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73. UV Light and MSH Receptors

Author

CHAKRABORTY, ASHOK K., FUNASAKA, YOKO, SLOMINSKI, ANDRZEJ, BOLOGNIA, JEAN, SODI, STEFANO, ICHIHASHI, MASAMITSU, and PAWELEK, JOHN M.

Published
1999

90. bcl-2 expression in epidermal keratinocytic diseases

Author

Nakagawa, Kowichi, Yamamura, Keizo, Maeda, Sakan, and Ichihashi, Masamitsu

Subjects
Keratinocytes -- Abnormalities, Skin tumors -- Physiological aspects, Health
Abstract

Background. The bcl-2 protein has been shown to suppress apoptosis, and overexpression of the bcl-2 protein has been reported in several malignant tumors. Skin is one of the largest organs in the body, and the most common human malignancies arise from keratinocytes in the epidermis. In this paper, the authors analyzed immunohistochemically the expression of the bcl-2 protein in several keratinocytic (KC) tumors and inflammatory skin disorders to investigate the role of bcl-2 in the development of benign and malignant skin tumors. Methods. Seventy-two frozen tissues from patients with inflammatory KC proliferation (chronic dermatitis [CD] and psoriasis vulgaris [PV]), seborrheic keratosis (SK), carcinoma in situ of KC tumors (actinic keratosis [AK] and Bowen's disease [BD]), basal cell carcinoma (BCC), and squamous cell carcinoma (SCC), 2 SCC cell lines, and 20 normal skin were immunostained with an anti-bcl-2 monoclonal antibody. Results. Tissue with normal KC, CD, PV, and SK scarcely expressed the bcl-2 protein. Seventy-three percent of tissue with BD, 25% with AK, 67% with BCC, and 100% with SCC showed obvious bcl-2 protein expression. bcl-2 expression of BCC, BD, and SCC was restricted to the involved lesions, and surrounding normal tissue with KCs were bcl-2 negative. Interestingly, tissue with atrophic AK expressed no bcl-2 protein (none of five cases), whereas tissue with hypertrophic AK reacted weakly with the anti-bcl-2 antibody (two of three cases). Conclusions. bcl-2 protein expression in patients with KC may be related to tumorigenic proliferation possibly due to enhanced cell survival, but not when inflammatory proliferation of keratinocytes is present. Cancer 1994; 74:1720-4.

Published
1994

92. Malignant schwannoma associated with xeroderma pigmentosum in a patient belonging to complementation group D

Author

Nakamura, Takehiko, Ono, Tomomichi, Yoshimura, Koji, Arao, Tatsuyoshi, Kondo, Seiji, Ichihashi, Masamitsu, Matsumoto, Akira, and Fujiwara, Yoshisada

Subjects
Nervous system tumors -- Case studies, Brain tumors -- Case studies, Xeroderma pigmentosum -- Case studies, Health
Abstract

Xeroderma pigmentosum is a rare skin disorder characterized by widespread pigment abnormalities, ulcers, and wasting away of skin and muscle tissue. There are various forms of xeroderma pigmentosum, which may be distinguished by the presence of abnormalities of the brain and spine, and by the age at which these nerve-related disorders develop. One study showed that the incidence of nervous tissue tumors is increased in patients with xeroderma pigmentosum. A case is described of a 43-year-old man with mild symptoms of xeroderma pigmentosum, a malignant freckle on the right cheek, and a tumor in the left cheek. The patient's parents were second cousins. The patient was photosensitive (unusually sensitive to light) at age one year, and developed freckles at age six, but did not have a history of nerve-related disorders. At age 43 years, the patient developed abnormal sensations in the left upper lip after a tooth extraction, and pain along the trigeminal nerve, which innervates the face; this was probably due to the tumor in his left cheek. The patient's fibroblasts, cells from which connective tissue develops, had increased sensitivity to ultraviolet radiation and diminished production of DNA. Further examination of the brain revealed a tumor of the trigeminal nerve, which originated in a portion of the brain and extended to the left cheek. The tumor was removed by surgery. The tumor was diagnosed as a malignant schwannoma, or tumor of the Schwann sheath, which is the thin membrane surrounding a nerve fiber. This is the first reported case of malignant schwannoma associated with xeroderma pigmentosum. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

98. Preface

Author

Ando, Hideya, primary, Ichihashi, Masamitsu, additional, and Morita, Akimichi, additional

Published
2019
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