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A reaction between 4,4′,4″-(benzene-1,3,5-triyltris(oxy))triphthalic acid (H6L) and lanthanide(III) nitrates (Ln = Eu3+, Tb3+) in water under the same conditions gave a molecular coordination compound [Tb(H4.5L)2(H2O)5]∙6H2O in the case of terbium(III) and a one-dimensional linear coordination polymer {[Eu2(H3L)2(H2O)6]∙8H2O}n in the case of europium(III). The crystal structures of both compounds were established by single-crystal X-ray diffraction, and they were further characterized by powder X-ray diffraction, thermogravimetric analysis and infrared spectroscopy. The compounds demonstrated characteristic lanthanide-centered photoluminescence. The lanthanide-dependent dimensionality of the synthesized compounds, which are the first examples of the coordination compounds of hexacarboxylic acid H6L demonstrates its potential as a linker for new coordination polymers.

Two half-sandwich iridium(III) and rhodium(III) complexes with 11H-indeno[1,2-b]quinoxalin-11-one oxime (IQ-1) ligand were prepared by the reaction of the proligand with [M(Cp*)Cl2]2 (M = Ir, Rh) dimers. The reaction between IQ-1 and [Ir(Cp*)Cl2]2 in methanol gave the complex [Ir(Cp*)(IQ-1)Cl] (1), which crystallized in a centrosymmetric space group as a true racemate. Whereas complex [Rh(Cp*)(IQ-1)Cl] (2) in the form of a racemic conglomerate was obtained by the reaction of [Rh(Cp*)Cl2]2 and IQ-1 in methanol. The crystal structures of complexes 1 and 2 (R and S enantiomers) were determined by X-ray diffraction analysis, and the structural features were compared in order to understand the structural factors leading to the spontaneous enantiomer resolution of the rhodium(III) complex. In the crystal packing of 1, intermolecular C–H···C contacts between a pair of enantiomers link the molecules into centrosymmetric dimers and lead to the formation of heterochiral crystals of 1. In contrast, the intramolecular contacts CH···Cl and CH···C in complex 2 bind all three ligands around the chiral Rh(III) metal center. In addition, a combination of intermolecular CH···O and CH···C contacts leads to the formation of a homochiral supramolecular structure. These interactions altogether reinforce the spontaneous resolution in complex 2.

Porokeratosis is a clonal disorder of the keratinization of the epidermis, manifested by atrophic papules or patches, surrounded by the hyperkeratotic ridge-like border, that corresponds to cornoid lamella histologically. We reported an association of a rare form of that distinctive disease – Porokeratosis Palmaris et plantaris disseminate with vitiligo in a 62-year-old female with rheumatoid arthritis on immunosuppressant treatment.

Relevance of the research. In the main pipelines for transportation as well as in tanks for oil and gas storage the heat-shielding coverings from various materials are applied. The heat-shielding of these objects is inevitably intensively affected by various climatic factors, and in certain cases by mechanical influence that leads to degradation of its properties. Development of intellectual information and measuring system with reconfigurable structure for operating control of heat-insulating materials condition, which allows expanding the functionality of the existing similar systems and providing the required accuracy of measurements, is important and relevant. The aim of the research is to increase the accuracy in determining the coefficient of heat conductivity of various heat-shielding coverings of the main pipelines and tanks by their production and operation for prevention of deterioration in properties of thermal insulation under the influence of the external influencing factors. Objects: heat-shielding coverings of the main pipelines and tanks used in oil and gas transporting and storage. Methods. The methodological basis at solution of objectives of design of intellectual information and measuring system of heatphysical properties of materials consists in: theory of measuring systems, artificial intelligence methods, Bayesian approach. Results. The authors have developed the conceptual model of designing the intellectual information and measuring system of heatphysical properties of heat-insulating coverings of the main pipelines for oil and gas transportation and tanks at storage. Within the conceptual model the authors developed the technique for defining a measuring situation in heatphysical measurements on the basis of preliminary identification of properties of the studied material using the Bayesian approach to processing the output signals of primary measuring converters and structural components of the measuring channel of system. The authors designed the model of reconfiguring and the relevant structure of intellectual information and measuring system of heatphysical properties of heat-insulating coverings to increase the accuracy of determination of coefficient of heat conductivity of heat-insulating materials. The relative error of measurement of coefficient of heat conductivity when using the offered system makes no more than 5 %.

The first case of heart transplantation in the Far Eastern Federal District described. Transplantation of heart is executed in Republican hospital No. 1 - the National center of medicine (Yakutsk) on July 6, 2018. In our opinion, transplantation of heart is necessary and feasible in such regions as the Republic of Sakha (Yakutia) which have difficult and extreme climate and geography, remote settlements with population less than 1 million people.

Objective. To analyze the protective effect of atorvastatin loading dose on the reduction of myocardial injury associated with percutaneous coronary intervention, left ventricular systolic functionand exercise tolerancein patients with endovascular recanalization of chronic atherosclerotic total occlusions. Methods. 82 patients underwent recanalization. The patients in the main group ( n = 38) received a loading dose of atorvastatin 80 mg before surgery. Patients in control group ( n = 44) received 20 mg of atorvastatin. In both groups Troponin I, CF fraction of creatine phosphokinaseweremeasured, echocardiographyand veloergometer test were performed prior to surgery, 24 hours, 1 month, 1 year after the surgery. Results. There was no difference in Troponin I and CF fraction of creatine phosphokinase initial levels. In 24 hours in the main group in 3 patients (7,9 %) there was discovered moderate troponin I rising. In the control group there were 11 (25 %) patients with increasing in troponin I level in 5 and more times. CF fraction of creatine phosphokinase in control group was increased in 3 (7,9 %) patients, in the control group this parameter was increased in 16 (36,4 %) patients. In 1 month and 1 year Troponin Iand CF fraction of creatine phosphokinaselevel was normal in the both groups.There were no statistically significant changes in echocardiography parametersor exercise tolerance during the all follow-up period. Conclusion. Atorvastatin loading dose has a protective effect and prevents periprocedural myocardial injury. At the same time it doesn’t influence on central hemodynamics parameters measured by echocardiography.

The article describes the issues of teaching programming in the school at computer science (Computing) lessons. The authors have analyzed how the school computer science (computing) course has changed in recent years. In addition, an analysis of modern approaches to teaching programming in Russia and Western countries has been carried out. Referring to the research of leading specialists, the authors of the article suggest using the technology of gamification in the teaching of programming in school. The authors analyze the foreign experience in teaching programming in the school and distinguish three main software products: Alice, GreenFoot and Scratch. Based on the discussion organized by Fincher S., as well as the work of Kolling M., Hirsch M. and Horton M, the authors choose to approbate the GreenFoot software shell, which is not common in Russia. An important part of the selection is that the software environment allows you to combine instruction in object-oriented programming using Java syntax and gaming technology. In addition, the authors suggest that the use of the GreenFoot software makes it easier to switch to object-oriented programming for children who have mastered the previously visually-oriented software environment Scratch. The article is not limited to theoretical research. The authors describe the experiment conducted at the school, designed to determine the permissibility and possibility of implementing GreeneFoot at the level of 5-6 grade of the general education school (pupils 10-12 years of age). One of the most important goals of this study was the definition of the "boundaries of entry" of schoolchildren in the course of mastering object-oriented programming using the GreeneFoot environment. In particular, the identification of the initial age and the requirements for pre-training. The article describes the results of the experiment, which was based on the localization and preparation of a test curriculum. In addition, the results of incoming and outgoing monitoring are described, revealing the level of initial training of participants, as well as their interest in programming. The authors presented and analyzed the results of the experiment, in particular, conclusions were made about the prospects for the technology of gaming and the applicability of the GreenFoot environment at the 6th grade level. In addition, the authors identified the ways of further research in the field of developing object-oriented programming by schoolchildren.

Cancer genomes harbor numerous genomic alterations and many cancers accumulate thousands of nucleotide sequence variations. A prominent fraction of these mutations arises as a consequence of the off-target activity of DNA/RNA editing cytosine deaminases followed by the replication/repair of edited sites by DNA polymerases (pol), as deduced from the analysis of the DNA sequence context of mutations in different tumor tissues. We have used the weight matrix (sequence profile) approach to analyze mutagenesis due to Activation Induced Deaminase (AID) and two error-prone DNA polymerases. Control experiments using shuffled weight matrices and somatic mutations in immunoglobulin genes confirmed the power of this method. Analysis of somatic mutations in various cancers suggested that AID and DNA polymerases η and θ contribute to mutagenesis in contexts that almost universally correlate with the context of mutations in A:T and G:C sites during the affinity maturation of immunoglobulin genes. Previously, we demonstrated that AID contributes to mutagenesis in (de)methylated genomic DNA in various cancers. Our current analysis of methylation data from malignant lymphomas suggests that driver genes are subject to different (de)methylation processes than non-driver genes and, in addition to AID, the activity of pols η and θ contributes to the establishment of methylation-dependent mutation profiles. This may reflect the functional importance of interplay between mutagenesis in cancer and (de)methylation processes in different groups of genes. The resulting changes in CpG methylation levels and chromatin modifications are likely to cause changes in the expression levels of driver genes that may affect cancer initiation and/or progression.

Recently, Ti-Ni based intermetallic alloys with shape memory effect (SME) have attracted much attention as promising functional materials for the development of record small nanomechanical tools, such as nanotweezers, for 3D manipulation of the real nano-objects. The problem of the fundamental restrictions on the minimal size of the nanomechanical device with SME for manipulation is connected with size effects which are observed in small samples of Ti-Ni based intermetallic alloys with thermoplastic structural phase transition from austenitic high symmetrical phase to low symmetrical martensitic phase. In the present work, by combining density functional theory and molecular dynamics modelling, austenite has been shown to be more stable than martensite in nanometer-sized TiNi wafers. In this case, the temperature of the martensitic transition asymptotically decreases with a decrease in the plate thickness h, and the complete suppression of the phase transition occurs for a plate with a thickness of 2 nm, which is in qualitative agreement with the experimental data. Moreover, the theoretical values obtained indicate the potential for even greater minimization of nanomechanical devices based on SME in TiNi.

This article studies problems of forecasting of noise pollution by thermal power plant equipment, industrial boilers, etc. An acoustic model of a residential area, exposed to power plant equipment noise nuisance, has been developed by means of AWM “Acoustics” software using obtained data. Practical application of the experimental-theoretical model for the noise field was demonstrated for efficiency estimation of the proposed engineering solution to noise reduction.

In the article, an analysis provided of recent views on the overtraining syndrome by the data from local and foreign publications.The witness of the problem actuality is also an existence of controversial opinions and absence of clear definitions on properties of the condition. It has been revealed that the main role in pathogenesis of the overtraining syndrome do play the changes of cardiovascular, endocrine and central nervous systems. These changes are complicated and ambiguous, depend upon multiple factors, as the type of sport, specifics of exertion and loads, stage of pathophysiological process. Entraining effect of exertion, if incorrectly utilized, underestimation of current condition of a sportsman, might not lead to expected results. Moreover, non-rational application of exertion might lead to opposite effect, that is, to decrease adaptation potential and reserves, towards the edge of the condition as an overtraining syndrome, which shows phasic, progressing character, starting from fatigue and mild disorders, to persistent, rigidly reversible processes.Due to controversy, multiple stages and multifactorial of the overtraining syndrome, by now there is no unified approach to its definition, as no unified standards to its diagnostics, treatment and prevention.

А calculation scheme for the utilization of chips of old wooden sleepers in a vortex furnace is proposed. The vortex furnace provides two zones of reaction of a combustible substance with air: the primary zone is the gasification of old sleepers and the afterburning of the solid residue with a lack of air oxygen, the secondary zone is the burning of the gas phase. The initial data for the thermodynamic calculation is given. The results of the equilibrium calculation of the thermal decomposition of wood on the grate and the combustion of gasification products are presented for different values of the excess air factor, as well as some experimental data. A comparison of the calculation results with the experimental data is carried out.

A total of 2,431 patients with diabetic foot syndrome (DFS) who underwent inpatient treatment in the purulent surgery units of 6 large hospitals in Chelyabinsk were examined. Most patients with DFS suffered from type 2 diabetes (87,8%). Most (69,4%) of patients with purulent necrotic complications of DFS were over 60 years old (55,1% among men and 76,4% among women). The complications were subdivided into predominantly ischemic (gangrene, critical ischemia), predominantly neuropathic (pressure ulcers, osteomyelitis) and predominantly suppurative (purulent wounds, abscesses, phlegmon) according to the nature and the underlying cause for the development of purulent necrotic processes observed in various forms of DFS. The diabetic patients with neuropathy of the feet had pressure ulcers and chronic osteomyelitis lesions of the foot (44,6%) more often than those with ischemia (5,7%, p

A luminescent coordination polymer with the overall formula {[Zn(tr2btd)(bpdc)]∙DMF}n (where tr2btd = 4,7-di(1H-1,2,4-triazol-1-yl)-2,1,3-benzothiadiazole; bpdc = 4,4′-biphenyldicarboxylate) was synthesized and characterized by single-crystal and powder X-ray diffraction, thermogravimetric, infrared spectroscopy, and elemental analyses. Luminescent properties of the obtained compound were studied in detail both in the solid state and as a suspension in N,N-dimethylacetamide (DMA). It was found that {[Zn(tr2btd)(bpdc)]∙DMF}n exhibits bright turquoise luminescence with excellent quantum efficiency and demonstrates turn-on fluorescence enhancement effect upon soaking in DMA Al3+ solution. Fluorescence titration experiments were carried out and the detection limit for Al3+ ions was calculated to be 120 nM, which is among the lowest reported values for similar materials. Moreover, compound demonstrated excellent selectivity and reusability, and the mechanism of the response is discussed. These results indicate that {[Zn(tr2btd)(bpdc)]∙DMF}n is a promising probe for sensitive fluorescent Al3+ detection.

Graphene derivatization to either engineer its physical and chemical properties or overcome the problem of the facile synthesis of nanographenes is a subject of significant attention in the nanomaterials research community. In this paper, we propose a facile and scalable method for the synthesis of thiolated graphene via a two-step liquid-phase treatment of graphene oxide (GO). Employing the core-level methods, the introduction of up to 5.1 at.% of thiols is indicated with the simultaneous rise of the C/O ratio to 16.8. The crumpling of the graphene layer upon thiolation without its perforation is pointed out by microscopic and Raman studies. The conductance of thiolated graphene is revealed to be driven by the Mott hopping mechanism with the sheet resistance values of 2.15 kΩ/sq and dependable on the environment. The preliminary results on the chemiresistive effect of these films upon exposure to ethanol vapors in the mix with dry and humid air are shown. Finally, the work function value and valence band structure of thiolated graphene are analyzed. Taken together, the developed method and findings of the morphology and physics of the thiolated graphene guide the further application of this derivative in energy storage, sensing devices, and smart materials.

For a scenario of a close flyby of a compact star near a spinning black hole, we provide analytical and numerical estimates for the shift of trajectory periastron due to relativistic (beyond post-Newtonian) effects. More specifically, we derived a generalized expression (not limited to quasi-circular or elliptical orbits) directly linking the periastron shift and the spin of the black hole. The expression permits the estimation of black hole spin based on astronomical tracking of locations of stars traveling along highly eccentric (parabolic and hyperbolic) trajectories in close vicinity of a black hole. We also demonstrate how stars traveling on hyperbolic or parabolic trajectories may be (temporarily) captured onto quasi-circular orbits around black holes, and we quantitatively examine conditions for such scenarios.

We study the dynamics of dust particles in a stratified glow discharge in inhomogeneous magnetic fields. Dust structures are formed in standing striations, in which traps for dust particles arise. When a magnetic field is applied, these structures begin to rotate. The observations were carried out in striations near the end of the solenoid, where the region of an inhomogeneous magnetic field begins. With an increase in the magnetic field, the dusty structure can be deformed. The rotation of a dusty structure in an inhomogeneous magnetic field has been studied in detail; it has its own peculiarities in comparison with rotation in a uniform field. We have considered the mechanisms of such rotation and estimated its velocity.

Although the high-fat-diet-induced metabolic syndrome (MetS) is a precursor of human cardiac pathology, the myocardial metabolic state in MetS is far from clear. The discrepancies in metabolite handling between human and small animal models and the difficulties inherent in obtaining human tissue complicate the identification of the myocardium-specific metabolic response in patients. Here we use the large animal model of swine that develops the hallmark criteria of human MetS. Our comparative metabolomics together with transcriptomics and computational nonnegative matrix factorization (NMF) interpretation of the data exposes significant decline in metabolites related to the fatty acid oxidation, glycolysis, and pentose phosphate pathway. Behind the reversal lies decreased expression of enzymes that operate in the pathways. We showed that diminished glycogen deposition is a metabolic signature of MetS in the pig myocardium. The depletion of glycogen arises from disbalance in expression of genes that break down and synthesize glycogen. We show robust acetoacetate accumulation and activated expression of key enzymes in ketone body formation, catabolism and transporters, suggesting a shift in fuel utilization in MetS. A contrasting enrichment in O-GlcNAcylated proteins uncovers hexosamine pathway and O-GlcNAcase (OGA) expression involvement in the myocardial response to MetS. Although the hexosamine biosynthetic pathway (HBP) activity and the availability of the UDP-GlcNAc substrate in the MetS myocardium is low, the level of O-GlcNacylated proteins is high as the O-GlcNacase is significantly diminished. Our data support the perception of transcriptionally driven myocardial alterations in expression of standard fatty acids, glucose metabolism, glycogen, and ketone body related enzymes and subsequent paucity of their metabolite products in MetS. This aberrant energy metabolism in the MetS myocardium provide insight into the pathogenesis of CVD in MetS.

Mono- and binuclear arene–ruthenium(II) complexes with imidazole-containing ligands were prepared by the reaction of the ligands (L1 = bis(imidazole-1-yl)methane; ImH = 1H-Imidazole; BImH = 1H-Benzimidazole) with [(p-cym)Ru(µ-Cl)2]2 dimers. When bis(imidazole-1-yl)methane reacted with [(p-cym)Ru(µ-Cl)2]2 in methanol, a binuclear complex of the type [Ru2(L1)2(p-cym)2Cl2]Cl2 (2) with cyclic structure was synthesized, whereas by using acetonitrile as a solvent under the same reaction conditions, an unexpected C–N bond cleavage was observed, and a complex of formula [Ru(ImH)2(p-cym)Cl]Cl (1) with coordinated imidazole molecules was obtained. Another type of arene–ruthenium complex [Ru(BImH)(p-cym)Cl2] (3) was obtained by the reaction of benzimidazole and [(p-cym)Ru(µ-Cl)2]2. All compounds were characterized by spectral (FT-IR, NMR 1H, 13C) and single-crystal X-ray diffraction methods; their catalytic activity in transfer hydrogenation and the cytotoxicity against MCF-7 and HepG2 cells were evaluated.

In expansion of our recent proposal that the solar system’s evolution occurred in two stages—during the first stage, the gaseous giants formed (via disk instability), and, during the second stage (caused by an encounter with a particular stellar-object leading to “in-system” fission-driven nucleogenesis), the terrestrial planets formed (via accretion)—we emphasize here that the mechanism of formation of such stellar-objects is generally universal and therefore encounters of such objects with stellar-systems may have occurred elsewhere across galaxies. If so, their aftereffects may perhaps be observed as puzzling features in the spectra of individual stars (such as idiosyncratic chemical enrichments) and/or in the structures of exoplanetary systems (such as unusually high planet densities or short orbital periods). This paper reviews and reinterprets astronomical data within the “fission-events framework”. Classification of stellar systems as “pristine” or “impacted” is offered.

The objective: to analyze the experience of use of cepeginterferonalfa-2b and ribavirin in patients with chronic hepatitis C genotypes 2 and 3 in clinical practice, to evaluate the efficacy, safety and tolerability of this treatment regimen.Materials and methods. From 2013 to 2016 a total of 73 patients with chronic hepatitis C (CHC) received antiviral therapy with cepeginterferon alfa 2b (cePEG-IFN alfa-2b) and ribavirin in the Center for Gastroenterology and Hepatology of FSBE «Vishnevsky Third Military Clinical Hospital» of Russian Ministry of Defence. Treatment efficacy was assessed by the rate of sustained virologic response (SVR) on 24 week after completion of antiviral therapy. All cases of deterioration of the patient’s condition and laboratory abnormalities were registered throughout the treatment period and follow up. Severity of adverse events was assessed in accordance with the classification of CTCAE (Common Terminology Criteria for Adverse Events).Results. 73 CHC patients genotype 2/3 received cePEGIFN alfa-2b 1.5 μg/kg/week and ribavirin 800-1400 mg/day based on body weight for 24 weeks. SVR 24 was registered in 94,7% (n=54) of patients with HCV genotype 3 and in 93,7% (n =15) patients with genotype 2. During the first 12 weeks of therapy the normalization of serum transaminase activities was registered. All adverse events were typical for interferon/ribavirin treatment regimen.Conclusion. According to our data the use of double treatment regimen (CePEG-IFN alfa-2b and ribavirin) is reasonable in patients who don’t have negative predictive factors of response to IFN-based therapy. The SVR rate in this group of patients was 94.5%.

The use of thermovision technology to diagnose failure of the combustion flame test tube of the main combustion chamber gas turbine engine is deal with in the article. Join the thermal radiation of the jet of combustion products and the internal elements was carried out using short-wave thermovision system AGA-782 with spectral spectral filters in several ranges from 3.2 to 5.6 microns. Thermovision is mounted on the axis of the flame tube. The output signal was recorded and processed on a computer in real time, allowing monitor the combustion process and the thermal state of the object during the experiment.

Background. Injuries are 3rd in the structure of the population mortality. Over the past 15 years, mortality from injury came on second place, ahead of cancer. Traumatic brain injury is the most common damage types and ranges from 36 to 40 % of all injuries. The incidence of posterior fossa hematomas among intracranial hematomas has been reported to be 2 to 3%. Objective. The aim of the present study was to investigate the features of posterior fossa hematoma, including posterior fossa epidural hematoma, posterior fossa subdural hematoma and intracerebellar hematoma. The aim of the study was to determine the clinical features and diagnosis of severe head injuries. Methods. Analyzed the medical records of patients admitted to the Department of Neurosurgery Regional Hospital. They can be: furrow branches of the middle meningeal artery; wedge-parietal sulcus sinus; Channels diploic veins; cleft wedge - occipital synchondrosis behind the backs of the pituitary fossa; occipital-mastoid suture. Results and conclusion. With the introduction of the practice of computer and magnetic resonance imaging to diagnose damage to structures in the presence of hematomas in the posterior fossa it became much easier. Since patients are not always in a conscious state data instrumental methods of diagnosis in a very short time allow the diagnosis and differential diagnosis in injuries that are accompanied by the presence of intracranial hematomas in the posterior fossa.

The paper describes a clinical case demonstrating the possibilities of using computed tomography (CT) in the diagnosis and treatment of botulinum toxin type A (BTA) treatment of mixed cervical dystonia (CD). The poor result of initial treatment is due to the fact that the abnormally active deep muscles of the neck were beyond the reach of injection. Routine clinical examination cannot identify a concurrence of the caput and collis types of CD in most cases, which occurred in our patient. Objective examination revealed displacement of the larynx to the left from the incisura thyroidea superior, which was characteristic of the left-sided rotational caput type of CD; however, CT detected mixed CD (a concurrence of torticollis and torticaput in the left). Cervical spine CT could visualize not only the superficial, but also deep dystonic muscles of the neck, specify a botulinum toxin therapy regimen, and estimate a difference in the volumes of the normal or dystonic inferior oblique muscle of the head with further intramuscular administration of botulinum toxin. The evaluation of the efficiency and safety of BTA therapy for this disease, as well as practical guidelines for the use of CT in the diagnosis and treatment of mixed CD are given.