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51. Early impairment in mitochondrial quality check and function precedes the development of cardiac phenotypes in an mouse model of Fabry Disease

Author

Gambardella, Jessica, Fiordelisi, Antonella, Cerasuolo, Federica Andrea, Buonaiuto, Antonietta, Avvisato, Roberta, Viti, Alessandro, Sommella, Eduardo, Campiglia, Pietro, D'Argenio, Valeria, Prevete, Nella, D'Apice, Stefania, Varzideh, Fahimeh, Paolillo, Roberta, Perrino, Cinzia, Riccio, Eleonora, Pisani, Antonio, Bianco, Antonio, Sadoshima, Junichi, Spinelli, Letizia, Santulli, Gaetano, Sorriento, Daniela, and Iaccarino, Guido

Published
2024
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52. Macrophages participate in doxorubicin-induced cardiac damage

Author

Cerasuolo, Federica Andrea, Gambardella, Jessica, Santulli, Gaetano, Fiordelisi, Antonella, Wang, Xujun, Prevete, Nella, Sommella, Edoardo, Avvisato, Roberta, Buonaiuto, Antonietta, Altobelli, Giovanna Giuseppina, Ciccarelli, Michele, Morisco, Carmine, Sadoshima, Junichi, Iaccarino, Guido, and Sorriento, Daniela

Published
2024
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56. Functional Role of Mitochondria in Arrhythmogenesis

Author

Gambardella, Jessica, Sorriento, Daniela, Ciccarelli, Michele, Del Giudice, Carmine, Fiordelisi, Antonella, Napolitano, Luigi, Trimarco, Bruno, Iaccarino, Guido, Santulli, Gaetano, COHEN, IRUN R., Series editor, LAJTHA, ABEL, Series editor, LAMBRIS, JOHN D., Series editor, PAOLETTI, RODOLFO, Series editor, and Santulli, Gaetano, editor

Published
2017
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57. Prognostic Implications of the Extent of Cardiac Damage in Patients With Fabry Disease

Author

Meucci, Maria Chiara, primary, Lillo, Rosa, additional, Del Franco, Annamaria, additional, Monda, Emanuele, additional, Iannaccone, Giulia, additional, Baldassarre, Riccardo, additional, Di Nicola, Federico, additional, Parisi, Vanda, additional, Lombardo, Antonella, additional, Spinelli, Letizia, additional, Biagini, Elena, additional, Pieroni, Maurizio, additional, Pisani, Antonio, additional, Crea, Filippo, additional, Iaccarino, Guido, additional, Limongelli, Giuseppe, additional, Olivotto, Iacopo, additional, and Graziani, Francesca, additional

Published
2023
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62. Serum uric acid, predicts heart failure in a large Italian cohort: search for a cut-off value the URic acid Right for heArt Health study

Author

Muiesan, Maria L., Salvetti, Massimo, Virdis, Agostino, Masi, Stefano, Casiglia, Edoardo, Tikhonoff, Valérie, Barbagallo, Carlo M., Bombelli, Michele, Cicero, Arrigo F.G., Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D’Eliak, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Mallamaci, Francesca, Maloberti, Alessandro, Mazza, Alberto, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Rattazzi, Marcello, Rivasi, Giulia, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Grassi, Guido, and Borghi, Claudio

Published
2021
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64. Diet and Physical Activity in Fabry Disease: A Narrative Review.

Author

Muscogiuri, Giovanna, De Marco, Oriana, Di Lorenzo, Tonia, Amicone, Maria, Capuano, Ivana, Riccio, Eleonora, Iaccarino, Guido, Bianco, Antonio, Di Risi, Teodolinda, and Pisani, Antonio

Abstract

Fabry disease (FD) is caused by mutations in the galactosidase alpha (GLA) gene which lead to the accumulation of globotriaosylceramide (Gb-3). Enzyme replacement therapy (ERT) and oral chaperone therapy are the current pharmacological treatments for this condition. However, in the literature, there is a growing emphasis on exploring non-pharmacological therapeutic strategies to improve the quality of life of patients with FD. In particular, the nutritional approach to FD has been marginally addressed in the scientific literature, although specific dietary interventions may be useful for the management of nephropathy and gastrointestinal complications, which are often present in patients with FD. Especially in cases of confirmed diagnosis of irritable bowel syndrome (IBS), a low-FODMAP diet can represent an effective approach to improving intestinal manifestations. Furthermore, it is known that some food components, such as polyphenols, may be able to modulate some pathogenetic mechanisms underlying the disease, such as inflammation and oxidative stress. Therefore, the use of healthy dietary patterns should be encouraged in this patient group. Sports practice can be useful for patients with multi-organ involvement, particularly in cardiovascular, renal, and neurological aspects. Therefore, the aim of this review is to summarize current knowledge on the role of nutrition and physical activity in FD patients. [ABSTRACT FROM AUTHOR]

Published
2024
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65. Role of Endothelial G Protein-Coupled Receptor Kinase 2 in Angioedema

Author

Gambardella, Jessica, Sorriento, Daniela, Bova, Maria, Rusciano, Mariarosaria, Loffredo, Stefania, Wang, Xujun, Petraroli, Angelica, Carucci, Laura, Mormile, Ilaria, Oliveti, Marco, Bruno Morelli, Marco, Fiordelisi, Antonella, Spadaro, Giuseppe, Campiglia, Pietro, Sala, Marina, Trimarco, Bruno, Iaccarino, Guido, Santulli, Gaetano, and Ciccarelli, Michele

Published
2020
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66. Serum uric acid and fatal myocardial infarction: detection of prognostic cut-off values: The URRAH (Uric Acid Right for Heart Health) study

Author

Casiglia, Edoardo, Tikhonoff, Valérie, Virdis, Agostino, Masi, Stefano, Barbagallo, Carlo M., Bombelli, Michele, Bruno, Bernardino, Cicero, Arrigo F.G., Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D’Elia, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Rivasi, Giulia, Salvetti, Massimo, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Grassi, Guido, and Borghi, Claudio

Published
2020
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68. Cellular subtype expression and activation of CaMKII regulate the fate of atherosclerotic plaque

Author

Maione, Angela Serena, Cipolletta, Ersilia, Sorriento, Daniela, Borriello, Francesco, Soprano, Maria, Rusciano, Maria Rosaria, D'Esposito, Vittoria, Markabaoui, Abdul Karim, De Palma, Giovanni Domenico, Martino, Giovanni, Maresca, Lucio, Nobile, Giuseppe, Campiglia, Pietro, Formisano, Pietro, Ciccarelli, Michele, Marone, Gianni, Trimarco, Bruno, Iaccarino, Guido, and Illario, Maddalena

Published
2017
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71. Clinical outcomes of a digitally supported approach for self-management of type 2 diabetes mellitus

Author

De Luca, Vincenzo, primary, Bozzetto, Lutgarda, additional, Giglio, Clemente, additional, Tramontano, Giovanni, additional, De Simone, Giuseppina, additional, Luciano, Antonio, additional, Lucibelli, Luigi, additional, Maffettone, Ada, additional, Riccio, Michele, additional, Romano, Geremia, additional, Rossi, Ernesto, additional, Chiatti, Carlos Juan, additional, Berler, Alexander, additional, Iaccarino, Guido, additional, Illario, Maddalena, additional, and Annuzzi, Giovanni, additional

Published
2023
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73. PROGNOSTIC VALUE AND RELATIVE CUT-OFFS OF TRIGLYCERIDES PREDICTING CARDIOVASCULAR OUTCOME IN A LARGE REGIONAL-BASED ITALIAN DATABASE

Author

Tikhonoff, Valérie, primary, Casiglia, Edoardo, additional, Virdis, Agostino, additional, Grassi, Guido, additional, Angeli, Fabio, additional, Arca, Marcello, additional, Barbagallo, Carlo M., additional, Bombelli, Michele, additional, Cappelli, Federica, additional, Cianci, Rosario, additional, Cicero, Arrigo FG, additional, Cirillo, Massimo, additional, Cirillo, Pietro, additional, Dell’oro, Raffaella, additional, D’elia, Lanfranco, additional, Desideri, Giovambattista, additional, Ferri, Claudio, additional, Galletti, Ferruccio, additional, Gesualdo, Loreto, additional, Giannattasio, Cristina, additional, Iaccarino, Guido, additional, Mallamaci, Francesca, additional, Maloberti, Alessandro, additional, Masi, Stefano, additional, Masulli, Maria, additional, Mazza, Alberto, additional, Mengozzi, Alessandro, additional, Muiesan, Maria Lorenza, additional, Nazzaro, Pietro, additional, Palatini, Paolo, additional, Parati, Gianfranco, additional, Pontremoli, Roberto, additional, Quarti-Trevano, Fosca, additional, Rattazzi, Marcello, additional, Reboldi, Gianpaolo, additional, Rivasi, Giulia, additional, Russo, Elisa, additional, Salvetti, Massimo, additional, Temporelli, Pier Luigi, additional, Tocci, Giuliano, additional, Ungar, Andrea, additional, Verdecchia, Paolo, additional, Viazzi, Francesca, additional, Volpe, Massimo, additional, and Borghi, Claudio, additional

Published
2023
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76. Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases

Author

Bousquet, J. Jean, Schünemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenço, Olga M., Menditto, Enrica, Mullol, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhân, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bialek, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D’Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioğlu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, González Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzmán, Maria-Antonieta, Hajjam, Jawad, O’B Hourihane, John, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Illario, Maddalena, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, De Manuel Keenoy, Esteban, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melén, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralf, Münter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonné, O’Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schöll, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pépin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Picard, Robert, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Söderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimäki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Solé, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Suppli Ulrik, Charlotte, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter V., Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frédéric, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stéphane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., Zidarn, Mihaela, the ARIA Study Group, and the MASK Study Group

Published
2019
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78. Telemedicine and Digital Medicine in the Clinical Management of Hypertension and Hypertension-Related Cardiovascular Diseases: A Position Paper of the Italian Society of Arterial Hypertension (SIIA)

Author

Minuz, P, Albini, F, Imbalzano, E, Izzo, R, Masi, S, Pengo, M, Pucci, G, Scalise, F, Salvetti, M, Tocci, G, Cicero, A, Iaccarino, G, Savoia, C, Sechi, L, Parati, G, Borghi, C, Volpe, M, Ferri, C, Grassi, G, Muiesan, M, Minuz, Pietro, Albini, Fabio Lucio, Imbalzano, Egidio, Izzo, Raffaele, Masi, Stefano, Pengo, Martino F, Pucci, Giacomo, Scalise, Filippo, Salvetti, Massimo, Tocci, Giuliano, Cicero, Arrigo, Iaccarino, Guido, Savoia, Carmine, Sechi, Leonardo, Parati, Gianfranco, Borghi, Claudio, Volpe, Massimo, Ferri, Claudio, Grassi, Guido, Muiesan, Maria Lorenza, Minuz, P, Albini, F, Imbalzano, E, Izzo, R, Masi, S, Pengo, M, Pucci, G, Scalise, F, Salvetti, M, Tocci, G, Cicero, A, Iaccarino, G, Savoia, C, Sechi, L, Parati, G, Borghi, C, Volpe, M, Ferri, C, Grassi, G, Muiesan, M, Minuz, Pietro, Albini, Fabio Lucio, Imbalzano, Egidio, Izzo, Raffaele, Masi, Stefano, Pengo, Martino F, Pucci, Giacomo, Scalise, Filippo, Salvetti, Massimo, Tocci, Giuliano, Cicero, Arrigo, Iaccarino, Guido, Savoia, Carmine, Sechi, Leonardo, Parati, Gianfranco, Borghi, Claudio, Volpe, Massimo, Ferri, Claudio, Grassi, Guido, and Muiesan, Maria Lorenza

Abstract

High blood pressure is the leading cause of death and disability globally and an important treatable risk factor for cardiovascular, cerebrovascular and chronic kidney diseases. Digital technology, including mobile health solutions and digital therapy, is expanding rapidly in clinical medicine and has the potential to improve the quality of care and effectiveness of drug treatment by making medical interventions timely, tailored to hypertensive patients' needs and by improving treatment adherence. Thus, the systematic application of digital technologies could support diagnosis and awareness of hypertension and its complications, ultimately leading to improved BP control at the population level. The progressive implementation of digital medicine in the national health systems must be accompanied by the supervision and guidance of health authorities and scientific societies to ensure the correct use of these new technologies with consequent maximization of the potential benefits. The role of scientific societies in relation to the rapid adoption of digital technologies, therefore, should encompass the entire spectrum of activities pertaining to their institutional role: information, training, promotion of research, scientific collaboration and advice, evaluation and validation of technological tools, and collaboration with regulatory and health authorities.

Published
2023

79. The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation

Author

Maloberti, A, Mengozzi, A, Russo, E, Cicero, A, Angeli, F, Agabiti Rosei, E, Barbagallo, C, Bernardino, B, Bombelli, M, Cappelli, F, Casiglia, E, Cianci, R, Ciccarelli, M, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Dell'Oro, R, Facchetti, R, Ferri, C, Galletti, F, Giannattasio, C, Gesualdo, L, Iaccarino, G, Lippa, L, Mallamaci, F, Masi, S, Masulli, M, Mazza, A, Muiesan, M, Nazzaro, P, Parati, G, Palatini, P, Pauletto, P, Pontremoli, R, Pugliese, N, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Virdis, A, Grassi, G, Borghi, C, Maloberti, Alessandro, Mengozzi, Alessandro, Russo, Elisa, Cicero, Arrigo Francesco Giuseppe, Angeli, Fabio, Agabiti Rosei, Enrico, Barbagallo, Carlo Maria, Bernardino, Bruno, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo, Cianci, Rosario, Ciccarelli, Michele, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D'Elia, Lanfranco, Dell'Oro, Raffaella, Facchetti, Rita, Ferri, Claudio, Galletti, Ferruccio, Giannattasio, Cristina, Gesualdo, Loreto, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Parati, Gianfranco, Palatini, Paolo, Pauletto, Paolo, Pontremoli, Roberto, Pugliese, Nicola Riccardo, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Virdis, Agostino, Grassi, Guido, Borghi, Claudio, Maloberti, A, Mengozzi, A, Russo, E, Cicero, A, Angeli, F, Agabiti Rosei, E, Barbagallo, C, Bernardino, B, Bombelli, M, Cappelli, F, Casiglia, E, Cianci, R, Ciccarelli, M, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Dell'Oro, R, Facchetti, R, Ferri, C, Galletti, F, Giannattasio, C, Gesualdo, L, Iaccarino, G, Lippa, L, Mallamaci, F, Masi, S, Masulli, M, Mazza, A, Muiesan, M, Nazzaro, P, Parati, G, Palatini, P, Pauletto, P, Pontremoli, R, Pugliese, N, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Virdis, A, Grassi, G, Borghi, C, Maloberti, Alessandro, Mengozzi, Alessandro, Russo, Elisa, Cicero, Arrigo Francesco Giuseppe, Angeli, Fabio, Agabiti Rosei, Enrico, Barbagallo, Carlo Maria, Bernardino, Bruno, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo, Cianci, Rosario, Ciccarelli, Michele, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D'Elia, Lanfranco, Dell'Oro, Raffaella, Facchetti, Rita, Ferri, Claudio, Galletti, Ferruccio, Giannattasio, Cristina, Gesualdo, Loreto, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Parati, Gianfranco, Palatini, Paolo, Pauletto, Paolo, Pontremoli, Roberto, Pugliese, Nicola Riccardo, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Virdis, Agostino, Grassi, Guido, and Borghi, Claudio

Abstract

The relationship between Serum Uric Acid (UA) and Cardiovascular (CV) diseases has already been extensively evaluated, and it was found to be an independent predictor of all-cause and cardiovascular mortality but also acute coronary syndrome, stroke and heart failure. Similarly, also many papers have been published on the association between UA and kidney function, while less is known on the role of UA in metabolic derangement and, particularly, in metabolic syndrome. Despite the substantial number of publications on the topic, there are still some elements of doubt: (1) the better cut-off to be used to refine CV risk (also called CV cut-off); (2) the needing for a correction of UA values for kidney function; and (3) the better definition of its role in metabolic syndrome: is UA simply a marker, a bystander or a key pathological element of metabolic dysregulation?. The Uric acid Right for heArt Health (URRAH) project was designed by the Working Group on uric acid and CV risk of the Italian Society of Hypertension to answer the first question. After the first papers that individuates specific cut-off for different CV disease, subsequent articles have been published responding to the other relevant questions. This review will summarise most of the results obtained so far from the URRAH research project.

Published
2023

80. Serum Uric Acid Predicts All-Cause and Cardiovascular Mortality Independently of Hypertriglyceridemia in Cardiometabolic Patients without Established CV Disease: A Sub-Analysis of the URic acid Right for heArt Health (URRAH) Study

Author

Mengozzi, A, Pugliese, N, Desideri, G, Masi, S, Angeli, F, Barbagallo, C, Bombelli, M, Cappelli, F, Casiglia, E, Cianci, R, Ciccarelli, M, Cicero, A, Cirillo, M, Cirillo, P, Dell’Oro, R, D’Elia, L, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Grassi, G, Iaccarino, G, Lippa, L, Mallamaci, F, Maloberti, A, Masulli, M, Mazza, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Russo, E, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Virdis, A, Mengozzi, Alessandro, Pugliese, Nicola Riccardo, Desideri, Giovambattista, Masi, Stefano, Angeli, Fabio, Barbagallo, Carlo Maria, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo, Cianci, Rosario, Ciccarelli, Michele, Cicero, Arrigo F. G., Cirillo, Massimo, Cirillo, Pietro, Dell’Oro, Raffaella, D’Elia, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Borghi, Claudio, Virdis, Agostino, Mengozzi, A, Pugliese, N, Desideri, G, Masi, S, Angeli, F, Barbagallo, C, Bombelli, M, Cappelli, F, Casiglia, E, Cianci, R, Ciccarelli, M, Cicero, A, Cirillo, M, Cirillo, P, Dell’Oro, R, D’Elia, L, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Grassi, G, Iaccarino, G, Lippa, L, Mallamaci, F, Maloberti, A, Masulli, M, Mazza, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Russo, E, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Virdis, A, Mengozzi, Alessandro, Pugliese, Nicola Riccardo, Desideri, Giovambattista, Masi, Stefano, Angeli, Fabio, Barbagallo, Carlo Maria, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo, Cianci, Rosario, Ciccarelli, Michele, Cicero, Arrigo F. G., Cirillo, Massimo, Cirillo, Pietro, Dell’Oro, Raffaella, D’Elia, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Borghi, Claudio, and Virdis, Agostino

Abstract

High serum uric acid (SUA) and triglyceride (TG) levels might promote high-cardiovascular risk phenotypes across the cardiometabolic spectrum. However, SUA predictive power in the presence of normal and high TG levels has never been investigated. We included 8124 patients from the URic acid Right for heArt Health (URRAH) study cohort who were followed for over 20 years and had no established cardiovascular disease or uncontrolled metabolic disease. All-cause mortality (ACM) and cardiovascular mortality (CVM) were explored by the Kaplan–Meier estimator and Cox multivariable regression, adopting recently defined SUA cut-offs for ACM (≥4.7 mg/dL) and CVM (≥5.6 mg/dL). Exploratory analysis across cardiometabolic subgroups and a sensitivity analysis using SUA/serum creatinine were performed as validation. SUA predicted ACM (HR 1.25 [1.12–1.40], p < 0.001) and CVM (1.31 [1.11–1.74], p < 0.001) in the whole study population, and according to TG strata: ACM in normotriglyceridemia (HR 1.26 [1.12–1.43], p < 0.001) and hypertriglyceridemia (1.31 [1.02–1.68], p = 0.033), and CVM in normotriglyceridemia (HR 1.46 [1.23–1.73], p < 0.001) and hypertriglyceridemia (HR 1.31 [0.99–1.64], p = 0.060). Exploratory and sensitivity analyses confirmed our findings, suggesting a substantial role of SUA in normotriglyceridemia and hypertriglyceridemia. In conclusion, we report that SUA can predict ACM and CVM in cardiometabolic patients without established cardiovascular disease, independent of TG levels.

Published
2023

81. Hyperuricemia increases the risk of cardiovascular mortality associated with very high HdL-cholesterol level

Author

Palatini, P, Virdis, A, Masi, S, Mengozzi, A, Casiglia, E, Tikhonoff, V, Cicero, A, Ungar, A, Parati, G, Rivasi, G, Salvetti, M, Barbagallo, C, Bombelli, M, Dell'Oro, R, Bruno, B, Lippa, L, D'Elia, L, Masulli, M, Verdecchia, P, Reboldi, G, Angeli, F, Mallamaci, F, Cirillo, M, Rattazzi, M, Cirillo, P, Gesualdo, L, Mazza, A, Giannattasio, C, Maloberti, A, Volpe, M, Tocci, G, Iaccarino, G, Nazzaro, P, Galletti, F, Ferri, C, Desideri, G, Viazzi, F, Pontremoli, R, Muiesan, M, Grassi, G, Borghi, C, Palatini, Paolo, Virdis, Agostino, Masi, Stefano, Mengozzi, Alessandro, Casiglia, Edoardo, Tikhonoff, Valerie, Cicero, Arrigo F G, Ungar, Andrea, Parati, Gianfranco, Rivasi, Giulia, Salvetti, Massimo, Barbagallo, Carlo M, Bombelli, Michele, Dell'Oro, Raffaella, Bruno, Berardino, Lippa, Luciano, D'Elia, Lanfranco, Masulli, Maria, Verdecchia, Paolo, Reboldi, Gianpaolo, Angeli, Fabio, Mallamaci, Francesca, Cirillo, Massimo, Rattazzi, Marcello, Cirillo, Pietro, Gesualdo, Loreto, Mazza, Alberto, Giannattasio, Cristina, Maloberti, Alessandro, Volpe, Massimo, Tocci, Giuliano, Iaccarino, Guido, Nazzaro, Pietro, Galletti, Ferruccio, Ferri, Claudio, Desideri, Giovambattista, Viazzi, Francesca, Pontremoli, Roberto, Muiesan, Maria Lorenza, Grassi, Guido, Borghi, Claudio, Palatini, P, Virdis, A, Masi, S, Mengozzi, A, Casiglia, E, Tikhonoff, V, Cicero, A, Ungar, A, Parati, G, Rivasi, G, Salvetti, M, Barbagallo, C, Bombelli, M, Dell'Oro, R, Bruno, B, Lippa, L, D'Elia, L, Masulli, M, Verdecchia, P, Reboldi, G, Angeli, F, Mallamaci, F, Cirillo, M, Rattazzi, M, Cirillo, P, Gesualdo, L, Mazza, A, Giannattasio, C, Maloberti, A, Volpe, M, Tocci, G, Iaccarino, G, Nazzaro, P, Galletti, F, Ferri, C, Desideri, G, Viazzi, F, Pontremoli, R, Muiesan, M, Grassi, G, Borghi, C, Palatini, Paolo, Virdis, Agostino, Masi, Stefano, Mengozzi, Alessandro, Casiglia, Edoardo, Tikhonoff, Valerie, Cicero, Arrigo F G, Ungar, Andrea, Parati, Gianfranco, Rivasi, Giulia, Salvetti, Massimo, Barbagallo, Carlo M, Bombelli, Michele, Dell'Oro, Raffaella, Bruno, Berardino, Lippa, Luciano, D'Elia, Lanfranco, Masulli, Maria, Verdecchia, Paolo, Reboldi, Gianpaolo, Angeli, Fabio, Mallamaci, Francesca, Cirillo, Massimo, Rattazzi, Marcello, Cirillo, Pietro, Gesualdo, Loreto, Mazza, Alberto, Giannattasio, Cristina, Maloberti, Alessandro, Volpe, Massimo, Tocci, Giuliano, Iaccarino, Guido, Nazzaro, Pietro, Galletti, Ferruccio, Ferri, Claudio, Desideri, Giovambattista, Viazzi, Francesca, Pontremoli, Roberto, Muiesan, Maria Lorenza, Grassi, Guido, and Borghi, Claudio

Abstract

Background and aims: Whether the association between very high HDL-cholesterol levels and cardiovascular mortality (CVM) is modulated by some facilitating factors is unclear. Aim of the study was to investigate whether the risk of CVM associated with very high HDL-cholesterol is increased in subjects with hyperuricemia. Methods and results: Multivariable Cox analyses were made in 18,072 participants from the multicentre URRAH study stratified by sex and HDL-cholesterol category. During a median follow-up of 11.4 years there were 1307 cases of CVM. In multivariable Cox models a J-shaped association was found in the whole population, with the highest risk being present in the high HDL-cholesterol group [>80 mg/dL, adjusted hazard ratio (HR), 1.28; 95%CI, 1.02–1.61; p = 0.031)]. However, a sex-specific analysis revealed that this association was present only in women (HR, 1.34; 95%CI, 1.02–1.77; p = 0.034) but not in men. The risk of CVM related to high HDL-cholesterol was much greater in the women with high uric acid (>0.30 mmol/L, HR 1.61; 95%CI, 1.08–2.39) than in those with low uric acid (HR, 1.17; 95%CI, 0.80–1.72, p for interaction = 0.016). In women older than 70 years with hyperuricemia the risk related to high HDL-cholesterol was 1.83 (95%CI, 1.19–2.80, p < 0.005). Inclusion of BMI in the models weakened the strength of the associations. Conclusion: Our data indicate that very high HDL-cholesterol levels in women are associated with CVM in a J-shaped fashion. The risk of CVM is increased by concomitant hyperuricemia suggesting that a proinflammatory/oxidative state can enhance the detrimental cardiovascular effects associated with high HDL-cholesterol.

Published
2023

82. Serum uric acid / serum creatinine ratio as a predictor of cardiovascular events. Detection of prognostic cardiovascular cut-off values

Author

Casiglia, E, Tikhonoff, V, Virdis, A, Grassi, G, Angeli, F, Barbagallo, C, Bombelli, M, Cicero, A, Cirillo, M, Cirillo, P, Dell'Oro, R, D'Elia, L, Desideri, G, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Lippa, L, Mallamaci, F, Masi, S, Maloberti, A, Masulli, M, Mazza, A, Mengozzi, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Salvetti, M, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Casiglia, Edoardo, Tikhonoff, Valérie, Virdis, Agostino, Grassi, Guido, Angeli, Fabio, Barbagallo, Carlo M, Bombelli, Michele, Cicero, Arrigo F G, Cirillo, Massimo, Cirillo, Pietro, Dell'Oro, Raffaella, D'elia, Lanfranco, Desideri, Giovambattista, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Maloberti, Alessandro, Masulli, Maria, Mazza, Alberto, Mengozzi, Alessandro, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Salvetti, Massimo, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Borghi, Claudio, Casiglia, E, Tikhonoff, V, Virdis, A, Grassi, G, Angeli, F, Barbagallo, C, Bombelli, M, Cicero, A, Cirillo, M, Cirillo, P, Dell'Oro, R, D'Elia, L, Desideri, G, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Lippa, L, Mallamaci, F, Masi, S, Maloberti, A, Masulli, M, Mazza, A, Mengozzi, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Salvetti, M, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Casiglia, Edoardo, Tikhonoff, Valérie, Virdis, Agostino, Grassi, Guido, Angeli, Fabio, Barbagallo, Carlo M, Bombelli, Michele, Cicero, Arrigo F G, Cirillo, Massimo, Cirillo, Pietro, Dell'Oro, Raffaella, D'elia, Lanfranco, Desideri, Giovambattista, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Maloberti, Alessandro, Masulli, Maria, Mazza, Alberto, Mengozzi, Alessandro, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Salvetti, Massimo, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, and Borghi, Claudio

Abstract

Objective:In the frame of the Uric Acid Right for Heart Health (URRAH) study, a nationwide multicenter study involving adult participants recruited on a regional community basis from all the territory of Italy under the patronage of the Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension, we searched for the cut-off values of the ratio between serum uric acid (SUA) and serum creatinine (sCr) able to predict cardiovascular (CV) events.Methods:Among 20 724 participants followed-up for 126 ± 64 months, after detecting cut-off by the receiver operating characteristic curves, we calculated by Cox models adjusted for confounders having CV events as dependent variable the hazard ratio (HR) of SUA/sCr > cut-off. We also verified if the role of cut-off varied with increasing SUA/sCr.Results:A plausible prognostic cut-off of SUA/sCr was found and was the same in the whole database, in men and in women (>5.35). The HR of SUA/sCr > cut-off was 1.159 (95% confidence interval [CI] 1.092-1.131, P < 0.03) in all, 1.161 (95% CI 1.021-1.335, P < 0.02) in men, and 1.444 (95% CI 1.012-1.113, P < 0.03) in women. In increasing quintiles of SUA/sCr the cut-offs were >3.08, >4.87, >5.35, >6.22 and >7.58, respectively. The HRs significantly increased from the 3rd to the 5th quintile (1.21, 95% CI 1.032-1.467, P = 0.018; 1.294, 95% CI 1.101-1.521, P = 0.002; and 1.642, 95% CI 1.405-1.919, P < 0.0001; respectively), that is, over 5.35, whereas the 2nd quintile was not significantly different from the 1st (reference).Conclusion:Having SUA/sCr >5.35 is an independent CV risk indicator both in men and women. The cut-off is dynamic and significantly increases with increasing SUA/sCr.

Published
2023

83. The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation

Author

Maloberti, Alessandro; https://orcid.org/0000-0002-2612-6264, Mengozzi, Alessandro; https://orcid.org/0000-0003-2834-9725, Russo, Elisa, Cicero, Arrigo Francesco Giuseppe; https://orcid.org/0000-0002-4367-3884, Angeli, Fabio; https://orcid.org/0000-0003-4925-7985, Agabiti Rosei, Enrico, Barbagallo, Carlo Maria; https://orcid.org/0000-0002-4114-038X, Bernardino, Bruno, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo; https://orcid.org/0000-0002-0003-3289, Cianci, Rosario, Ciccarelli, Michele; https://orcid.org/0000-0003-2379-1960, Cirillo, Massimo; https://orcid.org/0000-0002-6409-3504, Cirillo, Pietro, Desideri, Giovambattista; https://orcid.org/0000-0002-0145-1271, D'Elia, Lanfranco; https://orcid.org/0000-0002-1782-0211, Dell'Oro, Raffaella, Facchetti, Rita, Ferri, Claudio, Galletti, Ferruccio, Giannattasio, Cristina, Gesualdo, Loreto; https://orcid.org/0000-0002-4861-0911, Iaccarino, Guido, Lippa, Luciano; https://orcid.org/0000-0003-1249-3861, Mallamaci, Francesca, Masi, Stefano; https://orcid.org/0000-0002-7591-3686, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza; https://orcid.org/0000-0002-4007-9441, et al, Maloberti, Alessandro; https://orcid.org/0000-0002-2612-6264, Mengozzi, Alessandro; https://orcid.org/0000-0003-2834-9725, Russo, Elisa, Cicero, Arrigo Francesco Giuseppe; https://orcid.org/0000-0002-4367-3884, Angeli, Fabio; https://orcid.org/0000-0003-4925-7985, Agabiti Rosei, Enrico, Barbagallo, Carlo Maria; https://orcid.org/0000-0002-4114-038X, Bernardino, Bruno, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo; https://orcid.org/0000-0002-0003-3289, Cianci, Rosario, Ciccarelli, Michele; https://orcid.org/0000-0003-2379-1960, Cirillo, Massimo; https://orcid.org/0000-0002-6409-3504, Cirillo, Pietro, Desideri, Giovambattista; https://orcid.org/0000-0002-0145-1271, D'Elia, Lanfranco; https://orcid.org/0000-0002-1782-0211, Dell'Oro, Raffaella, Facchetti, Rita, Ferri, Claudio, Galletti, Ferruccio, Giannattasio, Cristina, Gesualdo, Loreto; https://orcid.org/0000-0002-4861-0911, Iaccarino, Guido, Lippa, Luciano; https://orcid.org/0000-0003-1249-3861, Mallamaci, Francesca, Masi, Stefano; https://orcid.org/0000-0002-7591-3686, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza; https://orcid.org/0000-0002-4007-9441, and et al

Abstract

The relationship between Serum Uric Acid (UA) and Cardiovascular (CV) diseases has already been extensively evaluated, and it was found to be an independent predictor of all-cause and cardiovascular mortality but also acute coronary syndrome, stroke and heart failure. Similarly, also many papers have been published on the association between UA and kidney function, while less is known on the role of UA in metabolic derangement and, particularly, in metabolic syndrome. Despite the substantial number of publications on the topic, there are still some elements of doubt: (1) the better cut-off to be used to refine CV risk (also called CV cut-off); (2) the needing for a correction of UA values for kidney function; and (3) the better definition of its role in metabolic syndrome: is UA simply a marker, a bystander or a key pathological element of metabolic dysregulation?. The Uric acid Right for heArt Health (URRAH) project was designed by the Working Group on uric acid and CV risk of the Italian Society of Hypertension to answer the first question. After the first papers that individuates specific cut-off for different CV disease, subsequent articles have been published responding to the other relevant questions. This review will summarise most of the results obtained so far from the URRAH research project.

Published
2023

84. Serum Uric Acid Predicts All-Cause and Cardiovascular Mortality Independently of Hypertriglyceridemia in Cardiometabolic Patients without Established CV Disease: A Sub-Analysis of the URic acid Right for heArt Health (URRAH) Study

Author

Mengozzi, Alessandro; https://orcid.org/0000-0003-2834-9725, Pugliese, Nicola Riccardo; https://orcid.org/0000-0002-5473-227X, Desideri, Giovambattista; https://orcid.org/0000-0002-0145-1271, Masi, Stefano; https://orcid.org/0000-0002-7591-3686, Angeli, Fabio; https://orcid.org/0000-0003-4925-7985, Barbagallo, Carlo Maria; https://orcid.org/0000-0002-4114-038X, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo; https://orcid.org/0000-0002-0003-3289, Cianci, Rosario, Ciccarelli, Michele; https://orcid.org/0000-0003-2379-1960, Cicero, Arrigo F G; https://orcid.org/0000-0002-4367-3884, Cirillo, Massimo; https://orcid.org/0000-0002-6409-3504, Cirillo, Pietro, Dell'Oro, Raffaella, D'Elia, Lanfranco; https://orcid.org/0000-0002-1782-0211, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto; https://orcid.org/0000-0002-4861-0911, Giannattasio, Cristina, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano; https://orcid.org/0000-0003-1249-3861, Mallamaci, Francesca, Maloberti, Alessandro; https://orcid.org/0000-0002-2612-6264, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza; https://orcid.org/0000-0002-4007-9441, Nazzaro, Pietro, Palatini, Paolo; https://orcid.org/0000-0001-5402-4946, et al, Mengozzi, Alessandro; https://orcid.org/0000-0003-2834-9725, Pugliese, Nicola Riccardo; https://orcid.org/0000-0002-5473-227X, Desideri, Giovambattista; https://orcid.org/0000-0002-0145-1271, Masi, Stefano; https://orcid.org/0000-0002-7591-3686, Angeli, Fabio; https://orcid.org/0000-0003-4925-7985, Barbagallo, Carlo Maria; https://orcid.org/0000-0002-4114-038X, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo; https://orcid.org/0000-0002-0003-3289, Cianci, Rosario, Ciccarelli, Michele; https://orcid.org/0000-0003-2379-1960, Cicero, Arrigo F G; https://orcid.org/0000-0002-4367-3884, Cirillo, Massimo; https://orcid.org/0000-0002-6409-3504, Cirillo, Pietro, Dell'Oro, Raffaella, D'Elia, Lanfranco; https://orcid.org/0000-0002-1782-0211, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto; https://orcid.org/0000-0002-4861-0911, Giannattasio, Cristina, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano; https://orcid.org/0000-0003-1249-3861, Mallamaci, Francesca, Maloberti, Alessandro; https://orcid.org/0000-0002-2612-6264, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza; https://orcid.org/0000-0002-4007-9441, Nazzaro, Pietro, Palatini, Paolo; https://orcid.org/0000-0001-5402-4946, and et al

Abstract

High serum uric acid (SUA) and triglyceride (TG) levels might promote high-cardiovascular risk phenotypes across the cardiometabolic spectrum. However, SUA predictive power in the presence of normal and high TG levels has never been investigated. We included 8124 patients from the URic acid Right for heArt Health (URRAH) study cohort who were followed for over 20 years and had no established cardiovascular disease or uncontrolled metabolic disease. All-cause mortality (ACM) and cardiovascular mortality (CVM) were explored by the Kaplan-Meier estimator and Cox multivariable regression, adopting recently defined SUA cut-offs for ACM (≥4.7 mg/dL) and CVM (≥5.6 mg/dL). Exploratory analysis across cardiometabolic subgroups and a sensitivity analysis using SUA/serum creatinine were performed as validation. SUA predicted ACM (HR 1.25 [1.12-1.40], p < 0.001) and CVM (1.31 [1.11-1.74], p < 0.001) in the whole study population, and according to TG strata: ACM in normotriglyceridemia (HR 1.26 [1.12-1.43], p < 0.001) and hypertriglyceridemia (1.31 [1.02-1.68], p = 0.033), and CVM in normotriglyceridemia (HR 1.46 [1.23-1.73], p < 0.001) and hypertriglyceridemia (HR 1.31 [0.99-1.64], p = 0.060). Exploratory and sensitivity analyses confirmed our findings, suggesting a substantial role of SUA in normotriglyceridemia and hypertriglyceridemia. In conclusion, we report that SUA can predict ACM and CVM in cardiometabolic patients without established cardiovascular disease, independent of TG levels.

Published
2023

85. Serum uric acid and left ventricular mass index independently predict cardiovascular mortality: The uric acid right for heart health (URRAH) project

Author

Muiesan, Maria Lorenza, Agabiti Rosei, Claudia, Paini, Anna, Casiglia, Edoardo, Cirillo, Massimo, Grassi, Guido, Iaccarino, Guido, Mallamaci, Francesca, Maloberti, Alessandro, Mazza, Alberto, Mengozzi, Alessandro, Palatini, Paolo, Parati, Gianfranco, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Borghi, Claudio, Working Group on Uric Acid and Cardiovascular Risk of the Italia, Muiesan, Maria Lorenza, Agabiti Rosei, Claudia, Paini, Anna, Casiglia, Edoardo, Cirillo, Massimo, Grassi, Guido, Iaccarino, Guido, Mallamaci, Francesca, Maloberti, Alessandro, Mazza, Alberto, Mengozzi, Alessandro, Palatini, Paolo, Parati, Gianfranco, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Borghi, Claudio, and Working Group on Uric Acid and Cardiovascular Risk of the Italia

Abstract

UNLABELLED A relationship between serum uric acid (SUA) and cardiovascular (CV) events has been documented in the Uric Acid Right for Heart Health (URRAH) study. AIM of this study was to investigate the association between SUA and left ventricular mass index (LVMI) and whether SUA and LVMI or their combination may predict the incidence of CV death. METHODS Subjects with echocardiographic measurement of LVMI included in the URRAH study (n=10733) were part of this analysis. LV hypertrophy (LVH) was defined as LVMI > 95 g/m2 in women and 115 g/m2 in men. RESULTS A significant association between SUA and LVMI was observed in multiple regression analysis in men: beta 0,095, F 5.47, P< 0.001 and women: beta 0,069, F 4.36, P<0.001. During follow-up 319 CV deaths occurred. Kaplan-Meier curves showed a significantly poorer survival rate in subjects with higher SUA (> 5.6 mg/dl in men and 5.1 mg/dl in women) and LVH (log-rank chi-square 298.105; P<0.0001). At multivariate Cox regression analysis in women LVH alone and the combination of higher SUA and LVH but not hyperuricemia alone, were associated with a higher risk of CV death, while in men hyperuricemia without LVH, LVH without hyperuricemia and their combination were all associated with a higher incidence of CV death. CONCLUSIONS Our findings demonstrate that SUA is independently associated with LVMI and suggest that the combination of hyperuricemia with LVH is an independent and powerful predictor for CV death both in men and women.

Published
2023

87. Synuclein α accumulation mediates podocyte injury in Fabry nephropathy

Author

Braun, Fabian, primary, Abed, Ahmed, additional, Sellung, Dominik, additional, Rogg, Manuel, additional, Woidy, Mathias, additional, Eikrem, Oysten, additional, Wanner, Nicola, additional, Gambardella, Jessica, additional, Laufer, Sandra D., additional, Haas, Fabian, additional, Wong, Milagros N., additional, Dumoulin, Bernhard, additional, Rischke, Paula, additional, Mühlig, Anne K., additional, Sachs, Wiebke, additional, von Cossel, Katharina, additional, Schulz, Kristina, additional, Muschol, Nicole, additional, Gersting, Sören W., additional, Muntau, Ania C., additional, Kretz, Oliver, additional, Hahn, Oliver, additional, Rinschen, Markus M., additional, Mauer, Michael, additional, Bork, Tillmann, additional, Grahammer, Florian, additional, Liang, Wei, additional, Eierhoff, Thorsten, additional, Römer, Winfried, additional, Hansen, Arne, additional, Meyer-Schwesinger, Catherine, additional, Iaccarino, Guido, additional, Tøndel, Camilla, additional, Marti, Hans-Peter, additional, Najafian, Behzad, additional, Puelles, Victor G., additional, Schell, Christoph, additional, and Huber, Tobias B., additional

Published
2023
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88. Serum uric acid and left ventricular mass index independently predict cardiovascular mortality: The uric acid right for heart health (URRAH) project

Author

Muiesan, Maria Lorenza, primary, Agabiti Rosei, Claudia, additional, Paini, Anna, additional, Casiglia, Edoardo, additional, Cirillo, Massimo, additional, Grassi, Guido, additional, Iaccarino, Guido, additional, Mallamaci, Francesca, additional, Maloberti, Alessandro, additional, Mazza, Alberto, additional, Mengozzi, Alessandro, additional, Palatini, Paolo, additional, Parati, Gianfranco, additional, Reboldi, Gianpaolo, additional, Rivasi, Giulia, additional, Russo, Elisa, additional, Salvetti, Massimo, additional, Tikhonoff, Valerie, additional, Tocci, Giuliano, additional, and Borghi, Claudio, additional

Published
2023
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93. Digital Health Service for Identification of Frailty Risk Factors in Community-Dwelling Older Adults: The SUNFRAIL+ Study Protocol

Author

De Luca, Vincenzo, primary, Femminella, Grazia Daniela, additional, Leonardini, Lisa, additional, Patumi, Lola, additional, Palummeri, Ernesto, additional, Roba, Isabella, additional, Aronni, Walter, additional, Toccoli, Stefano, additional, Sforzin, Simona, additional, Denisi, Fortunata, additional, Basso, Anna Maddalena, additional, Ruatta, Manuela, additional, Obbia, Paola, additional, Rizzo, Alessio, additional, Borgioli, Moira, additional, Eccher, Claudio, additional, Farina, Riccardo, additional, Conforti, Diego, additional, Mercurio, Lorenzo, additional, Salvatore, Elena, additional, Gentile, Maurizio, additional, Bocchino, Marialuisa, additional, Sanduzzi Zamparelli, Alessandro, additional, Viceconte, Giulio, additional, Gentile, Ivan, additional, Ruosi, Carlo, additional, Ferrara, Nicola, additional, Fabbrocini, Gabriella, additional, Colao, Annamaria, additional, Triassi, Maria, additional, Iaccarino, Guido, additional, Liotta, Giuseppe, additional, and Illario, Maddalena, additional

Published
2023
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94. Serum Uric Acid Predicts All-Cause and Cardiovascular Mortality Independently of Hypertriglyceridemia in Cardiometabolic Patients without Established CV Disease: A Sub-Analysis of the URic acid Right for heArt Health (URRAH) Study

Author

Mengozzi, Alessandro, primary, Pugliese, Nicola Riccardo, additional, Desideri, Giovambattista, additional, Masi, Stefano, additional, Angeli, Fabio, additional, Barbagallo, Carlo Maria, additional, Bombelli, Michele, additional, Cappelli, Federica, additional, Casiglia, Edoardo, additional, Cianci, Rosario, additional, Ciccarelli, Michele, additional, Cicero, Arrigo F. G., additional, Cirillo, Massimo, additional, Cirillo, Pietro, additional, Dell’Oro, Raffaella, additional, D’Elia, Lanfranco, additional, Ferri, Claudio, additional, Galletti, Ferruccio, additional, Gesualdo, Loreto, additional, Giannattasio, Cristina, additional, Grassi, Guido, additional, Iaccarino, Guido, additional, Lippa, Luciano, additional, Mallamaci, Francesca, additional, Maloberti, Alessandro, additional, Masulli, Maria, additional, Mazza, Alberto, additional, Muiesan, Maria Lorenza, additional, Nazzaro, Pietro, additional, Palatini, Paolo, additional, Parati, Gianfranco, additional, Pontremoli, Roberto, additional, Quarti-Trevano, Fosca, additional, Rattazzi, Marcello, additional, Reboldi, Gianpaolo, additional, Rivasi, Giulia, additional, Russo, Elisa, additional, Salvetti, Massimo, additional, Tikhonoff, Valerie, additional, Tocci, Giuliano, additional, Ungar, Andrea, additional, Verdecchia, Paolo, additional, Viazzi, Francesca, additional, Volpe, Massimo, additional, Borghi, Claudio, additional, and Virdis, Agostino, additional

Published
2023
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95. 596 TARGETING GRK2 TO PREVENT AORTIC VALVE CALCIFICATION

Author

Rusciano, Maria Rosaria, primary, Sorriento, Daniela, additional, Valerio, Vincenza, additional, Toni, Anna Laura, additional, Di Pietro, Paola, additional, Carrizzo, Albino, additional, Iaccarino, Guido, additional, Poggio, Paolo, additional, Vecchione, Carmine, additional, and Ciccarelli, Michele, additional

Published
2022
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98. Erratum: Gender differences in predictors of intensive care units admission among COVID-19 patients: The results of the SARSRAS study of the Italian Society of Hypertension (PLoS ONE (2020) 15:10 (e0237297) DOI: 10.1371/journal.pone.0237297)

Author

Iaccarino, Guido, Iaccarino, G, Grassi, G, Borghi, C, Carugo, S, Fallo, F, Ferri, C, Giannattasio, C, Grassi, D, Letizia, C, Mancusi, C, Minuz, P, Perlini, S, Pucci, G, Rizzoni, D, Salvetti, M, Sarzani, R, Sechi, L, Veglio, F, Volpe, M, Muiesan, M, Iaccarino, Guido, Grassi, Guido, Borghi, Claudio, Carugo, Stefano, Fallo, Francesco, Ferri, Claudio, Giannattasio, Cristina, Grassi, Davide, Letizia, Claudio, Mancusi, Costantino, Minuz, Pietro, Perlini, Stefano, Pucci, Giacomo, Rizzoni, Damiano, Salvetti, Massimo, Sarzani, Riccardo, Sechi, Leonardo, Veglio, Franco, Volpe, Massimo, Muiesan, Maria Lorenza, Iaccarino, Guido, Iaccarino, G, Grassi, G, Borghi, C, Carugo, S, Fallo, F, Ferri, C, Giannattasio, C, Grassi, D, Letizia, C, Mancusi, C, Minuz, P, Perlini, S, Pucci, G, Rizzoni, D, Salvetti, M, Sarzani, R, Sechi, L, Veglio, F, Volpe, M, Muiesan, M, Iaccarino, Guido, Grassi, Guido, Borghi, Claudio, Carugo, Stefano, Fallo, Francesco, Ferri, Claudio, Giannattasio, Cristina, Grassi, Davide, Letizia, Claudio, Mancusi, Costantino, Minuz, Pietro, Perlini, Stefano, Pucci, Giacomo, Rizzoni, Damiano, Salvetti, Massimo, Sarzani, Riccardo, Sechi, Leonardo, Veglio, Franco, Volpe, Massimo, and Muiesan, Maria Lorenza

Published
2021

99. Assessment Tools of Biopsychosocial Frailty Dimensions in Community-Dwelling Older Adults: A Narrative Review

Author

De Luca, Vincenzo, primary, Femminella, Grazia Daniela, additional, Patalano, Roberta, additional, Formosa, Valeria, additional, Lorusso, Grazia, additional, Rivetta, Cristiano, additional, Di Lullo, Federica, additional, Mercurio, Lorenzo, additional, Rea, Teresa, additional, Salvatore, Elena, additional, Korkmaz Yaylagul, Nilufer, additional, Apostolo, Joao, additional, Silva, Rosa Carla, additional, Dantas, Carina, additional, van Staalduinen, Willeke H., additional, Liotta, Giuseppe, additional, Iaccarino, Guido, additional, Triassi, Maria, additional, and Illario, Maddalena, additional

Published
2022
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100. Serum uric acid / serum creatinine ratio as a predictor of cardiovascular events. Detection of prognostic cardiovascular cut-off values

Author

Casiglia, Edoardo, primary, Tikhonoff, Valérie, additional, Virdis, Agostino, additional, Grassi, Guido, additional, Angeli, Fabio, additional, Barbagallo, Carlo M., additional, Bombelli, Michele, additional, Cicero, Arrigo F.G., additional, Cirillo, Massimo, additional, Cirillo, Pietro, additional, Dell’Oro, Raffaella, additional, D’elia, Lanfranco, additional, Desideri, Giovambattista, additional, Ferri, Claudio, additional, Galletti, Ferruccio, additional, Gesualdo, Loreto, additional, Giannattasio, Cristina, additional, Iaccarino, Guido, additional, Lippa, Luciano, additional, Mallamaci, Francesca, additional, Masi, Stefano, additional, Maloberti, Alessandro, additional, Masulli, Maria, additional, Mazza, Alberto, additional, Mengozzi, Alessandro, additional, Muiesan, Maria Lorenza, additional, Nazzaro, Pietro, additional, Palatini, Paolo, additional, Parati, Gianfranco, additional, Pontremoli, Roberto, additional, Quarti-Trevano, Fosca, additional, Rattazzi, Marcello, additional, Reboldi, Gianpaolo, additional, Rivasi, Giulia, additional, Salvetti, Massimo, additional, Tocci, Giuliano, additional, Ungar, Andrea, additional, Verdecchia, Paolo, additional, Viazzi, Francesca, additional, Volpe, Massimo, additional, and Borghi, Claudio, additional

Published
2022
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