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94 results on '"Iizumi, Takashi"'

53. Transitions of Liver and Biliary Enzymes during Proton Beam Therapy for Hepatocellular Carcinoma

Author

Sumiya, Taisuke, primary, Mizumoto, Masashi, additional, Oshiro, Yoshiko, additional, Baba, Keiichiro, additional, Murakami, Motohiro, additional, Shimizu, Shosei, additional, Nakamura, Masatoshi, additional, Hiroshima, Yuichi, additional, Ishida, Toshiki, additional, Iizumi, Takashi, additional, Saito, Takashi, additional, Numajiri, Haruko, additional, Nakai, Kei, additional, Okumura, Toshiyuki, additional, and Sakurai, Hideyuki, additional

Published
2020
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54. Indicator for local recurrence of hepatocellular carcinoma after proton beam therapy: analysis of attenuation difference between the irradiated tumor and liver parenchyma on contrast enhancement CT

Author

Takahashi, Hiroaki, primary, Sekino, Yuta, additional, Mori, Kensaku, additional, Okumura, Toshiyuki, additional, Nasu, Katsuhiro, additional, Fukuda, Kuniaki, additional, Masuoka, Sota, additional, Iizumi, Takashi, additional, Hasegawa, Naoyuki, additional, Sakurai, Hideyuki, additional, and Minami, Manabu, additional

Published
2020
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55. Chronoradiation Therapy for Prostate Cancer:Morning Proton Beam Therapy Ameliorates Worsening Lower Urinary Tract Symptoms

Author

Negoro, Hiromitsu, Iizumi, Takashi, Mori, Yutaro, Matsumoto, Yoshitaka, Chihara, Ichiro, Hoshi, Akio, Sakurai, Hideyuki, Nishiyama, Hiroyuki, Ishikawa, Hitoshi, Yoshitaka, Matsumoto, Hideyuki, Sakurai, Hiroyuki, Nishiyama, and Hitoshi, Ishikawa

Subjects
urologic and male genital diseases
Abstract

Background and Purpose: Worsening lower urinary tract symptoms (LUTS) are a frequent adverse event following proton beam therapy (PBT) for localized prostate cancer. We investigated the dierences in worsening LUTS among patients who received PBT at dierent times of day. Participants and Methods: Among 173 patients who underwent PBT for prostate cancer, 168 patients (median age 68.5 years) completed international prostate symptom score (IPSS) questionnaires and were included. Changes in the IPSS from baseline to the end of PBT were assessed by multiple linear regression analysis for age, National Comprehensive Cancer Network risk classification, androgen deprivation therapy, fractional PBT dose, clinical target volume, severity of IPSS, diabetes, LUTS medication use before PBT, anti-coagulant therapy and radiation time of day (morning (08:30–10:30), around noon (10:31–14:30), and late afternoon (14:31–16:30)). Results: IPSS total score and IPSS-Quality of Life (QoL) score (12 patients were excluded due to missing IPSS-QoL score) increased from eight to 14.9 (p < 0.0001) and from two to four (p < 0.0001), respectively. Time of day (morning) was the only determinant for worsening LUTS ( = ????0.24, p < 0.01), voiding subscore ( = ????0.22, p < 0.05) and IPSS-QoL ( = ????0.27, p < 0.005), and was a determinant in item four (urgency) ( = ????0.28, p < 0.005) with age ( = 0.19, p < 0.05). Conclusions: Morning PBT for localized prostate cancer significantly ameliorated worsening LUTS and improved QoL compared with treatment around noon or late afternoon. Chronoradiation therapy for localized prostate cancer may be eective and further research to elucidate the underlying mechanism is warranted.

Published
2020

57. Angiographic Findings in Patients with Hepatocellular Carcinoma Previously Treated Using Proton Beam Therapy

Author

Takahashi, Hiroaki, primary, Mori, Kensaku, additional, Sekino, Yuta, additional, Okumura, Toshiyuki, additional, Hiyama, Takashi, additional, Fukuda, Kuniaki, additional, Hasegawa, Naoyuki, additional, Sakai, Masafumi, additional, Kikuchi, Shunsuke, additional, Takei, Yohei, additional, Iizumi, Takashi, additional, Sakurai, Hideyuki, additional, and Minami, Manabu, additional

Published
2019
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60. Capacity of proton beams in preserving normal liver tissue during proton beam therapy for hepatocellular carcinoma.

Author

Tsai, Yu-Lun, Takei, Hideyuki, Iizumi, Takashi, Okumura, Toshiyuki, Sekino, Yuta, Numajiri, Haruko, Ishikawa, Hitoshi, Sakae, Takeji, and Sakurai, Hideyuki

Subjects
HEPATOCELLULAR carcinoma, PROTON beams
Abstract

Unirradiated liver volume (ULV) preservation rate is an important factor associated with radiation-induced liver disease (RILD) in patients with hepatocellular carcinoma (HCC) undergoing proton beam therapy (PBT). The purpose of this study is to identify the predictors for ULV preservation and quantify the capacity of proton beams in normal liver sparing during PBT. We reviewed planning data of 92 patients with single intrahepatic HCC tumors undergoing PBT. The potential clinical and planning factors that may affect ULV preservation were involved in multiple linear regression for ULV preservation rate. The significant factors were determined to be predictors and their influences were quantified. The median ULV preservation rate was 62.08%. All the assessed clinical factors showed significant effects on ULV preservation rate: clinical target volume (CTV), P  < 0.001; portal vein tumor thrombosis (PVTT), P  = 0.010; left lobe tumor, P  = 0.010. In contrast, none of the planning factors demonstrated significance. The coefficients of significant factors in multiple linear regression were 60.85 for intercept, −0.02 for CTV, −9.01 for PVTT and 8.31 for left lobe tumors. The capacity of proton beams to spare normal liver tissue during PBT for HCC is mainly affected by clinical factors. The baseline of the ULV preservation rate is 60.85%, decreasing 0.02% with each milliliter of CTV increase and 9.01% for tumors with PVTT, and increasing 8.31% for tumors limited to the left lobe. Further clinical studies should be carried out to correlate our dosimetric findings with clinical outcomes. [ABSTRACT FROM AUTHOR]

Published
2021
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73. Monitoring method for automated CD-SEM recipes

Author

Maeda, Tatsuya, primary, Iwama, Satoru, additional, Nishihara, Makoto, additional, Berger, Daniel, additional, Berger, Andrew, additional, Ueda, Kazuhiro, additional, Kenichi, Takenouchi, additional, and Iizumi, Takashi, additional

Published
2005
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80. Total Synthesis of the Sesquiterpene (−)-Merrillianin

Author

Shiina, Isamu, Iizumi, Takashi, Taniguchi, Saori, Sugimoto, Masuhiro, Shimazaki, Takahisa, Yamai, Yu-suke, Ogawa, Go, Yamada, Tetsuro, Shinohara, Shojiro, Kageyama, Yosuke, Kuboki, Teppei, Suwa, Yuki, Yonekura, Keita, Ito, Keiichi, Toyoyama, Kiyotaka, Tateyama, Satoru, Mori, Takahiro, and Murata, Takatsugu

Abstract

The first total synthesis of (−)-merrillianin (1), which is a natural sesquiterpene with a tricyclic structure having a cyclopentane ring and five- and seven-membered lactone parts, is demonstrated. This asymmetric total synthesis enabled the absolute stereostructure determination of naturally occurring (−)-1.

Published
2023
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92. Characterization of Line-Edge Roughness in Cu/Low-k Interconnect Pattern.

Author

Yamaguchi, Atsuko, Ryuzaki, Daisuke, Takeda, Ken-ichi, Yamamoto, Jiro, Kawada, Hiroki, and Iizumi, Takashi

Abstract

To establish a method of measuring interconnect line-edge roughness (LER), low-k line patterns were observed and electric field concentration was simulated on the basis of observation results. Wedge-shaped LERs were observed at the edges of low-k lines, and the bottom and the top widths of the average wedge feature were 60 and 7 nm (or smaller), respectively. Simulation showed that LER causes serious electric field concentration, which may cause the degradation of time-dependent dielectric breakdown (TDDB) lifetime at 100-nm-pitch Cu/low-k interconnects. The maximum electric field strength depends on the conventional LER metric 3Rq, but depends more strongly on the wedge angle, the curvature of the tip. That is, other metrics such as wedge angle can predict fatal electric field concentration caused by LER than the conventional metric 3Rq. [ABSTRACT FROM AUTHOR]

Published
2008
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93. Total Synthesis of the Sesquiterpene (-)-Merrillianin.

Author

Shiina I, Iizumi T, Taniguchi S, Sugimoto M, Shimazaki T, Yamai YS, Ogawa G, Yamada T, Shinohara S, Kageyama Y, Kuboki T, Suwa Y, Yonekura K, Ito K, Toyoyama K, Tateyama S, Mori T, and Murata T

Abstract

The first total synthesis of (-)-merrillianin ( 1 ), which is a natural sesquiterpene with a tricyclic structure having a cyclopentane ring and five- and seven-membered lactone parts, is demonstrated. This asymmetric total synthesis enabled the absolute stereostructure determination of naturally occurring (-)- 1 .

Published
2024
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94. Long-term follow up of a patient with a recurrent desmoid tumor that was successfully treated with proton beam therapy: A case report and literature review.

Author

Sawada T, Mizumoto M, Oshiro Y, Numajiri H, Shimizu S, Hiroshima Y, Nakamura M, Iizumi T, Okumura T, and Sakurai H

Abstract

Desmoid tumors are benign, but may have a locally invasive tendency that commonly results in local recurrence. Most occur on the body trunk or extremities, whereas a head and neck desmoid tumor is relatively rare. The efficacy of radiotherapy has been suggested and 50-60 Gy is used for unresectable or recurrent desmoid tumors, but there are few reports of use of particle beam therapy. However, since this tumor occurs more often in younger patients compared to malignant tumors and the prognosis is favorable, there may be an advantage of this therapy. We treated a male patient with a head and neck recurrent desmoid tumor with proton beam therapy (PBT) at a dose of 60 Gy (RBE). This patient underwent surgical resection as initial treatment, but the tumor recurred only six months after surgery, and resection was performed again. After PBT, the tumor gradually shrank and complete remission has been achieved for 10 years without any severe late toxicity. Here, we report the details of this case, with a review of the literature. We suggest that PBT may reduce the incidence of second malignant tumors by reducing the dose exposure around the planning target volume., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could appear to influence the work reported in this paper., (© 2020 Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.)

Published
2020
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