm) in Y; 0.4 +/- 1.9 mm (range -7.0 and 14 mm) in Z; median and 90th percentile were respectively within 0.5 mm and 2.4 mm in X, 0.3 mm and 3.2 mm in Y, 0.3 mm and 2.2 mm in Z. Mean +/- standard deviation of rotational errors (θx, θy, θz) were respectively 0.0 degrees+/- 1.3 degrees (θx) (range -6.0 degrees and 3.1 degrees); -0.1 degrees +/- 1.1 degrees (θy) (range -3.0 degrees and 2.4 degrees); -0.6 degrees +/- 1.4 degrees (θz) (range -5.0 degrees and 3.3 degrees). Median and 90th percentile of rotational errors were respectively within 0.1 degrees and 1.4 degrees (θx), 0.0 degrees and 1.2 degrees (θy), 0.0 degrees and 0.9 degrees (θz). Mean +/- SD of 3D vector was 3.1 +/- 2.1 mm (range 0.3 and 14.9 mm); median and 90th percentile of 3D vector was within 2.7 mm and 5.1 mm. Conclusions Hypofractionated stereotactic radiotherapy have the significant limitation of uncertainty in interfraction repeatability of the patient setup; image-guided radiotherapy using cone-beam computed tomography improves the accuracy of the treatment delivery reducing set-up uncertainty, giving the possibility of 3-dimensional anatomic informations in the treatment position.

Published
2012
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84. Whole breast external beam radiotherapy in elderly patients affected by left-sided early breast cancer: a dosimetric comparison between two simple free-breathing techniques

Author

Carosi, Alessandra, primary, Ingrosso, Gianluca, additional, Turturici, Irene, additional, Valeri, Silvio, additional, Barbarino, Rosaria, additional, Di Murro, Luana, additional, Bottero, Marta, additional, Lancia, Andrea, additional, Ponti, Elisabetta, additional, Bruni, Alessio, additional, Bonzano, Elisabetta, additional, Saldi, Simonetta, additional, Andolina, Maria, additional, Aristei, Cynthia, additional, and Santoni, Riccardo, additional

Published
2019
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85. Predicting genitourinary toxicity in three-dimensional conformal radiotherapy for localized prostate cancer: A dose-volume parameters analysis of the bladder

Author

Bagalà, Paolo, Ingrosso, Gianluca, Falco, Maria, Petrichella, Sara, D'Andrea, Marco, Rago, Maria, Lancia, Andrea, Bruni, Claudia, Ponti, Elisabetta, and Santoni, Riccardo

Subjects
Care and treatment, Complications and side effects, Risk factors, Urologic diseases -- Risk factors, Radiotherapy -- Complications and side effects, Prostate cancer -- Care and treatment
Published
2016

86. Linee Guida AIRO-AIRB 2018: Neoplasie della Vescica [AIRO-AIRB Guidelines 2018: Neoplasms of the Bladder]

Author

Magrini, Stefano Maria, Santoni, Riccardo, Corvo, Renzo, Alongi, Filippo, Bertoni, Filippo, Jereczek-Fossa, Barbara Alicja, D'Angelillo, Rolando Maria, Arcangeli, Stefano, Augurio, Antonietta, Belgioia, Liliana, Bellavita, Rita, Borghesi, Simona, Bruni, Alessio, Buglione, Michela, Cardone, Gianpiero, D'Agostino, Giuseppe Roberto, Fersino, Sergio, Genovesi, Domenico, Hurle, Rodolfo, Ingrosso, Gianluca, Lohr, Frank, Maccagnano, Carmen, Mazzeo, Ercole, Mortellaro, Gianluca, Munari, Enrico, Muto, Matteo, Nole, Franco, Palumbo, Isabella, Pasinetti, Nadia, Silvestro, Giustino, Triggiani, Luca, Vinciguerra, Annamaria, Zamboni, Giuseppe, Pergolizzi, Stefano, Russi, Elvio, Tombolini, Vincenzo, Cavalleri, Stefano, Caffo, Orazio, and Zerini, Dario

Subjects
TRANSITIONAL-CELL-CARCINOMA, BACILLUS-CALMETTE-GUERIN, PHASE-III TRIAL, INTENSITY-MODULATED RADIOTHERAPY, METASTATIC UROTHELIAL CARCINOMA, GEMCITABINE PLUS CISPLATIN, LONG-TERM OUTCOMES, COMBINED-MODALITY THERAPY, QUALITY-OF-LIFE, CHEMOTHERAPY FOLLOWING CYSTECTOMY
Published
2018

87. Endoscopic Intravesical Fibrin Glue Application in the Treatment of Refractory Hemorrhagic Radiation Cystitis: A Single Cohort Pilot Study

Author

Bove, Pierluigi, primary, Iacovelli, Valerio, additional, Tirindelli, Maria Cristina, additional, Bianchi, Daniele, additional, Flammia, Gerardo Paolo, additional, Cipriani, Chiara, additional, Ferraro, Angelo Salvatore, additional, Ferro, Matteo, additional, Arcese, William, additional, Ingrosso, Gianluca, additional, Vespasiani, Giuseppe, additional, and Finazzi Agrò, Enrico, additional

Published
2019
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90. Transient effects of tumor location on the functional architecture at rest in glioblastoma patients: three longitudinal case studies

Author

Tuovinen, Noora, de Pasquale, Francesco, Caulo, Massimo, Caravasso, Chiara Falletta, Giudice, Emilia, Miceli, Roberto, Ingrosso, Gianluca, Laprie, Anne, Santoni, Riccardo, and Sabatini, Umberto

Subjects
Pathology, medicine.medical_specialty, Brain tumor, Lesion, 03 medical and health sciences, Functional connectivity, 0302 clinical medicine, Radiotherapy, Resting-state fMRI, Cortex (anatomy), Image Interpretation, Computer-Assisted, medicine, Humans, Radiology, Nuclear Medicine and imaging, Longitudinal Studies, Aged, medicine.diagnostic_test, Resting state fMRI, Supplementary motor area, business.industry, Brain Neoplasms, Node (networking), Research, Middle Aged, medicine.disease, Magnetic Resonance Imaging, medicine.anatomical_structure, Oncology, Radiology Nuclear Medicine and imaging, 030220 oncology & carcinogenesis, Posterior cingulate, Female, medicine.symptom, Functional magnetic resonance imaging, business, Glioblastoma, 030217 neurology & neurosurgery
Abstract

Background: The cognitive function of brain tumor patients is affected during the treatment. There is evidence that gliomas and surgery alter the functional brain connectivity but studies on the longitudinal effects are lacking.Methods: We acquired longitudinal (pre- and post-radiotherapy) resting-state functional magnetic resonance imaging on three selected glioblastoma patients. These cases were selected to study three models: a lesion involving a functional hub within a central system, a lesion involving a peripheral node within a central system and a lesion involving a peripheral node of a non-central system.Results: We found that, as expected, the tumor lesion affects connections in close vicinity, but when the lesion relates to a functional hub, these changes involve long-range connections leading to diverse connectivity profiles pre- and post-radiotherapy. In particular, a global but temporary improvement in the post-radiotherapy connectivity was obtained when treating a lesion close to a network hub, such as the posterior Cingulate Cortex.Conclusions: This suggests that this node re-establishes communication to nodes further away in the network. Eventually, these observed effects seem to be transient and on the long-term the tumor burden leads to an overall decline of connectivity following the course of the pathology. Furthermore, we obtained that the link between hubs, such as the Supplementary Motor Area and posterior Cingulate Cortex represents an important backbone by means of which within and across network communication is handled: the disruption of this connection seems to imply a strong decrease in the overall connectivity.

Published
2016
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91. Three-Tesla Magnetic Resonance and Computed Tomography Imaging in Three-Dimensional Conformal Radiotherapy for Localized Prostate Cancer

Author

Bove Pierluigi, Ponti Elisabetta, Ingrosso Gianluca, Santoni Riccardo, and Carosi Alessandra

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Rectum, Computed tomography, Magnetic resonance imaging, Conformal radiotherapy, medicine.disease, Radiation therapy, Prostate cancer, medicine.anatomical_structure, Prostate, Medicine, Radiology, Three dimensional conformal radiotherapy, business, Nuclear medicine
Abstract

Aims and background: we evaluate CT-3Tesla MRI fusion in conformal radiotherapy for localized prostate cancer.Methods: 18 consecutive patients underwent a 3T MRI scan under radiotherapy planning conditions, after the CT scan. Bowel and bladder preparation were prescribed. CT and MR images were automatically fused; prostate and seminal vesicles were contoured on CT and on MRI, organs at risk were defined on CT-MRI fusion. Late rectal and sexual toxicity, differences in target volume between MRI and CT and differences in rectal and penile bulb dose distribution based on CT only or on CT-MRI fusion were evaluated.Results: one patient experienced a late rectal toxicity; no patient had sexual toxicity. The difference between the mean MRI and CT target volumes was statistically significant (p = 0.0001 paired Student's t-test). The dose-volume histogram (DVH) analysis shows a significant reduction of the dose received by the rectum and the penile bulb in MRI-plans compared to CT-plans.Conclusions: 3 Tesla MRI scan under radiotherapy planning conditions along with bowel preparation significantly improves the definition of the target volume sparing normal tissue irradiation.

Published
2011
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93. Oligometastatic cancer: stereotactic ablative radiotherapy for patients affected by isolated body metastasis

Author

Lancia, Andrea, primary, Ingrosso, Gianluca, additional, Carosi, Alessandra, additional, Di Murro, Luana, additional, Giudice, Emilia, additional, Cicchetti, Sara, additional, Morelli, Pasquale, additional, di Cristino, Daniela, additional, Bruni, Claudia, additional, Murgia, Alessandra, additional, Cancelli, Alessandro, additional, Turturici, Irene, additional, Iadevaia, Anjali, additional, Ponti, Elisabetta, additional, and Santoni, Riccardo, additional

Published
2017
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94. Efficacy of stereotactic body radiotherapy in oligorecurrent and in oligoprogressive prostate cancer: new evidence from a multicentric study

Author

Triggiani, Luca, primary, Alongi, Filippo, additional, Buglione, Michela, additional, Detti, Beatrice, additional, Santoni, Riccardo, additional, Bruni, Alessio, additional, Maranzano, Ernesto, additional, Lohr, Frank, additional, D’Angelillo, Rolando, additional, Magli, Alessandro, additional, Bonetta, Alberto, additional, Mazzola, Rosario, additional, Pasinetti, Nadia, additional, Francolini, Giulio, additional, Ingrosso, Gianluca, additional, Trippa, Fabio, additional, Fersino, Sergio, additional, Borghetti, Paolo, additional, Ghirardelli, Paolo, additional, and Magrini, Stefano Maria, additional

Published
2017
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95. Pros-IT CNR: an Italian prostate cancer monitoring project

Author

Bassi, Pierfrancesco, Maggi, Ilaria Stefania, Artibani, Walter, Bassi, Pier Francesco, Bertoni, Filippo, Bracarda, Sergio, Conti, Giario Natale, Corvò, Renzo, Gacci, Mauro, Graziotti, Pierpaolo, Magrini, Stefano Maria, Maurizi Enrici, Riccardo, Mirone, Vincenzo, Montironi, Rodolfo, Muto, Giovanni, Pecoraro, Stefano, Porreca, Angelo, Ricardi, Umberto, Tubaro, Andrea, Zagonel, Vittorina, Zattoni, Filiberto, Crepaldi, Gaetano, Noale, Marianna, Alitto, Anna Rita, Ambrosi, Enrica, Antonelli, Alessandro, Aristei, Cynthia, Barbieri, Michele, Bardari, Franco, Bardoscia, Lilia, Barra, Salvina, Bartoncini, Sara, Basso, Umberto, Becherini, Carlotta, Bellavita, Rita, Bergamaschi, Franco, Berlingheri, Stefania, Berruti, Alfredo, Borghesi, Marco, Bortolus, Roberto, Borzillo, Valentina, Bosetti, Davide, Bove, Giuseppe, Bove, Pierluigi, Brausi, Maurizio, Bruni, Alessio, Baldari, Giorgio Bruno Cristiano, Brunocilla, Eugenio, Buffoli, Alberto, Buglione, Michela, Buttigliero, Consuelo, Cacciamani, Giovanni, Caldiroli, Michela, Cardo, Giuseppe, Carmignani, Giorgio, Carrieri, Giuseppe, Castelli, Emanuele, Castrezzati, Elisabetta, Catalano, Gianpiero, Cattarino, Susanna, Catucci, Francesco, Cavallini Francolini, Dario, Ceccarini, Ofelia, Celia, Antonio, Chiancone, Francesco, Chini, Tommaso, Cianci, Claudia, Cisternino, Antonio, Collura, Devi, Corbella, Franco, Corinti, Matteo, Corsi, Paolo, Cortese, Fiorenza, Corti, Luigi, de Nunzio, Cosimo, Cristiano, Olga, D'Angelillo, Rolando Maria, Da Pozzo, Luigi, D'Agostino, Daniele, D’Andrea, David, Dandrea, Matteo, De Angelis, Michele, De Cobelli, Ottavio, De Concilio, Bernardino, De Lisa, Antonello, De Luca, Stefano, De Stefani, Agostina, Deantoni, Chiara Lucrezia, Degli Esposti, Claudio, Destito, Anna, Detti, Beatrice, Di Muzio, Nadia, Di Stasio, Andrea, Di Stefano, Calogero, Di Trapani, Danilo, Difino, Giuseppe, Falivene, Sara, Farullo, Giuseppe, Fedelini, Paolo, Ferrari, Ilaria, Ferrau, Francesco, Ferro, Matteo, Fodor, Andrei, Fontana, Francesco, Francesca, Francesco, Giulio, Francolini, Frata, Paolo, Frezza, Giovanni, Gabriele, Pietro, Galeandro, Maria, Garibaldi, Ida Marina Elisabetta, Gennari, Pietro, Gentilucci, Alessandro, Giacobbe, Alessandro, Giussani, Laura, Giusti, Giuseppe, Gontero, Paolo, Guarneri, Alessia, Guida, Cesare, Gurioli, Alberto, Huqi, Dorijan, Imbimbo, Ciro, Ingrosso, Gianluca, Iotti, Cinzia, Italia, Corrado, La Mattina, Pierdaniele, Lamanna, Enza, Lastrucci, Luciana, Lazzari, Grazia, Liberale, Fabiola, Liguori, Giovanni, Lisi, Roberto, Lohr, Frank, Lombardo, Riccardo, Lovisolo, Jon, Ludovico, Giuseppe Mario, Macchione, Nicola, Maggio, Francesca, Malizia, Michele, Manasse, Gianluca, Mandoliti, Giovanni, Mantini, Giovanna, Marafioti, Luigi, Marciello, Luisa, Marconi, Alberto Mario, Martillotta, Antonietta, Marzano, Salvino, Masciullo, Stefano, Maso, Gloria, Massenzo, Adele, Mazzeo, Ercole, Mearini, Luigi, Medoro, Serena, Molè, Rosa, Monesi, Giorgio, Montanari, Emanuele, Montefiore, Franco, Montesi, Giampaolo, Morgia, Giuseppe, Moro, Gregorio, Muscas, Giorgio, Musio, Daniela, Muto, Paolo, Muzzonigro, Giovanni, Napodano, Giorgio, Negro, Carlo Luigi Augusto, Nidini, Mattia, Ntreta, Maria, Orsatti, Marco, Palazzolo, Carmela, Palumbo, Isabella, Parisi, Alessandro, Parma, Paolo, Pavan, Nicola, Pericolini, Martina, Pinto, Francesco, Pistone, Antonio, Pizzuti, Valerio, Platania, Angelo, Polli, Caterina, Pomara, Giorgio, Ponti, Elisabetta, Porcaro, Antonio Benito, Porpiglia, Francesco, Pugliese, Dario, Pycha, Armin, Raguso, Giuseppe, Rampini, Andrea, Randone, Donato Franco, Roscigno, Marco, Ruggieri, Maria Paola, Ruoppo, Giuseppe, Sanseverino, Roberto, Santacaterina, Anna, Santarsieri, Michele, Santoni, Riccardo, Scagliarini, Sarah, Scagliotti, Giorgio Vittorio, Scanzi, Mauro, Scarcia, Marcello, Schiavina, Riccardo, Sciarra, Alessandro, Sciorio, Carmine, Scolaro, Tindaro, Scuzzarella, Salvatore, Selvaggio, Oscar, Serao, Armando, Serni, Sergio, Signor, Marco Andrea, Silvani, Mauro, Silvano, Giovanni, Silvestris, Franco, Simeone, Claudio, Simone, Valeria, Spagnoletti, Girolamo, Spinelli, Matteo Giulio, Squillace, Luigi, Tombolini, Vincenzo, Toninelli, Mariastella, Triggiani, Luca, Trinchieri, Alberto, Trodella, Luca Eolo, Trodella, Lucio, Trombetta, Carlo, Tronnolone, Lidia, Tucci, Marcello, Urzì, Daniele, Valdagni, Riccardo, Valeriani, Maurizio, Vanoli, Maurizio, Vitali, Elisabetta, Zaramella, Stefano, Zeccolini, Guglielmo, Zini, Giampaolo, Noale, Marianna (ORCID:0000-0002-4313-8427), Maggi, Stefania, D’Angelillo, Rolando, D’agostino, Daniele, Mantini, Giovanna (ORCID:0000-0001-5303-4499), Bassi, Pierfrancesco, Maggi, Ilaria Stefania, Artibani, Walter, Bassi, Pier Francesco, Bertoni, Filippo, Bracarda, Sergio, Conti, Giario Natale, Corvò, Renzo, Gacci, Mauro, Graziotti, Pierpaolo, Magrini, Stefano Maria, Maurizi Enrici, Riccardo, Mirone, Vincenzo, Montironi, Rodolfo, Muto, Giovanni, Pecoraro, Stefano, Porreca, Angelo, Ricardi, Umberto, Tubaro, Andrea, Zagonel, Vittorina, Zattoni, Filiberto, Crepaldi, Gaetano, Noale, Marianna, Alitto, Anna Rita, Ambrosi, Enrica, Antonelli, Alessandro, Aristei, Cynthia, Barbieri, Michele, Bardari, Franco, Bardoscia, Lilia, Barra, Salvina, Bartoncini, Sara, Basso, Umberto, Becherini, Carlotta, Bellavita, Rita, Bergamaschi, Franco, Berlingheri, Stefania, Berruti, Alfredo, Borghesi, Marco, Bortolus, Roberto, Borzillo, Valentina, Bosetti, Davide, Bove, Giuseppe, Bove, Pierluigi, Brausi, Maurizio, Bruni, Alessio, Baldari, Giorgio Bruno Cristiano, Brunocilla, Eugenio, Buffoli, Alberto, Buglione, Michela, Buttigliero, Consuelo, Cacciamani, Giovanni, Caldiroli, Michela, Cardo, Giuseppe, Carmignani, Giorgio, Carrieri, Giuseppe, Castelli, Emanuele, Castrezzati, Elisabetta, Catalano, Gianpiero, Cattarino, Susanna, Catucci, Francesco, Cavallini Francolini, Dario, Ceccarini, Ofelia, Celia, Antonio, Chiancone, Francesco, Chini, Tommaso, Cianci, Claudia, Cisternino, Antonio, Collura, Devi, Corbella, Franco, Corinti, Matteo, Corsi, Paolo, Cortese, Fiorenza, Corti, Luigi, de Nunzio, Cosimo, Cristiano, Olga, D'Angelillo, Rolando Maria, Da Pozzo, Luigi, D'Agostino, Daniele, D’Andrea, David, Dandrea, Matteo, De Angelis, Michele, De Cobelli, Ottavio, De Concilio, Bernardino, De Lisa, Antonello, De Luca, Stefano, De Stefani, Agostina, Deantoni, Chiara Lucrezia, Degli Esposti, Claudio, Destito, Anna, Detti, Beatrice, Di Muzio, Nadia, Di Stasio, Andrea, Di Stefano, Calogero, Di Trapani, Danilo, Difino, Giuseppe, Falivene, Sara, Farullo, Giuseppe, Fedelini, Paolo, Ferrari, Ilaria, Ferrau, Francesco, Ferro, Matteo, Fodor, Andrei, Fontana, Francesco, Francesca, Francesco, Giulio, Francolini, Frata, Paolo, Frezza, Giovanni, Gabriele, Pietro, Galeandro, Maria, Garibaldi, Ida Marina Elisabetta, Gennari, Pietro, Gentilucci, Alessandro, Giacobbe, Alessandro, Giussani, Laura, Giusti, Giuseppe, Gontero, Paolo, Guarneri, Alessia, Guida, Cesare, Gurioli, Alberto, Huqi, Dorijan, Imbimbo, Ciro, Ingrosso, Gianluca, Iotti, Cinzia, Italia, Corrado, La Mattina, Pierdaniele, Lamanna, Enza, Lastrucci, Luciana, Lazzari, Grazia, Liberale, Fabiola, Liguori, Giovanni, Lisi, Roberto, Lohr, Frank, Lombardo, Riccardo, Lovisolo, Jon, Ludovico, Giuseppe Mario, Macchione, Nicola, Maggio, Francesca, Malizia, Michele, Manasse, Gianluca, Mandoliti, Giovanni, Mantini, Giovanna, Marafioti, Luigi, Marciello, Luisa, Marconi, Alberto Mario, Martillotta, Antonietta, Marzano, Salvino, Masciullo, Stefano, Maso, Gloria, Massenzo, Adele, Mazzeo, Ercole, Mearini, Luigi, Medoro, Serena, Molè, Rosa, Monesi, Giorgio, Montanari, Emanuele, Montefiore, Franco, Montesi, Giampaolo, Morgia, Giuseppe, Moro, Gregorio, Muscas, Giorgio, Musio, Daniela, Muto, Paolo, Muzzonigro, Giovanni, Napodano, Giorgio, Negro, Carlo Luigi Augusto, Nidini, Mattia, Ntreta, Maria, Orsatti, Marco, Palazzolo, Carmela, Palumbo, Isabella, Parisi, Alessandro, Parma, Paolo, Pavan, Nicola, Pericolini, Martina, Pinto, Francesco, Pistone, Antonio, Pizzuti, Valerio, Platania, Angelo, Polli, Caterina, Pomara, Giorgio, Ponti, Elisabetta, Porcaro, Antonio Benito, Porpiglia, Francesco, Pugliese, Dario, Pycha, Armin, Raguso, Giuseppe, Rampini, Andrea, Randone, Donato Franco, Roscigno, Marco, Ruggieri, Maria Paola, Ruoppo, Giuseppe, Sanseverino, Roberto, Santacaterina, Anna, Santarsieri, Michele, Santoni, Riccardo, Scagliarini, Sarah, Scagliotti, Giorgio Vittorio, Scanzi, Mauro, Scarcia, Marcello, Schiavina, Riccardo, Sciarra, Alessandro, Sciorio, Carmine, Scolaro, Tindaro, Scuzzarella, Salvatore, Selvaggio, Oscar, Serao, Armando, Serni, Sergio, Signor, Marco Andrea, Silvani, Mauro, Silvano, Giovanni, Silvestris, Franco, Simeone, Claudio, Simone, Valeria, Spagnoletti, Girolamo, Spinelli, Matteo Giulio, Squillace, Luigi, Tombolini, Vincenzo, Toninelli, Mariastella, Triggiani, Luca, Trinchieri, Alberto, Trodella, Luca Eolo, Trodella, Lucio, Trombetta, Carlo, Tronnolone, Lidia, Tucci, Marcello, Urzì, Daniele, Valdagni, Riccardo, Valeriani, Maurizio, Vanoli, Maurizio, Vitali, Elisabetta, Zaramella, Stefano, Zeccolini, Guglielmo, Zini, Giampaolo, Noale, Marianna (ORCID:0000-0002-4313-8427), Maggi, Stefania, D’Angelillo, Rolando, D’agostino, Daniele, and Mantini, Giovanna (ORCID:0000-0001-5303-4499)

Abstract

Aims: The Pros-IT CNR project aims to monitor a sample of Italian males ≥18 years of age who have been diagnosed in the participating centers with incident prostate cancer, by analyzing their clinical features, treatment protocols and outcome results in relation to quality of life. Methods: Pros-IT CNR is an observational, prospective, multicenter study. The National Research Council (CNR), Neuroscience Institute, Aging Branch (Padua) is the promoting center. Ninety-seven Italian centers located throughout Italy were involved. The field study began in September 1, 2014. Subjects eligible were diagnosed with biopsy-verified prostate cancer, naà ̄ve. A sample size of 1500 patients was contemplated. A baseline assessment including anamnestic data, clinical history, risk factors, the initial diagnosis, cancer staging information and quality of life (Italian UCLA Prostate Cancer Index; SF-12 Scale) was completed. Six months after the initial diagnosis, a second assessment evaluating the patient’s health status, the treatment carried out, and the quality of life will be made. A third assessment, evaluating the treatment follow-up and the quality of life, will be made 12 months after the initial diagnosis. The 4th, 5th, 6th and 7th assessments, similar to the third, will be completed 24, 36, 48 and 60 months after the initial diagnosis, respectively, and will include also a Food Frequency Questionnaire and the Physical Activity Scale for the Elderly. Discussion: The study will provide information on patients’ quality of life and its variations over time in relation to the treatments received for the prostate cancer.

Published
2017

97. Stereotactic body radiotherapy in oligometastatic prostate cancer patients with isolated lymph nodes involvement: a two-institution experience

Author

Ingrosso, Gianluca, primary, Trippa, Fabio, additional, Maranzano, Ernesto, additional, Carosi, Alessandra, additional, Ponti, Elisabetta, additional, Arcidiacono, Fabio, additional, Draghini, Lorena, additional, Di Murro, Luana, additional, Lancia, Andrea, additional, and Santoni, Riccardo, additional

Published
2016
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98. Combining abiraterone and radiotherapy in metastatic castration-resistant prostate cancer: a review of current evidence

Author

Livi, Lorenzo, Detti, Beatrice, Francolini, Giulio, Terziani, Francesca, Triggiani, Luca, D’Angelillo, Rolando M., and Ingrosso, Gianluca

Abstract

Prostate cancer is the second most frequent cancer worldwide, with a very high rate of progression despite treatment. The most aggressive form of the disease is known as castration-resistant prostate cancer, which carries a poor prognosis. We reviewed available literature regarding the combination of abiraterone acetate antihormonal drug and ablative radiation therapy for the treatment of metastatic castration-resistant prostate cancer. This dual treatment may enhance the effects of second-line hormonal therapy, as radiotherapy renders cancer cells more prone to immune-mediated cytotoxicity. Moreover, radiotherapy exerts its effect both on directly irradiated cells and on other distant tissues, with an abscopal effect, already demonstrated in other solid tumors. This combination treatment is safe and effective, with few adverse events. Moreover, it is of paramount importance in patients with oligoprogression of the primary disease, when current guidelines recommend continuing abiraterone treatment. Ablative radiation therapy is a noninvasive, nontoxic treatment with very high efficacy on local tumor growth control. In the available literature, the combination of radiation therapy and abiraterone acetate has prolonged both overall survival and progression-free survival, with a positive impact also on locoregional recurrence and distant metastases.

Published
2019
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100. Acute and Late Toxicity after Three-Dimensional Conformal Image-Guided Radiotherapy for Localized Prostate Cancer

Author

Ingrosso, Gianluca, primary, Carosi, Alessandra, additional, Ponti, Elisabetta, additional, Murgia, Alessandra, additional, di Cristino, Daniela, additional, Barbarino, Rosaria, additional, Benassi, Michaela, additional, Di Murro, Luana, additional, Giudice, Emilia, additional, Bove, Pierluigi, additional, and Santoni, Riccardo, additional

Published
2014
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