51. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part I): classification of paper patients by expert opinion including uncertainty appraisal
- Author
-
M A Khan, Ben A. C. Dijkmans, Maxime Dougados, J Brandt, I. Olivieri, K. de Vlam, Marjatta Leirisalo-Repo, Herman Mielants, Jürgen Braun, Eduardo Collantes-Estevez, Joachim Listing, Walter P. Maksymowych, Martin Rudwaleit, John A. Davis, Paul Emery, S van der Linden, Rubén Burgos-Vargas, Robert D. Inman, I E van der Horst-Bruinsma, Robert Landewé, D. van der Heijde, Roger D. Sturrock, Joachim Sieper, Rheumatology, CCA - Disease profiling, Chemistry and Biology, and Other departments
- Subjects
030203 arthritis & rheumatology ,Ankylosing spondylitis ,medicine.medical_specialty ,business.industry ,Inflammatory back pain ,Radiography ,Immunology ,Sacroiliitis ,Odds ratio ,medicine.disease ,General Biochemistry, Genetics and Molecular Biology ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Expert opinion ,medicine ,Physical therapy ,Immunology and Allergy ,030212 general & internal medicine ,Axial spondyloarthritis ,Stage (cooking) ,business - Abstract
Objective: Non-radiographic axial spondyloarthritis (SpA) is characterised by a lack of definitive radiographic sacroiliitis and is considered an early stage of ankylosing spondylitis. The objective of this study was to develop candidate classification criteria for axial SpA that include patients with but also without radiographic sacroiliitis. Methods: Seventy-one patients with possible axial SpA, most of whom were lacking definite radiographic sacroiliitis, were reviewed as "paper patients" by 20 experts from the Assessment of SpondyloArthritis international Society (ASAS). Unequivocally classifiable patients were identified based on the aggregate expert opinion in conjunction with the expert-reported level of certainty of their judgement. Draft criteria for axial SpA were formulated and tested using classifiable patients. Results: Active sacroiliitis on magnetic resonance imaging (MRI) (odds ratio 45, 95% CI 5.3 to 383; p
- Published
- 2009